Pub Date : 2022-05-01DOI: 10.23736/s2784-8477.21.01993-8
M. N. Cicero, Anna I. Memmo, I. Piccionello, Gabriele Seminara, A. Benfante, N. Scichilone
Patients with severe COVID-19 are characterized by local and systemic inflammatory responses, which are responsible for severe acute respiratory failure. Systemic corticosteroids have been used to counteract the inflammatory cascade in severe respiratory patients. The beneficial effect of corticosteroids may be counteracted by adverse effects, including delayed viral clearance and increased risk of secondary infection. In this regard, we describe a case of a 79-year-old man admitted to the Emergency Department of the Palermo Hospital (Italy) because of respiratory failure and pneumonia caused by SARS-CoV-2 infection who developed Nocardia otitidiscaviarum infection. This case highlights the need to consider coinfections in SARS-CoV-2 patients under high dose of steroids.
{"title":"A 79-year-old-man with SARS-CoV-2 pneumonia and unusual pulmonary co-infection","authors":"M. N. Cicero, Anna I. Memmo, I. Piccionello, Gabriele Seminara, A. Benfante, N. Scichilone","doi":"10.23736/s2784-8477.21.01993-8","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01993-8","url":null,"abstract":"Patients with severe COVID-19 are characterized by local and systemic inflammatory responses, which are responsible for severe acute respiratory failure. Systemic corticosteroids have been used to counteract the inflammatory cascade in severe respiratory patients. The beneficial effect of corticosteroids may be counteracted by adverse effects, including delayed viral clearance and increased risk of secondary infection. In this regard, we describe a case of a 79-year-old man admitted to the Emergency Department of the Palermo Hospital (Italy) because of respiratory failure and pneumonia caused by SARS-CoV-2 infection who developed Nocardia otitidiscaviarum infection. This case highlights the need to consider coinfections in SARS-CoV-2 patients under high dose of steroids.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"15 9","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72402616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.23736/s2784-8477.21.01957-4
S. Colella, R. Marra, E. Conte, G. Panella, F. Fioretti, C. Massaccesi, V. Parato, G. Petrelli, G. D’Amato, V. D’Emilio, A. Papi, U. Desai, M. Tamburrini
BACKGROUND: The final diagnosis of COVID-19 pneumonia relies on a clinical and radiological picture, along with SARS-CoV2 RNAdetection in the oral and nasal-pharyngeal swab. The latter, has a high rate of false negative results, even in presence of symptoms and radiological abnormalities suggestive for COVID-19. In case of an atypical or indeterminate radiological pattern, the need of excluding COVID-19 and ruling out other differential diagnoses would be necessary. In such settings, the role of invasive procedures for obtaining samples from the lower respiratory tract such flexible bronchoscopy has been debated, due to the risk of contagion. The aim of this study was to evaluate the role of flexible bronchoscopy with bronchial washing during the pandemic of COVID-19. We aimed to define the value of bronchial washing in patients with an atypical or indeterminate chest CT-scan pattern for viral pneumonia. METHODS: We retrospectively reviewed patients with an atypical or indeterminate CTscan pattern for COVID-19 pneumonia and a negative test for SARS-CoV2 RNAon oral/ nasal-pharyngeal swabs, who underwent bronchoscopy for bronchial washings to exclude or confirm the diagnosis of SARS-CoV2 pneumonia. RESULTS: Among the 44 patients included with an atypical or indeterminate chest CT-scan pattern for COVID-19 pneumonia, no SARS-CoV2 RNAwas detected in the bronchial washing. CONCLUSIONS: The role of bronchoscopy in the diagnosis of COVID-19 pneumonia is negligible in indeterminate or atypical patterns on chest CT scan. However, we should not shy away from these invasive procedures in these profiles of cases to exclude bronchoscopically diagnosed differential diagnoses like other infections and non-infectious causes.
{"title":"Bronchoscopy in suspected severe acute respiratory syndrome-Coronavirus 2 pneumonia with atypical and indeterminate computed tomography presentation: indispensable or dispensable?","authors":"S. Colella, R. Marra, E. Conte, G. Panella, F. Fioretti, C. Massaccesi, V. Parato, G. Petrelli, G. D’Amato, V. D’Emilio, A. Papi, U. Desai, M. Tamburrini","doi":"10.23736/s2784-8477.21.01957-4","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01957-4","url":null,"abstract":"BACKGROUND: The final diagnosis of COVID-19 pneumonia relies on a clinical and radiological picture, along with SARS-CoV2 RNAdetection in the oral and nasal-pharyngeal swab. The latter, has a high rate of false negative results, even in presence of symptoms and radiological abnormalities suggestive for COVID-19. In case of an atypical or indeterminate radiological pattern, the need of excluding COVID-19 and ruling out other differential diagnoses would be necessary. In such settings, the role of invasive procedures for obtaining samples from the lower respiratory tract such flexible bronchoscopy has been debated, due to the risk of contagion. The aim of this study was to evaluate the role of flexible bronchoscopy with bronchial washing during the pandemic of COVID-19. We aimed to define the value of bronchial washing in patients with an atypical or indeterminate chest CT-scan pattern for viral pneumonia. METHODS: We retrospectively reviewed patients with an atypical or indeterminate CTscan pattern for COVID-19 pneumonia and a negative test for SARS-CoV2 RNAon oral/ nasal-pharyngeal swabs, who underwent bronchoscopy for bronchial washings to exclude or confirm the diagnosis of SARS-CoV2 pneumonia. RESULTS: Among the 44 patients included with an atypical or indeterminate chest CT-scan pattern for COVID-19 pneumonia, no SARS-CoV2 RNAwas detected in the bronchial washing. CONCLUSIONS: The role of bronchoscopy in the diagnosis of COVID-19 pneumonia is negligible in indeterminate or atypical patterns on chest CT scan. However, we should not shy away from these invasive procedures in these profiles of cases to exclude bronchoscopically diagnosed differential diagnoses like other infections and non-infectious causes.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85911826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.23736/s2784-8477.22.02000-9
A. Gerli, S. Centanni, J. Soriano, J. Ancochea
{"title":"Forecasting COVID-19 infection trends and hospitalizations in Italy due to SARS-CoV-2 variant of concern Omicron","authors":"A. Gerli, S. Centanni, J. Soriano, J. Ancochea","doi":"10.23736/s2784-8477.22.02000-9","DOIUrl":"https://doi.org/10.23736/s2784-8477.22.02000-9","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"18 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74504553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.23736/s2784-8477.21.01937-4
S. Low, M. Luu, Le Huu Nhat Minh, A. Abdelaal, Sze JIA NG, A. Gad, L. H. Nhi, T. Le, N. Huy
INTRODUCTION: This study aimed to systematically review the evidence reporting the key imaging findings in confirmed COVID-19 pneumonia. EVIDENCE ACQUISITION: A systematic search for articles reporting the prevalence of imaging findings in patients with COVID-19 pneumonia was conducted in seven databases up to April 10, 2020. The study protocol was registered in PROSPERO (CRD42020172528). EVIDENCE SYNTHESIS: A total of 25 imaging features were identified in 29 studies. The most characteristic radiographic features of COVID-19 pneumonia include peripheral distribution (92.4%, 95% CI: 86.8-95.8), bilateral involvement (82.8%, 95% CI: 76.0-87.9), and ground-glass opacities (GGO) (76.0%, 95% CI: 59.5-87.3). Right lower lobe (RLL) was the most frequently involved lobe (89.0%, 95% CI: 79.6-94.4), followed by left lower lobe (LLL) in 86.5% (95% CI: 74.8-93.2) of patients. The atypical imaging features included bronchial wall thickening, lymphadenopathy, and pleural effusion, which were observed more commonly in severe and critical COVID-19 pneumonia compared to mild and moderate condition. CONCLUSIONS: Chest imaging can help to diagnose COVID-19 pneumonia, especially in regions where the availability of RT -PCR testing kits is limited. Recognition of key radiographic features of COVID-19 pneumonia is essential to identify patients at early stages, monitor disease progression, and optimize their management plan.
{"title":"Chest imaging features of Coronavirus disease 2019 pneumonia: a systematic review and meta-analysis","authors":"S. Low, M. Luu, Le Huu Nhat Minh, A. Abdelaal, Sze JIA NG, A. Gad, L. H. Nhi, T. Le, N. Huy","doi":"10.23736/s2784-8477.21.01937-4","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01937-4","url":null,"abstract":"INTRODUCTION: This study aimed to systematically review the evidence reporting the key imaging findings in confirmed COVID-19 pneumonia. EVIDENCE ACQUISITION: A systematic search for articles reporting the prevalence of imaging findings in patients with COVID-19 pneumonia was conducted in seven databases up to April 10, 2020. The study protocol was registered in PROSPERO (CRD42020172528). EVIDENCE SYNTHESIS: A total of 25 imaging features were identified in 29 studies. The most characteristic radiographic features of COVID-19 pneumonia include peripheral distribution (92.4%, 95% CI: 86.8-95.8), bilateral involvement (82.8%, 95% CI: 76.0-87.9), and ground-glass opacities (GGO) (76.0%, 95% CI: 59.5-87.3). Right lower lobe (RLL) was the most frequently involved lobe (89.0%, 95% CI: 79.6-94.4), followed by left lower lobe (LLL) in 86.5% (95% CI: 74.8-93.2) of patients. The atypical imaging features included bronchial wall thickening, lymphadenopathy, and pleural effusion, which were observed more commonly in severe and critical COVID-19 pneumonia compared to mild and moderate condition. CONCLUSIONS: Chest imaging can help to diagnose COVID-19 pneumonia, especially in regions where the availability of RT -PCR testing kits is limited. Recognition of key radiographic features of COVID-19 pneumonia is essential to identify patients at early stages, monitor disease progression, and optimize their management plan.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"148 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75512164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.23736/s2784-8477.21.01984-7
G. Gessoni, L. Moro, Michela Pivetta, Accurso Aloi, A. Pasqual, Lorella Altafini, M. Orfano, F. Toffoletto, G. Roveroni, Alessia Bagatin, Raffaella Berti
{"title":"Role of convalescent plasma in severe COVID-19 patients: a single-center experience in Italy during the second epidemic wave","authors":"G. Gessoni, L. Moro, Michela Pivetta, Accurso Aloi, A. Pasqual, Lorella Altafini, M. Orfano, F. Toffoletto, G. Roveroni, Alessia Bagatin, Raffaella Berti","doi":"10.23736/s2784-8477.21.01984-7","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01984-7","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"133 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87036878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.23736/s2784-8477.21.01947-1
M. Ambrogi, E. Sicolo, O. Fanucchi, Alessandro Picchi, A. Ribechini
{"title":"A case of sequential endoscopic-surgical lung volume reduction: a bridge to lung transplantation","authors":"M. Ambrogi, E. Sicolo, O. Fanucchi, Alessandro Picchi, A. Ribechini","doi":"10.23736/s2784-8477.21.01947-1","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01947-1","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83331276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.23736/s2784-8477.21.01958-6
N. Sharma, R. Shukla, Kunal Kumar, Rachana Warrier, S. Arora, Vivek Kumar, Nalin Singh, Deepu K. Peter
Pneumomediastinum and pulmonary embolism are known complications of the COVID-19 disease. Our patient developed spontaneous pneumomediastinum twice during hospital admission along with acute pulmonary embolism. We managed this patient conservatively sticking to the basics of critical care and had a successful outcome. In our extensive literature search, we could not find any other case in which a patient with COVID-19 not on mechanical ventilation developed spontaneous pneumomediastinum twice during the hospital admission which was successfully managed conservatively.
{"title":"COVID-19 pneumonia and double whammy: let us stick to the basics","authors":"N. Sharma, R. Shukla, Kunal Kumar, Rachana Warrier, S. Arora, Vivek Kumar, Nalin Singh, Deepu K. Peter","doi":"10.23736/s2784-8477.21.01958-6","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01958-6","url":null,"abstract":"Pneumomediastinum and pulmonary embolism are known complications of the COVID-19 disease. Our patient developed spontaneous pneumomediastinum twice during hospital admission along with acute pulmonary embolism. We managed this patient conservatively sticking to the basics of critical care and had a successful outcome. In our extensive literature search, we could not find any other case in which a patient with COVID-19 not on mechanical ventilation developed spontaneous pneumomediastinum twice during the hospital admission which was successfully managed conservatively.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"11 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89471616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.23736/s2784-8477.21.01934-3
C. Guarino, Cristiano Cesaro, R. Lucci, S. Massa, E. Zamparelli, B. Polverino, G. Signoriello, Giuseppe La Cerra
{"title":"The role of elastography in course of endobronchial ultrasound in the determination of lymph node rigidity: a retrospective study","authors":"C. Guarino, Cristiano Cesaro, R. Lucci, S. Massa, E. Zamparelli, B. Polverino, G. Signoriello, Giuseppe La Cerra","doi":"10.23736/s2784-8477.21.01934-3","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01934-3","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"66 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74293259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：