Smily Jesu Priya Victor Paulra, Supaporn Chinchai, Peeraya Munkhetvit, Sarinya Sriphetcharawut
Background: Facial expression, tone of voice, body language, and context are unrecognizable to children with autism. Emotional arousal and emotion recognition (required emotion empathy and cognitive processing empathy) induce downstream illnesses in children with ASD. Thus, the proposed study aimed to develop a computer-based Emotional Recognition Memory Training Program (ERMTP) for ASD. Objective: Firstly, to develop and validate the ERMTP for social cognitive abilities in children with ASD and secondly, to conduct pilot-tested it in typically developing children and children with ASD. Materials and methods: This study consisted of 3 phases. The first phase was developing the ERMTP from the literature review. The second phase was analyzed for content validity with five experts about Task 1 (two activities) and Task 2 (nine activities) comprising ERMTP. Computer-based learning of six fundamental facial emotions (happy, sad, angry, fear, disgusted, and surprised) improves social cognition. Finally, the pilot test was analyzed to discover the ERMTP’s challenges for five children with typical development and ASD. Results: The ERMTP’s activity items have good content validity, especially regarding clarity and relevance. All five raters gave the intervention a 1.0 IOC for its distinct components. In the training program, we followed the expert instructions regarding background music or voice and the generalization task. Descriptive analysis indicated that all five normal-developing children followed emotional expressions and instructions (100%). All five parents reported there were changes in focus and memory skills. Emotion regulation, memory abilities, and the social cognition index demonstrated statistically significant (p<0.05) effects before and after ERMTP treatment in ASD. Conclusion: ERMTP seeks to improve the social cognition of children with ASD by the use of feedback from both specialists and the children themselves. However, further research will be necessary to investigate ASD using a randomized control trial.
{"title":"The development and content validity of the emotional recognition memory training program (ERMTP) for children with autism spectrum disorder: A trial phase","authors":"Smily Jesu Priya Victor Paulra, Supaporn Chinchai, Peeraya Munkhetvit, Sarinya Sriphetcharawut","doi":"10.12982/jams.2024.020","DOIUrl":"https://doi.org/10.12982/jams.2024.020","url":null,"abstract":"Background: Facial expression, tone of voice, body language, and context are unrecognizable to children with autism. Emotional arousal and emotion recognition (required emotion empathy and cognitive processing empathy) induce downstream illnesses in children with ASD. Thus, the proposed study aimed to develop a computer-based Emotional Recognition Memory Training Program (ERMTP) for ASD. Objective: Firstly, to develop and validate the ERMTP for social cognitive abilities in children with ASD and secondly, to conduct pilot-tested it in typically developing children and children with ASD. Materials and methods: This study consisted of 3 phases. The first phase was developing the ERMTP from the literature review. The second phase was analyzed for content validity with five experts about Task 1 (two activities) and Task 2 (nine activities) comprising ERMTP. Computer-based learning of six fundamental facial emotions (happy, sad, angry, fear, disgusted, and surprised) improves social cognition. Finally, the pilot test was analyzed to discover the ERMTP’s challenges for five children with typical development and ASD. Results: The ERMTP’s activity items have good content validity, especially regarding clarity and relevance. All five raters gave the intervention a 1.0 IOC for its distinct components. In the training program, we followed the expert instructions regarding background music or voice and the generalization task. Descriptive analysis indicated that all five normal-developing children followed emotional expressions and instructions (100%). All five parents reported there were changes in focus and memory skills. Emotion regulation, memory abilities, and the social cognition index demonstrated statistically significant (p<0.05) effects before and after ERMTP treatment in ASD. Conclusion: ERMTP seeks to improve the social cognition of children with ASD by the use of feedback from both specialists and the children themselves. However, further research will be necessary to investigate ASD using a randomized control trial.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"50 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139112764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jitapa Chawawisuttikool, Chatchai Phirawatthakul, Warintun Thomchaita, Chatchai Tieachanpan, O. Prasartwuth
Background: To prevent running related injuries and return to sport activities, monitoring the running dynamic parameters (cadence, stride length, ground contact time and vertical oscillation) especially outdoor running is crucial. Previous studies investigated the reliability of these parameters in laboratory settings. However, the nature of outdoor runs is different (curve, uphill, other runners, etc.) and challenging in terms of equipment (simple) and environments (grass, asphalt, rubber, etc.). Therefore, the reliability of these parameters using a fitness watch synced with accelerometer needed to be investigated. Objective: To investigate the reliability of running parameters measured using fitness watches and accelerometers during outdoor runs. Materials and methods: 30 healthy volunteers (age 25.8±9.6 years, height 167.2±9.3 cm, weight 62.4±14.2 kg, and body mass index 22.2±3.8 kg/m2) participated in the study. They wore a fitness watch and attached a synced accelerometer at their pants. They completed 2 running laps (800 meters each) at their comfortable speeds. Resting periods were provided between laps. To control the speed for the second lap, the watch was set the maximum and minimum speed and set vibration and sound alarm mode. Running parameters include cadence, stride length, vertical oscillation, and ground contact time. Results: The reliability of the four running parameters (cadence, stride length, ground contact time, and vertical oscillation), indicated by the intraclass correlation coefficients (ICC (3,k)) was 0.94, 0.97, 0.98 and 0.99, respectively. Very high reliability values were confirmed. Conclusion: Using a fitness watch synced with an accelerometer during outdoor runs, running dynamic parameters (cadence, stride length, ground contact time, and vertical oscillation) illustrated very high levels of reliability.
{"title":"Reliability of running parameters using fitness watches synced with accelerometers during outdoor runs","authors":"Jitapa Chawawisuttikool, Chatchai Phirawatthakul, Warintun Thomchaita, Chatchai Tieachanpan, O. Prasartwuth","doi":"10.12982/jams.2024.019","DOIUrl":"https://doi.org/10.12982/jams.2024.019","url":null,"abstract":"Background: To prevent running related injuries and return to sport activities, monitoring the running dynamic parameters (cadence, stride length, ground contact time and vertical oscillation) especially outdoor running is crucial. Previous studies investigated the reliability of these parameters in laboratory settings. However, the nature of outdoor runs is different (curve, uphill, other runners, etc.) and challenging in terms of equipment (simple) and environments (grass, asphalt, rubber, etc.). Therefore, the reliability of these parameters using a fitness watch synced with accelerometer needed to be investigated. Objective: To investigate the reliability of running parameters measured using fitness watches and accelerometers during outdoor runs. Materials and methods: 30 healthy volunteers (age 25.8±9.6 years, height 167.2±9.3 cm, weight 62.4±14.2 kg, and body mass index 22.2±3.8 kg/m2) participated in the study. They wore a fitness watch and attached a synced accelerometer at their pants. They completed 2 running laps (800 meters each) at their comfortable speeds. Resting periods were provided between laps. To control the speed for the second lap, the watch was set the maximum and minimum speed and set vibration and sound alarm mode. Running parameters include cadence, stride length, vertical oscillation, and ground contact time. Results: The reliability of the four running parameters (cadence, stride length, ground contact time, and vertical oscillation), indicated by the intraclass correlation coefficients (ICC (3,k)) was 0.94, 0.97, 0.98 and 0.99, respectively. Very high reliability values were confirmed. Conclusion: Using a fitness watch synced with an accelerometer during outdoor runs, running dynamic parameters (cadence, stride length, ground contact time, and vertical oscillation) illustrated very high levels of reliability.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"51 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139112807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Tatu, Wachirawit Tondee, Pornchai Khamtong, Lamplimas Tangphan, Jidapa Jaitiang
Background: Four university students of northern Thai descent were found to be HbE/βO-thalassemia. However, they all had a mild form of this disease, categorized as Non-Transfusion Dependent Thalassemia. Objectives: To analyze involvement of types of β-globin mutations, α-thalassemia, and XmnI-Gγ site in mild clinical symptoms observed in four Thai non-transfusion dependent HbE/βO-thalassemia cases. Materials and methods: EDTA blood samples were collected from the patients and their family members after signing the informed consent. Automated complete blood count with blood smear examination, hemoglobin typing, molecular analysis for α and β-globin mutations, β-globin gene haplotypes, and XmnI-Gγ site were performed on all blood samples. In addition, nucleotide sequencing of β-globin gene and globin chain separation were performed for patient#3 and their parents. Results: The first three patients had hemoglobin levels ranging 8.5-11.2 g/dL, while the fourth patient had hemoglobin level of 6.7 g/dL. The first and fourth patients were compound heterozygote for βE (HBB:c.79G>A) and β17 (HBB:c.52A>T) alleles with typical hemoglobin pattern of EF. The second patient was compound heterozygote for βE and β41/42 (HBB:c.126_129delCTTT) alleles also with typical hemoglobin pattern of EF. The third patient was compound heterozygote of βE and βIVS1-1(HBB:c.92+1G>T), however, with atypical hemoglobin pattern of EE. Family analysis found co-inheritance of Hb Constant Spring (HBA2:c.427T>C) and the XmnI-Gγ site (T at rs7482144) in the first two patients, of SEA-αO thalassemia (NG_000006.1:g.26264_45564del19301) and XmnI-Gγ site in the third patient, and of only XmnI-Gγ site in the fourth patient. Conclusion: These family studies proved the fact that co-existence of SEA-αO thalassemia and Hb Constant Spring in HbE/βO-thalassemia could lead to mild clinical severity. Minimal effect of XmnI-Gγ site on clinical symptoms of this disease was emphasized. This information should be useful in prenatal diagnosis of HbE/β-thalassemia.
{"title":"Non-transfusion dependent HbE/βO-thalassemia as the results of co-existent SEA-αO thalassemia, Hb Constant Spring, and XmnI-Gγ site: Thai family studies","authors":"T. Tatu, Wachirawit Tondee, Pornchai Khamtong, Lamplimas Tangphan, Jidapa Jaitiang","doi":"10.12982/jams.2024.006","DOIUrl":"https://doi.org/10.12982/jams.2024.006","url":null,"abstract":"Background: Four university students of northern Thai descent were found to be HbE/βO-thalassemia. However, they all had a mild form of this disease, categorized as Non-Transfusion Dependent Thalassemia. Objectives: To analyze involvement of types of β-globin mutations, α-thalassemia, and XmnI-Gγ site in mild clinical symptoms observed in four Thai non-transfusion dependent HbE/βO-thalassemia cases. Materials and methods: EDTA blood samples were collected from the patients and their family members after signing the informed consent. Automated complete blood count with blood smear examination, hemoglobin typing, molecular analysis for α and β-globin mutations, β-globin gene haplotypes, and XmnI-Gγ site were performed on all blood samples. In addition, nucleotide sequencing of β-globin gene and globin chain separation were performed for patient#3 and their parents. Results: The first three patients had hemoglobin levels ranging 8.5-11.2 g/dL, while the fourth patient had hemoglobin level of 6.7 g/dL. The first and fourth patients were compound heterozygote for βE (HBB:c.79G>A) and β17 (HBB:c.52A>T) alleles with typical hemoglobin pattern of EF. The second patient was compound heterozygote for βE and β41/42 (HBB:c.126_129delCTTT) alleles also with typical hemoglobin pattern of EF. The third patient was compound heterozygote of βE and βIVS1-1(HBB:c.92+1G>T), however, with atypical hemoglobin pattern of EE. Family analysis found co-inheritance of Hb Constant Spring (HBA2:c.427T>C) and the XmnI-Gγ site (T at rs7482144) in the first two patients, of SEA-αO thalassemia (NG_000006.1:g.26264_45564del19301) and XmnI-Gγ site in the third patient, and of only XmnI-Gγ site in the fourth patient. Conclusion: These family studies proved the fact that co-existence of SEA-αO thalassemia and Hb Constant Spring in HbE/βO-thalassemia could lead to mild clinical severity. Minimal effect of XmnI-Gγ site on clinical symptoms of this disease was emphasized. This information should be useful in prenatal diagnosis of HbE/β-thalassemia.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"50 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139112830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Panda, K. L. Mahanta, Jitendra kumar Pati, Soumya subhashree Satapathy, Ruchi Bhuyan
Background: Many studies employed machine learning (ML) to forecast the prognosis of breast cancer (BC) patients and discovered that the ML model showed high individualized forecasting ability. Breast cancer is the most frequent kind of carcinoma in women globally and ranks as the leading cause of death in women. Objectives: This study intends to use the Surveillance, Epidemiology, and End Results dataset to categorize breast carcinoma cases’ alive and dead conditions. Deep learning and machine learning have been extensively utilized in clinical studies to address various categorization problems due to their ability to manage massive data sets in an organized manner. Pre-processing the data allows it to be visualized and analyzed for making critical choices. This study describes a realistic machine learning-based strategy for categorizing the SEER breast cancer dataset. Materials and methods: We employed classification and machine learning algorithms to classify breast cancer mortality. Four well-known classification ML algorithms were employed in this study. To identify risk factors, we employed multivariate analysis using the data set. Results: The decision tree performed the best accuracy (0.914) among all the models. T4 stage (β=1.4, p<0.001, OR=4.22, 95% CI (2.06-8.64), N2 stage (β=0.39, p=0.008, OR= 1.49, 95% CI (1.111-1.997) found to be major risk factors for breast cancer mortality using multivariate analysis. Conclusion: The significant prognostic variables affecting the breast carcinoma survival rates reported in the current research are relevant and might be turned into decision support systems in the medical realm.
背景：许多研究利用机器学习（ML）预测乳腺癌（BC）患者的预后，发现ML模型显示出较高的个体化预测能力。乳腺癌是全球女性最常见的一种癌症，也是女性死亡的主要原因。研究目的本研究旨在利用监测、流行病学和最终结果数据集对乳腺癌病例的存活和死亡情况进行分类。深度学习和机器学习能够以有组织的方式管理海量数据集，因此已被广泛应用于临床研究，以解决各种分类问题。通过对数据进行预处理，可以对数据进行可视化分析，从而做出关键选择。本研究介绍了基于机器学习的 SEER 乳腺癌数据集分类策略。材料和方法：我们采用分类和机器学习算法对乳腺癌死亡率进行分类。本研究采用了四种著名的分类 ML 算法。为了确定风险因素，我们使用数据集进行了多变量分析。研究结果在所有模型中，决策树的准确率最高（0.914）。多变量分析发现，T4 阶段（β=1.4，p<0.001，OR=4.22，95% CI (2.06-8.64)）、N2 阶段（β=0.39，p=0.008，OR=1.49，95% CI (1.111-1.997)）是乳腺癌死亡率的主要风险因素。结论当前研究中报告的影响乳腺癌存活率的重要预后变量具有相关性，可转化为医学领域的决策支持系统。
{"title":"Development of prognostic model and multivariate analysis for breast cancer survival patients using SEER database","authors":"N. Panda, K. L. Mahanta, Jitendra kumar Pati, Soumya subhashree Satapathy, Ruchi Bhuyan","doi":"10.12982/jams.2024.008","DOIUrl":"https://doi.org/10.12982/jams.2024.008","url":null,"abstract":"Background: Many studies employed machine learning (ML) to forecast the prognosis of breast cancer (BC) patients and discovered that the ML model showed high individualized forecasting ability. Breast cancer is the most frequent kind of carcinoma in women globally and ranks as the leading cause of death in women. Objectives: This study intends to use the Surveillance, Epidemiology, and End Results dataset to categorize breast carcinoma cases’ alive and dead conditions. Deep learning and machine learning have been extensively utilized in clinical studies to address various categorization problems due to their ability to manage massive data sets in an organized manner. Pre-processing the data allows it to be visualized and analyzed for making critical choices. This study describes a realistic machine learning-based strategy for categorizing the SEER breast cancer dataset. Materials and methods: We employed classification and machine learning algorithms to classify breast cancer mortality. Four well-known classification ML algorithms were employed in this study. To identify risk factors, we employed multivariate analysis using the data set. Results: The decision tree performed the best accuracy (0.914) among all the models. T4 stage (β=1.4, p<0.001, OR=4.22, 95% CI (2.06-8.64), N2 stage (β=0.39, p=0.008, OR= 1.49, 95% CI (1.111-1.997) found to be major risk factors for breast cancer mortality using multivariate analysis. Conclusion: The significant prognostic variables affecting the breast carcinoma survival rates reported in the current research are relevant and might be turned into decision support systems in the medical realm.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"50 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139112919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Panda, K. L. Mahanta, Jitendra kumar Pati, Soumya subhashree Satapathy, Ruchi Bhuyan
Background: Many studies employed machine learning (ML) to forecast the prognosis of breast cancer (BC) patients and discovered that the ML model showed high individualized forecasting ability. Breast cancer is the most frequent kind of carcinoma in women globally and ranks as the leading cause of death in women. Objectives: This study intends to use the Surveillance, Epidemiology, and End Results dataset to categorize breast carcinoma cases’ alive and dead conditions. Deep learning and machine learning have been extensively utilized in clinical studies to address various categorization problems due to their ability to manage massive data sets in an organized manner. Pre-processing the data allows it to be visualized and analyzed for making critical choices. This study describes a realistic machine learning-based strategy for categorizing the SEER breast cancer dataset. Materials and methods: We employed classification and machine learning algorithms to classify breast cancer mortality. Four well-known classification ML algorithms were employed in this study. To identify risk factors, we employed multivariate analysis using the data set. Results: The decision tree performed the best accuracy (0.914) among all the models. T4 stage (β=1.4, p<0.001, OR=4.22, 95% CI (2.06-8.64), N2 stage (β=0.39, p=0.008, OR= 1.49, 95% CI (1.111-1.997) found to be major risk factors for breast cancer mortality using multivariate analysis. Conclusion: The significant prognostic variables affecting the breast carcinoma survival rates reported in the current research are relevant and might be turned into decision support systems in the medical realm.
背景：许多研究利用机器学习（ML）预测乳腺癌（BC）患者的预后，发现ML模型显示出较高的个体化预测能力。乳腺癌是全球女性最常见的一种癌症，也是女性死亡的主要原因。研究目的本研究旨在利用监测、流行病学和最终结果数据集对乳腺癌病例的存活和死亡情况进行分类。深度学习和机器学习能够以有组织的方式管理海量数据集，因此已被广泛应用于临床研究，以解决各种分类问题。通过对数据进行预处理，可以对数据进行可视化分析，从而做出关键选择。本研究介绍了基于机器学习的 SEER 乳腺癌数据集分类策略。材料和方法：我们采用分类和机器学习算法对乳腺癌死亡率进行分类。本研究采用了四种著名的分类 ML 算法。为了确定风险因素，我们使用数据集进行了多变量分析。研究结果在所有模型中，决策树的准确率最高（0.914）。多变量分析发现，T4 阶段（β=1.4，p<0.001，OR=4.22，95% CI (2.06-8.64)）、N2 阶段（β=0.39，p=0.008，OR=1.49，95% CI (1.111-1.997)）是乳腺癌死亡率的主要风险因素。结论当前研究中报告的影响乳腺癌存活率的重要预后变量具有相关性，可转化为医学领域的决策支持系统。
{"title":"Development of prognostic model and multivariate analysis for breast cancer survival patients using SEER database","authors":"N. Panda, K. L. Mahanta, Jitendra kumar Pati, Soumya subhashree Satapathy, Ruchi Bhuyan","doi":"10.12982/jams.2024.008","DOIUrl":"https://doi.org/10.12982/jams.2024.008","url":null,"abstract":"Background: Many studies employed machine learning (ML) to forecast the prognosis of breast cancer (BC) patients and discovered that the ML model showed high individualized forecasting ability. Breast cancer is the most frequent kind of carcinoma in women globally and ranks as the leading cause of death in women. Objectives: This study intends to use the Surveillance, Epidemiology, and End Results dataset to categorize breast carcinoma cases’ alive and dead conditions. Deep learning and machine learning have been extensively utilized in clinical studies to address various categorization problems due to their ability to manage massive data sets in an organized manner. Pre-processing the data allows it to be visualized and analyzed for making critical choices. This study describes a realistic machine learning-based strategy for categorizing the SEER breast cancer dataset. Materials and methods: We employed classification and machine learning algorithms to classify breast cancer mortality. Four well-known classification ML algorithms were employed in this study. To identify risk factors, we employed multivariate analysis using the data set. Results: The decision tree performed the best accuracy (0.914) among all the models. T4 stage (β=1.4, p<0.001, OR=4.22, 95% CI (2.06-8.64), N2 stage (β=0.39, p=0.008, OR= 1.49, 95% CI (1.111-1.997) found to be major risk factors for breast cancer mortality using multivariate analysis. Conclusion: The significant prognostic variables affecting the breast carcinoma survival rates reported in the current research are relevant and might be turned into decision support systems in the medical realm.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"50 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139113111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Tatu, Wachirawit Tondee, Pornchai Khamtong, Lamplimas Tangphan, Jidapa Jaitiang
Background: Four university students of northern Thai descent were found to be HbE/βO-thalassemia. However, they all had a mild form of this disease, categorized as Non-Transfusion Dependent Thalassemia. Objectives: To analyze involvement of types of β-globin mutations, α-thalassemia, and XmnI-Gγ site in mild clinical symptoms observed in four Thai non-transfusion dependent HbE/βO-thalassemia cases. Materials and methods: EDTA blood samples were collected from the patients and their family members after signing the informed consent. Automated complete blood count with blood smear examination, hemoglobin typing, molecular analysis for α and β-globin mutations, β-globin gene haplotypes, and XmnI-Gγ site were performed on all blood samples. In addition, nucleotide sequencing of β-globin gene and globin chain separation were performed for patient#3 and their parents. Results: The first three patients had hemoglobin levels ranging 8.5-11.2 g/dL, while the fourth patient had hemoglobin level of 6.7 g/dL. The first and fourth patients were compound heterozygote for βE (HBB:c.79G>A) and β17 (HBB:c.52A>T) alleles with typical hemoglobin pattern of EF. The second patient was compound heterozygote for βE and β41/42 (HBB:c.126_129delCTTT) alleles also with typical hemoglobin pattern of EF. The third patient was compound heterozygote of βE and βIVS1-1(HBB:c.92+1G>T), however, with atypical hemoglobin pattern of EE. Family analysis found co-inheritance of Hb Constant Spring (HBA2:c.427T>C) and the XmnI-Gγ site (T at rs7482144) in the first two patients, of SEA-αO thalassemia (NG_000006.1:g.26264_45564del19301) and XmnI-Gγ site in the third patient, and of only XmnI-Gγ site in the fourth patient. Conclusion: These family studies proved the fact that co-existence of SEA-αO thalassemia and Hb Constant Spring in HbE/βO-thalassemia could lead to mild clinical severity. Minimal effect of XmnI-Gγ site on clinical symptoms of this disease was emphasized. This information should be useful in prenatal diagnosis of HbE/β-thalassemia.
{"title":"Non-transfusion dependent HbE/βO-thalassemia as the results of co-existent SEA-αO thalassemia, Hb Constant Spring, and XmnI-Gγ site: Thai family studies","authors":"T. Tatu, Wachirawit Tondee, Pornchai Khamtong, Lamplimas Tangphan, Jidapa Jaitiang","doi":"10.12982/jams.2024.006","DOIUrl":"https://doi.org/10.12982/jams.2024.006","url":null,"abstract":"Background: Four university students of northern Thai descent were found to be HbE/βO-thalassemia. However, they all had a mild form of this disease, categorized as Non-Transfusion Dependent Thalassemia. Objectives: To analyze involvement of types of β-globin mutations, α-thalassemia, and XmnI-Gγ site in mild clinical symptoms observed in four Thai non-transfusion dependent HbE/βO-thalassemia cases. Materials and methods: EDTA blood samples were collected from the patients and their family members after signing the informed consent. Automated complete blood count with blood smear examination, hemoglobin typing, molecular analysis for α and β-globin mutations, β-globin gene haplotypes, and XmnI-Gγ site were performed on all blood samples. In addition, nucleotide sequencing of β-globin gene and globin chain separation were performed for patient#3 and their parents. Results: The first three patients had hemoglobin levels ranging 8.5-11.2 g/dL, while the fourth patient had hemoglobin level of 6.7 g/dL. The first and fourth patients were compound heterozygote for βE (HBB:c.79G>A) and β17 (HBB:c.52A>T) alleles with typical hemoglobin pattern of EF. The second patient was compound heterozygote for βE and β41/42 (HBB:c.126_129delCTTT) alleles also with typical hemoglobin pattern of EF. The third patient was compound heterozygote of βE and βIVS1-1(HBB:c.92+1G>T), however, with atypical hemoglobin pattern of EE. Family analysis found co-inheritance of Hb Constant Spring (HBA2:c.427T>C) and the XmnI-Gγ site (T at rs7482144) in the first two patients, of SEA-αO thalassemia (NG_000006.1:g.26264_45564del19301) and XmnI-Gγ site in the third patient, and of only XmnI-Gγ site in the fourth patient. Conclusion: These family studies proved the fact that co-existence of SEA-αO thalassemia and Hb Constant Spring in HbE/βO-thalassemia could lead to mild clinical severity. Minimal effect of XmnI-Gγ site on clinical symptoms of this disease was emphasized. This information should be useful in prenatal diagnosis of HbE/β-thalassemia.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"50 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139113165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jitapa Chawawisuttikool, Chatchai Phirawatthakul, Warintun Thomchaita, Chatchai Tieachanpan, O. Prasartwuth
Background: To prevent running related injuries and return to sport activities, monitoring the running dynamic parameters (cadence, stride length, ground contact time and vertical oscillation) especially outdoor running is crucial. Previous studies investigated the reliability of these parameters in laboratory settings. However, the nature of outdoor runs is different (curve, uphill, other runners, etc.) and challenging in terms of equipment (simple) and environments (grass, asphalt, rubber, etc.). Therefore, the reliability of these parameters using a fitness watch synced with accelerometer needed to be investigated. Objective: To investigate the reliability of running parameters measured using fitness watches and accelerometers during outdoor runs. Materials and methods: 30 healthy volunteers (age 25.8±9.6 years, height 167.2±9.3 cm, weight 62.4±14.2 kg, and body mass index 22.2±3.8 kg/m2) participated in the study. They wore a fitness watch and attached a synced accelerometer at their pants. They completed 2 running laps (800 meters each) at their comfortable speeds. Resting periods were provided between laps. To control the speed for the second lap, the watch was set the maximum and minimum speed and set vibration and sound alarm mode. Running parameters include cadence, stride length, vertical oscillation, and ground contact time. Results: The reliability of the four running parameters (cadence, stride length, ground contact time, and vertical oscillation), indicated by the intraclass correlation coefficients (ICC (3,k)) was 0.94, 0.97, 0.98 and 0.99, respectively. Very high reliability values were confirmed. Conclusion: Using a fitness watch synced with an accelerometer during outdoor runs, running dynamic parameters (cadence, stride length, ground contact time, and vertical oscillation) illustrated very high levels of reliability.
{"title":"Reliability of running parameters using fitness watches synced with accelerometers during outdoor runs","authors":"Jitapa Chawawisuttikool, Chatchai Phirawatthakul, Warintun Thomchaita, Chatchai Tieachanpan, O. Prasartwuth","doi":"10.12982/jams.2024.019","DOIUrl":"https://doi.org/10.12982/jams.2024.019","url":null,"abstract":"Background: To prevent running related injuries and return to sport activities, monitoring the running dynamic parameters (cadence, stride length, ground contact time and vertical oscillation) especially outdoor running is crucial. Previous studies investigated the reliability of these parameters in laboratory settings. However, the nature of outdoor runs is different (curve, uphill, other runners, etc.) and challenging in terms of equipment (simple) and environments (grass, asphalt, rubber, etc.). Therefore, the reliability of these parameters using a fitness watch synced with accelerometer needed to be investigated. Objective: To investigate the reliability of running parameters measured using fitness watches and accelerometers during outdoor runs. Materials and methods: 30 healthy volunteers (age 25.8±9.6 years, height 167.2±9.3 cm, weight 62.4±14.2 kg, and body mass index 22.2±3.8 kg/m2) participated in the study. They wore a fitness watch and attached a synced accelerometer at their pants. They completed 2 running laps (800 meters each) at their comfortable speeds. Resting periods were provided between laps. To control the speed for the second lap, the watch was set the maximum and minimum speed and set vibration and sound alarm mode. Running parameters include cadence, stride length, vertical oscillation, and ground contact time. Results: The reliability of the four running parameters (cadence, stride length, ground contact time, and vertical oscillation), indicated by the intraclass correlation coefficients (ICC (3,k)) was 0.94, 0.97, 0.98 and 0.99, respectively. Very high reliability values were confirmed. Conclusion: Using a fitness watch synced with an accelerometer during outdoor runs, running dynamic parameters (cadence, stride length, ground contact time, and vertical oscillation) illustrated very high levels of reliability.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"51 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139113384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Damayanti Sethy, Surjeet Sahoo, S. Sahoo, Kshanaprava Mohakud
Background: Rehabilitation of upper limb impairments and functional deficits is a top goal in stroke rehabilitation. Alternative therapeutic methods may be developed to facilitate upper limb recovery. Priming prepares the brain for better action. When some therapies accompany Priming, it results in a change in behaviour at the performance level by improving the effect of Neuro-Rehabilitation Therapies and enhancing change in the neural process. Objectives: To investigate the efficacy of movement-based priming combined with task-specific training on upper limb recovery in patients after stroke. Materials and methods: Twenty-four subjects in the early phase of stroke, attending the Department of Neurology in a tertiary care hospital of Bhubaneswar, Odisha participated in a single-blind randomized controlled trial. 24 subjects after stroke were recruited to the study and randomly allocated to a control group receiving task-specific training only (TST) and an experimental group receiving Movement-Based Priming with task-specific training (MBP+TST). The control group received only task-specific training for 45 minutes per session three days a week for six weeks, while the experimental group received 15 minutes of priming and 30 minutes of task-specific training. Fugl-Mayer Assessment of upper extremity (FMA-UE)was used to measure upper extremity motor recovery, and the Motor Activity Log (MAL) was used to measure the use of arm and hand during activities of daily living at baseline and after six weeks of therapy. Results: Both the TST group and the MBP+TST group had significantly improved their capacity to move and use their upper limbs functionally (p<0.001). FMA-UE and MAL scores improved more favorably in the MBP+TST group than in the TST group (p<0.001). Conclusion: Priming in combination with task-specific training results in better upper limb recovery than task-specific training alone.
{"title":"Effect of movement-based priming combined with task specific training on upper limb recovery in patients after stroke","authors":"Damayanti Sethy, Surjeet Sahoo, S. Sahoo, Kshanaprava Mohakud","doi":"10.12982/jams.2024.009","DOIUrl":"https://doi.org/10.12982/jams.2024.009","url":null,"abstract":"Background: Rehabilitation of upper limb impairments and functional deficits is a top goal in stroke rehabilitation. Alternative therapeutic methods may be developed to facilitate upper limb recovery. Priming prepares the brain for better action. When some therapies accompany Priming, it results in a change in behaviour at the performance level by improving the effect of Neuro-Rehabilitation Therapies and enhancing change in the neural process. Objectives: To investigate the efficacy of movement-based priming combined with task-specific training on upper limb recovery in patients after stroke. Materials and methods: Twenty-four subjects in the early phase of stroke, attending the Department of Neurology in a tertiary care hospital of Bhubaneswar, Odisha participated in a single-blind randomized controlled trial. 24 subjects after stroke were recruited to the study and randomly allocated to a control group receiving task-specific training only (TST) and an experimental group receiving Movement-Based Priming with task-specific training (MBP+TST). The control group received only task-specific training for 45 minutes per session three days a week for six weeks, while the experimental group received 15 minutes of priming and 30 minutes of task-specific training. Fugl-Mayer Assessment of upper extremity (FMA-UE)was used to measure upper extremity motor recovery, and the Motor Activity Log (MAL) was used to measure the use of arm and hand during activities of daily living at baseline and after six weeks of therapy. Results: Both the TST group and the MBP+TST group had significantly improved their capacity to move and use their upper limbs functionally (p<0.001). FMA-UE and MAL scores improved more favorably in the MBP+TST group than in the TST group (p<0.001). Conclusion: Priming in combination with task-specific training results in better upper limb recovery than task-specific training alone.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"53 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139113521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seethammagari Mamatha Ramani, Penchalaneni Josthna, K. R. Padma
The sixth most common recurrent malignancy worldwide is ovarian cancer in women, and it causes more women to die compared to any other issue impacting the female reproductive system. Ovarian cancer has several histological subgroups differing in clinical traits, risk factors, cell sources, molecular makeups, and treatment possibilities. There is no effective screening procedure, and it is typically discovered at a late stage. Newly found cancer is currently treated with platinum-based chemotherapy and cytoreductive surgery. Due to its recurrence and late diagnosis, ovarian cancer has the highest fatality rates in contrast to all gynecological cancers. The discipline of medical nanotechnology has made great strides in recent years in resolving issues and enhancing the detection and treatment of various illnesses, including cancer. However, most studies and recent reviews on nanotechnology are devoted to how it might be utilized to treat other tumors or disorders. This review’s main objective was the precise diagnosis and treatment of ovarian cancer using nanoscale drug delivery systems. Various nanocarrier systems, such as dendrimers, nanoparticles, liposomes, nanocapsules, and nano micelles, have been discussed. Additionally, we explore how the potency of the combination of immunotherapy and nanotechnology may help to overcome the current therapeutic constraints connected with each application and reveal a novel paradigm in cancer therapy. The unique nanotherapeutic approaches that have demonstrated promising outcomes in preclinical in vivo research are highlighted, along with new nanoformulations actively advancing into clinical trials. Additionally, the possible use of nanomaterials in diagnostic imaging methods and the capacity to use nanotechnology for early ovarian cancer detection are also highlighted.
{"title":"Emerging updates on tracking new landscapes in nanotechnology for the diagnosis and ovarian cancer therapy","authors":"Seethammagari Mamatha Ramani, Penchalaneni Josthna, K. R. Padma","doi":"10.12982/jams.2024.014","DOIUrl":"https://doi.org/10.12982/jams.2024.014","url":null,"abstract":"The sixth most common recurrent malignancy worldwide is ovarian cancer in women, and it causes more women to die compared to any other issue impacting the female reproductive system. Ovarian cancer has several histological subgroups differing in clinical traits, risk factors, cell sources, molecular makeups, and treatment possibilities. There is no effective screening procedure, and it is typically discovered at a late stage. Newly found cancer is currently treated with platinum-based chemotherapy and cytoreductive surgery. Due to its recurrence and late diagnosis, ovarian cancer has the highest fatality rates in contrast to all gynecological cancers. The discipline of medical nanotechnology has made great strides in recent years in resolving issues and enhancing the detection and treatment of various illnesses, including cancer. However, most studies and recent reviews on nanotechnology are devoted to how it might be utilized to treat other tumors or disorders. This review’s main objective was the precise diagnosis and treatment of ovarian cancer using nanoscale drug delivery systems. Various nanocarrier systems, such as dendrimers, nanoparticles, liposomes, nanocapsules, and nano micelles, have been discussed. Additionally, we explore how the potency of the combination of immunotherapy and nanotechnology may help to overcome the current therapeutic constraints connected with each application and reveal a novel paradigm in cancer therapy. The unique nanotherapeutic approaches that have demonstrated promising outcomes in preclinical in vivo research are highlighted, along with new nanoformulations actively advancing into clinical trials. Additionally, the possible use of nanomaterials in diagnostic imaging methods and the capacity to use nanotechnology for early ovarian cancer detection are also highlighted.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139113525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cleft palate is a congenital disability affecting the palate’s structure and function, which may lead to delayed speech and language development and communication disorders. There is a shortage of speech therapists in Thailand. Therefore, developing a manual for speech and language treatment for the parents of children with a cleft palate would be an essential early intervention that parents could perform. Objectives: This research aimed to develop a speech and language treatment manual for parents of children with cleft palate ages 0-3 years old and evaluate the manual’s effectiveness, satisfaction, and feedback. Materials and methods: This research was divided into Phase 1, which involved developing a speech and language treatment manual for parents of children with cleft palate ages 0-3 years old and assessing its validity and reliability. Phase 2 tested the manual’s effectiveness by conducting a three-month of 16 participants, who were divided into two groups: A control group without the manual and an experimental group with the manual and phase 3 data analysis. Results: The content validity of the manual and satisfaction of the questionnaires were found to have a content validity index of 0.87 and 0.92, respectively. The total language and speech development scores before and after participating between groups found a statistically significant difference. After participating, the number of the experimental group who passed the 90th percentile of language development was higher than the control group. The language between the children and parents showed that the experimental group displayed more communication skills than the control group. Conclusion: The speech and language treatment manual for parents of children with cleft palate ages 0-3 years old could stimulate the language and speech development of the experimental group more effectively than the control group that did not receive the manual.
{"title":"The Development of manual for speech and language treatment for parents of children with cleft palate ages 0-3 years old","authors":"Pechcharat Jaiyong, Phuanjai Rattakorn, Supaporn Chinchai","doi":"10.12982/jams.2024.007","DOIUrl":"https://doi.org/10.12982/jams.2024.007","url":null,"abstract":"Background: Cleft palate is a congenital disability affecting the palate’s structure and function, which may lead to delayed speech and language development and communication disorders. There is a shortage of speech therapists in Thailand. Therefore, developing a manual for speech and language treatment for the parents of children with a cleft palate would be an essential early intervention that parents could perform. Objectives: This research aimed to develop a speech and language treatment manual for parents of children with cleft palate ages 0-3 years old and evaluate the manual’s effectiveness, satisfaction, and feedback. Materials and methods: This research was divided into Phase 1, which involved developing a speech and language treatment manual for parents of children with cleft palate ages 0-3 years old and assessing its validity and reliability. Phase 2 tested the manual’s effectiveness by conducting a three-month of 16 participants, who were divided into two groups: A control group without the manual and an experimental group with the manual and phase 3 data analysis. Results: The content validity of the manual and satisfaction of the questionnaires were found to have a content validity index of 0.87 and 0.92, respectively. The total language and speech development scores before and after participating between groups found a statistically significant difference. After participating, the number of the experimental group who passed the 90th percentile of language development was higher than the control group. The language between the children and parents showed that the experimental group displayed more communication skills than the control group. Conclusion: The speech and language treatment manual for parents of children with cleft palate ages 0-3 years old could stimulate the language and speech development of the experimental group more effectively than the control group that did not receive the manual.","PeriodicalId":298884,"journal":{"name":"Journal of Associated Medical Sciences","volume":"50 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139113569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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