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Pitfalls in the diagnosis of glioblastoma 胶质母细胞瘤的诊断陷阱
Pub Date : 2023-03-16 DOI: 10.33962/roneuro-2023-001
Bica Dorin, Ion Poeata
Glioblastoma (GBM) is one of the most dreadful human cancers having a literature-reported median of life of 14 months with maximal treatment. The correct diagnosis is of crucial importance for the best chances of treatment. Misdiagnosis is uncommon, but seen in daily practice, and leads to important delays for patients. This paper will discuss the delays found in glioblastoma diagnosis in a series of 60 newly diagnosed patients. Four out of 60 patients had a delay of more than 6 weeks of treatment initiation, as at first imaging, GBM was not suspected as a diagnosis.
胶质母细胞瘤(GBM)是最可怕的人类癌症之一,据文献报道,在最大限度的治疗下,中位生存期为14个月。正确的诊断对于获得最佳治疗机会至关重要。误诊是不常见的,但在日常实践中看到,并导致重要延误的病人。本文将讨论60例新诊断的胶质母细胞瘤患者的延迟诊断。60例患者中有4例延迟治疗超过6周,因为在首次成像时,GBM未被怀疑为诊断。
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引用次数: 0
The challenges and opportunities of patient safety culture in neurosurgical departments from the Republic of Moldova 摩尔多瓦共和国神经外科患者安全文化的挑战与机遇
Pub Date : 2023-03-16 DOI: 10.33962/roneuro-2023-002
Silvia Danu
Neurosurgery is a high-risk speciality, so the Patient Safety Culture should become a priority to improve patient safety and the quality of medical care. The purpose of the study was to explore the perception of Patient Safety Culture (PSC) among the staff in the neurosurgical departments of the Republic of Moldova. A cross-sectional study was conducted in neurosurgical departments using the Hospital Survey on Patient Safety Culture (HSOPSC). Descriptive statistics were carried out, comprising the Cronbach "?" coefficient, frequency of positive answers (PPRs), and level of minimum and maximum of 95% confidential interval. PPRs by question and dimension were analysed overall and classified according to the Harrington scale. Medical staff from five hospitals voluntarily participated in the study. Most of the respondents rated the patient's safety grade as excellent and very good. The value of the frequency of positive responses to the dimensions of the survey varies between 37.3% (nonpunitive response to error) and 85.0% (teamwork within units). The dimensions with the highest score of the PPRs stand out: „teamwork within units”, „organizational learning- continuous improvement” and „supervisor/manager expectations and actions promoting patient safety”. The dimension with a high score of PPRs was „feedback and communication about error”. The dimensions with a satisfactory score of the PPRs were „handoffs and transitions”, „frequency of events reported”, „management support for patient safety”, „teamwork across units”, „communication openness”, „overall perceptions on patient safety”, „non-punitive response to errors” and „staffing”. For the first time in the Republic of Moldova, the perception of patient safety culture in neurosurgery departments was studied. The results reflect the positive attitude of the staff towards most dimensions of the patient safety culture. The study made it possible to highlight the strong and vulnerable points of the patient safety culture in neurosurgical departments from Moldova.
神经外科是一个高风险的专科,因此患者安全文化应成为一个优先事项,以提高患者安全和医疗质量。本研究的目的是探讨摩尔多瓦共和国神经外科工作人员对患者安全文化(PSC)的看法。 采用医院患者安全培养调查(HSOPSC)在神经外科科室进行了横断面研究。描述性统计包括Cronbach“?”系数、积极回答频率(PPRs)和95%保密区间的最小和最大水平。按问题和维度对PPRs进行综合分析,并按哈林顿量表进行分类。 来自五家医院的医务人员自愿参与了研究。大多数受访者认为患者的安全等级为优秀和非常好。对调查维度的积极回应的频率值在37.3%(对错误的非惩罚性回应)和85.0%(单位内的团队合作)之间变化。得分最高的范畴包括“单位内的团队合作”、“组织学习-持续改善”和“主管/经理对促进病人安全的期望和行动”。PPRs得分较高的维度是“关于错误的反馈与沟通”。PPRs得分令人满意的维度是“交接和过渡”、“报告事件的频率”、“对患者安全的管理支持”、“跨单位团队合作”、“沟通开放性”、“对患者安全的总体看法”、“对错误的非惩罚性反应”和“人员配置”。 摩尔多瓦共和国首次对神经外科患者安全文化的认知进行了研究。结果反映了工作人员对患者安全文化的大多数维度的积极态度。该研究突出了摩尔多瓦神经外科患者安全文化的长处和弱点。
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引用次数: 0
Mature cystic teratoma of spinal cord in an adult 成人脊髓成熟囊性畸胎瘤
Pub Date : 2023-03-16 DOI: 10.33962/roneuro-2023-017
Rajneesh Misra, Sushil Kumar, Sandeep Sharma
Aim: Reporting a rare case of mature cystic teratoma of spinal cord in an adult Background: Teratomas of the central nervous system are rare lesions accounting for less than 0.5-2% of all CNS tumors. Most of these are found in pediatric age group and favor sellar - suprasellar, pineal and sacro-coccygeal regions. Their occurrence in spinal cord in an adult is incredibly rare. Case presentation: A 22-year-old male presented with low back ache and weakness of both lower limbs. Clinical examination and radiological workup revealed presence of a cystic lesion causing diffuse enlargement of the cord from L1 to L5-S1. Histo-pathological examination of the excised lesion revealed it to be teratoma. Conclusion and clinical significance: Mature teratoma of the spinal cord in adults is extremely rare occurrence. However, this diagnosis should be kept in mind when evaluating a cystic lesion of cord even in adults. Maximal safe resection of the lesion results in prolonged deficit-free survival.
目的:报告一例罕见的成人脊髓成熟囊性畸胎瘤 背景:中枢神经系统畸胎瘤是一种罕见的病变,约占所有中枢神经系统肿瘤的0.5-2%。这些大多发生在儿童年龄组,并倾向于鞍上、松果体和骶尾骨区域。它们在成人脊髓中的发生是非常罕见的。 病例介绍:22岁男性,表现为腰痛及双下肢无力。临床检查和放射检查显示存在囊性病变,导致从L1到L5-S1的脊髓弥漫性扩大。切除病变组织病理检查显示为畸胎瘤。 结论及临床意义:成人脊髓成熟畸胎瘤极为罕见。然而,在评估脊髓囊性病变时,即使在成人中也应牢记这一诊断。最大限度的安全切除病变可延长无缺陷生存期。
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 Background: Teratomas of the central nervous system are rare lesions accounting for less than 0.5-2% of all CNS tumors. Most of these are found in pediatric age group and favor sellar - suprasellar, pineal and sacro-coccygeal regions. Their occurrence in spinal cord in an adult is incredibly rare.
 Case presentation: A 22-year-old male presented with low back ache and weakness of both lower limbs. Clinical examination and radiological workup revealed presence of a cystic lesion causing diffuse enlargement of the cord from L1 to L5-S1. Histo-pathological examination of the excised lesion revealed it to be teratoma.
 Conclusion and clinical significance: Mature teratoma of the spinal cord in adults is extremely rare occurrence. However, this diagnosis should be kept in mind when evaluating a cystic lesion of cord even in adults. Maximal safe resection of the lesion results in prolonged deficit-free survival.","PeriodicalId":30188,"journal":{"name":"Romanian Neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135553987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incomplete Currarino triad in an adult woman 成年女性不完整的柯拉里诺三和弦
Pub Date : 2023-03-16 DOI: 10.33962/roneuro-2023-018
Rasha A. Al-Youzbaki, Emad Hazim Mahmoud, Zahraa A. Alsubaihawi, Mohammed A. Almeran, Saja A. Albanaa, Samer S. Hoz
Introduction: Currarino Syndrome (CS) is a rare entity characterized by a triad of sacral agenesis, anorectal malformations, and pre-sacral masses. CS is typically diagnosed during the first decade of life. Case Description: We present a rare case of incomplete Currarino syndrome manifesting in a 36-year-old lady who presented with back pain, urinary retention, anal paresthesia, and lower limb weakness. The patient underwent multiple laminectomies and partial resection of an epidermoid cyst and regained function. Conclusion: Although rare, the possibility of Currarino syndrome should be entertained in adult patients with lower lumbosacral symptoms and a pre-sacral mass. A thorough physical examination and strategic pre-operative planning are mandatory to maximize patient outcomes.
简介:Currarino综合征(CS)是一种罕见的以骶骨发育不全、肛肠畸形和骶骨前肿块为特征的疾病。CS通常在生命的头十年被诊断出来。病例描述:我们报告一例罕见的不完全Currarino综合征,患者为一名36岁的女性,表现为背痛、尿潴留、肛门感觉异常和下肢无力。患者接受了多次椎板切除术和部分切除表皮样囊肿并恢复功能。 结论:虽然罕见,但有腰骶下部症状和骶前肿块的成人患者应考虑Currarino综合征的可能性。全面的体格检查和战略性的术前计划是最大限度地提高患者预后的必要条件。
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 Case Description: We present a rare case of incomplete Currarino syndrome manifesting in a 36-year-old lady who presented with back pain, urinary retention, anal paresthesia, and lower limb weakness. The patient underwent multiple laminectomies and partial resection of an epidermoid cyst and regained function.
 Conclusion: Although rare, the possibility of Currarino syndrome should be entertained in adult patients with lower lumbosacral symptoms and a pre-sacral mass. A thorough physical examination and strategic pre-operative planning are mandatory to maximize patient outcomes.","PeriodicalId":30188,"journal":{"name":"Romanian Neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135553989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anterior approach arthrodesis - ALIF with use of a titanium cage for treatment of postoperative spondylodiscitis after lumbar microdiscectomy 前路关节融合术-使用钛笼治疗腰椎微椎间盘切除术后的术后椎间盘炎
Pub Date : 2023-03-15 DOI: 10.33962/roneuro-2023-005
Sofia Ramos Soares, Alexandre Lacerda, Júlia Richard Gondim Bezerra Cavalcanti, Thiago Gomes Martins, Giacomo De Freitas Souza, Jim Umberto Cantisani Neto
Introduction. Infectious spondylodiscitis has an incidence of 0.21-3.6%. The best intervention should be individualized, using antibiotics only or combining them with stabilizing surgeries. Case presentation. A 38-year-old man presented with lumbosciatalgia, severe pain and inability to ambulate. Magnetic resonance imaging (MRI) of the lumbar spine showed L5-S1 extruded disc herniation and the patient underwent endoscopic microdiscectomy with complete remission of symptoms. After two weeks, he reported severe low back pain and a return of difficulty to walk. Laboratory tests showed an increase in CRP and ESR. MRI showed signs of lumbar spondylodiscitis. The patient started on broad-spectrum intravenous antibiotic therapy. He evolved with improvement in laboratory parameters and maintenance of low back pain. Due to the failure of conservative treatment, anterior approach arthrodesis (ALIF) was chosen, with the complete improvement of the low back pain and the return of the ability to walk. Discussion. Postoperative spondylodiscitis’ frequency depends on the invasiveness of the operation and the type of surgery performed. The most likely source of infection is direct inoculation by virulent pathogens during surgery. A diagnosis delay of more than two months is considered a risk factor for generating adverse results. A Conservative approach is indicated for the patient who is neurologically intact and with minimal bone destruction. Surgical indications are the presence of neurological deficits, intraspinal abscesses, extensive bone destruction, and failure of conservative management. ALIF is supported in the literature because it allows wide exposure of the entire disc space through efficient access to the spine with the complete evacuation of the disc, avoiding dissection of perineural scar tissue and preserving the articular facets. Conclusion. Early diagnosis and treatment are crucial, although there is still no consensus about the best treatment approach. The use of a titanium cage with a bioglass graft had a good response in pain and infection control in our case.
介绍。感染性脊柱炎的发病率为0.21-3.6%。最好的干预应该是个体化的,仅使用抗生素或将抗生素与稳定手术相结合。案例演示。男,38岁,腰痛,剧烈疼痛,不能行走。腰椎磁共振成像(MRI)显示L5-S1椎间盘突出,患者行内镜下显微椎间盘切除术,症状完全缓解。两周后,他报告了严重的腰痛和行走困难。实验室检查显示CRP和ESR升高。MRI显示腰椎椎间盘炎征象。病人开始接受广谱静脉抗生素治疗。他随着实验室参数的改善和腰痛的维持而发展。由于保守治疗失败,选择前路关节融合术(ALIF),腰痛完全改善,行走能力恢复。讨论。术后脊柱炎的发生频率取决于手术的侵入性和手术的类型。最可能的感染源是手术过程中毒力病原体的直接接种。诊断延迟超过两个月被认为是产生不良结果的危险因素。对于神经系统完整且骨破坏最小的患者,建议采用保守入路。手术指征包括神经功能缺损、椎管内脓肿、大面积骨破坏和保守治疗失败。ALIF在文献中得到了支持,因为它可以通过有效地进入脊柱并完全清除椎间盘,从而广泛暴露整个椎间盘空间,避免了神经周围瘢痕组织的剥离并保留了关节面。结论。早期诊断和治疗至关重要,尽管对最佳治疗方法仍未达成共识。在我们的病例中,使用钛笼与生物玻璃移植物在疼痛和感染控制方面有很好的反应。
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引用次数: 0
An insight into artificial intelligence and its role in neurosurgery 对人工智能及其在神经外科中的作用的洞察
Pub Date : 2023-03-15 DOI: 10.33962/roneuro-2023-021
Ahtesham Khizar
To acquire a wide range of technical skills, neurosurgeons undergo extensive and drawn-out training. Additionally, neurosurgery necessitates a significant amount of preoperative, intraoperative, and postoperative clinical data collection, decision-making, care, and recovery. The significance of artificial intelligence in neurosurgery has significantly increased during the past ten years. The potential of artificial intelligence to improve diagnostic and prognostic outcomes in neurosurgery is quite promising. It is important to clinical therapy because it helps neurosurgeons make crucial decisions during surgical interventions to improve patient outcomes and it enhances their abilities to give patients the finest interventional and non-interventional care possible. Furthermore, the acquisition, processing, and storage of clinical and experimental data are all greatly influenced by artificial intelligence. Its application in neurosurgery can lower surgical care expenses and offer top-notch medical treatment to a larger population. This article examines the use of artificial intelligence in preoperative, intraoperative, and postoperative care for both interventional and non-interventional aspects of neurosurgery, including diagnosis, clinical decision-making, surgical operation, prognosis, data collection, and research in the field.
为了获得广泛的技术技能,神经外科医生接受了广泛而持久的训练。此外,神经外科需要大量的术前、术中和术后临床数据收集、决策、护理和恢复。近十年来,人工智能在神经外科中的重要性显著提高。人工智能在改善神经外科诊断和预后结果方面的潜力是相当有希望的。它对临床治疗非常重要,因为它可以帮助神经外科医生在手术干预过程中做出关键决定,以改善患者的预后,并提高他们为患者提供最好的介入和非介入治疗的能力。此外,临床和实验数据的获取、处理和存储都受到人工智能的极大影响。它在神经外科中的应用可以降低外科护理费用,为更多的人群提供一流的医疗服务。本文探讨了人工智能在神经外科介入和非介入方面的术前、术中和术后护理中的应用,包括诊断、临床决策、手术、预后、数据收集和该领域的研究。
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引用次数: 0
Wandering intracranial bullet 游离颅内子弹
Pub Date : 2023-03-15 DOI: 10.33962/roneuro-2023-009
Anand Sharma, A. Shukla, Avinash Sharma
Multidirectional migration of bullets has been reported infrequently in the literature. The Surgical retrieval of an intracranial migrating bullet is suggested because of its capacity to produce an additional neurological deficit. Intraoperative image guidance using the C arm is indicated in all intracranial migrating metallic foreign bodies following gunshot injury. A rare case of migrating bullet fragment in its trajectory with the migration of metallic fragment in both cerebral hemispheres is reported, and relevant literature is reviewed.
子弹的多向迁移在文献中很少报道。手术取出颅内移动子弹是建议,因为它的能力产生额外的神经功能障碍。术中C臂图像引导适用于枪伤后所有颅内金属异物的迁移。本文报道了一例罕见的子弹破片沿弹道迁移并伴有双脑金属碎片迁移的病例,并对相关文献进行了综述。
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引用次数: 0
Intramedullary cavernoma 髓内钙化
Pub Date : 2023-03-15 DOI: 10.33962/roneuro-2023-010
Mamadou Bata Dianka, Farida Abdoulkader Guedi, Djama Houssein Omar, Goumaneh Omar Houssein, Filsan Omar Ali
The cavernoma is a vascular malformation made of well-circumscribed agglomeration of pseudo-capillaries. Bone marrow localization is rare and accounts for about 5% of spinal cord vascular lesions. Clinical symptomatology is marked by progressive bone marrow compression syndrome. The diagnosis is strongly evoked in magnetic resonance imaging and confirmed by histology. The management is essentially surgical. We report a case of bone marrow cavernoma in a 38-year-old man seen in consultation, paraplegic for 2 weeks. The spinal cord MRI revealed a lesion opposite D11, evoking a cavernoma. The patient was operated on with total removal of the lesion; histology confirmed the diagnosis of cavernoma. The immediate post-operative follow-up was marked by the partial recovery of the deficit. We discuss, through this clinical case, the clinical, radiological and especially therapeutic aspects of the medullary cavernoma.
海绵状瘤是一种血管畸形,由界限分明的假毛细血管聚集而成。骨髓定位是罕见的,约占脊髓血管病变的5%。临床症状以进行性骨髓压迫综合征为特征。诊断强烈唤起磁共振成像和组织学证实。治疗基本上是外科手术。我们报告一例骨髓海绵状瘤在一个38岁的男子看咨询,截瘫2周。脊髓MRI显示D11对面病变,提示海绵状瘤。手术切除病灶;组织学证实了海绵瘤的诊断。术后立即随访,缺损部分恢复。我们讨论,通过这个临床病例,临床,放射学和特别是治疗方面的髓样海绵状瘤。
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引用次数: 0
Common peroneal neuroma in continuity with complete foot drop secondary to a bullet fragment injury 继发于子弹碎片伤的完全性足部下垂的连续的常见腓神经瘤
Pub Date : 2023-03-15 DOI: 10.33962/roneuro-2023-011
Adnan Khaliq, Ahtesham Khizar
Background. Common peroneal nerve (CPN) injuries are generally common but they are uncommon due to gunshot injuries and are associated with poor motor outcomes. Managing neuroma-in-continuity is still challenging because there are currently no accepted standards for deciding on the most effective course of treatment or estimating the time needed for repair. Treatment options for a neuroma-in-continuity include neurolysis, neuroma resection with interposition, end-to-side nerve grafting, and bypass grafting. Case presentation. A 40-year-old man presented with findings of complete right foot drop due to an 8-month-old firearm injury to his right distal thigh. Following baseline investigations, imaging, and anaesthesia fitness, he underwent surgical exploration under general anaesthesia. A neuroma-in-continuity was found in the CPN, resected, and an end-to-end nerve repair was performed. Along with the neuroma-in-continuity, a bullet fragment was also removed. The neurological status remained unchanged postoperatively. Conclusion. Regardless of the cause of the lesion, patients should be urged to seek surgical therapy if there is no spontaneous recovery within four months after the CPN injury. Sharp injuries and knee dislocations have a better chance of recovery than crush injuries and gunshot wounds.
背景。腓总神经(CPN)损伤通常是常见的,但由于枪伤和运动预后不良而不常见。管理神经连续性瘤仍然具有挑战性,因为目前没有公认的标准来决定最有效的治疗过程或估计修复所需的时间。连续性神经瘤的治疗方案包括神经松解术、神经瘤切除术、端侧神经移植术和旁路移植术。案例演示。一个40岁的男人提出的发现完全右脚下降,由于8个月的火器伤害,他的右远端大腿。在基线检查、影像学检查和麻醉适应度检查后,患者在全身麻醉下进行了手术探查。在CPN中发现连续性神经瘤,切除,并进行端到端神经修复。除了神经连续性瘤,一块子弹碎片也被取出。术后神经系统状态保持不变。结论。无论病变的原因如何,如果患者在CPN损伤后四个月内没有自发恢复,应敦促患者寻求手术治疗。锐器伤和膝盖脱臼比挤压伤和枪伤有更好的恢复机会。
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引用次数: 0
Bilateral clinoidal Rosai Dorfman disease mimicking meningioma – a rare cause of bilateral blindness 模拟脑膜瘤的双侧斜面Rosai Dorfman病-一种罕见的双侧失明原因
Pub Date : 2023-03-15 DOI: 10.33962/roneuro-2023-012
Hrushikesh Kharosekar, Mayuresh Hinduja, Vernon Velho, Laxmikant Bhople
Rosai Dorfman disease is a self-limiting disease usually affecting the lymph nodes. Intracranial lesions are seen in less than 5% of cases. Isolated intracranial RDD without nodal involvement is rare, only 70 cases have been reported to date. Skull base lesions are seen in only 7 cases, petro clival RDD. Clionoidal lesions of RDD have not been reported in the literature, we report a rare case of bilateral Clionoidal lesions of RDD presenting with bilateral blindness in a young male.
罗赛多尔夫曼病是一种自限性疾病,通常影响淋巴结。颅内病变在不到5%的病例中可见。不累及淋巴结的孤立性颅内RDD是罕见的,迄今为止仅报道了70例。颅底病变仅7例见,斜坡性RDD。RDD的阴囊样体病变尚未在文献中报道,我们报告一例罕见的双侧阴囊样体病变的RDD表现为双侧失明的年轻男性。
{"title":"Bilateral clinoidal Rosai Dorfman disease mimicking meningioma – a rare cause of bilateral blindness","authors":"Hrushikesh Kharosekar, Mayuresh Hinduja, Vernon Velho, Laxmikant Bhople","doi":"10.33962/roneuro-2023-012","DOIUrl":"https://doi.org/10.33962/roneuro-2023-012","url":null,"abstract":"Rosai Dorfman disease is a self-limiting disease usually affecting the lymph nodes. Intracranial lesions are seen in less than 5% of cases. Isolated intracranial RDD without nodal involvement is rare, only 70 cases have been reported to date. Skull base lesions are seen in only 7 cases, petro clival RDD. Clionoidal lesions of RDD have not been reported in the literature, we report a rare case of bilateral Clionoidal lesions of RDD presenting with bilateral blindness in a young male.","PeriodicalId":30188,"journal":{"name":"Romanian Neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Romanian Neurosurgery
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