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Tranexamic acid in primary total knee arthroplasty: ideal route of administration 氨甲环酸在初次全膝关节置换术中的应用:理想的给药途径
Pub Date : 2019-12-01 DOI: 10.17489/biohun/2019/1/05
R. Gupta, R. Potalia, Pradyumna Krishna Majumdar, Parth Singh, A. Neogi
Background & Study Aims: Consensus is lacking regarding the optimal route and dose of administration of Tranexamic acid (TXA) so this study was conducted to compare the efficacy and safety of topical, oral and intravenous routes (iv) of TXA with routine hemostasis alone in patients undergoing primary total knee arthroplasty (TKA). Materials and methods: A prospective randomized trial was conducted in patients undergoing primary TKA. Patients were divided into four groups of 50 each; group 1 received intraarticular TXA, group 2 received oral TXA three hours before surgery, group 3 received IV TXA just before tourniquet release and group 4 did not receive TXA. Post-operative drain volume (PODV), fall in haemoglobin (Hb) level and the required amount of blood transfusion were evaluated. Results: PODV and drop in Hb level respectively were (158±90 ml and 1±0.5 g/dl) in group 1, (328±149 ml and 1.7±0.7 g/dl) in group 2, (311±151 ml and 2.1±1 g/dl) in group 3 and (589±115 ml and 3.2±1.2 g/dl) in group 4. The difference in drain volume between all groups was statistically significant except between groups 2 and 3. Transfusion requirements were significantly greater in group 4 (p< 0.001). Conclusions: Intra-articular, oral and IV TXA were observed to be safe strategies and more effective than tamponade effect alone to reduce drain volume and transfusion requirements after TKA. Additionally, intra-articular TXA was better than oral or IV TXA with respect to drain volume and post-op drop in Hb
背景与研究目的:对于氨甲环酸(TXA)的最佳给药途径和剂量缺乏共识,因此本研究旨在比较局部、口服和静脉给药途径(iv)与单纯常规止血在初次全膝关节置换术(TKA)患者中的疗效和安全性。材料和方法:对接受原发性TKA的患者进行前瞻性随机试验。患者被分为四组,每组50人;第1组在术前3小时接受关节内TXA,第2组在术后3小时接受口服TXA,3组在止血带释放前接受静脉注射TXA,4组不接受TXA。评估术后引流量(PODV)、血红蛋白(Hb)水平下降和所需输血量。结果:第一组PODV和Hb水平下降分别为(158±90 ml和1±0.5 g/dl),第二组为(328±149 ml和1.7±0.7 g/dl)、第三组为(311±151 ml和2.1±1 g/dl)和第四组为(589±115 ml和3.2±1.2 g/dl)。除第2组和第3组外,所有组之间的引流量差异具有统计学意义。第4组的输血需求显著增加(p<0.001)。结论:关节内、口服和静脉注射TXA是安全的策略,在减少TKA后的引流量和输血需求方面比单独的填塞效果更有效。此外,关节内TXA在引流量和术后Hb下降方面优于口服或静脉注射TXA
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引用次数: 0
Does pes planus influence standing balance in elementary school-age children? 扁足是否影响小学学龄儿童站立平衡?
Pub Date : 2019-12-01 DOI: 10.17489/biohun/2019/1/01
M. Takács, Gergely Nagymáté, Rita M. Kiss
Purpose: No any research in literature was found to investigate the effect of pes planus on standing balance in school-aged children. Any kind of change in the arches (height, flexibility) may increase the possibility of a change in standing balance. The aim of present study is to determine the influence of pes planus on the standing balance of school-aged children based on independent time-distance and frequency based parameters. Materials and Methods: Subjects included 177 children (105 neutral and 72 with pes planus). The parameters were determined from the motion of the centre of pressure (COP) on a platform equipped with pressure gauge sensors, on which the subjects were standing for 60 seconds with both feet and open eyes. Results: When comparing the neutral and pes planus groups, none of the 17 time-distance and frequency based parameters showed any significant difference (p≥0.169). Conclusion: The results show that pes planus does not affect significantly standing balance; the differences (however not significant) between the two groups showed a poorer postural control in school-aged children with pes planus. It may be compensated by the increased ML dimension of the base of support.
目的:文献中没有发现任何研究来调查扁平肌对学龄儿童站立平衡的影响。足弓的任何变化(高度、灵活性)都可能增加站立平衡变化的可能性。本研究的目的是基于独立的时间-距离和频率参数来确定扁平肌对学龄儿童站立平衡的影响。材料和方法:受试者包括177名儿童(105名中性和72名扁平型)。参数是根据压力中心(COP)在装有压力计传感器的平台上的运动确定的,受试者双脚睁开眼睛站在平台上60秒。结果:当比较中性组和扁平肌组时,17个基于时间距离和频率的参数均无显著差异(p≥0.169)。结论:结果表明扁平肌对站立平衡没有显著影响;两组之间的差异(但并不显著)表明学龄儿童扁平疱疹的姿势控制较差。它可以通过增加支撑基底的ML尺寸来补偿。
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引用次数: 2
Prospects in innovative manufacturing technology of UHMWPE for prostheses and comparison with medical grade UHMWPE 义肢用超高分子量聚乙烯创新制造技术展望及与医用级超高分子量聚乙烯的比较
Pub Date : 2019-12-01 DOI: 10.17489/biohun/2019/1/04
Ágnes Ureczki, K. Keszei
Due to its properties like high load-bearing capacity, biocompatibility, excellent abrasion resistance and strength, ultra-high molecular weight polyethylene (UHMWPE) is widely used as a bearing material in the field of joint prostheses. Currently, UHMWPE is produced by compression molding, ram extrusion or sintering, followed by post-processing techniques, such as milling or machining to finalize the prosthesis geometry and to achieve the final tolerances. With post-processing techniques we are wasting a high cost material, energy and time. In this paper, we collected manufacturing technologies that has have the potential to be used for creating prosthesis with one step production, minimalize material loss and with a view to providing customized manufacturing capabilities. We compared three technologies: (i) ram extrusion (currently used technology for joint prosthesis), (ii) FDM printing and (iii) injection molding. In addition to the feasibility, we focus on the investigation of mechanical properties. Three tests were performed on the manufactured specimens: hardness measurement, tensile test and scanning electron microscope (SEM) to compare the finished parts produced by the different processing technologies.
超高分子量聚乙烯(UHMWPE)由于其高承载能力、生物相容性、优异的耐磨性和强度等特性,被广泛应用于关节假体领域的承载材料。目前,超高分子量聚乙烯是通过压缩成型、冲压挤压或烧结来生产的,然后是后处理技术,如铣削或机械加工,以确定假体的几何形状并实现最终的公差。使用后处理技术,我们正在浪费高成本的材料,能源和时间。在本文中,我们收集了有潜力用于一步生产制造假肢的制造技术,最大限度地减少材料损失,并提供定制制造能力。我们比较了三种技术:(i)冲压(目前用于关节假体的技术),(ii) FDM打印和(iii)注射成型。除了可行性研究外,我们还重点研究了其力学性能。通过硬度测试、拉伸测试和扫描电子显微镜(SEM)测试,对不同加工工艺生产的成品件进行比较。
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引用次数: 2
The elements of fluid mechanics of bile flow through biliary drainage catheters 胆汁通过胆道引流管流动的流体力学原理
Pub Date : 2019-06-01 DOI: 10.17489/biohun/2019/1/03
Wenguang Li
Obstructive jaundice in the biliary tract can infect blood and result in mortality with a high rate. Percutaneous transhepatic biliary drainage (PTBD) with catheters is a useful solution discharging the obstructive jaundice. However, the elements of fluid mechanics showing clinical performance of a PTBD catheter have been documented little so far. In the article, empirical relationships between bile flow rate and pressure gradient in PTBD catheters were studied in terms of equivalent friction factor for the first time. Firstly, an equivalent friction factor in a catheter was raised and determined based on existing in vitro experimental data of bile flow through the catheters with different materials, various inner diameters and lengths under various pressure differences. Then, an empirical correlation of bile flow rate through a catheter was established based on pressure gradient, inner diameter and bile viscosity. The correlation was used to identify effects of catheter inner diameter and bile viscosity on the bile flow rate under the physiological bile pressure difference across obstructed common bile ducts. The feature of minor hydraulic losses in the catheters was clarified, too. The proposed equivalent friction factor was proportional to Reynolds number in a power of -0.654 in comparison with a power of -1 for the fully developed laminar flow in circular pipes. The bile flow rate through a catheter was proportional to inner diameter, kinematic viscosity, and pressure gradient in the powers of 3.2, -0.5 and 0.74, respectively. The minor hydraulic losses could be significant when Reynolds number was greater than 100.
胆道梗阻性黄疸可感染血液并导致高死亡率。带导管的经皮肝穿刺胆道引流(PTBD)是一种有效的解决梗阻性黄疸的方法。然而,迄今为止,显示PTBD导管临床性能的流体力学元素很少被记录在案。本文首次从等效摩擦系数的角度研究了PTBD导管中胆汁流速与压力梯度之间的经验关系。首先,根据现有的不同材料、不同内径和长度的导管在不同压差下胆汁流动的体外实验数据,提出并确定了导管中的等效摩擦系数。然后,根据压力梯度、内径和胆汁粘度建立了通过导管的胆汁流速的经验相关性。该相关性用于确定在生理胆汁压差下,导管内径和胆汁粘度对阻塞的总胆管胆汁流速的影响。导管中轻微液压损失的特征也得到了澄清。所提出的等效摩擦系数与雷诺数成正比,幂为-0.654,而圆形管道中完全发展层流的幂为-1。通过导管的胆汁流速与内径、运动粘度和压力梯度成正比,其幂分别为3.2、-0.5和0.74。当雷诺数大于100时,较小的水力损失可能是显著的。
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引用次数: 0
Vezércikk 主要文章
Pub Date : 2019-01-01 DOI: 10.17489/biohun/2019/1/0h
Rita Kiss M.
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引用次数: 0
Acute effect of active elongating technique on the morphological characteristics of the spine 主动伸长技术对脊柱形态特征的急性影响
Pub Date : 2018-11-26 DOI: 10.17489/2018/2/05
Judith Kondor, Anna Széll, J. Tihanyi
Our kinesiologist focus is on the active elongation of spine. This very simple movement like active spine elongation makes measurable different in sagittal curves, that would be detect-ed with Spinal Mouse electromechanical device. It detects the datas about gait parameters from the cervical 7 to sacral 1 vertebra’s processus spinosus about every movement segment in sagittal plane and spine length too. We had tested that on 27 persons: (n =13) men and (n=14) women, (n=9) of them were competent in elongation. The purpose of this study was to verify the change of spine length withal thoracic kyphosis and lumbar lordosis during active elongation in the vertebral column and conclude deep vertebral stabilizer muscle-func-tion, regarding the voluntary contraction of multifidii muscles. Furthermore to improve therapeutic approaches in the spinal control of the biomechanical centre, called lumbopelvic segment. The ideal gait of human creates a big debate in the physiotherapeutic or the movement professions. Although the physiological posture should be given the basic means of the trunk-stabilization exercises. Our results prove significant effect of elongation on the spine. It was success to verify the rel-evancy (p = 0,001) of elongation-practised i.e. non-start person compared to start ones (they had used active spine elongation first time in their life) in the length of spine. Significant augmentation (p = 0,02) was given between normal own spine length and elongated length. Significant decrease (p = 0,001) was measured between normal/own thoracic kyphosis and the elongated kyphosys, but didn’t shown significant difference (p = 0,24) in the sagittal curve of lumbar spine. But we could experience clear reduction of lordosis in both group (p = 0,917) and segmentally as well. We can deduce from lumbar orientation and spinal control effect and even that this Spinal Mouse can’t be the right device to prove the real meaning of elongation in the lumbar spine, because of its neuromuscular (muscle tone) and biomechanical nature (degree of freedom).
我们的运动机能学家专注于脊椎的主动伸展。这种非常简单的运动,如主动脊柱伸长,可以测量矢状曲线的不同,这将通过脊髓鼠标机电设备检测到。它还检测了从颈7椎到骶1椎棘突在矢状面上每个运动段的步态参数和脊柱长度。我们在27个人身上进行了测试:(n=13)男性和(n=14)女性,其中(n=9)有伸长能力。本研究的目的是验证脊柱主动伸长过程中脊柱长度随胸椎后凸和腰椎前凸的变化,并得出深层脊椎稳定肌的功能,即多鳍肌的自主收缩。此外,为了改进脊柱生物力学中心的治疗方法,称为腰叶段。人类的理想步态在物理治疗或运动专业中引起了很大的争论。虽然生理姿势应该给予躯干稳定练习的基本手段。我们的研究结果证明了伸长对脊柱的显著影响。成功地验证了脊柱长度方面练习的伸长率的相关性(p=0.001),即非初学者与初学者(他们一生中第一次使用主动脊柱伸长率)相比。正常自身脊柱长度和细长长度之间存在显著的增加(p=0.02)。正常/自身胸部后凸和细长后凸之间的测量值显著降低(p=0.001),但腰椎矢状曲线没有显示出显著差异(p=0.024)。但我们在两组中都可以看到明显的前凸缩小(p=0917),在节段上也是如此。我们可以从腰椎方向和脊椎控制效果推断,甚至这种脊髓鼠也不可能是证明腰椎伸长真正意义的正确装置,因为它具有神经肌肉(肌肉张力)和生物力学性质(自由度)。
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引用次数: 0
Realization of material laws in accordance with the bone’s material properties carried out by additive manufacturing technologies 通过增材制造技术实现符合骨骼材料特性的材料规律
Pub Date : 2018-11-26 DOI: 10.17489/2018/2/11
P. Ficzere, L. Borbás, G. Falk
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引用次数: 0
Stiffening effect of human tendons during strain controlled fatigue loading 应变控制疲劳加载过程中人体肌腱的加固作用
Pub Date : 2018-11-26 DOI: 10.17489/2018/2/09
G. Szebényi, D. Faragó, R. Kiss, K. Pap
The goals of our study were to evaluate the biomechanical differences between five tendons and the changes in biomechanical properties caused by low cycle fatigue loading. Achilles, quadriceps, semitendinosus + gracilis (STG), tibialis anterior (TA) and the peroneus longus (PL) were harvested from 8 donors. The grafts were removed and placed in a radio-cryopro-tectant solution and slowly cooled and stored at -78 °C. The load was defined as a sinusoid function, the starting values are assigned to a peak load of 250 N and a minimum load of 0 N. Data was recorded in the 2th, 4th, 8th, 16th, 32nd, 64th, 128th, 256th, 515th and 1000th cycle. In the given cycles the whole measured waveform was registered. Young modulus of elasticity was calculated. To compare the biomechanical behavior of the different tendons the Young’s modulus values were evaluated in the 64th, 128th, 256th, 512th and 1000th cycles. While in case of PL and STG tendons the change is apperantly linear in the investigated range, in case of the Achilles, quadriceps and TA tendons there is a region where a significant change in modulus occurs.
我们的研究目的是评估五种肌腱之间的生物力学差异以及低周疲劳载荷引起的生物力学性能变化。取8例供体跟腱、股四头肌、半腱肌+股股肌(STG)、胫骨前肌(TA)和腓骨长肌(PL)。将移植物取出,置于放射性防冻剂溶液中,缓慢冷却并保存在-78°C。将负荷定义为正弦函数,峰值荷载为250 N,最小荷载为0 N,起始值分别为第2、4、8、16、32、64、128、256、515和1000个周期记录数据。在给定的周期内,整个测量波形被记录下来。计算杨氏弹性模量。为了比较不同肌腱的生物力学行为,在第64、128、256、512和1000次循环时评估杨氏模量值。在PL和STG肌腱的情况下,在研究范围内的变化明显是线性的,而在跟腱、股四头肌和TA肌腱的情况下,有一个区域的模量发生了显著变化。
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引用次数: 0
Measure the effectiveness of lymphoedema treatment by gait analysis 步态分析法测定淋巴水肿治疗效果
Pub Date : 2018-11-26 DOI: 10.17489/2018/2/01
K. Hampel, Zsófia Pálya, R. Kiss
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引用次数: 0
Examining equilibrium role of visual and vestibular systems in the case of dancers and women without a dance experience 在舞者和没有舞蹈经验的女性的情况下,检查视觉和前庭系统的平衡作用
Pub Date : 2018-11-26 DOI: 10.17489/2018/2/04
Fanni Dulházi, B. Kopper, J. Tihanyi
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引用次数: 0
期刊
Biomechanica Hungarica
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