B. Dvorštiaková, V. Jakušová, R. Ulbrichtová, H. Hudeckova
Abstract Introduction: Recent worldwide researches dealing with artificial sources of ultraviolet radiation have noticed an increased incidence of skin cancer, conjunctivitis, or decreased immunity. Melanoma is the most serious disease that may be caused by sunbeds. Goal: The main goal of the study was to coherently process public health issues of sunbeds and find out a level of information and attitude of adult population in the Turiec Region. Material and method: In the II. half of 2016 we carried out a questionnaire survey focused on information and attitude of adult population towards sunbeds and their negative effect on humans. The total sample consisted of 121 adult participants (74 females and 47 males) from the Turiec Region. Results: The age range of participants was 36 ± 6.5 years and the age range of sunbed users was 31 ± 4.8 (x ± SD). From the total sample of 121 participants 34 (28.1%) visit sunbed and 87 (71.9%) do not. Sunbeds are visited more by women (85.3%), but men (p 0.05) take longer sunbaths than women. Women (p 0.05) were more informed about their phototype than men. Only 51 (42.2%) of participants were aware of their skin phototype and better informed were participants with higher education. From the survey only 13 (38.2%) participants used the combination of protective sunglasses and sunscreens. Conclusion: The results show that visitors of sunbeds had a higher level of information than non-visitors. A negative aspect is that the participants didn’t know the phototype of their skin and didn’t use all protective aids. Most participants said that information on sunbed are inadequate. From the public health view it is very important to focus on prevention, spread information about diseases influenced by artificial source of UV radiation, and educate the population.
{"title":"Sunbeds use – tanning pattern and UV protective behaviour of adults of the Turiec Region","authors":"B. Dvorštiaková, V. Jakušová, R. Ulbrichtová, H. Hudeckova","doi":"10.2478/acm-2018-0008","DOIUrl":"https://doi.org/10.2478/acm-2018-0008","url":null,"abstract":"Abstract Introduction: Recent worldwide researches dealing with artificial sources of ultraviolet radiation have noticed an increased incidence of skin cancer, conjunctivitis, or decreased immunity. Melanoma is the most serious disease that may be caused by sunbeds. Goal: The main goal of the study was to coherently process public health issues of sunbeds and find out a level of information and attitude of adult population in the Turiec Region. Material and method: In the II. half of 2016 we carried out a questionnaire survey focused on information and attitude of adult population towards sunbeds and their negative effect on humans. The total sample consisted of 121 adult participants (74 females and 47 males) from the Turiec Region. Results: The age range of participants was 36 ± 6.5 years and the age range of sunbed users was 31 ± 4.8 (x ± SD). From the total sample of 121 participants 34 (28.1%) visit sunbed and 87 (71.9%) do not. Sunbeds are visited more by women (85.3%), but men (p 0.05) take longer sunbaths than women. Women (p 0.05) were more informed about their phototype than men. Only 51 (42.2%) of participants were aware of their skin phototype and better informed were participants with higher education. From the survey only 13 (38.2%) participants used the combination of protective sunglasses and sunscreens. Conclusion: The results show that visitors of sunbeds had a higher level of information than non-visitors. A negative aspect is that the participants didn’t know the phototype of their skin and didn’t use all protective aids. Most participants said that information on sunbed are inadequate. From the public health view it is very important to focus on prevention, spread information about diseases influenced by artificial source of UV radiation, and educate the population.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"13 - 19"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42481828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Škorňová, M. Samoš, R. Šimonová, J. Žolková, L. Stančiaková, Ľ. Vádelová, T. Bolek, L. Urban, F. Kovář, J. Staško, P. Galajda, P. Kubisz, M. Mokáň
Abstract Objectives: Several studies have questioned the need for platelet function testing in patients treated with new ADP receptor blockers (ADPRB). The aim of this study was to evaluate the prevalence of high on-treatment platelet reactivity (HTPR) among acute ST-elevation myocardial infarction (STEMI) patients treated with newer ADPRB. Methods: A prospective study enrolling 44 acute previously ADPRB naive STEMI patients (31 men, 13 women) undergoing primary percutaneous coronary intervention (pPCI) was performed. Among the studied population 23 patients received prasugrel and 21 patients received ticagrelor. Antiplatelet response was tested with light transmission aggregometry (LTA) and vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) flow cytometry assay. Samples were taken prior to coronary angiography (sample 1) and on the day after this procedure (sample 2). Results: The mean platelet aggregation after induction with ADP was 51.7 ± 24.8% in sample 1 and 25.3 ± 20.1% in sample 2. An examination of VASP-P showed a mean platelet reactivity index of 56.8 ± 25.7% in sample 1 and 23.8 ± 23.1% in sample 2, respectively. The study identified 11.4% of patients in sample 2 as ADP receptor blocker non-responders. No significant differences were found between prasugrel-treated to ticagrelor-treated patients. Conclusions: This pilot study demonstrated HTPR among acute STEMI patients treated with newer ADPRB.
{"title":"On-treatment platelet reactivity in the era of new ADP receptor blockers: data from a real-world clinical practice","authors":"I. Škorňová, M. Samoš, R. Šimonová, J. Žolková, L. Stančiaková, Ľ. Vádelová, T. Bolek, L. Urban, F. Kovář, J. Staško, P. Galajda, P. Kubisz, M. Mokáň","doi":"10.2478/acm-2018-0011","DOIUrl":"https://doi.org/10.2478/acm-2018-0011","url":null,"abstract":"Abstract Objectives: Several studies have questioned the need for platelet function testing in patients treated with new ADP receptor blockers (ADPRB). The aim of this study was to evaluate the prevalence of high on-treatment platelet reactivity (HTPR) among acute ST-elevation myocardial infarction (STEMI) patients treated with newer ADPRB. Methods: A prospective study enrolling 44 acute previously ADPRB naive STEMI patients (31 men, 13 women) undergoing primary percutaneous coronary intervention (pPCI) was performed. Among the studied population 23 patients received prasugrel and 21 patients received ticagrelor. Antiplatelet response was tested with light transmission aggregometry (LTA) and vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) flow cytometry assay. Samples were taken prior to coronary angiography (sample 1) and on the day after this procedure (sample 2). Results: The mean platelet aggregation after induction with ADP was 51.7 ± 24.8% in sample 1 and 25.3 ± 20.1% in sample 2. An examination of VASP-P showed a mean platelet reactivity index of 56.8 ± 25.7% in sample 1 and 23.8 ± 23.1% in sample 2, respectively. The study identified 11.4% of patients in sample 2 as ADP receptor blocker non-responders. No significant differences were found between prasugrel-treated to ticagrelor-treated patients. Conclusions: This pilot study demonstrated HTPR among acute STEMI patients treated with newer ADPRB.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"34 - 39"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44746775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Míšek, T. Lauková, M. Kohan, M. Veternik, V. Jakušová, J. Jakuš
Abstract In recent years there has been an increase in development of electromagnetic (EM) technology in the telecommunication industry, resulting in an increase in human non-ionizing exposure. This fact has initiated a number of scientific studies on possible health effects of EM fields on human organism. Totally four representative microenvironments were investigated for RF EM fields distribution, namely: city center, residential area, rural area, and extra-village area. Each microenvironment was measured 20 times in accordance with the International Commission for Non-Ionizing Radiation Protection (ICNIRP) guidelines. The extra-village measurements were taken as the base values that reflect the E-field intensities with the lowest amplitudes. The statistical analysis revealed notable statistical significance (p < 0.001) in almost all measured frequency bands except the Wi-Fi where the p-values were less than 0.05 for the city center and residential area but not significant for rural area. The highest total E-field intensity was measured in the residential area (approximately 1.85 V/m). All measured values were below the legal limits of the Slovak Republic and ICNIRP safety guidelines. However, the ICNIRP safety limits were written in 1998 considering only the thermal effects of RF radiation. They were updated in 2009 without any changes in the limits and still recommend 27.5 – 61 V/m (2 – 10 W/m2) for the RF frequency band of 400–2,000 MHz. The BioInitiative Report of 2012 established the scientific benchmark for possible health risks as 30–60 μW/m2 (approximately 0.1 – 0.15 V/m). Thus, all measured values were above the scientifically derived limits.
{"title":"Measurement of Low-level radiofrequency electromagnetic fields in the human environment","authors":"J. Míšek, T. Lauková, M. Kohan, M. Veternik, V. Jakušová, J. Jakuš","doi":"10.2478/acm-2018-0010","DOIUrl":"https://doi.org/10.2478/acm-2018-0010","url":null,"abstract":"Abstract In recent years there has been an increase in development of electromagnetic (EM) technology in the telecommunication industry, resulting in an increase in human non-ionizing exposure. This fact has initiated a number of scientific studies on possible health effects of EM fields on human organism. Totally four representative microenvironments were investigated for RF EM fields distribution, namely: city center, residential area, rural area, and extra-village area. Each microenvironment was measured 20 times in accordance with the International Commission for Non-Ionizing Radiation Protection (ICNIRP) guidelines. The extra-village measurements were taken as the base values that reflect the E-field intensities with the lowest amplitudes. The statistical analysis revealed notable statistical significance (p < 0.001) in almost all measured frequency bands except the Wi-Fi where the p-values were less than 0.05 for the city center and residential area but not significant for rural area. The highest total E-field intensity was measured in the residential area (approximately 1.85 V/m). All measured values were below the legal limits of the Slovak Republic and ICNIRP safety guidelines. However, the ICNIRP safety limits were written in 1998 considering only the thermal effects of RF radiation. They were updated in 2009 without any changes in the limits and still recommend 27.5 – 61 V/m (2 – 10 W/m2) for the RF frequency band of 400–2,000 MHz. The BioInitiative Report of 2012 established the scientific benchmark for possible health risks as 30–60 μW/m2 (approximately 0.1 – 0.15 V/m). Thus, all measured values were above the scientifically derived limits.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"27 - 33"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44177029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Novak, I. Mazakova, V. Sadloňová, T. Červeňová, H. Hudeckova
Abstract Introduction: Decrease of nonspecific imunity in patients and the treatment with broad spectrum antibiotics form appropriate conditions for the appearance of medically severe Clostridium difficile infection (CDI) - enterocolitis that can have the characteristics of community or hospital acquired infection (HAI). The aim of our work is to identify the trend of their incidence in Slovakia and to define the risk groups according to age and department of hospitalisation. Material and Methods: Retrospective analysis and comparison of the appearance of CDI was performed within the groups of patients hospitalised in health care institutions in the SR and those in the district of Martin during the period of years 2010 to 2017. The data of reported cases were taken from the Epidemiological information system of the Slovak Republic (EPIS SR), the source of demografic data was the National Center of Health Information. Resuts: Analysis shows an important increase of incidence of CDI during years 2010 to 2017. Diseases had predominantly health care associated – nosocomial – character targeting mostly older patients (65+ - 24/10 000 in the Slovak Republic and 62/10,000 in the county of Martin) and less infants (7/10,000 and 11/10,000 repectively). Conclusion: The results of our analyses are consistent with literature data about CDI enterocolitis and show their serious health and social impact in our society.
{"title":"Appearance of Clostridium difficile infections in health care institutions in Slovakia and in the district of martin","authors":"M. Novak, I. Mazakova, V. Sadloňová, T. Červeňová, H. Hudeckova","doi":"10.2478/acm-2018-0007","DOIUrl":"https://doi.org/10.2478/acm-2018-0007","url":null,"abstract":"Abstract Introduction: Decrease of nonspecific imunity in patients and the treatment with broad spectrum antibiotics form appropriate conditions for the appearance of medically severe Clostridium difficile infection (CDI) - enterocolitis that can have the characteristics of community or hospital acquired infection (HAI). The aim of our work is to identify the trend of their incidence in Slovakia and to define the risk groups according to age and department of hospitalisation. Material and Methods: Retrospective analysis and comparison of the appearance of CDI was performed within the groups of patients hospitalised in health care institutions in the SR and those in the district of Martin during the period of years 2010 to 2017. The data of reported cases were taken from the Epidemiological information system of the Slovak Republic (EPIS SR), the source of demografic data was the National Center of Health Information. Resuts: Analysis shows an important increase of incidence of CDI during years 2010 to 2017. Diseases had predominantly health care associated – nosocomial – character targeting mostly older patients (65+ - 24/10 000 in the Slovak Republic and 62/10,000 in the county of Martin) and less infants (7/10,000 and 11/10,000 repectively). Conclusion: The results of our analyses are consistent with literature data about CDI enterocolitis and show their serious health and social impact in our society.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"12 - 5"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48358590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Ulbrichtová, V. Jakušová, B. Dvorštiaková, H. Hudeckova
Abstract Introduction: The automotive industry represents the most important industrial sector in Slovakia. Overall, there are more than 200,000 people employed in this sector. The work in automotive industry is monotonous and repetitive with excessive number of movements of upper extremities. Methods: In this retrospective study the development of specific occupational diseases in Slovak automotive industry was analyzed. The frequency and occurrence of major occupational diseases in the period from 1987 to 2017 was analyzed, including major causes and factors which influence the rise and development of these occupational diseases (the long-term excessive unilateral load of upper extremities, noise-related diseases). Data on occupational diseases cases were retrieved from the National Registry of occupational diseases. Results: Diseases due to the long-term excessive unilateral load of upper extremities have been at the first place in the order of all admitted occupational diseases in the Slovak Republic since 1997. The total number of notified occupational diseases in respective years shows a declining trend whereas the number of diseases due to the long-term excessive unilateral load of upper extremities as well as evaluations of suspected occupational diseases has the rising trend. Between 1987 and 2017 a total of 20,370 new cases were recorded, of which 4,707 (23.10%) were diseases due to the long-term excessive unilateral load of upper extremities and 2,150 (10.55%) were noise-related occupational diseases. Conclusions: The automotive industry offers a lot of job opportunities. On the other hand, it is characterized by a type of working activity that poses a considerable risk to employees.
{"title":"Possible impact of automotive industry on the health of working population","authors":"R. Ulbrichtová, V. Jakušová, B. Dvorštiaková, H. Hudeckova","doi":"10.2478/acm-2018-0009","DOIUrl":"https://doi.org/10.2478/acm-2018-0009","url":null,"abstract":"Abstract Introduction: The automotive industry represents the most important industrial sector in Slovakia. Overall, there are more than 200,000 people employed in this sector. The work in automotive industry is monotonous and repetitive with excessive number of movements of upper extremities. Methods: In this retrospective study the development of specific occupational diseases in Slovak automotive industry was analyzed. The frequency and occurrence of major occupational diseases in the period from 1987 to 2017 was analyzed, including major causes and factors which influence the rise and development of these occupational diseases (the long-term excessive unilateral load of upper extremities, noise-related diseases). Data on occupational diseases cases were retrieved from the National Registry of occupational diseases. Results: Diseases due to the long-term excessive unilateral load of upper extremities have been at the first place in the order of all admitted occupational diseases in the Slovak Republic since 1997. The total number of notified occupational diseases in respective years shows a declining trend whereas the number of diseases due to the long-term excessive unilateral load of upper extremities as well as evaluations of suspected occupational diseases has the rising trend. Between 1987 and 2017 a total of 20,370 new cases were recorded, of which 4,707 (23.10%) were diseases due to the long-term excessive unilateral load of upper extremities and 2,150 (10.55%) were noise-related occupational diseases. Conclusions: The automotive industry offers a lot of job opportunities. On the other hand, it is characterized by a type of working activity that poses a considerable risk to employees.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"20 - 26"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47452855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Phototherapy represents the most common therapeutic intervention at neonatology departments in the first days of life. The beneficial effects of light on the decrease of the serum bilirubin level were first described by Cremer et al. in 1950’s (1). Since then phototherapy has been successfully used to treat severe hyperbilirubinaemia and has almost completely replaced exchange transfusion. Phototherapy is a relatively non-invasive method. However, along with decreasing bilirubin level, it can also influence some other functions: perfusion of organs, predominantly skin; peripheral vascular resistance; distribution of blood flow; heart activity and, thus, also systemic blood pressure along with breathing. A side component of applied light is a certain amount of heat which warms the body surface up and, therefore, the risk of exogenous overheating and increased water loss through the skin arise. Maternal-infant separation, modification of calcium homeostasis, disturbed circadian rhythm, or changes of the hemodynamics of various organ systems are only a few of the undesired effects which prove phototherapy not to be a treatment without any side effects. Careful indication of phototherapy is essential, particularly in premature infants.
{"title":"Phototherapy and its effect on some physiological functions in newborns","authors":"L. Nandrážiová, Katarina Matasova, R. Gumulak","doi":"10.2478/acm-2018-0001","DOIUrl":"https://doi.org/10.2478/acm-2018-0001","url":null,"abstract":"Abstract Phototherapy represents the most common therapeutic intervention at neonatology departments in the first days of life. The beneficial effects of light on the decrease of the serum bilirubin level were first described by Cremer et al. in 1950’s (1). Since then phototherapy has been successfully used to treat severe hyperbilirubinaemia and has almost completely replaced exchange transfusion. Phototherapy is a relatively non-invasive method. However, along with decreasing bilirubin level, it can also influence some other functions: perfusion of organs, predominantly skin; peripheral vascular resistance; distribution of blood flow; heart activity and, thus, also systemic blood pressure along with breathing. A side component of applied light is a certain amount of heat which warms the body surface up and, therefore, the risk of exogenous overheating and increased water loss through the skin arise. Maternal-infant separation, modification of calcium homeostasis, disturbed circadian rhythm, or changes of the hemodynamics of various organ systems are only a few of the undesired effects which prove phototherapy not to be a treatment without any side effects. Careful indication of phototherapy is essential, particularly in premature infants.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"13 - 5"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46329742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Non-syndromic 46,XY DSD (disorders of sex development) represent a phenotypically diversiform group of disorders. We focus on the association between gene variants and the most frequent types of non-syndromic 46,XY DSD, options of molecular genetic testing which has surely taken its place in diagnostics of DSD in the past couple of years. We emphasize the need of molecular genetic testing in individuals with non-syndromic 46,XY DSD in Slovak Republic.
{"title":"Non-Syndromic 46,XY Disorders of Sex Development","authors":"J. Gécz, J. Breza, P. Bánovčin","doi":"10.2478/acm-2018-0005","DOIUrl":"https://doi.org/10.2478/acm-2018-0005","url":null,"abstract":"Abstract Non-syndromic 46,XY DSD (disorders of sex development) represent a phenotypically diversiform group of disorders. We focus on the association between gene variants and the most frequent types of non-syndromic 46,XY DSD, options of molecular genetic testing which has surely taken its place in diagnostics of DSD in the past couple of years. We emphasize the need of molecular genetic testing in individuals with non-syndromic 46,XY DSD in Slovak Republic.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"35 - 41"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/acm-2018-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46836441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Kalmarova, E. Kurča, V. Nosáľ, J. Dluhá, J. Ballova, J. Sokol, I. Škorňová, J. Staško, J. Žolková, Ľ. Vádelová
Abstract Aims: The aim of this study was to asses the platelet activation in the acute phase of ischemic stroke and transient ischemic attack (TIA) by defining p-selectin (CD62) expression by flow cytometry in vivo – without stimulation with agonists. We also studied whether antiplatelet therapy supresses the levels of baseline p-selectin expression and verified if there is a correlation between platelet CD62 expression and the type of ischemic stroke. Methods: We determined the expression of platelet surface p-selectin using whole-blood flow cytometry within the first 48-hours after onset of cerebral symptoms in patients with atherothrombotic and lacunar ischemic stroke and in healthy volunteers. We studied the realationship between antiplatelet medication and the type of ischemic stroke to baseline p-selectin expression. Results: Patients with acute cerebral ischemia have an excess of circulating platelets that express p-selectin, compared to healthy volunteers. The difference between average p-selectin expression in the group of healthy volunteers and the group of patients with stroke was statistically significant (p-value < 0,000001). Patients with stroke without antiplatelet medication showed a higher p-selectin expression than patients with antiplatelet medication (ASA, CLP, or ASA and CLP), hovewer, the difference was not statistically significant. There is no relationship between CD62 expression and the type of stroke. Conclusions: We can conclude that p-selectin is a highly sensitive blood biomarker of increased platelet activation. Antiplatelet therapy suppresses baseline p-selectin expression only minimally, insignificantly according to our results.
{"title":"Measurement of platelet p-selectin expression by flow cytometry in patients with acute ischemic stroke","authors":"K. Kalmarova, E. Kurča, V. Nosáľ, J. Dluhá, J. Ballova, J. Sokol, I. Škorňová, J. Staško, J. Žolková, Ľ. Vádelová","doi":"10.2478/acm-2018-0002","DOIUrl":"https://doi.org/10.2478/acm-2018-0002","url":null,"abstract":"Abstract Aims: The aim of this study was to asses the platelet activation in the acute phase of ischemic stroke and transient ischemic attack (TIA) by defining p-selectin (CD62) expression by flow cytometry in vivo – without stimulation with agonists. We also studied whether antiplatelet therapy supresses the levels of baseline p-selectin expression and verified if there is a correlation between platelet CD62 expression and the type of ischemic stroke. Methods: We determined the expression of platelet surface p-selectin using whole-blood flow cytometry within the first 48-hours after onset of cerebral symptoms in patients with atherothrombotic and lacunar ischemic stroke and in healthy volunteers. We studied the realationship between antiplatelet medication and the type of ischemic stroke to baseline p-selectin expression. Results: Patients with acute cerebral ischemia have an excess of circulating platelets that express p-selectin, compared to healthy volunteers. The difference between average p-selectin expression in the group of healthy volunteers and the group of patients with stroke was statistically significant (p-value < 0,000001). Patients with stroke without antiplatelet medication showed a higher p-selectin expression than patients with antiplatelet medication (ASA, CLP, or ASA and CLP), hovewer, the difference was not statistically significant. There is no relationship between CD62 expression and the type of stroke. Conclusions: We can conclude that p-selectin is a highly sensitive blood biomarker of increased platelet activation. Antiplatelet therapy suppresses baseline p-selectin expression only minimally, insignificantly according to our results.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"14 - 20"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43764453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Madelung’s disease also called benign symmetric lipomatosis is a rare disorder of unknown etiology. The disease affects almost exclusively middle-aged men with a history of multi-year alcohol abuse. The major symptom is presence of non-encapsulated benign fat masses, especially in the area of the head and neck. Limited head and neck movement, dysphagia, and dyspnea may appear as well. The diagnosis is clinical and is supported by imaging methods, often elevated hepatic enzymes in blood serum, and histological examination with finding of mature adipose tissue without signs of proliferation. Therapeutic methods involve liposuction or excision which is a method of choice nowadays. In this article the authors review current knowledge, research state, and present five cases of the Madelung’s disease occurring within the last 10 years at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Martin, Slovakia.
{"title":"Madelung’s disease: case series and literature review","authors":"H. Pedan, E. Behanova, V. Calkovsky, A. Hajtman","doi":"10.2478/acm-2018-0004","DOIUrl":"https://doi.org/10.2478/acm-2018-0004","url":null,"abstract":"Abstract Madelung’s disease also called benign symmetric lipomatosis is a rare disorder of unknown etiology. The disease affects almost exclusively middle-aged men with a history of multi-year alcohol abuse. The major symptom is presence of non-encapsulated benign fat masses, especially in the area of the head and neck. Limited head and neck movement, dysphagia, and dyspnea may appear as well. The diagnosis is clinical and is supported by imaging methods, often elevated hepatic enzymes in blood serum, and histological examination with finding of mature adipose tissue without signs of proliferation. Therapeutic methods involve liposuction or excision which is a method of choice nowadays. In this article the authors review current knowledge, research state, and present five cases of the Madelung’s disease occurring within the last 10 years at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Martin, Slovakia.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"30 - 34"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49472029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Facial cleft malformations belong to the most common problems of the congenital facial anomalies. At the Clinic of Plastic, Aestetic and Reconstructive Surgery at the Faculty Hospital in Banská Bystrica we have been performing primary cleft lip repairs during the first week of life of a newborn since 1995. During this life period the fetal healing still persists. Modern anesthetic techniques have considerably reduced respiratory complications after the lip closure. The adequate postoperative sedation together with monitoring of the pacient remarkably reduces the occurrence of wound dehiscence. The advantages of the neonatal cleft lip repair are the scarless healing, no negative effect on the growth of the middle thirt of the face, as well as the pschychosocial effect on the family and the fact that the ortodontic aparat has not been needed.
{"title":"Primary Repair of Cleft Lip and Nose in the Neonatal Period","authors":"Strenacikova S Valentova, R. Malina","doi":"10.2478/acm-2018-0006","DOIUrl":"https://doi.org/10.2478/acm-2018-0006","url":null,"abstract":"Abstract Facial cleft malformations belong to the most common problems of the congenital facial anomalies. At the Clinic of Plastic, Aestetic and Reconstructive Surgery at the Faculty Hospital in Banská Bystrica we have been performing primary cleft lip repairs during the first week of life of a newborn since 1995. During this life period the fetal healing still persists. Modern anesthetic techniques have considerably reduced respiratory complications after the lip closure. The adequate postoperative sedation together with monitoring of the pacient remarkably reduces the occurrence of wound dehiscence. The advantages of the neonatal cleft lip repair are the scarless healing, no negative effect on the growth of the middle thirt of the face, as well as the pschychosocial effect on the family and the fact that the ortodontic aparat has not been needed.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"18 1","pages":"42 - 48"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42601811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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