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Life in the Age of the Covid19 Pandemic: Integrative Medicine in Prevention and Treatment 2019冠状病毒病大流行时代的生活:中西医结合防治
Pub Date : 2023-01-05 DOI: 10.33140/jnh.08.01.05
Be prepared for the coronavirus With the COVID-19 pandemic, humanity is facing a global health threat for which no specific therapy has yet been scientifically determined.
随着2019冠状病毒病(COVID-19)的大流行,人类正面临着一场全球性的健康威胁,而目前还没有科学确定具体的治疗方法。
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引用次数: 0
Reference Values of Myocardial T1 Relaxation Times in Healthy Latin American Patients 拉丁美洲健康患者心肌T1舒张时间的参考值
Pub Date : 2023-01-05 DOI: 10.33140/jnh.08.01.08
Theoretical framework. Cardiac magnetic resonance imaging (CMR) is an invaluable tool for diagnosis and risk stratification in a broad spectrum of cardiac diseases. Magnetic resonance imaging techniques are increasingly complemented by mapping sequences that allow quantitative assessment of myocardial tissue with measurement of absolute relaxation times T1, T2, and T2*. The clinical utilities are diverse, among which is the quantification of edema and/or fibrosis through the estimation of the extracellular volume fraction calculated from pre-contrast, post-contrast and hematocrit T1 relaxation times. There are multiple ways to obtain T1 mapping images, among which the modified look-locker inversion recovery technique (MOLLI) stands out. However, different manufacturers have designed various methods of obtaining them with slight variability between the equipment. Aim To determine the reference values of myocardial T1 relaxation times in our population to justify their clinical interpretation in the tissue evaluation of different cardiovascular diseases. Material and method. Type of study: prospective observational and single center. Field intensity/sequence A short CMR protocol was performed in a 1.5 T resonator, using the MOLLI technique, in T1 mapping. Evaluation Global and segmental T1 values were quantified, using the American Heart Association (AHA) model, for the entire left ventricle, in three short-axis slices (basal, mid, and apical). The post processing and analysis of the data with the commercialized software, Cvi42. Results The mean global myocardial T1 value was 1069.41 ms with a SD of 38.73 msec. Among the age groups, the <34-year-old group had the lowest global T1 values (1057 SD 33 msec), and the 35-year-old group -44 years obtained the highest values (1100 SD 50 msec), so no relationship was found between the linear increase in age and the variability of relaxation times. Between both sexes, men had lower global T1 values than women (1049 vs 1086). conclusions Native T1 ranges can serve as a basis for the quantitative characterization of the myocardium in the context of focal or diffuse diseases, in patients with infarcts, storage diseases, and inflammatory diseases. We are getting closer to standardizing the clinical use of these techniques by CMR. In conclusion, this analysis allows us to take another step to establish their use in the Latin American population.
理论框架。心脏磁共振成像(CMR)是广泛的心脏疾病诊断和风险分层的宝贵工具。磁共振成像技术越来越多地与测绘序列相辅相成,可以通过测量绝对松弛时间T1、T2和T2*来定量评估心肌组织。临床应用是多种多样的,其中包括通过估计对比前、对比后和红细胞压积T1松弛时间计算的细胞外体积分数来量化水肿和/或纤维化。获得T1映射图像的方法有很多种,其中改进的looklocker反演恢复技术(MOLLI)最为突出。然而,不同的制造商设计了各种方法来获得它们,设备之间有轻微的差异。目的确定人群心肌T1弛豫时间的参考值,以证明其在不同心血管疾病组织评价中的临床意义。材料和方法。研究类型:前瞻性观察和单中心。在T1映射中,使用MOLLI技术在1.5 T谐振器中进行了短CMR协议。使用美国心脏协会(AHA)模型,对整个左心室的三个短轴切片(基底、中部和根尖)进行全局和节段T1值量化。利用商用软件Cvi42对数据进行后处理和分析。结果心肌T1值为1069.41 ms, SD值为38.73 msec。各年龄组中,<34岁组整体T1值最低(1057 SD 33 msec), 35岁-44岁组整体T1值最高(1100 SD 50 msec),因此年龄的线性增长与松弛时间的变异性之间没有关系。在两性之间,男性的T1值比女性低(1049比1086)。结论原生T1范围可作为局灶性或弥漫性疾病、梗死、贮积性疾病和炎症性疾病患者心肌定量表征的基础。通过CMR,我们离这些技术的临床应用标准化越来越近了。总之,这一分析使我们能够进一步确定它们在拉丁美洲人口中的使用情况。
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引用次数: 0
Measles Case-Based Surveillance Data Analysis Report in Tigray Region, From September 2013 to August 2017 2013年9月至2017年8月提格雷地区麻疹病例监测数据分析报告
Pub Date : 2022-12-22 DOI: 10.33140/jnh.07.04.15
Measles is a highly contagious viral disease which transmitted primarily by respiratory droplets or airborne sprays to mucous membranes in the upper respiratory tract or the conjunctiva. We conducted this surveillance analysis to describe measles distribution by person, place, and time and recommend possible solutions. The Data was secondary data that collected from the National lab EPHI by using concept note that was blood sample sent from Tigray region from September 2013 up to August 2017. Distribution of cases by age and sex (person), description by place and time was made. There was a total of 668 Measles cases and no deaths. From the total of measles sample sent to National EPHI from 2013 to 2017 in Tigray Region the most affected age group is between 15-44 years of age 293(43.9%). The number of confirmed measles were found intermittently increasing and decreasing from year to year. And Measles surveillance system should be strengthening in the Region, especially woredas with high measles cases. But in the study, there were high measles case > 15 years than the underage this needs additional and further study in the region to better understand the age shift.
麻疹是一种传染性极强的病毒性疾病,主要通过呼吸道飞沫或空气中的喷雾传播到上呼吸道粘膜或结膜。我们进行此次监测分析的目的是按人员、地点和时间描述麻疹的分布情况,并提出可能的解决方案。数据是通过使用概念说明从国家实验室 EPHI 收集的二手数据,这些概念说明是自 2013 年 9 月至 2017 年 8 月从提格雷地区发送的血液样本。按年龄、性别(人)、地点和时间对病例进行了分类。共有 668 例麻疹病例,无死亡病例。从 2013 年至 2017 年提格雷大区送往国家 EPHI 的麻疹样本总数来看,受影响最大的年龄组是 15-44 岁的 293 人(43.9%)。确诊的麻疹病例数量呈间歇性增长,并逐年减少。因此,应加强该地区的麻疹监测系统,尤其是麻疹高发区。但在这项研究中,15 岁以上的麻疹病例多于 15 岁以下的病例,这需要在该地区开展更多的进一步研究,以更好地了解年龄的变化。
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引用次数: 0
The Distribution and Drug Resistance Characteristics of Methicillin Resistant Staphylococcus aureous to be Public and Animal Health Burdon in Ethiopia: Systematic Review 埃塞俄比亚耐甲氧西林金黄色葡萄球菌的分布和耐药特征对公共和动物健康的影响:系统综述
Pub Date : 2022-10-02 DOI: 10.33140/jnh.07.04.10
The current meta-analysis was aimed to analyze the prevalence rate of MRSA in S. aureus isolates from different sources of samples in Ethiopia. The multidrug resistance pattern of the pathogen was also one of the outcome of interest of the analysis. The data for the current study were extracted from original research articles published in journals indexed in PubMed databases, accessed online from 12th to 14th December 2021, whose pdf were freely downloadable, English language articles, and conducted on MRSA prevalence in Ethiopia. The data were displayed on Excel spreadsheet, coded, exported to R statistical software and the pooled prevalence of MRSA was calculated per S. aureus isolates and analyzed at 95% CI. Accordingly, 79 eligible articles were selected for the meta-analysis. The result of the study revealed that 26930 samples have been collected from different specimens of which 4219 (15.65%) were S. aureus positive. Of the total S. aureus, 1695 were found MRSA strains and the overall pooled prevalence of MRASA per S. aureus isolates was 40%. In terms of the sources of the specimen, the pooled prevalence of MRSA in human, animal, food and environment were 38%, 15%, 77%, and 54% respectively and it was significantly higher in food and environment than in animal and human samples (p<0.05). The analysis also showed that that MRSA was highly prevalent in patients than in health people (p<0.05). Furthermore, the study revealed that MRSA was highly resistant to cefuroxime (100%), Tobramycin (100%), Neomycin (99%) and Penicillin (92%), Pipracilin (91%), Erythromycin (88%), Bacitracin(84%) and Amoxacilin-clavulanicacid (80%).-However, clindamycin (21%), chloramphenicol (22%), Amikacin (27%), vancomycin (20%), Knamycin (25%) and Ceftriaxone (30%) were antibiotic of relatively better effective against MRSA.
本荟萃分析旨在分析埃塞俄比亚不同来源的金黄色葡萄球菌分离株中MRSA的流行率。病原菌的多药耐药模式也是分析的重要结果之一。本研究的数据提取自发表在PubMed数据库索引期刊上的原始研究论文,这些论文于2021年12月12日至14日在线访问,其pdf可免费下载,并对埃塞俄比亚的MRSA流行情况进行了研究。数据显示在Excel电子表格上,编码,导出到R统计软件,计算每个金黄色葡萄球菌分离株的MRSA总流行率,并以95% CI进行分析。因此,我们选择了79篇符合条件的文章进行meta分析。研究结果显示,共采集了26930份标本,其中4219份(15.65%)呈金黄色葡萄球菌阳性。在所有金黄色葡萄球菌中,发现了1695株MRSA菌株,每株金黄色葡萄球菌MRASA的总流行率为40%。从标本来源来看,MRSA在人、动物、食物和环境中的总流行率分别为38%、15%、77%和54%,食物和环境中的总流行率明显高于动物和人的总流行率(p<0.05)。分析还表明,MRSA在患者中的流行率高于健康人(p<0.05)。此外,研究显示,MRSA对头孢呋辛(100%)、妥布霉素(100%)、新霉素(99%)、青霉素(92%)、匹普拉西林(91%)、红霉素(88%)、杆菌肽(84%)和阿莫西林-克拉维酸(80%)具有高度耐药。-而克林霉素(21%)、氯霉素(22%)、阿米卡星(27%)、万古霉素(20%)、克那霉素(25%)和头孢曲松(30%)是抗MRSA效果相对较好的抗生素。
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引用次数: 0
Implementation of A Telephone Triage System for Management Of Acute Nasal Fracture in Response to The Coronavirus Disease 2019 Pandemic 应对2019冠状病毒病大流行急性鼻骨折电话分诊系统的实施
Pub Date : 2022-10-02 DOI: 10.21203/rs.3.rs-2227606/v1
Background: Acute nasal fracture is a common referral to ENT outpatient clinic. During the Covid-19 pandemic, NHS outpatient services were increasingly stretched and placed patients and staff at risk of Coronavirus. Virtual clinic appointments provided an effective method for reducing Covid-19 risk and improving the efficiency of outpatient services. We sought to implement a telephone triage system for the assessment of nasal fractures. Method A telephone triage pathway for nasal fracture was implemented in October 2021. Data on nasal fracture appointments and outcomes were retrospectively collected for 2 months prior to, and after, the introduction of the telephone triage pathway. All patients with suspected nasal fracture referred to ENT by the Emergency Department at Colchester Hospital were included. Results At baseline, 32 patients were referred for face-to-face (F2F) clinic, 20 (62%) attended and 12 (38%) did-not-attend (DNA). Of those who attended, 17 (85%) were managed conservatively and 3 (15%) had manipulation under anaesthetic (MUA). 24 patients were included in the telephone triage pathway, 13 (54%) attended and 11 (46%) DNA. Of those who attended, 11 (84%) were discharged and 2 (16%) were brought in for F2F assessment. One was managed conservatively and the other had a MUA (8%). The increase in DNA rate from the F2F pathway to the telephone triage pathway was not statistically significant. Conclusion Our data suggests that the telephone triage system for nasal fracture management results in fewer F2F appointments. This reduces COVID-19 transmission to the public and hospital staff but also improves utilisation of outpatient capacity.
背景:急性鼻骨折是耳鼻喉科门诊的常见转诊。在Covid-19大流行期间,NHS门诊服务日益紧张,使患者和工作人员面临冠状病毒的风险。虚拟预约为降低新冠肺炎风险、提高门诊服务效率提供了有效手段。我们试图实施电话分诊系统来评估鼻骨折。方法于2021年10月实施鼻骨折电话分诊通道。在引入电话分诊途径之前和之后的2个月内,回顾性收集鼻骨折预约和结果的数据。所有被科尔切斯特医院急诊科转介到耳鼻喉科的疑似鼻骨折患者均被纳入研究。结果基线时,32例患者转诊至面见(F2F)门诊,20例(62%)就诊,12例(38%)未就诊(DNA)。在这些患者中,17例(85%)采用保守治疗,3例(15%)采用麻醉下操作。24例患者纳入电话分诊路径,13例(54%)参加,11例(46%)DNA。在参加治疗的人中,11人(84%)出院,2人(16%)入院接受F2F评估。一名患者采用保守治疗,另一名患者MUA(8%)。从F2F途径到电话分诊途径,DNA率的增加没有统计学意义。结论电话分诊系统在鼻骨折治疗中减少了F2F预约。这减少了COVID-19向公众和医院工作人员的传播,同时也提高了门诊能力的利用率。
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引用次数: 0
Why are there blood types? why did the antigens develop in the first place? what account for difference in blood types? What account for larger number of rarer non-abo blood types? what role blood types have in fighting disease? 为什么会有血型?为什么抗原首先会产生呢?是什么导致了血型的不同?是什么导致了大量罕见的非abo血型?血型在对抗疾病中有什么作用?
Pub Date : 2022-10-02 DOI: 10.33140/jnh.07.04.07
University : ST.Thomas Abstract DNA Analysis of human Gene on chromosome 22 and gene on chromosome 9 tells blood group formation Types of Blood group 1) A 2) B 3) AB 4) O Male Gene combination of chromosome 22 and female gene chromosome 22 Gene combination on chromosome 9 of male and female
摘要人类22号染色体基因与9号染色体基因的DNA分析揭示血型的形成血型类型1)A型2)B型3)AB型4)O型男性22号染色体基因组合与女性22号染色体基因组合男女9号染色体基因组合
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引用次数: 0
what is biological function of sleep? why do we Dream? What Are Underlying Brain Mechanisms? What Is Its Relation to Anesthesia? 睡眠的生物学功能是什么?我们为什么要做梦?什么是潜在的大脑机制?它与麻醉有什么关系?
Pub Date : 2022-10-02 DOI: 10.33140/jnh.07.04.09
1) Sleep is a neuropsychic state in which metabolism of body is minimum ,growth is maximum ,ageing is least and cell division is high . 2) Subconscious brain is active in sleep which make growth faster by processing and sequencing daily situation . 3) Controlled by melatonin pigmentation
1)睡眠是机体代谢最低、生长最高、衰老最低、细胞分裂最高的一种神经精神状态。2)潜意识大脑在睡眠中是活跃的,通过对日常情况的处理和排序,使大脑生长得更快。3)受褪黑素色素沉着控制
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引用次数: 0
Childhood Depression: - An Update 儿童抑郁症:最新进展
Pub Date : 2022-10-02 DOI: 10.33140/jnh.07.04.04
Childhood depression is a significant public health issue that requires special attention due to the severe and long-lasting effects it has on a child’s development. The diagnosis, treatment, prevention, and prognosis of childhood depression were all topics examined in recent studies. Recent scientific studies on paediatric depression tend to emphasise the detrimental effects of depressive illnesses on children’s quality of life, either directly or indirectly.Sadly, research from the past demonstrates that juvenile depression frequently develops against a backdrop of vulnerability and poverty, where personal and social needs related to childhood melancholy are not always taken into account. In this regard, this review established that co-morbidities and other psychiatric problems are frequently caused by childhood depression.Numerous recent research have also supported the idea that human resources, such as the healthcare system as a whole, lack the necessary training to manage paediatric depression. In order to establish programmes that will train healthcare workers to cope with childhood depression, additional research is required. Additionally, studies that focus on the prevention and treatment of juvenile depression with bigger and more homogeneous sample sizes are also required..
儿童抑郁症是一个重大的公共卫生问题,需要特别关注,因为它对儿童的发展产生严重和持久的影响。儿童抑郁症的诊断、治疗、预防和预后都是近年来研究的主题。最近关于儿童抑郁症的科学研究倾向于强调抑郁症对儿童生活质量的有害影响,无论是直接的还是间接的。可悲的是,过去的研究表明,青少年抑郁症往往是在脆弱和贫困的背景下发展起来的,在这种背景下,与童年忧郁有关的个人和社会需求并不总是得到考虑。在这方面,这篇综述确定了合并症和其他精神问题通常是由儿童抑郁症引起的。最近的许多研究也支持这样一种观点,即人力资源,如整个医疗系统,缺乏必要的培训来管理儿科抑郁症。为了建立培训保健工作者应对儿童抑郁症的方案,需要进行更多的研究。此外,还需要对青少年抑郁症的预防和治疗进行更大、更均匀的样本量研究。
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引用次数: 0
An Overview of the Signs and Symptoms of Pediatric Patients Hospitalized with COVID-19 小儿新冠肺炎住院患者的体征和症状综述
Pub Date : 2022-10-02 DOI: 10.21203/rs.3.rs-2025048/v1
Introduction: Clinical symptoms and laboratory findings of Covid-19 in children are more diverse than in adults. The aim of this study is to determine the clinical and laboratory findings of covid-19 in hospitalized children. Materials and methods This cross-sectional descriptive study was conducted on 57 children aged 1 month to 12 years who were admitted with Covid-19, and their diagnosis were confirmed by PCR method from March 2020 to November 2021 in Mousavi Hospital of Zanjan, Iran. Demographic data, clinical and laboratory findings of patients were recorded, and relevant information was analyzed. Results In this study, 57 children with Covid-19, PCR positive, including 26 boys (45.6%) and 31 girls (54.4%) were evaluated. The most common clinical findings were fever, cough , respiratory distress, vomiting, diarrhea and seizures with fever in 45 (78.9%), 30 (52.6 ),24 (42.1%) , 21 (36.8%) ,18 (31.5) and 6 (10.5%) patients respectively. The most common laboratory findings were increased AST and ALT in 50 (87.7%) and 24 (42.1%) patients. Increased CRP and ESR were found in 21 (36.8%) and 15 (26.3%) patients, respectively. Lymphopenia and thrombocytopenia were reported in 14 (24.5%) and 4 (7.07%) patients, respectively. Conclusion The most common clinical manifestations of covid-19 in children were fever and cough. The increase of liver enzymes, especially AST, was significant in hospitalized children, while lymphopenia and thrombocytopenia were not common in affected children.
儿童Covid-19的临床症状和实验室结果比成人更多样化。本研究的目的是确定住院儿童covid-19的临床和实验室结果。材料与方法本研究对2020年3月至2021年11月伊朗赞詹穆萨维医院收治的57例1个月至12岁的Covid-19患儿进行了横断面描述性研究。记录患者的人口学资料、临床和实验室检查结果,并对相关信息进行分析。结果本研究共检测到57例新冠肺炎患儿,其中男孩26例(45.6%),女孩31例(54.4%)。最常见的临床表现为发热、咳嗽、呼吸窘迫、呕吐、腹泻和癫痫伴发热45例(78.9%)、30例(52.6)、24例(42.1%)、21例(36.8%)、18例(31.5)和6例(10.5%)。50例(87.7%)和24例(42.1%)患者最常见的实验室结果是AST和ALT升高。CRP和ESR升高的患者分别为21例(36.8%)和15例(26.3%)。淋巴细胞减少14例(24.5%),血小板减少4例(7.07%)。结论儿童新冠肺炎最常见的临床表现为发热和咳嗽。住院患儿肝酶,尤其是谷草转氨酶明显升高,而淋巴细胞减少和血小板减少在患儿中并不常见。
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引用次数: 0
Virus is Living and Its Treatment 病毒是活的及其治疗方法
Pub Date : 2022-10-02 DOI: 10.33140/jnh.07.04.08
Aim: To prove virus living. Aim: DNA combination of cell. Material re quired: Blood samples of two different animals. Theory: Two blood signatures of two animal combine when large amount of iron is added with two animal DNA signature and hormones are mixed with each other. By this way new type of hormones and blood signature is created. Procedure: 1 Take blood samples of two animals. 2. Mix their hormones with animals. 3. Mix iron with in blood solution. 4. Inject in frog. Result: 1. Frog shows some changes in it. 2. Blood hormones get mixed with it. 3. DNA signature combined.
目的:证明病毒存活。目的:细胞DNA组合。所需材料:两种不同动物的血液样本。理论:当两种动物的DNA标记和激素混合在一起并加入大量的铁时,两种动物的两种血液标记就会结合在一起。通过这种方式,新的激素和血液特征被创造出来。操作步骤:1取两只动物的血液样本。2. 把他们的荷尔蒙和动物混合。3.将铁与血液溶液混合。4. 注射到青蛙体内。结果:1。青蛙展示了它的一些变化。2. 血液中的荷尔蒙和它混合在一起。3.DNA签名组合。
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引用次数: 0
期刊
Journal of Nursing &amp; Healthcare
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