E. Gur, Y. Tiftikcioglu, Turgut Furkan Kuybulu, Kutay Durukan, M. Yeğin, N. Ozkayin
Background/Aim: The power of free flaps for lower extremity injury reconstruction is no longer a matter of debate; however, contrasting views remain regarding the timing of reconstruction. The mainstay article of Godina reported that reconstruction within the first three days after injury was more advantageous than surgery at later times, but different views about the best day for reconstruction have also been described in the literature. With developments in the field of microsurgery, plastic surgeons have become more experienced, shortened the times needed for surgery, and achieved flap success. We have also become more experienced with surgical times, and reconstruction on the day of injury has been performed as an emergency reconstruction (ER) procedure since 2018. However, despite the disadvantages of a delayed wait period, patients still experience delayed reconstruction (DR) due to their pre-operative conditions and dispatches from peripheral centers over delayed time periods. This study aimed to present our experiences with lower extremity reconstruction in emergency situations and after delayed periods with descriptions of technical tips for each situation. Methods: Between 2018 and 2021, patients who underwent lower extremity reconstructions were examined as retrospective case-control study. Twenty-four patients (17 male and seven female) underwent lower extremity reconstructions with microsurgical free flap coverage. Patients’ ages ranged from 6 to 75 years old. Ten patients underwent ERs (on the day of injury), and 14 patients underwent DRs. Twenty anterolateral thigh, two medial sural artery perforator, one latissimus dorsi, and one radial forearm flaps were chosen for reconstructions. Flaps were chosen for one-third of the distal lower extremity reconstructions (n=11) and Gustilo type 3B injuries (n=11), Gustilo type 3C injuries (n=1), and one-third for middle lower extremity soft tissue reconstructions (n=1). Infections, length of hospital stays, time spent during the reconstructive surgery, vascular complications, and additional debridement necessity counts were recorded and compared with previous statistical analyses. Results: One venous thrombosis in the emergency group and three venous and one arterial thrombosis in the delayed group were reported. The patients were taken to the operating room immediately after which re-anastomoses were performed successfully, and all flaps survived. The hospital stay was between 4 and 60 days in the emergency group and 20 and 99 days in delayed group. Infections (P=0.03), vascular complications (P=0.04), and hospital stays (P=0.01) were statistically significantly lower in the emergency group than in the delayed group. Conclusion: ER has many advantages, such as preventing time consuming surgeries and providing short hospital stays and low complication rates, over DR. However, DR is inevitable for some reasons, and despite its more complicated nature, meticulous flap follow-up and salvage proc
{"title":"Emergency and delayed microsurgical salvage of traumatic lower extremities","authors":"E. Gur, Y. Tiftikcioglu, Turgut Furkan Kuybulu, Kutay Durukan, M. Yeğin, N. Ozkayin","doi":"10.28982/josam.7613","DOIUrl":"https://doi.org/10.28982/josam.7613","url":null,"abstract":"Background/Aim: The power of free flaps for lower extremity injury reconstruction is no longer a matter of debate; however, contrasting views remain regarding the timing of reconstruction. The mainstay article of Godina reported that reconstruction within the first three days after injury was more advantageous than surgery at later times, but different views about the best day for reconstruction have also been described in the literature. With developments in the field of microsurgery, plastic surgeons have become more experienced, shortened the times needed for surgery, and achieved flap success. We have also become more experienced with surgical times, and reconstruction on the day of injury has been performed as an emergency reconstruction (ER) procedure since 2018. However, despite the disadvantages of a delayed wait period, patients still experience delayed reconstruction (DR) due to their pre-operative conditions and dispatches from peripheral centers over delayed time periods. This study aimed to present our experiences with lower extremity reconstruction in emergency situations and after delayed periods with descriptions of technical tips for each situation.\u0000Methods: Between 2018 and 2021, patients who underwent lower extremity reconstructions were examined as retrospective case-control study. Twenty-four patients (17 male and seven female) underwent lower extremity reconstructions with microsurgical free flap coverage. Patients’ ages ranged from 6 to 75 years old. Ten patients underwent ERs (on the day of injury), and 14 patients underwent DRs. Twenty anterolateral thigh, two medial sural artery perforator, one latissimus dorsi, and one radial forearm flaps were chosen for reconstructions. Flaps were chosen for one-third of the distal lower extremity reconstructions (n=11) and Gustilo type 3B injuries (n=11), Gustilo type 3C injuries (n=1), and one-third for middle lower extremity soft tissue reconstructions (n=1). Infections, length of hospital stays, time spent during the reconstructive surgery, vascular complications, and additional debridement necessity counts were recorded and compared with previous statistical analyses.\u0000Results: One venous thrombosis in the emergency group and three venous and one arterial thrombosis in the delayed group were reported. The patients were taken to the operating room immediately after which re-anastomoses were performed successfully, and all flaps survived. The hospital stay was between 4 and 60 days in the emergency group and 20 and 99 days in delayed group. Infections (P=0.03), vascular complications (P=0.04), and hospital stays (P=0.01) were statistically significantly lower in the emergency group than in the delayed group.\u0000Conclusion: ER has many advantages, such as preventing time consuming surgeries and providing short hospital stays and low complication rates, over DR. However, DR is inevitable for some reasons, and despite its more complicated nature, meticulous flap follow-up and salvage proc","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80647063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: This study aimed to evaluate the methodological quality of randomized controlled trials (RCTs) that examine home-based rehabilitation (HBR) trials for knee osteoarthritis (KOA) using the Physiotherapy Evidence Database (PEDro) scale and the nine methodology-related items of the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement. Methods: Three electronic databases were scanned from baseline to October 10, 2021. Two reviewers independently evaluated the articles according to the two inclusion criteria: (1) in individuals diagnosed with KOA, at least one group received home-based rehabilitation as a study intervention and (2) at least one group received a comparison intervention or no intervention. The methodological quality of the included studies (n=22) was assessed using the PEDro scale and nine items of the CONSORT 2010 statement. Results: Among 1557 RCTs, 22 studies that fulfilled our criteria were included in the review. The mean PEDro scale score was 5.77 (1.54). This result reflects moderate methodological quality. Concealed allocation (6; 27.3%), blinding of subjects (4; 18.2%), and (0; 0.0%) of therapists associated with the methodological quality were not reported in most studies. An author’s expertise in epidemiology and/or statistics was 0.78 points (95% confidence interval [CI] 0.11–1.44), the multicenter study 0.94 points (95% CI: 0.19–1.68), and a one-unit increase in the total score of the CONSORT statement led to an increase in methodological quality of 0.55 points (95% CI: 0.34–0.76). Conclusion: The methodological quality of most RCTs examining HBR in KOA that we included in our systematic review was moderate. The adherence of journals and authors to CONSORT checklists in reporting of studies may lead to an improvement in the methodological quality of future published studies.
{"title":"Methodological quality of randomized controlled trials of home-based rehabilitation in knee osteoarthritis: A cross-sectional survey","authors":"Caglar Meran Meltem, Unver Bayram, Caglar Engin","doi":"10.28982/josam.1114280","DOIUrl":"https://doi.org/10.28982/josam.1114280","url":null,"abstract":"Background/Aim: This study aimed to evaluate the methodological quality of randomized controlled trials (RCTs) that examine home-based rehabilitation (HBR) trials for knee osteoarthritis (KOA) using the Physiotherapy Evidence Database (PEDro) scale and the nine methodology-related items of the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement. \u0000Methods: Three electronic databases were scanned from baseline to October 10, 2021. Two reviewers independently evaluated the articles according to the two inclusion criteria: (1) in individuals diagnosed with KOA, at least one group received home-based rehabilitation as a study intervention and (2) at least one group received a comparison intervention or no intervention. The methodological quality of the included studies (n=22) was assessed using the PEDro scale and nine items of the CONSORT 2010 statement. \u0000Results: Among 1557 RCTs, 22 studies that fulfilled our criteria were included in the review. The mean PEDro scale score was 5.77 (1.54). This result reflects moderate methodological quality. Concealed allocation (6; 27.3%), blinding of subjects (4; 18.2%), and (0; 0.0%) of therapists associated with the methodological quality were not reported in most studies. An author’s expertise in epidemiology and/or statistics was 0.78 points (95% confidence interval [CI] 0.11–1.44), the multicenter study 0.94 points (95% CI: 0.19–1.68), and a one-unit increase in the total score of the CONSORT statement led to an increase in methodological quality of 0.55 points (95% CI: 0.34–0.76). \u0000Conclusion: The methodological quality of most RCTs examining HBR in KOA that we included in our systematic review was moderate. The adherence of journals and authors to CONSORT checklists in reporting of studies may lead to an improvement in the methodological quality of future published studies.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87224448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Onur, T. Onur, Ü. Karaca, H. Sayan, Canan Yılmaz, Nermin Kılıçarslan
Background/Aim: Optic nerve sheath diameter (ONSD) is a surrogate parameter for intracranial pressure. This study evaluated the effect of anesthetics on ONSD in women undergoing surgery. We aimed to measure the effect of minimal and high flow anesthesia techniques on expiratory/inspiratory oxygen and carbon dioxide fraction values, hemodynamic parameters, and the optic nerve sheath diameter by ultrasonography in open gynecological surgeries. Methods: In the present prospective cohort study, 80 patients who planned laparotomic gynecological surgery were divided into two groups: a high flow of 2 L/min and a minimum flow of 0.5 L/min. Anesthesia was maintained with 50% oxygen-50% air at 2 L/min and desflurane at 1.1 MAC in Group 1 (n=40) and 50% oxygen-50% air at 0.5 L/min and desflurane at 1.1 MAC in Group 2 (n=40). After 10–15 min, group 2 was administered minimal flow with 50–60% oxygen and 40–50% air at 0.5 L/min desflurane, and 10 min before the end of the surgery, the patients were switched to high flow with 50% oxygen-50% air at 2 L/min. Results: Decreasing heart rates were higher in Group 2 (T0 P=0.001, T2 P=0.007, T3 P=0.035). There was a significant positive correlation between EtCO2 at the 60th min and optic nerve sheath diameter measurements in the minimal flow group (left ONSD r=0.440, P=0.004, right ONSD r=0.473, P=0.002). Although inspiratory oxygen values in Group 2 did not fall below 32%, it was lower than Group 1 except for the last measurement time. Conclusion: Minimal flow anesthesia is as safe as high flow in terms of effects on optic nerve sheath diameter and oxygenation parameters in laparotomic gynecological surgery.
{"title":"The effect of minimal and high flow anesthesia on optic nerve sheath diameter in laparotomic gynecological surgery","authors":"A. Onur, T. Onur, Ü. Karaca, H. Sayan, Canan Yılmaz, Nermin Kılıçarslan","doi":"10.28982/josam.1123380","DOIUrl":"https://doi.org/10.28982/josam.1123380","url":null,"abstract":"Background/Aim: Optic nerve sheath diameter (ONSD) is a surrogate parameter for intracranial pressure. This study evaluated the effect of anesthetics on ONSD in women undergoing surgery. We aimed to measure the effect of minimal and high flow anesthesia techniques on expiratory/inspiratory oxygen and carbon dioxide fraction values, hemodynamic parameters, and the optic nerve sheath diameter by ultrasonography in open gynecological surgeries. \u0000Methods: In the present prospective cohort study, 80 patients who planned laparotomic gynecological surgery were divided into two groups: a high flow of 2 L/min and a minimum flow of 0.5 L/min. Anesthesia was maintained with 50% oxygen-50% air at 2 L/min and desflurane at 1.1 MAC in Group 1 (n=40) and 50% oxygen-50% air at 0.5 L/min and desflurane at 1.1 MAC in Group 2 (n=40). After 10–15 min, group 2 was administered minimal flow with 50–60% oxygen and 40–50% air at 0.5 L/min desflurane, and 10 min before the end of the surgery, the patients were switched to high flow with 50% oxygen-50% air at 2 L/min. \u0000Results: Decreasing heart rates were higher in Group 2 (T0 P=0.001, T2 P=0.007, T3 P=0.035). There was a significant positive correlation between EtCO2 at the 60th min and optic nerve sheath diameter measurements in the minimal flow group (left ONSD r=0.440, P=0.004, right ONSD r=0.473, P=0.002). Although inspiratory oxygen values in Group 2 did not fall below 32%, it was lower than Group 1 except for the last measurement time. \u0000Conclusion: Minimal flow anesthesia is as safe as high flow in terms of effects on optic nerve sheath diameter and oxygenation parameters in laparotomic gynecological surgery.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83514605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ertuğrul Demirdel, A. Ceylan, Hüsamettin Koçak, M.A. Güler, Tahsin Can Türker, Senem Demirdel
Background/Aim: The transition to distance education due to the coronavirus-19 restrictions changed the routines of university students, and physical activity and sleep status were affected due to increased computer screen use. Determining the factors affecting the sleep quality and musculoskeletal pain of university students during the pandemic period will guide the measures that can be taken to address these changes. The aim of this study was to investigate sleep quality and musculoskeletal pain of university students during the pandemic. Our research asked, “What are the factors affecting sleep quality during the pandemic period and does a difference between the musculoskeletal pain of those with good and bad sleep quality exist?” Methods: University students receiving distance education were included in this cross-sectional study. Students’ demographic characteristics, exercise habits, daily use of smart mobile devices were questioned via an online form. The Pittsburgh Sleep Quality Index was used to evaluate sleep quality, and the Cornell Musculoskeletal Discomfort Questionnaire was used to evaluate musculoskeletal pain. Sleep quality status based on regular exercise and daily mobile device usage time were compared. In addition, the musculoskeletal discomforts of the participants with good or bad sleep quality were compared. Results: Two-hundred twenty-one university students were included in the study (187 female, 34 male). Sleep quality was better in those who exercised regularly (P=0.005). Subjective sleep quality and sleep latency scores were better for those who used smart mobile devices less than 5 h a day (P=0.002 and P=0.018, respectively). Those with good sleep quality had less musculoskeletal discomfort (P<0.001). Conclusion: The findings of our study showed that increased physical inactivity and smart mobile device use during the distance education period negatively affect sleep quality. Since those with poor sleep quality have more musculoskeletal pain, we think that preventive measures, such as reducing screen time and inactivity, should be taken in distance education students to prevent health problems that may be associated with poor sleep status.
{"title":"Investigation of sleep quality and musculoskeletal pain of university students during the pandemic period","authors":"Ertuğrul Demirdel, A. Ceylan, Hüsamettin Koçak, M.A. Güler, Tahsin Can Türker, Senem Demirdel","doi":"10.28982/josam.1101380","DOIUrl":"https://doi.org/10.28982/josam.1101380","url":null,"abstract":"Background/Aim: The transition to distance education due to the coronavirus-19 restrictions changed the routines of university students, and physical activity and sleep status were affected due to increased computer screen use. Determining the factors affecting the sleep quality and musculoskeletal pain of university students during the pandemic period will guide the measures that can be taken to address these changes. The aim of this study was to investigate sleep quality and musculoskeletal pain of university students during the pandemic. Our research asked, “What are the factors affecting sleep quality during the pandemic period and does a difference between the musculoskeletal pain of those with good and bad sleep quality exist?” \u0000Methods: University students receiving distance education were included in this cross-sectional study. Students’ demographic characteristics, exercise habits, daily use of smart mobile devices were questioned via an online form. The Pittsburgh Sleep Quality Index was used to evaluate sleep quality, and the Cornell Musculoskeletal Discomfort Questionnaire was used to evaluate musculoskeletal pain. Sleep quality status based on regular exercise and daily mobile device usage time were compared. In addition, the musculoskeletal discomforts of the participants with good or bad sleep quality were compared. \u0000Results: Two-hundred twenty-one university students were included in the study (187 female, 34 male). Sleep quality was better in those who exercised regularly (P=0.005). Subjective sleep quality and sleep latency scores were better for those who used smart mobile devices less than 5 h a day (P=0.002 and P=0.018, respectively). Those with good sleep quality had less musculoskeletal discomfort (P<0.001). \u0000Conclusion: The findings of our study showed that increased physical inactivity and smart mobile device use during the distance education period negatively affect sleep quality. Since those with poor sleep quality have more musculoskeletal pain, we think that preventive measures, such as reducing screen time and inactivity, should be taken in distance education students to prevent health problems that may be associated with poor sleep status.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88944675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: Cuffed-tunneled catheter patients encounter various problems during their catheterization period. Early detection and resolution of these problems prolong the life of the catheter. The purpose of the present study was to investigate the problems and solution methods of cuffed-tunneled catheters in hemodialysis patients during their use in light of our experience and literature. Methods: The study was designed as a retrospective cohort study. Twenty-four months of patient data who had a diagnosis of renal failure and who received cuffed-tunneled hemodialysis catheters between January 2013 and June 21 in the Department of Cardiovascular Surgery of Adiyaman University Faculty of Medicine were analyzed electronically based on the hospital data recording system. The demographic characteristics, localization of the inserted catheter, and duration of catheter use were determined. Primary and secondary patency ratios were calculated and recorded along with the complications in the patients and our treatment approaches to these complications. Finally, the collected data were discussed with reference to the literature data. Results: The data from 322 cuffed-tunneled catheters were collected in a total of 228 patients during the observation period. It was found that no revision procedure was applied to 73 patients (catheter) during the 24-month period, and a total of 204 revision procedures were applied to 155 patients. The revision procedure consisted of 110 thrombolytic treatments, 64 vein exchanges, 18 tunnel changes, and 12 catheter changes. Primary and secondary patency ratios at 6, 12, 18, and 24 months were calculated as 90.79%, 63.60%, 40.11%, and 32.02% and 96.05%, 89.91%, 72.37%, and 58.33%, respectively. The most common factors that affected primary and secondary patency ratios were determined to be gender (P<0.001 and P=0.056, respectively), body mass index (P<0.001 and P<0.001, respectively) and diabetes mellitus (P=0.018 and P=0.690, respectively). Conclusion: Thrombolytic treatment is an effective and safe method in catheter thrombosis, which is one of the most important factors rendering the cuffed-tunneled hemodialysis catheters dysfunctional. Also, in tunnel infections, tunnel replacement is a salvage procedure in patients with vascular access problems.
{"title":"Cuffed-tunneled catheters in hemodialysis patients: problems and solution methods: A single-center retrospective cohort study","authors":"Mumtaz Murat Yardimci, C. Güven","doi":"10.28982/josam.7604","DOIUrl":"https://doi.org/10.28982/josam.7604","url":null,"abstract":"Background/Aim: Cuffed-tunneled catheter patients encounter various problems during their catheterization period. Early detection and resolution of these problems prolong the life of the catheter. The purpose of the present study was to investigate the problems and solution methods of cuffed-tunneled catheters in hemodialysis patients during their use in light of our experience and literature.\u0000Methods: The study was designed as a retrospective cohort study. Twenty-four months of patient data who had a diagnosis of renal failure and who received cuffed-tunneled hemodialysis catheters between January 2013 and June 21 in the Department of Cardiovascular Surgery of Adiyaman University Faculty of Medicine were analyzed electronically based on the hospital data recording system. The demographic characteristics, localization of the inserted catheter, and duration of catheter use were determined. Primary and secondary patency ratios were calculated and recorded along with the complications in the patients and our treatment approaches to these complications. Finally, the collected data were discussed with reference to the literature data.\u0000Results: The data from 322 cuffed-tunneled catheters were collected in a total of 228 patients during the observation period. It was found that no revision procedure was applied to 73 patients (catheter) during the 24-month period, and a total of 204 revision procedures were applied to 155 patients. The revision procedure consisted of 110 thrombolytic treatments, 64 vein exchanges, 18 tunnel changes, and 12 catheter changes. Primary and secondary patency ratios at 6, 12, 18, and 24 months were calculated as 90.79%, 63.60%, 40.11%, and 32.02% and 96.05%, 89.91%, 72.37%, and 58.33%, respectively. The most common factors that affected primary and secondary patency ratios were determined to be gender (P<0.001 and P=0.056, respectively), body mass index (P<0.001 and P<0.001, respectively) and diabetes mellitus (P=0.018 and P=0.690, respectively).\u0000Conclusion: Thrombolytic treatment is an effective and safe method in catheter thrombosis, which is one of the most important factors rendering the cuffed-tunneled hemodialysis catheters dysfunctional. Also, in tunnel infections, tunnel replacement is a salvage procedure in patients with vascular access problems.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81726787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. K. Çekok, A. Aktaş, Öznur Fidan, Serpilnur Avar
Background/Aim: There are no studies examining quality of life, anxiety levels, physical activities, and Covid-19 fear levels in people with cancer. The aim of this study was to examine physical activity status, coronavirus fear levels, and quality of life in oncological individuals during the COVID-19 pandemic. Methods: This study was conducted among oncology patients. The level of physical activity was assessed using the Rapid Assessment of Physical Activity Scale (RAPA 1), the level of fear with the Fear of COVID-19 Scale (FCV-19S), and the quality of life with the COVID-19 Impact on Quality of Life Scale (COV19-QoLTR). Results: The study was completed by 78 patients. Thirty-eight patients tested positive for COVID-19. Patients who tested positive for COVID-19 had significantly higher FCV-19S and COV19-QoL scores and lower scores of RAPA 1 (P<0.001). Also, FCV-19S was positively correlated with COV19-QoLTR and negatively correlated with RAPA 1 scores (P<0.001). Conclusions: These findings suggest the need for more clarity and tailoring of physical activity-related advice for oncology patients with COVID-19 and improved support to resume activities important to individual well-being.
{"title":"Investigation of the level of physical activity, coronavirus fear, and quality of life in oncology patients during the COVID-19 pandemic: A cross-sectional study","authors":"F. K. Çekok, A. Aktaş, Öznur Fidan, Serpilnur Avar","doi":"10.28982/josam.1114657","DOIUrl":"https://doi.org/10.28982/josam.1114657","url":null,"abstract":"Background/Aim: There are no studies examining quality of life, anxiety levels, physical activities, and Covid-19 fear levels in people with cancer. The aim of this study was to examine physical activity status, coronavirus fear levels, and quality of life in oncological individuals during the COVID-19 pandemic. \u0000Methods: This study was conducted among oncology patients. The level of physical activity was assessed using the Rapid Assessment of Physical Activity Scale (RAPA 1), the level of fear with the Fear of COVID-19 Scale (FCV-19S), and the quality of life with the COVID-19 Impact on Quality of Life Scale (COV19-QoLTR). \u0000Results: The study was completed by 78 patients. Thirty-eight patients tested positive for COVID-19. Patients who tested positive for COVID-19 had significantly higher FCV-19S and COV19-QoL scores and lower scores of RAPA 1 (P<0.001). Also, FCV-19S was positively correlated with COV19-QoLTR and negatively correlated with RAPA 1 scores (P<0.001). \u0000Conclusions: These findings suggest the need for more clarity and tailoring of physical activity-related advice for oncology patients with COVID-19 and improved support to resume activities important to individual well-being.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82130407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: JAK2 is a gene that provides instructions for making a protein called Janus kinase 2, which is involved in the signaling process that regulates the growth and division of cells. Variations in the JAK2 gene have been associated with several different diseases, including certain blood disorders like myeloproliferative neoplasms (MPNs) and ulcerative colitis (UC). The exact reason for ulcerative colitis is not fully understood. This study aimed to examine the possible role of JAK2 V617F mutation in the etiopathogenesis of ulcerative colitis. Methods: The included patients were selected with UC and with signs of thrombosis. The DNA isolation was carried out from peripheral blood for all included patients. RT-qPCR methods were used to find JAK2 V617F mutations in UC patients with signs of thrombosis. Results: 73.3% of the included patients in this study had 73.3% bloody diarrhea and 80% had abdominal pain. Also, the JAK2 V617F mutation rate was detected in 6.6 % of the patients included in the study. Conclusion: In this study, it was found that the V617F mutation was relatively rare in ulcerative colitis patients and there was no correlation with the JAK2 V617F mutation in most of the ulcerative colitis cases with thrombotic symptoms.
{"title":"An investigation of JAK2 mutation in patients with ulcerative colitis with a history of thrombosis","authors":"Tahir Buran, M. B. Batır, F. Çam, E. Kasap","doi":"10.28982/josam.7771","DOIUrl":"https://doi.org/10.28982/josam.7771","url":null,"abstract":"Background/Aim: JAK2 is a gene that provides instructions for making a protein called Janus kinase 2, which is involved in the signaling process that regulates the growth and division of cells. Variations in the JAK2 gene have been associated with several different diseases, including certain blood disorders like myeloproliferative neoplasms (MPNs) and ulcerative colitis (UC). The exact reason for ulcerative colitis is not fully understood. This study aimed to examine the possible role of JAK2 V617F mutation in the etiopathogenesis of ulcerative colitis.\u0000Methods: The included patients were selected with UC and with signs of thrombosis. The DNA isolation was carried out from peripheral blood for all included patients. RT-qPCR methods were used to find JAK2 V617F mutations in UC patients with signs of thrombosis.\u0000Results: 73.3% of the included patients in this study had 73.3% bloody diarrhea and 80% had abdominal pain. Also, the JAK2 V617F mutation rate was detected in 6.6 % of the patients included in the study.\u0000Conclusion: In this study, it was found that the V617F mutation was relatively rare in ulcerative colitis patients and there was no correlation with the JAK2 V617F mutation in most of the ulcerative colitis cases with thrombotic symptoms.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89044333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: Azoospermia is defined as the absence of sperm in semen and is one of the most common causes of male infertility, with a prevalence of 10-15% in infertile men. Conventional methods for semen analysis do not provide a clear understanding of the etiology of azoospermia. Although testicular biopsy may exclude obstructive cases, non-obstructive azoospermia (NOA) treatment is limited due to a limited understanding of the underlying molecular mechanisms. Analysis of genetic alterations in azoospermia patients compared to the fertile population may be a valuable tool for determining diagnostic biomarkers for male infertility. This study aims to use bioinformatic tools to determine the top candidates in certain pathways altered in azoospermia. Methods: Expression data (GSE108886) of the differential testicular transcriptome in patients with NOA was selected from the Gene Expression Omnibus (GEO) database. Testicular RNA was harvested from azoospermia patients (n=11) and healthy controls (n=1, pooled sample). The differentially expressed genes (DEGs) were examined using GEO2R software. Biological pathways were identified through the Kyoto Encyclopedia of Genes and Genomes (KEGG). Construction of the protein network and detection of hub genes were conducted in the STRING database. Data validation was performed via ELISA assay for the FOXO3 gene in obstructive and NOA patients. Significance was set at P-value <0.05. Results: In NOA patients, 2115 genes were upregulated, and 1753 genes were downregulated compared to the control group. Ninety-one genes involved in spermatogenesis were downregulated. KEGG analysis revealed that the glucagon signaling, AMPK signaling, insulin and estrogen signaling, and oocyte meiosis pathways were upregulated, while the regulation of actin cytoskeleton, MAPK signaling pathway, focal adhesion, and chemical carcinogenesis – reactive oxygen species pathways were downregulated. Downstream genes with the highest score were PSMA4, PSMA6, PSMC1, PSME4, and UBA52, which are responsible for the ubiquitin-dependent protein degradation. The top hub genes with increasing expression were RPS18, RPS2, and RPS4X Conclusion: Although hub genes selected within the altering pathways may serve as a diagnostic tool for NOA, further validation of the presented data is necessary, as protein-protein interactions may not reflect alterations in gene expression in vivo.
背景/目的:无精子症被定义为精液中没有精子，是男性不育的最常见原因之一，在不育男性中患病率为10-15%。传统的精液分析方法不能清楚地了解无精子症的病因。尽管睾丸活检可以排除梗阻性病例，但由于对潜在分子机制的了解有限，非梗阻性无精子症(NOA)的治疗受到限制。分析无精子症患者与可生育人群的遗传改变可能是确定男性不育诊断生物标志物的有价值的工具。本研究旨在使用生物信息学工具来确定无精子症中某些途径改变的最佳候选基因。方法:从Gene Expression Omnibus (GEO)数据库中选择NOA患者差异睾丸转录组的表达数据(GSE108886)。从无精子症患者(n=11)和健康对照(n=1，合并样本)中收集睾丸RNA。用GEO2R软件检测差异表达基因(DEGs)。通过京都基因与基因组百科全书(KEGG)确定了生物学途径。在STRING数据库中构建蛋白网络并检测枢纽基因。通过酶联免疫吸附试验(ELISA)对阻塞性和NOA患者的FOXO3基因进行验证。p值<0.05为显著性。结果:与对照组相比，NOA患者有2115个基因表达上调，1753个基因表达下调。91个与精子发生有关的基因被下调。KEGG分析显示，胰高血糖素信号通路、AMPK信号通路、胰岛素和雌激素信号通路、卵母细胞减数分裂通路上调，肌动蛋白细胞骨架、MAPK信号通路、局灶黏着、化学致癌-活性氧信号通路下调。下游得分最高的基因是负责泛素依赖性蛋白降解的PSMA4、PSMA6、PSMC1、PSME4和UBA52。结论:虽然在改变途径中选择的中心基因可能作为NOA的诊断工具，但由于蛋白质-蛋白质相互作用可能不能反映体内基因表达的改变，因此需要进一步验证所提供的数据。
{"title":"Genetic alterations in azoospermia patients may reveal potential biomarkers for male infertility: A bioinformatic study","authors":"Duru Aras-Tosun","doi":"10.28982/josam.7748","DOIUrl":"https://doi.org/10.28982/josam.7748","url":null,"abstract":"Background/Aim: Azoospermia is defined as the absence of sperm in semen and is one of the most common causes of male infertility, with a prevalence of 10-15% in infertile men. Conventional methods for semen analysis do not provide a clear understanding of the etiology of azoospermia. Although testicular biopsy may exclude obstructive cases, non-obstructive azoospermia (NOA) treatment is limited due to a limited understanding of the underlying molecular mechanisms. Analysis of genetic alterations in azoospermia patients compared to the fertile population may be a valuable tool for determining diagnostic biomarkers for male infertility. This study aims to use bioinformatic tools to determine the top candidates in certain pathways altered in azoospermia.\u0000Methods: Expression data (GSE108886) of the differential testicular transcriptome in patients with NOA was selected from the Gene Expression Omnibus (GEO) database. Testicular RNA was harvested from azoospermia patients (n=11) and healthy controls (n=1, pooled sample). The differentially expressed genes (DEGs) were examined using GEO2R software. Biological pathways were identified through the Kyoto Encyclopedia of Genes and Genomes (KEGG). Construction of the protein network and detection of hub genes were conducted in the STRING database. Data validation was performed via ELISA assay for the FOXO3 gene in obstructive and NOA patients. Significance was set at P-value <0.05.\u0000Results: In NOA patients, 2115 genes were upregulated, and 1753 genes were downregulated compared to the control group. Ninety-one genes involved in spermatogenesis were downregulated. KEGG analysis revealed that the glucagon signaling, AMPK signaling, insulin and estrogen signaling, and oocyte meiosis pathways were upregulated, while the regulation of actin cytoskeleton, MAPK signaling pathway, focal adhesion, and chemical carcinogenesis – reactive oxygen species pathways were downregulated. Downstream genes with the highest score were PSMA4, PSMA6, PSMC1, PSME4, and UBA52, which are responsible for the ubiquitin-dependent protein degradation. The top hub genes with increasing expression were RPS18, RPS2, and RPS4X\u0000Conclusion: Although hub genes selected within the altering pathways may serve as a diagnostic tool for NOA, further validation of the presented data is necessary, as protein-protein interactions may not reflect alterations in gene expression in vivo.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75411747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermoid cysts are one of the most common causes of ovarian torsion. The causes of acute abdominal pain are mostly caused by the diagnosis of acute appendicitis, acute pancreatitis, and mesenteric ischemia, and the incidence of ovarian torsion is not known exactly. Although ovarian torsion is very rare, it ranks first among the indications for gynecological emergency surgery. A rare case of a non-ruptured dermoid cyst causing ovarian torsion in the emergency room is presented.
{"title":"A rare cause of acute abdomen: Ovarian torsion due to dermoid cyst","authors":"H. Akça, D. Atik, Fulya Köse","doi":"10.28982/josam.1114138","DOIUrl":"https://doi.org/10.28982/josam.1114138","url":null,"abstract":"Dermoid cysts are one of the most common causes of ovarian torsion. The causes of acute abdominal pain are mostly caused by the diagnosis of acute appendicitis, acute pancreatitis, and mesenteric ischemia, and the incidence of ovarian torsion is not known exactly. Although ovarian torsion is very rare, it ranks first among the indications for gynecological emergency surgery. A rare case of a non-ruptured dermoid cyst causing ovarian torsion in the emergency room is presented.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"219 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75091105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Köse, M. Topal, S. Yılar, Muhammet Çağatay Engin, Ö. Yıldırım, Alperen Zeynel
Background/Aim: Open reduction (OR) and Pemberton’s periacetabular osteotomy (PPO) are efficient and reliable methods for treating late-diagnosed developmental dysplasia of the hip. However, various studies have reported an avascular necrosis (AVN) rate of up to 80% with this technique, which is increased in Tönnis type 4 hips. In this study, we hypothesized that femoral shortening osteotomy (FSO) would reduce the rates of AVN by decreasing the post-reduction pressure on the femoral head. Methods: In this retrospective cohort study, we reviewed patients who had undergone OR and PPO between 2006 and 2016. Only hips with Tönnis type 4 dislocation were included. The subjects were divided into two groups: Group 1, who had undergone OR+PPO, and Group 2, who had undergone OR+PPO+FSO. The Kalamchi-MacEwen system was used for AVN classification. The groups were compared regarding the pre- and postoperative acetabular indices and the rate of AVN and other complications. Results: We included 76 hips of 50 patients who met the inclusion criteria in the study. Group 1 consisted of 46 hips of 32 patients, and Group 2 consisted of 30 hips of 18 patients. The mean age of the patients was 31.5 months, and Group 1 (30 months) had a significantly lower mean age than Group 2 (34 months) (P=0.019). There were no statistically significant differences regarding the pre- and postoperative acetabular indices. In Group 1, 27 (58%) out of 46 hips had AVN, whereas the rate of AVN was ten (30%) out of 30 hips in Group 2. Out of the 27 hips with AVN in Group 1, 12 were type 1, five were type 2, and ten were type 3. Out of the 10 hips with AVN in Group 2, seven were type 1, two were type 2, and one was type 4. There was a statistically significant difference between the groups regarding the rates of AVN, with Group 2 having better outcomes not only in comparison to the rate of all AVNs (P=0.031) but also in comparison to high-grade AVNs (P=0.042) (Grade 3 and Grade 4). Conclusion: Performing FSO with OR and PPO provides a significant decrease in the rate of AVN without altering acetabular development after surgery.
{"title":"A retrospective analysis of the effects of femoral shortening osteotomy on clinical and radiologic outcomes in open reduction and Pemberton pericapsular osteotomy for Tonnis type 4 dysplasia of the hip","authors":"M. Köse, M. Topal, S. Yılar, Muhammet Çağatay Engin, Ö. Yıldırım, Alperen Zeynel","doi":"10.28982/josam.7745","DOIUrl":"https://doi.org/10.28982/josam.7745","url":null,"abstract":"Background/Aim: Open reduction (OR) and Pemberton’s periacetabular osteotomy (PPO) are efficient and reliable methods for treating late-diagnosed developmental dysplasia of the hip. However, various studies have reported an avascular necrosis (AVN) rate of up to 80% with this technique, which is increased in Tönnis type 4 hips. In this study, we hypothesized that femoral shortening osteotomy (FSO) would reduce the rates of AVN by decreasing the post-reduction pressure on the femoral head.\u0000Methods: In this retrospective cohort study, we reviewed patients who had undergone OR and PPO between 2006 and 2016. Only hips with Tönnis type 4 dislocation were included. The subjects were divided into two groups: Group 1, who had undergone OR+PPO, and Group 2, who had undergone OR+PPO+FSO. The Kalamchi-MacEwen system was used for AVN classification. The groups were compared regarding the pre- and postoperative acetabular indices and the rate of AVN and other complications.\u0000Results: We included 76 hips of 50 patients who met the inclusion criteria in the study. Group 1 consisted of 46 hips of 32 patients, and Group 2 consisted of 30 hips of 18 patients. The mean age of the patients was 31.5 months, and Group 1 (30 months) had a significantly lower mean age than Group 2 (34 months) (P=0.019). There were no statistically significant differences regarding the pre- and postoperative acetabular indices. In Group 1, 27 (58%) out of 46 hips had AVN, whereas the rate of AVN was ten (30%) out of 30 hips in Group 2. Out of the 27 hips with AVN in Group 1, 12 were type 1, five were type 2, and ten were type 3. Out of the 10 hips with AVN in Group 2, seven were type 1, two were type 2, and one was type 4. There was a statistically significant difference between the groups regarding the rates of AVN, with Group 2 having better outcomes not only in comparison to the rate of all AVNs (P=0.031) but also in comparison to high-grade AVNs (P=0.042) (Grade 3 and Grade 4).\u0000Conclusion: Performing FSO with OR and PPO provides a significant decrease in the rate of AVN without altering acetabular development after surgery.","PeriodicalId":30878,"journal":{"name":"International Journal of Surgery and Medicine","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75459659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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