subjects (> 120% ideal body weight) randomised primarily to metformin, there was a substantial risk reduction for MI (39%, p=0.01) and all-cause mortality (36%, p=0.011). The blood pressure control part of the UKPDS, known as the Hypertension in Diabetes Study (HDS), demonstrated that tight blood pressure control over nine years (mean fall of 160/94 to 144/82 mmHg), with either atenolol or captopril, compared to a less tight blood pressure control group (mean fall of 161/94 to 154/87 mmHg) – a difference of 10/5 mmHg, sustained over the nine years – resulted in significant benefit. There was a reduction in overall risk of microvascular complications by 37% (p=0.0092), diabetes-related deaths by 32% (p=0.0046) but no significant effect was seen in all-cause mortality. After 6 years, 29% of the diabetic subjects required three or more drugs to achieve tight blood pressure control.
{"title":"The UK Prospective Diabetes Study (UKPDS): Its legacy for type 2 diabetes management","authors":"I. Campbell","doi":"10.3132/PCCJ.2009.012","DOIUrl":"https://doi.org/10.3132/PCCJ.2009.012","url":null,"abstract":"subjects (> 120% ideal body weight) randomised primarily to metformin, there was a substantial risk reduction for MI (39%, p=0.01) and all-cause mortality (36%, p=0.011). The blood pressure control part of the UKPDS, known as the Hypertension in Diabetes Study (HDS), demonstrated that tight blood pressure control over nine years (mean fall of 160/94 to 144/82 mmHg), with either atenolol or captopril, compared to a less tight blood pressure control group (mean fall of 161/94 to 154/87 mmHg) – a difference of 10/5 mmHg, sustained over the nine years – resulted in significant benefit. There was a reduction in overall risk of microvascular complications by 37% (p=0.0092), diabetes-related deaths by 32% (p=0.0046) but no significant effect was seen in all-cause mortality. After 6 years, 29% of the diabetic subjects required three or more drugs to achieve tight blood pressure control.","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126246556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GPs can, and should, manage obesity as part of reducing the risk of cardiovascular disease","authors":"S. Mayor","doi":"10.3132/pccj.2008.012","DOIUrl":"https://doi.org/10.3132/pccj.2008.012","url":null,"abstract":"","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126652598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The essentials of diet and supplements for improving cardiovascular health","authors":"J. O’Keefe","doi":"10.3132/PCCJ.2008.035","DOIUrl":"https://doi.org/10.3132/PCCJ.2008.035","url":null,"abstract":"","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129425987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving outcomes in cardiovascular disease: An Invest to Saveguide for practice based commissioners","authors":"M. Kearney, Hannah Chellaswamy","doi":"10.3132/PCCJ.2009.021","DOIUrl":"https://doi.org/10.3132/PCCJ.2009.021","url":null,"abstract":"","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130736236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of paediatric hypertension","authors":"A. Fuat","doi":"10.3132/PCCJ.2009.010","DOIUrl":"https://doi.org/10.3132/PCCJ.2009.010","url":null,"abstract":"","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122525324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"If at first you dont succeed, try, try again!","authors":"Michael X. Kirby","doi":"10.3132/PCCJ.2010.007","DOIUrl":"https://doi.org/10.3132/PCCJ.2010.007","url":null,"abstract":"","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124072795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A typical case of end-stage heart failure","authors":"A. Fuat","doi":"10.3132/PCCJ.2008.007","DOIUrl":"https://doi.org/10.3132/PCCJ.2008.007","url":null,"abstract":"","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123559622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aspirin in patients with and without diabetes","authors":"A. Begg","doi":"10.3132/PCCJ.2009.014","DOIUrl":"https://doi.org/10.3132/PCCJ.2009.014","url":null,"abstract":"","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116991438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
• Cigarette smoking • Serum lipid levels • Hypertension • Hyperglycaemia/insulin resistance • Excess body weight • Thrombotic risk10 D. Duhot, MD Societe Francaise de Medecine Generale, 141 avenue de Verdun 92130 Issy les Moulineaux, France E. McGregor, PhD Senior Editor, The Future Forum Secretariat, London, UK Diana Gorog Consultant Cardiologist, East & North Hertfordshire NHS Trust and Imperial College London C. Packard, DSc, FRSE Department of Pathological Biochemistry, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, UK *Corresponding author Email: d.duhot@sfmg.org Prim Care Cardiovasc J 2010; 3: 91-96 doi: 10.3132/pccj.2010.011
•吸烟•血脂水平•高血压•高血糖/胰岛素抵抗•体重超重•血栓形成风险10 D. Duhot，医学博士法国兴业医学总院，凡尔登大道141号，92130法国Issy les Moulineaux，法国E. McGregor博士，高级编辑，未来论坛秘书处，英国伦敦Diana Gorog顾问心脏病专家，赫特福德郡东部和北部NHS信托基金和伦敦帝国理工学院C. Packard, DSc, FRSE病理生物化学系格拉斯哥皇家医院，亚历山德拉游行，格拉斯哥，英国*通讯作者电子邮件:d.duhot@sfmg.org Prim Care cardiovascular J 2010;[3]: 91-96 doi: 10.3132/pccj.2010.011
{"title":"An international perspective on cardiovascular risk management: recommendations for high-risk patients","authors":"D. Duhot, E. Mcgregor, Diana A Gorog, C. Packard","doi":"10.3132/PCCJ.2010.011","DOIUrl":"https://doi.org/10.3132/PCCJ.2010.011","url":null,"abstract":"• Cigarette smoking • Serum lipid levels • Hypertension • Hyperglycaemia/insulin resistance • Excess body weight • Thrombotic risk10 D. Duhot, MD Societe Francaise de Medecine Generale, 141 avenue de Verdun 92130 Issy les Moulineaux, France E. McGregor, PhD Senior Editor, The Future Forum Secretariat, London, UK Diana Gorog Consultant Cardiologist, East & North Hertfordshire NHS Trust and Imperial College London C. Packard, DSc, FRSE Department of Pathological Biochemistry, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, UK *Corresponding author Email: d.duhot@sfmg.org Prim Care Cardiovasc J 2010; 3: 91-96 doi: 10.3132/pccj.2010.011","PeriodicalId":308856,"journal":{"name":"Primary Care Cardiovascular Journal (pccj)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125183836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：