Background and Purpose: The main purpose of our study was to observe the changes occuring on arterial walls due to experimental SAH model and to investigate the effects of valproic acid on the basilar artery and brain tissues to prevent these changes and vasospasm. Material and Method: We used 24 New Zeland rabbits. Animals were randomly divided into three groups as control (C), subarachnoidal hemorrhage (SAH) and valproic acid (VPA) groups. Cisterna magna puncture was done to all animals. SAH occured by giving non heparinised autologous blood except control group. 100 mg/kg of Valproic acid was given intra peritoneally to treatment group. All animals were sacrified after 48 hours. All experimental and surgical procedures were approved by İnönü University Animal Research Comittee. Results: Our expectation was the arterial lumen area of SAH group will be smaller than control group. After statistical calculations we found that our expectation was similiar with our findings that the smallest artery lumen was seen in SAH group and the largest artery lumen was seen in control group. These differences were statistically significant. Conclusion: Our findings showed that Valproic acid can prevent vasospasm by preventing arterial wall changes induced by SAH. It may be clinically beneficial at patients suffering from vasospasm due to SAH.
{"title":"Effect of Valproic Acid on Vasospasm at Experimental Subarachnoidal Hemorrhage Model","authors":"C. O. Cakir, A. Koçak","doi":"10.54306/sscd.2022.214","DOIUrl":"https://doi.org/10.54306/sscd.2022.214","url":null,"abstract":"Background and Purpose: The main purpose of our study was to observe the changes occuring on arterial walls due to experimental SAH model and to investigate the effects of valproic acid on the basilar artery and brain tissues to prevent these changes and vasospasm.\u0000Material and Method: We used 24 New Zeland rabbits. Animals were randomly divided into three groups as control (C), subarachnoidal hemorrhage (SAH) and valproic acid (VPA) groups. Cisterna magna puncture was done to all animals. SAH occured by giving non heparinised autologous blood except control group. 100 mg/kg of Valproic acid was given intra peritoneally to treatment group. All animals were sacrified after 48 hours. All experimental and surgical procedures were approved by İnönü University Animal Research Comittee.\u0000Results: Our expectation was the arterial lumen area of SAH group will be smaller than control group. After statistical calculations we found that our expectation was similiar with our findings that the smallest artery lumen was seen in SAH group and the largest artery lumen was seen in control group. These differences were statistically significant.\u0000Conclusion: Our findings showed that Valproic acid can prevent vasospasm by preventing arterial wall changes induced by SAH. It may be clinically beneficial at patients suffering from vasospasm due to SAH.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127337249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İ. Anık, M. İlbay, G. Ilbay, Mustafa YILMAZ, Bedrettin Özsoy, C. Erçin, S. Ceylan
The aim of this study is to evaluate macroscopic, histopathologic and immunohistochemical effects of topical cyclosporin administration on prevention of epineural scar formation in rats.This experimental study was performed in two groups, each consisting of ten rats. Sciatic nerve was opened bilaterally. Tibial and peroneal components were set apart with blunt dissection. Abrasion injury was achieved by repetitive rubbing over biceps femoris muscle. In the control group saline sucked cotton peds were administered over opened sciatic nerve region bilaterally, whereas cyclosporin sucked peds were administered in the second group for five minutes duration. Eight weeks after surgery both groups were sacrificed and nerve complexes were evaluated microscopically, histopathologically and immunohistochemically. No side effects were observed after 5 minutes single dose topical cyclosporine administration in our study. Cutaneous, muscular and deep fascial repairment were almost completed according to Petersen’s numerical grading system (p<0.05). Nerve adherence was significantly decreased (p<0.001) in the ones treated with cyclosporin than the control group. FGF expression was demonstrated and individual evaluations of the control and the study groups immunhistochemically. The ratio of fibroblast/fibrosit number showed that both groups results were parallel. Single dose topical cyclosporin administration is shown to be successfull in preventing epineural scar formation after peripheric nerve neurolysis.
{"title":"Effects of Topical Cyclosporin A Application on Preventing Epineural Scar Formation in Rats: Experimental Study","authors":"İ. Anık, M. İlbay, G. Ilbay, Mustafa YILMAZ, Bedrettin Özsoy, C. Erçin, S. Ceylan","doi":"10.54306/sscd.2022.217","DOIUrl":"https://doi.org/10.54306/sscd.2022.217","url":null,"abstract":"The aim of this study is to evaluate macroscopic, histopathologic and immunohistochemical effects of topical cyclosporin administration on prevention of epineural scar formation in rats.This experimental study was performed in two groups, each consisting of ten rats. Sciatic nerve was opened bilaterally. Tibial and peroneal components were set apart with blunt dissection. Abrasion injury was achieved by repetitive rubbing over biceps femoris muscle. In the control group saline sucked cotton peds were administered over opened sciatic nerve region bilaterally, whereas cyclosporin sucked peds were administered in the second group for five minutes duration. Eight weeks after surgery both groups were sacrificed and nerve complexes were evaluated microscopically, histopathologically and immunohistochemically. No side effects were observed after 5 minutes single dose topical cyclosporine administration in our study. Cutaneous, muscular and deep fascial repairment were almost completed according to Petersen’s numerical grading system (p<0.05). Nerve adherence was significantly decreased (p<0.001) in the ones treated with cyclosporin than the control group. FGF expression was demonstrated and individual evaluations of the control and the study groups immunhistochemically. The ratio of fibroblast/fibrosit number showed that both groups results were parallel. Single dose topical cyclosporin administration is shown to be successfull in preventing epineural scar formation after peripheric nerve neurolysis.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114988098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tugay Atalay, Ebru Güzel, K. Oktay, A. Demirci, Cengiz Gölçek, Hakan Ak, Aslan Güzel
Amaç: Kalvariyum dayanaklı bir yapı olarak beynimizi korumada primer öneme sahiptir. Kalvariyumda kötü huylu ya da iyi huylu tümoral oluşumlar ile birlikte çeşitli metabolik tümör benzeri değişikler görülebilmektedir. Bu makalede bir sağlık merkezinde iyi huylu kalvariyal lezyonlar nedeni ile ameliyat edilen olgular irdelenmektedir. Materyal Metod: Çalışma retrospektif karakterde olup hastaların yaş cinsiyet gibi demografik verileri yanında başvuru şikayeti, kitlenin yerleşim yeri, geçirilmiş ameliyat öyküsü, radyolojik görüntüleri, lezyon çapı, patolojik tanı, ameliyat şekli, dural etkilenim, nüks edip etmediği, komplikasyon gelişimi ve takip süresi not edilmiştir. Sonuçlar: Çalışmaya toplamda 13 hasta dahil olmuştur. Bu hastaların 12 tanesi erişkin yaşta hasta iken sadece bir tanesinin çocuk hasta olduğu tespit edildi. 9 hastanın erkek cinsiyette olduğu belirlendi. En sık başvuru şikayeti kafada ağrılı şişlik idi. En sık iki tanı fibröz diplazi ve osteom olarak belirlendi. Bir hastada intraserebral komplikasyon gelişimi oldu. Hiçbir hastada nüks görülmedi.
{"title":"İyi Huylu Kalvaryal Lezyonlar: Klinik Deneyim","authors":"Tugay Atalay, Ebru Güzel, K. Oktay, A. Demirci, Cengiz Gölçek, Hakan Ak, Aslan Güzel","doi":"10.54306/sscd.2022.219","DOIUrl":"https://doi.org/10.54306/sscd.2022.219","url":null,"abstract":"Amaç: Kalvariyum dayanaklı bir yapı olarak beynimizi korumada primer öneme sahiptir. Kalvariyumda kötü huylu ya da iyi huylu tümoral oluşumlar ile birlikte çeşitli metabolik tümör benzeri değişikler görülebilmektedir. Bu makalede bir sağlık merkezinde iyi huylu kalvariyal lezyonlar nedeni ile ameliyat edilen olgular irdelenmektedir.\u0000Materyal Metod: Çalışma retrospektif karakterde olup hastaların yaş cinsiyet gibi demografik verileri yanında başvuru şikayeti, kitlenin yerleşim yeri, geçirilmiş ameliyat öyküsü, radyolojik görüntüleri, lezyon çapı, patolojik tanı, ameliyat şekli, dural etkilenim, nüks edip etmediği, komplikasyon gelişimi ve takip süresi not edilmiştir.\u0000Sonuçlar: Çalışmaya toplamda 13 hasta dahil olmuştur. Bu hastaların 12 tanesi erişkin yaşta hasta iken sadece bir tanesinin çocuk hasta olduğu tespit edildi. 9 hastanın erkek cinsiyette olduğu belirlendi. En sık başvuru şikayeti kafada ağrılı şişlik idi. En sık iki tanı fibröz diplazi ve osteom olarak belirlendi. Bir hastada intraserebral komplikasyon gelişimi oldu. Hiçbir hastada nüks görülmedi.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123728017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaç: Normal Basınçlı Hidrosefali (NBH) kafaiçi basınç artışı olmaksızın ventrikül genişlemesi gösteren ve “yürüyüş bozukluğu, demans ve inkontinans” kardinal bulguları ile ortaya çıkan bir sendrom olarak tarif edilmiştir. Bu klasik triad beyin omurilik sıvısı (BOS) tahliye işlemleri ile düzelme gösterir. Ne var ki tanımının üzerinden yarım asır geçmesine rağmen hastalığın semptomları, fizyopatolojisi, tanı ve tedavi kriterleri, insidans ve prevalansında belirsizlik sürmektedir. Bu çalışmada ventrikül genişlemesinin radyolojik ve klinik özellikleri ile Ventriküloperitonel “Shunt” (VPS) ameliyatına iyi yanıt veren ve vermeyen hastaların sonuçlarının değerlendirilmesi amaçlandı. Gereç ve Yöntem: 27 olgudan oluşan bu Normal Basınçlı Hidrosefali (NBH) serisinde ameliyat öncesinde ve 6 ay sonrasında ayrıntılı nörolojik muayene yanında Normal Basınçlı Hidrosefali Derecelendirme Skalası (NBHDS), nöropsikoloji testleri (NPT) ve bilgisayarlı beyin tomografisi (BT), kranyal manyetik rezonans görüntüleme (MRG) yapıldı. Radyolojik olarak mevcut ventrikül genişlemesinin özellikleri ve eşlik eden MRG bulguları değerlendirildi. Bütün olgular ayarlanabilir VPS (Medtronic Strata®) ile tedavi edildiler ve ameliyat sonrasında en az 6 ay takip edildiler. Bulgular: NBHDS göre 27 hastanın 22 si VPS ameliyatına iyi yanıt verdi, 5 i yanıtsızdı. Ameliyat öncesi ventrikülleri uniform genişleyen hastaların ventriküllerin sadece temporooksipital bölümü geniş olan hastalar karşılaştırıldığında VPS yanıtı ile istatistiksel anlamlı ilişki saptanmadı (p=0.768, p=0.623). Sonuç: Bu çalışmada VPS cevaplı ve cevapsız hastalar ile ventriküllerin büyüme formu arasında bir ilişki olmadığı gösterildi.
{"title":"Ventrikül Büyüme Paterni Ventriküloperitoneal Şant Cevabını Preop Belirleyebilir Mi?","authors":"Ömer Özdemir, Orhan Barlas","doi":"10.54306/sscd.2022.211","DOIUrl":"https://doi.org/10.54306/sscd.2022.211","url":null,"abstract":"Amaç: Normal Basınçlı Hidrosefali (NBH) kafaiçi basınç artışı olmaksızın ventrikül genişlemesi gösteren ve “yürüyüş bozukluğu, demans ve inkontinans” kardinal bulguları ile ortaya çıkan bir sendrom olarak tarif edilmiştir. Bu klasik triad beyin omurilik sıvısı (BOS) tahliye işlemleri ile düzelme gösterir. Ne var ki tanımının üzerinden yarım asır geçmesine rağmen hastalığın semptomları, fizyopatolojisi, tanı ve tedavi kriterleri, insidans ve prevalansında belirsizlik sürmektedir. Bu çalışmada ventrikül genişlemesinin radyolojik ve klinik özellikleri ile Ventriküloperitonel “Shunt” (VPS) ameliyatına iyi yanıt veren ve vermeyen hastaların sonuçlarının değerlendirilmesi amaçlandı. Gereç ve Yöntem: 27 olgudan oluşan bu Normal Basınçlı Hidrosefali (NBH) serisinde ameliyat öncesinde ve 6 ay sonrasında ayrıntılı nörolojik muayene yanında Normal Basınçlı Hidrosefali Derecelendirme Skalası (NBHDS), nöropsikoloji testleri (NPT) ve bilgisayarlı beyin tomografisi (BT), kranyal manyetik rezonans görüntüleme (MRG) yapıldı. Radyolojik olarak mevcut ventrikül genişlemesinin özellikleri ve eşlik eden MRG bulguları değerlendirildi. Bütün olgular ayarlanabilir VPS (Medtronic Strata®) ile tedavi edildiler ve ameliyat sonrasında en az 6 ay takip edildiler. Bulgular: NBHDS göre 27 hastanın 22 si VPS ameliyatına iyi yanıt verdi, 5 i yanıtsızdı. Ameliyat öncesi ventrikülleri uniform genişleyen hastaların ventriküllerin sadece temporooksipital bölümü geniş olan hastalar karşılaştırıldığında VPS yanıtı ile istatistiksel anlamlı ilişki saptanmadı (p=0.768, p=0.623). Sonuç: Bu çalışmada VPS cevaplı ve cevapsız hastalar ile ventriküllerin büyüme formu arasında bir ilişki olmadığı gösterildi.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121477519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Gliosarcoma is a rare central nervous system tumor and shows genetic, clinical, and prognostic similarities Glioblastoma multiforme. It presents with progressive neurological deficits such as increased intracranial pressure, seizures, and hemiparesis. Case Report: We report an 81-year-old female patient was consulted from internal medicine clinic with severe headache and weakness on her right side. Conclusion: Gliosarcoma may be accompanied by intra-tumor bleeding. It is not possible to predict when the bleeding would occur. Hematoma may mask tumoral lesion.
{"title":"Unexpected Intratumoral Bleeding during Surgery Decision: Gliosarcoma","authors":"Hakan Ak, Ihsan Canbek","doi":"10.54306/sscd.2022.199","DOIUrl":"https://doi.org/10.54306/sscd.2022.199","url":null,"abstract":"Introduction: Gliosarcoma is a rare central nervous system tumor and shows genetic, clinical, and prognostic similarities Glioblastoma multiforme. It presents with progressive neurological deficits such as increased intracranial pressure, seizures, and hemiparesis.\u0000Case Report: We report an 81-year-old female patient was consulted from internal medicine clinic with severe headache and weakness on her right side.\u0000Conclusion: Gliosarcoma may be accompanied by intra-tumor bleeding. It is not possible to predict when the bleeding would occur. Hematoma may mask tumoral lesion.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126361601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osman Boyalı, Ömer Özdemir, Furkan Diren, Fatih Cesur, Ercan Çetin, Nilifer Taş, Saygın Uçar, Mourat Chasan, Serdar Kabataş, Erdinç Civelek
Nöroşirürjide beyin omurilik sıvısı (BOS) fistülü önemli bir komplikasyondur. Hemopatch®’in (Sealing Hemostat – Baxter Healthcare SA, Avusturya) fibrin yapıştırıcı (Tisseel®, Baxter Healthcare SA, İsviçre) ile birlikte kraniyal cerrahide kullanımı ile birlikte literatür değerlendirmesi yapılmıştır. İntrakraniyal kitle nedeniyle ameliyat edilen ve dural kapanma aşamasında fibrin yapıştırıcı ile birlikte Hemopatch® kullanılan 4 hastanın ameliyat sonrası erken ve geç dönem sonuçları irdelendi. Hastaların yaş ortalaması 62.25 ± 10.49 yıl ve ortalama takip süreleri 16.25 ± 3.27 hafta idi. Fibrin yapıştırıcılı Hemopatch® kullanılan hastaların tamamı kraniyal cerrahi (%75 pterional kraniyotomi, %25 retrosigmoid kraniyotomi idi) geçiren hastalardan oluşmaktaydı. Takip sonrasında geniş dura invazyonuna bağlı dural tabakanın tamamen çıkarılarak faysa ve xenogreft ile duraplasti yapılarak Hemopatch® uygulanan 1 hastada (Hasta 1) post operatif erken dönemde Beyin Omurilik Sıvısı (BOS) kaçağı oldu. Sonuç olarak, öncelikle Hemopatch®’in fibrin yapıştırıcılı kraniyal cerrahide dural örtücü olarak kullanılmasının uygulanabilirliğini ve güvenliğini ortaya koyduk.
{"title":"Nöroşirürjide Yeni Nesil Dural Kapatıcı Hemopatch®; Klinik Deneyimimiz","authors":"Osman Boyalı, Ömer Özdemir, Furkan Diren, Fatih Cesur, Ercan Çetin, Nilifer Taş, Saygın Uçar, Mourat Chasan, Serdar Kabataş, Erdinç Civelek","doi":"10.54306/sscd.2022.212","DOIUrl":"https://doi.org/10.54306/sscd.2022.212","url":null,"abstract":"Nöroşirürjide beyin omurilik sıvısı (BOS) fistülü önemli bir komplikasyondur. Hemopatch®’in (Sealing Hemostat – Baxter Healthcare SA, Avusturya) fibrin yapıştırıcı (Tisseel®, Baxter Healthcare SA, İsviçre) ile birlikte kraniyal cerrahide kullanımı ile birlikte literatür değerlendirmesi yapılmıştır. İntrakraniyal kitle nedeniyle ameliyat edilen ve dural kapanma aşamasında fibrin yapıştırıcı ile birlikte Hemopatch® kullanılan 4 hastanın ameliyat sonrası erken ve geç dönem sonuçları irdelendi. Hastaların yaş ortalaması 62.25 ± 10.49 yıl ve ortalama takip süreleri 16.25 ± 3.27 hafta idi. Fibrin yapıştırıcılı Hemopatch® kullanılan hastaların tamamı kraniyal cerrahi (%75 pterional kraniyotomi, %25 retrosigmoid kraniyotomi idi) geçiren hastalardan oluşmaktaydı. Takip sonrasında geniş dura invazyonuna bağlı dural tabakanın tamamen çıkarılarak faysa ve xenogreft ile duraplasti yapılarak Hemopatch® uygulanan 1 hastada (Hasta 1) post operatif erken dönemde Beyin Omurilik Sıvısı (BOS) kaçağı oldu. Sonuç olarak, öncelikle Hemopatch®’in fibrin yapıştırıcılı kraniyal cerrahide dural örtücü olarak kullanılmasının uygulanabilirliğini ve güvenliğini ortaya koyduk.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123394532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Metastatic brain tumors are the most commonly seen intracranial lesion in adults and an important cause of morbidity and mortality in patients with cancer. This study aimed to evaluate the postoperative mortality, morbidity, and survival rates of patients who underwent surgery in our clinic for metastatic brain tumorsMethod: Clinical data of 131 patients, including age, sex, symptoms, localization, primer site, surgical methods, resection, complications and recurrence were collected.Results: Fifty patients (38.1%) were female, and 81 (61.8%) patients were male. The average age of the patients was 54,9. The most common reason for hospital admission was headache (68.7%). Lesions were detected in the cerebral hemisphere in 108 (82.4%) patients and the posterior fossa in 23 (17.5%) patients, and 16 (12.2%) patients had multiple lesions. All patients (n=131) underwent surgery with neuronavigation. Total resection was performed in 25 (19%) patients, gross total resection in 83 (63.3%), subtotal resection in 18 (13.7%), and biopsy in 5 (3.8%). The most commonly seen tumor originated from the lungs (n=63, 48%), according to the histopathological examination. The mean overall survival was 5.3 (range, 1–36) months during the follow-up period. Twelve (9.1%) patients had recurrence and underwent surgery again.Conclusion: Multidisciplinary treatment methods are used in the treatment of metastatic brain tumors. Effective surgical intervention to eliminate peritumoral edema and increased intracranial pressure improves postoperative survival rates. In addition, post-surgical whole-brain radiotherapy reduces recurrence and improves survival.
{"title":"Surgical Management and Postoperative Outcome in patients with Brain Metastases: Our Surgical Experience","authors":"Adem Doğan, M. Durmaz, İ. Gezgin, A. Kaplan","doi":"10.54306/sscd.2022.209","DOIUrl":"https://doi.org/10.54306/sscd.2022.209","url":null,"abstract":"Aims: Metastatic brain tumors are the most commonly seen intracranial lesion in adults and an important cause of morbidity and mortality in patients with cancer. This study aimed to evaluate the postoperative mortality, morbidity, and survival rates of patients who underwent surgery in our clinic for metastatic brain tumorsMethod: Clinical data of 131 patients, including age, sex, symptoms, localization, primer site, surgical methods, resection, complications and recurrence were collected.Results: Fifty patients (38.1%) were female, and 81 (61.8%) patients were male. The average age of the patients was 54,9. The most common reason for hospital admission was headache (68.7%). Lesions were detected in the cerebral hemisphere in 108 (82.4%) patients and the posterior fossa in 23 (17.5%) patients, and 16 (12.2%) patients had multiple lesions. All patients (n=131) underwent surgery with neuronavigation. Total resection was performed in 25 (19%) patients, gross total resection in 83 (63.3%), subtotal resection in 18 (13.7%), and biopsy in 5 (3.8%). The most commonly seen tumor originated from the lungs (n=63, 48%), according to the histopathological examination. The mean overall survival was 5.3 (range, 1–36) months during the follow-up period. Twelve (9.1%) patients had recurrence and underwent surgery again.Conclusion: Multidisciplinary treatment methods are used in the treatment of metastatic brain tumors. Effective surgical intervention to eliminate peritumoral edema and increased intracranial pressure improves postoperative survival rates. In addition, post-surgical whole-brain radiotherapy reduces recurrence and improves survival.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123779396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We would like to inform and guide other hand surgery physicians by sharing the results of a patient with ulnar nerve compression due to hemosiderin accumulation due to hemophilia. We operated a hemophilia patient who applied late and had ulnar nerve compression and we achieved a successful result. In this publication, the patient we operated on was presented as a case report and discussed in the light of literature.
{"title":"The Treatment of Advanced Cubital Tunnel Syndrome in a Patient with Hemophilia and Its Postoperative Results","authors":"E. Kütük, W. Msangi, Eren Cansü","doi":"10.54306/sscd.2022.203","DOIUrl":"https://doi.org/10.54306/sscd.2022.203","url":null,"abstract":"We would like to inform and guide other hand surgery physicians by sharing the results of a patient with ulnar nerve compression due to hemosiderin accumulation due to hemophilia. We operated a hemophilia patient who applied late and had ulnar nerve compression and we achieved a successful result. In this publication, the patient we operated on was presented as a case report and discussed in the light of literature.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128313662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erek Öztürk, Eyüp Can Savrunlu, Murat Kahraman, Y. Navruz, Necati Kaplan, Selçuk Özdoğan, E. Civelek, S. Kabataş
Background: The aim of this study was to evaluate the correlation between serum superoxide dismutase (SOD) enzyme levels and lumbar degenerative spinal diseases (LDSD).Materials and Methods: Ninety-four patients with LDSD and 64 patients without LDSD were investigated. Human SOD ELISA kits were used to measure the amount of enzymes in the samples. Serum SOD enzyme levels were determined by Student-t and Mann Whitney-U tests to determine differences between groups.Results: The patient group was classified according to the characteristics of the disease, clinical symptoms, Visual Analog Scale (VAS) values, and Oswestry Disability Index (ODI) scores. Along with these parameters, serum SOD levels were evaluated statistically. There was no statistically significant difference in serum SOD levels in both groups. However, serum SOD levels were relatively lower in the patient group (p>0.05).Conclusions: Our study could supply objective value for future researchers investigating specific lumbar diseases, should they attempt to find a serum biomarker for the disease. More studies with an increasing number of patients are needed to support the results of our study. Doing so may offer more specific insights on the mechanisms of LDSD and its features, which could contribute to the literature.
{"title":"Evaluation of Serum Superoxide Dismutase Levels in Lumbar Degenerative Spinal Diseases: A Prospective Meta-analysis","authors":"Erek Öztürk, Eyüp Can Savrunlu, Murat Kahraman, Y. Navruz, Necati Kaplan, Selçuk Özdoğan, E. Civelek, S. Kabataş","doi":"10.54306/sscd.2022.210","DOIUrl":"https://doi.org/10.54306/sscd.2022.210","url":null,"abstract":"Background: The aim of this study was to evaluate the correlation between serum superoxide dismutase (SOD) enzyme levels and lumbar degenerative spinal diseases (LDSD).Materials and Methods: Ninety-four patients with LDSD and 64 patients without LDSD were investigated. Human SOD ELISA kits were used to measure the amount of enzymes in the samples. Serum SOD enzyme levels were determined by Student-t and Mann Whitney-U tests to determine differences between groups.Results: The patient group was classified according to the characteristics of the disease, clinical symptoms, Visual Analog Scale (VAS) values, and Oswestry Disability Index (ODI) scores. Along with these parameters, serum SOD levels were evaluated statistically. There was no statistically significant difference in serum SOD levels in both groups. However, serum SOD levels were relatively lower in the patient group (p>0.05).Conclusions: Our study could supply objective value for future researchers investigating specific lumbar diseases, should they attempt to find a serum biomarker for the disease. More studies with an increasing number of patients are needed to support the results of our study. Doing so may offer more specific insights on the mechanisms of LDSD and its features, which could contribute to the literature.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114712092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Hemilaminectomy can be used to treat different space-occupying lesions, whether intradural, extramedullary, intramedullary, or extradural. In this study, We have investigated to illuminate the role of hemilaminectomy in benign spinal cord tumors, which occupy the spinal canal. Materials and Methods: 15 patients with spinal tumors who were operated on with hemilaminectomy were included in the evaluation. The hemilaminectomy method was chosen based on the size, laterality, number of segments involved, and possible pathologies. The demographics of the subjects, as well as their operating reports, histological results, pre- and postoperative images, and follow-up information, were examined. Frankel grade classification was used to assess the neurological status on admission and during follow-up. Results: The mean age of the patients was 48.4 years. Nine of the patients were male and 6 were female. According to tumor localization, 3 of them were cervical, 7 were thoracic, and 5 were lumbar. 4 of them were meningiomas, 6 were ependymomas, and 5 were schwannomas. One patient was worse than the pre-operative, and the post-operative grades of the remaining 11 patients were similar to the pre-operative grades. Post-operative imaging showed that gross-total resection was achieved in all patients. Conclusion: If used correctly and with a reasonable learning curve, limited unilateral hemilaminectomy can offer enough access to the dural sac, allowing for safe resection of nearly all spinal intradural and extradural lesions. Because it takes less time to operate than a standard laminectomy, it is better for older or high-risk patients.
{"title":"The Role of Unilateral Hemilaminectomy in Benign Intradural Spinal Tumor Surgery","authors":"Reha Can Köylü, M. Etli, C. Yaltırık","doi":"10.54306/sscd.2022.206","DOIUrl":"https://doi.org/10.54306/sscd.2022.206","url":null,"abstract":"Objective: Hemilaminectomy can be used to treat different space-occupying lesions, whether intradural, extramedullary, intramedullary, or extradural. In this study, We have investigated to illuminate the role of hemilaminectomy in benign spinal cord tumors, which occupy the spinal canal.\u0000Materials and Methods: 15 patients with spinal tumors who were operated on with hemilaminectomy were included in the evaluation. The hemilaminectomy method was chosen based on the size, laterality, number of segments involved, and possible pathologies. The demographics of the subjects, as well as their operating reports, histological results, pre- and postoperative images, and follow-up information, were examined. Frankel grade classification was used to assess the neurological status on admission and during follow-up.\u0000Results: The mean age of the patients was 48.4 years. Nine of the patients were male and 6 were female. According to tumor localization, 3 of them were cervical, 7 were thoracic, and 5 were lumbar. 4 of them were meningiomas, 6 were ependymomas, and 5 were schwannomas. One patient was worse than the pre-operative, and the post-operative grades of the remaining 11 patients were similar to the pre-operative grades. Post-operative imaging showed that gross-total resection was achieved in all patients.\u0000Conclusion: If used correctly and with a reasonable learning curve, limited unilateral hemilaminectomy can offer enough access to the dural sac, allowing for safe resection of nearly all spinal intradural and extradural lesions. Because it takes less time to operate than a standard laminectomy, it is better for older or high-risk patients.","PeriodicalId":309697,"journal":{"name":"Sinir Sistemi Cerrahisi Dergisi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125217516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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