{"title":"Bone metastases of prostate cancer: PSMA PET versus bone scan","authors":"I. Sarikaya","doi":"10.25259/asjo_4_2023","DOIUrl":"https://doi.org/10.25259/asjo_4_2023","url":null,"abstract":"","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43493380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To analyze the literature data and research status of immunotherapy for the treatment of diffuse large B-cell lymphoma since the establishment of the Web of Science (WOS) core database. The WOS core database was searched for literature related to immunotherapy for diffuse large B-cell lymphoma, and the included literature was formatted, cleaned, node merged, and analyzed using CiteSpace software. Based on the parameters set, the included literature was analyzed for trends in publications, author publications and inter-author collaborations, national publications, global institutional publications and inter-institutional collaborations, citations, keyword co-occurrence, keyword emergence, and keyword clustering. The final visual knowledge map was created. A total of 370 articles were selected for inclusion. The highest number of annual publications was in 2021. Four individuals, Marconato Laura; Ansell, Stephen M; Xiao Min; and Aresu Luca, were the most published scholars. The United States with 152 publications was the country with the highest number of publications. Benjamin J is the most cited scholar in this field. The top three most cited keywords were “expression,” “diffuse large b-cell lymphoma,” and “rituximab.” “Bone marrow transplantation” was the first and longest-running keyword. “Cancer immunotherapy,” “resistance,” and “cytokine release syndrome” are still hot topics. The keyword clusters “pd-l1,” “antibody-based,” “immunotherapy,” and “cd19” were the main clusters studied. After visualization and analysis, the recent research and hot trends in the field of immunotherapy for diffuse large B-cell lymphoma were reviewed using knowledge mapping and further presented in a visualized form, providing a reference for further development of related research in the future.
分析Web of Science (WOS)核心数据库建立以来免疫疗法治疗弥漫性大b细胞淋巴瘤的文献资料及研究现状。在WOS核心数据库中检索与弥漫性大b细胞淋巴瘤免疫治疗相关的文献，使用CiteSpace软件对纳入的文献进行格式化、清理、节点合并和分析。基于设置的参数，分析纳入文献的发表趋势、作者发表趋势和作者间合作趋势、国家发表趋势、全球机构发表趋势和机构间合作趋势、被引趋势、关键词共现趋势、关键词出现趋势和关键词聚类趋势。最终的可视化知识图谱创建完成。共有370篇文章入选。年度出版物数量最多的年份是2021年。四个人，Marconato Laura;斯蒂芬·M·安塞尔;肖最小;和阿雷苏·卢卡，是发表论文最多的学者。美国发表了152篇论文，是发表论文最多的国家。本杰明·J是这个领域被引用次数最多的学者。被引用最多的三个关键词是“表达”、“弥漫性大b细胞淋巴瘤”和“利妥昔单抗”。“骨髓移植”是第一个也是持续时间最长的关键词。“癌症免疫治疗”、“耐药性”和“细胞因子释放综合征”仍然是热门话题。关键词簇“pd-l1”、“基于抗体”、“免疫治疗”和“cd19”是研究的主要簇。通过可视化分析，利用知识图谱对弥漫性大b细胞淋巴瘤免疫治疗领域的最新研究和热点趋势进行综述，并进一步以可视化的形式呈现，为今后相关研究的进一步开展提供参考。
{"title":"A bibliometric analysis of CiteSpace software-based immunotherapy for the treatment of diffuse large B-cell lymphoma","authors":"Weichen Si","doi":"10.25259/asjo_1_2023","DOIUrl":"https://doi.org/10.25259/asjo_1_2023","url":null,"abstract":"\u0000\u0000To analyze the literature data and research status of immunotherapy for the treatment of diffuse large B-cell lymphoma since the establishment of the Web of Science (WOS) core database.\u0000\u0000\u0000\u0000The WOS core database was searched for literature related to immunotherapy for diffuse large B-cell lymphoma, and the included literature was formatted, cleaned, node merged, and analyzed using CiteSpace software. Based on the parameters set, the included literature was analyzed for trends in publications, author publications and inter-author collaborations, national publications, global institutional publications and inter-institutional collaborations, citations, keyword co-occurrence, keyword emergence, and keyword clustering. The final visual knowledge map was created.\u0000\u0000\u0000\u0000A total of 370 articles were selected for inclusion. The highest number of annual publications was in 2021. Four individuals, Marconato Laura; Ansell, Stephen M; Xiao Min; and Aresu Luca, were the most published scholars. The United States with 152 publications was the country with the highest number of publications. Benjamin J is the most cited scholar in this field. The top three most cited keywords were “expression,” “diffuse large b-cell lymphoma,” and “rituximab.” “Bone marrow transplantation” was the first and longest-running keyword. “Cancer immunotherapy,” “resistance,” and “cytokine release syndrome” are still hot topics. The keyword clusters “pd-l1,” “antibody-based,” “immunotherapy,” and “cd19” were the main clusters studied.\u0000\u0000\u0000\u0000After visualization and analysis, the recent research and hot trends in the field of immunotherapy for diffuse large B-cell lymphoma were reviewed using knowledge mapping and further presented in a visualized form, providing a reference for further development of related research in the future.\u0000","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44939678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01Epub Date: 2023-01-24DOI: 10.1057/s41280-022-00260-0
Eleanor Myerson
In this article I consider medieval blood imagery in the paintings, films and journals of Derek Jarman, focusing on works made between 1989-1993. Taking a transhistorical comparative approach, I analyse Jarman's images alongside his medieval sources, primarily Julian of Norwich's Revelations and Gerard of Cremona's translation of Ibn Sīnā's (Avicenna's) al-Qa'n ū n fī al-tibb (Canon of Medicine). In addition, I find my own commonalities between Jarman and the medieval, for example, juxtaposing his Queer series of paintings with MS Egerton 1821. Critics have explored the medieval as a site of historical precedent for the stigmatisation of disease, providing a reservoir of images of leprosy and plague which inform the discourse of AIDS as immoral pollution. However I follow Jarman's lead in seeking new avenues through the medieval in relation to the AIDS crisis. Refusing to accept the discourses which cast his HIV+ blood as the ultimate symbol of pollution and death, Jarman mobilised the aesthetics and imagery of medieval affective devotion as a powerful alternative. Through the deployment of these traditions, HIV+ blood becomes holy blood, the source of salvation, desire, community and healing.
在这篇文章中，我探讨了德里克-贾曼的绘画、电影和日记中的中世纪血腥图像，重点是 1989-1993 年间的作品。我采用一种跨历史的比较方法，将贾曼的图像与他的中世纪资料（主要是诺威奇的朱利安的《启示录》和克雷莫纳的杰拉德对伊本-西纳（阿维森纳）的《医典》（al-Qa'n ū n fī al-tibb）的翻译）一起进行分析。此外，我还发现了贾曼与中世纪之间的共通之处，例如，将他的 "同性恋者"（Queer）系列画作与《埃格顿1821》（MS Egerton 1821）并列。评论家们将中世纪作为疾病污名化的历史先例，提供了麻风病和瘟疫的形象库，为艾滋病作为不道德污染的论述提供了依据。然而，我跟随贾曼的脚步，通过中世纪寻求与艾滋病危机相关的新途径。贾曼拒绝接受将其艾滋病毒携带者的血液作为污染和死亡的终极象征的论述，他调动了中世纪情感奉献的美学和意象作为一种强有力的替代。通过对这些传统的运用，HIV+血液变成了圣血，成为救赎、欲望、群体和治愈的源泉。
{"title":"Derek Jarman's medieval blood: Queer devotion, affective medicine, and the AIDS Crisis.","authors":"Eleanor Myerson","doi":"10.1057/s41280-022-00260-0","DOIUrl":"10.1057/s41280-022-00260-0","url":null,"abstract":"<p><p>In this article I consider medieval blood imagery in the paintings, films and journals of Derek Jarman, focusing on works made between 1989-1993. Taking a transhistorical comparative approach, I analyse Jarman's images alongside his medieval sources, primarily Julian of Norwich's Revelations and Gerard of Cremona's translation of Ibn Sīnā's (Avicenna's) al-Qa'n ū n fī al-tibb (Canon of Medicine). In addition, I find my own commonalities between Jarman and the medieval, for example, juxtaposing his Queer series of paintings with MS Egerton 1821. Critics have explored the medieval as a site of historical precedent for the stigmatisation of disease, providing a reservoir of images of leprosy and plague which inform the discourse of AIDS as immoral pollution. However I follow Jarman's lead in seeking new avenues through the medieval in relation to the AIDS crisis. Refusing to accept the discourses which cast his HIV+ blood as the ultimate symbol of pollution and death, Jarman mobilised the aesthetics and imagery of medieval affective devotion as a powerful alternative. Through the deployment of these traditions, HIV+ blood becomes holy blood, the source of salvation, desire, community and healing.</p>","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":"02 1","pages":"61-88"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80103753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhanupriya Singh, R. Yadav, T. Kumar, Sandeep Kawlra
Objective Magnetic resonance spectroscopy (MRS) has emerged as a technique due to its ability to characterize the metabolite constituent of any lesion. We have evaluated magnetic resonance (MR) spectral patterns in different neoplastic brain lesions, using the ability of MRS in grading of gliomas. MRS also helps in differentiating between high-grade glioma and metastases. Method A retrospective observational study in histologically confirmed cases of brain neoplasms in which MRS was performed as a part of preoperative MR imaging. The pattern of metabolite peak was observed and means with standard deviation of different metabolite ratios (choline/creatine, choline/N-acetylaspartate [NAA], NAA/creatine) were calculated for different tumors. Analysis was done to see statistically significant differences in metabolite ratios of different grades of gliomas and to differentiate high-grade gliomas from metastases. Result A total of 61 cases with brain tumor were included in the study. Of which, 20 cases were of gliomas, 11 metastases, 9 meningiomas, 4 dysembryoplastic neuroepithelial tumors, 6 pituitary macroadenomas, 4 trigeminal schwannomas, 3 craniopharyngiomas, 2 acoustic schwannomas, and 2 medulloblastomas. Statistically significant differences in ratios of metabolite peaks were noted between different grades of gliomas and for high-grade glioma versus metastases. Conclusion MRS compliments the MR imaging and stands out as problem-solving method to distinguish neoplastic lesions in selected cases and also has a role in grading of gliomas and in differentiation of types of malignancies.
{"title":"Revisiting Concepts of Magnetic Resonance Spectroscopy in the Evaluation of Brain Lesions: An Institutional Experience","authors":"Bhanupriya Singh, R. Yadav, T. Kumar, Sandeep Kawlra","doi":"10.1055/s-0042-1750709","DOIUrl":"https://doi.org/10.1055/s-0042-1750709","url":null,"abstract":"\u0000 Objective Magnetic resonance spectroscopy (MRS) has emerged as a technique due to its ability to characterize the metabolite constituent of any lesion. We have evaluated magnetic resonance (MR) spectral patterns in different neoplastic brain lesions, using the ability of MRS in grading of gliomas. MRS also helps in differentiating between high-grade glioma and metastases.\u0000 Method A retrospective observational study in histologically confirmed cases of brain neoplasms in which MRS was performed as a part of preoperative MR imaging. The pattern of metabolite peak was observed and means with standard deviation of different metabolite ratios (choline/creatine, choline/N-acetylaspartate [NAA], NAA/creatine) were calculated for different tumors. Analysis was done to see statistically significant differences in metabolite ratios of different grades of gliomas and to differentiate high-grade gliomas from metastases.\u0000 Result A total of 61 cases with brain tumor were included in the study. Of which, 20 cases were of gliomas, 11 metastases, 9 meningiomas, 4 dysembryoplastic neuroepithelial tumors, 6 pituitary macroadenomas, 4 trigeminal schwannomas, 3 craniopharyngiomas, 2 acoustic schwannomas, and 2 medulloblastomas. Statistically significant differences in ratios of metabolite peaks were noted between different grades of gliomas and for high-grade glioma versus metastases.\u0000 Conclusion MRS compliments the MR imaging and stands out as problem-solving method to distinguish neoplastic lesions in selected cases and also has a role in grading of gliomas and in differentiation of types of malignancies.","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42902632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Chhabra, S. Sancheti, A. Sali, P. Somal, Aishwarya Sharma, R. Brar, A. Gulia, Rakesh Kapoor
{"title":"Erratum: Approach to the Diagnosis of Hepatoid Adenocarcinoma, an Under-reported Entity: Case Series and Review of Literature","authors":"P. Chhabra, S. Sancheti, A. Sali, P. Somal, Aishwarya Sharma, R. Brar, A. Gulia, Rakesh Kapoor","doi":"10.1055/s-0042-1756342","DOIUrl":"https://doi.org/10.1055/s-0042-1756342","url":null,"abstract":"","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48602552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Primary ovarian lymphomas constitute 0.5% of all ovarian malignancies. We report one such case in a middle-aged woman who presented with a bilateral ovarian tumor. Bilateral oophorectomy with salpingectomy was sent for frozen section analysis that revealed a round cell tumor. Final histopathology showed a mitotically active small round blue cell tumor arranged in diffuse sheets and chords with an evident starry-sky pattern. Extensive immunohistochemistry (IHC) panel was performed. Histopathology along with IHC did not classify the tumor into diffuse-large-B cell-lymphoma or Burkitt lymphoma and a final diagnosis of high-grade B cell lymphoma (HGBL) was made. This case is presented for its rarity and to discuss the challenges on IHC to subclassify a lymphoma as HGBL. Although rare, the possibility of primary ovarian non-Hodgkin lymphoma should be kept in mind when dealing with bilateral ovarian tumors as a timely and accurate diagnosis can save unnecessary surgeries and improve outcome.
{"title":"Primary Bilateral Ovarian Lymphoma: A Rare Case Report","authors":"Salwa Bano, V. Ramaswamy, C. Chandrashekar","doi":"10.1055/s-0042-1753497","DOIUrl":"https://doi.org/10.1055/s-0042-1753497","url":null,"abstract":"Primary ovarian lymphomas constitute 0.5% of all ovarian malignancies. We report one such case in a middle-aged woman who presented with a bilateral ovarian tumor. Bilateral oophorectomy with salpingectomy was sent for frozen section analysis that revealed a round cell tumor. Final histopathology showed a mitotically active small round blue cell tumor arranged in diffuse sheets and chords with an evident starry-sky pattern. Extensive immunohistochemistry (IHC) panel was performed. Histopathology along with IHC did not classify the tumor into diffuse-large-B cell-lymphoma or Burkitt lymphoma and a final diagnosis of high-grade B cell lymphoma (HGBL) was made. This case is presented for its rarity and to discuss the challenges on IHC to subclassify a lymphoma as HGBL. Although rare, the possibility of primary ovarian non-Hodgkin lymphoma should be kept in mind when dealing with bilateral ovarian tumors as a timely and accurate diagnosis can save unnecessary surgeries and improve outcome.","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48765333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. M. Masamayor, J. J. Besa, C. S. Tan-Lim, A. Pajes, Lia M. Palileo-Villanueva
Although prevention is vital in managing tumor lysis syndrome (TLS), no study directly compares various regimens. This study compared the effectiveness and safety of urate-lowering agents in preventing TLS. Databases were searched for randomized controlled trials involving adults with hematologic or solid malignancies on chemotherapy or cytoreductive agents given allopurinol, febuxostat, or rasburicase alone or in combination at any dose, form, or frequency published in English by December 2021. Outcomes included laboratory and clinical TLS expressed as relative risks, adverse events as described by authors, and mean serum uric acid (sUA) as mean differences of area under the curve. A network of meta-analysis and post-hoc meta-analysis based on TLS risk using a random-effects model was done using Stata 14.0 and Review Manager 5.3, respectively. Certainty of evidence was assessed using the GRADE approach. Three studies with a total of 633 participants given allopurinol, febuxostat, rasburicase, or rasburicase combined with allopurinol were included. Rasburicase is more effective than allopurinol in preventing laboratory TLS (relative risk: 0.51; 95% confidence interval [CI]: 0.32–0.81) based on moderate quality evidence. No significant differences were observed in clinical TLS. Adverse events were attributable to toxicities of chemotherapy. Rasburicase alone or in combination with allopurinol was better than allopurinol or febuxostat alone in reducing sUA level. Febuxostat is more effective than allopurinol in lowering sUA levels among patients at high-risk of TLS (mean difference −125.75; 95% CI: −223.47 to −28.02). Rasburicase may be the most effective agent in preventing laboratory TLS and maintaining low sUA levels.
{"title":"Effectiveness and Safety of Allopurinol, Febuxostat, and Rasburicase in the Prevention of Tumor Lysis Syndrome: A Systematic Review and Network Meta-analysis","authors":"E. M. Masamayor, J. J. Besa, C. S. Tan-Lim, A. Pajes, Lia M. Palileo-Villanueva","doi":"10.1055/s-0042-1750701","DOIUrl":"https://doi.org/10.1055/s-0042-1750701","url":null,"abstract":"Although prevention is vital in managing tumor lysis syndrome (TLS), no study directly compares various regimens. This study compared the effectiveness and safety of urate-lowering agents in preventing TLS. Databases were searched for randomized controlled trials involving adults with hematologic or solid malignancies on chemotherapy or cytoreductive agents given allopurinol, febuxostat, or rasburicase alone or in combination at any dose, form, or frequency published in English by December 2021. Outcomes included laboratory and clinical TLS expressed as relative risks, adverse events as described by authors, and mean serum uric acid (sUA) as mean differences of area under the curve. A network of meta-analysis and post-hoc meta-analysis based on TLS risk using a random-effects model was done using Stata 14.0 and Review Manager 5.3, respectively. Certainty of evidence was assessed using the GRADE approach. Three studies with a total of 633 participants given allopurinol, febuxostat, rasburicase, or rasburicase combined with allopurinol were included. Rasburicase is more effective than allopurinol in preventing laboratory TLS (relative risk: 0.51; 95% confidence interval [CI]: 0.32–0.81) based on moderate quality evidence. No significant differences were observed in clinical TLS. Adverse events were attributable to toxicities of chemotherapy. Rasburicase alone or in combination with allopurinol was better than allopurinol or febuxostat alone in reducing sUA level. Febuxostat is more effective than allopurinol in lowering sUA levels among patients at high-risk of TLS (mean difference −125.75; 95% CI: −223.47 to −28.02). Rasburicase may be the most effective agent in preventing laboratory TLS and maintaining low sUA levels.","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46260232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Shanmugam, S. Susikar, T. Bharanidharan, V. Veerappan
Background Tongue cancers are more common in the Indian subcontinent and a leading cause of morbidity and mortality among oral cavity cancers. Induction chemotherapy has been considered an intriguing and smart option for many reasons, but even after years of studies and debates, its role has not been fully established in the management of tongue cancers. Materials and Methods In this study, we evaluated 17 patients with oral tongue carcinomas with locally advanced stage, enrolled into a protocol of three drug (docetaxel, cisplatin, 5-fluorouracil) induction chemotherapy for three cycles. After completion of the three cycles, patients were clinically and radiologically re-evaluated and surgery was done if locally operable. Results At the completion of three cycles, five patients were partial responders, four patients were complete responders, and five patients had progressive disease after three cycles. Those patients with response underwent surgery. There were no significant morbid intraoperative or postoperative complications observed in seven out of nine patients. At the end of treatment completion, five out of nine patients had tumor residue/high-risk features and were planned for adjuvant radiotherapy. Conclusion For locally advanced oral tongue carcinomas, the role of induction chemotherapy before surgery has been fruitful and its impact on function preservation with acceptable oncological clearance is an emerging alternative. Spacing chemotherapy and radiotherapy reduce the incidence of adverse effects of combined treatment.
{"title":"Induction Chemotherapy in Squamous Cell Carcinoma of Tongue—Still a Slippery Role?","authors":"S. Shanmugam, S. Susikar, T. Bharanidharan, V. Veerappan","doi":"10.1055/s-0042-1750351","DOIUrl":"https://doi.org/10.1055/s-0042-1750351","url":null,"abstract":"\u0000 Background Tongue cancers are more common in the Indian subcontinent and a leading cause of morbidity and mortality among oral cavity cancers. Induction chemotherapy has been considered an intriguing and smart option for many reasons, but even after years of studies and debates, its role has not been fully established in the management of tongue cancers.\u0000 Materials and Methods In this study, we evaluated 17 patients with oral tongue carcinomas with locally advanced stage, enrolled into a protocol of three drug (docetaxel, cisplatin, 5-fluorouracil) induction chemotherapy for three cycles. After completion of the three cycles, patients were clinically and radiologically re-evaluated and surgery was done if locally operable.\u0000 Results At the completion of three cycles, five patients were partial responders, four patients were complete responders, and five patients had progressive disease after three cycles. Those patients with response underwent surgery. There were no significant morbid intraoperative or postoperative complications observed in seven out of nine patients. At the end of treatment completion, five out of nine patients had tumor residue/high-risk features and were planned for adjuvant radiotherapy.\u0000 Conclusion For locally advanced oral tongue carcinomas, the role of induction chemotherapy before surgery has been fruitful and its impact on function preservation with acceptable oncological clearance is an emerging alternative. Spacing chemotherapy and radiotherapy reduce the incidence of adverse effects of combined treatment.","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49266794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Purushothaman, Sugeeth M. Thambi, M. M. Abraham, Sindhu Nair P
Ewing's sarcoma is a neoplasm of the undifferentiated small round cells, which generally affects the bone and deep soft tissues of children and adolescents. Extraskeletal Ewing's sarcomas are less common than skeletal Ewing's sarcoma with the most common sites being chest wall, retroperitoneal space, lower extremities, paravertebral region, and gluteal region. Primary Ewing's sarcoma of the gastrointestinal tract is rare. The rarity of cases, lack of specific literature, or guidelines for treatment and varying presentations make these cases challenging to diagnose and to treat. In this series, we share our experience from a tertiary cancer care center in South India. By our knowledge, this is the first case series in literature sharing the experience from a single center in treating four cases of gastrointestinal Ewing's sarcoma.
{"title":"Ewing's Sarcoma of the Gastrointestinal Tract—A Case Series","authors":"P. Purushothaman, Sugeeth M. Thambi, M. M. Abraham, Sindhu Nair P","doi":"10.1055/s-0042-1751114","DOIUrl":"https://doi.org/10.1055/s-0042-1751114","url":null,"abstract":"Ewing's sarcoma is a neoplasm of the undifferentiated small round cells, which generally affects the bone and deep soft tissues of children and adolescents. Extraskeletal Ewing's sarcomas are less common than skeletal Ewing's sarcoma with the most common sites being chest wall, retroperitoneal space, lower extremities, paravertebral region, and gluteal region. Primary Ewing's sarcoma of the gastrointestinal tract is rare. The rarity of cases, lack of specific literature, or guidelines for treatment and varying presentations make these cases challenging to diagnose and to treat. In this series, we share our experience from a tertiary cancer care center in South India. By our knowledge, this is the first case series in literature sharing the experience from a single center in treating four cases of gastrointestinal Ewing's sarcoma.","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49410858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Increasing number of young breast cancer patients are seen in India and many of these young breast cancer patients are considered to have more aggressive disease biology. Aim The aim of this article was to study the clinicopathological profile of breast cancer patients in the young and older patients to understand the difference between these two groups. Methods This was a retrospective study conducted on 421 breast cancer patients. Results Total of 421 breast cancer patients were studied, out of which 158 patients were less than or equal to 40 years age group and 263 patients were in more than or equal to 50 years age group. Commonest T stage on presentation was T2, which was seen 56.32% of young breast cancer patients and in 64.64% of older patients. Higher nodal spread was seen in younger patients when compared with older patients (p-value = 0.00001). Older group patients had significant decline from anatomical to pathological prognostic stage group compared with younger group (29 vs. 13.29%; p-value = 0.00001). Grade 3 tumors were seen in 58.23% of younger patients and 22.05% of older patients (p-value = 0.00001). Triple-negative breast cancer was seen more commonly in younger group compared with older group (p-value = 0.0088). Conclusions Significant number of breast cancer patients present in younger age group in India. Younger breast cancer patients tend to have higher grade tumors and triple-negative breast cancer is common in younger age groups. Pathological prognostic stage grouping appears clinically more relevant than anatomical stage groups.
{"title":"The Clinicopathological Profile of Breast Cancer in Young Women from a Tertiary Care Center","authors":"Dinesh Shet, R. Gatty, A. Shetty, M. Baliga","doi":"10.1055/s-0042-1750352","DOIUrl":"https://doi.org/10.1055/s-0042-1750352","url":null,"abstract":"\u0000 Background Increasing number of young breast cancer patients are seen in India and many of these young breast cancer patients are considered to have more aggressive disease biology.\u0000 Aim The aim of this article was to study the clinicopathological profile of breast cancer patients in the young and older patients to understand the difference between these two groups.\u0000 Methods This was a retrospective study conducted on 421 breast cancer patients.\u0000 Results Total of 421 breast cancer patients were studied, out of which 158 patients were less than or equal to 40 years age group and 263 patients were in more than or equal to 50 years age group. Commonest T stage on presentation was T2, which was seen 56.32% of young breast cancer patients and in 64.64% of older patients. Higher nodal spread was seen in younger patients when compared with older patients (p-value = 0.00001). Older group patients had significant decline from anatomical to pathological prognostic stage group compared with younger group (29 vs. 13.29%; p-value = 0.00001). Grade 3 tumors were seen in 58.23% of younger patients and 22.05% of older patients (p-value = 0.00001). Triple-negative breast cancer was seen more commonly in younger group compared with older group (p-value = 0.0088).\u0000 Conclusions Significant number of breast cancer patients present in younger age group in India. Younger breast cancer patients tend to have higher grade tumors and triple-negative breast cancer is common in younger age groups. Pathological prognostic stage grouping appears clinically more relevant than anatomical stage groups.","PeriodicalId":31357,"journal":{"name":"Asian Journal of Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41797593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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