Pub Date : 2023-07-01DOI: 10.4103/jiaomr.jiaomr_105_23
D. Patil, Dhavneet Dheer
Background: Temporomandibular disorder (TMD) is a comprehensive term used to describe a diverse range of disorders with multiple causes. Psychological factors exhibit variability across different cases based on the diagnostic subgroup of temporomandibular disorders (TMD). Objectives: To compare the effectiveness of cognitive behavioral therapy (CBT) in TMD patients to the standard therapy (STD). Methods: Patients underwent psychological assessment by Beck's Inventory of Depression (BDI) and stress symptom rating scale (SSRS). They were randomly divided into STD therapy and CBT. Pre- and post-treatment pain was evaluated by VAS. BDI and SSRS scale scores were done pre- and post-CBT and STD treatment. Descriptive statistics and non-parametric tests were performed to compare the variables pre- and post-CBT and STD treatment. Results: Varying degrees of depression and stress 53.3% and 60%, respectively, were observed in patients with TMDs. A statistically significant difference was seen in the BDI and VAS scores post-CBT (P < 0.001) as compared to SSRS scores. Conclusion: Patients with TMDs are under considerable stress and anxiety. The addition of CBT to standard treatment regimens will enhance the treatment efficacy and help patients to cope with daily activities, ease muscle tension, and improve their quality of life.
背景：颞下颌关节紊乱症（TMD）是一个综合性术语，用于描述具有多种病因的各种疾病。根据颞下颌关节紊乱症（TMD）的诊断分组，心理因素在不同病例中表现出差异性。研究目的比较认知行为疗法（CBT）与标准疗法（STD）对 TMD 患者的疗效。方法：对患者进行心理评估：患者通过贝克抑郁量表（BDI）和压力症状评定量表（SSRS）进行心理评估。他们被随机分为 STD 治疗和 CBT 治疗。治疗前后的疼痛通过 VAS 进行评估。BDI和SSRS量表评分在CBT和STD治疗前后进行。通过描述性统计和非参数检验来比较治疗前后的变量。结果如下在 TMD 患者中观察到不同程度的抑郁和压力，分别为 53.3% 和 60%。与 SSRS 评分相比，CBT 治疗后的 BDI 和 VAS 评分差异有统计学意义（P < 0.001）。结论：TMD 患者承受着巨大的压力和焦虑。在标准治疗方案中加入 CBT 将提高治疗效果，帮助患者应对日常活动，缓解肌肉紧张，提高生活质量。
{"title":"Psychological assessment and cognitive behavioral therapy in temporomandibular joint disorders: A randomized controlled study","authors":"D. Patil, Dhavneet Dheer","doi":"10.4103/jiaomr.jiaomr_105_23","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_105_23","url":null,"abstract":"Background: Temporomandibular disorder (TMD) is a comprehensive term used to describe a diverse range of disorders with multiple causes. Psychological factors exhibit variability across different cases based on the diagnostic subgroup of temporomandibular disorders (TMD). Objectives: To compare the effectiveness of cognitive behavioral therapy (CBT) in TMD patients to the standard therapy (STD). Methods: Patients underwent psychological assessment by Beck's Inventory of Depression (BDI) and stress symptom rating scale (SSRS). They were randomly divided into STD therapy and CBT. Pre- and post-treatment pain was evaluated by VAS. BDI and SSRS scale scores were done pre- and post-CBT and STD treatment. Descriptive statistics and non-parametric tests were performed to compare the variables pre- and post-CBT and STD treatment. Results: Varying degrees of depression and stress 53.3% and 60%, respectively, were observed in patients with TMDs. A statistically significant difference was seen in the BDI and VAS scores post-CBT (P < 0.001) as compared to SSRS scores. Conclusion: Patients with TMDs are under considerable stress and anxiety. The addition of CBT to standard treatment regimens will enhance the treatment efficacy and help patients to cope with daily activities, ease muscle tension, and improve their quality of life.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"28 1","pages":"326 - 330"},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/jiaomr.jiaomr_129_23
Syed Zakaullah, S. Ara, Sameena Parveen, Sayeda Bangi
Background: Mobile multimedia platforms (MMPs) are prolific tools that can be used by individuals and corporations to share content. However, few studies have shown the effectiveness of MMPs as educational tools. Objective: To evaluate the effectiveness of MMPs in improving basic dental diagnostic skills. Materials and Methods: In this voluntary interventional study on 70 dental students, we created pilot learning modules through an MMP called Instagram Stories to teach dental diagnosis. We evaluated the efficacy of the modules through diagnostic tests that were given to dental students. Results: The students showed a significant increase in diagnostic test scores after the use of an MMP. Furthermore, the students' feedback on the MMP indicated that most students found it easy and enjoyable to use. Conclusion: Our study data show that MMPs may be used to improve training in basic dental diagnostic skills and can serve as an adjunct teaching tool. Moreover, MMP modules can potentially enrich professional education in developing countries where access to educational resources is limited.
{"title":"Using mobile multimedia platform for teaching radiographic diagnosis","authors":"Syed Zakaullah, S. Ara, Sameena Parveen, Sayeda Bangi","doi":"10.4103/jiaomr.jiaomr_129_23","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_129_23","url":null,"abstract":"Background: Mobile multimedia platforms (MMPs) are prolific tools that can be used by individuals and corporations to share content. However, few studies have shown the effectiveness of MMPs as educational tools. Objective: To evaluate the effectiveness of MMPs in improving basic dental diagnostic skills. Materials and Methods: In this voluntary interventional study on 70 dental students, we created pilot learning modules through an MMP called Instagram Stories to teach dental diagnosis. We evaluated the efficacy of the modules through diagnostic tests that were given to dental students. Results: The students showed a significant increase in diagnostic test scores after the use of an MMP. Furthermore, the students' feedback on the MMP indicated that most students found it easy and enjoyable to use. Conclusion: Our study data show that MMPs may be used to improve training in basic dental diagnostic skills and can serve as an adjunct teaching tool. Moreover, MMP modules can potentially enrich professional education in developing countries where access to educational resources is limited.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"116 1","pages":"335 - 340"},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/jiaomr.jiaomr_79_23
Sarah Afaque, Ribhu Ganguly, N. Misra, D. Umapathy
Recurrent aphthous stomatitis (RAS) or ulcer (RAU) is a common disorder affecting 5% to 60% of examined adult patient groups, with a female predominance. In this article, we report a case series of five patients with recurring oral ulcers, experiencing intense episodes. They were subsequently treated with laser therapy. It was recorded that laser therapy caused an immediate improvement in pain and discomfort, with spontaneous healing of aphthous ulcers without any apparent side effects.
{"title":"Instantaneous efficacy of laser therapy in recurrent aphthous stomatitis: A clinical case series","authors":"Sarah Afaque, Ribhu Ganguly, N. Misra, D. Umapathy","doi":"10.4103/jiaomr.jiaomr_79_23","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_79_23","url":null,"abstract":"Recurrent aphthous stomatitis (RAS) or ulcer (RAU) is a common disorder affecting 5% to 60% of examined adult patient groups, with a female predominance. In this article, we report a case series of five patients with recurring oral ulcers, experiencing intense episodes. They were subsequently treated with laser therapy. It was recorded that laser therapy caused an immediate improvement in pain and discomfort, with spontaneous healing of aphthous ulcers without any apparent side effects.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"143 1","pages":"443 - 445"},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/jiaomr.jiaomr_90_23
T. Saravanan, RR Mahendra Raj, P. Preethi, Ilamurugan Ezhilarasi, Shakila Ramalingam
Background: Hard tooth structures are susceptible to direct radiation damage. Dental sensitivity is more often encountered and the most distressing effect in post-radiotherapy patients. Fluoride varnishes are commonly used in dentistry to alleviate dentinal sensitivity. Employing fluoride varnishes in patients with dentinal sensitivity under palliative care can be evaluated. Objectives: To compare and evaluate the desensitizing effect of three fluoride varnishes in patients with dentinal sensitivity under palliative care. To assess and compare the sustainable desensitizing effect of three fluoride varnishes after 3 months. Materials and Methods: The study includes 45 samples satisfying inclusion and exclusion criteria. The samples were divided into three equal groups (n = 15): group A, group B, and group C. Three fluoride varnishes used were 5% sodium fluoride with xylitol-coated calcium and phosphate (CXP), copal gum, isopropyl alcohol, 5% sodium fluoride, and 5% sodium fluoride with bioglass to groups A, B, and C, respectively. Data were collected before application and 24 hours after application, 7 days, and 3 months after application for all three groups in terms of VAS. Results: A statistically significant improvement in VAS score was observed between pretreatment and 24 hours posttreatment follow-ups in all three groups. Patients under group C showed more improvements than the other two groups. In subsequent follow-ups on the 7th day and 3 months, patients under group C were observed to have sustained effects compared with the other two groups. Conclusion: Among the three compared fluoride varnishes, 5% sodium fluoride with bioglass proved to have a better immediate and sustained desensitizing effect in patients with dentinal sensitivity under palliative care.
背景：硬质牙齿结构容易受到直接辐射损伤。牙齿敏感是放疗后患者最常见和最痛苦的症状。牙科常用氟化物清漆来缓解牙科敏感。在姑息治疗中，可以对牙科敏感患者使用氟化物清漆的情况进行评估。目标：比较和评估三种氟化物清漆对接受姑息治疗的牙本质敏感患者的脱敏效果。评估和比较三种氟化物清漆在 3 个月后的持续脱敏效果。材料和方法：研究包括 45 个符合纳入和排除标准的样本。A 组、B 组和 C 组分别使用 5%氟化钠加木糖醇包衣磷酸钙（CXP）、椰油树胶、异丙醇、5% 氟化钠和 5%氟化钠加生物玻璃。在使用前、使用后 24 小时、使用后 7 天和使用后 3 个月，收集所有三组的 VAS 数据。结果显示三组患者在治疗前和治疗后 24 小时随访期间的 VAS 评分均有明显改善，差异有统计学意义。C 组患者的改善程度高于其他两组。在随后第 7 天和 3 个月的随访中，观察到 C 组患者的疗效比其他两组更持久。结论在三种比较的氟化物清漆中，5% 含生物玻璃的氟化钠对接受姑息治疗的牙本质敏感患者具有更好的即时和持续脱敏效果。
{"title":"Comparative evaluation of desensitizing effect of three fluoride varnishes in patients with dentinal sensitivity under palliative care: A cross-sectional study","authors":"T. Saravanan, RR Mahendra Raj, P. Preethi, Ilamurugan Ezhilarasi, Shakila Ramalingam","doi":"10.4103/jiaomr.jiaomr_90_23","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_90_23","url":null,"abstract":"Background: Hard tooth structures are susceptible to direct radiation damage. Dental sensitivity is more often encountered and the most distressing effect in post-radiotherapy patients. Fluoride varnishes are commonly used in dentistry to alleviate dentinal sensitivity. Employing fluoride varnishes in patients with dentinal sensitivity under palliative care can be evaluated. Objectives: To compare and evaluate the desensitizing effect of three fluoride varnishes in patients with dentinal sensitivity under palliative care. To assess and compare the sustainable desensitizing effect of three fluoride varnishes after 3 months. Materials and Methods: The study includes 45 samples satisfying inclusion and exclusion criteria. The samples were divided into three equal groups (n = 15): group A, group B, and group C. Three fluoride varnishes used were 5% sodium fluoride with xylitol-coated calcium and phosphate (CXP), copal gum, isopropyl alcohol, 5% sodium fluoride, and 5% sodium fluoride with bioglass to groups A, B, and C, respectively. Data were collected before application and 24 hours after application, 7 days, and 3 months after application for all three groups in terms of VAS. Results: A statistically significant improvement in VAS score was observed between pretreatment and 24 hours posttreatment follow-ups in all three groups. Patients under group C showed more improvements than the other two groups. In subsequent follow-ups on the 7th day and 3 months, patients under group C were observed to have sustained effects compared with the other two groups. Conclusion: Among the three compared fluoride varnishes, 5% sodium fluoride with bioglass proved to have a better immediate and sustained desensitizing effect in patients with dentinal sensitivity under palliative care.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"15 1","pages":"355 - 358"},"PeriodicalIF":0.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jiaomr.jiaomr_145_22
S. Jayachandran, M. Archana
Background: Cone-beam computed tomography (CBCT) systems are frequently used to image bones for research purposes to investigate trabecular and cortical changes in bone disorders. A unique technique that may be used for the early diagnosis of bone lesions is fractal dimension (FD) analysis and bone architecture analysis using CBCT scans. Aim: To assess and compare the changes in trabecular bone architecture in fibro-osseous lesions by bone image analysis and FD analysis in CBCT scans of fibro-osseous lesions. Materials and Methods: This retrospective analysis included the CBCT scans of 25 patients from archival records of the Department of Oral Medicine and Radiology. As per specific exclusion and inclusion criteria, the radiographs were chosen. To establish a noninvasive assessment of the bone structure, CBCT scans were subjected to bone architecture analysis and FD analysis using box-counting (with ImageJ software). Results and Conclusions: The FD values and bone parameter values on the affected and the normal side will be recorded and analyzed using SPSS version 22. There was a statistically significant difference in the FD values between the normal and abnormal sides in all fibro-osseous lesions. Five parameters in fibrous dysplasia showed a significant statistical difference in comparison to the normal and abnormal sides. It can be concluded that FD analysis provides a novel technique for the early detection of fibro-osseous lesions.
{"title":"CBCT-based evaluation of bone microarchitecture in fibro osseous lesions using image analysis - A retrospective radiographic study","authors":"S. Jayachandran, M. Archana","doi":"10.4103/jiaomr.jiaomr_145_22","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_145_22","url":null,"abstract":"Background: Cone-beam computed tomography (CBCT) systems are frequently used to image bones for research purposes to investigate trabecular and cortical changes in bone disorders. A unique technique that may be used for the early diagnosis of bone lesions is fractal dimension (FD) analysis and bone architecture analysis using CBCT scans. Aim: To assess and compare the changes in trabecular bone architecture in fibro-osseous lesions by bone image analysis and FD analysis in CBCT scans of fibro-osseous lesions. Materials and Methods: This retrospective analysis included the CBCT scans of 25 patients from archival records of the Department of Oral Medicine and Radiology. As per specific exclusion and inclusion criteria, the radiographs were chosen. To establish a noninvasive assessment of the bone structure, CBCT scans were subjected to bone architecture analysis and FD analysis using box-counting (with ImageJ software). Results and Conclusions: The FD values and bone parameter values on the affected and the normal side will be recorded and analyzed using SPSS version 22. There was a statistically significant difference in the FD values between the normal and abnormal sides in all fibro-osseous lesions. Five parameters in fibrous dysplasia showed a significant statistical difference in comparison to the normal and abnormal sides. It can be concluded that FD analysis provides a novel technique for the early detection of fibro-osseous lesions.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"35 1","pages":"71 - 74"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42529190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jiaomr.jiaomr_322_22
A. Al-Amiry, Areej Najem
Background: Osteoporosis is a systemic skeletal disease that weakens bones by lowering mineral density and causing micro-architectural degradation of bony tissue. Aim: This study was conducted to examine the use of vitamin D, calcium, and estrogen levels in saliva as biomarkers for early detection of osteoporosis. Materials and Methods: Ninety postmenopausal women were divided into three groups based on T-scores from dual-energy X-ray absorptiometry scans. The groups consist of 30 women with osteoporosis, 30 women with osteopenia, and 30 women serving as controls. The enzyme-linked immunosorbent assay was used to look for vitamin D and estrogen in the saliva by specific vitamin D3 and estradiol kits. Calcium concentrations were measured by a colorimetric method. Results: The level of salivary biomarkers (vitamin D, calcium, and estrogen) showed a clear distinction between the groups analyzed. Salivary estrogen and vitamin D levels were significantly lower in patients with osteoporosis compared to those with osteopenia and controls. The highest concentration of calcium was found in the osteoporosis group's saliva compared to the other groups. Conclusion: The results highlight the significance of vitamin D, calcium, and estrogen in saliva as a simple, noninvasive biomarker in diagnosing postmenopausal osteoporosis.
{"title":"Salivary biomarkers (Vitamin D, Calcium, and Estrogen Hormone) in postmenopausal women with osteoporosis","authors":"A. Al-Amiry, Areej Najem","doi":"10.4103/jiaomr.jiaomr_322_22","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_322_22","url":null,"abstract":"Background: Osteoporosis is a systemic skeletal disease that weakens bones by lowering mineral density and causing micro-architectural degradation of bony tissue. Aim: This study was conducted to examine the use of vitamin D, calcium, and estrogen levels in saliva as biomarkers for early detection of osteoporosis. Materials and Methods: Ninety postmenopausal women were divided into three groups based on T-scores from dual-energy X-ray absorptiometry scans. The groups consist of 30 women with osteoporosis, 30 women with osteopenia, and 30 women serving as controls. The enzyme-linked immunosorbent assay was used to look for vitamin D and estrogen in the saliva by specific vitamin D3 and estradiol kits. Calcium concentrations were measured by a colorimetric method. Results: The level of salivary biomarkers (vitamin D, calcium, and estrogen) showed a clear distinction between the groups analyzed. Salivary estrogen and vitamin D levels were significantly lower in patients with osteoporosis compared to those with osteopenia and controls. The highest concentration of calcium was found in the osteoporosis group's saliva compared to the other groups. Conclusion: The results highlight the significance of vitamin D, calcium, and estrogen in saliva as a simple, noninvasive biomarker in diagnosing postmenopausal osteoporosis.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"35 1","pages":"41 - 44"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41919489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jiaomr.jiaomr_268_22
B. Rajarathnam, N. Rakesh, Anita Murali, J. Anbu, M. Asha
Background: Submucous fibrosis (SMF) was recognized as a definitive lesion by Schwartz who described it as a fibrosing condition in 1952 and due to its predilection for afflicting multiple sites in the oral cavity the disorder was listed as a “premalignant/precancerous condition”. Tissue transglutaminase 2 (TG2) catalyzes the cross-linkage between glutamine (Gln) and lysine (Lys) side chains. Cysteamine by virtue of being a transglutaminase 2 substrate, acts as a competitive inhibitor of the other amine substrates of this enzyme. In-vitro studies have reported the existence of a correlation between TG2 and SMF. Aim: The present study was carried out to evaluate Transglutaminase2 (TG2) and its therapeutic intervention by cysteamine hydrochloride in SMF-affected Wistar rats. Methods: The present experimental study was carried out on male Wistar rats, in which arecoline was injected into the right buccal mucosa for induction of SMF, and levels of TG2 were estimated using ELISA. The drug was administered to disease-induced Wistar rats from the 91st day for inhibition of TG2 and the post-treatment levels of TG2 were evaluated by ELISA at three regular intervals (97th, 104th, 111th days). Results: The Animal model exhibited a successful induction of SMF similar to the histopathological features of human SMF. The levels of TG2 were significantly elevated in the experimental animals compared with the healthy animal group up on the induction of the disease process. On administration of cysteamine to the SMF-affected animals, TG2 levels significant reduction by the 111st day was observed. Conclusion: The results from this present study highlight the newer therapeutic option for SMF. Exploring the old drug cysteamine can be a significant forward step towards novel treatment strategies for the treatment of SMF.
{"title":"Cysteamine hydrochloride, a transglutaminase2 inhibitor as therapeutic potential for oral submucous fibrosis","authors":"B. Rajarathnam, N. Rakesh, Anita Murali, J. Anbu, M. Asha","doi":"10.4103/jiaomr.jiaomr_268_22","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_268_22","url":null,"abstract":"Background: Submucous fibrosis (SMF) was recognized as a definitive lesion by Schwartz who described it as a fibrosing condition in 1952 and due to its predilection for afflicting multiple sites in the oral cavity the disorder was listed as a “premalignant/precancerous condition”. Tissue transglutaminase 2 (TG2) catalyzes the cross-linkage between glutamine (Gln) and lysine (Lys) side chains. Cysteamine by virtue of being a transglutaminase 2 substrate, acts as a competitive inhibitor of the other amine substrates of this enzyme. In-vitro studies have reported the existence of a correlation between TG2 and SMF. Aim: The present study was carried out to evaluate Transglutaminase2 (TG2) and its therapeutic intervention by cysteamine hydrochloride in SMF-affected Wistar rats. Methods: The present experimental study was carried out on male Wistar rats, in which arecoline was injected into the right buccal mucosa for induction of SMF, and levels of TG2 were estimated using ELISA. The drug was administered to disease-induced Wistar rats from the 91st day for inhibition of TG2 and the post-treatment levels of TG2 were evaluated by ELISA at three regular intervals (97th, 104th, 111th days). Results: The Animal model exhibited a successful induction of SMF similar to the histopathological features of human SMF. The levels of TG2 were significantly elevated in the experimental animals compared with the healthy animal group up on the induction of the disease process. On administration of cysteamine to the SMF-affected animals, TG2 levels significant reduction by the 111st day was observed. Conclusion: The results from this present study highlight the newer therapeutic option for SMF. Exploring the old drug cysteamine can be a significant forward step towards novel treatment strategies for the treatment of SMF.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"35 1","pages":"4 - 9"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47049505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jiaomr.jiaomr_91_23
M. Avinash Tejasvi
{"title":"Artificial intelligence—A new vista in health care","authors":"M. Avinash Tejasvi","doi":"10.4103/jiaomr.jiaomr_91_23","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_91_23","url":null,"abstract":"","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"35 1","pages":"1 - 1"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47452131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Determination of gender using skeletal remains presents a great problem to forensic experts. Among many anatomical landmarks in human skull, the mental foramen (MF) is a stable landmark. Objectives: To estimate gender of individuals by radiographic analysis of MF on computed tomography. Methods: A retrospective study was performed on 100 computed tomography images of patients. The sample was chosen in 1:1 ratio with 50 males and 50 females. Digital scale was used in computed tomography images for marking the tangents on superior and inferior border of MF and perpendiculars were drawn from tangents to lower border of mandible bilaterally and measurements were recorded. Results: The mean distance from the superior border of the MF to the lower border of the mandible and the inferior border of the MF to the lower border of the mandible on right and left sides was more in males when compared to females, which was statistically significant. Conclusion: The distances from the MF to the lower border of the mandible exhibit sexual dimorphism. This method is efficient and can be considered as an additional radiographic method to determine gender from skeletal remains.
{"title":"Determination of gender by radiographic analysis of mental foramen in computed tomography","authors":"MounikaReddy Mekala, Archana Pokala, Mashetty Ravali, BharathG C Gowda, VachepallyPraveen Reddy, VummadiKeerthi Reddy","doi":"10.4103/jiaomr.jiaomr_121_22","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_121_22","url":null,"abstract":"Background: Determination of gender using skeletal remains presents a great problem to forensic experts. Among many anatomical landmarks in human skull, the mental foramen (MF) is a stable landmark. Objectives: To estimate gender of individuals by radiographic analysis of MF on computed tomography. Methods: A retrospective study was performed on 100 computed tomography images of patients. The sample was chosen in 1:1 ratio with 50 males and 50 females. Digital scale was used in computed tomography images for marking the tangents on superior and inferior border of MF and perpendiculars were drawn from tangents to lower border of mandible bilaterally and measurements were recorded. Results: The mean distance from the superior border of the MF to the lower border of the mandible and the inferior border of the MF to the lower border of the mandible on right and left sides was more in males when compared to females, which was statistically significant. Conclusion: The distances from the MF to the lower border of the mandible exhibit sexual dimorphism. This method is efficient and can be considered as an additional radiographic method to determine gender from skeletal remains.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135400753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jiaomr.jiaomr_46_22
Amita Aditya, S. Patil, Antara Kore, V. Sawant
Intra-osseous vascular lesions occur rarely in jaw bones. Intra-osseous hemangioma of the facial bones is even rarer and occurs more predominantly in the mandible than the maxilla. Diagnosis of these lesions is challenging due to inconsistent clinical and radiographic presentation. Here, we present a rare case report of a boy, aged 16 years, with an intra-osseous cavernous hemangioma of the left maxilla.
{"title":"Cavernous hemangioma of maxilla: Report of a rare case","authors":"Amita Aditya, S. Patil, Antara Kore, V. Sawant","doi":"10.4103/jiaomr.jiaomr_46_22","DOIUrl":"https://doi.org/10.4103/jiaomr.jiaomr_46_22","url":null,"abstract":"Intra-osseous vascular lesions occur rarely in jaw bones. Intra-osseous hemangioma of the facial bones is even rarer and occurs more predominantly in the mandible than the maxilla. Diagnosis of these lesions is challenging due to inconsistent clinical and radiographic presentation. Here, we present a rare case report of a boy, aged 16 years, with an intra-osseous cavernous hemangioma of the left maxilla.","PeriodicalId":31366,"journal":{"name":"Journal of Indian Academy of Oral Medicine and Radiology","volume":"35 1","pages":"144 - 146"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49179624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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