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Seasonal Influenza and Pneumococcal Vaccination Rates Among Patients with Cancer in COVID-19 Pandemic: A Cross-Sectional Study COVID-19大流行期间癌症患者的季节性流感和肺炎球菌疫苗接种率:一项横断面研究
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/jos.2021-83087
E. Yekedüz, E. B. Köksoy, S. C. Yazgan, I. Akbıyık, S. Balli, E. Kavak, E. Kalacı, B. Dursun, Pınar Kubilay Tolunay, M. Gürbüz, H. Akbulut, A. Demirkazık, F. Çay Şenler, G. Utkan, Y. Ürün
Objective: Influenza and pneumococcal vaccination rates were not in the expected levels before the coronavirus disease-2019 (COVID-19) pandemic among patients with cancer. However, pandemic conditions may have changed the attitude of patients. In this study, we aimed to assess current influenza and pneumococcal vaccination rates of patients with cancer and changing attitudes toward vaccination in these patients. Material and Methods: This cross-sectional study was conducted in a tertiary cancer center in Turkey. A self-administered questionnaire consisting of 20 items was used. Results: A total of 309 patients completed the questionnaires. Most patients did not get a flu shot and pneumococcal vaccine before the COVID-19 pandemic (74.1% for flu shot and 84.1% for pneumococcal vaccine). Moreover, 144 patients (46.6%) stated that they were considering to get a flu shot, and 133 (43%) were considering to get a pneumococcal vaccine because of the COVID-19 pandemic. Only 35 patients (11.3%) got a flu shot, and 56 (18.1%) got a pneumococcal vaccine during the COVID-19 pan-demic. Conclusion: Vaccination rates for seasonal influenza and pneumococcal infections were low in patients with cancer before the COVID-19 pandemic. Although the number of patients who want to be vaccinated against seasonal influenza and pneumococcal infections increased in the COVID-19 pandemic, the number of patients vaccinated with these vaccines is still low. © 2021 by Turkish Society of Medical Oncology.
目的:在2019冠状病毒病(COVID-19)大流行之前,癌症患者的流感和肺炎球菌疫苗接种率未达到预期水平。然而,大流行的情况可能改变了患者的态度。在这项研究中,我们旨在评估当前癌症患者的流感和肺炎球菌疫苗接种率以及这些患者对疫苗接种态度的变化。材料和方法:本横断面研究在土耳其三级癌症中心进行。采用自填问卷,共20项。结果:共309例患者完成问卷调查。大多数患者在COVID-19大流行前未接种流感疫苗和肺炎球菌疫苗(74.1%接种流感疫苗,84.1%接种肺炎球菌疫苗)。此外,144名(46.6%)患者表示正在考虑接种流感疫苗,133名(43%)患者表示正在考虑接种肺炎球菌疫苗。在新冠肺炎大流行期间,接种流感疫苗的患者只有35人(11.3%),接种肺炎疫苗的患者只有56人(18.1%)。结论:2019冠状病毒病大流行前癌症患者季节性流感和肺炎球菌感染接种率较低。尽管在2019冠状病毒病大流行期间,希望接种季节性流感和肺炎球菌感染疫苗的患者人数有所增加,但接种这些疫苗的患者人数仍然很低。©土耳其肿瘤医学学会。
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引用次数: 0
The Impact of the COVID-19 Pandemic on Follow-Up and Management of Cancer Patients COVID-19大流行对癌症患者随访和管理的影响
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/jos.2021-83957
M. Karakurt Eryılmaz, M. Karaağaç, M. Koçak, M. Korkmaz, Muzaffer Uğraklı, Engin Hendem, A. Demirkıran, M. Er, D. Çağlayan, M. Araz, H. Bozcuk, M. Artaç
ABS TRACT Objective: This study aimed to evaluate the impact of the coronavirus disease-2019 (COVID-19) pandemic on the follow-up and management of cancer patients. Material and Methods: A survey consisting of 15 questions asking whether there was a delay in follow-up or treatment of cancer during the COVID-19 pandemic was applied to the cancer patients who were admitted to our medical oncology out-patient clinic for follow-up or treatment. Results: A total of 209 cancer patients were included in this study. In 56 (26.8%) patients, there was a delay in the follow-up or treatment of cancer. The delay in cancer treatment occurred in 37 (66%) patients, and the delay in the follow-up of cancer occurred in 19 (34%) patients. The median delay in the follow-up and treatment of cancer was both 30 days (range 1-120) and (range 2-120), respectively. 12.5% of all patients who encountered delays in cancer follow-up or treatment had subsequent cancer-related complications. Also, the delay was significantly higher in quarantined patients and patients diagnosed with severe acute respiratory syndrome-coronavirus-2. In binary logistic regression analysis, living in rural areas and being quarantined due to the COVID-19 pandemic were deter-mined as independent predictors of the delay. Conclusion: The COVID-19 outbreak caused delays in the follow-up and treatment of cancer patients, and acute complications arose due to unavoidable disruptions. To prevent long-term negative consequences of delays in cancer fol-low-up and treatment, it is necessary to adapt the treatments judiciously without sacrificing patient safety and care.
目的:探讨2019冠状病毒病(COVID-19)大流行对肿瘤患者随访和管理的影响。材料与方法:对我院肿瘤内科门诊住院随访或治疗的癌症患者进行调查,调查内容为:COVID-19大流行期间是否存在癌症随访或治疗延误问题。结果:本研究共纳入209例肿瘤患者。在56例(26.8%)患者中,有癌症随访或治疗的延迟。37例(66%)患者出现癌症治疗延迟,19例(34%)患者出现癌症随访延迟。癌症随访和治疗的中位延迟分别为30天(范围1-120)和(范围2-120)。在癌症随访或治疗中遇到延迟的所有患者中,有12.5%随后出现了癌症相关并发症。此外,在隔离患者和诊断为严重急性呼吸综合征-冠状病毒-2的患者中,延迟时间明显更高。在二元logistic回归分析中,确定农村生活和因COVID-19大流行而被隔离为延迟的独立预测因素。结论:新冠肺炎疫情导致癌症患者随访和治疗延迟,不可避免的干扰导致急性并发症。为了防止癌症随访和治疗延误的长期负面后果,有必要在不牺牲患者安全和护理的情况下明智地调整治疗方法。
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引用次数: 0
Distribution Data of Epidermal Growth Factor Receptor Mutations Detected by Next-Generation Sequencing Method in Non-Small Cell Lung Cancer 新一代测序法检测非小细胞肺癌中表皮生长因子受体突变的分布数据
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/jos.2021-84407
İ. Gökmen, E. Taştekin, A. Gökyer, Sezin Sayın, I. Çiçin
diagnosis and treatment, the incidence of lung cancer remains high both in Turkey and worldwide, and it is one of the leading causes of cancer-related deaths.1 When we evaluate Turkey, according to the age-standardized cancer rate in males, lung cancer occupies first place with 57.7%, and in females, it is at fifth place with 9.8%. 80% of lung cancer cases are nonsmall cell lung cancer (NSCLC), most of them are diagnosed at an advanced stage, and only 19% of patients can live for five years or longer.2 The dominant histological subtype in NSCLC is adenocarcinoma both in the world and in Turkey (47.1%).3
在诊断和治疗方面,肺癌的发病率在土耳其和世界范围内仍然很高,是癌症相关死亡的主要原因之一当我们对土耳其进行评估时,根据男性年龄标准化癌症发病率,肺癌以57.7%居首位,女性以9.8%居第五位。80%的肺癌病例为非小细胞肺癌(NSCLC),大多数是在晚期诊断出来的,只有19%的患者可以存活5年或更长时间在世界和土耳其,非小细胞肺癌的主要组织学亚型是腺癌(47.1%)
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引用次数: 0
Anti-Yo Associated Paraneoplastic Cerebellar Degeneration in Ovarian Cancer: A Rare Case Report 卵巢癌中抗- yo相关的副肿瘤小脑变性:一个罕见的病例报告
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/JOS.2020-78768
Yusuf Ilhan, M. Korkmaz, E. Güzel, K. Mammadova, S. S. Göksu, A. Tatlı, H. Coşkun
rare neurological complication in cancer, characterized by the rapid development of cerebellar ataxia resulting from tumor-induced autoimmunity against cerebellar Purkinje cells. It is mostly seen in gynecological cancers, breast cancer, and small cell lung cancer.1 AntiYo antibody, also known as anti-Purkinje cell cytoplasmic antibody type-1 is highly specific and the most frequently found antibody in patients with PCD. Other antibodies associated with PCD are anti-Hu, antiTr, anti-Ri, and anti-mGluR1. However, no antibodies are identified in nearly 40% of PCD patients.2-4 PCD occurs in about 0.2% of patients with malignant tumors and is characterized by cerebellar symptoms such as ataxia, vertigo, and dysarthria.5 Here, we present a case of anti-Yo-associated PCD in an ovarian cancer patient.
癌症中一种罕见的神经系统并发症,其特征是肿瘤诱导的针对小脑浦肯野细胞的自身免疫导致小脑共济失调的迅速发展。多见于妇科肿瘤、乳腺癌和小细胞肺癌AntiYo抗体,也称为抗浦肯野细胞质抗体1型,是PCD患者中最常见的特异性抗体。与PCD相关的其他抗体有抗hu、抗tr、抗ri和抗mglur1。然而,在近40%的PCD患者中没有发现抗体。2-4 PCD发生在约0.2%的恶性肿瘤患者中,以小脑症状为特征,如共济失调、眩晕和构音障碍在此,我们报告一例卵巢癌患者的抗yo相关性PCD。
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引用次数: 0
Association Between Blood Type and Epidermal Growth Factor Receptor Mutation Positivity in Lung Adenocarcinoma Patients 肺腺癌患者血型与表皮生长因子受体突变阳性的关系
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/JOS.2020-79248
M. Gürbüz, E. Akkuş, Bilgin Karaalioğlu, E. Aktaş, E. B. Köksoy, Hilal Özakıncı, S. Hayme, Y. Urun, S. Sak, A. Demirkazık, G. Utkan
EGFR is an important therapeutic target in lung adenocarcinoma.4 Oral tyrosine kinase inhibitors (TKIs) can be used in patients with driver mutations in EGFR.5 EGFR mutations were observed in ~1015% of NSCLC patients in Western populations and up to 50% in Asian populations.6,7 In a previous study, the EGFR mutation rate in adenocarcinomas was 33.9% for women and 9.4% for men in 499 cases, and the overall mutation rate was 14%.8 Also, EGFR mutations are more frequently detected in female patients and non-smokers.9
EGFR是肺腺癌的重要治疗靶点口服酪氨酸激酶抑制剂(TKIs)可用于EGFR驱动突变的患者,在西方人群中约1015%的NSCLC患者中观察到EGFR突变,在亚洲人群中高达50%。6,7在先前的一项研究中,在499例腺癌中,EGFR突变率女性为33.9%,男性为9.4%,总体突变率为14% 8此外,EGFR突变更常见于女性患者和非吸烟者
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引用次数: 0
Same Disease, Different Approaches: A Report on Six Lymphoma Cases with Extranodal Marginal Zones in Rare Sites 同病不同治:罕见部位结外边缘区淋巴瘤6例报告
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/JOS.2020-79452
Metin Demir, D. Guven, S. Kılıçkap
34 Marginal zone lymphomas (MZL) constitute around 10% of non-Hodgkins lymphomas. Extranodal marginal zone lymphoma (EMZL) is the most common form of MZL, constituting more than 70% of all MZL cases.1 Marginal zone lymphoma can be considered as a prototype of an antigen-driven tumor and has many microorganisms and autoimmune diseases associated with its pathogenesis.2 A pooled analysis of a series of trials showed that Sjögren’s Syndrome could increase the risk of MZL and EMZL of the parotid gland to 30 and 1000-folds, respectively. A similar association was also reported with systemic lupus erythematosus.3 The main causative infectious agents of the EMZL that were also associated with the specific disease locations were Helicobacter pylori, Chlamydia psittaci, Campylobacter jejuni, Borrelia burgdorferi, and Achromobacter xylosoxidans.4
边缘区淋巴瘤(MZL)约占非霍奇金淋巴瘤的10%。结外边缘区淋巴瘤(EMZL)是MZL最常见的形式,占所有MZL病例的70%以上边缘带淋巴瘤可被认为是抗原驱动肿瘤的原型,其发病机制与许多微生物和自身免疫性疾病相关一系列试验的汇总分析表明,Sjögren综合征可使腮腺MZL和EMZL的风险分别增加30倍和1000倍。系统性红斑狼疮也有类似的关联3 . EMZL的主要致病病原体为幽门螺杆菌、裸热衣原体、空肠弯曲杆菌、伯氏疏螺旋体和木氧无色杆菌
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引用次数: 1
Ixabepilone in Metastatic Breast Cancer: Real-World Experience 伊沙匹隆治疗转移性乳腺癌:真实世界的经验
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/jos.2021-81340
Ş. Gündüz, D. Erdem, D. Güven, S. Aksoy, M. Uysal, A. Kargi, A. Yıldız, I. Karaman, M. Özdoğan
85 Breast cancer is the most frequent diagnosis encountered in oncology clinics and the second cause of cancer-related mortality besides lung cancer among women worldwide.1 Although the methods of early detection have evolved, around 6% of women are still diagnosed with metastatic breast cancer at their first visit. In addition, as many as 30% of patients with non-metastatic early stage breast cancer will be diagnosed with distant metastatic disease during their disease course.2 Although there is currently no cure for metastatic breast cancer, newer systemic therapies have improved survival. Ixabepilone is an epothilone, a class of nontaxane microtubule-stabilizing agents that have activity in taxane-resistant patients. Many trials have demonstrated the efficacy of ixabepilone in chemotherapy-resistant tumors.3-5 This study assessed the efficacy of ixabepilone and compared two regimens of this drug in patients with metastatic breast cancer in daily clinical practice. Ixabepilone in Metastatic Breast Cancer: Real-World Experience
85乳腺癌是肿瘤诊所最常见的诊断,也是全世界妇女除肺癌外癌症相关死亡的第二大原因尽管早期检测的方法已经发展,但大约6%的妇女在第一次就诊时仍被诊断为转移性乳腺癌。此外,多达30%的非转移性早期乳腺癌患者在病程中会被诊断为远处转移性疾病虽然目前还没有治愈转移性乳腺癌的方法,但较新的全身疗法已经提高了生存率。Ixabepilone是一类非紫杉烷微管稳定剂,对紫杉烷耐药患者有活性。许多试验已经证明伊沙匹龙对化疗耐药肿瘤的疗效。3-5本研究评估了伊沙epilone的疗效,并在日常临床实践中比较了该药物在转移性乳腺癌患者中的两种方案。伊沙匹隆治疗转移性乳腺癌:真实世界的经验
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引用次数: 0
Multiple Primary Synchronous Gastric, Esophageal, and Rectal Cancer and Isolated Esophageal Metastasis from Rectal Cancer: Case Report 胃癌、食管癌、直肠癌多发原发同步及孤立性食管转移:1例报告
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/jos.2020-80507
G. Sönmez, A. Aytekin, R. Erten, M. Aldemir, A. Sakin, R. Esen
neoplasms identified simultaneously or within 6 months after the initial diagnosis in the same patient.1 However, synchronous tumors of the gastric and rectum carcinoma are not infrequent; particularly in the elderly male patient.2 The most commonly detected synchronous tumors in patients with gastric cancer are colorectal cancers, which are followed by lung, esophagus, and liver cancers.2 Rectal carcinoma commonly metastasizes to the liver, lungs, bone, brain, and lymph nodes.3 Esophageal metastasis of rectal carcinoma is an unusual occurrence owing to its rarity and challenges in diagnosis. Therefore, patients might be misdiagnosed sometimes and not be treated properly. Secondary carcinoma of the esophagus occurs as a result of the direct invasion, hematogenous, or lymphatic spread from the distant primary sites.4 Approximately 3.1-6.1% of patients who had died from any type of cancer in the autopsy series reported esophageal metastasis. Additionally, it has shown that the most common primary malignancies that metastasize to the esophagus are breast and lung cancers in the same autopsy series.3,5 Herein, we present the case of a 63-year-old man with synchronous gastric, rectal carcinoma, and in situ esophageal carcinoma who also had isolated esophageal metastasis from rectal carcinoma. J Oncol Sci. 2021;7(3):159-62
同一患者同时发现肿瘤或初次诊断后6个月内发现肿瘤然而,胃癌和直肠癌同时发生的肿瘤并不少见;尤其是老年男性患者胃癌患者同步肿瘤检出率最高的是结直肠癌,其次是肺癌、食管癌和肝癌直肠癌通常转移到肝、肺、骨、脑和淋巴结摘要直肠癌食管转移是一种罕见的疾病,其诊断难度大。因此,患者有时会被误诊,得不到适当的治疗。继发性食管癌的发生是由于远处原发灶的直接侵袭、血液或淋巴扩散的结果在尸检系列中,死于任何类型癌症的患者中约有3.1-6.1%报告有食管转移。此外,在同一尸检系列中,最常见的转移到食道的原发性恶性肿瘤是乳腺癌和肺癌。3,5在此,我们报告一位63岁男性,同时患有胃癌、直肠癌和原位食管癌,并有孤立的直肠癌食管转移。中华肿瘤学杂志,2011;7(3):159-62
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引用次数: 0
Comparison of Clinicopathological Characteristics of BRCA1 and BRCA2 Carriers with Breast Cancer: The Role of Ki-67 Index BRCA1和BRCA2携带者乳腺癌临床病理特征的比较:Ki-67指数的作用
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/jos.2021-81821
Recep Ak, C. Karaçin, T. Bahşi, Ö. B. Öksüzoğlu
91 One in 8 women in the community are predisposed to develop breast cancer, and this risk significantly escalates in women with a family history of breast carcinoma.1,2 Approximately, 10% of breast cancers are hereditary, and mutation in the breast cancer (BRCA) gene is one of the best-known mutations associated with breast cancer.2-5 The factors that increase the chances of a BRCA mutation in breast cancer include young age (<40 years), triple-negative tumors, male gender, family history, ovarian cancer, and bilateral breast cancer.6 Currently, BRCA mutations are evaluated in 2 subgroups, BRCA1 and BRCA2, and patients with BRCA mutations can develop secondary malignancies.
91社区中每8名妇女中就有1人易患乳腺癌,有乳腺癌家族史的妇女患乳腺癌的风险显著增加。大约10%的乳腺癌是遗传性的,而乳腺癌(BRCA)基因突变是与乳腺癌相关的最著名的突变之一。增加乳腺癌BRCA突变几率的因素包括年轻(<40岁)、三阴性肿瘤、男性、家族史、卵巢癌和双侧乳腺癌目前,BRCA突变被评估为2个亚组,BRCA1和BRCA2, BRCA突变患者可发展为继发性恶性肿瘤。
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引用次数: 0
Determining the Current Situation of Geriatric Oncology in Turkey: A Survey of Medical Oncologists 确定土耳其老年肿瘤的现状:一项医学肿瘤学家的调查
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/JOS.2020-80824
Baran Akagunduz, D. Guven, M. Atçı, I. Cil, C. Karaçin, Muhammet Ozer, S. Kılıçkap
cer patients is 70 years and above.1 Recently, the rising life expectancy in the general population coupled with a disproportionate cancer burden among individuals aged 70 years and older have enthralled considerable interest in ensuring improved cancer treatment for the geriatric population.2 Significant limitation persists regarding optimal cancer treatment for older patients. Unique challenges are witnessed in the management of geriatric cancer patients. A thorough examination of the older person’s health status can aid in the assessment of risks and benefits of cancer treatment, affect the choice and intensity of treatment, and guide supportive care strategies.3 The central domains of geriatric assessment (GA) include physical and cognitive function assessment, comorbid medical problems, diet, medications, and psychological conditions.4 Despite the recommendations of the International Society of Geriatric Oncology (SIOG) and the National Comprehensive Cancer Network (NCCN), time restrictions mostly impede the systematic implementation of the application of geriatric assessment in oncology practice.5,6 To collect data without the time commitment and stress on patients and caregivers, cancer-specific geriatric evaluation tools have been designed.7 Nevertheless, the implementation of geriatric evaluation in daily medical oncology practice remains elusive.
70岁及以上近年来,随着普通人群预期寿命的延长,加上70岁及以上人群的癌症负担不成比例,人们对确保改善老年人群的癌症治疗产生了相当大的兴趣对于老年患者的最佳癌症治疗仍然存在显著的局限性。老年癌症患者的管理面临着独特的挑战。对老年人健康状况的全面检查有助于评估癌症治疗的风险和益处,影响治疗的选择和强度,并指导支持性护理策略老年评估(GA)的核心领域包括身体和认知功能评估、共病医学问题、饮食、药物和心理状况尽管国际老年肿瘤学会(SIOG)和国家综合癌症网络(NCCN)提出了建议,但时间限制主要阻碍了肿瘤实践中老年评估应用的系统实施。5,6为了在没有时间承诺和患者和护理人员压力的情况下收集数据,设计了针对癌症的老年评估工具然而,在日常肿瘤医学实践中实施老年评估仍然难以捉摸。
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引用次数: 0
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Journal of Oncological Sciences
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