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Benefits of Neoadjuvant Chemotherapy for Luminal Breast Cancer with Respect to Tumor Response 新辅助化疗对腔内乳腺癌肿瘤反应的益处
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/JOS.2020-75852
Bala Başak Öven, S. Çelik, G. Gürleyik, F. Vardar, E. Çoban, M. Seker, I. Okten, A. Aktekin
aDepartment of Medical Oncology, Bahçeşehir University Medical Faculty, İstanbul, TURKEY bDepartment of General Surgery, Haydarpasa Numune Educartion and Research Hospital, İstanbul, TURKEY cDepartment of Pathology, Haydarpasa Numune Educartion and Research Hospital, İstanbul, TURKEY dDepartment of Medical Oncology, Bezmi Alem University, Medical Faculty, İstabul,TURKEY eDepartment of General Surgey Gaziantep University, Medical Faculty, Gaziantep, TURKEY
a巴哈佩尔伊希尔大学医学院肿瘤内科,İstanbul,土耳其;b海达尔帕萨努姆尼教育与研究医院普通外科,İstanbul,土耳其;c海达尔帕萨努姆尼教育与研究医院病理科,İstanbul,土耳其;d贝兹米阿莱姆大学医学院肿瘤内科,İstabul,土耳其加济安泰普大学医学院普通外科,加济安泰普,土耳其
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引用次数: 0
Subclinical Hypothyroidism in Patients with Newly Diagnosed Breast Cancer 新诊断乳腺癌患者的亚临床甲状腺功能减退
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/JOS.2020-79561
M. Kara, Oyku Beyaz, E. Koç, O. Sonmez
become the most common malignant disease, with two million new cases and more than 600,000 deaths in 2018, making it vital to identify the associated risk factors.1,2 Many earlier studies have attempted to assess an association between thyroid disease and breast cancer, but it is difficult to distinguish a cause-and-effect relationship between the two conditions despite their high prevalence in women.3 The relation between hypothyroidism and the risk of breast cancer was first published in 1976 by Kapdi and Wolfe, who observed a higher breast cancer incidence rate among patients undergoing thyroid supplement treatment.4 Since then, four metaanalyses have studied thyroid dysfunction and the risk of breast cancer.5-8 Angelousi et al. examined 12 studies and found no association between hypothyroidism and increased risk of breast cancer, five and further suggested that thyroid hormone replacement therapy did not reduce the prevalence of breast cancer. In a later metaanalysis, Fang et al. reported no relationship between thyroid dysfunction and risk of breast cancer, while Wang et al. found a reduced risk of breast cancer due to hypothyroidism in the European population.7,8
成为最常见的恶性疾病,2018年有200万新病例和60多万例死亡,因此确定相关风险因素至关重要。1,2许多早期的研究试图评估甲状腺疾病和乳腺癌之间的联系,但很难区分这两种疾病之间的因果关系,尽管它们在女性中发病率很高Kapdi和Wolfe于1976年首次发表了甲状腺功能减退症与乳腺癌风险之间的关系,他们观察到接受甲状腺补充治疗的患者乳腺癌发病率更高从那以后,有四项荟萃分析研究了甲状腺功能障碍和乳腺癌的风险。Angelousi等人检查了12项研究,发现甲状腺功能减退与乳腺癌风险增加之间没有关联,并进一步表明甲状腺激素替代疗法并没有降低乳腺癌的患病率。在后来的荟萃分析中,Fang等人报道甲状腺功能障碍与乳腺癌风险之间没有关系,而Wang等人发现欧洲人群中甲状腺功能减退导致乳腺癌风险降低7,8
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引用次数: 0
Pericatheter Fibrin Sheath Calcification Mimicking Retained Catheter Fragment 导管周围纤维蛋白鞘钙化模拟保留导管碎片
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/jos.2020-80449
F. Çay, G. Eldem, B. Peynircioğlu
(TIAPs) are reported to be safe and well-accepted among cancer patients.1 TIAPs are useful in the management of patients who require multiple chemotherapy sessions, parenteral nutrition, prolonged intravenous drug treatment (with antibiotics, etc.), and repeated drawing of blood. Moreover, chemotherapeutic agents are associated with less venous toxicity when administered via the central venous route. Most cases of TIAPs remain complication-free until treatment completion or death and present a complication rate of 19% during the entire duration of device usage.1 In the case report presented here, a rare complication of TIAPs-peri-catheter fibrin sheath calcification mimicking a retained catheter fragment-is described to increase the awareness of this condition among medical professionals.
据报道,TIAPs在癌症患者中是安全且被广泛接受的TIAPs对于需要多次化疗、肠外营养、长时间静脉药物治疗(抗生素等)和反复抽血的患者非常有用。此外,化疗药物通过中心静脉途径给药时,静脉毒性较小。大多数TIAPs病例在治疗完成或死亡前均无并发症,在整个装置使用期间并发症发生率为19%在这里的病例报告中,描述了一种罕见的tiaps并发症-导管周围纤维蛋白鞘钙化模拟导管碎片保留-以提高医学专业人员对这种情况的认识。
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引用次数: 0
Evaluation of Smoking Status of Cancer Patients Admitted to the Nuclear Medicine Department According to the Demographic Characteristics and Cancer Type 根据人口学特征和肿瘤类型对核医学住院肿瘤患者吸烟状况的评价
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.37047/jos.2021-84128
S. Göksel, D. Karadoğan
106 Smoking is still the most important cause of morbidity and mortality in Turkey and the world. Smoking is a severe problem in cancer patients and should be handled effectively. Studies have reported that cancer-specific mortality increases in cancer patients who continue smoking and that quitting smoking at any stage after diagnosis is beneficial in treatment outcomes, quality of life, and general survival of patients with cancer.1-5
106在土耳其和全世界,吸烟仍然是发病和死亡的最重要原因。吸烟对癌症患者来说是一个严重的问题,应该得到有效处理。有研究报道,继续吸烟的癌症患者的癌症特异性死亡率增加,在诊断后的任何阶段戒烟对治疗结果、生活质量和癌症患者的总体生存率都是有益的
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引用次数: 0
Sleep Quality of Cancer Patients Receiving Systemic Treatment: A Cross-Sectional Study 接受系统治疗的癌症患者睡眠质量:一项横断面研究
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-71898
N. Sanlier, M. Şahin, A. Demirkazık, Asiye Özkan, F. Senler
apeutics may lead to the development of various functional problems among the patients. Novel surgical procedures developed to protect organ function employ minimally invasive procedures. However, complex therapies including radiotherapy and chemotherapy are often provided to the patients. Multidisciplinary treatment approaches in cancer patients affect a number of functional fields including physical, psychosocial, and economic areas.1
Apeutics可能导致患者出现各种功能问题。采用微创手术保护器官功能的新型外科手术。然而,包括放疗和化疗在内的复杂治疗方法经常被提供给患者。癌症患者的多学科治疗方法影响到许多功能领域,包括身体、社会心理和经济领域
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引用次数: 5
Deciphering the Role of Combination Therapy of Cobimetinib, Vemurafenib, and Antidepressant Drugs in QTc Prolongation and Torsade De Pointes (TDP) in Malignant Melanoma 解读Cobimetinib, Vemurafenib和抗抑郁药物联合治疗在恶性黑色素瘤QTc延长和TDP中的作用
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-73730
A. Paudel, O. Mammadov, Özlem Sönmez
combination of MEK inhibitors (cobimetinib and trametinib), and BRAF inhibitors (vemurafenib and dabrafenib) is now considered as the first-line treatment of patients with BRAF V600-mutated metastatic melanoma. The common side-effects of BRAF inhibitors are cutaneous toxicity, nephrotoxicity, and cardiotoxicity.1 In a previous clinical study, the combined administration of vemurafenib and cobimetinib has been associated with cardiotoxicity (heart failure) and QTc prolongation, that persisted after the discontinuation of therapy but returned to normal after six months. The patient was discharged with an implantable intracardiac defibrillator (ICD) for safety.2 Most TKIs significantly increase the QT interval, while the incidence of arrhythmias was noted highest in vemurafenib.3 Additionally, vemurafenib might induce severe acute renal failure, including persistent renal injury.4 Though, the result from the previous clinical study which was based on 38 patients, showed that the adjunction of MEK inhibitor to vemurafenib in the treatment of metastatic melanoma reduces the incidence and severity of nephrotoxicity compared to monotherapy in a study of 38 patients, while a phase IB dose-escalation study of the cobimetinib and duligotuzumab showed that the 26% of the patients experienced hypokalemia, further indicating cobimetinib which might have some adverse effects on the renal tubular system.5,6 J Oncol Sci.2020;6(2):123-6
MEK抑制剂(cobimetinib和trametinib)和BRAF抑制剂(vemurafenib和dabrafenib)的联合治疗现在被认为是BRAF v600突变转移性黑色素瘤患者的一线治疗方法。BRAF抑制剂的常见副作用是皮肤毒性、肾毒性和心脏毒性在之前的一项临床研究中,vemurafenib和cobimetinib联合用药与心脏毒性(心力衰竭)和QTc延长有关,QTc延长在停药后持续存在,但在6个月后恢复正常。为安全起见,患者出院时已植入心脏内除颤器(ICD)大多数TKIs显著增加QT间期,而vemurafenib组心律失常发生率最高此外,vemurafenib可能引起严重的急性肾功能衰竭,包括持续性肾损伤然而,先前基于38例患者的临床研究结果显示,与38例患者的单药治疗相比,MEK抑制剂与vemurafenib联合治疗转移性黑色素瘤降低了肾毒性的发生率和严重程度,而cobimetinib和duligotuzumab的IB期剂量升级研究显示,26%的患者出现了低钾血症。进一步提示可比美替尼可能对肾小管系统有不良影响。[J] .中华肿瘤学杂志,2020;6(2):123-6
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引用次数: 1
Turkish Medical Oncology Society COVID-19 Pandemic Advisory Board Recommendations for Cancer Patients and Medical Oncologist 土耳其医学肿瘤学会COVID-19大流行咨询委员会对癌症患者和医学肿瘤学家的建议
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-75364
A. Sümbül, Ş. Yalçın, A. Özet, S. Ünal, O. Dizdar, H. Akbulut, A. Karaoglu, N. Karadurmuş, M. Şendur, E. Çılbır, F. Yıldız, G. Tufan, O. Sonmez, N. Turhal
monia in Wuhan province in China in December 2019 and later caused a pandemic in the whole world, is a serious threat to all humans and particularly, the oncology patients.1 With the diagnosis of the first case in our country and the declaration by WHO of COVID19 as a global pandemic on March 11, 2020, a new phase of the process has begun. WHO particularly emphasizes the preparedness, prevention, case detection, treatment, and reduction of transmission related to the basic strategies of the disease.2 Cancer patients are at high mortality risk due to coronavirus infection because of age, comorbid conditions, and current use of immunosuppressive treatment protocols.
1 . 2019年12月在中国武汉发生并随后在全球范围内引起大流行的肺炎疫情,对全人类特别是肿瘤患者构成了严重威胁随着2020年3月11日我国确诊首例病例以及世卫组织宣布covid - 19为全球大流行,这一进程进入了一个新阶段。世卫组织特别强调与该疾病的基本战略有关的防备、预防、病例发现、治疗和减少传播由于年龄、合并症和目前使用的免疫抑制治疗方案,癌症患者因冠状病毒感染而死亡的风险很高。
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引用次数: 4
Optimal Cytoreduction is an Independent Prognostic Factor in Ovarian Carcinosarcoma: A Turkish Gynecologic Oncology Group Study 最佳细胞减少是卵巢癌肉瘤的独立预后因素:土耳其妇科肿瘤组研究
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-73073
A. Ayhan, I. Çiçin, A. Gökyer, M. Sarı, A. Turan, S. Taşkın, K. Gungorduk, O. Akbayir, P. Saip, H. Şahin, G. Çoban, S. Topuz, I. Selcuk, G. Tulunay, M. Meydanlı
78 Ovarian carcinosarcoma (OCS), accounting for only 1-4% of all ovarian malignancies, is a rare neoplasm characterized by sarcomatous and epithelial elements.1-3 Some authors have proposed that OCSs originate from the müllerian epithelium and then differentiation/metaplasia to a sarcomatous structure, supporting the hypothesis that OCS is a metaplastic epithelial carcinoma.4-6 OCS is highly aggressive and has a poor prognosis, presenting with a disease that has spread beyond the ovary in up to 90% of cases at Optimal Cytoreduction is an Independent Prognostic Factor in Ovarian Carcinosarcoma: A Turkish Gynecologic Oncology Group Study
卵巢癌肉瘤(OCS)是一种罕见的肿瘤,以肉瘤和上皮成分为特征,仅占所有卵巢恶性肿瘤的1-4%。1-3一些作者提出OCS起源于勒氏上皮,然后分化/化生为肉瘤结构,支持OCS是一种化生上皮癌的假设。4-6 OCS具有高度侵袭性,预后差,在高达90%的病例中表现为疾病已扩散到卵巢以外:最佳细胞减少是卵巢癌肉瘤的独立预后因素:一项土耳其妇科肿瘤小组研究
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引用次数: 0
Epidemiology of Lung Cancer in Women: A Hospital-Based Descriptive Study 女性肺癌流行病学:一项基于医院的描述性研究
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-73409
Ö. Er, Didem Saka, Elif Özuğuz
Lung cancer, which was described as “one of the rarest forms of cancer” in 1912 before the introduction of cigarettes, was the most common diagnosed cancer in 2018 (2.1 million, 11.6% of the total). Lung cancer needs to be considered as it is the most common cause of death (1.8 million, 18.4% of the total).1 Although several developed nations now have declining rates of lung cancer, the incidence and mortality rates among women have increased in several western countries. Although the incidence of lung cancer decreased among men, an increasing pattern was noted among women, which was associated with increased smoking rates after the second J Oncol Sci.2020;6(1):29-34
在香烟引入之前,肺癌在1912年被描述为“最罕见的癌症之一”,在2018年是最常见的诊断癌症(210万例,占总数的11.6%)。需要考虑肺癌,因为它是最常见的死亡原因(180万,占总数的18.4%)尽管一些发达国家的肺癌发病率正在下降,但在一些西方国家,妇女的发病率和死亡率却有所上升。尽管男性肺癌发病率下降,但女性发病率呈上升趋势,这与第二次肺癌后吸烟率上升有关[J] .中国癌症杂志,2020;6(1):29-34
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引用次数: 0
The Impact of Loneliness and Cancer Diagnosis on Cognitive Impairment in Geriatric Patients 孤独感与癌症诊断对老年患者认知功能障碍的影响
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-71889
A. Alkan, H. S. Öztorun, E. Karci, Y. Urun, G. Tuncay, A. Yaşar, E. Çınar, S. Aras, M. Varlı, G. Utkan, A. Demirkazık, H. Akbulut, F. Senler
experience or feeling that results from inadequacies in personal or social requirements. It principally originates from differences between the desired and actual social relations.1 Its prevalence increases linearly with age, and thus, is found in up to 50% of geriatric patients.2 Geriatric patients are more exposed to loneliness; hence, this subject has been studied more extensively in the geriatric patient group. Female geriatric patients have been documented to be at higher risk of loneliness due to factors such as being single/widowed, older age, low educational status, low household income, living alone, decreased quality of social interactions, poor health, and decreased functional status.3 In addition, the presence of depression has been associated with increased loneliness.4,5 Studies on the clinical effects of loneliness on geriatric patients have shown that loneliness is associated with mental health issues, reduced sleep quality, decreased quality of life, increased hospitalizations, and increased mortality.6-9 In addition, loneliness has been associated with cognitive dysfunction and Alzheimer’s disease.10-13 J Oncol Sci.2020;6(2):65-70
因个人或社会需求不足而产生的经验或感觉。它主要源于期望的社会关系和实际的社会关系之间的差异其患病率随着年龄的增长呈线性增长,因此,在高达50%的老年患者中发现老年患者更容易感到孤独;因此,这一课题在老年患者群体中得到了更广泛的研究。女性老年患者由于单身/丧偶、年龄较大、受教育程度低、家庭收入低、独居、社会交往质量下降、健康状况不佳和功能状态下降等因素,孤独感风险较高此外,抑郁症的存在与孤独感的增加有关。4,5孤独感对老年患者临床影响的研究表明,孤独感与心理健康问题、睡眠质量下降、生活质量下降、住院率上升和死亡率上升有关。此外,孤独与认知功能障碍和阿尔茨海默病有关。中国生物医学工程学报,2020;6(2):65-70
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引用次数: 0
期刊
Journal of Oncological Sciences
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