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A Real-World Comparison of Pazopanib Versus Sunitinib in Metastatic Renal Cell Carcinoma: Focus on Poor-Risk patients, A Single-Center Study Pazopanib和舒尼替尼在转移性肾细胞癌中的实际比较:一项单中心研究,重点是低风险患者
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-76764
L. Demir, Duygu Bayır, Ruhengiz Özdoğan, B. Yıldız, M. Dinçer
The Memorial Sloan Kettering Cancer Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) have classified RCC according to clinical characteristics into three risk groups: favorable, intermediate, and poor. Previous reports have demonstrated that patients with poor-risk features (according to MSKCC criteria and neutrophil and platelet counts) presented a significantly shorter overall survival (OS) than patients with favorableto intermediate-risk features, and the twoyear survival rate of poor-risk patients did not exceed 7%, while that of the favorableto intermediate-risk patients was 53-75%.4,5
纪念斯隆凯特琳癌症中心(MSKCC)和国际转移性肾细胞癌数据库联盟(IMDC)根据临床特征将肾细胞癌分为三个风险组:有利、中等和不良。既往报道显示,低危患者(根据MSKCC标准及中性粒细胞和血小板计数)的总生存期(OS)明显短于有利至中危患者,低危患者的两年生存率不超过7%,而有利至中危患者的两年生存率为53-75%。4,5
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引用次数: 0
Third-line Therapy for Metastatic Renal Cell Carcinoma and Its Effect on Quality of Life and Overall Survival: A National, Multicenter, Observational Study 转移性肾细胞癌三线治疗及其对生活质量和总体生存的影响:一项全国性、多中心、观察性研究
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-75080
I. Çiçin, Aydın Çiltaş, S. Kılıçkap, B. Öksüzoğlu, D. Uncu, M. Artaç, H. Çınkır, A. Işıkdoğan, F. Dane, M. Aliustaoğlu, H. M. Türk, E. Elkiran, E. Çubukçu, M. Ekenel, F. Ozdemir, A. Gökyer, I. Oztop, A. Alacacıoğlu, Hüseyin Öztürk, B. Aver, M. Ozkan
aTrakya University Faculty of Medicine, Department of Internal Medicine, Division of Oncology, Edirne, TURKEY bGazi University Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, Ankara, TURKEY cHacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, Ankara, TURKEY dDr. Abdurrahman Yurtarslan Ankara Oncology Training and Research Hospital, Department of Internal Medicine, Division of Medical Oncology, Ankara, TURKEY eUniversiy of Health Sciences Ankara Numune Training and Research Hospital, Clinic of Medical Oncology, Ankara, TURKEY fNecmettin Erbakan University Meram Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, Konya, TURKEY gGaziantep University Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, Gaziantep, TURKEY hDicle University Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, Diyarbakır, TURKEY iMarmara University Pendik Training and Research Hospital, Department of Internal Medicine, Division of Medical Oncology, İstanbul, TURKEY jKartal Dr. Lütfi Kirdar Training and Research Hospital, Department of Medical Oncology, İstanbul, TURKEY kBezmialem Vakıf University Faculty of Medicine, Department of Medical Oncology, İstanbul, TURKEY lİnönü University Turgut Ozal Medical Center, Department of Internal Medicine, Division of Medical Oncology, Malatya, TURKEY mAli Osman Sönmez Oncology Hospital, Department of Medical Oncology, Bursa, TURKEY nİstanbul University Istanbul Medical Faculty, Department of Medical Oncology, İstanbul, TURKEY oKaradeniz Technical University Faculty of Medicine, Department of Internal Medicine, Trabzon, TURKEY pDokuz Eylül University Faculty of Medicine, Department of Medical Oncology, İzmir, TURKEY rIzmir Katip Çelebi University Atatürk Training and Research Hospital, Department of Medical Oncology, İzmir, TURKEY sPfizer Pharmaceuticals, Medical Oncology Department, İstanbul, TURKEY tErciyes University Faculty of Medicine, Department of Internal Medicine, Kayseri, TURKEY
土耳其埃迪尔内,阿特拉基亚大学医学院,内科内科,肿瘤科;土耳其安卡拉,加齐大学医学院,内科内科,肿瘤科;土耳其,安卡拉,恰特佩普大学医学院,内科内科,肿瘤科;Abdurrahman Yurtarslan土耳其安卡拉肿瘤培训和研究医院内科内科肿瘤科土耳其安卡拉健康科学大学安卡拉Numune肿瘤内科培训和研究医院土耳其安卡拉内科肿瘤科土耳其加济安泰普大学医学院内科内科内科土耳其加济安泰普大学医学院肿瘤科内科肿瘤科Diyarbakır,土耳其伊马尔马拉大学潘迪克培训和研究医院内科肿瘤科İstanbul,土耳其伊马尔马拉大学内科内科肿瘤科İstanbul,土耳其贝兹米阿勒姆Vakıf大学医学院肿瘤科İstanbul,土耳其lİnönü土耳其马拉提亚图尔古特·奥扎尔大学医学中心,内科内科,肿瘤内科,马里·奥斯曼Sönmez土耳其布尔萨肿瘤医院,肿瘤内科,nİstanbul伊斯坦布尔大学医学院,肿瘤内科,İstanbul,土耳其奥卡拉德尼兹技术大学医学院,内科,特拉布松,土耳其pDokuz eyll大学医学院,肿瘤内科,土耳其İzmir,土耳其rIzmir Katip Çelebi土耳其atatrk大学培训与研究医院,肿瘤内科,İzmir,土耳其sPfizer制药,肿瘤内科,İstanbul,土耳其tErciyes大学医学院,内科,开塞利,土耳其
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引用次数: 2
Pituitary Gland Metastasis of Breast Cancer: A Rare Case Report and Review of the Literature 乳腺癌垂体转移一例罕见病例报告及文献复习
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-75309
M. Şimşek
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引用次数: 2
Docetaxel, Cisplatin, and Fluorouracil Combination Chemotherapy in Neoadjuvant Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: A Retrospective Study 多西紫杉醇、顺铂和氟尿嘧啶联合化疗在局部晚期食管鳞状细胞癌新辅助治疗中的回顾性研究
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-76836
Öztürk Ateş, E. Yekedüz, S. Kılıçkap, Ş. Yalçın
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引用次数: 1
The Comparison of Central Venous Port Catheters in Gastrointestinal Cancer Treatment 中心静脉端口导管在胃肠道肿瘤治疗中的比较
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-73122
I. Beypınar, H. Demir, M. Araz, D. Beypinar, M. Uysal
10 The infusional chemotherapy regimen, especially in gastrointestinal cancers, has a long-term need for central venous catheterization. Implantable ports (IP) are increasingly used for the administration of chemotherapy and supportive treatment to cancer patients. The IPs may be complicated with thrombosis in both upper and lower extremities, during placement or long-term follow-up which is associated with treatment delay, increasing financial burden, morbidity and mortality.1-6 IP thrombosis is mostly seen in the first three months and rarely seen beyond this period. The most preferred location for IPs is the subclavian vein, which is implanted by the Seldinger technique via a cephalic vein.7 In appropriate patients, femoral IPs can also be used.8 The main cause of thrombosis is considered to be direct vascular damage.4,9,10 There are mainly three mechanisms of IP thrombosis. The first mechanism is an acute reaction of clotting, which is induced with a fibrin sheath and is related to the subsequent risk of thrombosis. The second mechanism is the lumen thrombosis of the catheter, which may be thawed with thrombolytic agents. Blood vessel thrombosis is the most severe The Comparison of Central Venous Port Catheters in Gastrointestinal Cancer Treatment
输注化疗方案,特别是胃肠道肿瘤,长期需要中心静脉置管。植入式端口(IP)越来越多地用于癌症患者的化疗和支持治疗。在放置或长期随访期间,IPs可能并发上肢和下肢血栓形成,这与治疗延迟、经济负担增加、发病率和死亡率相关。1-6 IP血栓形成多见于前三个月,很少见于此之后。植入IPs的最佳位置是锁骨下静脉,采用Seldinger技术通过头静脉植入在适当的患者中,也可以使用股骨ip血栓形成的主要原因被认为是血管的直接损伤。4,9,10 IP血栓形成的机制主要有三种。第一种机制是由纤维蛋白鞘诱导的急性凝血反应,与随后的血栓形成风险有关。第二种机制是导管的管腔血栓形成,可以用溶栓剂解冻。血管血栓是最严重的。中心静脉端口导管在胃肠道肿瘤治疗中的比较
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引用次数: 0
Multimodality Treatment in Malignant Peripheral Nerve Sheath Tumors 恶性周围神经鞘肿瘤的综合治疗
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-73127
Y. Karakaş, O. Dizdar, K. Kösemehmetoğlu, U. B. Bozbulut, Metin Demir, G. Gedıkoğlu, F. Söylemezoğlu, A. Turker, A. Kars
Malignant peripheral nerve sheath tumor (MPNST) is an uncommon soft tissue sarcoma that originates from the peripheral nerves and is hypothesized to be of neural crest origin.1 The incidence of MPNST is 1:100.000/year and accounts for 5-10% of all soft tissue sarcomas.2 Approximately 50% of MPNSTs occur sporadically, the remaining arises secondary to prior radiation exposure and in patients with neurofibromatosis type 1 (NF1).3-5 In the NF1 patients, MPNST usually originates from plexiform neurofibromas and atypical neurofibromas. The lifetime risk of developing MPNST in these patients is around 8-13%.5-8 MPNSTs often arise from large and medium-sized nerves, located in the extremities in 33J Oncol Sci. 2020;6(1):23-8
恶性周围神经鞘瘤(MPNST)是一种罕见的软组织肉瘤,起源于周围神经,假设起源于神经嵴MPNST的发病率为1:10万/年,占所有软组织肉瘤的5-10%大约50%的mpnst是偶发的,其余的继发于先前的辐射暴露和1型神经纤维瘤病(NF1)患者。在NF1患者中,MPNST通常起源于丛状神经纤维瘤和非典型神经纤维瘤。这些患者发生MPNST的终生风险约为8-13%。5-8 mpnst多发生于四肢的大中型神经[j] .中华肿瘤杂志,2020;6(1):23-8
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引用次数: 1
Radiotherapy-Related Dural Sarcoma and Its Management: Case Report 放疗相关硬脑膜肉瘤及其治疗:1例报告
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2020-76458
M. Gürbüz, P. K. Tolunay, E. Akkuş, Ümit Eroğlu, A. Heper, F. Senler
Sarcomas are malignant neoplasms that arise from mesenchymal tissues. Sarcomas are a rare type of solid cancers, encompassing more than one hundred subtypes, and occur at any age.1 Sarcomas of the meninges may originate primarily from mesenchymal cells or may be metastases of extracranial soft tissue sarcomas.2 Symptoms such as nausea, vomiting, headache, seizure, and spinal cord compression may occur depending on the size and location of the tumor. Cranial magnetic resonance imaging (MRI) is often used for diagnosis. The primary treatment for sarcomas is surgery; other treatment options include radiotherapy (RT), chemotherapy (CT), targeted therapies, and immunotherapy.3 Though RT is one of the risk factors for sarcoma development, RT-related dural sarcomas are extremely rare.2 There is no consensus on the management of these extremely rare, malignant neoplasms. Here, the authors report a case of RT-related dural sarcoma and its management.
肉瘤是发生于间质组织的恶性肿瘤。肉瘤是一种罕见的实体癌,包括一百多种亚型,可发生于任何年龄脑膜肉瘤可能主要起源于间充质细胞,也可能是颅外软组织肉瘤的转移灶根据肿瘤的大小和位置不同,可能出现恶心、呕吐、头痛、癫痫发作和脊髓压迫等症状。颅磁共振成像(MRI)常用于诊断。肉瘤的主要治疗方法是手术;其他治疗方案包括放疗(RT)、化疗(CT)、靶向治疗和免疫治疗虽然放疗是肉瘤发生的危险因素之一,但与放疗相关的硬脑膜肉瘤极为罕见对于这些极其罕见的恶性肿瘤的治疗尚无共识。在这里,作者报告了一例与rt相关的硬脑膜肉瘤及其治疗。
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引用次数: 0
Vismodegib for Patients with Advanced Basal Cell Carcinoma: One Center’s Experience 维莫替吉治疗晚期基底细胞癌:一个中心的经验
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-71992
H. Çınkır, O. Sever, F. Teker
atinocytes located in the basal epidermis, which firstly infiltrate the epidermis and then the dermis. Clinically, it usually occurs on the face and neck.1,2 BCC has five main clinical variants: nodular-ulcerative, superficial, sclerosing-morphea, pigment-ulcerated and fibroepithelial.3 The incidence rate of BCCs in the US reportedly spiked by 145% between 2000 and 2010 with the reasons for this significant increase including the aging of the patient population, increased awareness of the overall population, increased number of surgical cases, better record-keeping, and UV radiation.4
淋巴细胞位于基底表皮,先向表皮浸润,后向真皮层浸润。临床上,它通常发生在面部和颈部。BCC有五种主要的临床变异:结节性溃疡、浅表性、硬化性morphea、色素性溃疡和纤维上皮性据报道,2000年至2010年间,美国bcc的发病率飙升了145%,其显著增长的原因包括患者人口的老龄化、对总体人口的认识提高、手术病例数量增加、更好的记录保存和紫外线辐射
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引用次数: 2
Relationship Between Xanthine Oxidoreductase Activity and BRCA1 Levels in Patients with Stage IIIA and IIIB Non-Small Cell Lung Cancer Being Treated with Neoadjuvant Chemotherapy 接受新辅助化疗的IIIA期和IIIB期非小细胞肺癌患者黄嘌呤氧化还原酶活性与BRCA1水平的关系
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-71890
S. Yalçın, A. Sezer, A. Sümbül, Samet Rahatli, Ö. Altundağ, A. M. Sedef, O. Ozyılkan
Many biomarkers have emerged as prognostic and predictive markers for NSCLC. Among them, the common biomarkers are the epidermal growth factor receptor (EGFR), 5 endonuclease enzyme of nucleotide excision repair (ERCC1), Kirsten sarcoma virus, which is a proto-oncogene (K-ras), and regulator subunit of ribonucleotide reductase. Besides, there is huge evidence suggesting that there might be a prognosis between NSCLC and BRCA1, XOR.1-3
许多生物标志物已成为非小细胞肺癌的预后和预测标志物。其中,常见的生物标志物有表皮生长因子受体(EGFR)、核苷酸切除修复5内切酶(ERCC1)、原癌基因Kirsten肉瘤病毒(K-ras)、核糖核苷酸还原酶调节亚基。此外,大量证据表明,NSCLC与BRCA1、xor之间可能存在预后差异
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引用次数: 0
Stem Cells and Psyche: Perspectives and a Review of the Literature 干细胞和心理:观点和文献综述
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.37047/jos.2019-71899
H. Kumbasar, B. Duman, M. Yuksel, S. Bozdağ, Pelin Kilic, Acelya Yilmazer Aktuna, C. Gurcan, Tuğba Şen, Ç. Aydemir, D. Öztop, A. Uslu, G. Gurman
familiar, they indicate an advanced healthcare approach. In the 20th century, bone marrow transplantation exhibited a high expectation in the medical community and had immense popularity in society ever since. In clinical practice, the designation of “bone marrow transplantation” has been replaced with “stem cell transplantation, when stem cell sources other than bone marrow were discovered. Within the past 30 years, Ankara University Stem Cell Transplantation Unit executed around 3000 stem cell transplants.
熟悉,它们表明了一种先进的医疗方法。在20世纪,骨髓移植在医学界表现出很高的期望,从此在社会上得到了极大的普及。在临床实践中,当发现骨髓以外的干细胞来源时,“骨髓移植”的名称已被“干细胞移植”所取代。在过去的30年里,安卡拉大学干细胞移植中心实施了大约3000例干细胞移植。
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引用次数: 1
期刊
Journal of Oncological Sciences
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