Cancer is one of the causes of 6 major deaths in the world besides HIV, malaria, and tuberculosis. The incidence of liver cancer cases in 2018 reached 841 thousand, where there were 782 deaths. Modern medicine such as surgery, radiation, and chemotherapy has various drawbacks, high side effects, therapeutics failure, and high costs. Therefore, WHO recommends herbal medicine as a complementary therapy for various diseases, one of which is cancer. Sambiloto is one of the herbal plants that has been widely used by the people of Indonesia. The potential efficacy of sambiloto as a prospective herbal plant has been widely proven both through in vitro and in vivo studies. This study aims to determine the cytotoxic activity and IC50 value of polar, semipolar, and non-polar fractions of sambiloto leaves on HepG2 cells. Each fraction was tested for its cytotoxic activity against HepG2 cells with a concentration of 500; 250; 125; 62.5; 31.25; and 15,625 µg/mL using the MTT method. The results showed that the IC50 value for the polar, semipolar, and non-polar fractions was 82.585; 53,154; 614,349 µg / mL. Based on these results, the ethyl acetate and ethanol fractions of sambiloto leaves had strong cytotoxic activity against HepG2 cells.
{"title":"Uji Aktivitas Sitotoksik Ekstrak Polar, Semipolar, dan Non-Polar Daun Sambiloto (Andrographis paniculata) terhadap Sel Kanker Hati (HepG2)","authors":"Andzar Fikranus Shofa, Tunas Alam, Nuralih Nuralih","doi":"10.22435/jki.v0i0.4875","DOIUrl":"https://doi.org/10.22435/jki.v0i0.4875","url":null,"abstract":"Cancer is one of the causes of 6 major deaths in the world besides HIV, malaria, and tuberculosis. The incidence of liver cancer cases in 2018 reached 841 thousand, where there were 782 deaths. Modern medicine such as surgery, radiation, and chemotherapy has various drawbacks, high side effects, therapeutics failure, and high costs. Therefore, WHO recommends herbal medicine as a complementary therapy for various diseases, one of which is cancer. Sambiloto is one of the herbal plants that has been widely used by the people of Indonesia. The potential efficacy of sambiloto as a prospective herbal plant has been widely proven both through in vitro and in vivo studies. This study aims to determine the cytotoxic activity and IC50 value of polar, semipolar, and non-polar fractions of sambiloto leaves on HepG2 cells. Each fraction was tested for its cytotoxic activity against HepG2 cells with a concentration of 500; 250; 125; 62.5; 31.25; and 15,625 µg/mL using the MTT method. The results showed that the IC50 value for the polar, semipolar, and non-polar fractions was 82.585; 53,154; 614,349 µg / mL. Based on these results, the ethyl acetate and ethanol fractions of sambiloto leaves had strong cytotoxic activity against HepG2 cells.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47035907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Compounding plants into health ingredients is a promotive-preventive-based health culture, which was identified in the Research on Medicinal Plants and Herbs (Ristoja). The regeneration of traditional healers who mastered herbal formulation is not going well, documentation must be carried out for better knowledge transfer process. This study documented the traditional use of plants to preserve health and fatigue, using data from Ristoja 2012, 2015 and 2017, obtained from the National Institute of Health Research and Development (Indonesian Ministry of Health), data were analyzed descriptively. The data inventory includes grouping of species-family, plant parts, method, frequency, and duration of use, cultivation/non-cultivation, origin, and method of obtaining plants. The results show that the ingredients to preserve health and relieve fatigue have a large diversification, namely 33 families and 60 species. The most widely used are from families Zingiberaceae and Myrtaceae; species Z. officinale, C. domestica, C. xanthorrhiza, P. guajava, S. aromaticum, and S. Polyantum; parts of plant leaves (71,7%) and roots (38,3%;, originally from yards, forests, and fields/gardens; mostly consumed once/day (76,7%). Plants that have been used as ingredients to preserve health and relieve fatigue have several mechanism of action, such as antioxidant, anti-inflammatory, analgesic, glycemic control, blood pressure control, and others.
{"title":"Eksplorasi Tumbuhan Obat Indonesia untuk Kebugaran: Analisis Data Riset Tumbuhan Obat dan Jamu Tahun 2012, 2015, dan 2017","authors":"Lusi Kristiana, Astridya Paramita, Herti Maryani, Pramita Andarwati","doi":"10.22435/jki.v0i0.5209","DOIUrl":"https://doi.org/10.22435/jki.v0i0.5209","url":null,"abstract":"Compounding plants into health ingredients is a promotive-preventive-based health culture, which was identified in the Research on Medicinal Plants and Herbs (Ristoja). The regeneration of traditional healers who mastered herbal formulation is not going well, documentation must be carried out for better knowledge transfer process. This study documented the traditional use of plants to preserve health and fatigue, using data from Ristoja 2012, 2015 and 2017, obtained from the National Institute of Health Research and Development (Indonesian Ministry of Health), data were analyzed descriptively. The data inventory includes grouping of species-family, plant parts, method, frequency, and duration of use, cultivation/non-cultivation, origin, and method of obtaining plants. The results show that the ingredients to preserve health and relieve fatigue have a large diversification, namely 33 families and 60 species. The most widely used are from families Zingiberaceae and Myrtaceae; species Z. officinale, C. domestica, C. xanthorrhiza, P. guajava, S. aromaticum, and S. Polyantum; parts of plant leaves (71,7%) and roots (38,3%;, originally from yards, forests, and fields/gardens; mostly consumed once/day (76,7%). Plants that have been used as ingredients to preserve health and relieve fatigue have several mechanism of action, such as antioxidant, anti-inflammatory, analgesic, glycemic control, blood pressure control, and others.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43183903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Potassium Azeloyl Diglycinate is an innovative molecule that active as a skin hydrating, brightening agent, and treating skin hyperpigmentation. Facial Wash with foam stabilizing agents called surfactants is a facial cleansing soap that used daily to clean dirt and oil on the face. Iselux ultra mild surfactant as a mild surfactant has a low irritation profile, stable to pH and has a soft and abundant foam. This research is an experimental study. Formulating a good Hydrating Facial Wash Potassium azeloyl diglycinate with the addition of of Iselux ultra mild surfactants in various concentration, according to physical and chemical characteristics as well as a facial wash hydration test. Researchers used various concentration of 28: 30: 32% Iselux Ultra Mild for 3 types of formulas. The test results were analyzed by one way ANOVA. The results of testing the characteristics of physical and chemical properties including organoleptic tests, homogeneity, spreadability, foam height, viscosity, and pH as well as hydration evaluation showed that the facial wash was not change during storage for 12 days using the cycling test method. Formula 3 with the highest surfactant concentration met the best qualification on the parameters compared to Formula 1 and Formula 2. The hydration activity test based on the results of the pre and post test showed that the Facial Wash Potassium azeloyl diglycinate had moisturizing activity on the face.
{"title":"Pengaruh Variasi Konsentrasi Surfaktan Iselux Ultra Mild pada Formulasi Hydrating Facial Wash Potassium Azeloyl Diglycinate","authors":"Sholichah Rohmani, Sonia Karunia Ningrum, Wening Dyah Wardhani, Wisnu Kundarto","doi":"10.22435/jki.v0i0.4969","DOIUrl":"https://doi.org/10.22435/jki.v0i0.4969","url":null,"abstract":"Potassium Azeloyl Diglycinate is an innovative molecule that active as a skin hydrating, brightening agent, and treating skin hyperpigmentation. Facial Wash with foam stabilizing agents called surfactants is a facial cleansing soap that used daily to clean dirt and oil on the face. Iselux ultra mild surfactant as a mild surfactant has a low irritation profile, stable to pH and has a soft and abundant foam. This research is an experimental study. Formulating a good Hydrating Facial Wash Potassium azeloyl diglycinate with the addition of of Iselux ultra mild surfactants in various concentration, according to physical and chemical characteristics as well as a facial wash hydration test. Researchers used various concentration of 28: 30: 32% Iselux Ultra Mild for 3 types of formulas. The test results were analyzed by one way ANOVA. The results of testing the characteristics of physical and chemical properties including organoleptic tests, homogeneity, spreadability, foam height, viscosity, and pH as well as hydration evaluation showed that the facial wash was not change during storage for 12 days using the cycling test method. Formula 3 with the highest surfactant concentration met the best qualification on the parameters compared to Formula 1 and Formula 2. The hydration activity test based on the results of the pre and post test showed that the Facial Wash Potassium azeloyl diglycinate had moisturizing activity on the face.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45070744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Indarto, Taufik Isnanto, Farida Muyassaroh, Imelda Putri
Indonesia is a tropical country with high intensity of sunlight. Exposure to high ultraviolet rays from sunlight on the skin for a long period of time brings negative impacts such as sunburn, erythema, and skin cancer. Counteracting the negative effects of sun exposure, natural sunscreens that are less toxic such as combination of Cinnamomum burmannii and Haematococcus pluvialis extracts are needed. Cinnamaldehyde as the high active compound in cinnamon extract is able to absorb UV-B rays due to a chromophore group in the form of an aromatic ring conjugated to carbonyl group, along astaxanthin content in the Haematococcus pluvialis which is able to ward off free radicals and has an anti-inflammatory function that the combination will be an effective sunscreen active ingredients. The study aims to develop an oil-in-the-water emulsion-type cream that is added as an active ingredient in a combination of Haematococcus pluvialis and Cinnamomum burmannii extracts to produce a sunscreen cream. The combination extracts was tested in vitro with a UV-Vis spectrophotometer and the SPF value. The cream was physically evaluated including homogeneity, spreadability, adhesion, viscosity, pH, and organoleptic tests as well as in vivo test using mice (Mus muculus). The results indicated that the cream formulas qualified for the physical standards, yet the viscosity value unqualified the standard . The in vitro test showed that the highest SPF value reached SPF 12 for the S2 formula with maximum category. In vivo test showed that the entire formula could protect the skin from exposure to UV-B rays by exoterra lamps.
{"title":"Efektivitas Kombinasi Ekstrak Kayu Manis (Cinnamomum burmannii) dan Mikroalga (Haematococcus pluvialis) sebagai Krim Tabir Surya: Formulasi, Uji In Vitro, dan In Vivo","authors":"I. Indarto, Taufik Isnanto, Farida Muyassaroh, Imelda Putri","doi":"10.22435/jki.v0i0.5085","DOIUrl":"https://doi.org/10.22435/jki.v0i0.5085","url":null,"abstract":"Indonesia is a tropical country with high intensity of sunlight. Exposure to high ultraviolet rays from sunlight on the skin for a long period of time brings negative impacts such as sunburn, erythema, and skin cancer. Counteracting the negative effects of sun exposure, natural sunscreens that are less toxic such as combination of Cinnamomum burmannii and Haematococcus pluvialis extracts are needed. Cinnamaldehyde as the high active compound in cinnamon extract is able to absorb UV-B rays due to a chromophore group in the form of an aromatic ring conjugated to carbonyl group, along astaxanthin content in the Haematococcus pluvialis which is able to ward off free radicals and has an anti-inflammatory function that the combination will be an effective sunscreen active ingredients. The study aims to develop an oil-in-the-water emulsion-type cream that is added as an active ingredient in a combination of Haematococcus pluvialis and Cinnamomum burmannii extracts to produce a sunscreen cream. The combination extracts was tested in vitro with a UV-Vis spectrophotometer and the SPF value. The cream was physically evaluated including homogeneity, spreadability, adhesion, viscosity, pH, and organoleptic tests as well as in vivo test using mice (Mus muculus). The results indicated that the cream formulas qualified for the physical standards, yet the viscosity value unqualified the standard . The in vitro test showed that the highest SPF value reached SPF 12 for the S2 formula with maximum category. In vivo test showed that the entire formula could protect the skin from exposure to UV-B rays by exoterra lamps.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42518498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Ismaya, R. Pratiwi, Fenita Purnama Sari Indah, Gina Aulia, S. Sumarwati
Pharmacies are an inseparable part of the drug distribution chain until it reaches the patient. However, patients often hear complaints about the availability of drugs in pharmacies because sometimes there are drug shortage. The aim of this study was to identify the drug procurement pattern in four network pharmacies in the Bumi Serpong Damai (BSD) area in 2019. A retrospective study of four network pharmacies in the Bumi Serpong Peace (BSD) area of South Tangerang was carried out. A total of 8,959 samples were obtained by census from procurement documents of all drugs sold beginning in 2019. (A, B, C, and D pharmacies). The ABC and VEN methods were used in this study. The information gathered includes the name of the drug, the unit, the manufacturer's name, the creditor's name, and the amount and selling price. During 2019, four pharmacies had a total of 2,876 medicinal items of pharmacy A, 1,918 medicinal items of pharmacy B, 1,939 medicinal items of pharmacy C, and 2,226 medicinal items of pharmacy D, with a total drug expenditure of pharmacy A Rp.2,649,438;pharmacy B Rp.683,389,661; pharmacy C Rp. 881,540,329; and pharmacy D Rp. 1,245,520,143. Based on the findings of the study, it is possible to conclude that the four pharmacies have the most drugs in the essential category based on the VEN analysis. However, based on the Pareto ABC analysis, there are still many drugs in four network pharmacies in the BSD Region that fall into the Pareto C category, necessitating further investigation of the procurement.
{"title":"Pola Pengadaan Obat di 4 Apotek Jaringan Wilayah Bumi Serpong Damai (BSD) Tangerang Selatan","authors":"N. Ismaya, R. Pratiwi, Fenita Purnama Sari Indah, Gina Aulia, S. Sumarwati","doi":"10.22435/jki.v0i0.4937","DOIUrl":"https://doi.org/10.22435/jki.v0i0.4937","url":null,"abstract":"Pharmacies are an inseparable part of the drug distribution chain until it reaches the patient. However, patients often hear complaints about the availability of drugs in pharmacies because sometimes there are drug shortage. The aim of this study was to identify the drug procurement pattern in four network pharmacies in the Bumi Serpong Damai (BSD) area in 2019. A retrospective study of four network pharmacies in the Bumi Serpong Peace (BSD) area of South Tangerang was carried out. A total of 8,959 samples were obtained by census from procurement documents of all drugs sold beginning in 2019. (A, B, C, and D pharmacies). The ABC and VEN methods were used in this study. The information gathered includes the name of the drug, the unit, the manufacturer's name, the creditor's name, and the amount and selling price. During 2019, four pharmacies had a total of 2,876 medicinal items of pharmacy A, 1,918 medicinal items of pharmacy B, 1,939 medicinal items of pharmacy C, and 2,226 medicinal items of pharmacy D, with a total drug expenditure of pharmacy A Rp.2,649,438;pharmacy B Rp.683,389,661; pharmacy C Rp. 881,540,329; and pharmacy D Rp. 1,245,520,143. Based on the findings of the study, it is possible to conclude that the four pharmacies have the most drugs in the essential category based on the VEN analysis. However, based on the Pareto ABC analysis, there are still many drugs in four network pharmacies in the BSD Region that fall into the Pareto C category, necessitating further investigation of the procurement.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43298574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ethanol extract of guava leaf (Psidium guajava L.) contains flavonoids and tannins that are potentially as an antioxidant that may inhibit the activity of free radicals.The aim of this study is to formulate a body scrub cream from ethanol extract of guava leaf (Psidium guajava L.) and test their antioxidant activity.This study used three variations of concentration of ethanol extract 70% of guava leaf (Psidium guajava L.) i.e 1,5%, 2% and 2,5%.Body scrub creams are formulated into O/W type of creams by using guava seeds as a scrub.Evaluation of preparations included organoleptic examination, homogeneity, pH, cream type, stability test, particle size distribution, dispersion test and antioxidant activity test using DPPH method. The evaluation results showed that the physical properties of cream preparations provided good results and meet the requirements of cream preparations.The results of the antioxidant activity test found that the values of IC50 for each formula was F0 (without extract) 379,58 µg / mL, F1 (1,5%) 150,78 µg/mL, F2 (2%) 137,26 µg/mL and F3 (2,5%) 125,84 µg/mL.It can be concluded that body scrub creams of ethanol extract 70% of guava leaves (Psidium guajava L.) has the potential to be developed as a cosmetic preparation that can inhibit free radicals.
{"title":"Formulasi dan Uji Aktivitas Antioksidan Krim Biji dan Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.) sebagai Body Scrub","authors":"Noni Rahayu Putri, Diana Agustin, Khairatun Nisa","doi":"10.22435/jki.v0i0.4673","DOIUrl":"https://doi.org/10.22435/jki.v0i0.4673","url":null,"abstract":"Ethanol extract of guava leaf (Psidium guajava L.) contains flavonoids and tannins that are potentially as an antioxidant that may inhibit the activity of free radicals.The aim of this study is to formulate a body scrub cream from ethanol extract of guava leaf (Psidium guajava L.) and test their antioxidant activity.This study used three variations of concentration of ethanol extract 70% of guava leaf (Psidium guajava L.) i.e 1,5%, 2% and 2,5%.Body scrub creams are formulated into O/W type of creams by using guava seeds as a scrub.Evaluation of preparations included organoleptic examination, homogeneity, pH, cream type, stability test, particle size distribution, dispersion test and antioxidant activity test using DPPH method. The evaluation results showed that the physical properties of cream preparations provided good results and meet the requirements of cream preparations.The results of the antioxidant activity test found that the values of IC50 for each formula was F0 (without extract) 379,58 µg / mL, F1 (1,5%) 150,78 µg/mL, F2 (2%) 137,26 µg/mL and F3 (2,5%) 125,84 µg/mL.It can be concluded that body scrub creams of ethanol extract 70% of guava leaves (Psidium guajava L.) has the potential to be developed as a cosmetic preparation that can inhibit free radicals.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46702026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Galuh Ratnawati, K. Damayanti, Agung Endro Nugroho
Asthma is still become a major health problem worldwide, affected all ages from pediatrics to adults. The severity of the disease vary from mild to severe and leads to the risk of death. The uses of medicinal plants as antiasthmatic have often been conducted by the local community. The present study was conducted in vitro and in vivo to determine the activities of herbs containing of sembung leaves (Blumea balsamifera L.), kemukus seeds (Piper cubeba L.), teki rhizome (Cyperus rotundus L.), and patikan kebo herbs (Euphorbia hirta L.) with certain ratio as an antiasthmatic. The in vitro test was carried out on isolated smooth muscle cells of guinea pig. Histamine was used to stimulate the contraction of smooth muscle cells of guinea pig trachea. The in vivo test was carried out using guinea pigs which sensitized with ovalbumin and administered with the herbs formula. The trachea of guinea pigs were prepared for histopathological examination and stained on toluidine blue. The result revealed that the antiasthmatic herbs of 1, 2, and 3 showed activities as H1 receptor antagonists. The antiasthmatic herbs of 1, 2, and 3 were able to relax the smooth muscle of guinea pig’s trachea that was experiencing contraction, but in lower level compared to theophylline. The antiasthmatic herbs formula in this study did not have the activity to inhibit mast cell degranulation.
{"title":"Aktivitas Ramuan Herbal sebagai Antagonis Reseptor H1, Relaksan Otot Polos dan Penghambat Degranulasi Sel Mast sebagai Antiasmatik","authors":"Galuh Ratnawati, K. Damayanti, Agung Endro Nugroho","doi":"10.22435/jki.v0i0.4676","DOIUrl":"https://doi.org/10.22435/jki.v0i0.4676","url":null,"abstract":"Asthma is still become a major health problem worldwide, affected all ages from pediatrics to \u0000adults. The severity of the disease vary from mild to severe and leads to the risk of death. The \u0000uses of medicinal plants as antiasthmatic have often been conducted by the local community. \u0000The present study was conducted in vitro and in vivo to determine the activities of herbs \u0000containing of sembung leaves (Blumea balsamifera L.), kemukus seeds (Piper cubeba L.), teki \u0000rhizome (Cyperus rotundus L.), and patikan kebo herbs (Euphorbia hirta L.) with certain ratio \u0000as an antiasthmatic. The in vitro test was carried out on isolated smooth muscle cells of guinea \u0000pig. Histamine was used to stimulate the contraction of smooth muscle cells of guinea pig \u0000trachea. The in vivo test was carried out using guinea pigs which sensitized with ovalbumin \u0000and administered with the herbs formula. The trachea of guinea pigs were prepared for \u0000histopathological examination and stained on toluidine blue. The result revealed that the \u0000antiasthmatic herbs of 1, 2, and 3 showed activities as H1 receptor antagonists. The \u0000antiasthmatic herbs of 1, 2, and 3 were able to relax the smooth muscle of guinea pig’s trachea \u0000that was experiencing contraction, but in lower level compared to theophylline. The \u0000antiasthmatic herbs formula in this study did not have the activity to inhibit mast cell \u0000degranulation.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48213990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Lestari, Sri Setiyowati, Triningsih Triningsih, Khoirunnisa Fauziah Asyikin, S. Suharmadi, Mujamilah Mujamilah, Grace Tjungirai Sulungbudi, S. Juliyanto
The prevalence of cancer in Indonesia is increasing and various cancer treatments still have shortcomings, cancer recurrence still occurs. Lymphoscintigraphy is a method for detecting disorders of the lymphatic system, which are closely related to cancer cells. Human serum albumin nanocolloid as a lymphoscintigraphic agent consists of particles measuring
{"title":"Optimasi Sintesa Nanokoloid Human Serum Albumin sebagai Agen Limfoskintigrafi Menggunakan Central Composite Design-Response Surface Methodology","authors":"W. Lestari, Sri Setiyowati, Triningsih Triningsih, Khoirunnisa Fauziah Asyikin, S. Suharmadi, Mujamilah Mujamilah, Grace Tjungirai Sulungbudi, S. Juliyanto","doi":"10.22435/jki.v11i1.5071","DOIUrl":"https://doi.org/10.22435/jki.v11i1.5071","url":null,"abstract":"The prevalence of cancer in Indonesia is increasing and various cancer treatments still have shortcomings, cancer recurrence still occurs. Lymphoscintigraphy is a method for detecting disorders of the lymphatic system, which are closely related to cancer cells. Human serum albumin nanocolloid as a lymphoscintigraphic agent consists of particles measuring","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44398376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Handayani, Ida Diana Sari, Nita Prihartini, Yuyun Yuniar, Retno Gitawati
Acute respiratory infection (ARI) is a common disease in the community. Riskesdas 2018 stated that ARI prevalence was 4.4% and the highest was in 1-4 years old children (8%). The capitation payment system in clinics collaborated with BPJS Kesehatan demands the physician to prescribe as effective and as efficient as possible. On the other hand, the capitation tariff obtained by clinics is considered as too low, thus constrains of the prescription leading to irrational prescribing is likely to occur. This study analyses further the prescribing pattern for ARI children in clinics and its rationality based on the difference in source of funding. A cross sectional research using retrospective method was conducted. Data were gathered from 409 medical records and or patients’ prescription of children between 1-12 years old and diagnosed as having non pneumonia ARI during 1st January to 30th November 2019. Result showed that non pneumonia ARI patients were mostly boys (54,3%) aged 1-5 years old (6.0%). The average number of items for BPJS patients was 3,45, the percentage of generic prescribing was twofold higher for BPJS group (63.94%), the percentage of essential medicine prescribing was 63.96% while the percentage of antibiotic use was lower (48.50%). Dosage propriety for BPJS patients was 70.80% which was slightly higher than non-BPJS group. Overall, the prescribing indicators and dosage properness for BPJS patients were better than non-BPJS patients.
{"title":"Pola Peresepan Anak dengan Infeksi Saluran Pernapasan Akut (ISPA) Non Pneumonia di Klinik","authors":"R. Handayani, Ida Diana Sari, Nita Prihartini, Yuyun Yuniar, Retno Gitawati","doi":"10.22435/jki.v11i2.4734","DOIUrl":"https://doi.org/10.22435/jki.v11i2.4734","url":null,"abstract":"Acute respiratory infection (ARI) is a common disease in the community. Riskesdas 2018 stated that ARI prevalence was 4.4% and the highest was in 1-4 years old children (8%). The capitation payment system in clinics collaborated with BPJS Kesehatan demands the physician to prescribe as effective and as efficient as possible. On the other hand, the capitation tariff obtained by clinics is considered as too low, thus constrains of the prescription leading to irrational prescribing is likely to occur. This study analyses further the prescribing pattern for ARI children in clinics and its rationality based on the difference in source of funding. A cross sectional research using retrospective method was conducted. Data were gathered from 409 medical records and or patients’ prescription of children between 1-12 years old and diagnosed as having non pneumonia ARI during 1st January to 30th November 2019. Result showed that non pneumonia ARI patients were mostly boys (54,3%) aged 1-5 years old (6.0%). The average number of items for BPJS patients was 3,45, the percentage of generic prescribing was twofold higher for BPJS group (63.94%), the percentage of essential medicine prescribing was 63.96% while the percentage of antibiotic use was lower (48.50%). Dosage propriety for BPJS patients was 70.80% which was slightly higher than non-BPJS group. Overall, the prescribing indicators and dosage properness for BPJS patients were better than non-BPJS patients.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41464582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The distribution of pharmacies in Indonesia is still becoming a problem. Pharmacies are mostly available around healthcare facilities such as hospitals, service providers, trade centers, transportation facilities, and main roads. The study aims to describe the distribution profile of pharmacies based on Geographic Information System (GIS) analysis and to study the relation between pharmacy distribution profiles with the number of consumer visits and prescriptions. The study is conducted in 27 sub-districts in Banyumas Regency, Central Java using Arc Gis 3.10.2 Software. Pharmacy profile, the number of consumer visits, and prescriptions at the pharmacy are obtained by distributing research questionnaires to pharmacists. The results showed that the distribution of pharmacies in the Banyumas Regency was still dominant in urban areas, which reached 55%. The average distance of pharmacies was 2.34 km. The research results on the distribution pattern of pharmacies in 27 sub-districts showed that in 3 districts (11.1%) were grouped in certain areas, in 24 other districts (88.9%), the pharmacies' distribution had a spread distribution pattern. The conclusion of the research that the distribution of pharmacies in the Banyumas Regency based on GIS visualization was still dominant in urban areas and especially in sub-districts around the capital of Banyumas Regency, Purwokerto. Based on the study, there was a relation between the average distance of pharmacies and the number of healthcare facilities on consumer visits. There was a relation between pharmacy density, population density, and the number of healthcare facilities with the number of prescriptions.
{"title":"Profil Distribusi Apotek di Kabupaten Banyumas berdasarkan Sistem Informasi Geografi dan Korelasinya dengan Jumlah Kunjungan dan Resep Tahun 2019","authors":"Abdul Manan, P. Utami, A. Siswanto","doi":"10.22435/jki.v11i2.3961","DOIUrl":"https://doi.org/10.22435/jki.v11i2.3961","url":null,"abstract":"The distribution of pharmacies in Indonesia is still becoming a problem. Pharmacies are \u0000mostly available around healthcare facilities such as hospitals, service providers, trade \u0000centers, transportation facilities, and main roads. The study aims to describe the distribution \u0000profile of pharmacies based on Geographic Information System (GIS) analysis and to study the \u0000relation between pharmacy distribution profiles with the number of consumer visits and \u0000prescriptions. The study is conducted in 27 sub-districts in Banyumas Regency, Central Java \u0000using Arc Gis 3.10.2 Software. Pharmacy profile, the number of consumer visits, and \u0000prescriptions at the pharmacy are obtained by distributing research questionnaires to \u0000pharmacists. The results showed that the distribution of pharmacies in the Banyumas Regency \u0000was still dominant in urban areas, which reached 55%. The average distance of pharmacies \u0000was 2.34 km. The research results on the distribution pattern of pharmacies in 27 sub-districts \u0000showed that in 3 districts (11.1%) were grouped in certain areas, in 24 other districts (88.9%), \u0000the pharmacies' distribution had a spread distribution pattern. The conclusion of the research \u0000that the distribution of pharmacies in the Banyumas Regency based on GIS visualization was \u0000still dominant in urban areas and especially in sub-districts around the capital of Banyumas \u0000Regency, Purwokerto. Based on the study, there was a relation between the average distance of \u0000pharmacies and the number of healthcare facilities on consumer visits. There was a relation \u0000between pharmacy density, population density, and the number of healthcare facilities with the \u0000number of prescriptions.","PeriodicalId":31842,"journal":{"name":"Jurnal Kefarmasian Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48632300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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