Pub Date : 2022-06-02DOI: 10.17650/2782-3202-2022-2-2-63-67
М. О. Rusanov, L. Kogoniya, V. Shikina
Adverse events affecting the cardiovascular system are one of the most serious problems in the general management of patients with oncological diseases, since they can jeopardize the success in the treatment of malignant neoplasms. Despite modern methods of treatment, some chemotherapeutic drugs, such as anthracyclines, HER2 /ErbB2 inhibitors can have a pronounced effect on the cardiovascular system. These toxic effects lead to cardiac arrhythmia, heart failure, vascular toxicity and even death. It is important for oncologists and cardiologists to understand the basic diagnostic and treatment strategies that should be used in the event of toxicity of this kind.
{"title":"Cardiotoxicity of anthracyclines and targeted anti-HER2/neu therapy in treatment of oncological patients","authors":"М. О. Rusanov, L. Kogoniya, V. Shikina","doi":"10.17650/2782-3202-2022-2-2-63-67","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-2-63-67","url":null,"abstract":"Adverse events affecting the cardiovascular system are one of the most serious problems in the general management of patients with oncological diseases, since they can jeopardize the success in the treatment of malignant neoplasms. Despite modern methods of treatment, some chemotherapeutic drugs, such as anthracyclines, HER2 /ErbB2 inhibitors can have a pronounced effect on the cardiovascular system. These toxic effects lead to cardiac arrhythmia, heart failure, vascular toxicity and even death. It is important for oncologists and cardiologists to understand the basic diagnostic and treatment strategies that should be used in the event of toxicity of this kind.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121413151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.17650/2782-3202-2022-2-2-38-44
T. Valiev, A. Odzharova
The incidence of Hodgkin lymphoma (HL) relapses is 8-30 % and depend on disease stage, presence of unfavorable prognostic factors and treatment programme. Modern second-line treatment programmes are based on gemcitabine and carboplatin with following autologous stem cell transplantation and can reach many-year overall survival in 70 % of patients. For increasing treatment efficacy of relapsed HL monoclonal antibodies (brentuximab vedotin) and checkpoint inhibitors (nivolumab) are supplemented. Nowadays it makes an assessment of immunochemotherapy efficacy in patients with relapsed HL, determines long-term effects of treatment. Nevertheless, preliminary results allow to find a significant therapeutic advantages of immunochemotherapy with following autologous stem cell transplantation above standard polychemotherapy.
{"title":"Nivolumab in treatment of relapsed Hodgkin lymphoma","authors":"T. Valiev, A. Odzharova","doi":"10.17650/2782-3202-2022-2-2-38-44","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-2-38-44","url":null,"abstract":"The incidence of Hodgkin lymphoma (HL) relapses is 8-30 % and depend on disease stage, presence of unfavorable prognostic factors and treatment programme. Modern second-line treatment programmes are based on gemcitabine and carboplatin with following autologous stem cell transplantation and can reach many-year overall survival in 70 % of patients. For increasing treatment efficacy of relapsed HL monoclonal antibodies (brentuximab vedotin) and checkpoint inhibitors (nivolumab) are supplemented. Nowadays it makes an assessment of immunochemotherapy efficacy in patients with relapsed HL, determines long-term effects of treatment. Nevertheless, preliminary results allow to find a significant therapeutic advantages of immunochemotherapy with following autologous stem cell transplantation above standard polychemotherapy.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"196 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124925504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.17650/2782-3202-2022-2-2-24-28
M. Chekalova, L. N. Aminova, I. A. Karev, A. Kozub
The article presents a case of diagnosis and surgical treatment of a serous borderline ovarian tumor in a patient in the first trimester of pregnancy. Instrumental diagnosis of ovarian tumors during pregnancy includes ultrasound examination throughout pregnancy and magnetic resonance imaging in the second and third trimesters. Dynamic ultrasound of the uterus and its appendages showed a tumor of the right ovary, its growth and structural changes were observed leading to suspicions of malignancy. An operation was performed: laparoscopic adnexectomy on the right with express histological examination, lavage of the abdominal cavity, resection of the greater omentum, biopsy of the abdominal membrane. Histological examination confirmed serous borderline ovarian tumor. Subsequent medical care was aimed towards pregnancy prolongation. The described case of serous borderline tumor corresponded to stage I of the disease which allows to hope for a favorable prognosis for the performed surgical treatment.
{"title":"Serous borderline ovarian tumor and pregnancy. Clinical case","authors":"M. Chekalova, L. N. Aminova, I. A. Karev, A. Kozub","doi":"10.17650/2782-3202-2022-2-2-24-28","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-2-24-28","url":null,"abstract":"The article presents a case of diagnosis and surgical treatment of a serous borderline ovarian tumor in a patient in the first trimester of pregnancy. Instrumental diagnosis of ovarian tumors during pregnancy includes ultrasound examination throughout pregnancy and magnetic resonance imaging in the second and third trimesters. Dynamic ultrasound of the uterus and its appendages showed a tumor of the right ovary, its growth and structural changes were observed leading to suspicions of malignancy. An operation was performed: laparoscopic adnexectomy on the right with express histological examination, lavage of the abdominal cavity, resection of the greater omentum, biopsy of the abdominal membrane. Histological examination confirmed serous borderline ovarian tumor. Subsequent medical care was aimed towards pregnancy prolongation. The described case of serous borderline tumor corresponded to stage I of the disease which allows to hope for a favorable prognosis for the performed surgical treatment.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124438619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.17650/2782-3202-2022-2-2-45-50
I. N. Iurichev, V. Vereshchak, A. Mudunov, A. A. Marienko
Dysphagia and formation of scarring stenoses after laryngectomy are common complications in oncological practice. One of the treatment methods for the strictures is endoscopic balloon dilation which is characterized by relatively high effectiveness. However, in patients who underwent both laryngectomy and chemoradiation treatment (before or after surgery), the risk of recurring scarring strictures is significantly higher. The article describes a case of successful treatment of a patient with dysphagia after integrative treatment of laryngeal cancer consisting of chemoradiotherapy and laryngectomy. After multiple procedures of balloon dilation, endoscopic stenting of the scar narrowing was performed.
{"title":"Endoscopic techniques used in scarring stenoses after laryngectomy. Clinical observation","authors":"I. N. Iurichev, V. Vereshchak, A. Mudunov, A. A. Marienko","doi":"10.17650/2782-3202-2022-2-2-45-50","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-2-45-50","url":null,"abstract":"Dysphagia and formation of scarring stenoses after laryngectomy are common complications in oncological practice. One of the treatment methods for the strictures is endoscopic balloon dilation which is characterized by relatively high effectiveness. However, in patients who underwent both laryngectomy and chemoradiation treatment (before or after surgery), the risk of recurring scarring strictures is significantly higher. The article describes a case of successful treatment of a patient with dysphagia after integrative treatment of laryngeal cancer consisting of chemoradiotherapy and laryngectomy. After multiple procedures of balloon dilation, endoscopic stenting of the scar narrowing was performed.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133473601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.17650/2782-3202-2022-2-2-14-23
Yu. E. Ryabukhina, A. Fedenko, P. A. Zeynalova, O. L. Timofeeva, F. М. Abbasbeyli, D. Chekini, A. Mudunov, A. Batsev, O. V. Sinitsyna, A. G. Zhukov, L. A. Shestakova, G. Allakhverdieva, I. Yurichev
Alveolar rhabdomyosarcoma (ARMS) is an aggressive primitive tumor with limited differentiation of rhabdomyoblasts. Primarily, it occurs in children and teens under 15 years of age in the head and neck region (in 40 % of cases). In patients older than 19-20 years, ARMS is significantly less common and is localized primarily on the limbs, while head and neck region is affected in about 24 % of all cases, involvement of the orbit in the tumor process is very rare. ARMS progression in adults is more aggressive than in children, and prognosis is more unfavorable due to development of regional and distant metastases at the time of diagnosis. Hence, selection of antitumor therapy is limited to drug treatment. Use of multimodal approach to therapy allows to improve treatment outcomes and increase quality of life in patients with ARMS.
{"title":"Clinical and morphological observation of a 19-year-old patient with alveolar rhabdomyosarcoma of the head and neck region","authors":"Yu. E. Ryabukhina, A. Fedenko, P. A. Zeynalova, O. L. Timofeeva, F. М. Abbasbeyli, D. Chekini, A. Mudunov, A. Batsev, O. V. Sinitsyna, A. G. Zhukov, L. A. Shestakova, G. Allakhverdieva, I. Yurichev","doi":"10.17650/2782-3202-2022-2-2-14-23","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-2-14-23","url":null,"abstract":"Alveolar rhabdomyosarcoma (ARMS) is an aggressive primitive tumor with limited differentiation of rhabdomyoblasts. Primarily, it occurs in children and teens under 15 years of age in the head and neck region (in 40 % of cases). In patients older than 19-20 years, ARMS is significantly less common and is localized primarily on the limbs, while head and neck region is affected in about 24 % of all cases, involvement of the orbit in the tumor process is very rare. ARMS progression in adults is more aggressive than in children, and prognosis is more unfavorable due to development of regional and distant metastases at the time of diagnosis. Hence, selection of antitumor therapy is limited to drug treatment. Use of multimodal approach to therapy allows to improve treatment outcomes and increase quality of life in patients with ARMS.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134056866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.17650/2782-3202-2022-2-2-29-37
J. Madyarov, A. Rasulov, A. E. Kulikov, Z. Rasulov, M. Fedyanin, A. Polynovskiy
Objective: To assess the impact of mesorectal excision for upper rectal cancer on long-term treatment results.Materials and methods. 227 patients with upper rectal cancer in the period between January 2004 and December 2014 were analyzed. The study included patients over 18 years of age with upper rectal cancer, stage T2-4N0-2M0. The patients were divided into 2 groups: partial mesorectal excision (PME) and total mesorectal excision (TME).Results. 226 (99.6 %) of 227 patients underwent surgical treatment. PME was performed in 199 (85.4 %) patients, TME in 27 (14.6 %) patients. TME was significantly more often performed in patients with preoperative treatment (р = 0.03). Operative time did not differ significantly between the two groups (TME - 186 minutes and PME - 168 minutes; р = 0.34). Postoperative complications were observed in 12.3 % of cases with no significant differences between the groups (TME - 14.3 %, PME - 12.1 %; р = 0.68). Anastomotic failure was noted in 7.1 % of cases, all in the PME group. Median follow-up was 57 months. The number of deaths was 29 (12.8 %), in the PME group - 27 (13.6 %), and in the TME group - 2 (7.4 %) (р = 0.61). Local recurrences developed in 4 (2.2 %) patients of the PME group and none in TME group. Distant metastases were diagnosed in 2 patients (8 %) of the TME group and 23 patients (12.1 %) of the PME group (р = 0.509). Overall 5-year survival in the TME group was 79.6 %, in the PME group - 86.3 % (р = 0.463), and 5-year disease-free survival was 79.3 % and 86 %, respectively (р = 0.521).Conclusion. Multivariate analysis showed that the volume of mesorectal excision did not affect the rate of disease recurrence and disease-free survival in both groups.
{"title":"Is total mesorectal excision necessary for treatment of upper rectal cancer?","authors":"J. Madyarov, A. Rasulov, A. E. Kulikov, Z. Rasulov, M. Fedyanin, A. Polynovskiy","doi":"10.17650/2782-3202-2022-2-2-29-37","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-2-29-37","url":null,"abstract":"Objective: To assess the impact of mesorectal excision for upper rectal cancer on long-term treatment results.Materials and methods. 227 patients with upper rectal cancer in the period between January 2004 and December 2014 were analyzed. The study included patients over 18 years of age with upper rectal cancer, stage T2-4N0-2M0. The patients were divided into 2 groups: partial mesorectal excision (PME) and total mesorectal excision (TME).Results. 226 (99.6 %) of 227 patients underwent surgical treatment. PME was performed in 199 (85.4 %) patients, TME in 27 (14.6 %) patients. TME was significantly more often performed in patients with preoperative treatment (р = 0.03). Operative time did not differ significantly between the two groups (TME - 186 minutes and PME - 168 minutes; р = 0.34). Postoperative complications were observed in 12.3 % of cases with no significant differences between the groups (TME - 14.3 %, PME - 12.1 %; р = 0.68). Anastomotic failure was noted in 7.1 % of cases, all in the PME group. Median follow-up was 57 months. The number of deaths was 29 (12.8 %), in the PME group - 27 (13.6 %), and in the TME group - 2 (7.4 %) (р = 0.61). Local recurrences developed in 4 (2.2 %) patients of the PME group and none in TME group. Distant metastases were diagnosed in 2 patients (8 %) of the TME group and 23 patients (12.1 %) of the PME group (р = 0.509). Overall 5-year survival in the TME group was 79.6 %, in the PME group - 86.3 % (р = 0.463), and 5-year disease-free survival was 79.3 % and 86 %, respectively (р = 0.521).Conclusion. Multivariate analysis showed that the volume of mesorectal excision did not affect the rate of disease recurrence and disease-free survival in both groups.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133044066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.17650/2782-3202-2022-2-2-51-62
Yu. E. Ryabukhina, P. A. Zeynalova, V. E. Gruzdev, M. A. Anisimov, A. Fedenko, O. L. Timofeeva, F. М. Abbasbeyli, D. A. Chekin, A. G. Zhukov
Recently due to significant successes in drug therapy of malignant tumors, the question of quality of life of patients has become more important. Cyclical drug treatment implies intravenous infusion of antitumor agents. Complications associated with this type of therapy include phlebitis and extravasation and, in some cases, lead to full obliteration of vessel lumen and vast skin and hypoderm necrosis. Multiple venous punctions can with time lead to significant technical difficulties in accessing the vein and limit the continuation of therapy. This drives the necessity to search for rational approaches to patient safety during both outpatient and inpatient antitumor drug treatment. To solve this problem, fully implanted venous port systems were developed and implemented in clinical practice which provide organization of aseptic continuous venous access, as well as infusion pumps (for independent prolonged intravenous therapy). Use of these devices allows for continuity and cycling of treatment process, significantly improves patients' quality of life by not limiting daily activities.In the article we present our experience of using microinfusion single-use mechanical systems for antitumor drug therapy and relief of intense pain syndrome in patients with malignant disorders of hematopoietic tissue and solid tumors.
{"title":"Safe drug therapy in clinical practice: experience of using microinfusion single-use mechanical systems in treatment of patients with malignant diseases of hematopoietic tissue and solid tumors","authors":"Yu. E. Ryabukhina, P. A. Zeynalova, V. E. Gruzdev, M. A. Anisimov, A. Fedenko, O. L. Timofeeva, F. М. Abbasbeyli, D. A. Chekin, A. G. Zhukov","doi":"10.17650/2782-3202-2022-2-2-51-62","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-2-51-62","url":null,"abstract":"Recently due to significant successes in drug therapy of malignant tumors, the question of quality of life of patients has become more important. Cyclical drug treatment implies intravenous infusion of antitumor agents. Complications associated with this type of therapy include phlebitis and extravasation and, in some cases, lead to full obliteration of vessel lumen and vast skin and hypoderm necrosis. Multiple venous punctions can with time lead to significant technical difficulties in accessing the vein and limit the continuation of therapy. This drives the necessity to search for rational approaches to patient safety during both outpatient and inpatient antitumor drug treatment. To solve this problem, fully implanted venous port systems were developed and implemented in clinical practice which provide organization of aseptic continuous venous access, as well as infusion pumps (for independent prolonged intravenous therapy). Use of these devices allows for continuity and cycling of treatment process, significantly improves patients' quality of life by not limiting daily activities.In the article we present our experience of using microinfusion single-use mechanical systems for antitumor drug therapy and relief of intense pain syndrome in patients with malignant disorders of hematopoietic tissue and solid tumors.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116990496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-04DOI: 10.17650/2782-3202-2022-2-1-28-32
M. Davydov, P. A. Zeynalovа, A. Fedenko, E. K. Ibragimov, D. A. Chekiny, A. A. Filimonov, E. V. Dementievа
Neuroendocrine tumors are rare type of tumors of the gastrointestinal tract. Mostly the patient is diagnosed rather late, the tumors don’t have specific symptoms and there are no sensitive and specific methods of early diagnostics of the disease. Also, to date, the choice of antitumor treatment methods is limited. The article presents a clinical case of effective treatment of a neuroendocrine tumor of the colon with high level of microsatellite instability. After palliative partial colectomy, atypical resection of the liver, female patient with metastatic cancer of the descending colon has been receiving therapy with checkpoint inhibitors (PD-1) which led to long-term stabilization of the process.
{"title":"Effective application of integrative approach in treatment of neuroendocrine colon cancer. Clinical case","authors":"M. Davydov, P. A. Zeynalovа, A. Fedenko, E. K. Ibragimov, D. A. Chekiny, A. A. Filimonov, E. V. Dementievа","doi":"10.17650/2782-3202-2022-2-1-28-32","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-1-28-32","url":null,"abstract":"Neuroendocrine tumors are rare type of tumors of the gastrointestinal tract. Mostly the patient is diagnosed rather late, the tumors don’t have specific symptoms and there are no sensitive and specific methods of early diagnostics of the disease. Also, to date, the choice of antitumor treatment methods is limited. The article presents a clinical case of effective treatment of a neuroendocrine tumor of the colon with high level of microsatellite instability. After palliative partial colectomy, atypical resection of the liver, female patient with metastatic cancer of the descending colon has been receiving therapy with checkpoint inhibitors (PD-1) which led to long-term stabilization of the process.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132039184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-04DOI: 10.17650/2782-3202-2022-2-1-39-47
A. Rasulov, Z. Rasulov, J. Madyarov, A. E. Kulikov, Y. Stoyko, A. Maksimenkov, A. Botov, Sh. A. Alishikhov, Yu. E. Lʼvova, A. Otabekov
The study objective was to evaluate the impact of medical hospital volume on short-term colorectal cancer treatment results.Materials and methods. The retrospective study included 93 patients with colorectal cancer operated on by one surgeon at two medical centers in Moscow from 2018 to 2020: 32 patients of the first group were operated in tertiary medical center (N.I. Pirogov National Medical and Surgical Center) and 61 of the second group – in regional low volume hospital (Centrosoyuz Hospital). The endpoints of the study were the short-term outcomes: surgery duration, blood loss, postoperative hospital stay, intra- and postoperative complications, lymph node harvested and the quality of specimen.Results. Surgery duration as well as blood loss in two groups were similar (258 min vs 240 min, p = 0.47 and 100 ml and 100 ml, p = 0.89, accordingly). Hospital stay after surgery was significantly less in the first group (9 days vs 16 days, p <0.01). The frequency of postoperative complications of type I–II according to the Clavien–Dindo classification was higher in the first group (6/8 vs 1/8, p <0.05) but reoperations performed more in the second group due to III Clavien–Dindo complications (2/8 vs 7/8, p = 0.012). Grade 2–3 rectal cancer specimen quality was 94.7 % vs 77.8 %, p = 0.13 and harvested lymph nodes >12 was 71.9 % vs 78.7 %, p = 0.485 in first and second group, respectively.Conclusion. Hospital volume does not affect rectal cancer specimen quality, surgery duration and blood loss, if the surgical interventions are performed by one experienced surgeon but associated with the incidence of postoperative complications and the length of stay.
本研究的目的是评价医院容积对结直肠癌短期治疗效果的影响。材料和方法。回顾性研究包括2018年至2020年在莫斯科两家医疗中心由一名外科医生手术的93例结直肠癌患者:第一组32例患者在三级医疗中心(N.I. Pirogov国家医疗和外科中心)手术，第二组61例患者在地区小容量医院(Centrosoyuz医院)手术。研究的终点是短期结果:手术时间、出血量、术后住院时间、手术内和术后并发症、淋巴结收获和标本质量。两组手术时间和出血量相似(258 min vs 240 min, p = 0.47, 100 ml和100 ml, p = 0.89)。第一组患者术后住院时间明显缩短(9天vs 16天，p12分别为71.9% vs 78.7%， p = 0.485)。如果由一位经验丰富的外科医生进行手术干预，但与术后并发症的发生率和住院时间有关，则医院容量不会影响直肠癌标本质量、手术时间和出血量。
{"title":"Does the level of medical facility impact short-term results of surgical treatment of colorectal cancer","authors":"A. Rasulov, Z. Rasulov, J. Madyarov, A. E. Kulikov, Y. Stoyko, A. Maksimenkov, A. Botov, Sh. A. Alishikhov, Yu. E. Lʼvova, A. Otabekov","doi":"10.17650/2782-3202-2022-2-1-39-47","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-1-39-47","url":null,"abstract":"The study objective was to evaluate the impact of medical hospital volume on short-term colorectal cancer treatment results.Materials and methods. The retrospective study included 93 patients with colorectal cancer operated on by one surgeon at two medical centers in Moscow from 2018 to 2020: 32 patients of the first group were operated in tertiary medical center (N.I. Pirogov National Medical and Surgical Center) and 61 of the second group – in regional low volume hospital (Centrosoyuz Hospital). The endpoints of the study were the short-term outcomes: surgery duration, blood loss, postoperative hospital stay, intra- and postoperative complications, lymph node harvested and the quality of specimen.Results. Surgery duration as well as blood loss in two groups were similar (258 min vs 240 min, p = 0.47 and 100 ml and 100 ml, p = 0.89, accordingly). Hospital stay after surgery was significantly less in the first group (9 days vs 16 days, p <0.01). The frequency of postoperative complications of type I–II according to the Clavien–Dindo classification was higher in the first group (6/8 vs 1/8, p <0.05) but reoperations performed more in the second group due to III Clavien–Dindo complications (2/8 vs 7/8, p = 0.012). Grade 2–3 rectal cancer specimen quality was 94.7 % vs 77.8 %, p = 0.13 and harvested lymph nodes >12 was 71.9 % vs 78.7 %, p = 0.485 in first and second group, respectively.Conclusion. Hospital volume does not affect rectal cancer specimen quality, surgery duration and blood loss, if the surgical interventions are performed by one experienced surgeon but associated with the incidence of postoperative complications and the length of stay.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134220749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-04DOI: 10.17650/2782-3202-2022-2-1-19-27
A. Mudunov, A. Batsev, A. Maryenko, M. Shogenov
Esophageal cancer is one of the hardest to treat malignant cancers. Patient prognosis remains unsatisfactory despite considerable progress in surgical, radiation, and drug treatments. Surgery remains the main form of treatment for this pathology as it is the only radical treatment method. The objective is to evaluate short-term treatment results for cancer of the cervical esophagus and laryngopharynx after large-scale resection with reconstruction and plastic surgery stage. A clinical case of locally advanced squamous cell carcinoma of the mucosa of the cervical esophagus is presented. Use of free radial fasciocutaneous flap for reconstruction of the cervical esophagus with preservation of the pharynx is described. Problems of diagnosis and surgical treatment of this pathology from the point of view of our clinic’s experience are considered. We show that radial forearm flap can be used for reconstruction of the pharynx and cervical esophagus during circular resections.
{"title":"Clinical observation of cervical esophageal cancer","authors":"A. Mudunov, A. Batsev, A. Maryenko, M. Shogenov","doi":"10.17650/2782-3202-2022-2-1-19-27","DOIUrl":"https://doi.org/10.17650/2782-3202-2022-2-1-19-27","url":null,"abstract":"Esophageal cancer is one of the hardest to treat malignant cancers. Patient prognosis remains unsatisfactory despite considerable progress in surgical, radiation, and drug treatments. Surgery remains the main form of treatment for this pathology as it is the only radical treatment method. The objective is to evaluate short-term treatment results for cancer of the cervical esophagus and laryngopharynx after large-scale resection with reconstruction and plastic surgery stage. A clinical case of locally advanced squamous cell carcinoma of the mucosa of the cervical esophagus is presented. Use of free radial fasciocutaneous flap for reconstruction of the cervical esophagus with preservation of the pharynx is described. Problems of diagnosis and surgical treatment of this pathology from the point of view of our clinic’s experience are considered. We show that radial forearm flap can be used for reconstruction of the pharynx and cervical esophagus during circular resections.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115052359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：