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A Case of 27-Year-Old Localized Solitary Neurofibroma of the Base Tongue; A Case Report 27岁患者基底舌局部孤立性神经纤维瘤1例病例报告
Pub Date : 2022-05-18 DOI: 10.34172/hpr.2022.16
Sohbat Rezaee, Manouchehr Avatef Fazeli, Arefeh Hedayati
Introduction: Neurofibromas, benign peripheral nerve sheath tumors, are the most common among neural lesion. Neurofibromas are rare in head and neck location, although it may involve any part of oral cavity. However, tongue is the most common region. Case Presentation: A 27 year-old man was admitted to Otorhinolaryngology Department due to a swelling in the base of his tongue, since two weeks before. This mass was painless, and without any associated symptoms. He was suffered from a mild eating disorder, too. He had no any positive past medical history, and only a large soft 6×5 cm mass was found at the base of his tongue without bleeding in the oral cavity. Excisional biopsy was performed for him under general anesthesia and the tumor was easily enucleated. The final diagnosis was neurofibroma. After the diagnosis of neurofibroma, the physical reexamination revealed a series of café au lait spots on his skin. Conclusion: the neurofibroma should be considered by otorhinolaryngologist, as a differential diagnosis of tongue mass, and more accurate physical examination are recommended for better management.
简介:神经纤维瘤是神经病变中最常见的一种良性周围神经鞘肿瘤。神经纤维瘤很少发生在头颈部,但也可能发生在口腔的任何部位。然而,舌头是最常见的区域。病例介绍:一名27岁男子,因舌底肿大,于两周前住进耳鼻喉科。肿块无痛,无任何相关症状。他还患有轻微的饮食失调症。患者既往无任何阳性病史,仅在舌底发现一个巨大的6×5厘米软肿块,口腔无出血。他在全身麻醉下进行了切除活检,肿瘤很容易去核。最终诊断为神经纤维瘤。在诊断为神经纤维瘤后,体检发现他的皮肤上有一系列的咖啡色斑点。结论:耳鼻喉科医师应将神经纤维瘤作为舌肿块的鉴别诊断,并建议进行更准确的体格检查,以便更好地治疗。
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引用次数: 1
Patterns of Hba1c Levels in Normoglycemic Offspring of T2 Diabetes Mellitus Patients t2dm患者正常血糖子代Hba1c水平的变化规律
Pub Date : 2022-04-15 DOI: 10.34172/hpr.2022.10
E. Taiwo., L. Thanni, Oyesimisola P. Taiwo
Background: The risk of developing diabetes mellitus for an individual with a positive family history of the disease is two- to fourfold higher in an offspring of a diabetic compared with offspring of non-diabetic shown by serum glycated hemoglobin (HbA1c) levels. There is paucity of data on pre-diabetes in our environment. Objectives: This study was designed to determine the baseline HbA1c levels of normoglycemic offspring of type 2 diabetes mellitus (T2DM) patients in Ijebu-ode, Nigeria. Methods: This is a cross-sectional study of offspring of T2DM patients (ODP) and those of offspring of non-diabetic parents (ONDP). Diabetic offspring were exempted from the study. FBS was determined using enzymatic hexokinase method to determine glucose concentrations and exclude diabetes. Serum HbA1c was measured using standard method. Height and weight were measured using standard methods. Body mass index (BMI) was calculated. Results: There were 100 ODP and 100 ONDP aged 16 to 40 years. The most populated aged group was 21 to25 years which is 44% (n=88). 6% (n=12) of the study group were obese. 19% were overweight (n=38). The mean weight of ODP was significantly higher than that of ONDP (P=0.020). Also, the mean HBA1c of ODP was significantly higher than that of ONDP (P<0.001). Conclusion: The serum HbA1c level was significantly higher among ODP than ONDP. The mean weight was significantly higher in ODP than ONDP.
背景:血清糖化血红蛋白(HbA1c)水平显示,糖尿病家族史阳性个体的后代患糖尿病的风险是非糖尿病后代的2 - 4倍。在我们的环境中,关于糖尿病前期的数据很少。目的:本研究旨在确定尼日利亚Ijebu-ode 2型糖尿病(T2DM)患者后代的基线HbA1c水平。方法:这是一项T2DM患者(ODP)和非糖尿病父母(ONDP)后代的横断面研究。糖尿病后代不在研究范围内。FBS采用酶促己糖激酶法测定葡萄糖浓度,排除糖尿病。采用标准方法测定血清HbA1c。身高和体重采用标准方法测量。计算身体质量指数(BMI)。结果:16 ~ 40岁ODP 100例,ONDP 100例。人口最多的年龄组是21 ~ 25岁,占44% (n=88)。研究组中6% (n=12)为肥胖。19%超重(n=38)。ODP的平均权重显著高于ONDP (P=0.020)。ODP组的平均HBA1c显著高于ONDP组(P<0.001)。结论:ODP患者血清HbA1c水平明显高于ONDP患者。ODP的平均体重明显高于ONDP。
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引用次数: 0
Pneumonia in COVID-19 Without Lower Respiratory Symptoms: A Case Report 无下呼吸道症状的新型冠状病毒肺炎1例报告
Pub Date : 2022-04-11 DOI: 10.34172/hpr.2022.15
Reyhaneh Abolghasemi, M. Saeedi
Introduction: The main symptoms of new coronavirus in patients are fever or chills, tiredness, and dry cough. In this case, we reported a woman who got involved in COVID-19 pneumonia with gastrointestinal instead of lower respiratory symptoms. Case Presentation: A 67 years old woman was referred to an outpatient clinic in Tehran with fever, chills, sneezing, tiredness, severe nausea, anorexia, and diarrhea. She did not have a cough, dyspnea, or chest pain and her lung sound was normal. According to the blood O2 saturation decreasing, C-reactive protein increasing, and the lung imaging findings, she was admitted with COVID-19 pneumonia diagnosis in the infectious care department of a hospital. The 2019-nCoV real-time polymerase chain reaction (PCR) intranasal assay was negative. She was treated with intranasal oxygen therapy, anti-inflammatory drugs, and prednisone. After one week she was discharged in generally good condition and quarantined for two weeks later. After 25 days the COVID-19 IgM and IgG antibodies were in positive ranges. Conclusion: Severe fatigue, mainly in elders caused the inability to cough, and light inspiration force especially in the lower lung lobes could explain the normal lung sounds in the physical examination. Also, we hypothesized that reverse circulation of the virus may occur from the gastro intestine to the respiratory system. The gut-lung microbial imbalance may affect the severity in patients with extrapulmonary symptoms, especially in old ages. Furthermore, damage to the vagus nerve along the path in the proximity to lungs infected with COVID-19 can cause nausea without gastrointestinal involvement.
新冠肺炎患者的主要症状为发热或发冷、疲倦、干咳。在这种情况下,我们报告了一名女性,她感染了COVID-19肺炎,出现了胃肠道症状,而不是下呼吸道症状。病例介绍:一名67岁妇女因发热、发冷、打喷嚏、疲倦、严重恶心、厌食和腹泻被转诊至德黑兰一家门诊。无咳嗽、呼吸困难、胸痛,肺音正常。根据血氧饱和度下降,c反应蛋白升高,肺部影像学表现,诊断为COVID-19肺炎入住医院感染科。新型冠状病毒鼻内实时聚合酶链反应(PCR)检测结果为阴性。她接受了鼻内氧疗、抗炎药物和强的松治疗。一周后,她出院,情况大致良好,随后被隔离了两周。25天后,COVID-19 IgM和IgG抗体均在阳性范围内。结论:以老年人为主的严重疲劳引起的不能咳嗽,轻的吸气力特别是下肺叶的吸气力可以解释体检时肺音正常。此外,我们假设病毒的反向循环可能发生从胃肠道到呼吸系统。肠-肺微生物失衡可能影响肺外症状患者的严重程度,尤其是老年人。此外,感染COVID-19的肺部附近路径的迷走神经受损可引起恶心,但不会累及胃肠道。
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引用次数: 0
The Saga of Non-COVID Patients in COVID Times: Our Experience in a Secondary Care Hospital in Hilly Terrain, Northern India COVID时代非COVID患者的传奇:我们在印度北部丘陵地区二级护理医院的经验
Pub Date : 2022-02-21 DOI: 10.34172/hpr.2022.02
S. Khanna, Saurabh Maheshwari, Sai Vishal Goud Vaggu, H. Bayad, Shruti Samyal
Background: The coronavirus disease 2019 (COVID-19) pandemic resulted in the diversion of all the resources, attention, and energy of the medical personnel and administration towards the management of COVID-19 patients. This resulted in unforeseen difficulties and hazards for non-COVID-19 patients in accessing healthcare professionals and facilities. Objectives: The objective of this study was to analyze the impact of the COVID-19 pandemic and repeated lockdowns on the non-COVID patients; to understand the social, psychological, and medical issues faced by them; and propose solutions for difficulties faced by this specific cohort of patients. Methods: We conducted a retrospective observational study on all non-COVID patients reporting for non-COVID-19 illnesses. We conducted the data analysis by comparing the trends for 15 months each in the pre-pandemic (1 January 2019 to 31 March 2020) and pandemic periods (1 April 2020 to 30 June 2021). Results: There was a 65.92% decrease in Out Patient Department (OPD) attendance, a 56.05% decrease in admissions, and a 90.33 % decrease in elective surgical procedures in non-COVID-19 patients. However, there was a significant increase in emergency surgeries by 62.16%. Conclusion: There has been a significant albeit much-needed diversion of time, energy, and resources to manage COVID-19 patients in recent times. This has led to a paucity of care opportunities for non-COVID-19 patients, which has been further compounded by the frequent lockdowns. We attempted to understand the impact of the pandemic on non-COVID-19 patients, particularly in peripheral hospitals in Hilly Terrains. We propose the solutions to tackle these issues and describe our experience with them.
背景:2019冠状病毒病(COVID-19)大流行导致医务人员和行政部门的所有资源、注意力和精力都转向了COVID-19患者的管理。这给非covid -19患者在获得医疗保健专业人员和设施方面带来了意想不到的困难和危险。目的:分析新冠肺炎大流行和多次封锁对非新冠肺炎患者的影响;了解他们面临的社会、心理和医疗问题;并针对这一特定患者群体所面临的困难提出解决方案。方法:对所有报告非covid -19疾病的非covid -19患者进行回顾性观察研究。我们通过比较大流行前(2019年1月1日至2020年3月31日)和大流行期间(2020年4月1日至2021年6月30日)各15个月的趋势进行了数据分析。结果:非covid -19患者的门诊出勤率下降了65.92%,入院率下降了56.05%,选择性手术次数下降了90.33%。然而,急诊手术数量明显增加了62.16%。结论:近年来,在COVID-19患者管理方面投入了大量时间、精力和资源,尽管这是急需的。这导致非covid -19患者缺乏护理机会,而频繁的封锁进一步加剧了这一情况。我们试图了解大流行对非covid -19患者的影响,特别是在丘陵地区的外围医院。我们提出了解决这些问题的解决方案,并描述了我们的经验。
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引用次数: 0
The Association of Atorvastatin Therapy With COVID-19 Outcomes and Mortality 阿托伐他汀治疗与COVID-19结局和死亡率的关系
Pub Date : 2022-02-15 DOI: 10.34172/hpr.2022.03
Hamid Reza Aghaei Meybodi, Seyedeh Zahra Fotook Kiaee, M. Akhavan, Samira Abbasloo, Mahnaz Pejman Sani
Background: The world is still witnessing a largely ongoing spread of coronavirus disease 2019 (COVID-19); therefore, the scientific findings in this area need to be shared promptly. Objectives: This study aimed to assess the usefulness of Atorvastatin treatment in reducing COVID-19 mortality in patients with or without diabetes mellitus (DM) and to correlate them with C-reactive protein (CRP) levels. Methods: This study consecutively enrolled patients with pneumonia symptoms, positive lung CT scan, and confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on reverse transcription-polymerase chain reaction (RT-PCR). The outcome was defined as intensive care unit (ICU) admission and death. Clinical data and history of atorvastatin administration were evaluated. CRP levels were measured at baseline and repeated after one week in all patients. Results: A total of 200 patients were included. Their mean age was 60.5 (SD=16.5) years, 113 (56.5%) patients were male, 47 (23.5%) with pre-existing diabetes, and 64 (32%) patients were taking atorvastatin routinely. 68 (34%) required ICU admission of all the studied patients. No gender differences were found in ICU admission and death. The baseline CRP was not significantly different, but the secondary CRP was significantly different between DM and non-DM groups. Secondary CRP also showed a significant reduction in patients receiving atorvastatin (P=0.017). The mortality was the same in atorvastatin or non-atorvastatin groups (P=0.715). Conclusion: It seems that taking statin has only some beneficial effects on improving CRP levels in patients with COVID-19. To achieve a reliable result, clinical trials are recommended.
背景:2019冠状病毒病(COVID-19)在世界范围内仍在持续传播;因此,这一领域的科学发现需要及时分享。目的:本研究旨在评估阿托伐他汀治疗在降低合并或不合并糖尿病(DM)患者COVID-19死亡率方面的有效性,并将其与c反应蛋白(CRP)水平联系起来。方法:本研究连续招募有肺炎症状、肺部CT扫描阳性、经逆转录聚合酶链反应(RT-PCR)确诊为严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)的患者。结果定义为重症监护病房(ICU)入住和死亡。评估阿托伐他汀的临床资料和用药史。在基线时测量CRP水平,并在一周后对所有患者重复测量。结果:共纳入200例患者。平均年龄60.5岁(SD=16.5),男性113例(56.5%),既往糖尿病47例(23.5%),常规服用阿托伐他汀64例(32%)。68例(34%)需要ICU治疗。ICU入院和死亡无性别差异。基线CRP在DM组和非DM组之间无显著性差异,但次级CRP在DM组和非DM组之间有显著性差异。在接受阿托伐他汀治疗的患者中,次级CRP也显著降低(P=0.017)。阿托伐他汀组和非阿托伐他汀组的死亡率相同(P=0.715)。结论:他汀类药物对改善COVID-19患者CRP水平似乎只有一定的有益作用。为了获得可靠的结果,建议进行临床试验。
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引用次数: 0
Assessment of Bed Utilization Indicators of Medicine Ward of a Tertiary Level Hospital: A Cross-sectional Study in Eastern India 东印度某三级医院内科病房床位利用指标评价的横断面研究
Pub Date : 2022-02-14 DOI: 10.34172/hpr.2022.04
M. Sarkar, U. Dasgupta
Background: Efficient hospital bed utilization is an important function of hospital administrators. Scarcity of beds, overcrowding, and flooring are often the picture of tertiary hospitals. Objectives: This study aims to find out hospital bed utilization indicators such as average daily census, bed occupancy rate (BOR), average length of stay (ALS), bed turnover rate (BTR), and bed turnover interval (BTI) in Medicine ward of a tertiary hospital in West Bengal, India. Methods: A descriptive cross-sectional study was conducted in acute male and female as well as chronic male and female wards under medicine department of a tertiary hospital in West Bengal from June to August 2018.The record of active beds, patient days, daily admissions and discharge were reviewed for May 2018 by complete enumeration method from admission, discharge and death registers and recorded in a pre-designed pretested checklist. Average daily census, BOR, ALS, BTR, and BTI were computed using standard formula. Pabon Lasso model was used to analyse the performance of the nedicine ward. Results: Average daily census, ALS, BOR, BTR, BTI in medicine ward were 261.81 patients, 8 days, 108.55%, 4.22 patients/ bed and -0.63 days respectively. Pabon Lasso graph reflected high BOR and high discharges per bed (productivity) in acute medicine wards reflecting good quantitative performance in contrast to chronic medicine wards with low discharges per bed (productivity or BTR) and higher ALS. Conclusion: Medicine ward reflected higher BOR and ALS but lower BTR (productivity) as per the Pabon Lasso graph. Efforts must be made to reduce ALS in chronic medicine wards.
背景:病床的高效利用是医院管理者的一项重要职能。床位短缺、过度拥挤和地板问题往往是三级医院的现状。目的:了解印度西孟加拉邦某三级医院内科病房的日均人口普查、床位入住率(BOR)、平均住院时间(ALS)、床位周转率(BTR)、床位周转期(BTI)等病床利用指标。方法:对2018年6 - 8月西孟加拉邦某三级医院内科急性病病区男女病区、慢性性病病区男女病区进行描述性横断面研究。采用完整枚举法从入院、出院和死亡登记册中审查2018年5月的有效床位、患者天数、每日入院和出院记录,并记录在预先设计的预测试清单中。采用标准公式计算日均普查、BOR、ALS、BTR和BTI。采用Pabon Lasso模型对内科病房绩效进行分析。结果:内科病房平均每日普查261.81例,ALS 8天,BOR 108.55%, BTR 4.22例/张,BTI -0.63天。Pabon Lasso图反映了急性医学病房的高BOR和高每床出院率(生产率),与低每床出院率(生产率或BTR)和较高ALS的慢性医学病房相比,反映了良好的定量表现。结论:从Pabon Lasso图可以看出,内科病房的BOR和ALS较高,但BTR(生产力)较低。必须努力减少慢性医学病房的ALS。
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引用次数: 0
Investigating Fire Protection Condition in the Units of Imam Khomeini Hospital Tehran, Iran 伊朗德黑兰伊玛目霍梅尼医院消防状况调查
Pub Date : 2022-02-14 DOI: 10.34172/hpr.2022.05
M. Fazel, A. Ardalan, A. Ostad Taghizadeh, T. Yaghoubi
Background: Various studies indicate that in many cases, fire has broken out in hospitals. Objectives: This study aims to assess fire protection in the selected units of Imam Khomeini hospital located in Tehran, Iran in 2020. Methods: In this descriptive-analytic study, first, a researcher-made checklist was developed for the data collection by valid scientific resources (CVI=0.90 and CVR>0.62). After revising and the final confirmation of reliability, the checklist was separately completed by two members of the risk management committee in 22 units of Imam Khomeini hospital, Tehran, Iran. Cronbach’s weighted Kappa statistical test was calculated. Results: The domain of Ability and Capability of Fire Prevention was 66.1%; the domain of Responsiveness was 65.1%, and the domain of Urgent Evacuation Ability was 27.3%. In the domain of Responsiveness, the highest scores were relevant to accessing fire extinguishers cylinder in the units (95.5%) and holding fire extinguishing practice courses, and doing seasonal practices with that region’s fire station (90.9% for both). The highest scores in the domain of Urgent Evacuation Ability were assigned to accessing adequate ambulances to evacuate patients (90.9%) and mapping the units as well as determining patient evacuation routes when a fire breaks out (72.7%). Conclusion: The essential protection measures should be taken in order to improve the hospitals’ fire protection by better access to the exits, increasing the number of the exits and standardizing the emergency exits, enhancing the due fire extinguishing practices and hospital evacuation as well as training the staff.
背景:各种研究表明,在许多情况下,医院发生火灾。目的:本研究旨在评估2020年伊朗德黑兰伊玛目霍梅尼医院选定单位的消防情况。方法:本研究采用描述性分析方法,首先,利用有效科学资源(CVI=0.90, CVR>0.62)编制研究者自行编制的资料收集清单;在修订和最后确认可靠性之后,清单由风险管理委员会的两名成员分别在伊朗德黑兰伊玛目霍梅尼医院的22个单位完成。计算Cronbach加权Kappa统计检验。结果:“防火能力”域占66.1%;响应性域占65.1%,紧急疏散能力域占27.3%。在响应性方面,得分最高的是在单位内使用灭火器钢瓶(95.5%)和举行灭火实践课程,以及与该地区消防站进行季节性实践(90.9%)。在紧急疏散能力领域得分最高的是获得足够的救护车疏散病人(90.9%),以及在发生火灾时绘制单位以及确定病人疏散路线(72.7%)。结论:加强出口通道、增加出口数量、规范紧急出口、加强消防规范和医院疏散、加强人员培训,是提高医院消防水平的必要防护措施。
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引用次数: 1
Assessing the Extent and Causes of Cancellation of Surgeries: An Important Issue in Improving the Efficiency of the Hospital 评估取消手术的程度和原因:提高医院效率的重要问题
Pub Date : 2022-01-20 DOI: 10.34172/hpr.2022.06
H. Jafari, Parvin Jafari, M. Rahimi, Roohollah Arab Saniabadi, Farzaneh Zare Banadkooki
Background: Canceling surgery imposes the high cost of the healthcare provider system and wasted many energy and time from the patient and the care team. Objectives: This study examined the extent and reasons of canceling of surgeries in one of the hospitals affiliated to Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Methods: This was a descriptive-applied study. In order to get the number of operations from April 2018 to March 2020, the hospital used HIS software and then extracted the reasons from the operating room office and the quality improvement office in the hospital. Data were analyzed by SPSS version 21 software. Results: Among 8654 planned surgeries, 0.9% were cancelled. The highest frequency of surgical cancellation is associated with general surgery, and the highest rate of surgical cancellation is associated with the ENT specialty. The highest cancellation rate was 1.82% in August 2018 and 2.87% in February 2019. The lack of preparation of patients and patients did not require surgery was the main and worst reason for discontinuing surgery, respectively. Conclusion: The lack of clinical preparation of the patient was the main reason for the cancellation. Therefore, pre-surgery patient evaluation can help solve this problem, make the operating room more effective, and increase patient satisfaction.
背景:取消手术增加了医疗保健提供者系统的高成本,浪费了患者和护理团队的大量精力和时间。目的:本研究调查了伊朗亚兹德Shahid Sadoughi医科大学附属医院之一取消手术的程度和原因。方法:采用描述性应用研究。为了获得2018年4月至2020年3月的手术次数,医院使用HIS软件,然后从医院手术室办公室和质量改进办公室提取原因。数据分析采用SPSS 21版软件。结果:8654例计划手术中,0.9%被取消。手术取消的最高频率与普通外科有关,最高的手术取消率与耳鼻喉专科有关。取消率最高的是2018年8月的1.82%和2019年2月的2.87%。患者准备不足和患者不需要手术分别是中断手术的主要原因和最差原因。结论:患者临床准备不足是导致手术取消的主要原因。因此,术前患者评估有助于解决这一问题,使手术室更有效率,提高患者满意度。
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引用次数: 0
Transfusion-Related Hemochromatosis Involving Pituitary Gland in a Patient of Beta-Thalassemia Major 重度β -地中海贫血1例涉及垂体的输血相关性血色素沉着症
Pub Date : 2022-01-19 DOI: 10.34172/hpr.2022.08
Brikshya Gurung, Saurabh Maheshwari, D. Grewal, Pratik Regmi, Ajay Khadka
Introduction: Hemochromatosis of the pituitary gland is a form of iron overload disease which occurs in different clinical conditions related to multiple blood transfusions. Case Presentation: We present a case of secondary hemochromatosis involving the pituitary gland and choroid plexus in an eightyear-old female with imaging findings and a review of the relevant literature. Our patient has had a history of cessation of growth in height for the last 1 year. She was diagnosed with a thalassemia major at the age of 6 months. She has been on regular blood transfusions since then. Magnetic resonance imaging (MRI) revealed evidence of iron deposition in the pituitary gland. Conclusion: This diagnosis should be suspected on clinical presentation and history of multiple blood transfusions. It can be confirmed based on characteristic imaging findings. The patient should be strictly monitored with serum iron levels, and a tailored iron chelation therapy should be initiated.
垂体血色素沉着症是一种铁超载疾病,在不同的临床条件下发生,与多次输血有关。病例介绍:我们报告一例累及脑垂体和脉络膜丛的继发性血色素沉着症,患者为一名八岁的女性,影像学表现和相关文献回顾。我们的病人在过去的一年里有身高停止增长的历史。她在6个月大的时候被诊断出患有地中海贫血。从那以后,她一直在定期输血。磁共振成像(MRI)显示脑垂体铁沉积的证据。结论:该病的诊断应结合临床表现和多次输血史加以怀疑。可根据特征性影像学表现予以确认。患者应严格监测血清铁水平,并应开始量身定制的铁螯合治疗。
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引用次数: 0
Combination Therapy of ReciGen Interferon, Methylprednisolone, and Sovodak as a Candidate for Treatment of Patients With Severe COVID-19 in Iran: A Case Series ReciGen干扰素、甲基强的松龙和索vodak联合治疗伊朗重症COVID-19患者:病例系列
Pub Date : 2022-01-19 DOI: 10.34172/hpr.2022.07
Z. Kamiab, Ali Esmaeili Nadimi, F. Bahrehmand
Introduction: During the current worldwide pandemic of coronavirus disease 2019 (CPVID-19), this disease was first identified in Iran at the end of February. This study was conducted to examine patients with severe COVID-19 disease, who were treated with three medications, namely ReciGen, methylprednisolone, and Sovodak. Case Presentation: We identified 10 patients (3 males and 7 females) with the mean (±SD) age of 55.70±21.48 years, who were admitted to the only referral hospital in Rafsanjan County (Iran) from March to July 2020 with confirmed infections with severe COVID-19. They were treated with the combination therapy of subcutaneous ReciGen interferon every other day, methylprednisolone at a dose of 250 mg every 6 hours for 5 days, and one tablet of Sovodak daily. Conclusion: In the series of cases investigated in this study, the general conditions of all patients improved in terms of their clinical parameters after receiving the combination therapy, and all patients were discharged with a blood oxygen level of≥93% and in good general conditions.
导言:在当前的2019冠状病毒病全球大流行期间,该疾病于2月底在伊朗首次被发现。本研究对重症COVID-19患者进行了检查,这些患者接受了3种药物治疗,即ReciGen、methylprednisolone和Sovodak。病例介绍:我们确定了10例患者(男3例,女7例),平均(±SD)年龄55.70±21.48岁,于2020年3月至7月在伊朗拉夫桑贾县唯一一家转诊医院确诊感染重症COVID-19。他们接受联合治疗,每隔一天皮下注射ReciGen干扰素,每6小时注射250毫克甲基强的松龙,持续5天,每天服用一片索沃达克。结论:在本研究调查的系列病例中,所有患者在接受联合治疗后,其临床参数一般情况均有所改善,出院时血氧水平≥93%,一般情况良好。
{"title":"Combination Therapy of ReciGen Interferon, Methylprednisolone, and Sovodak as a Candidate for Treatment of Patients With Severe COVID-19 in Iran: A Case Series","authors":"Z. Kamiab, Ali Esmaeili Nadimi, F. Bahrehmand","doi":"10.34172/hpr.2022.07","DOIUrl":"https://doi.org/10.34172/hpr.2022.07","url":null,"abstract":"Introduction: During the current worldwide pandemic of coronavirus disease 2019 (CPVID-19), this disease was first identified in Iran at the end of February. This study was conducted to examine patients with severe COVID-19 disease, who were treated with three medications, namely ReciGen, methylprednisolone, and Sovodak. Case Presentation: We identified 10 patients (3 males and 7 females) with the mean (±SD) age of 55.70±21.48 years, who were admitted to the only referral hospital in Rafsanjan County (Iran) from March to July 2020 with confirmed infections with severe COVID-19. They were treated with the combination therapy of subcutaneous ReciGen interferon every other day, methylprednisolone at a dose of 250 mg every 6 hours for 5 days, and one tablet of Sovodak daily. Conclusion: In the series of cases investigated in this study, the general conditions of all patients improved in terms of their clinical parameters after receiving the combination therapy, and all patients were discharged with a blood oxygen level of≥93% and in good general conditions.","PeriodicalId":32113,"journal":{"name":"Hospital Practices and Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79947724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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