Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-382-387
A. N. Nechiporenko, D. M. Vasilevich, G. V. Yutsevich, N. A. Nechiporenko
Background. Acute purulent bilateral pyelonephritis is the most severe form of acute pyelonephritis. The disease is often accompanied with oligo- or anuria and is complicated by urosepsis. Purpose of the study. To analyze information content of diagnostic methods and immediate results of treatment of patients with acute bilateral pyelonephritis in the phase of purulent inflammation. Material and methods. 44 patients with acute bilateral pyelonephritis were observed. The purulent process in both kidneys was diagnosed by ultrasound and contrast-enhanced computed tomography (CT). Urosepsis was laboratory confirmed in 34 patients. All patients were operated on both sides. Organ-preserving surgeries were performed in 43 cases, and both kidneys were removed in one patient. Histological examination of fragments of the kidney parenchyma confirmed the purulent process in 41 patients. After surgery all patients received targeted antibacterial and detoxification therapy. Results. After operations 5 patients died due to the progression of multiple organ failure. After surgery two patients required hemodialysis due to the development of anuria. 37 patients were discharged from the clinic in a satisfactory condition. 1 year after the operation 19 were diagnosed with chronic renal failure stage III. Conclusions. 1. CT with contrast enhancement is the best method for detecting foci of purulent destruction in the renal parenchyma. 2. Acute purulent bilateral pyelonephritis in 77.3% is complicated by urosepsis which requires intensive complex treatment: surgical debridement of purulent foci in both kidneys followed by long-term targeted antibacterial and detoxication therapy. 3. The prognosis for acute purulent bilateral pyelonephritis is always uncertain for life and poor for recovery.
{"title":"ACUTE PURULENT BILATERAL PYELONEPHRITIS: DIAGNOSIS AND TREATMENT","authors":"A. N. Nechiporenko, D. M. Vasilevich, G. V. Yutsevich, N. A. Nechiporenko","doi":"10.25298/2221-8785-2023-21-4-382-387","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-382-387","url":null,"abstract":"Background. Acute purulent bilateral pyelonephritis is the most severe form of acute pyelonephritis. The disease is often accompanied with oligo- or anuria and is complicated by urosepsis. Purpose of the study. To analyze information content of diagnostic methods and immediate results of treatment of patients with acute bilateral pyelonephritis in the phase of purulent inflammation. Material and methods. 44 patients with acute bilateral pyelonephritis were observed. The purulent process in both kidneys was diagnosed by ultrasound and contrast-enhanced computed tomography (CT). Urosepsis was laboratory confirmed in 34 patients. All patients were operated on both sides. Organ-preserving surgeries were performed in 43 cases, and both kidneys were removed in one patient. Histological examination of fragments of the kidney parenchyma confirmed the purulent process in 41 patients. After surgery all patients received targeted antibacterial and detoxification therapy. Results. After operations 5 patients died due to the progression of multiple organ failure. After surgery two patients required hemodialysis due to the development of anuria. 37 patients were discharged from the clinic in a satisfactory condition. 1 year after the operation 19 were diagnosed with chronic renal failure stage III. Conclusions. 1. CT with contrast enhancement is the best method for detecting foci of purulent destruction in the renal parenchyma. 2. Acute purulent bilateral pyelonephritis in 77.3% is complicated by urosepsis which requires intensive complex treatment: surgical debridement of purulent foci in both kidneys followed by long-term targeted antibacterial and detoxication therapy. 3. The prognosis for acute purulent bilateral pyelonephritis is always uncertain for life and poor for recovery.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-364-367
M. A. Matlakova
Background. An adequate assessment of the pathogenesis and course of acute respiratory distress syndrome (ARDS), as well as the search for new methods of treating this pathology, are urgent tasks of modern medicine. The aim of the study was to reveal the influence of ribonuclease enzymes (RNases) on the pathological process of ARDS. Material and methods. Lipopolysaccharide from Escherichia Coli and Pseudomonas Aeruginosa, thromboplastincalcium mixture solution, and recombinant human RNASE2 protein were used to simulate ARDS in laboratory Wistar rats. Results. The resulting models of ARDS were characterized by persistent significant hemostasis disorders and an increase in the level of cytokines; a fragment of human ribonuclease had an impact on the change in the levels of thrombin time, activated partial thromboplastin time and interleukin-6 in the studied models. Conclusions. The changes observed in experimental animals indicate the influence of ribonucleases on the course of the pathological process in ARDS, and the presented models allow us to evaluate the relationship of the selected factors with various outcomes.
{"title":"THE ROLE OF RIBONUCLEASES IN THE IMMUNOPATHOGENESIS OF EXPERIMENTAL ACUTE RESPIRATORY DISTRESS SYNDROME","authors":"M. A. Matlakova","doi":"10.25298/2221-8785-2023-21-4-364-367","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-364-367","url":null,"abstract":"Background. An adequate assessment of the pathogenesis and course of acute respiratory distress syndrome (ARDS), as well as the search for new methods of treating this pathology, are urgent tasks of modern medicine. The aim of the study was to reveal the influence of ribonuclease enzymes (RNases) on the pathological process of ARDS. Material and methods. Lipopolysaccharide from Escherichia Coli and Pseudomonas Aeruginosa, thromboplastincalcium mixture solution, and recombinant human RNASE2 protein were used to simulate ARDS in laboratory Wistar rats. Results. The resulting models of ARDS were characterized by persistent significant hemostasis disorders and an increase in the level of cytokines; a fragment of human ribonuclease had an impact on the change in the levels of thrombin time, activated partial thromboplastin time and interleukin-6 in the studied models. Conclusions. The changes observed in experimental animals indicate the influence of ribonucleases on the course of the pathological process in ARDS, and the presented models allow us to evaluate the relationship of the selected factors with various outcomes.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-388-392
A.-M. V. Yerofeyeva
Background. The study of the role of cannabinoid CB2 receptors in the effectiveness of adipose-derived (AD) mesenchymal stem cells (MSCs) in preventing motor activity disorders in the affected limb will deepen understanding of the mechanisms of MSCs effects when administered locally. Aim. To evaluate the effect of pharmacological stimulation of cannabinoid CB2 receptors during transplantation of AD MSCs on changes in gait parameters in rats in a model of peripheral neuropathy. Material and methods. In 40 male Wistar rats peripheral neuropathic pain was modeled by sciatic nerve transection. On the 7th day after NP modeling, AD MSCs transplantation was performed without additional interventions upon the pharmacological stimulation of CB2 receptors in the area of sciatic nerve transection, as well as after stimulation of CB2 receptors on the AD MSCs membranes during pretreatment. Within 90 days a detailed analysis of the gait was carried out using the CatWalk XT 10.6. Results. Transplantation of AD MSCs accelerated the recovery of dynamic gait parameters, as well as sciatic functional index, and abolished the development of static gait disturbances in rats after sciatic nerve transection. Significant differences in the analyzed gait parameters in the study groups with AD MSCs transplantation were not found. Conclusion. Pharmacological stimulation of CB2 receptors did not enhance or suppress the effect of AD MSCs on the rate of recovery of gait parameters in experimental animals.
{"title":"GAIT PARAMETERS OF RATS WITH PERIPHERAL NEUROPATY AFTER MESENCHYMAL STEM CELL TRANSPLANTATION AND PHARMACOLOGICAL STIMULATION OF TYPE II CANNABINOID RECEPTORS","authors":"A.-M. V. Yerofeyeva","doi":"10.25298/2221-8785-2023-21-4-388-392","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-388-392","url":null,"abstract":"Background. The study of the role of cannabinoid CB2 receptors in the effectiveness of adipose-derived (AD) mesenchymal stem cells (MSCs) in preventing motor activity disorders in the affected limb will deepen understanding of the mechanisms of MSCs effects when administered locally. Aim. To evaluate the effect of pharmacological stimulation of cannabinoid CB2 receptors during transplantation of AD MSCs on changes in gait parameters in rats in a model of peripheral neuropathy. Material and methods. In 40 male Wistar rats peripheral neuropathic pain was modeled by sciatic nerve transection. On the 7th day after NP modeling, AD MSCs transplantation was performed without additional interventions upon the pharmacological stimulation of CB2 receptors in the area of sciatic nerve transection, as well as after stimulation of CB2 receptors on the AD MSCs membranes during pretreatment. Within 90 days a detailed analysis of the gait was carried out using the CatWalk XT 10.6. Results. Transplantation of AD MSCs accelerated the recovery of dynamic gait parameters, as well as sciatic functional index, and abolished the development of static gait disturbances in rats after sciatic nerve transection. Significant differences in the analyzed gait parameters in the study groups with AD MSCs transplantation were not found. Conclusion. Pharmacological stimulation of CB2 receptors did not enhance or suppress the effect of AD MSCs on the rate of recovery of gait parameters in experimental animals.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-368-373
S. A. Lialikau, P. V. Kleschenko, E. V. Kotova, N. V. Markevich, O. A. Toker, T. N. Grinevich
Background. In the Republic of Belarus, allergic diseases affect from 10 to 15% of the population, and there is a steady increase in the incidence of allergic rhinitis (AR) and bronchial asthma (BA). The purpose of the study was to evaluate the effect of gender and age on the nature of sensitization to inhalation allergens in residents of the Grodno region suffering from AR, BA and a combination of these diseases (AR + BA). Material and methods. Based on the results of skin prick tests with household, epidermal and pollen allergens, we analyzed the sensitization profiles of 237 patients (97 women, 140 men) suffering from AR (101 patients), BA (89 patients) and AR + BA (57 patients). Results. In AR, men are statistically significantly more likely than women (with a frequency exceeding 50%) to develop sensitization to cereals and early flowering trees, while household allergens are major for female representatives. In patients with BA, sensitization to household allergens, pollen of cereals and trees / shrubs is detected more often, while gender differences in the sensitization profile are less pronounced than in AR: in men, allergy to house dust is somewhat more common, and women are significantly more likely to be allergic to ash pollen. When BA is combined with AR, the sensitization profile is similar to that in patients with isolated BA: allergy to house dust, pollen of cereals and trees is detected most often, and gender differences are also slightly expressed: sensitization to epidermal allergens is significantly more common in women than in men, while sensitization to the pollen of timothy grass and creeping wheatgrass occurs less often. Conclusions. The gender of patients with BA and/or AR significantly affects the spectrum of causally significant allergens.
{"title":"INFLUENCE OF GENDER ON THE FREQUENCY OF SENSITIZATION TO INHALATION ALLERGENS IN ALLERGIC RHINITIS, BRONCHIAL ASTHMA AND THEIR COMBINATION","authors":"S. A. Lialikau, P. V. Kleschenko, E. V. Kotova, N. V. Markevich, O. A. Toker, T. N. Grinevich","doi":"10.25298/2221-8785-2023-21-4-368-373","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-368-373","url":null,"abstract":"Background. In the Republic of Belarus, allergic diseases affect from 10 to 15% of the population, and there is a steady increase in the incidence of allergic rhinitis (AR) and bronchial asthma (BA). The purpose of the study was to evaluate the effect of gender and age on the nature of sensitization to inhalation allergens in residents of the Grodno region suffering from AR, BA and a combination of these diseases (AR + BA). Material and methods. Based on the results of skin prick tests with household, epidermal and pollen allergens, we analyzed the sensitization profiles of 237 patients (97 women, 140 men) suffering from AR (101 patients), BA (89 patients) and AR + BA (57 patients). Results. In AR, men are statistically significantly more likely than women (with a frequency exceeding 50%) to develop sensitization to cereals and early flowering trees, while household allergens are major for female representatives. In patients with BA, sensitization to household allergens, pollen of cereals and trees / shrubs is detected more often, while gender differences in the sensitization profile are less pronounced than in AR: in men, allergy to house dust is somewhat more common, and women are significantly more likely to be allergic to ash pollen. When BA is combined with AR, the sensitization profile is similar to that in patients with isolated BA: allergy to house dust, pollen of cereals and trees is detected most often, and gender differences are also slightly expressed: sensitization to epidermal allergens is significantly more common in women than in men, while sensitization to the pollen of timothy grass and creeping wheatgrass occurs less often. Conclusions. The gender of patients with BA and/or AR significantly affects the spectrum of causally significant allergens.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-374-381
A. V. Zenchenko, Yu. M. Cherniakova
Background. Restoration of finger flexor tendons in fibro-osseous canals in the long term after injury is a difficult task due to scarring blockage and the impossibility of early active rehabilitation. Therefore, it is important to develop methods for durable tendon reconstruction that can provide early rehabilitation of patients without the risk of rupture of the suture zone. Aim. To evaluate the clinical effectiveness of surgeries on the flexor tendons of fingers in case of chronic injuries in fibro-osseous canals with the creation of strong connections in the sutured zone. Material and methods. The study included 66 patients with chronic injuries of 104 flexor tendons in fibro-osseous canals of the fingers. The main group consisted of 29 patients who underwent restoration of 47 tendons using new methods within 3 to 11 weeks after injury: subgroup A included 23 cases of reconstruction of the deep flexor tendon with a hidden transosseous suture in zone I; subgroup B included 24 sutures with isolation with dissected polymeric tube in zone II. Control group included 37 patients with tendon injuries on 49 fingers within fibro-osseous canals with injury term from 3 weeks to 30 years who underwent classical surgeries: secondary flexor digitorum profundus suture on 31 fingers, 2-stage tendoplasty – on 13, distal phalanx tenodesis – on 4 and reinsertion by Bunnell – on 1 finger. Also, as a control, 8 fingers were evaluated in 7 patients of the main group on which 4 secondary sutures, 2 tendoplasties and 2 tenodeses were performed. Finger function was determined by J.W. Strickland before 3, 6 months and 1 year after surgery, qualitative parameters were analyzed using two-tailed Fisher's exact test. Hand function was evaluated using the DASH questionnaire before surgery and 1 year later, the significance of differences was checked using the Mann-Whitney U-test. Results. The use of durable tendon reconstruction methods in patients of the main group enables to obtain results on average in 3 months similar to the results of 2-stage tendoplasty 10-12 months after the start of treatment in the control group. The results of reinsertion with a hidden transosseous suture and suture with temporary isolation with dissected polymer tubes did not differ significantly in terms of the degree of range of motion recovery and hand function assessment by patients. Conclusions. The developed methods showed better results in restoring the function of the fingers in comparison with classical surgeries. A strong tendon connection combined with an early start of movement increases the number of good and excellent functional outcomes and ensures patients’ satisfaction with treatment results.
{"title":"RESULTS OF SURGERY OF CHRONIC FINGER FLEXOR TENDONS INJURIES IN FIBRO-OSSEOUS CANALS","authors":"A. V. Zenchenko, Yu. M. Cherniakova","doi":"10.25298/2221-8785-2023-21-4-374-381","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-374-381","url":null,"abstract":"Background. Restoration of finger flexor tendons in fibro-osseous canals in the long term after injury is a difficult task due to scarring blockage and the impossibility of early active rehabilitation. Therefore, it is important to develop methods for durable tendon reconstruction that can provide early rehabilitation of patients without the risk of rupture of the suture zone. Aim. To evaluate the clinical effectiveness of surgeries on the flexor tendons of fingers in case of chronic injuries in fibro-osseous canals with the creation of strong connections in the sutured zone. Material and methods. The study included 66 patients with chronic injuries of 104 flexor tendons in fibro-osseous canals of the fingers. The main group consisted of 29 patients who underwent restoration of 47 tendons using new methods within 3 to 11 weeks after injury: subgroup A included 23 cases of reconstruction of the deep flexor tendon with a hidden transosseous suture in zone I; subgroup B included 24 sutures with isolation with dissected polymeric tube in zone II. Control group included 37 patients with tendon injuries on 49 fingers within fibro-osseous canals with injury term from 3 weeks to 30 years who underwent classical surgeries: secondary flexor digitorum profundus suture on 31 fingers, 2-stage tendoplasty – on 13, distal phalanx tenodesis – on 4 and reinsertion by Bunnell – on 1 finger. Also, as a control, 8 fingers were evaluated in 7 patients of the main group on which 4 secondary sutures, 2 tendoplasties and 2 tenodeses were performed. Finger function was determined by J.W. Strickland before 3, 6 months and 1 year after surgery, qualitative parameters were analyzed using two-tailed Fisher's exact test. Hand function was evaluated using the DASH questionnaire before surgery and 1 year later, the significance of differences was checked using the Mann-Whitney U-test. Results. The use of durable tendon reconstruction methods in patients of the main group enables to obtain results on average in 3 months similar to the results of 2-stage tendoplasty 10-12 months after the start of treatment in the control group. The results of reinsertion with a hidden transosseous suture and suture with temporary isolation with dissected polymer tubes did not differ significantly in terms of the degree of range of motion recovery and hand function assessment by patients. Conclusions. The developed methods showed better results in restoring the function of the fingers in comparison with classical surgeries. A strong tendon connection combined with an early start of movement increases the number of good and excellent functional outcomes and ensures patients’ satisfaction with treatment results.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-400-406
L. V. Hryntsevich, T. V. Liopo, T. N. Sokolova
The article presents an analysis of the epidemiological situation of meningococcal infection in the Grodno region over the past five years. Aim. Analysis of the dynamics of morbidity and factors affecting the frequency of meningococcal infection in the Grodno region. Material and methods. A retrospective comparative analysis of the morbidity of the population of the Grodno region was carried out using statistical reporting forms of the database of the Grodno Regional Center for Hygiene, Epidemiology and Public Health, as well as an analysis of the medical histories of the Grodno Regional Infectious Clinical Hospital and the Grodno Regional Children's Clinical Hospital. Results. An analysis of the epidemiological situation in the Grodno region over the past five years has revealed fluctuations in morbidity rates, the replacement of leading strains of meningococci, concomitant diseases in patients, the "maturation" of meningococcal infection: children account for about 61.5% of cases of generalized forms of meningococcal infection which is less than the usual 75-80%. Conclusions: Over the past five years, there has been a decrease in the incidence of meningococcal infection in the Grodno region. The epidemic situation in general for meningococcal infection in the Grodno region for the period 2018–2022 is characterized by signs of an interepidemic period, i.e. sporadic morbidity persists. The leading serotypes in patients are meningococci of serogroup B and C. In the structure of patients with generalized forms of meningococcal infection, a group of homeschooled children prevails. Concomitant chronic diseases were registered in most patients.
{"title":"EPIDEMIOLOGY OF MENINGOCOCCAL INFECTION IN THE GRODNO REGION IN 2018-2022","authors":"L. V. Hryntsevich, T. V. Liopo, T. N. Sokolova","doi":"10.25298/2221-8785-2023-21-4-400-406","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-400-406","url":null,"abstract":"The article presents an analysis of the epidemiological situation of meningococcal infection in the Grodno region over the past five years. Aim. Analysis of the dynamics of morbidity and factors affecting the frequency of meningococcal infection in the Grodno region. Material and methods. A retrospective comparative analysis of the morbidity of the population of the Grodno region was carried out using statistical reporting forms of the database of the Grodno Regional Center for Hygiene, Epidemiology and Public Health, as well as an analysis of the medical histories of the Grodno Regional Infectious Clinical Hospital and the Grodno Regional Children's Clinical Hospital. Results. An analysis of the epidemiological situation in the Grodno region over the past five years has revealed fluctuations in morbidity rates, the replacement of leading strains of meningococci, concomitant diseases in patients, the \"maturation\" of meningococcal infection: children account for about 61.5% of cases of generalized forms of meningococcal infection which is less than the usual 75-80%. Conclusions: Over the past five years, there has been a decrease in the incidence of meningococcal infection in the Grodno region. The epidemic situation in general for meningococcal infection in the Grodno region for the period 2018–2022 is characterized by signs of an interepidemic period, i.e. sporadic morbidity persists. The leading serotypes in patients are meningococci of serogroup B and C. In the structure of patients with generalized forms of meningococcal infection, a group of homeschooled children prevails. Concomitant chronic diseases were registered in most patients.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-412-415
N. V. Hlutkina, A. I. Matveychik, L. V. Kareva, E. Ya. Kulaga, O. I. Guzaevskaya, T. V. Dobrovolskaya, I. A. Myatleva, A. N. Yaroshenko
A clinical case of observation of a patient with a rare case of the Swyer-James-McLeod syndrome: postinflammatory stenosis of the left upper lobe bronchus, emphysema of the upper lobe of the left lung is presented. The difficulties of making a diagnosis of this nosological form with the analysis of the X-ray archive are analyzed. Based on the given example of a clinical case the need for timely diagnosis of the Swyer-James-McLeod syndrome is demonstrated.
{"title":"SWYER-JAMES-MCLEOD SYNDROME: POSTINFLAMMATORY STENOSIS OF THE LEFT UPPER LOBE BRONCHUS, EMPHYSEMA OF THE UPPER LOBE OF THE LEFT LUNG (CLINICAL CASE)","authors":"N. V. Hlutkina, A. I. Matveychik, L. V. Kareva, E. Ya. Kulaga, O. I. Guzaevskaya, T. V. Dobrovolskaya, I. A. Myatleva, A. N. Yaroshenko","doi":"10.25298/2221-8785-2023-21-4-412-415","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-412-415","url":null,"abstract":"A clinical case of observation of a patient with a rare case of the Swyer-James-McLeod syndrome: postinflammatory stenosis of the left upper lobe bronchus, emphysema of the upper lobe of the left lung is presented. The difficulties of making a diagnosis of this nosological form with the analysis of the X-ray archive are analyzed. Based on the given example of a clinical case the need for timely diagnosis of the Swyer-James-McLeod syndrome is demonstrated.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-327-336
O. V. Stanko, R. E. Yakubtsevich, A. A. Balla, A. V. Dubrovschik
Effective treatment of Intensive Care Unit patients is closely related to the requirement to create a temporary or permanent vascular access for renal replacement therapy, infusion and transfusion therapy and monitoring the patient's condition. The devices used for this purpose – intravascular catheters – are a potential threat to the patient, as they create the possibility of microorganisms’ access to the systemic bloodstream, by successfully negating the natural defense mechanisms. The review considers significant factors and pathogenetic mechanisms leading to the realization of infection potential in the presence of a vascular catheter in the bloodstream – catheter-associated infection, as well as diagnostic possibilities, approaches to pathogenetically justified therapy and complex prevention with regard to the achievements of modern medical science and practice.
{"title":"CATHETER-ASSOCIATED BLOODSTREAM INFECTIONS IN INTENSIVE CARE: CURRENT STATUS OF THE PROBLEM","authors":"O. V. Stanko, R. E. Yakubtsevich, A. A. Balla, A. V. Dubrovschik","doi":"10.25298/2221-8785-2023-21-4-327-336","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-327-336","url":null,"abstract":"Effective treatment of Intensive Care Unit patients is closely related to the requirement to create a temporary or permanent vascular access for renal replacement therapy, infusion and transfusion therapy and monitoring the patient's condition. The devices used for this purpose – intravascular catheters – are a potential threat to the patient, as they create the possibility of microorganisms’ access to the systemic bloodstream, by successfully negating the natural defense mechanisms. The review considers significant factors and pathogenetic mechanisms leading to the realization of infection potential in the presence of a vascular catheter in the bloodstream – catheter-associated infection, as well as diagnostic possibilities, approaches to pathogenetically justified therapy and complex prevention with regard to the achievements of modern medical science and practice.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135248304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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