Pub Date : 2023-11-08DOI: 10.25298/2221-8785-2023-21-5-520-524
N. E. Khilmonchik
This year marks the 105th anniversary of the birth of the outstanding scientist, historian of medicine and public figure Grigory Romanovich Kryuchok. His contribution to the development of medicine in Belarus cannot be underestimated, because he not only created the basis for historical medical science in the country, but also left an indelible mark in the field of practical health care. Working at the Grodno Medical Institute as the head of the department of social hygiene and healthcare organization from December 1982 to September 1986, G. R. Kryuchok worked to create a museum of the history of medicine in the Grodno region. The scientific activity of Grigory Romanovich at the Grodno Medical Institute was multifaceted. The restoration of the activities of the Grodno Scientific Society of Medical Historians was important for the medical community of Grodno.
今年是杰出的科学家、医学历史学家和公众人物格里戈里·罗曼诺维奇·克留乔克诞辰105周年。他对白俄罗斯医学发展的贡献不容低估，因为他不仅为该国的历史医学奠定了基础，而且在实际保健领域留下了不可磨灭的印记。G. R. Kryuchok于1982年12月至1986年9月在格罗德诺医学研究所工作，担任社会卫生和保健组织部门的负责人，他致力于在格罗德诺地区建立一个医学史博物馆。格罗德诺医学研究所的格里戈里·罗曼诺维奇的科学活动是多方面的。恢复格罗德诺医学历史学家科学学会的活动对格罗德诺医学界来说非常重要。
{"title":"KRYUCHOK GRIGORY ROMANOVICH – FOUNDER OF HISTORY OF MEDICINE IN BELARUS AS A SCIENCE","authors":"N. E. Khilmonchik","doi":"10.25298/2221-8785-2023-21-5-520-524","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-5-520-524","url":null,"abstract":"This year marks the 105th anniversary of the birth of the outstanding scientist, historian of medicine and public figure Grigory Romanovich Kryuchok. His contribution to the development of medicine in Belarus cannot be underestimated, because he not only created the basis for historical medical science in the country, but also left an indelible mark in the field of practical health care. Working at the Grodno Medical Institute as the head of the department of social hygiene and healthcare organization from December 1982 to September 1986, G. R. Kryuchok worked to create a museum of the history of medicine in the Grodno region. The scientific activity of Grigory Romanovich at the Grodno Medical Institute was multifaceted. The restoration of the activities of the Grodno Scientific Society of Medical Historians was important for the medical community of Grodno.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"61 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.25298/2221-8785-2023-21-5-443-452
E. S. Biletskaya, V. V. Zinchuk
The analysis of literature and our own data on the study of the mechanisms of the physiological action of ozone on the erythrocyte link of the blood was carried out. The present article discusses the effect of ozone on the oxygenbinding capacity of blood and its pro-oxidant-antioxidant balance. The effect of this gas manifests itself in different ways under conditions of changing activity of the system of gas transmitters (nitrogen monoxide and hydrogen sulfide) and at different values of the partial pressure of oxygen and carbon dioxide. The antihypoxic effect of ozone is provided with the participation of gas transmitters that realize their action through intraerythrocytic mechanisms of formation of hemoglobin affinity for oxygen, which justifies its use as a means of improving the adaptive and antihypoxic capabilities of the body.
{"title":"THE ROLE OF OZONE IN ADAPTIVE CHANGES IN THE ERYTHROCYTE LINK","authors":"E. S. Biletskaya, V. V. Zinchuk","doi":"10.25298/2221-8785-2023-21-5-443-452","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-5-443-452","url":null,"abstract":"The analysis of literature and our own data on the study of the mechanisms of the physiological action of ozone on the erythrocyte link of the blood was carried out. The present article discusses the effect of ozone on the oxygenbinding capacity of blood and its pro-oxidant-antioxidant balance. The effect of this gas manifests itself in different ways under conditions of changing activity of the system of gas transmitters (nitrogen monoxide and hydrogen sulfide) and at different values of the partial pressure of oxygen and carbon dioxide. The antihypoxic effect of ozone is provided with the participation of gas transmitters that realize their action through intraerythrocytic mechanisms of formation of hemoglobin affinity for oxygen, which justifies its use as a means of improving the adaptive and antihypoxic capabilities of the body.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"5 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.25298/2221-8785-2023-21-5-434-442
V. A. Snezhitskiy, N. V. Bukvalnaya, L. V. Yakubova
Paroxysmal atrial fibrillation can progress over time to stable forms, which is associated with an increased risk of adverse events and outcomes. The use of prediction tools for arrhythmia progression may be useful in identifying highrisk patients. The review considers eight scales for stratifying the risk of atrial fibrillation progression, alongside with their comparative analysis. The main risk factors for arrhythmia recurrence and its transition to a permanent form are described. The obtained results show that these scales are characterized by the heterogeneity of the assessed variables, which dictates the need to create new diagnostic tools.
{"title":"RISK STRATIFICATION OF ATRIAL FIBRILLATION PROGRESSION","authors":"V. A. Snezhitskiy, N. V. Bukvalnaya, L. V. Yakubova","doi":"10.25298/2221-8785-2023-21-5-434-442","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-5-434-442","url":null,"abstract":"Paroxysmal atrial fibrillation can progress over time to stable forms, which is associated with an increased risk of adverse events and outcomes. The use of prediction tools for arrhythmia progression may be useful in identifying highrisk patients. The review considers eight scales for stratifying the risk of atrial fibrillation progression, alongside with their comparative analysis. The main risk factors for arrhythmia recurrence and its transition to a permanent form are described. The obtained results show that these scales are characterized by the heterogeneity of the assessed variables, which dictates the need to create new diagnostic tools.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"38 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.25298/2221-8785-2023-21-5-515-519
A. A. Stenko, L. N. Hushchyna
The article reflects the achievements of the Faculty for International Students at the Grodno State Medical University over the past 10 years. Positions on the world stage, results in training of medical professionals for the foreign countries, successes in organizational and administrative activities, educational and methodological work, extra-curricular activities are presented.
{"title":"THE FACULTY FOR INTERNATIONAL STUDENTS: RESULTS AND ACHIEVEMENT","authors":"A. A. Stenko, L. N. Hushchyna","doi":"10.25298/2221-8785-2023-21-5-515-519","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-5-515-519","url":null,"abstract":"The article reflects the achievements of the Faculty for International Students at the Grodno State Medical University over the past 10 years. Positions on the world stage, results in training of medical professionals for the foreign countries, successes in organizational and administrative activities, educational and methodological work, extra-curricular activities are presented.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"61 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-407-411
E. S. Lisok, I. A. Naumau
Background. Work specifics of general practitioners forms occupational risk for disorders in their health. The aim of the study is to assess from a hygienic point of view the occupational risk and predictive effects of health disorders development of general practitioners. Material and methods. Occupational risk and predictive effects of health disorders was evaluated on the basis of a hygienic assessment of working conditions applying standard methodological approaches. Results. We have established that harmful working conditions (class 3.2) at workplaces of general practitioners are mainly formed under the influence of a biological factor of the working environment. Conclusions. The degree of the occupational risk of health disorders of general practitioners currently assessed as “medium” cannot be completely recognized as corresponding to the prevailing working conditions since the methodology for assessing working conditions requires improved relevant criterial approaches.
{"title":"HYGIENIC ASSESSMENT OF OCCUPATIONAL RISK AND PREDICTIVE EFFECTS OF HEALTH DISORDERS DEVELOPMENT OF GENERAL PRACTITIONERS","authors":"E. S. Lisok, I. A. Naumau","doi":"10.25298/2221-8785-2023-21-4-407-411","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-407-411","url":null,"abstract":"Background. Work specifics of general practitioners forms occupational risk for disorders in their health. The aim of the study is to assess from a hygienic point of view the occupational risk and predictive effects of health disorders development of general practitioners. Material and methods. Occupational risk and predictive effects of health disorders was evaluated on the basis of a hygienic assessment of working conditions applying standard methodological approaches. Results. We have established that harmful working conditions (class 3.2) at workplaces of general practitioners are mainly formed under the influence of a biological factor of the working environment. Conclusions. The degree of the occupational risk of health disorders of general practitioners currently assessed as “medium” cannot be completely recognized as corresponding to the prevailing working conditions since the methodology for assessing working conditions requires improved relevant criterial approaches.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-393-399
R. I. Dovnar
Background. To develop effective means of combating pathogenic microflora, as well as effective etiotropic treatment it is necessary to know the structure and emerging trends of surgical infection pathogens. Aim of the research – assessment of the structure and current dynamics of changes in the microbiological spectrum of causative agents of purulent processes in soft tissues of surgical patients at the present time. Material and methods. The results of microbiological cultures taken in the departments: surgical, burn, traumatology № 3 and anesthesiology, resuscitation and intensive care of the Emergency hospital in Grodno from 2016 to 2022 were analyzed. The microbiological spectrum of purulent diseases of soft tissues was compared with the results of cultures of all microflora isolated from patients of the studied departments to identify existing trends in pathogenic microflora in the hospital. Results. Despite the fact that the pathogenic microflora isolated from surgical patients was very diverse, most often Staphylococcus aureus was cultured from Gram-positive microorganisms, and Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii and Proteus mirabilis were cultured from Gram-negative microorganisms. A fungus of the genus Candida (Candida spp.) was cultured in a small but practically stable ratio of about 1 %. At the same time, there are no significant changes in the structure of the circulation of the leading microflora in patients with purulent processes of soft tissues over the studied period of time. Conclusions. The structure of the cultured microbial flora of the studied surgical departments, as a whole, when compared with microbes isolated from patients with purulent processes of soft tissues is almost identical. There are no significant changes in its structure in these patients. The most significant cultured organisms were Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii and Proteus mirabilis.
{"title":"STRUCTURE AND DYNAMICS OF CHANGES IN MICROFLORA OF PURULENT DISEASES OF SOFT TISSUES OF PATIENTS OF SURGICAL DEPARTMENTS IN MODERN CONDITIONS","authors":"R. I. Dovnar","doi":"10.25298/2221-8785-2023-21-4-393-399","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-393-399","url":null,"abstract":"Background. To develop effective means of combating pathogenic microflora, as well as effective etiotropic treatment it is necessary to know the structure and emerging trends of surgical infection pathogens. Aim of the research – assessment of the structure and current dynamics of changes in the microbiological spectrum of causative agents of purulent processes in soft tissues of surgical patients at the present time. Material and methods. The results of microbiological cultures taken in the departments: surgical, burn, traumatology № 3 and anesthesiology, resuscitation and intensive care of the Emergency hospital in Grodno from 2016 to 2022 were analyzed. The microbiological spectrum of purulent diseases of soft tissues was compared with the results of cultures of all microflora isolated from patients of the studied departments to identify existing trends in pathogenic microflora in the hospital. Results. Despite the fact that the pathogenic microflora isolated from surgical patients was very diverse, most often Staphylococcus aureus was cultured from Gram-positive microorganisms, and Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii and Proteus mirabilis were cultured from Gram-negative microorganisms. A fungus of the genus Candida (Candida spp.) was cultured in a small but practically stable ratio of about 1 %. At the same time, there are no significant changes in the structure of the circulation of the leading microflora in patients with purulent processes of soft tissues over the studied period of time. Conclusions. The structure of the cultured microbial flora of the studied surgical departments, as a whole, when compared with microbes isolated from patients with purulent processes of soft tissues is almost identical. There are no significant changes in its structure in these patients. The most significant cultured organisms were Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii and Proteus mirabilis.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-337-341
V. S. Nohtseu, A. V. Karavai, E. O. Patsiupa, S. N. Shapavalava
Colorectal cancer (CRC) is a common disease with a high mortality rate. CRC is the third most common disease in the world in men and the second most common disease in women, according to the World Health Organization. There is currently an increased interest in studying the relationship between the gut microbiome and the development of CRC. Changes in the gut microbiome in patients with CRC suggest a possible role of host-microbe interactions in the onset and development of this malignancy and, at the same time, open possibilities for new ways of preventing, diagnosing and treating this disease. This review aims to consider certain aspects of the influence of the gut microbiome on the development of CRC and some related diseases.
{"title":"THE ROLE OF THE GUT MICROBIOME IN THE DEVELOPMENT OF COLORECTAL CANCER AND THE OCCURENCE OF THE ANASTOMOTIC LEAK IN THE POSTOPERATIVE PERIOD","authors":"V. S. Nohtseu, A. V. Karavai, E. O. Patsiupa, S. N. Shapavalava","doi":"10.25298/2221-8785-2023-21-4-337-341","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-337-341","url":null,"abstract":"Colorectal cancer (CRC) is a common disease with a high mortality rate. CRC is the third most common disease in the world in men and the second most common disease in women, according to the World Health Organization. There is currently an increased interest in studying the relationship between the gut microbiome and the development of CRC. Changes in the gut microbiome in patients with CRC suggest a possible role of host-microbe interactions in the onset and development of this malignancy and, at the same time, open possibilities for new ways of preventing, diagnosing and treating this disease. This review aims to consider certain aspects of the influence of the gut microbiome on the development of CRC and some related diseases.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-352-363
T. P. Pronko, V. A. Snezhitskiy, A. V. Kapytski
The aim of the study was to determine the clinical and laboratory factors that determine high and low platelet reactivity in patients taking clopidogrel on day 1-2 of myocardial infarction (MI). Material and Methods. A total of 405 patients (322 men and 83 women) with MI aged 31 to 74 years were examined. Group 1 included patients with low residual platelet reactivity (LRPR) – 89 people, group 2 consisted of patients with optimal platelet reactivity (OPR) – 223 people, group 3 was composed of patients with high residual platelet reactivity (HRPR) – 93 people. Platelet aggregation was assessed on a Multiplate impedance aggregometer (Germany) with several aggregation inducers. A blood test and a study of morphometric parameters of platelets were performed by the cytoflow method on an automated hematology analyzer Sysmex XS-500i (Japan). The study of the level of soluble CD40 ligand (sСD40L) and sP-selectin was performed in 140 patients, von Willebrand factor (VWF) and endothelin-1 were assessed in 150 people on the enzyme immunoassay analyzer Sunrise (TECAN, Austria) using Fine Biotech kits (China). All studies were performed upon admission to the hospital on day 1-2 of MI (at least 12 hours after the administration of a loading dose of clopidogrel). Results. A one-way linear regression analysis identified the following factors that independently affect the value of the ADP-test: age (β=-0.21, 95% CI: -0.42 – -0.0095; p=0.04); total cholesterol (β=1.4, 95% CI: 0.26–2.56; p=0.04); white blood cell count (β= 0.57, 95% CI: 0.003–1.14; p=0.049); hemoglobin (β=-0.16, 95% CI: -0.27 – -0.044; p=0.0067); platelet count (β=1.4, 95% CI: 0.26 – 2.56; p=0.04); PCT (β=76.8, 95% CI: 41.5 – 112.1; p=0.000024); TRAP-test (β=0.4, 95% CI: 0.33–0.46; p<0.000001); CD40L (β=0.044, 95% CI: 0.013–0.074; p=0.005); sP-selectin (β=2.3, 95% CI: 0.63 – 3.97; p=0.007); VWF (β=0.06, 95% CI: 0.016 – 0.11; p=0.0085). To determine the probability of HRPR developing a binary logistic regression model was constructed based on the observational data of a sample of 398 patients, which included the following indicators: age, white blood cell count, mean platelet volume (MPV) and platelet distribution width (PDW) values, results of TRAP-test and the level of creatinine. At the probability cut-off p=0.4746, the sensitivity of the constructed model was 74.2%, specificity - 74.1%, classification accuracy – 74.1%, the area under the ROC-curve – 0.795 (CI: 0.745 – 0.844). To determine the probability of developing LRPR, a binary logistic regression model was constructed based on the observational data of 143 patients, which included the following indicators: the number of leukocytes, MPV and TRAP-test values, fibrinogen and VWF levels. With a probability cut-off p=0.5589, the sensitivity of this model was 84.6%, specificity – 77.8%, classification accuracy – 79.0%, the area under the ROC-curve – 0.826 (CI: 0.747 – 0.905). Conclusion. On days 1-2 of MI, 22% of patients with an excessive respo
{"title":"DETERMINANTS OF HIGH AND LOW PLATELET RESIDUAL REACTIVITY ON DAY 1-2 OF MYOCARDIAL INFARCTION WHEN TAKING CLOPIDOGREL","authors":"T. P. Pronko, V. A. Snezhitskiy, A. V. Kapytski","doi":"10.25298/2221-8785-2023-21-4-352-363","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-352-363","url":null,"abstract":"The aim of the study was to determine the clinical and laboratory factors that determine high and low platelet reactivity in patients taking clopidogrel on day 1-2 of myocardial infarction (MI). Material and Methods. A total of 405 patients (322 men and 83 women) with MI aged 31 to 74 years were examined. Group 1 included patients with low residual platelet reactivity (LRPR) – 89 people, group 2 consisted of patients with optimal platelet reactivity (OPR) – 223 people, group 3 was composed of patients with high residual platelet reactivity (HRPR) – 93 people. Platelet aggregation was assessed on a Multiplate impedance aggregometer (Germany) with several aggregation inducers. A blood test and a study of morphometric parameters of platelets were performed by the cytoflow method on an automated hematology analyzer Sysmex XS-500i (Japan). The study of the level of soluble CD40 ligand (sСD40L) and sP-selectin was performed in 140 patients, von Willebrand factor (VWF) and endothelin-1 were assessed in 150 people on the enzyme immunoassay analyzer Sunrise (TECAN, Austria) using Fine Biotech kits (China). All studies were performed upon admission to the hospital on day 1-2 of MI (at least 12 hours after the administration of a loading dose of clopidogrel). Results. A one-way linear regression analysis identified the following factors that independently affect the value of the ADP-test: age (β=-0.21, 95% CI: -0.42 – -0.0095; p=0.04); total cholesterol (β=1.4, 95% CI: 0.26–2.56; p=0.04); white blood cell count (β= 0.57, 95% CI: 0.003–1.14; p=0.049); hemoglobin (β=-0.16, 95% CI: -0.27 – -0.044; p=0.0067); platelet count (β=1.4, 95% CI: 0.26 – 2.56; p=0.04); PCT (β=76.8, 95% CI: 41.5 – 112.1; p=0.000024); TRAP-test (β=0.4, 95% CI: 0.33–0.46; p<0.000001); CD40L (β=0.044, 95% CI: 0.013–0.074; p=0.005); sP-selectin (β=2.3, 95% CI: 0.63 – 3.97; p=0.007); VWF (β=0.06, 95% CI: 0.016 – 0.11; p=0.0085). To determine the probability of HRPR developing a binary logistic regression model was constructed based on the observational data of a sample of 398 patients, which included the following indicators: age, white blood cell count, mean platelet volume (MPV) and platelet distribution width (PDW) values, results of TRAP-test and the level of creatinine. At the probability cut-off p=0.4746, the sensitivity of the constructed model was 74.2%, specificity - 74.1%, classification accuracy – 74.1%, the area under the ROC-curve – 0.795 (CI: 0.745 – 0.844). To determine the probability of developing LRPR, a binary logistic regression model was constructed based on the observational data of 143 patients, which included the following indicators: the number of leukocytes, MPV and TRAP-test values, fibrinogen and VWF levels. With a probability cut-off p=0.5589, the sensitivity of this model was 84.6%, specificity – 77.8%, classification accuracy – 79.0%, the area under the ROC-curve – 0.826 (CI: 0.747 – 0.905). Conclusion. On days 1-2 of MI, 22% of patients with an excessive respo","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-342-351
L. V. Yakubova, A. M. Molostova
Abstract. The number of strokes and deaths from stroke is increasing every year in the world, with ischemic stroke (IS) accounting for about 80% of cases. The purpose of this review is to analyze the results of studies evaluating the significance of measuring various biomarkers in predicting the risk of developing IS. To date, studies are actively exploring the prospects of a number of inflammatory (C-reactive protein, fibrinogen, pro-inflammatory cytokines, etc.), hemodynamic, cardiac, and metabolic biomarkers that can be used to improve the accuracy of IS risk stratification. Currently, it is difficult to isolate the screening biomarker that is the most diagnostically significant for assessing the risk of stroke. Thus, according to a number of studies and meta-analyses, highly sensitive C-reactive protein is a diagnostically significant biomarker of IS. The role of highly sensitive troponin I and natriuretic peptide in diagnosing the risk of IS requires further study. Evaluation of triglyceride-glucose index, apolipoprotein B, apolipoprotein A1, asymmetric dimethylarginine, uric acid seems promising. However, their possible role in the reclassification of asymptomatic patients in addition to the existing scales based on traditional risk factors remains to be elucidated
{"title":"BLOOD BIOMARKERS AS PREDICTORS OF ISCHEMIC STROKE: A NEW LOOK AT KNOWN MOLECULES","authors":"L. V. Yakubova, A. M. Molostova","doi":"10.25298/2221-8785-2023-21-4-342-351","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-342-351","url":null,"abstract":"Abstract. The number of strokes and deaths from stroke is increasing every year in the world, with ischemic stroke (IS) accounting for about 80% of cases. The purpose of this review is to analyze the results of studies evaluating the significance of measuring various biomarkers in predicting the risk of developing IS. To date, studies are actively exploring the prospects of a number of inflammatory (C-reactive protein, fibrinogen, pro-inflammatory cytokines, etc.), hemodynamic, cardiac, and metabolic biomarkers that can be used to improve the accuracy of IS risk stratification. Currently, it is difficult to isolate the screening biomarker that is the most diagnostically significant for assessing the risk of stroke. Thus, according to a number of studies and meta-analyses, highly sensitive C-reactive protein is a diagnostically significant biomarker of IS. The role of highly sensitive troponin I and natriuretic peptide in diagnosing the risk of IS requires further study. Evaluation of triglyceride-glucose index, apolipoprotein B, apolipoprotein A1, asymmetric dimethylarginine, uric acid seems promising. However, their possible role in the reclassification of asymptomatic patients in addition to the existing scales based on traditional risk factors remains to be elucidated","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.25298/2221-8785-2023-21-4-416-422
O. V. Zablotskaya, I. E. Atroschenko, E. P. Vorobeva
A review of approaches to the treatment and early diagnosis of kidney dysfunction in patients with arterial hypertension is presented: the relevance of the problem, causes, pathogenetic mechanisms, clinical symptoms, diagnosis, new directions in treatment and prevention.
{"title":"KIDNEY DYSFUNCTION AS A PREDICTOR OF ARTERIAL HYPERTENSION PROGRESSION","authors":"O. V. Zablotskaya, I. E. Atroschenko, E. P. Vorobeva","doi":"10.25298/2221-8785-2023-21-4-416-422","DOIUrl":"https://doi.org/10.25298/2221-8785-2023-21-4-416-422","url":null,"abstract":"A review of approaches to the treatment and early diagnosis of kidney dysfunction in patients with arterial hypertension is presented: the relevance of the problem, causes, pathogenetic mechanisms, clinical symptoms, diagnosis, new directions in treatment and prevention.","PeriodicalId":32244,"journal":{"name":"Zurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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