首页 > 最新文献

Journal of Regenerative Biology and Medicine最新文献

英文 中文
The Palliative Management of A Cancer Patient With Giant Retinoblastoma of The Left Eye 1例左眼巨大视网膜母细胞瘤的姑息治疗
Pub Date : 2021-06-01 DOI: 10.37191/MAPSCI-2582-385X-3(3)-068
S. Bittmann
We report of a young African child with a giant retinoblastoma originating from the left orbital space. The mother and the child left Cameroon seeking medical support at the Department of Pediatrics. To date of arrival, the extensive tumor was exulcerating and not curable. Only palliative support was possible.
我们报告一个年轻的非洲儿童与一个巨大的视网膜母细胞瘤起源于左眼眶空间。母亲和孩子离开喀麦隆,前往儿科寻求医疗支持。到目前为止,这个广泛的肿瘤正在溃烂,无法治愈。只有姑息治疗是可能的。
{"title":"The Palliative Management of A Cancer Patient With Giant Retinoblastoma of The Left Eye","authors":"S. Bittmann","doi":"10.37191/MAPSCI-2582-385X-3(3)-068","DOIUrl":"https://doi.org/10.37191/MAPSCI-2582-385X-3(3)-068","url":null,"abstract":"We report of a young African child with a giant retinoblastoma originating from the left orbital space. The mother and the child left Cameroon seeking medical support at the Department of Pediatrics. To date of arrival, the extensive tumor was exulcerating and not curable. Only palliative support was possible.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132572217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucormycosis: A Black Fungus- Post Covid Complications 毛霉病:一种黑色真菌-感染后并发症
Pub Date : 2021-04-03 DOI: 10.37191/mapsci-2582-385x-3(4)-078
P. Kr
Human to human transmitted disease is the game of coronavirus disease (COVID-19) transmission and it had been declared an emergency global pandemic that caused major disastrous in the respiratory system to more than five million people and killing more than half a billion deaths across the globe. Besides lower acute respiratory syndrome, there is damage to the alveolar with severe inflammatory exudation. COVID-19 patients often have lower immunosuppressive CD4+ T and CD8+ T cells and most patients in intensive care units (ICU) need mechanical ventilation, hence longer stay in hospitals. These patients have been discovered to develop fungal co-infections. COVID-19 patients develop what is known as mucormycosis a black fungal infection that is deadly leading to loss of sight and hearing and eventually death. This chapter will focus on mucormycosis, a black fungus caused during post covid complications.
人与人之间的传播疾病是冠状病毒病(COVID-19)传播的游戏,它已被宣布为紧急全球大流行,造成全球500多万人呼吸系统严重灾难,造成超过5亿人死亡。除下急性呼吸综合征外,肺泡损伤伴严重炎性渗出。COVID-19患者通常具有较低的免疫抑制性CD4+ T和CD8+ T细胞,重症监护病房(ICU)的大多数患者需要机械通气,因此住院时间更长。这些患者已被发现并发真菌感染。COVID-19患者会患上所谓的毛霉菌病,这是一种致命的黑色真菌感染,会导致视力和听力丧失,最终死亡。本章将重点介绍毛霉病,这是一种在covid后并发症期间引起的黑色真菌。
{"title":"Mucormycosis: A Black Fungus- Post Covid Complications","authors":"P. Kr","doi":"10.37191/mapsci-2582-385x-3(4)-078","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-3(4)-078","url":null,"abstract":"Human to human transmitted disease is the game of coronavirus disease (COVID-19) transmission and it had been declared an emergency global pandemic that caused major disastrous in the respiratory system to more than five million people and killing more than half a billion deaths across the globe. Besides lower acute respiratory syndrome, there is damage to the alveolar with severe inflammatory exudation. COVID-19 patients often have lower immunosuppressive CD4+ T and CD8+ T cells and most patients in intensive care units (ICU) need mechanical ventilation, hence longer stay in hospitals. These patients have been discovered to develop fungal co-infections. COVID-19 patients develop what is known as mucormycosis a black fungal infection that is deadly leading to loss of sight and hearing and eventually death. This chapter will focus on mucormycosis, a black fungus caused during post covid complications.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115025901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Editor Note- Journal of Regenerative Biology and Medicine Volume 3 Issue 2 《再生生物学与医学杂志》第三卷第2期
Pub Date : 2021-02-02 DOI: 10.37191/mapsci-2582-385x-3(2)-063
Ottorino Del Foco
As a new editorial board member of the Journal of Regenerative Biology and Medicine, I would like to introduce myself, outline some aspects of my clinical background and emphasize the challenges we face shortly regarding stem cell therapy in vascular surgery.
作为《再生生物学与医学杂志》的新编辑委员会成员,我想介绍一下我自己,概述一下我的临床背景,并强调我们在血管外科干细胞治疗方面即将面临的挑战。
{"title":"Editor Note- Journal of Regenerative Biology and Medicine Volume 3 Issue 2","authors":"Ottorino Del Foco","doi":"10.37191/mapsci-2582-385x-3(2)-063","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-3(2)-063","url":null,"abstract":"As a new editorial board member of the Journal of Regenerative Biology and Medicine, I would like to introduce myself, outline some aspects of my clinical background and emphasize the challenges we face shortly regarding stem cell therapy in vascular surgery.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132755065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alice in Wonderland Syndrome: An Update of Present Data With A Special View to Body Position, Traumatic and Genetic Aspects 爱丽丝梦游仙境综合症:当前数据的更新与身体位置,创伤和遗传方面的特殊观点
Pub Date : 2020-12-15 DOI: 10.37191/MAPSCI-2582-385X-2(6)-049
S. Bittmann
Alice in Wonderland Syndrome (AIWS) was named after the description of Lewis Carroll in his novel. In 1955, John Todd, a psychiatrist described this entity for the first time and results in a distortion of perception. Todd described it as „Alice's Adventures in Wonderland“ by Lewis Carroll. The author Carroll suffered from severe migraine attacks. Alice in Wonderland Syndrome is a disorienting condition of seizures affecting visual perception. AIWS is a neurological form of seizures influencing the brain, thereby causing a disturbed perception. Patients describe visual, auditory, and tactile hallucinations and disturbed perceptions. The causes of AIWS are still not known exactly. Cases of migraine, brain tumors, depression episodes, epilepsy, delirium, psychoactive drugs, ischemic stroke, depressive disorders, and EBV, mycoplasma, and malaria infections are correlating with AIWS like seizures. Often no EEG correlate is found. Neuroimaging studies reveal disturbances of brain regions including the temporoparietal junction, the temporal and occipital lobe as typical localization of the visual pathway. A decrease of perfusion of the visual pathways could induce these disturbances, especially in the temporal lobe in patients with AIWS. Other theories suggest distorted body illusions stem from the parietal lobe. The concrete origin of this mysterious syndrome is to date not clearly defined.
爱丽丝梦游仙境综合症(简称AIWS)是根据刘易斯·卡罗尔在其小说中的描述而命名的。1955年,精神病学家约翰·托德首次描述了这种实体,并导致了感知的扭曲。托德把它描述为刘易斯·卡罗尔的《爱丽丝梦游仙境》。作者卡罗尔患有严重的偏头痛。爱丽丝梦游仙境综合症是一种影响视觉感知的癫痫症。AIWS是一种影响大脑的癫痫发作的神经学形式,从而导致感知障碍。患者描述了视觉、听觉和触觉上的幻觉和知觉紊乱。AIWS的病因尚不清楚。偏头痛、脑肿瘤、抑郁发作、癫痫、谵妄、精神活性药物、缺血性中风、抑郁症、EBV、支原体和疟疾感染的病例与AIWS样癫痫发作相关。通常没有发现脑电图相关。神经影像学研究显示,包括颞顶叶交界处、颞叶和枕叶在内的大脑区域的紊乱是视觉通路的典型定位。视觉通路灌注减少可引起这些障碍,特别是AIWS患者的颞叶。其他理论认为,扭曲的身体幻觉源于顶叶。这种神秘综合症的具体起源至今尚未明确。
{"title":"Alice in Wonderland Syndrome: An Update of Present Data With A Special View to Body Position, Traumatic and Genetic Aspects","authors":"S. Bittmann","doi":"10.37191/MAPSCI-2582-385X-2(6)-049","DOIUrl":"https://doi.org/10.37191/MAPSCI-2582-385X-2(6)-049","url":null,"abstract":"Alice in Wonderland Syndrome (AIWS) was named after the description of Lewis Carroll in his novel. In 1955, John Todd, a psychiatrist described this entity for the first time and results in a distortion of perception. Todd described it as „Alice's Adventures in Wonderland“ by Lewis Carroll. The author Carroll suffered from severe migraine attacks. Alice in Wonderland Syndrome is a disorienting condition of seizures affecting visual perception. AIWS is a neurological form of seizures influencing the brain, thereby causing a disturbed perception. Patients describe visual, auditory, and tactile hallucinations and disturbed perceptions. The causes of AIWS are still not known exactly. Cases of migraine, brain tumors, depression episodes, epilepsy, delirium, psychoactive drugs, ischemic stroke, depressive disorders, and EBV, mycoplasma, and malaria infections are correlating with AIWS like seizures. Often no EEG correlate is found. Neuroimaging studies reveal disturbances of brain regions including the temporoparietal junction, the temporal and occipital lobe as typical localization of the visual pathway. A decrease of perfusion of the visual pathways could induce these disturbances, especially in the temporal lobe in patients with AIWS. Other theories suggest distorted body illusions stem from the parietal lobe. The concrete origin of this mysterious syndrome is to date not clearly defined.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129441169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Overall Analysis Of Covid-19 Pandemic In Germany 德国新冠肺炎大流行总体分析
Pub Date : 2020-07-10 DOI: 10.37191/mapsci-2582-385x-2(4)-0039
Bittmann S
What The COVID-19 pandemic has been present in Germany since 27 January 2020, it is the spread of the respiratory disease COVID-19, which first appeared at the end of 2019 and broke out worldwide at the beginning of 2020, triggered by infection with the coronavirus SARS-CoV-2.
自2020年1月27日以来,德国出现了COVID-19大流行,这是呼吸道疾病COVID-19的传播,该疾病于2019年底首次出现,并于2020年初在全球爆发,由冠状病毒SARS-CoV-2感染引发。
{"title":"Overall Analysis Of Covid-19 Pandemic In Germany","authors":"Bittmann S","doi":"10.37191/mapsci-2582-385x-2(4)-0039","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(4)-0039","url":null,"abstract":"What The COVID-19 pandemic has been present in Germany since 27 January 2020, it is the spread of the respiratory disease COVID-19, which first appeared at the end of 2019 and broke out worldwide at the beginning of 2020, triggered by infection with the coronavirus SARS-CoV-2.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126632488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Down Syndrome: Regenerative Medicine Taming the Over-Expressive Trisomy (Chromosome 21) Genes 唐氏综合症:再生医学驯服过度表达的三体(21号染色体)基因
Pub Date : 2020-06-07 DOI: 10.37191/mapsci-2582-385x-2(5)-040
Prithiv K R Kumar
Trisomy silencing is an important factor in curing Down syndrome. As per a study in various experiments, XIST Transgene transforms chromosome 21 in stem cells. This Transgene normalizes cell function and development upon transformation and its induction in Transgene clones corrects the overproduction of meakayocytes, stemcells, iPS cells and erythrocytes keeping the balance of hemopoietic developments. Given all these to added knowledge, our study further advanced to CD4/CD43 progenitors cells demonstrating principle proof for epigenetic based investigative strategy in pathology. Chapter basic focuses on drug discovery, delivery of drugs, administration path, dosage and frequency of transplantation. Monitor tools of MRI, MSK and PET-CT scanners. Also,the cultivation of chromosome 21 cells trisomy to disomy is relevant without genetic manipulation, chemical treatment and exposure to irradiation. Disomy or diploid cells serve to the purpose of drug screening and raw material of regenerative medicine and cell-based therapy.
三体沉默是治疗唐氏综合症的一个重要因素。根据各种实验的研究,XIST转基因转化干细胞中的21号染色体。这种转基因在转化过程中使细胞功能和发育正常化,并在转基因克隆中诱导纠正造血细胞、干细胞、iPS细胞和红细胞的过度产生,保持造血发育的平衡。考虑到这些,我们的研究进一步深入到CD4/CD43祖细胞,为病理上基于表观遗传学的研究策略提供了原理证明。基本章介绍了药物的发现、给药途径、给药剂量和移植频率。MRI, MSK和PET-CT扫描仪的监控工具。另外,21号染色体细胞三体到二体的培养不需要基因操作、化学处理和辐照。二体或二倍体细胞可用于药物筛选和再生医学及细胞基础治疗的原料。
{"title":"Down Syndrome: Regenerative Medicine Taming the Over-Expressive Trisomy (Chromosome 21) Genes","authors":"Prithiv K R Kumar","doi":"10.37191/mapsci-2582-385x-2(5)-040","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(5)-040","url":null,"abstract":"Trisomy silencing is an important factor in curing Down syndrome. As per a study in various experiments, XIST Transgene transforms chromosome 21 in stem cells. This Transgene normalizes cell function and development upon transformation and its induction in Transgene clones corrects the overproduction of meakayocytes, stemcells, iPS cells and erythrocytes keeping the balance of hemopoietic developments. Given all these to added knowledge, our study further advanced to CD4/CD43 progenitors cells demonstrating principle proof for epigenetic based investigative strategy in pathology. Chapter basic focuses on drug discovery, delivery of drugs, administration path, dosage and frequency of transplantation. Monitor tools of MRI, MSK and PET-CT scanners. Also,the cultivation of chromosome 21 cells trisomy to disomy is relevant without genetic manipulation, chemical treatment and exposure to irradiation. Disomy or diploid cells serve to the purpose of drug screening and raw material of regenerative medicine and cell-based therapy.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129001567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of TMPRSS2 and TMPRSS2- Inhibitors in Cell Entry Mechanism of COVID-19 TMPRSS2和TMPRSS2抑制剂在COVID-19细胞进入机制中的作用
Pub Date : 2020-06-01 DOI: 10.37191/mapsci-2582-385x-2(3)-026
S. Bittmann
The enzymes trypsin, furine and other proprotein convertases, cathepsin, transmembrane proteases (TMPRSS) and elastases play a role in the cell entry of coronaviruses (Coronaviridae). The proteases TMPRSS2 and TMPRSS11a, which are abundant in the respiratory tract and expressed on cell surfaces, promote the entry of SARS-CoV-1 viruses. For the TMPRSS protease TMPRSS11d - also known as human airway trypsin-like protease (HAT) - a proteolytic activation of the S- protein of SARS-CoV-1 was demonstrated. TMPRSS2, in turn, complexes with the ACE2 receptor, which allows efficient penetration of the virus directly at the cell surface. TMPRSS2 and TMPRSS11D activate the S protein by cleaving it into the S1 and S2 subunits, thus allowing endosome-independent cell entry at the cell membrane. Virus-based therapies include monoclonal antibodies, antiviral peptides that dock to the S protein of viruses, viral nucleic acid synthesis inhibitors and inhibitors for docking to other viral structures and accessory proteins.
胰蛋白酶、糠氨酸等蛋白转化酶、组织蛋白酶、跨膜蛋白酶(TMPRSS)和弹性酶在冠状病毒(冠状病毒科)进入细胞过程中发挥作用。在呼吸道中丰富并在细胞表面表达的蛋白酶TMPRSS2和TMPRSS11a促进了SARS-CoV-1病毒的进入。对于TMPRSS蛋白酶TMPRSS11d,也称为人气道胰蛋白酶样蛋白酶(HAT),证实了SARS-CoV-1的S-蛋白的蛋白水解激活。反过来,TMPRSS2与ACE2受体结合,使病毒能够直接在细胞表面有效地渗透。TMPRSS2和TMPRSS11D通过将S蛋白切割成S1和S2亚基来激活S蛋白,从而允许不依赖于内体的细胞进入细胞膜。基于病毒的治疗包括单克隆抗体、与病毒S蛋白对接的抗病毒肽、病毒核酸合成抑制剂以及与其他病毒结构和辅助蛋白对接的抑制剂。
{"title":"The Role of TMPRSS2 and TMPRSS2- Inhibitors in Cell Entry Mechanism of COVID-19","authors":"S. Bittmann","doi":"10.37191/mapsci-2582-385x-2(3)-026","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(3)-026","url":null,"abstract":"The enzymes trypsin, furine and other proprotein convertases, cathepsin, transmembrane proteases (TMPRSS) and elastases play a role in the cell entry of coronaviruses (Coronaviridae). The proteases TMPRSS2 and TMPRSS11a, which are abundant in the respiratory tract and expressed on cell surfaces, promote the entry of SARS-CoV-1 viruses. For the TMPRSS protease TMPRSS11d - also known as human airway trypsin-like protease (HAT) - a proteolytic activation of the S- protein of SARS-CoV-1 was demonstrated. TMPRSS2, in turn, complexes with the ACE2 receptor, which allows efficient penetration of the virus directly at the cell surface. TMPRSS2 and TMPRSS11D activate the S protein by cleaving it into the S1 and S2 subunits, thus allowing endosome-independent cell entry at the cell membrane. Virus-based therapies include monoclonal antibodies, antiviral peptides that dock to the S protein of viruses, viral nucleic acid synthesis inhibitors and inhibitors for docking to other viral structures and accessory proteins.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115420390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
COVID-19: ACE-2 Receptor, TMPRSS2, Cathepsin-L/B and CD-147 Receptor COVID-19: ACE-2受体、TMPRSS2、组织蛋白酶- l /B和CD-147受体
Pub Date : 2020-06-01 DOI: 10.37191/mapsci-2582-385x-2(3)-031
S. Bittmann
COVID-19 shows an extremely rapid spreading pattern, classified as SARS-CoV-2, has become a worldwide health problem. Relating to biological characteristics of SARS-CoV-2, the new viral agent was comprehensively summarized in order to optimize the date research on this novel disease and make adequate therapeutic decisions. The structure of COVID-19 virus is partially similar to SARS-CoV and MERS-CoV and to date, the origin is not clearly ruled out in detail. COVID-19 in general shows, without any adequate measurement, an exponential reproductive rate, an incubation of nearly 14 days. The clinical appearance and the pandemic spread of COVID-19 were very similar to earlier SARS epidemics. The occurrence of SARS-CoV-2; previously provisionally referred to as novel coronavirus 2019 or 2019-nCoV (COVID-19) in China in late 2019, has induced a global spreading and is a worldwide public health problem. At the end of January 2020, the World Health Organization described COVID-19 as the sixth international public health emergency. SARS-CoV-2 is similar to severe corona viruses similar to acute respiratory syndrome of bat origin, bat-SL-CoVZC45 and bat-SL-CoVZXC21. The transmission is based on by human-to-human transmission via droplets or direct contact or stool, whereas the infection seems to have an incubation period of up to 14 days and a reproduction rate of 2.24-3.58. In patients with SARS-CoV-2-induced pneumonia, fever was the prominent symptom in these patients followed by cough. Currently, stopping the rapid spreading of SARS-CoV-2 is the primary intervention in health care management. However, health authorities should continue to monitor the situation closely.
COVID-19呈现出极快的传播模式,被归类为SARS-CoV-2,已成为全球性的健康问题。结合SARS-CoV-2的生物学特性,对新病毒制剂进行综合总结,以优化这一新型疾病的研究数据,做出合理的治疗决策。COVID-19病毒的结构部分类似于SARS-CoV和MERS-CoV,迄今为止,其起源尚未被详细明确排除。在没有任何适当测量的情况下,COVID-19总体上显示出指数繁殖率,潜伏期接近14天。COVID-19的临床表现和大流行传播与早期SARS流行非常相似。SARS-CoV-2的发生;2019年底在中国被暂时称为新型冠状病毒2019或2019- ncov (COVID-19),已引起全球传播,是一个全球性的公共卫生问题。2020年1月底,世界卫生组织将COVID-19描述为第六次国际突发公共卫生事件。SARS-CoV-2类似于蝙蝠源性急性呼吸综合征、蝙蝠- sl - covzc45和蝙蝠- sl - covzxc21的严重冠状病毒。传播主要是通过飞沫或直接接触或粪便进行人际传播,而感染的潜伏期似乎长达14天,繁殖率为2.24-3.58。在sars - cov -2引起的肺炎患者中,发热是最突出的症状,其次是咳嗽。目前,阻止SARS-CoV-2的快速传播是卫生保健管理的首要干预措施。然而,卫生当局应继续密切监测这一情况。
{"title":"COVID-19: ACE-2 Receptor, TMPRSS2, Cathepsin-L/B and CD-147 Receptor","authors":"S. Bittmann","doi":"10.37191/mapsci-2582-385x-2(3)-031","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(3)-031","url":null,"abstract":"COVID-19 shows an extremely rapid spreading pattern, classified as SARS-CoV-2, has become a worldwide health problem. Relating to biological characteristics of SARS-CoV-2, the new viral agent was comprehensively summarized in order to optimize the date research on this novel disease and make adequate therapeutic decisions. The structure of COVID-19 virus is partially similar to SARS-CoV and MERS-CoV and to date, the origin is not clearly ruled out in detail. COVID-19 in general shows, without any adequate measurement, an exponential reproductive rate, an incubation of nearly 14 days. The clinical appearance and the pandemic spread of COVID-19 were very similar to earlier SARS epidemics. The occurrence of SARS-CoV-2; previously provisionally referred to as novel coronavirus 2019 or 2019-nCoV (COVID-19) in China in late 2019, has induced a global spreading and is a worldwide public health problem. At the end of January 2020, the World Health Organization described COVID-19 as the sixth international public health emergency. SARS-CoV-2 is similar to severe corona viruses similar to acute respiratory syndrome of bat origin, bat-SL-CoVZC45 and bat-SL-CoVZXC21. The transmission is based on by human-to-human transmission via droplets or direct contact or stool, whereas the infection seems to have an incubation period of up to 14 days and a reproduction rate of 2.24-3.58. In patients with SARS-CoV-2-induced pneumonia, fever was the prominent symptom in these patients followed by cough. Currently, stopping the rapid spreading of SARS-CoV-2 is the primary intervention in health care management. However, health authorities should continue to monitor the situation closely.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129643163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
COVID-19 Cure through Stem Cells 通过干细胞治愈COVID-19
Pub Date : 2020-05-05 DOI: 10.37191/mapsci-2582-385x-2(3)-034
Prithiv K R Kumar
Stem cells are the ultimate solution to treat any diseases. They help in giving solutions to the most deadly disease. The focus is on respiratory system because COVID-19 attracts that region, hence mesenchymal stem cells(MSC) is proposed to treat the disease. Clinical trials have already begun suggesting these therapeutics. They most probably will be helpful in preventing severe acute respiratory infection. A certain population of cells will get accumulated in the lungs after stem cell regeneration, to protect epithelial cells in the alveoli, cleanse the pulmonary artery and cure dysfunction in the lungs. In this review a new approach using mesenchymal stem cells has been taken into consideration for COVID cure. Currently, there seems little approach on basis of clinical trial on COVID patients. Stem cell therapy should show safe and highly effective method to cure COVID.
干细胞是治疗任何疾病的终极解决方案。他们帮助解决最致命的疾病。重点是呼吸系统,因为COVID-19吸引了该区域,因此建议使用间充质干细胞(MSC)治疗该疾病。临床试验已经开始提出这些治疗方法。它们很可能有助于预防严重的急性呼吸道感染。干细胞再生后会在肺内积累一定数量的细胞,起到保护肺泡上皮细胞、清洁肺动脉、治疗肺功能障碍的作用。在这篇综述中,我们考虑了一种利用间充质干细胞治疗COVID的新方法。目前,在新冠肺炎患者的临床试验基础上,似乎没有什么方法。干细胞治疗应该是安全有效的治疗方法。
{"title":"COVID-19 Cure through Stem Cells","authors":"Prithiv K R Kumar","doi":"10.37191/mapsci-2582-385x-2(3)-034","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(3)-034","url":null,"abstract":"Stem cells are the ultimate solution to treat any diseases. They help in giving solutions to the most deadly disease. The focus is on respiratory system because COVID-19 attracts that region, hence mesenchymal stem cells(MSC) is proposed to treat the disease. Clinical trials have already begun suggesting these therapeutics. They most probably will be helpful in preventing severe acute respiratory infection. A certain population of cells will get accumulated in the lungs after stem cell regeneration, to protect epithelial cells in the alveoli, cleanse the pulmonary artery and cure dysfunction in the lungs. In this review a new approach using mesenchymal stem cells has been taken into consideration for COVID cure. Currently, there seems little approach on basis of clinical trial on COVID patients. Stem cell therapy should show safe and highly effective method to cure COVID.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122730326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Fast Food Consumption among Teenagers Aged Between (13 To 25) Years Old and Their Effect on Health in Derna-Libya 利比亚13 - 25岁青少年的快餐消费及其对健康的影响
Pub Date : 2019-10-24 DOI: 10.37191/mapsci-2582-385x-1(1)-005
S. Eljamay
Background: Junk foods are rich in calories, salt and fats. Excess consumption of junk foods would lead rise to wide variety of health disorders.Objective: the purpose of this study is to find out about the fast food consumption of adolescent in age between 13-25 years old in Derna city and their effect on healthMethods: the sample of this research included 100 adolescents from both sexes, a descriptive cross-sectional study of teenagers was conducted. The questionnaire was divided into two part: first part related to socio-demographic information and part two related to junk food pattern and influencing factors of junk food consumption and their effect on health. Data were analyzed using SPSS version 24. A value of P < 0.05 was interpreted as statistically significant. Results: The findings revealed that more girls (67.0%) consumed fast food than boys and approximately half (49.0%) of Participants were consumed fast food as an alternative to main meal and more than half of participants (63.0%) were consume soft drink every day, furthermore greater proportion of participants (42.0%) had urinary tract infection and that may related to chips and soft drink were the most attractive food items among Participants.Conclusion: adolescent consumed a greater amount of junk food which led to a majority of ill effects later on. It is recommended that the schools and community conduct and implement awareness programmers on fast food consumption and its ill effects.
背景:垃圾食品富含卡路里、盐和脂肪。过量食用垃圾食品会导致各种各样的健康问题。目的:本研究的目的是了解德尔那市13-25岁青少年的快餐消费情况及其对健康的影响。方法:本研究的样本包括100名男女青少年,对青少年进行描述性横断面研究。问卷分为两部分,第一部分是社会人口统计信息,第二部分是垃圾食品消费模式、影响因素及其对健康的影响。数据采用SPSS version 24进行分析。P < 0.05为差异有统计学意义。结果:调查结果显示,女生(67.0%)比男生多吃快餐,约有一半(49.0%)的参与者以快餐代替正餐,超过一半(63.0%)的参与者每天饮用软饮料,此外,更大比例(42.0%)的参与者有尿路感染,这可能与薯片和软饮料是参与者中最具吸引力的食物有关。结论:青少年消费了大量的垃圾食品,这导致了后来的大多数不良影响。建议学校和社区开展和实施关于快餐消费及其不良影响的意识项目。
{"title":"Fast Food Consumption among Teenagers Aged Between (13 To 25) Years Old and Their Effect on Health in Derna-Libya","authors":"S. Eljamay","doi":"10.37191/mapsci-2582-385x-1(1)-005","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(1)-005","url":null,"abstract":"Background: Junk foods are rich in calories, salt and fats. Excess consumption of junk foods would lead rise to wide variety of health disorders.\u0000\u0000Objective: the purpose of this study is to find out about the fast food consumption of adolescent in age between 13-25 years old in Derna city and their effect on health\u0000\u0000Methods: the sample of this research included 100 adolescents from both sexes, a descriptive cross-sectional study of teenagers was conducted. The questionnaire was divided into two part: first part related to socio-demographic information and part two related to junk food pattern and influencing factors of junk food consumption and their effect on health. Data were analyzed using SPSS version 24. A value of P < 0.05 was interpreted as statistically significant. Results: The findings revealed that more girls (67.0%) consumed fast food than boys and approximately half (49.0%) of Participants were consumed fast food as an alternative to main meal and more than half of participants (63.0%) were consume soft drink every day, furthermore greater proportion of participants (42.0%) had urinary tract infection and that may related to chips and soft drink were the most attractive food items among Participants.\u0000\u0000Conclusion: adolescent consumed a greater amount of junk food which led to a majority of ill effects later on. It is recommended that the schools and community conduct and implement awareness programmers on fast food consumption and its ill effects.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115620426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
期刊
Journal of Regenerative Biology and Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1