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Anesthetic challenges in a case of Sheehan's syndrome posted for open reduction and internal fixation and nailing following fracture femur 麻醉挑战在希恩综合征的情况下公布开放复位和内固定和钉后股骨骨折
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_78_21
Abinaya Ramachandran, Nagalakshmi Palanisamy, P. Johny, R. Ranjan
Sheehan's syndrome is postpartum hypopituitarism caused by necrosis of the pituitary gland due to severe hypotension or shock caused by massive hemorrhage during or after delivery. Patients with Sheehan's syndrome have varying degrees of pituitary hormone deficiency. There is increased sensitivity to barbiturates and opiates in patients with Sheehan's syndrome. They are more prone to hypotension, hypoxia, and hypothermia which must be addressed intraoperatively. Herein, we report successful anesthetic management of a patient with Sheehan's syndrome with distal third femoral shaft fracture for fixation who had numerous hormonal and electrolyte abnormalities. This case report emphasizes the importance of meticulous preanesthetic assessment, optimization, and perioperative management of patients with Sheehan's syndrome for successful management of the case.
希恩氏综合征是一种产后垂体功能减退症,由分娩时或分娩后大出血引起的严重低血压或休克导致垂体坏死引起。希恩综合征患者有不同程度的垂体激素缺乏症。希恩氏综合征患者对巴比妥类药物和阿片类药物的敏感性增加。他们更容易出现低血压、缺氧和体温过低,这些都必须在术中处理。在此,我们报告一例伴有股骨第三骨干远端骨折的Sheehan综合征患者的成功麻醉治疗,该患者有大量激素和电解质异常。本病例报告强调了细致的麻醉前评估、优化和围手术期管理对成功治疗希恩综合征患者的重要性。
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引用次数: 0
Erroneous display of inhalational agent..! 吸入剂显示错误…!
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_65_21
Anamika Agnihotri, Minal Mali, S. Valasareddy
A well-equipped anesthesia workstation is a boon for better anesthesia practice. Advancement in technical aspects such as respiratory gas analysis made perioperative care better and safer. Any kind of equipment troubleshoot can contribute to morbidity and mortality; however, the magnitude of these is not established.
一个装备精良的麻醉工作站有利于更好的麻醉实践。呼吸气体分析等技术方面的进步使围手术期护理更好、更安全。任何类型的设备故障都可能导致发病率和死亡率;然而,这些影响的大小尚未确定。
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引用次数: 0
A randomized, open-label, multicentered parallel-group clinical study to evaluate the efficacy and safety of Joint Core™ compared to Jointace DN™ in osteoarthritis patients 一项随机、开放标签、多中心平行组临床研究,评估Joint Core™与Jointace DN™在骨关节炎患者中的疗效和安全性
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_21_22
R. Kannan, S. Bakthavatchalam., S. Murugesan, B. Kumar, Bijoy Deb, Chandramohan Marimuthu, Priya M Rajendran
Background: Osteoarthritis (OA) is one of the most common musculoskeletal diseases worldwide, with pain, joint stiffness, fatigue associated with disability, and loss of physical activity. There is a need for an effective and safer alternative medication for the management of OA knee in elderly patients as the current medications possess severe risks to the patient compromising the quality of life. Methodology: The study design and setting were phase 3, randomized, open-label, multicentered, active-controlled parallel-group interventional trial conducted at secondary care centers in Puducherry. Fifty patients (50) patients with OA knee were enrolled as per study criteria and randomized to receive Joint Core™ and Jointace DN™ for 12 weeks. The outcomes were assessed using various pain scales and subscales, Short-Form Health-12 (SF-12) questionnaire, and inflammatory markers. The data obtained at baseline and weeks 4, 8, and 12 were compared and statistically analyzed. Results: Joint Core™ showed continuous reduction in the Visual Analog Scale pain scores at 4, 8, and 12 weeks and improvement in Western Ontario and McMaster Universities OA Index subscale and pain global assessment scales and good response rate in the Outcome Measures for Rheumatology Committee and OA Research Society International Standing Committee for Clinical Trials Response Criteria Initiative scores proving it to be efficacious in the treatment of OA knee compared to Jointace DN™. The safety assessed showed that Joint Core™ produces minimal gastrointestinal side effects and does not affect any organs as assessed by the laboratory parameters. Conclusion: Joint Core™ is effective and safe in the treatment of OA knee when compared to its comparator Jointace DN™. Joint Core™ can be an alternative treatment option in the patients with OA knee who are intolerant to diacerein-based combinations available to treat OA.
背景:骨关节炎(OA)是世界范围内最常见的肌肉骨骼疾病之一,与疼痛、关节僵硬、残疾相关的疲劳和身体活动的减少有关。由于目前的药物对患者的生活质量有严重的危害,因此需要一种有效且更安全的替代药物来治疗老年OA膝关节。方法:研究设计和设置为在Puducherry二级护理中心进行的随机、开放标签、多中心、主动对照平行组介入试验的3期。按照研究标准入组50例OA膝关节患者,随机接受Joint Core™和Jointace DN™治疗12周。结果评估使用各种疼痛量表和亚量表,健康-12 (SF-12)问卷和炎症标志物。在基线和第4、8、12周获得的数据进行比较和统计分析。结果:与Jointace DN™相比,Joint Core™在4、8和12周的视觉模拟量表疼痛评分持续下降,在Western Ontario和McMaster university OA Index亚量表和疼痛总体评估量表中有所改善,并且在风湿病委员会结局测量指标和OA研究学会国际临床试验反应标准倡议评分中有良好的缓解率,证明它在治疗OA膝关节方面比Jointace DN™有效。安全性评估显示,Joint Core™产生最小的胃肠道副作用,并且根据实验室参数评估不影响任何器官。结论:与比较产品Jointace DN™相比,Joint Core™治疗OA膝关节有效且安全。关节核心™可以作为OA膝关节患者的替代治疗选择,这些患者对现有的以糖尿素为基础的联合治疗OA不耐受。
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引用次数: 0
The prophylactic antimalarial activity of Combretum nigricans hydromethanol crude extract in mice 黑麦草氢甲醇粗提物对小鼠的预防抗疟作用
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_18_21
Chinedu Enegide, C. Ofili, U. Agatemor, D. Jacob
Background: Malaria has maintained its historic threat to global health, with nearly 40% of the world's population being at risk of its mayhem. The increasing cases of resistance by Plasmodium parasite to the currently available antimalarial agents have led to increased scientific screening of medicinal plants for the possible development of newer agents, both for treatment and chemoprophylaxis against malaria. This study was designed to evaluate the prophylactic antimalarial activity of Combretum nigricans hydromethanol crude leaf extract in mice. Materials and Methods: The prophylactic activity of C. nigricans hydromethanol crude leaf extract was evaluated using the method illustrated by Peters. Six groups containing five mice each were used for the study. Group 1 (control) received distilled water 10 ml/kg b.w. p.o., Groups 2–4 were treated with 200, 400, and 800 mg extract/kg b.w. p.o., respectively, Group 5 mice were treated with chloroquine 10 mg/kg b.w. p.o., whereas Group 6 mice were treated with artesunate 10 mg/kg b.w. p.o. Results: The result showed significant (P < 0.05) chemoprophylactic activity in all treated groups compared with the control group. The chemoprophylactic activity of the extract was 55.4, 61.6, and 79.5% for 200, 400, and 800 mg/kg, respectively. A dose-related increase in mice body weight was also observed in the extract-treated groups. Phytochemical screening of the extract revealed the presence of several important active principles, including alkaloids, saponins, and flavonoids. Conclusion: The present study revealed that C. nigricans hydromethanol crude leaf extract possesses significant chemoprophylactic activity against malaria.
背景:疟疾一直对全球健康构成历史性威胁,世界上近40%的人口面临其危害的风险。疟原虫对目前可用的抗疟疾药物产生耐药性的病例越来越多,这导致对药用植物的科学筛选越来越多,以便可能开发用于治疗和化学预防疟疾的新药物。本研究旨在评价黑藤氢甲醇粗叶提取物对小鼠的预防抗疟作用。材料与方法:采用Peters方法对黑曲霉氢甲醇粗叶提取物的预防作用进行了评价。研究共分为六组,每组5只。1组(对照组)分别给予蒸馏水10 ml/kg b.w. p.o, 2 ~ 4组分别给予提取物200、400、800 mg/kg b.w. p.o, 5组给予氯喹10 mg/kg b.w. p.o, 6组给予青蒿琥酯10 mg/kg b.w. p.o。结果:与对照组相比,各处理组均有显著(P < 0.05)的化学预防活性。200、400和800 mg/kg时,其化学预防活性分别为55.4、61.6和79.5%。在提取物处理组中也观察到小鼠体重的剂量相关增加。植物化学筛选发现了几种重要的活性成分,包括生物碱、皂苷和黄酮类化合物。结论:黑曲霉氢甲醇粗叶提取物对疟疾具有明显的化学预防作用。
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引用次数: 0
The role of copeptin in the prognosis of ischemic stroke copeptin在缺血性卒中预后中的作用
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_91_21
J. Rissardo, Ana Letícia Fornari Caprara
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引用次数: 0
A case of enteric fever complicated by hemophagocytic lymphohistiocytosis probably induced by ChAdOx1 nCoV-19 COVID-19 vaccine 可能由ChAdOx1 nCoV-19 -19疫苗引起的肠热合并噬血细胞性淋巴组织细胞增多症1例
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_94_21
M. Cherian, Siddhant Thampi
Although enteric fever is a relatively common disease in countries mainly belonging to South Asia (incidence of around 100/100,000 persons per year) where there is poor hygiene, its complications in the form of hemophagocytic lymphohistiocytosis (HLH) are rare but have been documented before. Here, we present the case of a 19-year-old boy diagnosed with enteric fever with secondary HLH possibly induced by the COVID-19 vaccine (COVISHIELD ChAdOx1 nCoV-19 coronavirus vaccine [Recombinant]). Although there is no proof that the vaccine could have induced secondary HLH, its possibility cannot be ruled out simultaneously. Early identification and diagnosis of HLH are of extreme importance. If not treated correctly, mortality can reach up to 40%. In this article, we would like to press upon the clinical presentation, diagnosis, and management of such a case and the possibility of this presentation being induced by the COVID-19 vaccine.
虽然在卫生条件差的南亚国家,肠热是一种相对常见的疾病(每年发病率约为100/100,000人),但其以噬血细胞性淋巴组织细胞增多症(HLH)形式出现的并发症很少见,但以前已有记录。在这里,我们报告了一例19岁的男孩被诊断为肠热并继发性HLH,可能是由COVID-19疫苗(COVISHIELD ChAdOx1 nCoV-19冠状病毒疫苗[重组])引起的。虽然没有证据表明该疫苗可能诱发继发性HLH,但不能同时排除其可能性。HLH的早期识别和诊断非常重要。如果治疗不当,死亡率可高达40%。本文就该病例的临床表现、诊断和处理,以及COVID-19疫苗诱发的可能性进行探讨。
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引用次数: 0
Vitamin D levels among adults in a tertiary care hospital in Wayanad Wayanad三级保健医院成人的维生素D水平
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_81_21
Aiswarya Raj, Shreya Cherian, Shuba Srinivasan
Background: Vitamin D insufficiency affects nearly 50% of the population worldwide. Inadequate serum Vitamin D levels are associated with multiple conditions such as secondary hyperparathyroidism and increased fracture risk. Multiple studies carried out also showed a correlation between Vitamin D deficiency and occurrence of diabetes and hypertension (HTN) in these deficient individuals. This study aimed to determine the serum levels of Vitamin D among patients frequenting a tertiary care hospital in Wayanad and the associations with sunlight exposure, gender, dietary factors, and diabetes and HTN. Settings and Design: Cross-sectional study. Materials and Methods: Hundred patients were randomly selected from the outpatient department over 6 months and asked to fill up a questionnaire. Vitamin D analysis was done by Elecsys Vitamin D total assay. Statistical analysis used was IBM SPSS statistics for Windows, version 20.0: Association between continuous data was determined using t-test/Mann–Whitney test depending on normality of data and association between categorical variables was determined using Pearson's Chi-square test. Results: Fifty-seven percentage of patients had Vitamin D deficiency. Significantly lower values of Vitamin D were seen among women. Conclusions: The median Vitamin D levels in men were 22.785 ng/ml and 17.81 ng/ml in women. No association was established between >1 h of daily sunlight exposure, the prevalence of diabetes and HTN, and daily consumption of dairy products and Vitamin D deficiency.
背景:全球近50%的人口受到维生素D缺乏的影响。血清维生素D水平不足与继发性甲状旁腺功能亢进和骨折风险增加等多种疾病有关。多项研究还表明,维生素D缺乏与这些缺乏维生素D的人患糖尿病和高血压(HTN)之间存在相关性。本研究旨在确定在Wayanad三级医院就诊的患者血清中维生素D的水平及其与阳光照射、性别、饮食因素、糖尿病和HTN的关系。设置与设计:横断面研究。材料与方法:在门诊随机抽取100例6个月以上的患者填写问卷。维生素D分析采用Elecsys维生素D总含量测定法。统计分析采用IBM SPSS for Windows, version 20.0统计数据:根据数据的正态性,使用t检验/ Mann-Whitney检验确定连续数据之间的相关性,使用Pearson卡方检验确定分类变量之间的相关性。结果:57%的患者缺乏维生素D。女性的维生素D含量明显较低。结论:男性维生素D水平中位数为22.785 ng/ml,女性为17.81 ng/ml。每日日照时间>1小时、糖尿病和HTN患病率、每日乳制品消费量和维生素D缺乏症之间没有关联。
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引用次数: 0
Assessment of risk-taking behavior, leadership effectiveness, intelligence, ability to handle stress in college-going students, and effect of self-control on these parameters 大学生的冒险行为、领导效能、智力、压力处理能力的评估,以及自我控制对这些参数的影响
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_92_21
Mohita Singh, S. Sachdev, Amrita Singh
Background: Human intelligence is the intellectual prowess of humans, which is marked by high cognition, motivation, and self-awareness. Leadership is the art of motivating a group of people to achieve common goals. Risk-taking is conscious or nonconscious controlled behavior with perceived uncertainty about its outcome. The present study was designed to assess the risk-taking ability of an individual that is required to be a good leader along with intelligence, ability to handle stress, and the effect of self-control on these parameters. Materials and Methods: The study was performed in two phases. In the first phase, the subjects were asked to fill risk-taking questionnaire, and their leadership effectiveness and intelligence levels were assessed. Their basal level of stress parameters and Stroop test were assessed. A stressor was introduced and stress parameters, Stroop test were again assessed. In the second phase of the study, the subjects were asked to practice moderate-intensity physical activity for 15 days and its effect was seen on all the above parameters. Results: Statistically significant and nonsignificant differences were obtained on comparison between baseline and poststress values; and also between baseline and postexercise values in all the three groups namely high-risk takers, moderate risk-takers and nonrisk takers at different level of significance. Comparison between first phase and second phase of the study yielded significant and non-significant results. Conclusion: Self-control improves leadership effectiveness. Exercise helps reduce stress response that aids in better decision-making quality required for being a leader.
背景:人类智力是人类的智力能力,其特征是高度的认知、动机和自我意识。领导是激励一群人实现共同目标的艺术。冒险是一种有意识或无意识的控制行为,对其结果有不确定性。本研究旨在评估一名优秀领导者所需要的个人冒险能力、智力、处理压力的能力以及自我控制对这些参数的影响。材料与方法:研究分两期进行。第一阶段,要求被试填写冒险行为问卷,评估其领导效能和智力水平。对其基础应力参数水平和Stroop试验进行评估。引入应力源,重新评估应力参数、Stroop试验。在研究的第二阶段,受试者被要求进行15天中等强度的体育活动,并观察其对上述所有参数的影响。结果:基线值与应激后值比较,差异均有统计学意义和无统计学意义;在基线值和运动后值之间在所有三组中即高危者,中等风险者和非风险者在不同的显著性水平上。第一阶段和第二阶段研究的比较得出了显著和非显著的结果。结论:自我控制能提高领导效能。锻炼有助于减少压力反应,有助于提高作为领导者所需的决策质量。
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引用次数: 0
Gender dysphoria in adults: Concept, critique, and controversies 成人性别焦虑:概念、批评和争议
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_33_22
A. Faheem, Ilambaridhi Balasubramanian, V. Menon
Gender dysphoria (GD) is a condition where one feels distressed about one's assigned gender at birth. The construct has undergone successive revisions in understanding and terminology in contemporary classificatory systems. Currently, the terms “GD” and “gender incongruence” are used in the Diagnostic and Statistical Manual of Mental Disorders-5 and International Classification of Diseases-11, respectively. However, there continues to be a lack of clarity on terminologies used in describing related concepts. Sex is an inflexible categorical concept, whereas gender is a social construct. It is vital to understand and distinguish between sexual orientation and gender identity. Clarity in understanding and usage of these and other related terms in the field is central to addressing the issue of stigma faced by the members of the lesbian, gay, bisexual, transgender, queer, intersex, asexual+ (LGBTQIA+) community, an umbrella term used to denote individuals with nonconformative gender identity and orientation. Several clinical and ethical issues exist with diagnosing and managing GD such as optimal treatment of minors, fertility after gender affirming treatments, and dissatisfaction following gender reassignment. To clarify these issues and facilitate access to care for LGBTQIA+ individuals, the GD category has been retained in the classificatory systems despite activists calling for dropping the term from diagnostic manuals to minimize associated stigma. Other controversies in the area include inclusion of childhood GD diagnosis on the grounds of uncertainty of longitudinal trajectory of the clinical phenomenon and use of nonevidence-based, potentially harmful, treatments such as “conversion therapies.” There is a need to sensitize clinicians about these issues and mainstream them in the assessment and management of GD. Such an approach would aid development of culturally sensitive and evidence-based treatments for gender variance.
性别焦虑症(GD)是一种对出生时的性别感到苦恼的症状。在当代的分类系统中,这一结构在理解和术语方面经历了不断的修订。目前,术语“性别失调”和“性别不一致”分别在《精神疾病诊断与统计手册-5》和《国际疾病分类-11》中使用。然而,在描述相关概念时使用的术语仍然不够清晰。性是一个僵化的分类概念,而社会性别是一种社会建构。理解和区分性取向和性别认同是至关重要的。清晰地理解和使用这些术语以及该领域的其他相关术语,对于解决女同性恋、男同性恋、双性恋、跨性别者、酷儿、双性恋、无性恋+ (LGBTQIA+)群体成员所面临的耻辱问题至关重要。LGBTQIA+是一个总称,用于指代具有不符合常规性别认同和取向的个体。在诊断和管理性别焦虑方面存在一些临床和伦理问题,如未成年人的最佳治疗、性别确认治疗后的生育能力以及性别重新分配后的不满。为了澄清这些问题并方便LGBTQIA+个体获得护理,尽管活动人士呼吁从诊断手册中删除GD这一术语,以尽量减少相关的污名,但GD类别仍保留在分类系统中。该领域的其他争议包括,基于临床现象纵向轨迹的不确定性,以及使用非循证的、潜在有害的治疗方法,如“转化疗法”,将儿童性别焦虑诊断纳入其中。有必要提高临床医生对这些问题的敏感性,并将其纳入GD的评估和管理的主流。这种方法将有助于开发对性别差异具有文化敏感性和基于证据的治疗方法。
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引用次数: 1
Knowledge, attitude, and Practices of telemedicine among the health-care practitioners during COVID pandemic: A cross-sectional study COVID大流行期间医护人员远程医疗的知识、态度和实践:一项横断面研究
Pub Date : 2022-01-01 DOI: 10.4103/jcrsm.jcrsm_59_21
Mahalaxmi S. Petimani, N. Bhat, P. Preethishree, Prabhakar Adake
Introduction: COVID pandemic created a difficult situation for the medical fraternity. Many health-care practitioners achieved their work through telemedicine. For delivering better patient care, especially during the pandemic, the present study was conducted to assess the Knowledge, Attitude, and Practices (KAP) of telemedicine among healthcare practitioners of our institution. Materials and Methods: A prevalidated questionnaire form containing 13 questions on KAP of telemedicine was circulated to health-care practitioners through Google Form by snowball technique. A total of 96 responses were collected. Descriptive statistical method was applied and results are expressed in percentages. Results: Out of 96 responses, 61 (63.5%) were from men and 35 (36.5%) from women. About 63.5% of health-care practitioners were aware of the term telemedicine, 22.9% were aware but not practising, and 13.5% were aware and currently practising telemedicine. Regarding the mode of telemedicine, 42.7% preferred video calling (Skype/hangout/WhatsApp), followed by 27.1% personalized website (HODO/Healzapp), 17.7% by text message (SMS/Email/Fax), and 12.5% for an audio phone call. With respect to taking consent, 59.4% expressed that consent is required and 40.6% expressed that consent is implied when the patient initiates the call. Regarding challenges in telemedicine, 83.3% expressed that clinical examinations cannot be done, 76% for connectivity issues, 55.2% worried about patient safety, and 54.2% for medico-legal issues. 53.1% of health-care practitioners would like to charge the same fees for telemedicine, followed by 27.1% lower fees, 12.5% no fees, and 7.3% would like to charge higher fees than routine. Conclusion: Telemedicine is essential for patient care, especially during a pandemic. Hence, National Medical Commission should incorporate telemedicine modules in the undergraduate curriculum for better patient care.
导读:新冠疫情给医学界带来了困难。许多保健从业人员通过远程医疗完成了工作。为了提供更好的患者护理,特别是在大流行期间,本研究旨在评估我院医护人员远程医疗的知识、态度和实践(KAP)。材料与方法:采用滚雪球技术,通过Google form向卫生保健从业人员发放一份包含13个远程医疗KAP问题的预验证问卷。共收集了96份回复。采用描述性统计方法,结果以百分数表示。结果:96份问卷中,男性61份(63.5%),女性35份(36.5%)。约63.5%的卫生保健从业人员知道远程医疗一词,22.9%知道但不执业,13.5%知道并正在执业远程医疗。在远程医疗的方式上,42.7%的人选择视频通话(Skype/hangout/WhatsApp), 27.1%的人选择个性化网站(HODO/Healzapp), 17.7%的人选择短信(SMS/Email/Fax), 12.5%的人选择语音通话。至于取得同意,59.4%表示必须征得同意,40.6%表示在病人主动致电时已隐含征得同意。对于远程医疗的挑战,83.3%的人表示无法进行临床检查,76%的人担心连接问题,55.2%的人担心患者安全,54.2%的人担心医疗法律问题。53.1%的医疗从业者希望远程医疗收取相同的费用,其次是低收费27.1%,不收费12.5%,7.3%希望收取高于常规的费用。结论:远程医疗对患者护理至关重要,特别是在大流行期间。因此,国家医学委员会应将远程医疗模块纳入本科课程,以改善患者护理。
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引用次数: 1
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Journal of Current Research in Scientific Medicine
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