G. Iviglia, C. Cassinelli, José Luis Peris Serra, Víctor Javier Primo Capella, M. Morra
Replacement of bone loss or reconstruction of bone defect is still a clinical challenge. Different type of bone substitutes are used in clinical practice for treating bone defect caused by trauma, osteoporosis or dental pathology such as periodontitis [1,2]. The mode of action of the biomaterials available on the market mainly relies on mechanical support and is thus limited to providing a functional scaffold for cell adhesion. Synthetic bone fillers, mostly based on calcium phosphate materials, have been widely used due to their good reproducibility, biocompatibility, non-immunogenicity, and also because they offer the opportunity of advanced material engineering [3,4]. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) are widely used in bone tissue engineering as bone filler particles [5,6].
{"title":"Evaluation of Bone Regeneration Efficacy in a Rabbit Model of Femoral Condyles Defect by Polyphenols-Containing Bone Filler","authors":"G. Iviglia, C. Cassinelli, José Luis Peris Serra, Víctor Javier Primo Capella, M. Morra","doi":"10.31038/jdmr.2020334","DOIUrl":"https://doi.org/10.31038/jdmr.2020334","url":null,"abstract":"Replacement of bone loss or reconstruction of bone defect is still a clinical challenge. Different type of bone substitutes are used in clinical practice for treating bone defect caused by trauma, osteoporosis or dental pathology such as periodontitis [1,2]. The mode of action of the biomaterials available on the market mainly relies on mechanical support and is thus limited to providing a functional scaffold for cell adhesion. Synthetic bone fillers, mostly based on calcium phosphate materials, have been widely used due to their good reproducibility, biocompatibility, non-immunogenicity, and also because they offer the opportunity of advanced material engineering [3,4]. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) are widely used in bone tissue engineering as bone filler particles [5,6].","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120954523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Treatment of AOB should not be viewed as simple as placing a tongue crib for growing individuals, and treating adult patients with posterior segments intrusion or orthognathic surgery. Tongue size & position, incisal show at rest and on smiling, mandibular plane steepness and lip competence should all be closely monitored before planning what should be done. There is still a need for a detailed systematic analysis of all these components and relating these findings to the possible treatment options to serve as a guide for orthodontists in dealing with such difficult cases. This is currently our area of interest and we are working as a team to establish a schematic approach, aiming to specifically recognize the exact components of AOB malocclusion and target our treatment accordingly.
{"title":"Letter to the Editor - Open Bite Malocclusion: Analysis of the Underlying Components","authors":"Heba E Akl, Amira A. Aboalnaga, Y. Mostafa","doi":"10.31038/jdmr.2020333","DOIUrl":"https://doi.org/10.31038/jdmr.2020333","url":null,"abstract":"Treatment of AOB should not be viewed as simple as placing a tongue crib for growing individuals, and treating adult patients with posterior segments intrusion or orthognathic surgery. Tongue size & position, incisal show at rest and on smiling, mandibular plane steepness and lip competence should all be closely monitored before planning what should be done. There is still a need for a detailed systematic analysis of all these components and relating these findings to the possible treatment options to serve as a guide for orthodontists in dealing with such difficult cases. This is currently our area of interest and we are working as a team to establish a schematic approach, aiming to specifically recognize the exact components of AOB malocclusion and target our treatment accordingly.","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123951171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reem AlYamoor, S. Stefanescu, Haider Al-Saffar, M. Chirila
Endodontic treatments involve accessing a sterile or non-sterile pulp chamber and root canal content, following an inflammation of the pulp or bacterial colonization of the pulp chamber and root canals, as a septic complication of decay. For this purpose, stainless steel instruments were developed in the last century and Ni-Ti files more recently, serving for different purposes during different procedures and manoeuvres having the unique goal to clean and seal the root canal respecting the biologic and mechanical principles stated by Schilder [1]. Newer (Ni-Ti) files not only increased the speed of the treatment but also managed to assure a proper shape of the canal preparation and subsequently, of the canal filling. Being so useful, reliable, resistant, and ultimately, not cheap, the initially single-use instruments got to be reused by a wide number of practitioners for at least 5 times, with great success, being assured by the manufacturers that both files and the tooth are safe. There are reports of file reuse on 12 [2] or 24 [3] extracted roots having medium curvature.
{"title":"A Critical Evaluation of the Single-Use Policy of Endodontic Instruments","authors":"Reem AlYamoor, S. Stefanescu, Haider Al-Saffar, M. Chirila","doi":"10.31038/jdmr.2020310","DOIUrl":"https://doi.org/10.31038/jdmr.2020310","url":null,"abstract":"Endodontic treatments involve accessing a sterile or non-sterile pulp chamber and root canal content, following an inflammation of the pulp or bacterial colonization of the pulp chamber and root canals, as a septic complication of decay. For this purpose, stainless steel instruments were developed in the last century and Ni-Ti files more recently, serving for different purposes during different procedures and manoeuvres having the unique goal to clean and seal the root canal respecting the biologic and mechanical principles stated by Schilder [1]. Newer (Ni-Ti) files not only increased the speed of the treatment but also managed to assure a proper shape of the canal preparation and subsequently, of the canal filling. Being so useful, reliable, resistant, and ultimately, not cheap, the initially single-use instruments got to be reused by a wide number of practitioners for at least 5 times, with great success, being assured by the manufacturers that both files and the tooth are safe. There are reports of file reuse on 12 [2] or 24 [3] extracted roots having medium curvature.","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130266634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Al-Kattan, Eman Allam, M. Qadoumi, Nouf Alshibani
Mouthwashes are medicated solutions used as a supplement oral hygiene measure. Several oral conditions may require the use of a mouthwash ranging from halitosis, gingivitis and other periodontal diseases to treatment of ulcerative and infectious lesions and oral mucositis. Its ease of use in addition to the antibacterial effectiveness made mouthwashes a valuable preventive and therapeutic practice especially for periodontal diseases. A mouthwash may be recommended as an antimicrobial, anti-inflammatory, analgesic, deodorant, or astringent agent [1-3].
{"title":"Mouthwash Use and Associated Factors among Saudi Adults: A Cross-sectional Study","authors":"R. Al-Kattan, Eman Allam, M. Qadoumi, Nouf Alshibani","doi":"10.31038/jdmr.2020323","DOIUrl":"https://doi.org/10.31038/jdmr.2020323","url":null,"abstract":"Mouthwashes are medicated solutions used as a supplement oral hygiene measure. Several oral conditions may require the use of a mouthwash ranging from halitosis, gingivitis and other periodontal diseases to treatment of ulcerative and infectious lesions and oral mucositis. Its ease of use in addition to the antibacterial effectiveness made mouthwashes a valuable preventive and therapeutic practice especially for periodontal diseases. A mouthwash may be recommended as an antimicrobial, anti-inflammatory, analgesic, deodorant, or astringent agent [1-3].","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131913945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In 10th March 2020, the whole world faces a globally dangerous random attack by specific, enveloped, nonsegmented, single-strand RNA viruses termed as Coronavirus [1,2]. The Challenge attack story started, in December 2019 when the World Health Organization) WHO( in China Wuhan state received information regarding some cases were detected of pneumonia of unknown aetiology [3] and extracting a novel coronavirus from lower respiratory tract sample of many cases. This novel beta coronavirus presently named 2019 novel coronavirus (2019-nCoV) [4].
{"title":"Corona Virus Transmission and Controls Challenge Mystery for Dentists (Systematic Review)","authors":"R. Al-Rawee, Mustafa Mohammed Saeed","doi":"10.31038/jdmr.2020322","DOIUrl":"https://doi.org/10.31038/jdmr.2020322","url":null,"abstract":"In 10th March 2020, the whole world faces a globally dangerous random attack by specific, enveloped, nonsegmented, single-strand RNA viruses termed as Coronavirus [1,2]. The Challenge attack story started, in December 2019 when the World Health Organization) WHO( in China Wuhan state received information regarding some cases were detected of pneumonia of unknown aetiology [3] and extracting a novel coronavirus from lower respiratory tract sample of many cases. This novel beta coronavirus presently named 2019 novel coronavirus (2019-nCoV) [4].","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125383716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samah Elsaid Mohammed El Behary, Ebtesam Abd ELKhalek El-Zefzaf, Sahar M. F. Ghoraba
Healthy oral mucosa is pink in color, but it can vary from light to dark pink depending on the thickness of epithelium, the amount of melanin and the number of erythrocytes present in the connective tissue vessels and their proximity to the surface. Gingival pigmentation is defined as color change of the gingiva from variable shades of pink to dark brown or black due to genetic factors which is the most important endogenous factor responsible for increased production of melanin by melanocytes, or pathological factors. Some other exogenous factors such as ultra violet radiation (UV), smoking and medications may also increase melanin synthesis [1]. Genetics Racial gingival pigmentation is a common esthetic concern, which is aggravated in patients with excessive gingival display and more common noticed in adults, the attached gingiva is the most common site of involvement in the anterior region of the maxilla and mandible followed by the buccal mucosa, lip corners, lip mucosa, dorsal and ventral surface of the tongue and rarely the floor of the mouth [2] Kauzman [3] were broadly classified the gingival pigmentation into: Research Article
{"title":"Low Level Diode Laser Therapy versus Surgical Abrasion in the Treatment of Gingival Racial Pigmentation – Clinical Study","authors":"Samah Elsaid Mohammed El Behary, Ebtesam Abd ELKhalek El-Zefzaf, Sahar M. F. Ghoraba","doi":"10.31038/jdmr.2020324","DOIUrl":"https://doi.org/10.31038/jdmr.2020324","url":null,"abstract":"Healthy oral mucosa is pink in color, but it can vary from light to dark pink depending on the thickness of epithelium, the amount of melanin and the number of erythrocytes present in the connective tissue vessels and their proximity to the surface. Gingival pigmentation is defined as color change of the gingiva from variable shades of pink to dark brown or black due to genetic factors which is the most important endogenous factor responsible for increased production of melanin by melanocytes, or pathological factors. Some other exogenous factors such as ultra violet radiation (UV), smoking and medications may also increase melanin synthesis [1]. Genetics Racial gingival pigmentation is a common esthetic concern, which is aggravated in patients with excessive gingival display and more common noticed in adults, the attached gingiva is the most common site of involvement in the anterior region of the maxilla and mandible followed by the buccal mucosa, lip corners, lip mucosa, dorsal and ventral surface of the tongue and rarely the floor of the mouth [2] Kauzman [3] were broadly classified the gingival pigmentation into: Research Article","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117079990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Stefanescu, Alexandru Buciu, Alexandru Branislav Cirin
Radon is a radioactive gas, generated by uranium deposits. It is emitted normally by rocks, earth’s crust, and it can delve inside the buildings through planking, wall cracks, or along the pipes [1]. It can be present not only in the air but also in soil and construction materials. In areas with high potential risk (i.e. uranium mines), radon’s air concentration can reach high values due to both soil and construction materials [2]. Recent researches showed that radon is the main source of population’s natural irradiation, contributing with approximately 57% to the effective annual radiation dose and it can rise, in certain areas, to a contribution of 95%, cases in which the exposure to natural radiation is 5-10 times higher than the medium exposure value of 2,2 mSv/year [2,3].
{"title":"Dental perspective on radioactive nuclides in humans living on the premisses of uranium mining facilities","authors":"S. Stefanescu, Alexandru Buciu, Alexandru Branislav Cirin","doi":"10.31038/jdmr.2020304","DOIUrl":"https://doi.org/10.31038/jdmr.2020304","url":null,"abstract":"Radon is a radioactive gas, generated by uranium deposits. It is emitted normally by rocks, earth’s crust, and it can delve inside the buildings through planking, wall cracks, or along the pipes [1]. It can be present not only in the air but also in soil and construction materials. In areas with high potential risk (i.e. uranium mines), radon’s air concentration can reach high values due to both soil and construction materials [2]. Recent researches showed that radon is the main source of population’s natural irradiation, contributing with approximately 57% to the effective annual radiation dose and it can rise, in certain areas, to a contribution of 95%, cases in which the exposure to natural radiation is 5-10 times higher than the medium exposure value of 2,2 mSv/year [2,3].","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129660981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
lower respiratory tract infection. All patients were initially diagnosed by RT-PCR from oro- or nasopharyngeal Abstract Objectives : To study if some antiseptic agent rinse can reduce the viral load of COVID-19 in the infected patients to minimize its virulence in respiratory tract, and therefore the contagious. Materials and Methods: To analyze of scientific articles published in the last months, about the use and effectivity of some mouthwash against COVID-19 and write an update. Rinses, as an adjunctive measure for containing the COVID-19 transmission, are important to keep in mind, but there are very few articles on COVID-19 that cover mouthwashes. Conclusions: A concentration of 1% - 1.5% hydrogen peroxide solution or 1% - 0.2% povidone-iodine seem to be an effective mouthwash to reduce the viral load in oral cavity of COVID-19. Clinical Relevance: Due to COVID-19 pandemic, we are suffering, and growing information about this virus, questions about which antiseptic rinse to use to decrease the viral load is essential.
{"title":"What is the most effective mouthwash in patients infected with covid-19 to minimize possible transmission by saliva? Update.","authors":"J. Roca","doi":"10.31038/jdmr.2020315","DOIUrl":"https://doi.org/10.31038/jdmr.2020315","url":null,"abstract":"lower respiratory tract infection. All patients were initially diagnosed by RT-PCR from oro- or nasopharyngeal Abstract Objectives : To study if some antiseptic agent rinse can reduce the viral load of COVID-19 in the infected patients to minimize its virulence in respiratory tract, and therefore the contagious. Materials and Methods: To analyze of scientific articles published in the last months, about the use and effectivity of some mouthwash against COVID-19 and write an update. Rinses, as an adjunctive measure for containing the COVID-19 transmission, are important to keep in mind, but there are very few articles on COVID-19 that cover mouthwashes. Conclusions: A concentration of 1% - 1.5% hydrogen peroxide solution or 1% - 0.2% povidone-iodine seem to be an effective mouthwash to reduce the viral load in oral cavity of COVID-19. Clinical Relevance: Due to COVID-19 pandemic, we are suffering, and growing information about this virus, questions about which antiseptic rinse to use to decrease the viral load is essential.","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127478881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The aim of the present study was to evaluate the use of antimicrobials, the prescription patterns and the reason(s) for prescribing antimicrobials when treating periodontal disease in selected UK General Dental Practitioner (GDP) and Periodontal Specialists. Materials & Methods: The questionnaire consisted of 21 questions and was sent to 488 Periodontal Specialists and 488 GDPs. Data management and analysis was performed using Microsoft Excel, SPSS® version 22.0 software and frequency distributions, cross tabulation tables and graphs were constructed from the data. Any association between variables was tested at the 5 % level of significance (P≤ 0.05). Results: The questionnaires were completed by the Specialists (38.72%) (n=189) and 23.36% (n=114) of the GDPs. The results indicated that the use of systemic and local antimicrobials followed the current guidelines. Specialists prescribed more systemic antimicrobials than the GDPs, although Specialists limited the use of local antimicrobials. The GDPs reported that decision making was difficult when to use local antimicrobials although recognised that using local antimicrobials were more effective than root surface debridement alone. Other reasons for using antimicrobials were based either on the patient request or patient satisfaction with the treatment. Lower frequency of antimicrobial use was reported in regeneration and implant procedures by both Specialists and GDPs although the Specialists were more inclined to use antibiotics/antimicrobials in these procedures. Conclusions: The results of the study suggested that there was a need for dentists to follow current guidelines when prescribing antibiotics/antimicrobials in order to avoid unnecessary prescriptions, antibiotic resistance and adverse drug reactions.
{"title":"UK Specialists’ and GDPs’ Use of Systemic and Local Antimicrobial Administration in Periodontal Therapy: A Questionnaire Study","authors":"E. Padtong, W. Turner, D. Gillam","doi":"10.31038/jdmr.2020312","DOIUrl":"https://doi.org/10.31038/jdmr.2020312","url":null,"abstract":"Aim: The aim of the present study was to evaluate the use of antimicrobials, the prescription patterns and the reason(s) for prescribing antimicrobials when treating periodontal disease in selected UK General Dental Practitioner (GDP) and Periodontal Specialists. Materials & Methods: The questionnaire consisted of 21 questions and was sent to 488 Periodontal Specialists and 488 GDPs. Data management and analysis was performed using Microsoft Excel, SPSS® version 22.0 software and frequency distributions, cross tabulation tables and graphs were constructed from the data. Any association between variables was tested at the 5 % level of significance (P≤ 0.05). Results: The questionnaires were completed by the Specialists (38.72%) (n=189) and 23.36% (n=114) of the GDPs. The results indicated that the use of systemic and local antimicrobials followed the current guidelines. Specialists prescribed more systemic antimicrobials than the GDPs, although Specialists limited the use of local antimicrobials. The GDPs reported that decision making was difficult when to use local antimicrobials although recognised that using local antimicrobials were more effective than root surface debridement alone. Other reasons for using antimicrobials were based either on the patient request or patient satisfaction with the treatment. Lower frequency of antimicrobial use was reported in regeneration and implant procedures by both Specialists and GDPs although the Specialists were more inclined to use antibiotics/antimicrobials in these procedures. Conclusions: The results of the study suggested that there was a need for dentists to follow current guidelines when prescribing antibiotics/antimicrobials in order to avoid unnecessary prescriptions, antibiotic resistance and adverse drug reactions.","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"151 46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116540573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The objective of the present in vitro study was to evaluate the ability of a novel self-assembling peptide matrix gel with calcium phosphate in effectively occluding dentine tubules compared to selected desensitizing toothpastes. Methods: Mid-coronal dentine discs with a thickness of 1 mm were sectioned from caries-free human molars. The discs were etched with 6% citric acid for 2 minutes, halved and subjected to a 2-minute brushing with a novel gel (SAPM) and three selected desensitizing toothpastes ([SRP], [SRR] and [CSP]). The ability of the desensitizing gel and toothpastes to occlude the dentine tubules was assessed and compared before and after brushing using Scanning Electron Microscopy (SEM) on both etched and fractured dentine surfaces. The SEM observations were supplemented by hydraulic conductance measurements using a modified Pashley model before and after tooth brushing (n=5). Results: The results demonstrated that there was a reduction in both the number and the diameter of the open dentine tubules, which was evident for all the treated dentine discs. The particles that occluded the open dentine tubules, however had different morphologies and distribution. The self-assembling peptide matrix gel (SAPM) demonstrated the greater reduction in the number of open tubules compared to the other desensitizing toothpastes. Reductions in the hydraulic conductance measurements were observed for all tested materials (mean [SD, %]: SAPM 55.1 [12.5], SRP 64.9 [18.5], SRR 39.1 [17.1] and CSP 27.6 [6.8]). No statistically differences were observed between the SAPM and SRP, SRR toothpastes (paired t-Test; ≤0.05) although a significant difference was noted between the SAPM and the CSP toothpastes. There was an overall trend for reduction for the SAPM compared to the SRR toothpaste. Conclusion: The results would suggest that a novel self-assembling peptide matrix gel (SAPM) was effective in blocking the dentine tubules and may therefore have the potential to be an effective desensitizing product for the treatment of Dentine Hypersensitivity.
{"title":"An In Vitro Comparison of A Novel Self-Assembling Peptide Matrix Gel and Selected Desensitizing Toothpastes in Reducing Fluid Flow by Dentine Tubular Occlusion","authors":"R. Hill, H. Chen, D. A. Lysek, D. Gillam","doi":"10.21203/rs.2.16822/v1","DOIUrl":"https://doi.org/10.21203/rs.2.16822/v1","url":null,"abstract":"\u0000 Background: The objective of the present in vitro study was to evaluate the ability of a novel self-assembling peptide matrix gel with calcium phosphate in effectively occluding dentine tubules compared to selected desensitizing toothpastes. Methods: Mid-coronal dentine discs with a thickness of 1 mm were sectioned from caries-free human molars. The discs were etched with 6% citric acid for 2 minutes, halved and subjected to a 2-minute brushing with a novel gel (SAPM) and three selected desensitizing toothpastes ([SRP], [SRR] and [CSP]). The ability of the desensitizing gel and toothpastes to occlude the dentine tubules was assessed and compared before and after brushing using Scanning Electron Microscopy (SEM) on both etched and fractured dentine surfaces. The SEM observations were supplemented by hydraulic conductance measurements using a modified Pashley model before and after tooth brushing (n=5). Results: The results demonstrated that there was a reduction in both the number and the diameter of the open dentine tubules, which was evident for all the treated dentine discs. The particles that occluded the open dentine tubules, however had different morphologies and distribution. The self-assembling peptide matrix gel (SAPM) demonstrated the greater reduction in the number of open tubules compared to the other desensitizing toothpastes. Reductions in the hydraulic conductance measurements were observed for all tested materials (mean [SD, %]: SAPM 55.1 [12.5], SRP 64.9 [18.5], SRR 39.1 [17.1] and CSP 27.6 [6.8]). No statistically differences were observed between the SAPM and SRP, SRR toothpastes (paired t-Test; ≤0.05) although a significant difference was noted between the SAPM and the CSP toothpastes. There was an overall trend for reduction for the SAPM compared to the SRR toothpaste. Conclusion: The results would suggest that a novel self-assembling peptide matrix gel (SAPM) was effective in blocking the dentine tubules and may therefore have the potential to be an effective desensitizing product for the treatment of Dentine Hypersensitivity.","PeriodicalId":326702,"journal":{"name":"Journal of Dental and Maxillofacial Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116157363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：