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Beyond pancreatitis: An extreme lipase elevation in a post laparoscopic Roux-en-Y gastric bypass 超越胰腺炎:在腹腔镜Roux-en-Y胃旁路手术中脂肪酶极度升高
IF 2 Q3 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.lers.2025.04.003
Sumawadee Boonyasurak , Panumase Hirunwidchayarat , Voraboot Taweeruthana
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引用次数: 0
Research progress on carbon dioxide embolism during laparoscopic liver resection 腹腔镜肝切除术中二氧化碳栓塞的研究进展
IF 2 Q3 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.lers.2025.10.002
Zhitao Xie , Weiqi Li , Bingzhi Dong , Zihao Huang , Chenqi Jin , Hong Yu , Xin Yu
Laparoscopic liver resection (LLR) is currently the first-line treatment for multiple liver diseases. Although clinical data have proven its safety and effectiveness, bleeding and carbon dioxide (CO2) embolism are still the major complications of LLR. The objective of this review was to summarize the pathogenetic mechanism, clinical manifestations, risk factors, prophylactic measures, and treatment strategies for CO2 embolism in LLR and propose further research directions regarding these controversial issues. A narrative review of the literature from three databases, including PubMed, Embase, and Web of Science, was conducted without any date or language restrictions. The search terms included CO2 embolism, gas embolism, laparoscopy, liver resection, and hepatectomy. The incidence of CO2 embolism in LLR (1.2%–4.6%) is approximately 10 times greater than that in overall laparoscopic surgery (0.15%). Transesophageal echocardiogram is currently considered the gold standard for identifying CO2 embolism. Risk factors are multifactorial and involve patient characteristics, procedural techniques, and anesthetic management. Presently, in clinical practice, a pneumoperitoneal pressure of 10–15 mmHg is typically used to balance bleeding and CO2 embolism during LLR. The majority of observed CO2 embolism events are benign, with no significant clinical impact on short-term or long-term outcomes. However, meticulous monitoring, timely recognition, and prompt intervention are crucial during LLR to prevent life-threatening events. Future research should further refine risk stratification, validate early detection methods, and develop standardized management protocols for CO2 embolism in LLR.
腹腔镜肝切除术(LLR)是目前多种肝脏疾病的一线治疗方法。虽然临床数据已经证明其安全性和有效性,但出血和二氧化碳栓塞仍然是LLR的主要并发症。本文就LLR CO2栓塞的发病机制、临床表现、危险因素、预防措施及治疗策略进行综述,并就这些存在争议的问题提出进一步的研究方向。对PubMed、Embase和Web of Science三个数据库的文献进行了叙述性综述,没有任何日期或语言限制。搜索词包括CO2栓塞、气体栓塞、腹腔镜、肝切除术和肝切除术。LLR中CO2栓塞的发生率(1.2%-4.6%)约为腹腔镜手术的10倍(0.15%)。经食管超声心动图目前被认为是鉴别二氧化碳栓塞的金标准。危险因素是多因素的,涉及患者特征、手术技术和麻醉管理。目前,在临床实践中,通常使用10 - 15mmhg的气腹压力来平衡LLR期间的出血和二氧化碳栓塞。大多数观察到的CO2栓塞事件是良性的,对短期或长期结局没有显著的临床影响。然而,在LLR过程中,细致的监测、及时的识别和及时的干预对于预防危及生命的事件至关重要。未来的研究应进一步完善风险分层,验证早期检测方法,并制定LLR CO2栓塞的标准化管理方案。
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引用次数: 0
Endoscopic submucosal dissection versus endoscopic mucosal resection for early esophageal neoplasia: A systematic review and meta-analysis 内镜下粘膜夹层与内镜下粘膜切除术治疗早期食管肿瘤:系统回顾和荟萃分析
IF 2 Q3 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.lers.2025.09.004
Hur Abbas , Maria Murtaza , Khadija Azeem , Maryam Asad , Maham Shakeel , Irtaza Hassan , Manail Asif , Haya Kashif , Lia Anwar , Maham Abid , Hasan Anwar , Hassan Ali , Satesh Kumar , Mahima Khatri

Objective

Esophageal carcinoma (EC) is a primary global health concern, ranking as the eighth most common cancer and the sixth leading cause of cancer-related mortality. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are widely used to manage early-stage EC and Barrett’s esophagus. However, their comparative efficacy and safety remain debated. This study aims to systematically compare the safety and efficacy of ESD and EMR in the treatment of early EC and Barrett’s esophagus.

Methods

A systematic review and meta-analysis were conducted following the PRISMA 2020 guidelines. Databases, including MEDLINE (via PubMed), Google Scholar, and the Cochrane Library were searched for studies published up to October 2024. Twenty-two studies involving 3309 patients (1425 with ESD and 1884 with EMR) met the inclusion criteria. The outcomes assessed included en bloc resection, R0 resection, curative resection, local recurrence, bleeding, perforation, and stricture formation. Risk ratios (RR) with 95% CIs were calculated via a random-effects model via RevMan 5.4.

Results

ESD significantly outperformed EMR in en bloc resection (RR = 2.22, 95% CI: 1.69–2.90; p < 0.001), R0 resection (RR = 1.93, 95% CI: 1.28–2.91; p = 0.002), and curative resection rates (RR = 2.29, 95% CI: 1.52–3.46; p < 0.001). ESD was associated with lower local recurrence in patients with squamous cell carcinoma (SCC) (RR = 0.13, 95% CI: 0.06–0.30; p < 0.001), whereas recurrence was greater in patients with Barrett’s esophagus (RR = 1.67, 95% CI: 1.30–2.14; p < 0.001). No significant difference was observed in bleeding rates; however, ESD was associated with a greater risk of perforation (RR = 2.94, 95% CI: 1.31–6.60; p = 0.009).

Conclusion

ESD is more effective than EMR in achieving complete and curative resections for early EC and SCC, particularly for lesions >20 mm. However, it has a higher complication rate, especially perforation. Careful patient selection and procedural expertise are essential when choosing between the two techniques.
食管癌(EC)是全球主要的健康问题,是第八大常见癌症和第六大癌症相关死亡原因。内镜下粘膜切除(EMR)和内镜下粘膜剥离(ESD)被广泛用于治疗早期EC和Barrett食管。然而,它们的相对疗效和安全性仍存在争议。本研究旨在系统比较ESD和EMR治疗早期EC和Barrett食管的安全性和有效性。方法按照PRISMA 2020指南进行系统评价和荟萃分析。数据库包括MEDLINE(通过PubMed)、谷歌Scholar和Cochrane Library,检索了截至2024年10月发表的研究。22项研究涉及3309例患者(1425例ESD, 1884例EMR)符合纳入标准。评估的结果包括整体切除、R0切除、治愈性切除、局部复发、出血、穿孔和狭窄形成。95% ci的风险比(RR)通过RevMan 5.4的随机效应模型计算。结果esd在整体切除(RR = 2.22, 95% CI: 1.69 ~ 2.90; p < 0.001)、R0切除(RR = 1.93, 95% CI: 1.28 ~ 2.91; p = 0.002)和治愈率(RR = 2.29, 95% CI: 1.52 ~ 3.46; p < 0.001)均显著优于EMR。ESD与鳞状细胞癌(SCC)患者的局部复发率较低相关(RR = 0.13, 95% CI: 0.06-0.30; p < 0.001),而Barrett食管患者的复发率较高(RR = 1.67, 95% CI: 1.30-2.14; p < 0.001)。出血率无显著差异;然而,ESD与较高的穿孔风险相关(RR = 2.94, 95% CI: 1.31-6.60; p = 0.009)。结论esd比EMR更能实现早期EC和SCC的完全和根治性切除,特别是对20mm的病变。然而,它有较高的并发症发生率,尤其是穿孔。在两种技术之间进行选择时,仔细的患者选择和程序专业知识是必不可少的。
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引用次数: 0
Minimally invasive management of lung metastases using robotic bronchoscopy: First French experience 使用机器人支气管镜进行肺转移的微创治疗:首次法国经验
IF 2 Q3 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.lers.2025.07.003
Ilaria Ceccarelli , Hasnain Bawaadam , Christine Lorut , Nouha Chaaban , Marion Durand , Agathe Seguin-Givelet
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引用次数: 0
Enhancing surgical training through cognitive load assessment 通过认知负荷评估加强外科训练
IF 2 Q3 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.lers.2025.06.001
Yun Wu, Yile Zhu, Bin Zheng
The cognitive load plays a key role in surgical education, influencing task performance and skill acquisition. This review explores three primary approaches to assessing cognitive load in the surgical context—paper-based measures, physiological measures, and performance-based measures—and highlights their relevance and applications in surgical education. Paper-based tools, such as the NASA Task Load Index and its surgical adaptation, the Surgery Task Load Index, offer simplicity but lack real-time insight. Physiological measures, including heart rate, eye tracking, and electrodermal activity, provide objective and timely data. Neuroimaging techniques, such as electroencephalography and functional near-infrared spectroscopy, provide direct evidence of brain activity but face challenges such as cost and complexity. Performance-based metrics, such as secondary tasks, infer cognitive load from working memory capacity. Accurate assessment of cognitive load can improve training outcomes by adapting demands to cognitive capacity. Future directions include the development of more accurate, multimodal, and user-friendly tools for dynamic, timely assessment, ultimately advancing personalized surgical training and improving patient care.
认知负荷在外科教育中起着关键作用,影响任务绩效和技能习得。这篇综述探讨了三种主要的方法来评估手术环境中的认知负荷-基于纸的测量,生理测量和基于性能的测量-并强调了它们在外科教育中的相关性和应用。基于纸张的工具,如NASA任务负荷指数及其外科适应性的手术任务负荷指数,提供了简单性,但缺乏实时洞察力。生理测量,包括心率、眼动追踪和皮电活动,提供了客观和及时的数据。神经成像技术,如脑电图和功能性近红外光谱,提供了大脑活动的直接证据,但面临成本和复杂性等挑战。基于表现的指标,如次要任务,从工作记忆容量推断认知负荷。准确评估认知负荷可以通过适应认知能力的需求来改善训练效果。未来的发展方向包括开发更准确、多模式、用户友好的工具,用于动态、及时的评估,最终推进个性化手术培训,改善患者护理。
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引用次数: 0
Comparison of outcomes in robot-assisted colon cancer surgery using Da Vinci Xi, Hugo™ RAS, and Versius®: The COMPAR-CRC multiplatform study 使用Da Vinci Xi、Hugo™RAS和Versius®进行机器人辅助结肠癌手术的结果比较:comar - crc多平台研究
IF 2 Q3 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.lers.2025.10.001
Corrado Pedrazzani , Giulia Turri , Michele Genna , Alessandro Valdegamberi , Andrea Ballarin , Ernesto De Giulio , Ruben Sciortino , Simone Priolo , Callisto Marco Bravi , Andrea Ruzzenente

Objective

Since the introduction of the Da Vinci® robotic system, robot-assisted colon resection has gained popularity because of its the potential technical advantages. Recently, two new CE-marked platforms have become available in Europe: Hugo™ RAS and Versius®. We present the first prospective case series comparing these three robotic systems.

Methods

This exploratory, prospective study enrolled 45 consecutive adult patients undergoing robotic colon resection between February and December 2024, as part of the COMPAR trial. Two experienced colorectal surgeons performed all procedures across two surgical units. Each robotic platform was used in 15 cases. The primary outcomes were conversion to laparoscopy or open surgery and intra-operative complications. The secondary outcomes included post-operative recovery, oncological results, and platform-specific technical parameters.

Results

The mean age was 66.8 years and 68.9% of patients underwent surgery for colon cancer. No conversions occurred in the Da Vinci group, whereas 2 and 3 conversions to laparoscopy were recorded with Hugo™ RAS and Versius®, respectively. One intra-operative instrument malfunction occurred with Hugo™ RAS, and one surgical complication was reported in each group. No significant differences emerged in post-operative recovery or oncological outcomes. Versius® cases required more frequent use of laparoscopic energy devices (p < 0.001). Hugo™ RAS was associated with a longer total operating room time (p = 0.022) and longer incision length (p = 0.005).

Conclusion

Robotic colorectal surgery with all three platforms is feasible when performed by expert surgeons. While early outcomes are encouraging, larger comparative trials are needed to confirm differences in recovery and oncological efficacy.
自达芬奇®机器人系统推出以来,机器人辅助结肠切除术因其潜在的技术优势而受到欢迎。最近,两个新的ce认证平台已经在欧洲上市:Hugo™RAS和Versius®。我们提出了比较这三种机器人系统的第一个前瞻性案例系列。这项探索性、前瞻性研究招募了45名连续的成年患者,于2024年2月至12月期间接受了机器人结肠切除术,作为COMPAR试验的一部分。两名经验丰富的结直肠外科医生在两个外科单位进行了所有手术。每个机器人平台使用15例。主要结局是转为腹腔镜或开放手术和术中并发症。次要结果包括术后恢复、肿瘤结果和特定平台的技术参数。结果平均年龄为66.8岁,68.9%的患者接受了结肠癌手术。Da Vinci组未发生转换,而Hugo™RAS和Versius®分别记录了2例和3例腹腔镜转换。Hugo™RAS术中器械发生1例故障,每组报告1例手术并发症。术后恢复和肿瘤预后无显著差异。Versius®病例需要更频繁地使用腹腔镜能量装置(p < 0.001)。Hugo™RAS与较长的总手术室时间(p = 0.022)和较长的切口长度(p = 0.005)相关。结论在专家的指导下,三种平台的机器人结直肠手术是可行的。虽然早期结果令人鼓舞,但需要更大规模的比较试验来确认恢复和肿瘤疗效的差异。
{"title":"Comparison of outcomes in robot-assisted colon cancer surgery using Da Vinci Xi, Hugo™ RAS, and Versius®: The COMPAR-CRC multiplatform study","authors":"Corrado Pedrazzani ,&nbsp;Giulia Turri ,&nbsp;Michele Genna ,&nbsp;Alessandro Valdegamberi ,&nbsp;Andrea Ballarin ,&nbsp;Ernesto De Giulio ,&nbsp;Ruben Sciortino ,&nbsp;Simone Priolo ,&nbsp;Callisto Marco Bravi ,&nbsp;Andrea Ruzzenente","doi":"10.1016/j.lers.2025.10.001","DOIUrl":"10.1016/j.lers.2025.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>Since the introduction of the Da Vinci® robotic system, robot-assisted colon resection has gained popularity because of its the potential technical advantages. Recently, two new CE-marked platforms have become available in Europe: Hugo™ RAS and Versius®. We present the first prospective case series comparing these three robotic systems.</div></div><div><h3>Methods</h3><div>This exploratory, prospective study enrolled 45 consecutive adult patients undergoing robotic colon resection between February and December 2024, as part of the COMPAR trial. Two experienced colorectal surgeons performed all procedures across two surgical units. Each robotic platform was used in 15 cases. The primary outcomes were conversion to laparoscopy or open surgery and intra-operative complications. The secondary outcomes included post-operative recovery, oncological results, and platform-specific technical parameters.</div></div><div><h3>Results</h3><div>The mean age was 66.8 years and 68.9% of patients underwent surgery for colon cancer. No conversions occurred in the Da Vinci group, whereas 2 and 3 conversions to laparoscopy were recorded with Hugo™ RAS and Versius®, respectively. One intra-operative instrument malfunction occurred with Hugo™ RAS, and one surgical complication was reported in each group. No significant differences emerged in post-operative recovery or oncological outcomes. Versius® cases required more frequent use of laparoscopic energy devices (<em>p</em> &lt; 0.001). Hugo™ RAS was associated with a longer total operating room time (<em>p</em> = 0.022) and longer incision length (<em>p</em> = 0.005).</div></div><div><h3>Conclusion</h3><div>Robotic colorectal surgery with all three platforms is feasible when performed by expert surgeons. While early outcomes are encouraging, larger comparative trials are needed to confirm differences in recovery and oncological efficacy.</div></div>","PeriodicalId":32893,"journal":{"name":"Laparoscopic Endoscopic and Robotic Surgery","volume":"8 4","pages":"Pages 178-184"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine learning-guided prevention and management of low anterior resection syndrome: Development of an XGBoost prediction model and validation via SHAP 机器学习引导下下前切除术综合征的预防和管理:XGBoost预测模型的建立和SHAP验证
IF 2 Q3 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.lers.2025.09.002
Yangtao Pan , Chaojie Huang , Xinjie Zhang , Zhentian Xu , Bingjun Bai , Min Chen , Weifeng Lao

Objective

Colorectal cancer is among the top three cancers in terms of incidence and mortality worldwide. Although laparoscopic and robotic-assisted sphincter-preserving surgeries reduce permanent colostomy rates to under 20%, 60%–80% of patients develop postoperative low anterior resection syndrome (LARS), nearly half of whom progress to major LARS. This study aims to develop a high-precision machine learning model for predicting LARS, thereby optimizing the early identification, prevention, and management of major LARS in rectal cancer patients, providing a reliable tool for personalized clinical decision-making.

Methods

This retrospective study screened 3,986 rectal cancer patients who underwent laparoscopic and robotic-assisted sphincter-preserving surgeries from January 2012 to January 2022. Key predictors were identified via LASSO regression to develop an XGBoost machine learning model for major LARS prediction, which was validated via SHapley additive exPlanations (SHAP).

Results

The XGBoost model achieved 93% accuracy for major LARS prediction, with 84% precision, 74% recall, and an F1 score of 0.78, outperforming POLARS (69% accuracy, 82% precision, 36% recall, F1 score of 0.5). SHAP analysis confirmed that tumor height was the strongest predictor, followed by age at surgery, stoma status, preoperative radiotherapy, and gender. The model enabled real-time risk stratification, reducing overtreatment in non-LARS and minor LARS patients in clinical application. The model has been integrated into a user-friendly offline software (XGBoostLARS) and has been applied to the early clinical identification, prediction, and management of LARS.

Conclusion

This high-precision XGBoost model optimizes the early identification, prevention, and management of major LARS, leading to new progress in personalized treatment for rectal cancer survivors.
目的结直肠癌是世界范围内发病率和死亡率排名前三的癌症之一。尽管腹腔镜和机器人辅助的保留括约肌手术将永久性结肠造口率降低到20%以下,但60%-80%的患者会出现术后低前切除术综合征(LARS),其中近一半会发展为严重LARS。本研究旨在建立预测LARS的高精度机器学习模型,从而优化直肠癌患者主要LARS的早期识别、预防和管理,为个性化临床决策提供可靠的工具。方法回顾性研究筛选2012年1月至2022年1月期间接受腹腔镜和机器人辅助保括约肌手术的3986例直肠癌患者。通过LASSO回归确定关键预测因子,开发用于主要LARS预测的XGBoost机器学习模型,并通过SHapley加性解释(SHAP)验证该模型。结果XGBoost模型对主要LARS预测准确率为93%,准确率为84%,召回率为74%,F1分数为0.78,优于POLARS模型(准确率为69%,准确率为82%,召回率为36%,F1分数为0.5)。SHAP分析证实肿瘤高度是最强的预测因子,其次是手术年龄、造口状态、术前放疗和性别。该模型实现了实时风险分层,减少了临床应用中非LARS和轻微LARS患者的过度治疗。该模型已集成到用户友好的离线软件(XGBoostLARS)中,并已应用于LARS的早期临床识别、预测和管理。结论高精度的XGBoost模型优化了主要LARS的早期识别、预防和管理,为直肠癌幸存者的个性化治疗带来了新的进展。
{"title":"Machine learning-guided prevention and management of low anterior resection syndrome: Development of an XGBoost prediction model and validation via SHAP","authors":"Yangtao Pan ,&nbsp;Chaojie Huang ,&nbsp;Xinjie Zhang ,&nbsp;Zhentian Xu ,&nbsp;Bingjun Bai ,&nbsp;Min Chen ,&nbsp;Weifeng Lao","doi":"10.1016/j.lers.2025.09.002","DOIUrl":"10.1016/j.lers.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>Colorectal cancer is among the top three cancers in terms of incidence and mortality worldwide. Although laparoscopic and robotic-assisted sphincter-preserving surgeries reduce permanent colostomy rates to under 20%, 60%–80% of patients develop postoperative low anterior resection syndrome (LARS), nearly half of whom progress to major LARS. This study aims to develop a high-precision machine learning model for predicting LARS, thereby optimizing the early identification, prevention, and management of major LARS in rectal cancer patients, providing a reliable tool for personalized clinical decision-making.</div></div><div><h3>Methods</h3><div>This retrospective study screened 3,986 rectal cancer patients who underwent laparoscopic and robotic-assisted sphincter-preserving surgeries from January 2012 to January 2022. Key predictors were identified via LASSO regression to develop an XGBoost machine learning model for major LARS prediction, which was validated via SHapley additive exPlanations (SHAP).</div></div><div><h3>Results</h3><div>The XGBoost model achieved 93% accuracy for major LARS prediction, with 84% precision, 74% recall, and an F1 score of 0.78, outperforming POLARS (69% accuracy, 82% precision, 36% recall, F1 score of 0.5). SHAP analysis confirmed that tumor height was the strongest predictor, followed by age at surgery, stoma status, preoperative radiotherapy, and gender. The model enabled real-time risk stratification, reducing overtreatment in non-LARS and minor LARS patients in clinical application. The model has been integrated into a user-friendly offline software (XGBoostLARS) and has been applied to the early clinical identification, prediction, and management of LARS.</div></div><div><h3>Conclusion</h3><div>This high-precision XGBoost model optimizes the early identification, prevention, and management of major LARS, leading to new progress in personalized treatment for rectal cancer survivors.</div></div>","PeriodicalId":32893,"journal":{"name":"Laparoscopic Endoscopic and Robotic Surgery","volume":"8 4","pages":"Pages 185-190"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The feasibility and early outcomes of fully robotic recipient adult living donor liver transplantation: A narrative review 完全机器人受体成人活体肝移植的可行性和早期结果:综述
IF 2 Q3 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.lers.2025.11.002
Ahmad Mahamid
Robotic surgery has emerged as a new frontier in liver transplantation. Given the novelty of its application to recipient procedures, a comprehensive overview is crucial. This narrative review synthesizes the fragmented, foundational data on fully robotic recipient adult living donor liver transplantation (LDLT) on the basis of an appraisal of initial case reports and preliminary comparative studies. The literature was identified via PubMed. The literature demonstrates the technical feasibility and favorable safety profile of the robotic approach. A significant reduction in morbidity was observed, as evidenced by a lower comprehensive complication index, reduced blood loss and transfusion need, and a lower incidence of postoperative infections. These benefits were reflected in significantly shorter intensive care unit and hospital stays. While the robotic approach was associated with prolonged operative and ischemia times, the studies revealed that these approaches did not compromise outcomes, with higher 6-month recipient survival noted in the robotic group. Fully robotic recipient LDLT is a groundbreaking technique, although the current evidence consists of initial case reports and non-randomized comparative data from a single center. The available literature suggests a promising safety profile and significant short-term benefits, but these preliminary findings require validation through multicenter, high-level research.
机器人手术已经成为肝移植的新前沿。鉴于其应用于接受者程序的新颖性,全面的概述是至关重要的。本文在初步病例报告和初步比较研究的基础上,综合了全机器人受体成人活体肝移植(LDLT)的零散基础数据。这些文献是通过PubMed确定的。文献证明了机器人方法的技术可行性和良好的安全性。观察到发病率显著降低,综合并发症指数较低,失血和输血需求减少,术后感染发生率较低。这些好处体现在重症监护病房和住院时间显著缩短。虽然机器人入路与延长手术时间和缺血时间有关,但研究表明,这些入路并不影响结果,机器人组的6个月生存率更高。完全机器人受体LDLT是一项突破性的技术,尽管目前的证据包括来自单个中心的初始病例报告和非随机比较数据。现有文献表明其具有良好的安全性和显著的短期效益,但这些初步发现需要通过多中心、高水平的研究来验证。
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引用次数: 0
Extended-view totally extraperitoneal approach for midline primary and incisional ventral hernia repair: Initial results and experience from a single institution in Vietnam 扩展视点完全腹膜外入路用于中线原发性和切口腹疝修补:来自越南一家机构的初步结果和经验
IF 2 Q3 Medicine Pub Date : 2025-07-17 DOI: 10.1016/j.lers.2025.07.002
Van Phu La , Vinh Phuc La , Hai Duong Tong , Minh Dien Tran , Tuan Tu Duong , Vimal Kumar Vasudeavan , Hadinata Prana , Anh Vu Doan

Objective

Abdominal wall hernias, particularly midline primary and incisional types, represent a common and challenging surgical condition. The extended-view totally extraperitoneal (e-TEP) technique has recently been adapted for ventral hernia repair, offering potential advantages over other approaches. This study aimed to evaluate the initial outcomes and institutional experience of the e-TEP technique for midline primary and incisional ventral hernia repair at a tertiary center in Vietnam.

Methods

This prospective descriptive study was conducted on 65 patients with midline primary or incisional ventral hernias who underwent e-TEP repair between June 2022 and August 2024. All procedures were performed by two experienced surgeons at the Department of General Surgery, Can Tho General Hospital, Vietnam. Follow-up continued until February 2025. Data were collected and analyzed on demographics, clinical characteristics, surgical details, postoperative outcomes, and recurrence.

Results

A total of 65 patients, with a mean age of 57.9 ± 12.6 years, a mean BMI of 25.0 ± 3.3 kg/m2, and 47 (72.3%) female, were included. The types of hernias included primary hernias in 63.1% (41 patients) and incisional hernias in 36.9% (24 patients). Among the incisional hernias, 3 cases were recurrences. The median defect area was 9 cm2 (range, 1–50 cm2). A 15 cm × 15 cm mesh was used in nearly all cases (98.5%). The mean operating time was 131.9 ± 51.8 min, with no conversions to open repair or other procedures, and no intraoperative complications were observed. Nine patients (13%) experienced postoperative complications, with seroma being the most common (5 cases). Two patients sustained intestinal injuries that required reoperation, one developed a wound infection and one reported postoperative skin paresthesia. The mean visual analogue scale pain scores at postoperative 24 hours, 48 hours, and at discharge were 4.3 ± 1.3, 3.0 ± 1.5, and 1.0 ± 0.4, respectively. The mean postoperative hospital stay was 4.52 ± 2.24 d. Only one case of recurrence (1.5%) was observed, and no patient reported chronic pain during the mean follow-up period of 14.5 ± 7.6 m.

Conclusion

The e-TEP technique for midline primary and incisional ventral hernia repair is a feasible and safe option when performed by experienced surgeons. It offers a low rate of complications, short hospital stay, and minimal recurrence rates. This technique can be considered a viable alternative for the management of midline ventral hernias, with promising short-term outcomes.
腹壁疝,特别是中线原发性和切口型腹壁疝,是一种常见且具有挑战性的手术条件。全腹膜外扩视野(e-TEP)技术最近被应用于腹疝修补,与其他入路相比具有潜在的优势。本研究旨在评估e-TEP技术在越南三级中心中线原发性和切口腹疝修复中的初步结果和机构经验。方法本前瞻性描述性研究对2022年6月至2024年8月期间接受e-TEP修复的65例中线原发性或切口腹疝患者进行了研究。所有手术均由越南芹苴总医院普通外科的两名经验丰富的外科医生进行。后续行动一直持续到2025年2月。收集和分析人口统计学、临床特征、手术细节、术后结果和复发的数据。结果共纳入65例患者,平均年龄57.9±12.6岁,平均BMI为25.0±3.3 kg/m2,女性47例(72.3%)。疝类型包括原发性疝41例(63.1%)和切口疝24例(36.9%)。切口疝中复发3例。中位缺损面积为9 cm2(范围1-50 cm2)。几乎所有病例(98.5%)均使用15cm × 15cm补片。平均手术时间131.9±51.8 min,无中转开腹修复等手术,无术中并发症。术后出现并发症9例(13%),以血清肿最为常见(5例)。两名患者持续肠道损伤,需要再次手术,一名出现伤口感染,一名报告术后皮肤感觉异常。术后24小时、48小时和出院时视觉模拟评分的平均疼痛评分分别为4.3±1.3、3.0±1.5和1.0±0.4。术后平均住院时间为4.52±2.24 d,仅有1例复发(1.5%),平均随访时间为14.5±7.6 m,无患者报告慢性疼痛。结论在经验丰富的外科医生的指导下,e-TEP技术用于中线原发性和切口腹疝修补是一种安全可行的选择。它的并发症发生率低,住院时间短,复发率低。该技术可被认为是治疗中线腹疝的可行替代方法,具有良好的短期效果。
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引用次数: 0
The cost–efficiency of preoperative phenazopyridine use in ureteral jet visualization at time of cystoscopy following minimally invasive hysterectomy 微创子宫切除术后膀胱镜检查输尿管射孔时术前应用非那吡啶的成本效益
IF 2 Q3 Medicine Pub Date : 2025-07-10 DOI: 10.1016/j.lers.2025.07.001
Caitlin H. Waters , Maame Yaa Brako , Heidi Preis , Lokesh Patil , Nicole Massad , Jennifer Blaber , Sara Kim , Xun Lian

Objective

To determine the impact of planned preoperative phenazopyridine administration on operative times and costs compared with as-needed intravenous agent use during routine cystoscopy following minimally invasive hysterectomy for benign indications.

Method

This prospective cohort study examined patients who underwent laparoscopic or robotic-assisted total or supracervical hysterectomy for benign indications between January 27, 2023 and March 11, 2024, with one of our minimally invasive gynecologic surgeons at Stony Brook University Hospital. Patients were assigned to the non-phenazopyridine group or the phenazopyridine group. The time needed to visualize the ureteral jets during cystoscopy and the total surgery duration were recorded. A cost analysis was then performed.

Results

In total, 106 patients were included, with 53 patients in each group. Compared with the non-phenazopyridine group, the phenazopyridine group had significantly shorter times from the start of cystoscopy to visualization of the first ureteral jet (31 s vs. 42 s, p < 0.05). However, there were no significant differences observed for visualization of the second jet, total jet time, or surgery duration. Two patients in the non-phenazopyridine group required the administration of intravenous agents intraoperatively. Routine phenazopyridine was found to be more cost-efficient when medication costs and operative times were examined.

Conclusion

Routine phenazopyridine use does not significantly shorten overall cystoscopy times, but it is the more cost-efficient option given increased rates of costly intravenous medication use in the non-phenazopyridine group.
目的比较良性微创子宫切除术后常规膀胱镜检查时,术前计划给药非那吡啶与按需静脉给药对手术时间和费用的影响。方法本前瞻性队列研究调查了2023年1月27日至2024年3月11日期间在石溪大学医院接受腹腔镜或机器人辅助全子宫切除术或宫颈上子宫切除术的良性指征患者。患者被分为非那唑吡啶组和非那唑吡啶组。记录膀胱镜观察输尿管射孔所需时间及手术总时间。然后进行成本分析。结果共纳入106例患者,每组53例。与非那唑吡啶组相比,非那唑吡啶组从膀胱镜检查开始到输尿管第一射道可见的时间明显缩短(31 s vs. 42 s, p <;0.05)。然而,在第二次喷射的可视化、总喷射时间或手术持续时间方面,没有观察到显著差异。非那唑吡啶组2例患者需要术中静脉注射药物。当检查药物费用和手术时间时,发现常规非那吡啶更具成本效益。结论常规使用非那氮吡啶并不能显著缩短膀胱镜检查总时间,但在非那氮吡啶组,由于昂贵的静脉药物使用率增加,常规使用非那氮吡啶是更经济有效的选择。
{"title":"The cost–efficiency of preoperative phenazopyridine use in ureteral jet visualization at time of cystoscopy following minimally invasive hysterectomy","authors":"Caitlin H. Waters ,&nbsp;Maame Yaa Brako ,&nbsp;Heidi Preis ,&nbsp;Lokesh Patil ,&nbsp;Nicole Massad ,&nbsp;Jennifer Blaber ,&nbsp;Sara Kim ,&nbsp;Xun Lian","doi":"10.1016/j.lers.2025.07.001","DOIUrl":"10.1016/j.lers.2025.07.001","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the impact of planned preoperative phenazopyridine administration on operative times and costs compared with as-needed intravenous agent use during routine cystoscopy following minimally invasive hysterectomy for benign indications.</div></div><div><h3>Method</h3><div>This prospective cohort study examined patients who underwent laparoscopic or robotic-assisted total or supracervical hysterectomy for benign indications between January 27, 2023 and March 11, 2024, with one of our minimally invasive gynecologic surgeons at Stony Brook University Hospital. Patients were assigned to the non-phenazopyridine group or the phenazopyridine group. The time needed to visualize the ureteral jets during cystoscopy and the total surgery duration were recorded. A cost analysis was then performed.</div></div><div><h3>Results</h3><div>In total, 106 patients were included, with 53 patients in each group. Compared with the non-phenazopyridine group, the phenazopyridine group had significantly shorter times from the start of cystoscopy to visualization of the first ureteral jet (31 s vs. 42 s, <em>p</em> &lt; 0.05). However, there were no significant differences observed for visualization of the second jet, total jet time, or surgery duration. Two patients in the non-phenazopyridine group required the administration of intravenous agents intraoperatively. Routine phenazopyridine was found to be more cost-efficient when medication costs and operative times were examined.</div></div><div><h3>Conclusion</h3><div>Routine phenazopyridine use does not significantly shorten overall cystoscopy times, but it is the more cost-efficient option given increased rates of costly intravenous medication use in the non-phenazopyridine group.</div></div>","PeriodicalId":32893,"journal":{"name":"Laparoscopic Endoscopic and Robotic Surgery","volume":"8 3","pages":"Pages 128-133"},"PeriodicalIF":2.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Laparoscopic Endoscopic and Robotic Surgery
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