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Amphotericin B Revisited 两性霉素B
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_82_21
Sahil Kumar, V. Roy
Amphotericin B, one of the first systemic antifungal agents, has been in use since the past six decades. In light of the recent outbreak of mucormycosis (black fungus) cases during the second coronavirus disease 2019 wave in India, the relevance of knowing the chief aspects of this drug has been renewed. This drug review attempts to revisit the important details available about this agent, which will be of use to the clinician.
两性霉素B是最早的系统性抗真菌药物之一,在过去的60年里一直在使用。鉴于最近在印度2019年第二波冠状病毒病期间爆发了毛霉病(黑菌)病例,了解这种药物的主要方面的重要性得到了重申。本药物审查试图重新审视该药物的重要细节,这将对临床医生有用。
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引用次数: 0
Herpes Zoster Oticus: A Morbid Clinical Entity 带状疱疹:一种病态的临床实体
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_80_20
S. Swain, R. Paul
The reactivation of varicella zoster virus (VZV) at the geniculate ganglion of the facial nerve results in herpes zoster virus. Patients of herpes zoster oticus (HZO) often present with symptoms related to the cochleovestibular dysfunction along with otalgia and vesicular eruption at the pinna and external auditory canal. Patients of HZO usually present with hearing loss, vertigo, and facial nerve paralysis. When it is associated with facial nerve paralysis, HZO is called Ramsay Hunt syndrome (RHS). In the majority of cases, patients with vertigo have hearing loss, whereas patients without hearing loss have no vertigo. It is a self-limiting viral disease and the morbidity is often caused due to facial nerve paralysis. If HZO is not diagnosed immediately and treated timely often it progress to RHS. Clinician education is vital for detecting the HZO/RHS at an early stage so that facial nerve paralysis can be prevented along with associated morbidity. In this review article, we discuss the current concept and recent advances in the etiopathology, diagnosis, and treatment of HZO.
水痘带状疱疹病毒(VZV)在面神经膝状神经节处的再活化产生带状疱疹病毒。带状疱疹(HZO)患者通常表现为耳蜗前庭功能障碍,耳痛,耳廓和外耳道水疱疹。HZO患者通常表现为听力丧失、眩晕和面神经麻痹。当它与面神经麻痹相关联时,被称为拉姆齐·亨特综合征(RHS)。在大多数情况下,眩晕患者有听力损失,而没有听力损失的患者没有眩晕。它是一种自限性病毒性疾病,常因面神经麻痹而发病。如果HZO没有得到及时诊断和治疗,通常会发展为RHS。临床医生教育对于早期发现HZO/RHS至关重要,这样可以预防面神经麻痹以及相关的发病率。在这篇综述文章中,我们讨论了目前的概念和最近的进展,在病因,诊断和治疗HZO。
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引用次数: 4
Covid: Seen Through Prism of A Doctor Patient Covid:通过医生病人的棱镜看到的
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_90_21
Kirti Singh
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引用次数: 0
Experience of Orthopedic Surgeons Managing COVID Patients at the Peak of Second Wave in a COVID-dedicated Hospital: A Guidance for Future Waves 整形外科医生在第二波新冠肺炎疫情高峰期管理新冠肺炎患者的经验:对未来疫情的指导
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_72_21
S. Sural, T. Suri, Yasim Khan, P. Yadav, Abhay Meena, R. Yadav, L. Maini, Vinod Kumar
Introduction: The second wave of the severe acute respiratory syndrome coronavirus-2 pandemic in April 2021 had a sudden deluge of moderate to severe patients getting admitted to the orthopedics block, due to scarcity of beds in the medical wards, high dependency and intensive care areas of the hospital. This study is an analysis of these patients managed in the orthopedics block by orthopedic surgeons, which may be useful to formulate guidelines for the management of patients in future waves of the coronavirus disease 2019 (COVID-19) pandemic. Methods: The data of patients were collected by orthopedic residents from the Google sheet which was uploaded daily as part of the hospital data. The data from Google sheet were downloaded and compiled into an excel workbook and analyzed for patient progress, outcome, comorbidities, treatment given, oxygen management, and death analysis. Results: The data of 319 patients admitted from April 17, 2021 to May 20, 2021 in orthopedic block depicted successful recovery and discharge of 160 patients, worsening and transfer to higher wards for 126 patients and 33 deaths. The average age of these patients was 53.43 years with male preponderance (71% male). At the time of admission, 78.05% were reverse transcription polymerase chain reaction/rapid antigen test positive and 21.9% were COVID suspects. The patient’s disease status on arrival was found to be mild in 21.3%, moderate in 43.8%, and severe in 34.7%. The most common comorbidity was hypertension in 39 patients followed by diabetes in 29 patients. The average number of days of hospital stay was 5.48 days. Conclusion: Medical professionals other than critical care medicine can be frontline care providers who can guide the ancillary departments at the peak of pandemic waves. Adherence to the standard operating protocols and interdepartmental coordination need to be effectively managed. This study can be used to formulate guidelines for further improvement in COVID patient care in case of future waves of this pandemic.
简介:2021年4月,第二波严重急性呼吸系统综合征冠状病毒2型疫情突然爆发,由于医院医疗病房床位短缺、高度依赖性和重症监护区,大量中重度患者住进了骨科病房。这项研究是对整形外科医生在整形外科区块管理的这些患者的分析,这可能有助于制定2019冠状病毒病(新冠肺炎)大流行未来几波患者的管理指南。方法:骨科住院医师从谷歌表单中收集患者数据,该表单作为医院数据的一部分每天上传。谷歌表单中的数据被下载并汇编成excel工作簿,并分析患者的进展、结果、合并症、治疗、氧气管理和死亡分析。结果:2021年4月17日至2021年5月20日,319名骨科住院患者的数据显示,160名患者成功康复出院,126名患者病情恶化并转移到更高的病房,33人死亡。这些患者的平均年龄为53.43岁,男性占优势(71%为男性)。入院时,78.05%的患者为逆转录聚合酶链式反应/快速抗原检测阳性,21.9%的患者为新冠肺炎疑似患者。患者抵达时的疾病状况为轻度21.3%,中度43.8%,重度34.7%。最常见的合并症是39名患者的高血压,其次是29名患者的糖尿病。平均住院天数为5.48天。结论:重症医学以外的医疗专业人员可以成为一线护理人员,在疫情高峰期指导辅助部门。必须有效管理遵守标准作业规程和部门间协调的情况。这项研究可用于制定进一步改善新冠肺炎患者护理的指导方针,以防未来出现新冠肺炎疫情。
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引用次数: 0
Assessment and Comparison of the Mental Health Status of Patients Seeking Psychiatry Facilities in Pre-lockdown and Post-lockdown Period During COVID-19 Pandemic: A Retrospective Cross-Sectional Study in a Tertiary Care Centre in a Hilly Region of North India COVID-19大流行期间在封锁前和封锁后寻求精神病学设施的患者心理健康状况的评估和比较:在印度北部丘陵地区三级保健中心进行的回顾性横断面研究
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_29_21
D. Sharma, S. Garg, Anchal Sharma, D. Sharma, Nidhi Sharma, Simran Gupta, Shiva Sharma
Background: The servicing and framework for mental health care accessible to population have been affected during the unprecedented times of coronavirus disease (COVID-19) pandemic. The new and almost exclusive method to maintain a therapeutic alliance with these patients has been the recently evolving telepsychiatry services. Aim and Objectives: The main aim of the study was to assess and compare the mental health status of patients seeking available psychiatry facilities in pre-lockdown and post-lockdown period during COVID-19 pandemic. Methodology: This was a retrospective cross-sectional study that was conducted in a tertiary care hospital in a hilly region of North India. The registered data was analyzed between January 1, 2020 to March 21, 2020 to gather the information of patients about sociodemographic profile and clinical diagnosis on the basis of International Classification of Diseases-10. The retrieved data constituted 499 new consecutive patients during this period. Then in the post-lockdown phase after the resumption of OPD services in the institute (May 3, 2020), the data collection was initiated to collect a similar sample size of new consecutive patients (501). These data were collected over 151 days (May 3, 2020 to September 30, 2020). Results: A total number of 1000 patients were analyzed. Majority of the patients were male (66%) and within 19 to 60 years of age (85–90%). The average number of patients (3.31) seen per day was less and the average age of the patients (39.17 years, standard deviation = 14.37) was significantly higher in the post-lockdown phase. The most common diagnostic group consisted of neurotic/stress-related/somatoform disorders. As compared to the pre-lockdown period, a significantly (P < 0.001) lower number of patients diagnosed with substance use disorders and a significantly (P < 0.001) higher number of patients diagnosed with psychotic disorders along with anxiety disorders availed the available psychiatry services in the period of COVID-19 pandemic. Conclusion: Sudden cessation of the psychiatry services further precipitated the deterioration of mental health of the patients. There is an urgent demand for services to adapt to changing scenarios with emphasis on practical approaches to help the mentally ill people especially in geographically difficult hilly areas.
背景:在前所未有的冠状病毒病(COVID-19)大流行时期,人群可获得的精神卫生保健服务和框架受到了影响。最近发展的远程精神病学服务是与这些患者保持治疗联盟的新方法,几乎是唯一的方法。目的和目的:本研究的主要目的是评估和比较COVID-19大流行期间封锁前和封锁后寻求可用精神病学设施的患者的心理健康状况。方法:这是一项回顾性横断面研究,在印度北部丘陵地区的三级保健医院进行。对2020年1月1日至2020年3月21日的登记数据进行分析,根据国际疾病分类-10收集患者的社会人口学特征和临床诊断信息。在此期间,检索到的数据包括499名新的连续患者。然后在该研究所恢复门诊服务后的封锁后阶段(2020年5月3日),开始收集数据,收集类似样本量的新连续患者(501例)。这些数据收集了151天(2020年5月3日至2020年9月30日)。结果:共分析了1000例患者。大多数患者为男性(66%),年龄在19 ~ 60岁之间(85 ~ 90%)。封锁后阶段平均每天就诊人数(3.31人)较少,患者平均年龄(39.17岁,标准差= 14.37)明显较高。最常见的诊断组包括神经症/压力相关/躯体形式障碍。与封锁前相比,在2019冠状病毒病大流行期间,被诊断患有物质使用障碍的患者人数显著(P < 0.001)减少,被诊断患有精神障碍和焦虑症的患者人数显著(P < 0.001)增加。结论:突然停止精神科服务进一步加剧了患者心理健康状况的恶化。迫切需要服务,以适应不断变化的情况,强调实际的方法来帮助精神病人,特别是在地理上困难的山区。
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引用次数: 0
Impact of COVID-19 on the Work Performance of Healthcare Workers in Neurosurgery Operation Theater at a Tertiary Care Institute: A Pilot Study 新冠肺炎疫情对某三级医疗机构神经外科手术室医护人员工作绩效影响的初步研究
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_30_21
Katyal Abhishek, Modi Parth, Raizada Neeraj, S. Daljit
Background: The novel corona virus disease 2019 (COVID-19) pandemic had a massive impact on healthcare systems, increasing the risks of psychologic distress in health professionals in response to chronic emotional and interpersonal stressors on the job; especially associated with surgical care. Aims and Objectives: To assess the impact of COVID-19 on the psychologic health and work performance of healthcare workers (HCWs) in operation theaters (OTs). Methodology: A questionnaire-based survey study was conducted among health professionals associated with neurosurgery OT. Results: Sixty-five HCWs (including doctors, nursing staff, and other HCWs) participated in the survey. The fear of spread of COVID-19 infection to family members was found in majority of HCWs especially nursing staff (96%). The fear of COVID-related death was least among the other HCWs (8%). Majority of the HCWs followed COVID protocols at work place. Transportation issues were a major complaint by other HCWs (67%), whereas majority of the HCWs (71%) were of the opinion that donning and doffing practices affected their daily work routine. Conclusion: Fears and stigmas associated with COVID −19 had an impact on the psychosocial health of HCWs in the neurosurgery OT and affected their workplace performance.
背景:2019新型冠状病毒病(新冠肺炎)大流行对医疗系统产生了巨大影响,增加了卫生专业人员在应对工作中的慢性情绪和人际压力时出现心理困扰的风险;尤其是与外科护理相关的。目的:评估新冠肺炎对手术室医护人员心理健康和工作表现的影响。方法:在与神经外科OT相关的卫生专业人员中进行了一项基于问卷的调查研究。结果:65名医务人员(包括医生、护理人员和其他医务人员)参加了调查。大多数医务人员,尤其是护理人员(96%)都担心新冠肺炎感染传播给家庭成员。在其他HCW中,对新冠肺炎相关死亡的恐惧最少(8%)。大多数HCW在工作场所遵守了新冠肺炎协议。交通问题是其他HCW(67%)的主要投诉,而大多数HCW(71%)认为穿脱衣服的做法影响了他们的日常工作。结论:与COVID-19相关的恐惧和污名对神经外科OT中HCW的心理社会健康产生了影响,并影响了他们的工作表现。
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引用次数: 0
Pseudoaneurysm of Mitral-Aortic Intervalvular Fibrosa – A Case Report 二尖瓣主动脉间纤维假性动脉瘤一例报告
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_14_21
C. Praveen, Sir Chhotu, Arindam Roy, N. Desai
Pseudoaneurysm of mitral-aortic intervalvular fibrosa (P-MAIVF) is a rare, well-known entity with few cases reported in the literature. We here present a case report of repair of large P-MAIVF that was successfully managed. Postoperatively patient had an uneventful course and patient was asymptomatic at 3rd month follow-up. The cause of P-MAIVF could be an atheromatous ulcer at interleaflet trigone with severely calcified aortic valve as in our case. Even if the imaging and diagnostic modalities are inconclusive, a strong suspicion should be made preoperatively in the presence of abovementioned combination for better preparedness to improve the outcome of surgery.
二尖瓣-主动脉瓣间纤维性假性动脉瘤(P-MAIVF)是一种罕见的、众所周知的实体瘤,文献中报道的病例很少。我们在这里介绍了一个成功管理的大型P-MAIVF修复的案例报告。术后患者病程平稳,随访3个月时无症状。P-MAIVF的病因可能是小叶间三角区的动脉粥样硬化性溃疡,主动脉瓣严重钙化。即使成像和诊断模式不确定,也应在术前强烈怀疑存在上述组合,以更好地准备改善手术结果。
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引用次数: 0
Genome Sequencing of SARS-CoV-2: Outcomes, Predictions, and Their Effects on Therapeutic Options 严重急性呼吸系统综合征冠状病毒2型的基因组测序:结果、预测及其对治疗方案的影响
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_75_20
Shashank M. Patil, R. Ramu
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引用次数: 3
Kikuchi Disease: Masquerading as Tubercular Cervical Lymphadenopathy 菊池病:伪装成结核性颈淋巴肿大
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_126_20
A. Garg, Prashant Choudhary, M. Chandra, Devendra Singh
Kikuchi–Fujimoto disease, also known as “histiocytic necrotizing lymphadenitis,” is a rare, benign disease that commonly affects young females. Patient usually presents with swollen lymph nodes in neck (cervical lymphadenopathy), fever, night sweats, weight loss, nausea, and vomiting. Due to the similar symptomatology, the disease is often confused with tuberculosis and lymphomas. The exact cause remains unknown with no evidence of inheritance. The diagnosis is confirmed by histopathologic examination of lymph node biopsy, which reveals necrosis (that varies considerably from one case to another), histiocytes (contains phagocytosed debris), crescentic nuclei, karyorrhexis, and plasmacytoid monocytes. The disease is self-remitting within 1 to 4 months. However, nonsteroidal anti-inflammatory drugs (NSAIDs), oral corticosteroids, and hydroxychloroquine may be used for symptomatic relief.
菊池-藤本病,也称为“组织细胞坏死性淋巴结炎”,是一种罕见的良性疾病,通常影响年轻女性。患者通常表现为颈部淋巴结肿大(颈部淋巴结病)、发烧、盗汗、体重减轻、恶心和呕吐。由于症状相似,这种疾病经常与肺结核和淋巴瘤混淆。确切的原因尚不清楚,也没有继承的证据。淋巴结活检的组织病理学检查证实了这一诊断,显示坏死(不同病例差异很大)、组织细胞(含有吞噬碎片)、新月形核、核破裂和浆细胞样单核细胞。该病在1至4个月内自行缓解。然而,非甾体抗炎药(NSAIDs)、口服皮质类固醇和羟氯喹可用于症状缓解。
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引用次数: 0
A Mixed-Method Study on Recurrent Unintentional Injuries in Children and Adolescents in a Rural Area of Delhi 德里农村地区儿童和青少年反复意外伤害的混合方法研究
Pub Date : 2021-05-01 DOI: 10.4103/mamcjms.mamcjms_2_21
B. Banerjee, Priyanka Yadav
Introduction: Unintentional injuries are largely preventable causes of death and disability in children. Understanding the extent of the problem and its contributing factors will help us in addressing them and thus prevent their occurrence to a great extent. Methodology: It is a mixed-method study, which is a part of a funded research project on unintentional childhood injuries, conducted in two villages of Delhi, on 397 children and adolescents. Quantitative data for occurrence of injuries was collected over 16 months during the period 1st September 2017-31st December 2018. Outcome variables included incidence of unintentional childhood injuries, knowledge of subjects regarding injuries and their prevention, family practices for injury prevention and treatment seeking behavior as reported by subjects, safety score regarding domestic and peridomestic environment, and danger signs within the house. Subjects with three or more incidents of unintentional injuries during the entire period of data collection were considered to have recurrent injuries and were classified as belonging to high-risk group. The qualitative part of the study included in-depth interview of subjects who suffered from recurrent injuries and their guardians in their families. Total 13 children were identified as high-risk group, of which three were below 10 years of age and hence were not interviewed. Purpose of interview was to assess the perception of each adolescent subject and his/her guardian in the family, regarding possible reasons for occurrence of recurrent injuries and the ways in which injuries can be prevented in these subjects. Results: Recurrent injuries occurred in 3.28% of total population, significantly more in male subjects. Mean age of the recurrently injured subjects and mean age of their guardians were lower than the corresponding uninjured group. Rate ratio and rate difference indicated greater vulnerability of the high-risk group of subjects. KAP scores of mothers and practice of families were significantly lower in the high-risk group than the other group. The main reasons for injury occurrence mentioned by both subjects and their guardians were that children are careless, naughty, fight with other children, and since parents do not stay at home there is no one to monitor them. Work-related injuries were also stated. Other than preventing the reasons for recurrent injuries stated by both the groups, some more measures were suggested. These were to keep the community clean as one major injury had occurred due to unclean surroundings, take help from close neighbors, particularly by working mothers of nuclear families, and elder siblings to take care of their younger siblings. Conclusion: Deeper understanding of the factors associated with unintentional injuries in specific cases provides a scope for targeted interventions. Educational programs and training of the people in the community and counseling members of the concerned families, will significantly h
引言:意外伤害在很大程度上是可预防的儿童死亡和残疾原因。了解问题的严重程度及其促成因素将有助于我们解决这些问题,从而在很大程度上防止其发生。方法:这是一项混合方法研究,是在德里的两个村庄对397名儿童和青少年进行的儿童意外伤害研究项目的一部分。2017年9月1日至2018年12月31日期间,在16个月内收集了受伤发生的定量数据。结果变量包括儿童意外伤害的发生率、受试者对伤害及其预防的了解、受试人员报告的伤害预防和寻求治疗行为的家庭实践、家庭和橄榄岩环境的安全评分以及家中的危险标志。在整个数据收集期间发生三次或三次以上非故意伤害事件的受试者被认为是复发性伤害,并被归类为高危人群。研究的定性部分包括对反复受伤的受试者及其家人的监护人进行深入访谈。共有13名儿童被确定为高危人群,其中3名年龄在10岁以下,因此没有接受采访。访谈的目的是评估每个青少年受试者及其家庭监护人对反复受伤的可能原因以及预防这些受试者受伤的方法的看法。结果:复发性损伤发生率为3.28%,男性受试者明显增多。复发性受伤受试者的平均年龄及其监护人的平均年龄低于相应的未受伤组。比率和比率差异表明高风险受试者群体的脆弱性更大。高危组的母亲和家庭实践的KAP得分显著低于其他组。受试者及其监护人提到的受伤发生的主要原因是孩子粗心大意、顽皮、与其他孩子打架,而且由于父母不呆在家里,没有人监督他们。还提到了与工作有关的伤害。除了预防两组患者反复受伤的原因外,还提出了一些更多的措施。这些措施是为了保持社区清洁,因为环境不干净造成了一次重大伤害,需要邻居的帮助,特别是核心家庭的职业母亲,以及照顾弟弟妹妹的哥哥姐姐。结论:对特定病例中与意外伤害相关的因素有更深入的了解,为有针对性的干预提供了空间。对社区人员的教育计划和培训,以及对相关家庭成员的咨询,将大大有助于预防伤害。
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引用次数: 1
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MAMC Journal of Medical Sciences
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