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An open-label randomized clinical trial to evaluate the efficacy and tolerability of flax seed nutritional supplementation in comparison with omega-3 fatty acid capsule in mild dry eye disease 一项开放标签随机临床试验,评估亚麻籽营养补充剂与omega-3脂肪酸胶囊在轻度干眼病中的疗效和耐受性
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_24_23
M. Patil, Ravindra Banakar, B. Manjunath, M. Gupta
Background: Dry eye disease (DED) is a multifactorial disease commonly encountered in ophthalmology clinics. Omega-3 fatty acid has been proved to be effective in improving the symptoms of DED. Flax seed being the richest plant source of alpha-linolenic acid can be effective in DED. Aims: To evaluate the efficacy and tolerability of flax seed supplementation in comparison with omega-3 fatty acid capsules in DED. Setting and Design: Single-center randomized open-label clinical trial done at tertiary care hospital. Subjects and Methods: Two hundred sixty-eight subjects with clinically diagnosed mild dry eye received either flax seed supplementation daily for 3 months or omega-3 fatty acid capsule once daily for 3 months. Patients were evaluated at baseline, week 4, week 8, and week 12. On each visit subjects filled ocular surface disease index (OSDI) questionnaire and underwent Schirmer test, tear break up time (TBUT) and ocular staining. Results: One hundred thirty-three patients received flax seeds and 135 received omega-3 fatty acid. Schirmer test and TBUT showed increase in scores at each visit. OSDI scores reduced at subsequent visit and were statistically significant. Two factor repeated measures analyses of variances showed no statistically significant difference between the groups in terms of OSDI scores (P = 0.018). Conclusion: Our study demonstrated a rapid response to nutritional therapy (with flax seeds and omega-3 fatty acid capsules) in alleviating the signs and symptoms of dry eyes in both the groups. Flaxseeds supplementation is comparable to omega-3 fatty acid supplementation in DED and thus forms the cost-effective treatment for dry eyes and can be considered as an adjunctive therapy for the same.
背景:干眼病是眼科临床常见的多因素疾病。Omega-3脂肪酸已被证明能有效改善DED的症状。亚麻籽是α -亚麻酸最丰富的植物来源,可有效防治DED。目的:评价亚麻籽补充剂与omega-3脂肪酸胶囊在DED中的疗效和耐受性。背景和设计:在三级医院进行的单中心随机开放标签临床试验。受试者和方法:268名临床诊断为轻度干眼症的受试者每天服用亚麻籽补充剂3个月或每天服用omega-3脂肪酸胶囊1次,连续3个月。在基线、第4周、第8周和第12周对患者进行评估。每次就诊均填写眼表疾病指数(OSDI)问卷,并进行Schirmer测验、泪液破裂时间(TBUT)和眼部染色。结果:133例患者服用亚麻籽,135例患者服用omega-3脂肪酸。Schirmer测试和TBUT在每次访问中都显示得分增加。OSDI评分在随后的访问中下降,具有统计学意义。双因素重复测量方差分析显示,两组间OSDI评分差异无统计学意义(P = 0.018)。结论:我们的研究表明,营养疗法(亚麻籽和omega-3脂肪酸胶囊)在缓解两组干眼症的体征和症状方面都有快速反应。在DED中,亚麻籽补充剂与omega-3脂肪酸补充剂相当,因此形成了具有成本效益的干眼症治疗方法,可以考虑作为一种辅助疗法。
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引用次数: 0
Trypan blue-assisted modified closed circular capsulorhexis in white cataracts: A prospective study of intraoperative and postoperative complications and visual outcome 台盼蓝辅助改良闭合环形撕囊术治疗白色白内障:术中和术后并发症及视觉效果的前瞻性研究
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_106_22
A. Joshi, V. Ramya, Sakshi Patil
A prospective study was conducted on 46 eyes of 46 patients having white cataracts, who underwent manual small incision cataract surgery and were followed up on the 1st, 7th, and 30th postoperative days. Intraoperative and postoperative complications were noted, and postoperative visual outcomes were assessed. Of 46 patients with white cataracts, mature cataract constitutes 30 (65.4%) patients, hypermature cataracts – 8 (17.3%) patients, and intumescent cataracts – 8 (17.3%) patients. The most common intraoperative complications were extension of continuous curvilinear capsulorhexis (CCC) (30.4%), Argentinian flag sign (4.34%), hyphema (4.34%), iris prolapse (4.34%), posterior capsular rupture, and vitreous loss (2.17%). The most common postoperative complications were corneal edema (36.9%), striate keratopathy (34.7%), residual cortex (13.04%), and rise in intraocular pressure (6.52%). Visual outcome on day 30 showed vision >6/9 in 67.3%, 6/12–6/9 in 17.3%, and 6/60–6/18 in 6.5%. Patients having a poor vision had moderate nonproliferative diabetic retinopathy (NPDR) with diabetic macular edema in 6.5%, age-related macular degeneration – 4.2%, severe NPDR – 2.1%, and optic atrophy – 2.1%.We conclude that modified techniques such as use of trypan blue, high-density ophthalmic viscosurgical device, mini-rhexis (two-staged CCC), and aspiration of cortical fluid using a 26G needle during CCC can decrease ocular morbidity and achieve a good postoperative visual outcome.
对46例白色白内障患者中的46只眼进行了前瞻性研究,这些患者接受了手动小切口白内障手术,并在术后第1、7和30天进行了随访。注意术中和术后并发症,并评估术后视觉效果。在46名白色白内障患者中,成熟白内障占30名(65.4%),超成熟白内障占8名(17.3%),膨胀性白内障占8例(17.3%。最常见的术中并发症是连续环形撕囊术(CCC)延长(30.4%)、阿根廷国旗征(4.34%)、前房积血(4.34%,和眼压升高(6.52%)。第30天的视觉结果显示,视力>6/9的67.3%、6/12-6的17.3%和6/60-6/18的6.5%。视力差的患者有中度非增殖性糖尿病视网膜病变(NPDR),伴有糖尿病黄斑水肿的6.5%、年龄相关性黄斑变性的4.2%、严重的NPDR的2.1%,和视神经萎缩-2.1%。我们得出的结论是,改良技术,如使用台盼蓝、高密度眼科粘性手术装置、小切口(两阶段CCC)和在CCC期间使用26G针抽吸皮层液体,可以降低眼部发病率,并获得良好的术后视觉效果。
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引用次数: 0
Effect of COVID-19 on glaucoma surgical practice in India: The challenges faced and the outcomes 2019冠状病毒病对印度青光眼手术实践的影响:面临的挑战和结果
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_112_22
A. Rao, S. Senthil
Purpose: To report the effect of COVID-19 pandemic on the glaucoma surgical practice in India. Methods: A retrospective chart review of the hospital database of cases that underwent glaucoma surgery during March 2020–September 2020 was compared to surgeries done during the same months in 2017–2018 and 2019–2021. The clinical diagnosis, demographic details, type of surgeries, clinical details (intraocular pressure [IOP] at the time of surgery and IOP at 1 month of surgery, medications, and time from advice to date of surgery) at the time of surgery, and time from surgery-last hospital visit were compared between pre-COVID and post-COVID times. Results: Of a total of 8296 glaucoma surgeries during the study period, secondary glaucoma formed the majority of type of glaucoma requiring surgery (62.5%) during COVID. Of all surgeries, trabeculectomy and bleb-related procedures were the most common surgeries during all study periods, including the COVID times (42.6% in pre-COVID, 30% in COVID 39.8% in post-COVID period, respectively). Minimally invasive glaucoma surgeries (MIGS) increased during the post-COVID period with reduced trabeculectomy procedures paralleled with an increase in the number of implant procedures during COVID time 11.7% (pre-COVID), 15% (COVID), and 10.8% (post-COVID) study periods, correlating with increase in secondary glaucoma. The surgical outcomes were similar in pre-COVID and post-COVID times. Conclusion: COVID-19 provided a fresh direction to glaucoma surgical practice toward increasing implants and MIGS in the post-COVID phase. Despite changes in the surgical trend, there were similar overall surgical outcomes in glaucoma patients undergoing surgery, this provided similar overall surgical outcome in glaucoma patients undergoing surgery during or immediately after active COVID phase compared to pre-COVID times.
目的:报道2019冠状病毒病疫情对印度青光眼手术的影响。方法:回顾性分析2020年3月至2020年9月青光眼手术病例的医院数据库,并将其与2017-2018年和2019-2021年同期进行的手术进行比较。比较患者术前和术后的临床诊断、人口学信息、手术类型、手术时的临床信息(手术时的眼压[IOP]和手术后1个月的IOP)、药物、从建议到手术日期的时间)以及手术至最后一次住院的时间。结果:在研究期间共8296例青光眼手术中,继发性青光眼在COVID期间需要手术的青光眼类型中占大多数(62.5%)。在所有手术中,小梁切除术和大泡相关手术是所有研究期间最常见的手术,包括COVID时间(分别为42.6%,30%,39.8%)。微创青光眼手术(MIGS)在COVID后期间增加,小梁切除术次数减少,同时在COVID期间植入手术次数增加11.7%(前),15%(新冠)和10.8%(后)研究期间,与继发性青光眼增加相关。术前和术后手术效果相似。结论:新冠肺炎为青光眼术后增加种植体和MIGS提供了新的手术方向。尽管手术趋势发生了变化,但接受手术的青光眼患者的总体手术结果相似,这使得在活跃的COVID期或之后立即接受手术的青光眼患者的总体手术结果与COVID前时间相似。
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引用次数: 0
Sympathetic ophthalmitis post retinal detachment surgery 视网膜脱离手术后的交感性眼炎
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_10_23
Amit S. Nene, Megha Patel, Onkar H. Pirdankar, Pratik Shenoy, Pushpanjali Badole, Smitesh Shah
We report a case of sympathetic ophthalmitis (SO) post scleral buckling and vitrectomy. A 24-year-old young male underwent retinal detachment surgery followed by silicone oil removal in the left eye. At 2-week follow-up, post oil removal, the patient was diagnosed with SO in the contralateral eye and was treated with bolus intravenous methylprednisolone and oral azathioprine which resulted in resolution of symptoms and best-corrected visual acuity improved to 20/20. Although rare, SO has a poor visual prognosis, if untreated, hence it is important to monitor the contralateral eye post vitreoretinal surgery. The presence of any inflammation in the fellow eye following vitreoretinal surgery should be treated as emergency.
我们报告了一例巩膜扣带和玻璃体切除术后的交感性眼炎。一名24岁的年轻男性接受了视网膜脱离手术,随后摘除了左眼的硅油。在2周的随访中,除油后,患者对侧眼睛被诊断为SO,并接受了甲基强的松龙静脉推注和硫唑嘌呤口服治疗,症状得到了缓解,最佳矫正视力提高到20/20。虽然罕见,但如果不治疗,SO的视觉预后较差,因此在玻璃体视网膜手术后监测对侧眼睛是很重要的。玻璃体视网膜手术后,如果同眼出现任何炎症,应视为紧急情况处理。
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引用次数: 0
A rare case of serous retinal detachment with subretinal fibrin-like material associated with pre-eclampsia, abruptio placentae, and intrauterine fetal death 一例罕见的浆液性视网膜脱离伴视网膜下纤维蛋白样物质伴先兆子痫、胎盘早剥和宫内胎儿死亡
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_124_22
C. Bindra, Parminder Bindra, Preeti Bindra, F. Khan
A 31-year-old female reported with unilateral serous retinal detachment (SRD) with subretinal fibrin-like material (SRFM) following pre-eclampsia, placental abruption, and intrauterine fetal death. The best-corrected visual acuity was 20/40 in the affected eye. Fundus angiography and optical coherence tomography revealed choroidal ischemia with SRD and SRFM which resolved gradually over 4 weeks posttreatment. The presence of SRFM with SRD could be due to intense ischemia and inflammation following transient disseminated intravascular coagulation, hypovolemia, and hypertension. Multimodal imaging modalities can help in the early diagnosis and prompt management.
一例31岁女性报告了先兆子痫、胎盘早剥和宫内胎儿死亡后单侧浆液性视网膜脱离(SRD)伴视网膜下纤维蛋白样物质(SRFM)。患眼最佳矫正视力为20/40。眼底血管造影和光学相干断层扫描显示,SRD和SRFM的脉络膜缺血在治疗后4周逐渐消退。SRFM合并SRD的存在可能是由于短暂弥散性血管内凝血、低血容量和高血压引起的强烈缺血和炎症。多模态成像模式有助于早期诊断和及时治疗。
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引用次数: 0
Evaluation of ocular surface disease due to digital usage during COVID-19 pandemic: A cross-sectional study 评估COVID-19大流行期间数字使用引起的眼表疾病:一项横断面研究
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_118_22
Seema Channabasappa, Sheetal V Girimallanavar, Balasubramanyam Aluri, Aiswarya Jose, G. Reddy
Background: This is the first study to see the effects of COVID-19 pandemic still persisting even after lockdown restrictions were relaxed on ocular health. Aims: To evaluate the presence and severity of ocular surface disease due to digital media usage in COVID-19 pandemic and to assess the severity with comorbidities such as refractive error, diabetes mellitus, and hypertension. Settings and Design: This is a cross-sectional study conducted via an online survey. Materials and Methods: An online survey was conducted among 217 individuals using ocular surface disease index (OSDI) questionnaire to assess the severity of dry eye disease due to digital media usage during the COVID-19 pandemic. Based on the OSDI score, ocular symptoms were classified into normal, mild, moderate, and severe. Statistical Analysis: Continuous variables were presented as mean ± standard deviation or median (Q1, Q3). The categorical variables were presented as frequency and percentage. Results: We included 217 respondents with 55 with mild (25.3%), 25 with moderate (11.5%) and 23 with severe dry eye (10.5%). The average number of hours spent on digital media was between 4 and 5 h before the pandemic and 6–8 h after the pandemic. The dry eye disease was also found to be associated with refractive errors, diabetes mellitus, and hypertension. Conclusion: The COVID-19 pandemic has affected the ocular health in general and had an impact on the dry eye disease in particular due to increase in the digital media usage and other associated risk factors, which has affected the work performance and efficiency was reduced.
背景:这是第一项发现新冠肺炎大流行的影响仍然持续的研究,即使在放松了对眼睛健康的封锁限制之后。目的:评估新冠肺炎大流行中数字媒体使用导致的眼表疾病的存在和严重程度,并评估屈光不正、糖尿病和高血压等合并症的严重程度。设置和设计:这是一项通过在线调查进行的横断面研究。材料和方法:使用眼表疾病指数(OSDI)问卷对217名患者进行在线调查,以评估新冠肺炎大流行期间因使用数字媒体而导致的干眼病的严重程度。根据OSDI评分,眼部症状分为正常、轻度、中度和重度。统计分析:连续变量表示为平均值±标准差或中位数(Q1,Q3)。分类变量以频率和百分比表示。结果:我们纳入了217名受访者,其中55人为轻度(25.3%),25人为中度(11.5%),23人为重度干眼症(10.5%)。在数字媒体上花费的平均小时数在大流行前4至5小时和大流行后6至8小时之间。干眼症也被发现与屈光不正、糖尿病和高血压有关。结论:新冠肺炎大流行总体上影响了眼部健康,特别是由于数字媒体使用的增加和其他相关风险因素,对干眼病产生了影响,影响了工作表现和效率。
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引用次数: 0
Impact of ocular trauma on vision-related quality of life 眼外伤对视力相关生活质量的影响
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_56_22
M. Shah, Shreya Shah, Pradeep Chandana
Introduction: Ocular trauma is a preventable cause of monocular blindness that results in morbidity and sight loss. In this study, we evaluated the impact of ocular trauma on the quality of life. Materials and Methods: In this prospective cohort study, we included all ocular trauma cases presented at Drashti Netralaya enrolled between August 2019 and August 2020. Demographic, clinical, and trauma documentation were done using a pretested online format for all the enrolled cases with specified inclusion and exclusion criteria. The life quality score was recorded using the Indian Version of Visual Function Questionnaire (VFQ). The VFQ scores were recorded before and after treatment. All data were exported into Excel sheets and analyzed with SPSS 22 using descriptive and cross-tabulation. The numerical variables were tested using one-sample t-test. P < 0.05 was considered statistically significant. Results: Our study cohort consisted of 284 patients, of which 211 (68.1%) were adults and 85 (39.9%) were children. Furthermore, 199 (70.1%) were men, and 93 (30%) were women. The mean age of the patients was 29.36 ± 17.38 years. On a comparative study, a significant difference was found between the pretreatment and posttreatment vision as well as VFQ score. Conclusion: Ocular trauma can cause sight loss and morbidity and affect the quality of life. Successful management of ocular trauma can cause a significant difference in the vision as well as quality of life.
引言:眼部创伤是导致单眼失明的一种可预防的原因,会导致发病率和视力下降。在这项研究中,我们评估了眼部创伤对生活质量的影响。材料和方法:在这项前瞻性队列研究中,我们纳入了2019年8月至2020年8月期间在Drashti Netralaya登记的所有眼部创伤病例。使用预先测试的在线格式对所有符合特定纳入和排除标准的入选病例进行人口统计学、临床和创伤记录。使用印度版视觉功能问卷(VFQ)记录生活质量评分。记录治疗前后的VFQ评分。将所有数据导出到Excel表格中,并使用SPSS 22进行描述性和交叉表分析。使用单样本t检验对数值变量进行检验。P<0.05被认为具有统计学意义。结果:我们的研究队列由284名患者组成,其中211名(68.1%)为成人,85名(39.9%)为儿童。此外,男性199人(70.1%),女性93人(30%)。患者的平均年龄为29.36±17.38岁。在一项比较研究中,发现治疗前和治疗后的视力以及VFQ评分之间存在显著差异。结论:眼外伤可导致视力下降和发病,影响生活质量。成功地处理眼外伤可以导致视力和生活质量的显著差异。
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引用次数: 0
Morning glory disc anomaly of the second cranial nerve with salt-and-pepper-like retinopathy 第二脑神经牵牛花椎间盘异常伴盐和胡椒样视网膜病变
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_121_22
M. Nada, Rohan Madan, J. Phogat, Surender Kumar
Morning glory disc anomaly (MGDA), commonly seen in females, is a congenital, funnel-shaped staphylomatous excavation of peripapillary retina and optic nerve involving the second cranial nerve head. The anomaly gets its name owing to its resemblance to a flower with the same name. We report a rare case of congenital papilla anomaly in a 21-year-old female patient who presented with diminution of vision and ocular deviation. The objective was to analyze and report functional impairment caused by the anomaly to the patient and its rare association with salt-and-pepper-like retinopathy. After thorough examination and investigations, a diagnosis of MGDA with salt-and-pepper pigmentary retinopathy associated with strabismus was made. Owing to the long-standing strabismus reported in the case, treatment included parental counseling about guarded visual prognosis and cosmetic surgical correction for strabismus.
牵牛花椎间盘异常(MGDA)常见于女性,是一种先天性漏斗状葡萄球菌性视网膜周围和视神经凹陷,累及第二颅神经头。这种异常现象之所以得名,是因为它与同名花朵相似。我们报告了一例罕见的先天性乳头异常的21岁女性患者,其表现为视力下降和眼偏斜。目的是分析和报告由异常引起的患者功能损害及其与盐和胡椒样视网膜病变的罕见关联。经过彻底的检查和调查,诊断为MGDA伴有斜视的椒盐色素性视网膜病变。由于该病例中报告的长期斜视,治疗包括父母关于保护视力预后的咨询和斜视的美容手术矫正。
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引用次数: 0
A comparative study of anxiety and depression in primary glaucoma patients 原发性青光眼患者焦虑和抑郁的比较研究
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_122_22
Enakshi Bose, S. Majumdar, S. Sarkar
Background: Glaucoma is one of the most common causes of irreversible blindness. Neuroinflammation has a role in the pathogenesis of glaucoma and this inflammatory activity has been found in the brains of patients with depression. The need for prolonged treatment and follow-up and the fear of permanent loss of vision in glaucoma imposes economic and psychological burden. Aims: This study aims to assess the magnitude of anxiety and depression in patients with and without primary glaucoma and compare. Setting and Design: Cross-sectional observational study carried out in a tertiary care institute. Materials and Methods: Sixty-five patients with primary glaucoma (primary open-angle glaucoma, primary angle closure glaucoma as cases) and 65 without glaucoma (controls) were selected after institutional ethics committee approval and consent for participation. Detailed ocular examination for glaucoma diagnosis and screening by Patient Health Questionnaire 9 (PHQ-9) Depression scale and Generalized Anxiety Disorder 7 (GAD-7) anxiety scale done for the assessment of depression and anxiety, respectively. Logistic regression analysis with anxiety, depression, and glaucoma was conducted and adjusted for sociodemographic factors. Results: Mean PHQ (for depression) score (19.3231 ± 5.3564) and mean GAD-7 (for anxiety) score (12.1231 ± 4.1098) were significantly higher in glaucoma patients compared to controls (P < 0.0001). The association between PHQ scale score and GAD-7 score with the type of glaucoma was not significant (P = 0.983). Likewise, gender and the magnitude of depression and anxiety (measured by PHQ-9 scale and GAD-7 scale) were not statistically significant. Conclusion: Moderate and severe anxiety and depression were significantly associated with primary glaucoma when compared to controls.
背景:青光眼是不可逆失明最常见的原因之一。神经炎症在青光眼的发病机制中起作用,并且在抑郁症患者的大脑中发现了这种炎症活动。青光眼患者需要长时间的治疗和随访,并且担心永久丧失视力,这给患者带来了经济和心理上的负担。目的:本研究旨在评估原发性青光眼患者和非原发性青光眼患者的焦虑和抑郁程度并进行比较。背景和设计:横断面观察研究在三级保健机构进行。材料与方法:经机构伦理委员会批准并同意后,选择原发性青光眼患者65例(以原发性开角型青光眼、原发性闭角型青光眼为例),非青光眼患者65例(对照组)。采用患者健康问卷9 (PHQ-9)抑郁量表和广泛性焦虑障碍7 (GAD-7)焦虑量表分别评估抑郁和焦虑,进行青光眼诊断和筛查的详细眼部检查。对焦虑、抑郁和青光眼进行Logistic回归分析,并根据社会人口因素进行调整。结果:青光眼患者平均PHQ(抑郁)评分(19.3231±5.3564)和平均GAD-7(焦虑)评分(12.1231±4.1098)明显高于对照组(P < 0.0001)。PHQ评分和GAD-7评分与青光眼类型的相关性无统计学意义(P = 0.983)。同样,性别和抑郁和焦虑程度(用PHQ-9量表和GAD-7量表测量)无统计学意义。结论:与对照组相比,中度和重度焦虑和抑郁与原发性青光眼显著相关。
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引用次数: 0
Modernizing ophthalmology: The transformative role of artificial intelligence 眼科现代化:人工智能的变革作用
Pub Date : 2023-05-01 DOI: 10.4103/jcor.jcor_49_23
R. Joshi
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引用次数: 0
期刊
Journal of Clinical Ophthalmology and Research
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