O. Oluba, C. Onyeneke, G. Ojieh, G. Eidangbe, R. Orole
The effects of palm oil supplementation (5%) to a cholesterol-based (5%) diet on lipid peroxidation, and on glutathione peroxidase activity in rat's liver were examined. The rate of lipid peroxidation in the liver was determined in vitro by the thiobarbituric acid (TBA) test, and by conjugated diene measurement. Palm oil supplementation significantly reduced (p<0.05) the rate of lipid peroxidation in the liver of rats fed 5% cholesterol, compared to the rate observed in the liver of rats fed 5% cholesterol diet without palm oil. On the other hand glutathione peroxidase activity was significantly increased (p<0.05) in the liver of rats fed palm oil supplemented diet compared with those fed cholesterol diet without palm oil. The study suggests that palm oil feeding could be a veritable nutritional tool in the prevention of lipid-induced oxidative damage as usually observed in atheromatous plaque.
{"title":"Effects of Palm Oil Supplementation on Lipid Peroxidation and Glutathione Peroxidase Activity in Cholesterol – Fed Rats","authors":"O. Oluba, C. Onyeneke, G. Ojieh, G. Eidangbe, R. Orole","doi":"10.5580/2620","DOIUrl":"https://doi.org/10.5580/2620","url":null,"abstract":"The effects of palm oil supplementation (5%) to a cholesterol-based (5%) diet on lipid peroxidation, and on glutathione peroxidase activity in rat's liver were examined. The rate of lipid peroxidation in the liver was determined in vitro by the thiobarbituric acid (TBA) test, and by conjugated diene measurement. Palm oil supplementation significantly reduced (p<0.05) the rate of lipid peroxidation in the liver of rats fed 5% cholesterol, compared to the rate observed in the liver of rats fed 5% cholesterol diet without palm oil. On the other hand glutathione peroxidase activity was significantly increased (p<0.05) in the liver of rats fed palm oil supplemented diet compared with those fed cholesterol diet without palm oil. The study suggests that palm oil feeding could be a veritable nutritional tool in the prevention of lipid-induced oxidative damage as usually observed in atheromatous plaque.","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131340390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The microanatomy of the ascending aorta has hemodynamic implications. This study, therefore, aim to make a comparative analysis of the microanatomy of the ascending aorta in pangolin and rat since the different ways of life of each mammal can influence the rate of blood flow through the ascending aorta at an given period. Following sacrifice of animals, aortae recovered from pangolin (n=6), and rat (n=5) were processed for histological studies. Tissues were stained with haematoxylin and eosin, and orcein. The results of this investigation revealed differences in the microanatomy of the ascending aorta between pangolin and rat. The differences relate essentially to thickness of vascular layers, elastic fiber distribution, nuclear shapes, and perinuclear spaces. These differences correlate with animal size and perhaps modes of life.
{"title":"Microanatomical Differences between Pangolin (Manis tricuspis) and Rat Ascending Aortae","authors":"L. Medubi, O. R. Jimoh, O. Ghazal, G. Adefolaju","doi":"10.5580/257f","DOIUrl":"https://doi.org/10.5580/257f","url":null,"abstract":"The microanatomy of the ascending aorta has hemodynamic implications. This study, therefore, aim to make a comparative analysis of the microanatomy of the ascending aorta in pangolin and rat since the different ways of life of each mammal can influence the rate of blood flow through the ascending aorta at an given period. Following sacrifice of animals, aortae recovered from pangolin (n=6), and rat (n=5) were processed for histological studies. Tissues were stained with haematoxylin and eosin, and orcein. The results of this investigation revealed differences in the microanatomy of the ascending aorta between pangolin and rat. The differences relate essentially to thickness of vascular layers, elastic fiber distribution, nuclear shapes, and perinuclear spaces. These differences correlate with animal size and perhaps modes of life.","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132516877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Traumatic pulmonary pseudocyst is an infrequent complication of blunt chest trauma. A 40 year-old male patient was hospitalized after a blunt chest trauma. Twenty hours after the accident, two air filled cysts with a surrounding consolidation area, in the upper lobe of left lung were detected radiologically. The patient did not give any previous lung disease history. The cysts of the lung were firstly accepted as traumatic pulmonary pseudocyst and followed-up with conservative management. During the follow-up, pseudocysts began to shrink after the 17th day and compeletely resolved on the 51st day of the accident. This rare entity is most often seen in children and young adults. Traumatic pulmonary pseudocysts do not include epithelium or bronchial wall elements as it is in a true cyst. The treatment is generally conservative since they usually resolve spontaneously. Surgery should be considered in case of failed conservative treatment and development of complications.
{"title":"Rare Complication Of Blunt Chest Trauma: Pulmonary Pseudocyst","authors":"S. Gezer, Sema Y ld z, Ali K l çgün","doi":"10.5580/c3a","DOIUrl":"https://doi.org/10.5580/c3a","url":null,"abstract":"Traumatic pulmonary pseudocyst is an infrequent complication of blunt chest trauma. A 40 year-old male patient was hospitalized after a blunt chest trauma. Twenty hours after the accident, two air filled cysts with a surrounding consolidation area, in the upper lobe of left lung were detected radiologically. The patient did not give any previous lung disease history. The cysts of the lung were firstly accepted as traumatic pulmonary pseudocyst and followed-up with conservative management. During the follow-up, pseudocysts began to shrink after the 17th day and compeletely resolved on the 51st day of the accident. This rare entity is most often seen in children and young adults. Traumatic pulmonary pseudocysts do not include epithelium or bronchial wall elements as it is in a true cyst. The treatment is generally conservative since they usually resolve spontaneously. Surgery should be considered in case of failed conservative treatment and development of complications.","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130769490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niemann-Pick C1 �like 1 (NPC1L1) protein, a newly identified sterol influx transporter, located at the apical membrane of the enterocyte, which may actively facilitate the uptake of cholesterol by promoting the passage of sterols across the brush border membrane of the enterocyte. It effects intestinal cholesterol absorption and intracellular transport and as such is an integral part of complex process of cholesterol homeostasis. The study of population data for the distribution of these SNPs of NPC1L1 has lead to the identification of six nsSNPs (non-synonymous single nucleotide polymorphism). The in vitro analysis using the software MuPro and StructureSNP shows that nsSNP M510I (rs1468384), which involves A!iG base pair change leads to decrease in the stability of the protein. A reproducible and a cost-effective PCR-RFLP based assay was developed to screen for the SNP distribution amongst the North Western Indian population as a test case. This SNP has been studied in Caucasian, Asian and African American populations. Till date, no data is available on Indian population. The allele distribution in Indian Population differs significantly from that of other populations. Moreover on investigating the effect of this nsSNP on the plasma lipid levels in the general population we found a profound association of this nsSNP with higher ranges of plasma lipid levels.
Niemann-Pick C1样1 (NPC1L1)蛋白是一种新发现的固醇内流转运蛋白，位于肠细胞的顶端膜，它可能通过促进固醇穿过肠细胞的刷状边界膜，积极促进胆固醇的摄取。它影响肠道胆固醇吸收和细胞内运输，因此是胆固醇稳态复杂过程的一个组成部分。通过对NPC1L1 snp分布的群体数据研究，鉴定出6个非同义单核苷酸多态性(non-synonymous single nucleotide polymorphism, nssnp)。利用MuPro软件和StructureSNP进行体外分析，发现nsSNP M510I (rs1468384)涉及A!iG碱基对的改变导致蛋白稳定性下降。开发了一种可重复且具有成本效益的基于PCR-RFLP的检测方法，以筛选西北印度人群中的SNP分布作为测试案例。这种SNP已经在白种人、亚洲人和非裔美国人中进行了研究。到目前为止，没有关于印度人口的数据。印度人群的等位基因分布与其他人群有显著差异。此外，在调查该nsSNP对普通人群血脂水平的影响时，我们发现该nsSNP与较高的血脂水平范围有深刻的关联。
{"title":"Analysis of nsSNP rs1468384 of NPC1L1 and its association with plasma cholesterol levels in general population","authors":"P. Balgir, Divya Khanna, Gurlovleen Kaur","doi":"10.5580/81c","DOIUrl":"https://doi.org/10.5580/81c","url":null,"abstract":"Niemann-Pick C1 �like 1 (NPC1L1) protein, a newly identified sterol influx transporter, located at the apical membrane of the enterocyte, which may actively facilitate the uptake of cholesterol by promoting the passage of sterols across the brush border membrane of the enterocyte. It effects intestinal cholesterol absorption and intracellular transport and as such is an integral part of complex process of cholesterol homeostasis. The study of population data for the distribution of these SNPs of NPC1L1 has lead to the identification of six nsSNPs (non-synonymous single nucleotide polymorphism). The in vitro analysis using the software MuPro and StructureSNP shows that nsSNP M510I (rs1468384), which involves A!iG base pair change leads to decrease in the stability of the protein. A reproducible and a cost-effective PCR-RFLP based assay was developed to screen for the SNP distribution amongst the North Western Indian population as a test case. This SNP has been studied in Caucasian, Asian and African American populations. Till date, no data is available on Indian population. The allele distribution in Indian Population differs significantly from that of other populations. Moreover on investigating the effect of this nsSNP on the plasma lipid levels in the general population we found a profound association of this nsSNP with higher ranges of plasma lipid levels.","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133016094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Özbek, U. Yetkin, N. Postac, Tevfik Güne, A. Durmu, A. Gürbüz
Surgery is often needed for cases with multiple valve involvement where different therapeutic options can be used for the different valves. The decision to perform valve repair depends more on the extent of the etiology. We describe a case of repair of three valves in a single operation. Surgical techniques are evolving continuously and making it possible to treat lesions that we previously thought were beyond repair.
{"title":"Repair of Three Valves in a Single Operation","authors":"C. Özbek, U. Yetkin, N. Postac, Tevfik Güne, A. Durmu, A. Gürbüz","doi":"10.5580/1d77","DOIUrl":"https://doi.org/10.5580/1d77","url":null,"abstract":"Surgery is often needed for cases with multiple valve involvement where different therapeutic options can be used for the different valves. The decision to perform valve repair depends more on the extent of the etiology. We describe a case of repair of three valves in a single operation. Surgical techniques are evolving continuously and making it possible to treat lesions that we previously thought were beyond repair.","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134604033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suresh Kumar, Ramakant, A. Rai, Sunil Kumar, Surendra Kumar, J. Kumar, R. Garg
Introduction: of all causes of traumatic injuries, thoracic trauma is considered to be an attributed to thoracic injury. The favoured management for thoracic trauma till date is prolonged ICD insertion and to resuscitate patient to maintain hemodynamic parameter or to go for open thoracostomy in unstable patients as per indication. Video Assisted Thoracoscopic Surgery is being increasingly utilized as diagnostic as well as theraupeautic modality in management of stable patient with thoracic injury. This study was designed to evaluate the efficacy of VATS in the management of thoracic trauma in term of pain, dose of analgesic used, duration of hospital stay, restoration of pulmonary function and complication rate. Method: The study was conducted on 70 patients of thoracic injury (Blunt or Penetrating) who presented in Trauma Center of CSMMU (formerly K.G.M.U.), Lcuknow,India.. The patients were matched for Age and Sex and randomly, and are assigned in
{"title":"evaluation of thoracoscopic management of thoracic trauma","authors":"Suresh Kumar, Ramakant, A. Rai, Sunil Kumar, Surendra Kumar, J. Kumar, R. Garg","doi":"10.5580/1077","DOIUrl":"https://doi.org/10.5580/1077","url":null,"abstract":"Introduction: of all causes of traumatic injuries, thoracic trauma is considered to be an attributed to thoracic injury. The favoured management for thoracic trauma till date is prolonged ICD insertion and to resuscitate patient to maintain hemodynamic parameter or to go for open thoracostomy in unstable patients as per indication. Video Assisted Thoracoscopic Surgery is being increasingly utilized as diagnostic as well as theraupeautic modality in management of stable patient with thoracic injury. This study was designed to evaluate the efficacy of VATS in the management of thoracic trauma in term of pain, dose of analgesic used, duration of hospital stay, restoration of pulmonary function and complication rate. Method: The study was conducted on 70 patients of thoracic injury (Blunt or Penetrating) who presented in Trauma Center of CSMMU (formerly K.G.M.U.), Lcuknow,India.. The patients were matched for Age and Sex and randomly, and are assigned in","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134210223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Five percent of patients require re-exploration during early postoperative period after open heart surgery. The first cause for early mediastinal re-exploration after open heart surgery is the bleeding. In this review report we evaluated the major risk factors, the decision making for revision and the frequent complications after revision for bleeding under light of the literature. To reduce the risk for bleeding and blood transfusion rates, we recommend that discontinuation of the drugs affecting platelet functions, achievement of shortest CPB time possible, recurrent effective hemostasis before closure and faster elimination of hypothermia after arrival into the intensive care unit.
{"title":"Revision for postoperative bleeding: timing and decision making","authors":"U. Yetkin, smail Yürekli, A. Gürbüz","doi":"10.5580/16c6","DOIUrl":"https://doi.org/10.5580/16c6","url":null,"abstract":"Five percent of patients require re-exploration during early postoperative period after open heart surgery. The first cause for early mediastinal re-exploration after open heart surgery is the bleeding. In this review report we evaluated the major risk factors, the decision making for revision and the frequent complications after revision for bleeding under light of the literature. To reduce the risk for bleeding and blood transfusion rates, we recommend that discontinuation of the drugs affecting platelet functions, achievement of shortest CPB time possible, recurrent effective hemostasis before closure and faster elimination of hypothermia after arrival into the intensive care unit.","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124836211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The association between hypertension and dyslipidaemia is well established and both may add up to increase patients’ susceptibility to the development of coronary heart disease. Methods: Lipid profiles were studied in one hundred and fifty (150) hypertensive patients aged 30-59 years and thirty (30) ageand socio-economically matched normotensive controls using standard laboratory techniques. Results: Of the 150 hypertensive patients, 54% (n = 69) were females with majority (45.7%) in the age range 50-59 years while majority (53.6%) of hypertensive males were in the age group 40-49 years. Hypertensive patients have significantly higher lipid profile except for HDL-Cholesterol, which did not show any significant difference in the two groups. Among the hypertensive patients, total cholesterol was positively correlated with triglyceride (0.399,p < 0.05), LDL-cholesterol (r = 0.609,p < 0.05) and HDLcholesterol (r = 0.866,p < 0.05) and HDL-C positively correlated with LDL-C (r = 0.218,p < 0.05). In normotensive patients however, LDL-cholesterol was negatively correlated with triglyceride (r = -0.409,p < 0.05) while total cholesterol was positively correlated with LDL-cholesterol (r = 0.876,p < 0.05). Conclusion: Hypertensive Nigerians have significantly elevated plasma total cholesterol, Triglyceride and LDL-C but comparable HDL-C with normotensives. The clinical implications of elevated HDL-C in hypercholesterolemic hypertensive Nigerians are unclear.
{"title":"Plasma Lipid Profiles in Hypertensive Nigerians","authors":"J. Idemudia, E. Ugwuja","doi":"10.5580/117f","DOIUrl":"https://doi.org/10.5580/117f","url":null,"abstract":"Background: The association between hypertension and dyslipidaemia is well established and both may add up to increase patients’ susceptibility to the development of coronary heart disease. Methods: Lipid profiles were studied in one hundred and fifty (150) hypertensive patients aged 30-59 years and thirty (30) ageand socio-economically matched normotensive controls using standard laboratory techniques. Results: Of the 150 hypertensive patients, 54% (n = 69) were females with majority (45.7%) in the age range 50-59 years while majority (53.6%) of hypertensive males were in the age group 40-49 years. Hypertensive patients have significantly higher lipid profile except for HDL-Cholesterol, which did not show any significant difference in the two groups. Among the hypertensive patients, total cholesterol was positively correlated with triglyceride (0.399,p < 0.05), LDL-cholesterol (r = 0.609,p < 0.05) and HDLcholesterol (r = 0.866,p < 0.05) and HDL-C positively correlated with LDL-C (r = 0.218,p < 0.05). In normotensive patients however, LDL-cholesterol was negatively correlated with triglyceride (r = -0.409,p < 0.05) while total cholesterol was positively correlated with LDL-cholesterol (r = 0.876,p < 0.05). Conclusion: Hypertensive Nigerians have significantly elevated plasma total cholesterol, Triglyceride and LDL-C but comparable HDL-C with normotensives. The clinical implications of elevated HDL-C in hypercholesterolemic hypertensive Nigerians are unclear.","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126671031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U. Yetkin, C. Özbek, M. Bademci, smail Yürekli, Murat Ye il, A. Gürbüz
Coiling of the artery is a rare morphologic entity.We describe a case of kinking of left internal mammary artery graft exhibiting as false coiling entity INTRODUCTION Coiling (or looping) of the artery is a rare morphologic entity, most frequently described in the internal carotid artery. In other arteries, coiling is rarely reported because it remains asymptomatic and without clinical relevance unless inadvertently injured, as for diagnostic or monitoring purposes(1). The internal mammary artery is the most frequently used bypass conduit for the left anterior descending coronary artery in patients treated with bypass surgery, with excellent long-term patency rates. However, the mammary artery may also be affected by functionally significant stenoses. Most stenoses of the mammary artery are secondary to the surgical procedure at the anastomosis site, but atherosclerotic lesions may also develop(2). CASE PRESENTATION Our case was a 43-year-old male. His past medical history was significant for 3-vessel CABG and concomitant mitral ring annuloplasty at a different health facility 4 years ago. He was suffering from chest pain for 3 months. His coronary angiogram revealed stenoses in saphenous venous graft to the right coronary artery, in the native circumflex and left anterior descending arteries at postanastomotic segments. Percutaneous approach was planned for treatment. But during rehospitalization period, he suffered from fever and investigations identified a subacute bacterial endocarditis including the mitral valve (moderate mitral regurgitation and a vegetative mass of 1.9x0.9 cm on atrial face of mitral anterior leaflet). He was then referred to our clinic for reCABG and mitral valve exploration. His coronary angiogram showed a lesion of left internal mammarian artery graft consistent with coiling at right anterior oblique position (Figures 1&2).
{"title":"Kinking of left internal mammary artery graft exhibiting as false coiling entity","authors":"U. Yetkin, C. Özbek, M. Bademci, smail Yürekli, Murat Ye il, A. Gürbüz","doi":"10.5580/1222","DOIUrl":"https://doi.org/10.5580/1222","url":null,"abstract":"Coiling of the artery is a rare morphologic entity.We describe a case of kinking of left internal mammary artery graft exhibiting as false coiling entity INTRODUCTION Coiling (or looping) of the artery is a rare morphologic entity, most frequently described in the internal carotid artery. In other arteries, coiling is rarely reported because it remains asymptomatic and without clinical relevance unless inadvertently injured, as for diagnostic or monitoring purposes(1). The internal mammary artery is the most frequently used bypass conduit for the left anterior descending coronary artery in patients treated with bypass surgery, with excellent long-term patency rates. However, the mammary artery may also be affected by functionally significant stenoses. Most stenoses of the mammary artery are secondary to the surgical procedure at the anastomosis site, but atherosclerotic lesions may also develop(2). CASE PRESENTATION Our case was a 43-year-old male. His past medical history was significant for 3-vessel CABG and concomitant mitral ring annuloplasty at a different health facility 4 years ago. He was suffering from chest pain for 3 months. His coronary angiogram revealed stenoses in saphenous venous graft to the right coronary artery, in the native circumflex and left anterior descending arteries at postanastomotic segments. Percutaneous approach was planned for treatment. But during rehospitalization period, he suffered from fever and investigations identified a subacute bacterial endocarditis including the mitral valve (moderate mitral regurgitation and a vegetative mass of 1.9x0.9 cm on atrial face of mitral anterior leaflet). He was then referred to our clinic for reCABG and mitral valve exploration. His coronary angiogram showed a lesion of left internal mammarian artery graft consistent with coiling at right anterior oblique position (Figures 1&2).","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129442664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The pharmaceutical Regadenoson (Lexiscan TM ) Produced by Astellas Inc. Is currently in use as a pharmacological stress agent for myocardial perfusion imaging within the field of Nuclear Cardiology. Regadenoson is a selective A 2A adenosine receptor agonist, and also has a low affinity for adenosine receptors which cause bronchoconstriction in patients with reactive airways mediated via A 2B and A3 adenosine receptors. In a study of 42 patients with mild to moderate asthma and/or moderate to severe COPD who had a positive adenosine monophosphate test, Regadenoson proved to be relatively safe and well tolerated by most patients (90%). 8 Regadenoson is a low affinity agonist (Ki "H 1.3 µM) for the A2A adenosine receptor, with at least 10-fold lower affinity for the A1 adenosine receptor (Ki > 16.5 µM), and weak, if any, affinity for the A2B and A3 adenosine receptors. 2,9 Activation of the A2A adenosine receptor by regadenoson produces coronary vasodilation 8 and increases coronary blood flow (CBF). It
药物Regadenoson (Lexiscan TM)由安斯泰来公司生产。目前在核心脏病学领域被用作心肌灌注成像的药理学应激剂。Regadenoson是一种选择性的a2a腺苷受体激动剂，对通过a2b和A3腺苷受体介导的反应性气道患者引起支气管收缩的腺苷受体也具有低亲和力。在一项42例轻至中度哮喘和/或中至重度COPD患者的研究中，大多数患者(90%)的单磷酸腺苷试验阳性，Regadenoson被证明是相对安全且耐受性良好的。Regadenoson是A2A腺苷受体的低亲和力激动剂(Ki ' H 1.3µM)，对A1腺苷受体的亲和力至少低10倍(Ki > 16.5µM)，对A2B和A3腺苷受体的亲和力较弱(如果有的话)。regadenoson激活A2A腺苷受体可产生冠状动脉血管舒张8并增加冠状动脉血流量(CBF)。它
{"title":"Effects of adenosine A2A receptor low affinity agonist Regadenoson in patients with obstructive pulmonary disease, at risk for adenosine-induced bronchoconstriction mediated via A2B and/or A3 adenosine receptors.","authors":"Stefan H. Meyering, H. Lomas","doi":"10.5580/ff4","DOIUrl":"https://doi.org/10.5580/ff4","url":null,"abstract":"The pharmaceutical Regadenoson (Lexiscan TM ) Produced by Astellas Inc. Is currently in use as a pharmacological stress agent for myocardial perfusion imaging within the field of Nuclear Cardiology. Regadenoson is a selective A 2A adenosine receptor agonist, and also has a low affinity for adenosine receptors which cause bronchoconstriction in patients with reactive airways mediated via A 2B and A3 adenosine receptors. In a study of 42 patients with mild to moderate asthma and/or moderate to severe COPD who had a positive adenosine monophosphate test, Regadenoson proved to be relatively safe and well tolerated by most patients (90%). 8 Regadenoson is a low affinity agonist (Ki \"H 1.3 µM) for the A2A adenosine receptor, with at least 10-fold lower affinity for the A1 adenosine receptor (Ki > 16.5 µM), and weak, if any, affinity for the A2B and A3 adenosine receptors. 2,9 Activation of the A2A adenosine receptor by regadenoson produces coronary vasodilation 8 and increases coronary blood flow (CBF). It","PeriodicalId":330833,"journal":{"name":"The Internet Journal of Thoracic and Cardiovascular Surgery","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121674832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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