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Pancreaticojejunostomy versus pancreaticogastrostomy after pancreaticoduodenectomy: A review article and meta-analysis of randomized controlled trials 胰十二指肠切除术后胰空肠造口与胰胃造口:一篇综述文章和随机对照试验的荟萃分析
Pub Date : 1900-01-01 DOI: 10.4103/ijssr.ijssr_8_18
N. Shahzad, T. Chawla, S. Begum, Fareed Shaikh
Pancreatic fistula is one of the most feared complications after pancreaticoduodenectomy (PD). Results of randomized controlled trials comparing pancreaticogastric anastomosis with pancreaticojejunal anastomosis are not consistent. Furthermore, soft texture of pancreas is an established risk factor for postoperative pancreatic fistula (POPF). There has been no meta-analysis to date to compare pancreaticogastrostomy versus pancreaticojejunostomy in patients with intraoperative soft texture of pancreas. Hence, our primary objective was to determine the role of pancreaticogastrostomy compared to pancreaticojejunostomy after PD in prevention of POPF, especially in patients with soft pancreatic texture. We conducted meta-analysis of randomized controlled trials that had compared pancreaticojejunal anastomosis with pancreaticogastric anastomosis after PD, and pancreatic fistula was among the outcome variables. Ten randomized controlled trials were included in the meta-analysis which comprised of a total of 1629 patients, of which 803 underwent pancreaticojejunostomy, whereas 826 were in the pancreaticogastrostomy group. There was no difference in clinically relevant POPF (CR-POPF) rate in pancreaticojejunostomy versus pancreaticogastrostomy (19.8% vs. 12.8%, P = 0.09) group. POPF rate in patients with soft pancreas was significantly more in pancreaticojejunostomy group as compared to pancreaticogastrostomy group (25.4% vs. 17.3%, odds ratio = 1.71, 95% confidence interval = 1.15–2.53, P = 0.008). Although there is no difference in pancreaticogastrostomy as compared to pancreaticojejunostomy after PD to prevent CR POPF, in a subgroup of high-risk patients with soft pancreatic texture pancreaticogastrostomy has favorable results.
胰瘘是胰十二指肠切除术(PD)后最可怕的并发症之一。比较胰胃吻合术和胰空肠吻合术的随机对照试验结果不一致。此外,胰腺柔软的质地是术后胰瘘(POPF)的危险因素。迄今为止还没有meta分析比较术中胰腺软质患者的胰胃造口术和胰空肠造口术。因此,我们的主要目的是确定胰胃造口术与胰空肠造口术在PD后预防POPF的作用,特别是在胰腺质地柔软的患者中。我们对比较胰空肠吻合术和胰胃吻合术的随机对照试验进行了荟萃分析,胰瘘是结果变量之一。meta分析纳入10项随机对照试验,共1629例患者,其中803例行胰空肠造口术,826例行胰胃造口术。胰空肠吻合术组与胰胃吻合术组临床相关POPF (CR-POPF)率差异无统计学意义(19.8% vs 12.8%, P = 0.09)。软胰组的POPF率明显高于胰胃造口组(25.4% vs. 17.3%,优势比为1.71,95%可信区间为1.15 ~ 2.53,P = 0.008)。虽然PD后胰胃造口术与胰空肠造口术在预防CR POPF方面没有差异,但在胰腺质地柔软的高危患者亚组中,胰胃造口术的效果较好。
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引用次数: 1
Prevention and management of hard- and soft-tissue complication in patient undergoing radiotherapy and chemotherapy: Literature review 放化疗患者硬、软组织并发症的预防与处理:文献综述
Pub Date : 1900-01-01 DOI: 10.4103/ijssr.ijssr_7_18
M. Gul, S. Badar, Robia Ghafoor
Head and neck cancer is among the leading causes of death globally. Its treatment includes surgical resection, radiotherapy, chemotherapy, or the combination of these therapies depending on the extent of disease. Radiotherapy and chemotherapy have a pivotal role in minimizing the morbidity and mortality; however, they also bring about many adverse effects. Both hard and soft tissues of the oral cavity are affected by these therapies ranging from oral mucositis to osteoradionecrosis of jaw thus affecting the quality of life of patients. Prevention and timely management of these complications are essential for better treatment outcomes. The present literature review, therefore, focuses on the prevention and management of hard- and soft-tissue complications associated with patients undergoing radiotherapy and chemotherapy. Comprehensive oral and dental examination of the patient should be performed and all the potential sources of infection should be electively treated appropriately before initiation of the radiotherapy and chemotherapy to reduce the risk of complications associated with the cancer treatment. Management of complication that arises during radiation and chemotherapy is also essential which requires thorough knowledge and skills. Mutual participation of oncology team and dental surgeon is the key to reduce these complications.
头颈癌是全球死亡的主要原因之一。其治疗包括手术切除,放疗,化疗,或根据疾病的程度结合这些疗法。放疗和化疗在降低发病率和死亡率方面起着关键作用;然而,它们也带来了许多不利影响。从口腔黏膜炎到颌骨的放射性骨坏死,这些治疗会影响口腔的软硬组织,从而影响患者的生活质量。预防和及时处理这些并发症对于取得更好的治疗效果至关重要。因此,目前的文献综述主要集中在放疗和化疗患者相关的软组织和硬组织并发症的预防和处理。在放疗和化疗开始前,应对患者进行全面的口腔和牙科检查,并对所有潜在的感染源进行适当的选择性治疗,以减少与癌症治疗相关的并发症的风险。在放疗和化疗期间出现的并发症的管理也是必不可少的,这需要全面的知识和技能。肿瘤团队和口腔外科医生的共同参与是减少这些并发症的关键。
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引用次数: 1
Perspectives on large bowel obstruction 大肠梗阻的观点
Pub Date : 1900-01-01 DOI: 10.4103/2468-7332.200556
E. Weledji
Large bowel obstruction (LBO) is a serious and costly medical condition, indicating often emergency surgery. The main clinical issue is to determine whether the obstruction affects the small bowel or the colon since the causes and treatments are different. Delay in operative intervention may lead to an unnecessary bowel resection, increased risk of perforation, and overall worsening of patient morbidity and mortality. With the advent of colonic endoluminal stent, the treatment of distal colonic obstruction should be individually tailored to each patient. This article discussed LBO and emphasized the importance of history taking, examination, and basic imaging in the early diagnosis of its cause, thus facilitating appropriate management.
大肠梗阻(LBO)是一种严重且昂贵的医疗状况,通常需要紧急手术。由于病因和治疗方法不同,主要的临床问题是确定梗阻是影响小肠还是结肠。手术干预的延迟可能导致不必要的肠切除术,增加穿孔的风险,以及患者发病率和死亡率的总体恶化。随着结肠腔内支架的出现,结肠远端梗阻的治疗应因人而异。本文讨论了杠杆收购,并强调了历史,检查和基本影像学在早期诊断其原因,从而促进适当的管理的重要性。
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引用次数: 1
Stress management in a medical career 医学生涯中的压力管理
Pub Date : 1900-01-01 DOI: 10.4103/ijssr.ijssr_12_17
M. Borrelli, R. Farwana, R. Agha
Stress is both the psychological and physical experienced when an individual perceives their resources as insufficient to cope with the demands of a situation. A medical career can be stressful. The work of health-care professionals involves taking responsibility for other individuals' lives and mistakes can have detrimental consequences. Work can involve long hours, night shifts, and high-risk situations. High levels of stress among doctors contribute to job dissatisfaction, emotional burnout, and clinical depression, and can undermine the achievement of goals, both for individuals and for organizations. Stress management is therefore a fundamental skill for all medical professionals. This article discusses strategies for managing stress, starting with self-analysis and outlining two main stress management techniques that can be taken at an individual level.
压力是指当一个人感觉到自己的资源不足以应付某种情况的需求时,他所经历的心理和生理两方面的压力。医生的工作压力很大。保健专业人员的工作涉及对他人的生命负责,错误可能产生有害后果。工作可能包括长时间、夜班和高风险的情况。医生的高水平压力会导致工作不满、情绪倦怠和临床抑郁,并可能破坏个人和组织目标的实现。因此,压力管理是所有医疗专业人员的基本技能。这篇文章讨论了管理压力的策略,从自我分析开始,概述了两个主要的压力管理技巧,可以在个人层面上采取。
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引用次数: 0
Hepatocellular adenoma: Review of contemporary diagnostic and therapeutic options 肝细胞腺瘤:当代诊断和治疗方案综述
Pub Date : 1900-01-01 DOI: 10.4103/ijssr.ijssr_4_18
S. Begum, M. Khan
Hepatocellular adenoma (HCA) is a rare benign lesion most often seen in young women with a history of oral contraceptive use. It is typically a solitary lesion located in the right hepatic lobe although multiple lesions have been reported. Diagnosis of HCA is important for prompt treatment because of risk of hemorrhage and malignant transformation. Adenomas are not specifically diagnosed at ultrasonography, and further evaluation with computerized tomography and magnetic resonance imaging is required to differentiate from other hepatic lesions such as focal nodular hyperplasia. The gold standard for diagnosis is excision biopsy. Better understanding of clinical history and imaging appearance is important to avoid misdiagnosis and facilitate effective treatment.
肝细胞腺瘤(HCA)是一种罕见的良性病变,最常见于有口服避孕药史的年轻女性。它通常是位于右肝叶的单发病变,尽管有多处病变的报道。由于出血和恶性转化的风险,HCA的诊断对及时治疗很重要。超声检查不能明确诊断腺瘤,需要通过计算机断层扫描和磁共振成像进一步评估,以与其他肝脏病变(如局灶性结节性增生)区分。诊断的金标准是切除活检。更好地了解临床病史和影像学表现对避免误诊和促进有效治疗至关重要。
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引用次数: 2
Awake craniotomy in developing countries: review of hurdles 发展中国家清醒开颅术:障碍回顾
Pub Date : 1900-01-01 DOI: 10.4103/2468-7332.200557
S. Khan, K. Nathani, S. Enam, F. Shafiq
Awake craniotomy is a neurosurgical approach, in which patient is operated under local anesthesia to assess his neurological function intraoperatively. It has multiple advantages over craniotomy under general anesthesia, mainly including improved postoperative neurological status, lower length of hospital, and lower overall cost of hospital stay. Awake craniotomy is commonly practiced in the developed world; however, its role in developing country is limited. Considering the benefits that awake craniotomy offers, it can contribute significant socioeconomic benefits to a developing country, especially with reduce expenditure on health care as well as maintenance of functional capacity of patients to continue work. Development of awake craniotomy in a developing country is a challenge. Multiple hurdles must be overcome before considering the possibility of the procedure. One of the key hurdles is limitation of resources. Others include neuroanesthesia training, extent of disease, and patient selection. Patient's awareness or literacy rate is also a factor to be considered, especially in developing countries where it can be difficult to explain the procedure to the patient. The authors have successfully implemented awake craniotomy in Pakistan recently and have shared how they managed to overcome the hurdles in their case. The hurdles are considerable, but they can be overcome with efforts. The program will be highly beneficial to a developing country and should be attempted for betterment of health-care facilities available to the population.
清醒开颅术是一种神经外科方法,患者在局部麻醉下进行手术,术中评估患者的神经功能。与全麻开颅手术相比,它具有多种优势,主要包括术后神经系统状况改善、住院时间缩短、总住院费用降低。清醒开颅术在发达国家很常见;然而,它在发展中国家的作用有限。考虑到清醒开颅术带来的好处,它可以为发展中国家带来重大的社会经济效益,特别是在减少医疗保健支出以及维持患者继续工作的功能能力方面。清醒开颅术在发展中国家的发展是一个挑战。在考虑这一程序的可能性之前,必须克服多重障碍。关键的障碍之一是资源的限制。其他包括神经麻醉训练、疾病程度和患者选择。患者的意识或识字率也是一个需要考虑的因素,特别是在发展中国家,很难向患者解释手术程序。这组作者最近在巴基斯坦成功地实施了清醒开颅手术,并分享了他们是如何克服障碍的。障碍是相当大的,但通过努力是可以克服的。该方案将对发展中国家非常有益,应尝试改善向人民提供的保健设施。
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引用次数: 7
Management of oral complications in irradiated head and neck cancer patients: Literature review 放疗头颈癌患者口腔并发症的处理:文献回顾
Pub Date : 1900-01-01 DOI: 10.4103/ijssr.ijssr_6_18
M. Hameed, K. Zafar, Robia Ghafoor
The incidence of head and neck cancer is increasing and it is regarded as one of the leading causes of morbidity and mortality. The treatment of head and neck carcinoma is very challenging and depends on the stage of the disease. Radiotherapy is largely employed as primary therapy, adjuvant to surgery, or in combination with chemotherapy for the treatment of head and neck carcinomas. Patients undergoing radiotherapy are prone to a range of short- and long-term complications which adversely affects their health and quality of life. Management of these complications is complex and based on early detection, prevention, and oral care before, during, and after the treatment, to establish the best oral care pathway for these patients. Dental management of these patients is especially important to maintain oral hygiene, overall health, and nutrition status. Management involves multidisciplinary team approach which includes dental practitioners and the oncology team not only in the primary treatment but also in the long-term care and maintenance. It is, therefore, essential for clinicians involved in cancer treatment and cancer survivors to be aware of prevention and management these complications. The aim of this review is to highlight importance of postoperative complications associated with radiotherapy and to draw attention of multidisciplinary teams involved in cancer management toward dental needs of patients treated with radiation therapy, to ensure good quality care and better quality of life in irradiated head and neck cancer patients.
头颈癌的发病率正在上升,它被认为是发病率和死亡率的主要原因之一。头颈癌的治疗是非常具有挑战性的,取决于疾病的阶段。放疗主要作为头颈癌的主要治疗方法,辅助手术治疗,或与化疗联合治疗。接受放射治疗的患者容易出现一系列短期和长期并发症,对他们的健康和生活质量产生不利影响。这些并发症的管理是复杂的,基于早期发现、预防和治疗前、治疗中和治疗后的口腔护理,为这些患者建立最佳的口腔护理途径。这些患者的牙科管理对于保持口腔卫生、整体健康和营养状况尤为重要。管理涉及多学科团队方法,包括牙科医生和肿瘤团队,不仅在初级治疗,而且在长期护理和维护。因此,对于参与癌症治疗的临床医生和癌症幸存者来说,了解预防和管理这些并发症是至关重要的。本综述的目的是强调与放疗相关的术后并发症的重要性,并引起参与癌症管理的多学科团队对放射治疗患者牙科需求的关注,以确保高质量的护理和放疗头颈癌患者更好的生活质量。
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引用次数: 1
Use of bacterial cultures in open wound fractures: A prospective cohort study 细菌培养在开放性伤口骨折中的应用:一项前瞻性队列研究
Pub Date : 1900-01-01 DOI: 10.4103/ijssr.ijssr_20_17
O. Hasan, H. A. Rahim Khan, S. Mustafa, Z. A. Muhammad, T. Ahmad
Introduction: Open fractures are a big challenge for surgeons to treat due to wound contamination leading to infection is a well established complication. To overcome this complication, prophylactic antibiotic therapy is routinely recommended for open fractures. Methods: A single center, prospective cohort study was conducted on patients at a tertiary care academic center to assess surgical site infection following fixation of upper and lower limb open fractures. In this study, we aimed to identify the utility of postdebridement cultures for predicting postoperative wound infection with the identification of association between the incidence of infection and factors such as age, gender, fracture site, cause of injury, and the time between injury and presentation at hospital. Results: Postdebridement cultures of 46 patients were collected, of which 28.3% showed microbial growth. During the hospital stay, three patients developed clinically deep wound infection. Postdebridement culture growth was not significantly associated with the development of clinical infection within the hospital stay (P = 0.188). Out of 43 remaining patients, 11 patients develop wound infection on follow up. Four out of 11 had positive growth on initial cultures. Conclusion: In this study, we evaluated that postdebridement wound cultures were not useful in predicting wound infection in the postoperative period.
开放性骨折对外科医生来说是一个很大的挑战,因为伤口污染导致感染是一个公认的并发症。为了克服这种并发症,预防性抗生素治疗通常被推荐用于开放性骨折。方法:对某三级医疗学术中心的患者进行单中心前瞻性队列研究,以评估上肢和下肢开放性骨折固定后手术部位感染。在这项研究中,我们的目的是确定清创后培养在预测术后伤口感染方面的作用,并确定感染发生率与年龄、性别、骨折部位、损伤原因以及受伤至住院时间等因素之间的关系。结果:收集46例患者的清创后培养物,其中28.3%的患者有微生物生长。住院期间,3例患者出现临床深部伤口感染。清创后培养物生长与住院期间临床感染的发生无显著相关(P = 0.188)。其余43例患者中,11例患者在随访中出现伤口感染。11个中有4个在初始培养中呈阳性生长。结论:在本研究中,我们评估了清创后伤口培养在预测术后伤口感染方面的作用。
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引用次数: 1
Career building starts in the mind 事业的建立始于思想
Pub Date : 1900-01-01 DOI: 10.4103/ijssr.ijssr_13_17
M. Borrelli, R. Farwana, R. Agha
There is enormous flexibility in the careers of medical professionals. Careers can be defining, motivating, and inspiring. Careers require continual and active engagement in their construction, and constantly evolve as new experiences and knowledge is gained. Career building starts with the development and identification of ideas, aims, and values, which alter attitudes, habits, and ultimately shape behaviors to achieve aspirations. This article discusses the ideas and strategic approaches to optimizing experiences and building a career within medicine.
医疗专业人员的职业有很大的灵活性。职业可以定义、激励和鼓舞人。职业需要持续和积极地参与其建设,并随着获得新的经验和知识而不断发展。职业生涯的建立始于想法、目标和价值观的发展和认同,这些想法、目标和价值观会改变态度、习惯,并最终塑造行为,以实现抱负。本文讨论了优化经验和在医学领域建立职业生涯的想法和战略方法。
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引用次数: 2
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