Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.6413
J. L. Longa López, J. L. Dinamarca-Montecinos, Koni Mejía-Rojas, Astrid C. Bernaola Cuadro, Jessica B. Ampuero Bárcena, Leonardo Palacios-Sánchez, Mariano Fernandez-Fairen
Based on a bibliographic review of the literature, a consensus of international experts has been carried out on the use of vitamins B1, B6, B12, in their deficiencies, and in the peripheral neuropathy that may be associated with them, to optimize the management of these conditions. Several questions considered important and worthy of being addressed and clarified were raised, retaining nine of them for further discussion to achieve consensus. Forty one recommendations on the management of these conditions have been proposed, with unanimity of the participants in the consensus. This has been an attempt to clarify controversial points, assisting the clinician's attitude in current medical practice.
{"title":"Vitamins B1, B6, and B12 and Peripheral Neuropathies: International expert consensus","authors":"J. L. Longa López, J. L. Dinamarca-Montecinos, Koni Mejía-Rojas, Astrid C. Bernaola Cuadro, Jessica B. Ampuero Bárcena, Leonardo Palacios-Sánchez, Mariano Fernandez-Fairen","doi":"10.25176/rfmh.v24i1.6413","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.6413","url":null,"abstract":"Based on a bibliographic review of the literature, a consensus of international experts has been carried out on the use of vitamins B1, B6, B12, in their deficiencies, and in the peripheral neuropathy that may be associated with them, to optimize the management of these conditions. Several questions considered important and worthy of being addressed and clarified were raised, retaining nine of them for further discussion to achieve consensus. Forty one recommendations on the management of these conditions have been proposed, with unanimity of the participants in the consensus. This has been an attempt to clarify controversial points, assisting the clinician's attitude in current medical practice.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.5973
Renzo S. Valle Farfan, Alejandro M. Peña Villalobos, Walter J. Espinoza Hernandez, Steffano A. Valle Farfan
Milar Tuberculosis (TB) is a presentation with a fatal outcome if it is not diagnosed or treated on time; although certain conditions are required to develop this presentation. In this In this article, the case of a 48-year-old man with no pathological history is studied, who started the disease with a time of six months with an initial diffuse gastrointestinal pain and later one month before admission presented progressive respiratory symptoms; he was admitted for emergencies where bilateral diffuse miliary compromise was evident in the chest computed tomography; upon admission, he was administered oxygen and support measures, an HIV test was obtained which was negative, and positive results were obtained in the sputum smear microscopy. His clinical evolution was stationary until the administration of antituberculosis therapy, observing slight clinical improvement, likewise, low doses of corticosteroids were administered after which a favorable evolution was demonstrated and he was discharged.
{"title":"Miliary tuberculosis in an immunocompetent patient: Case report","authors":"Renzo S. Valle Farfan, Alejandro M. Peña Villalobos, Walter J. Espinoza Hernandez, Steffano A. Valle Farfan","doi":"10.25176/rfmh.v24i1.5973","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.5973","url":null,"abstract":"Milar Tuberculosis (TB) is a presentation with a fatal outcome if it is not diagnosed or treated on time; although certain conditions are required to develop this presentation. In this In this article, the case of a 48-year-old man with no pathological history is studied, who started the disease with a time of six months with an initial diffuse gastrointestinal pain and later one month before admission presented progressive respiratory symptoms; he was admitted for emergencies where bilateral diffuse miliary compromise was evident in the chest computed tomography; upon admission, he was administered oxygen and support measures, an HIV test was obtained which was negative, and positive results were obtained in the sputum smear microscopy. His clinical evolution was stationary until the administration of antituberculosis therapy, observing slight clinical improvement, likewise, low doses of corticosteroids were administered after which a favorable evolution was demonstrated and he was discharged.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.6340
María C. Huambo Panduro, Andrea P. Ramirez-Ortega, Luis Roldán-Arbieto, José M. Vela-Ruiz
Objective: To determine the factors associated with jaundice requiring phototherapy. Material and Methods: An observational, analytical, and retrospective case-control study was conducted. Medical records of 212 patients aged 0 to 7 days from the neonatology service at Hospital Carlos Lanfranco La Hoz were reviewed, divided into 106 cases (with phototherapy) and 106 controls (without phototherapy). Results: Preterm neonates showed a significant association with an OR: 5.526; 95% CI (2.038-14.981), P= 0.001; and ABO incompatibility had an OR: 4.373, 95% CI (1.934-9.889), P= 0.001. However, birth weight, Rh incompatibility, neonatal sepsis, maternal urinary tract infection, and maternal anemia were not associated with the need for phototherapy. Conclusions: There is an association between preterm neonates and ABO incompatibility with the requirement for phototherapy.
目的确定需要光疗的黄疸的相关因素。材料与方法：进行了一项观察、分析和回顾性病例对照研究。研究人员查阅了卡洛斯-兰弗兰科-拉霍兹医院新生儿科 212 名 0 至 7 天大患者的病历，将其分为 106 例（接受光疗）和 106 例对照（未接受光疗）。结果显示早产儿与光疗有显著关联，OR：5.526；95% CI (2.038-14.981)，P= 0.001；ABO血型不合的OR：4.373，95% CI (2.038-14.981)，P= 0.001：4.373，95% CI (1.934-9.889)，P= 0.001。然而，出生体重、Rh 不相容、新生儿败血症、产妇尿路感染和产妇贫血与光疗需求无关。结论早产新生儿和 ABO 不相容与光疗需求之间存在关联。
{"title":"Associated factors with jaundice requiring phototherapy: a case-control study in a hospital in Peru","authors":"María C. Huambo Panduro, Andrea P. Ramirez-Ortega, Luis Roldán-Arbieto, José M. Vela-Ruiz","doi":"10.25176/rfmh.v24i1.6340","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.6340","url":null,"abstract":"Objective: To determine the factors associated with jaundice requiring phototherapy. Material and Methods: An observational, analytical, and retrospective case-control study was conducted. Medical records of 212 patients aged 0 to 7 days from the neonatology service at Hospital Carlos Lanfranco La Hoz were reviewed, divided into 106 cases (with phototherapy) and 106 controls (without phototherapy). Results: Preterm neonates showed a significant association with an OR: 5.526; 95% CI (2.038-14.981), P= 0.001; and ABO incompatibility had an OR: 4.373, 95% CI (1.934-9.889), P= 0.001. However, birth weight, Rh incompatibility, neonatal sepsis, maternal urinary tract infection, and maternal anemia were not associated with the need for phototherapy. Conclusions: There is an association between preterm neonates and ABO incompatibility with the requirement for phototherapy.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.5900
C. J. Tinoco Plasencia
Objective: Develop an articles review to evaluate the existing evidence on blockchain technology applied in medicine. Methods: The study was of a documentary type, bibliographic design, framed in a systematic review. The harvest of articles was carried out in the Scopus, Web of Sciences, Pro Quest and ScienceDirect databases from January 1, 2018 to July 31, 2023. The descriptors were blockchain, technology and medicine. The PRISMA diagram was prepared considering the inclusion criteria: original articles, with open access; that address the subject and in any language. The search yielded 70 articles, of which 11 formed the sample. Results: The various applications of blockchain technology in medicine were discussed, including its integration with artificial intelligence (AI) for data-centric analysis; regarding the development of traceability systems, however, its greatest applicability is in the registration of medical records of patients, whose application was successful. Despite this, its incipient use in medicine was verified due to the lack of studies in this regard. Conclusions: The application of blockchain technology in medicine is very scarce, despite the potential it has for the registration and safeguarding of medical data, therefore, its study should be deepened.
目标：撰写一篇文章综述，评估区块链技术应用于医学领域的现有证据。研究方法本研究采用文献式、书目式设计，以系统综述为框架。从2018年1月1日至2023年7月31日，在Scopus、Web of Sciences、Pro Quest和ScienceDirect数据库中进行了文章收录。描述符为区块链、技术和医学。考虑到纳入标准，编制了 PRISMA 图表：开放存取的原创文章；涉及主题且使用任何语言。搜索结果为 70 篇文章，其中 11 篇构成样本。研究结果讨论了区块链技术在医学中的各种应用，包括其与人工智能（AI）的整合，用于以数据为中心的分析；关于可追溯性系统的开发，其最大的适用性在于患者医疗记录的登记，其应用是成功的。尽管如此，由于缺乏这方面的研究，其在医学中的应用仍处于起步阶段。结论：尽管区块链技术在登记和保护医疗数据方面具有潜力，但其在医学中的应用却非常少，因此，应深化对区块链技术的研究。
{"title":"Blockchain technology applied in medicine: a systematic review","authors":"C. J. Tinoco Plasencia","doi":"10.25176/rfmh.v24i1.5900","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.5900","url":null,"abstract":"Objective: Develop an articles review to evaluate the existing evidence on blockchain technology applied in medicine. Methods: The study was of a documentary type, bibliographic design, framed in a systematic review. The harvest of articles was carried out in the Scopus, Web of Sciences, Pro Quest and ScienceDirect databases from January 1, 2018 to July 31, 2023. The descriptors were blockchain, technology and medicine. The PRISMA diagram was prepared considering the inclusion criteria: original articles, with open access; that address the subject and in any language. The search yielded 70 articles, of which 11 formed the sample. Results: The various applications of blockchain technology in medicine were discussed, including its integration with artificial intelligence (AI) for data-centric analysis; regarding the development of traceability systems, however, its greatest applicability is in the registration of medical records of patients, whose application was successful. Despite this, its incipient use in medicine was verified due to the lack of studies in this regard. Conclusions: The application of blockchain technology in medicine is very scarce, despite the potential it has for the registration and safeguarding of medical data, therefore, its study should be deepened.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.6427
Oswaldo Salaverry García
Laura Gutiérrez Dulanto has been highlighted for her status as the first woman to graduate in Medicine in Peru. Her high intellectual qualities have been noted from various perspectives, as well as her effort and tenacity to overcome the difficulties of pursuing university studies, particularly in scientific disciplines, then reserved exclusively for men. It has been pointed out, however, that due to the limitations imposed on women at the time, she had a diminished professional activity and little scientific production, which has not been reviewed by existing historiography. This article analyzes his scientific production, especially a clinical study developed in a women's hospital in Lima, Peru, showing his ideas about science and medicine and identifying a clear, modern and innovative thought, not exempt from social sensitivity, in addition. to show herself as a keen and thorough observer of clinical-surgical problems.
Laura Gutiérrez Dulanto 作为秘鲁第一位医学专业毕业的女性而备受瞩目。她的高智商素质以及她为克服大学学习中的困难所付出的努力和坚韧不拔的精神受到了多方面的关注，尤其是在当时只有男性才能学习的科学学科方面。然而，有人指出，由于当时对女性的限制，她的专业活动较少，科研成果也不多，而现有的史学界并未对此进行评述。本文分析了她的科研成果，特别是在秘鲁利马一家女子医院开展的临床研究，展示了她对科学和医学的看法，并确定了她清晰、现代和创新的思想，同时也不乏社会敏感性。
{"title":"The first clinical trial by a woman in Peru. Laura E. Rodríguez Dulanto, the first female physician graduated in Peru","authors":"Oswaldo Salaverry García","doi":"10.25176/rfmh.v24i1.6427","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.6427","url":null,"abstract":"Laura Gutiérrez Dulanto has been highlighted for her status as the first woman to graduate in Medicine in Peru. Her high intellectual qualities have been noted from various perspectives, as well as her effort and tenacity to overcome the difficulties of pursuing university studies, particularly in scientific disciplines, then reserved exclusively for men. It has been pointed out, however, that due to the limitations imposed on women at the time, she had a diminished professional activity and little scientific production, which has not been reviewed by existing historiography. This article analyzes his scientific production, especially a clinical study developed in a women's hospital in Lima, Peru, showing his ideas about science and medicine and identifying a clear, modern and innovative thought, not exempt from social sensitivity, in addition. to show herself as a keen and thorough observer of clinical-surgical problems.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.5950
Fernando Ramos Zaga
Introduction: With the changing landscape of medical education, it is crucial to critically examine existing approaches and frameworks. competency-based medical education (CBME) emerges as a promising paradigm shift, which prioritizes learner-centered, outcome-oriented development of skills, knowledge, and attitudes. Objective: To identify the essential structural and procedural adjustments needed for effective implementation of CBME. It underscores the importance of reorganizing educational institutions, adapting instructional and assessment techniques, and fostering acceptance of CBME in the classroom. Results: To effectively deliver CBME, it is imperative to restructure educational institutions to focus on competency-based curricula and personalized instruction. Also, there is a need to modify teaching and assessment strategies to facilitate continuous assessment and active learning. Conclusions: Adopting CBME principles can enable medical education to produce professionals equipped with the skills necessary to meet the dynamic demands of modern medicine.
{"title":"Transforming medical education in the 21st century: the role of competency-based medical education","authors":"Fernando Ramos Zaga","doi":"10.25176/rfmh.v24i1.5950","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.5950","url":null,"abstract":"Introduction: With the changing landscape of medical education, it is crucial to critically examine existing approaches and frameworks. competency-based medical education (CBME) emerges as a promising paradigm shift, which prioritizes learner-centered, outcome-oriented development of skills, knowledge, and attitudes. Objective: To identify the essential structural and procedural adjustments needed for effective implementation of CBME. It underscores the importance of reorganizing educational institutions, adapting instructional and assessment techniques, and fostering acceptance of CBME in the classroom. Results: To effectively deliver CBME, it is imperative to restructure educational institutions to focus on competency-based curricula and personalized instruction. Also, there is a need to modify teaching and assessment strategies to facilitate continuous assessment and active learning. Conclusions: Adopting CBME principles can enable medical education to produce professionals equipped with the skills necessary to meet the dynamic demands of modern medicine.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.5764
Paula Taboada, Marcela Manuzza, Silvina Mastaglia
Objective: To analyze the sociodemographic characteristics and bone health among adult consumers of plant-based diets (PBD). Methods: Individuals aged 18 to 75 were invited to complete a self-administered survey via a digital platform. Results: A total of 1151 participants completed the survey; the majority were women [n=958 (83.2%)], young [age (years): 18-25: 35.8%; 26-35: 39.8%, and 36-45: 17.4%] and single (67.1%). The pattern of PBD consumption was mainly represented by veganism (54.0%), followed by lacto-ovo-vegetarianism (27.7%). The primary reason for their dietary choice was animal welfare (83.5%). Adherence to PBD, based on duration (years), was <1: 12.3%; 1-5: 67.4%; 10-15: 14.8%, and >15: 5.5%. 16% of vegans reported having experienced fractures, and 5.1% reported undergoing bone densitometry. Of these, 88.1% reported normal results, and 11.8% presented osteopenia. No cases of osteoporosis were recorded in the survey. Vitamin B12 was the predominant supplement among PBD consumers (61.4%). Conclusions: PBD consumers constitute a significant minority in our country, predominantly composed of women under 35 years old, with a projected increase in the coming years.
{"title":"Sociodemographic characteristics and bone health in Argentine adults with a plant-based diet","authors":"Paula Taboada, Marcela Manuzza, Silvina Mastaglia","doi":"10.25176/rfmh.v24i1.5764","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.5764","url":null,"abstract":"Objective: To analyze the sociodemographic characteristics and bone health among adult consumers of plant-based diets (PBD). Methods: Individuals aged 18 to 75 were invited to complete a self-administered survey via a digital platform. Results: A total of 1151 participants completed the survey; the majority were women [n=958 (83.2%)], young [age (years): 18-25: 35.8%; 26-35: 39.8%, and 36-45: 17.4%] and single (67.1%). The pattern of PBD consumption was mainly represented by veganism (54.0%), followed by lacto-ovo-vegetarianism (27.7%). The primary reason for their dietary choice was animal welfare (83.5%). Adherence to PBD, based on duration (years), was <1: 12.3%; 1-5: 67.4%; 10-15: 14.8%, and >15: 5.5%. 16% of vegans reported having experienced fractures, and 5.1% reported undergoing bone densitometry. Of these, 88.1% reported normal results, and 11.8% presented osteopenia. No cases of osteoporosis were recorded in the survey. Vitamin B12 was the predominant supplement among PBD consumers (61.4%). Conclusions: PBD consumers constitute a significant minority in our country, predominantly composed of women under 35 years old, with a projected increase in the coming years.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140742139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.6060
Erick Rojas-Valladares, Ismael Aguilar-Salas, Karina Sánchez-Herrera, Ivo Heyerdahl-Viau, Jonatan Benitez-Morales, J. Martínez-Núñez
Introduction: Adverse Drug Reactions (ADR) are unwanted clinical or laboratory manifestations that are related to drug use. ADR are common and are associated with significant risk of morbidity, mortality and hospital admissions. Antipsychotics have a reduced therapeutic window, and have been related to the manifestation of a variety of ADR. Objective: To evaluate the pattern of ADRs due to antipsychotic drugs detected in patients treated at the Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz between December 2021 and May 2022. Methods: Observational, descriptive, prospective and cross-sectional study of a series of cases. The seriousness, severity, and quality of the information in the notification of the ADR were defined in accordance with NOM-220-SSA1-2016, Installation and Operation of Pharmacovigilance, while causality was determined using the Naranjo algorithm. Results: The incidence of ADRs was 59%, with one or more ADR detected in 52 of the 88 patients who were receiving antipsychotic treatment during the study period. Forty-five percent of the ADR had probable causality and 55% possible; only three ADR were classified as serious as they prolonged the hospital stay and endangered the patient's life. Conclusions: The ADR of the gastrointestinal and endocrine systems were the most incidental, with hyperprolactinemia being the most frequent. Olanzapine and clozapine were the medications that caused the most ADR. It is recommended to promote the culture of notification and follow-up of ADR caused by antipsychotic drugs.
{"title":"Analysis of Adverse Drug Reactions caused by antipsychotic drugs in a Mexican health institute","authors":"Erick Rojas-Valladares, Ismael Aguilar-Salas, Karina Sánchez-Herrera, Ivo Heyerdahl-Viau, Jonatan Benitez-Morales, J. Martínez-Núñez","doi":"10.25176/rfmh.v24i1.6060","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.6060","url":null,"abstract":"Introduction: Adverse Drug Reactions (ADR) are unwanted clinical or laboratory manifestations that are related to drug use. ADR are common and are associated with significant risk of morbidity, mortality and hospital admissions. Antipsychotics have a reduced therapeutic window, and have been related to the manifestation of a variety of ADR. Objective: To evaluate the pattern of ADRs due to antipsychotic drugs detected in patients treated at the Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz between December 2021 and May 2022. Methods: Observational, descriptive, prospective and cross-sectional study of a series of cases. The seriousness, severity, and quality of the information in the notification of the ADR were defined in accordance with NOM-220-SSA1-2016, Installation and Operation of Pharmacovigilance, while causality was determined using the Naranjo algorithm. Results: The incidence of ADRs was 59%, with one or more ADR detected in 52 of the 88 patients who were receiving antipsychotic treatment during the study period. Forty-five percent of the ADR had probable causality and 55% possible; only three ADR were classified as serious as they prolonged the hospital stay and endangered the patient's life. Conclusions: The ADR of the gastrointestinal and endocrine systems were the most incidental, with hyperprolactinemia being the most frequent. Olanzapine and clozapine were the medications that caused the most ADR. It is recommended to promote the culture of notification and follow-up of ADR caused by antipsychotic drugs.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.25176/rfmh.v24i1.6468
Roger A. Sernaque Mechato, Stephanie T. Castillo Arias, Silvana RS. Ñaupari Jara, Flor M. Mendoza Barreto
Toxic megacolon is a fatal disease, most commonly occurring as a complication of inflammatory bowel disease, infections, and intestinal ischemia. It is characterized by the presence of bloody diarrhea, abdominal distension, signs of systemic toxicity, and segmental colonic dilation is observed in imaging studies. The diagnosis according to Jalan's criteria are: colonic dilation more than 6cm, three of the following: fever, tachycardia, leukocytosis or anemia, and any of the following criteria: hypotension, hypovolemia, electrolyte disorder and altered mental status. This article presents the case of a female patient who was admitted with abdominal pain and chronic diarrhea with an imaging study showing dilation of the entire colonic framework. The corresponding studies were carried out which indicated that she had a toxic megacolon due to colitis. ulcerative, receives medical treatment with favorable evolution, is discharged and readmitted for septic shock, studies are performed and Clostridium difficile infection is identified, antibiotic treatment is started but the evolution is unfavorable, which caused the death of the patient. The present case represents the high mortality of this disease.
中毒性巨结肠是一种致命疾病，最常见于炎症性肠病、感染和肠缺血的并发症。其特征是出现血性腹泻、腹胀、全身中毒症状，并且在影像学检查中可观察到结肠节段性扩张。根据 Jalan 的诊断标准：结肠扩张超过 6 厘米，具备以下三项：发热、心动过速、白细胞增多或贫血，以及以下任何一项：低血压、低血容量、电解质紊乱和精神状态改变。本文介绍了一名女性患者的病例，她因腹痛和慢性腹泻入院，影像学检查显示整个结肠框架扩张。溃疡性结肠炎引起的中毒性巨结肠，接受药物治疗后病情好转，出院后因脓毒性休克再次入院，进行检查后确定为艰难梭菌感染，开始使用抗生素治疗，但病情发展不利，导致患者死亡。本病例表明这种疾病的死亡率很高。
{"title":"Toxic megacolon. Case report","authors":"Roger A. Sernaque Mechato, Stephanie T. Castillo Arias, Silvana RS. Ñaupari Jara, Flor M. Mendoza Barreto","doi":"10.25176/rfmh.v24i1.6468","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.6468","url":null,"abstract":"Toxic megacolon is a fatal disease, most commonly occurring as a complication of inflammatory bowel disease, infections, and intestinal ischemia. It is characterized by the presence of bloody diarrhea, abdominal distension, signs of systemic toxicity, and segmental colonic dilation is observed in imaging studies. The diagnosis according to Jalan's criteria are: colonic dilation more than 6cm, three of the following: fever, tachycardia, leukocytosis or anemia, and any of the following criteria: hypotension, hypovolemia, electrolyte disorder and altered mental status. This article presents the case of a female patient who was admitted with abdominal pain and chronic diarrhea with an imaging study showing dilation of the entire colonic framework. The corresponding studies were carried out which indicated that she had a toxic megacolon due to colitis. ulcerative, receives medical treatment with favorable evolution, is discharged and readmitted for septic shock, studies are performed and Clostridium difficile infection is identified, antibiotic treatment is started but the evolution is unfavorable, which caused the death of the patient. The present case represents the high mortality of this disease.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Myocardial infarction continues with high mortality rates, from 4.6% to 13.1%. There are predictive risk stratification models, such as the Grace Score, which does not include glycemia as a variable. Patients hospitalized for myocardial infarction with hyperglycemia on admission may have higher mortality, in ST elevated and non-elevated infarcts. Objectives: The objective of this review is to identify and systematize the evidence on hyperglycemia on admission as a biomarker of mortality and heart failure in acute myocardial infarction. Materials and Methods: The search was carried out in the MEDLINE database including the MeSH terms hyperglycemia and hospital mortality or heart failure in myocardial infarction, selecting 12 articles. Results: Hospital mortality was calculated in 11 articles, in 9 of them a significant association was found between hyperglycemia and hospital mortality, both in the bivariate and multivariate analysis, and in 2 articles this association was not demonstrated. For in-hospital mortality, the results of 11 articles included in this review were synthesized. The frequency of occurrence of heart failure was determined in 11 articles, finding a higher frequency in 9 of them. For in-hospital mortality, the results of 11 articles included in this review were synthesized and analyzed, in 8 the analysis was performed in non-diabetics, obtaining OR: 4.15, IC 95% (2.853-6.035), in 3 for diabetics obtaining OR 2.365 IC 95% (1.778- 3,146) and in 6 for the total population finding OR 3,314 (2,910-3,774). Conclusions: Hyperglycemia on admission is associated with increased mortality and frequency of occurrence of heart failure during hospitalization for myocardial infarction, with evidence of moderate quality.
{"title":"Hyperglycemia as a risk factor for in-hospital mortality in myocardial infarction","authors":"Ciro Barrantes-Alarcón, Rosalia Fernández-Coronado, Adriel Olortegui-Yzu","doi":"10.25176/rfmh.v24i1.6341","DOIUrl":"https://doi.org/10.25176/rfmh.v24i1.6341","url":null,"abstract":"Introduction: Myocardial infarction continues with high mortality rates, from 4.6% to 13.1%. There are predictive risk stratification models, such as the Grace Score, which does not include glycemia as a variable. Patients hospitalized for myocardial infarction with hyperglycemia on admission may have higher mortality, in ST elevated and non-elevated infarcts. Objectives: The objective of this review is to identify and systematize the evidence on hyperglycemia on admission as a biomarker of mortality and heart failure in acute myocardial infarction. Materials and Methods: The search was carried out in the MEDLINE database including the MeSH terms hyperglycemia and hospital mortality or heart failure in myocardial infarction, selecting 12 articles. Results: Hospital mortality was calculated in 11 articles, in 9 of them a significant association was found between hyperglycemia and hospital mortality, both in the bivariate and multivariate analysis, and in 2 articles this association was not demonstrated. For in-hospital mortality, the results of 11 articles included in this review were synthesized. The frequency of occurrence of heart failure was determined in 11 articles, finding a higher frequency in 9 of them. For in-hospital mortality, the results of 11 articles included in this review were synthesized and analyzed, in 8 the analysis was performed in non-diabetics, obtaining OR: 4.15, IC 95% (2.853-6.035), in 3 for diabetics obtaining OR 2.365 IC 95% (1.778- 3,146) and in 6 for the total population finding OR 3,314 (2,910-3,774). Conclusions: Hyperglycemia on admission is associated with increased mortality and frequency of occurrence of heart failure during hospitalization for myocardial infarction, with evidence of moderate quality.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：