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SOLITARY FIBROUS TUMOR OF THE BRAIN: A CASE REPORT 脑单发纤维瘤:病例报告
Pub Date : 2023-11-30 DOI: 10.25176/rfmh.v23i4.6050
Valeria Antuanne Ortiz Ramos, Nora Nicole Itusaca Dueñas, Lucia Victoria Ulloa Ordoñez, Ricardo Romulo Paredes Pacual, Jonathan Joel Torres Canqui, Leslie Estefany Yovera Orellana, J. V. Vela Ruiz
Introduction: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that, although typically develop in the visceral pleura, occasionally occur in the intracranial cavity. Furthermore, they are characterized by high rates of metastasis and recurrence. Case Report: We present the case of a 59-year-old male patient with a 3-month history of headache and bradyphrenia. Computed tomography revealed a neoformative tumor infiltrating the nasal cavity, ethmoid sinuses, and anterior cranial fossa, involving the left frontal lobe. The patient underwent two exploratory craniectomies, during which diagnoses suggestive of high-grade glial neoplasia and SFT were made. For precise diagnosis, immunohistochemistry was performed, which was consistent with solitary fibrous tumor. The case is analyzed, focusing particularly on histopathological aspects, the unusual location of this tumor, and its variable clinical manifestations.
导言:孤立性纤维瘤(SFTs)是一种罕见的间叶肿瘤,虽然通常发生在内脏胸膜,但偶尔也会出现在颅腔内。此外,它们还具有高转移率和高复发率的特点。病例报告:本病例为一名 59 岁男性患者,头痛和肾上腺皮质发育迟缓病史长达 3 个月。计算机断层扫描显示,新形成肿瘤浸润鼻腔、乙状窦和前颅窝,累及左额叶。患者接受了两次探查性颅骨切除术,术中诊断为高级别胶质瘤和 SFT。为了精确诊断,对其进行了免疫组化检查,结果与单发纤维瘤一致。本文对该病例进行了分析,尤其侧重于组织病理学方面、该肿瘤的不寻常位置及其多变的临床表现。
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引用次数: 0
RESPUESTA DE LOS AUTORES LA CARTA EL EDITOR “Satisfacción Laboral en Crisis: El Impacto del COVID-19 en el Personal de Salud” 作者回复编辑的信 "危机中的工作满意度:COVID-19 对医护人员的影响"。
Pub Date : 2023-11-30 DOI: 10.25176/rfmh.v23i4.6203
M. L. Chávez Patilongo, M. P. Placencia Medina, María E. Muñoz Zambrano, Margot Quintana Salinas, Amelia Olortegui Moncada
Estimado Editor y autores de la carta. Hemos revisado con gran interés los comentarios de la carta al editor que acompaña al artículo original titulado "Clima y Satisfacción Laboral Prepandemia del Personal de Enfermería en un Servicio de Emergencia," publicado en el Volumen 23, número 02 de 2023 por Chávez M et al., donde se destaca una correlación significativa entre el clima laboral y la satisfacción laboral del equipo de enfermería en el Hospital de Vitarte.
亲爱的编辑和信件作者我们饶有兴趣地阅读了 Chávez M 等人发表在 2023 年第 23 卷第 02 期上的题为 "Climate and Pre-Pandemic Job Satisfaction of Nursing Staff in an Emergency Department"(急诊科护理人员的工作氛围和大流行前的工作满意度)的原文所附的致编辑信中的评论,其中强调了工作氛围与 Vitarte 医院护理团队工作满意度之间的显著相关性。
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引用次数: 0
Mortality of patients hospitalized by COVID 19 in México, systematic review 墨西哥 COVID 19 住院患者的死亡率,系统回顾
Pub Date : 2023-11-30 DOI: 10.25176/rfmh.v23i4.5877
Ana Portocarrerero Granados, Lya A. Castro Rodríguez, Antonio Sandoval Cabrera, M. D. S. Romero Figueroa
Introduction Since the start of the pandemic, Mexico was one of the countries with the highest mortality rates from COVID 19. Objective To determine if type 2 diabetes mellitus, arterial hypertension, and obesity increase mortality in patients diagnosed with COVID-19 who required hospitalization in Mexico. Method Systematic review in Pubmed MeSH, Web of Science, Lilas, Scielo, and Google Scholar with the terms MeSH COVID-19, SARS-COV2, Coronavirus, and Mexico for the years 2020 and 2021, in English or Spanish. Two reviewers selected the studies, two additional reviewers participated in the analysis of the studies. Results Seventy three studies carried out in Mexico from 2020 to 2021 were included with information obtained from the databases of the National Epidemiological Surveillance System of Mexico. With an average age of 52.9 ± 13.27 years, 64% of the included patients were women, in general, a mortality rate of 16.76% (Min-Max 0.77-73.73%) was reported. 71% of the studies (52) did not report specific mortality related to comorbidities the most prevalent pathology was obesity with 24.23% (Min-Max 11.50-71.00%), followed by arterial hypertension 22.23% (Min-Max 2.0-53.96%) and finally Diabetes mellitus with 18.10% (Min-Max 1.83-40.00%). Conclusions The most common comorbidity among patients hospitalized for COVID in Mexico was obesity, followed by type 2 diabetes mellitus and hypertension.
引言 自 COVID-19 大流行开始以来,墨西哥一直是 COVID-19 死亡率最高的国家之一。目的 确定在墨西哥确诊为 COVID-19 并需要住院治疗的患者中,2 型糖尿病、动脉高血压和肥胖是否会增加死亡率。方法 在 Pubmed MeSH、Web of Science、Lilas、Scielo 和 Google Scholar 中以 MeSH COVID-19、SARS-COV2、冠状病毒和墨西哥为关键词,用英语或西班牙语对 2020 年和 2021 年的研究进行系统综述。两名审稿人对研究进行了筛选,另有两名审稿人参与了研究分析。结果 从墨西哥国家流行病监测系统的数据库中获取信息,纳入了 2020 年至 2021 年在墨西哥进行的 73 项研究。平均年龄为(52.9 ± 13.27)岁,64%的研究对象为女性,死亡率为 16.76%(最小值-最大值为 0.77-73.73%)。71%的研究(52 项)未报告与合并症相关的具体死亡率,最常见的病症是肥胖,占 24.23%(最小值为 11.50-71.00%),其次是动脉高血压,占 22.23%(最小值为 2.0-53.96%),最后是糖尿病,占 18.10%(最小值为 1.83-40.00%)。结论 在墨西哥因 COVID 住院的患者中,最常见的合并症是肥胖,其次是 2 型糖尿病和高血压。
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引用次数: 0
Evaluation of clinical aspects related to lower limb amputation among individuals living with type 2 diabetes mellitus in Mexico 对墨西哥 2 型糖尿病患者下肢截肢相关临床问题的评估
Pub Date : 2023-11-30 DOI: 10.25176/rfmh.v23i4.5980
Julio C. Parra Acosta, Laura Ávila Jiménez, Antonio Monroy Noyola, Diana Lizbeth Gómez Galicia, Daniel Álvarez Escobedo, Cairo Toledano Jaimes
Introduction: Diabetes continues to be a leading cause of disability and death in the world's population. About 25% of people with diabetes will develop an ulcer in one of their lower pelvic limbs. Objective: The present study evaluates the clinical aspects related to lower pelvic limb amputation in a cohort of patients with diabetes mellitus. Methods: Retrospective, cross-sectional study, conducted in collaboration between the Mexican Institute of Social Security and the School of Pharmacy of the Autonomous University of Morelos State, involved a review of records of patients with type 2 diabetes mellitus at the Regional General Hospital "Ignacio García Téllez". One hundred clinical and electronic records were selected based on inclusion criteria, which included age over 18 years, affiliation at the study site, diabetes evolution of at least 10 years, pharmacological treatment for diabetes and diagnosis of diabetic foot with complete healing or amputation as an outcome. Statistical analyses were performed using STATA and ethical approval was obtained. Results: Patients with optimal glycemic control by quantifying their fasting glucose levels (<130 mg/dl) as well as their glycated hemoglobin values (< 7%) had a lower frequency of amputations (p˂0.001; Chi2) compared to those patients without adequate glycemic control. Conclusions: Being male, glycosylated hemoglobin values greater than 7% and mean fasting glucose values greater than 130 mg/L were found to increase the likelihood of having a lower extremity amputation.
导言:糖尿病仍然是导致世界人口残疾和死亡的主要原因。约有 25% 的糖尿病患者会在其中一个骨盆下肢发生溃疡。研究目的本研究评估了一组糖尿病患者骨盆下肢截肢的相关临床问题。方法:回顾性横断面研究:墨西哥社会保障研究所和莫雷洛斯州自治大学药学院合作开展了一项回顾性横断面研究,审查了 "伊格纳西奥-加西亚-特莱斯 "地区综合医院 2 型糖尿病患者的病历。根据纳入标准,包括年龄超过 18 岁、隶属于研究地点、糖尿病病程至少 10 年、接受过糖尿病药物治疗以及诊断出糖尿病足并导致完全愈合或截肢,共筛选出 100 份临床和电子病历。使用 STATA 进行统计分析,并获得伦理批准。结果通过量化空腹血糖水平(<130 mg/dl)和糖化血红蛋白值(<7%),血糖控制达标的患者截肢频率低于血糖控制不达标的患者(p˂0.001;Chi2)。结论男性、糖化血红蛋白值大于 7% 和平均空腹血糖值大于 130 mg/L 会增加下肢截肢的可能性。
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引用次数: 0
Effect of oral vitamin D supplementation on psoriasis severity: does it generate significant benefits? 口服维生素 D 补充剂对银屑病严重程度的影响:它能带来显著益处吗?
Pub Date : 2023-11-30 DOI: 10.25176/rfmh.v23i4.5968
Manuel Enrique Duarte Arias, Juan Esteban Ospina Gómez, María Camila Forero Buelvas
Psoriasis is a chronic immune-mediated skin disease with a complex genetic and pathogenic basis, often leading to significant comorbidities and a reduced quality of life. Its prevalence varies globally and exhibits an increasing trend over time. Comorbidities such as psoriatic arthritis, cardiovascular diseases, and mental health issues further compound the burden of psoriasis. Treatment options range from topical therapies to systemic agents, with biologics playing a prominent role in recent years. However, the safety and efficacy of these treatments are continuously assessed through real-world data. Vitamin D has gained attention as a potential therapeutic target due to its role in immune regulation and skin barrier function. This review aims to evaluate the efficacy of oral vitamin D supplementation in ameliorating the severity of psoriasis. After bibliographic search, it was found that psoriasis is a multifaceted condition with significant global implications. Biologics have transformed its management, and oral vitamin D supplementation is a promising avenue for further exploration. A comprehensive, patient-centered approach that considers comorbidities and long-term outcomes is crucial for optimizing psoriasis care. Further research is needed to fully understand the role of vitamin D in psoriasis and its potential as a therapeutic intervention.
银屑病是一种免疫介导的慢性皮肤病,具有复杂的遗传和致病基础,通常会导致严重的并发症和生活质量下降。银屑病的发病率在全球范围内各不相同,并呈逐年上升趋势。银屑病关节炎、心血管疾病和精神健康问题等并发症进一步加重了银屑病的负担。治疗方法从局部治疗到全身用药不等,近年来生物制剂发挥了突出作用。然而,这些治疗方法的安全性和有效性需要不断通过真实世界的数据进行评估。由于维生素 D 在免疫调节和皮肤屏障功能中的作用,它作为一种潜在的治疗靶点受到了关注。本综述旨在评估口服维生素 D 补充剂对改善银屑病严重程度的疗效。经过文献检索,我们发现银屑病是一种对全球具有重大影响的多发性疾病。生物制剂改变了银屑病的治疗方法,而口服维生素 D 补充剂则是一个值得进一步探索的前景广阔的途径。以患者为中心的综合治疗方法考虑了并发症和长期疗效,对于优化银屑病治疗至关重要。要全面了解维生素 D 在银屑病中的作用及其作为治疗干预措施的潜力,还需要进一步的研究。
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引用次数: 0
The control of growth and development in the reduction of anemia in Peru 秘鲁在减少贫血症方面对生长发育的控制
Pub Date : 2023-11-30 DOI: 10.25176/rfmh.v23i4.5497
Evelyn Gabriela Castro Mayta
Introduction: Anemia is a public health problem that mainly affects children under five years of age. Objective: Determine the impact of growth and development control (CRED) in reducing anemia in children under five years of age in Peru considering the analysis of the Demographic and Family Health Survey (ENDES) 2021. Method: Analytical and cross-sectional study with a secondary analysis of data from the 2021 ENDES survey. Results: 31.4% of children under five years of age had anemia, where 38.3% corresponded to rural areas; 34.0%, male children; 56.9%, under one year old; 38.5% were mothers with primary education and 40.8% belonged to the index of the poorest, showing statistically significant differences. In relation to the CRED, it was evident that 32.4% of children who did undergo a CRED and 30.2% of children who did not had anemia. Regarding the place where it was carried out, it was observed that 32.4% of children who were cared for in a health facility and 32.9% of children who were cared for by the nurse had anemia. Conclusion: Anemia is a public health problem that is present and conditioned by various factors and determinants. During the pandemic, the impact of CRED in reducing anemia was ambiguous, so there are assumptions about whether the interventions are having the desired and expected impact.
导言:贫血是一个主要影响五岁以下儿童的公共卫生问题。目标通过对 2021 年人口与家庭健康调查(ENDES)的分析,确定生长发育控制(CRED)对减少秘鲁五岁以下儿童贫血症的影响。研究方法:分析性横断面研究,对 2021 年ENDES 调查数据进行二次分析。研究结果31.4%的五岁以下儿童患有贫血症,其中 38.3%的儿童居住在农村地区;34.0%的儿童为男性;56.9%的儿童年龄在一岁以下;38.5%的母亲接受过初等教育,40.8%的母亲属于最贫困人口,这些数据在统计学上存在显著差异。在 CRED 方面,32.4%接受过 CRED 的儿童和 30.2%没有接受过 CRED 的儿童明显患有贫血症。关于实施地点,在医疗机构接受护理的儿童中有 32.4%患有贫血,在护士护理的儿童中有 32.9%患有贫血。结论贫血是一个公共卫生问题,它的存在和制约因素多种多样。在大流行期间,CRED 在减少贫血方面的影响并不明确,因此,我们可以假设干预措施是否产生了预期和期望的影响。
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引用次数: 0
IMPACT OF ADDICTION TO SOCIAL NETWORKS ON THE MENTAL HEALTH OF HUMAN MEDICINE STUDENTS, IN TIMES OF COVID-19 在 COVID-19 时代,沉迷于社交网络对人类医学学生心理健康的影响
Pub Date : 2023-11-30 DOI: 10.25176/rfmh.v23i4.5920
Fiorella Otero Carrillo, Pamela Rocio Picoy Romero, Rubén Espinoza Rojas, Jhonny De La Cruz Vargas
Objective. To determine the association of addiction to social networks and the consequences in mental health in human medicine students of the Ricardo Palma University, year 2021. Materials and methods. Cross-sectional observational study, with the participation of 454 human medicine students from first to fifth year, chosen by stratified random sampling proportional to size. The instrument was validated, obtaining a Cronbach's Alpha (α=0.90), the questionnaires used were: Addiction to Social Networks (ARS), Depression, Anxiety, Stress Scale (DASS-21) and Pittsburgh Sleep Quality Index (PSQI). In order to evaluate the association between variables, we used crude and adjusted prevalence ratio (PR), using the Poisson regression model with the logarithmic link and with the 95% confidence interval. Results. 65.4% were women, with an average age of 21.2 years. A significant association was found between high social network addiction and mental health (PRc: 2.59; 95% CI: 1.92-3.50; p: 0.000) and, likewise, between high and medium levels of social network addiction. social and with depression, anxiety, stress (p: 0.000) and sleep quality (p<0.010), respectively. 41%, 49.1% and 9.9% of the students presented low, medium and high addiction to social networks, respectively. 57.5% had depression, 56.4% anxiety, 70.5% stress and 77.3% poor sleep quality. Conclusions. There was a strong association between ARS and mental health. Therefore, it is recommended that university students visit mental health specialists quarterly for proper identification, evaluation, and management of the problems generated by ARS.
目的确定里卡多-帕尔马大学(Ricardo Palma University)2021 届人类医学专业学生沉迷社交网络与心理健康后果之间的关联。材料和方法横断面观察研究,454 名一年级至五年级的人类医学专业学生参与了研究。研究工具经过验证,获得了 Cronbach's Alpha(α=0.90),使用的问卷包括使用的问卷包括:社交网络成瘾(ARS)、抑郁、焦虑、压力量表(DASS-21)和匹兹堡睡眠质量指数(PSQI)。为了评估变量之间的关联,我们使用了粗略和调整后的流行率(PR),使用了对数连接的泊松回归模型,并使用了 95% 的置信区间。结果显示65.4%的患者为女性,平均年龄为 21.2 岁。研究发现,社交网络成瘾程度高与心理健康之间存在明显联系(PRc:2.59;95% CI:1.92-3.50;P:0.000),同样,社交网络成瘾程度高与社交网络成瘾程度中等之间也存在明显联系,社交网络成瘾程度高分别与抑郁、焦虑、压力(P:0.000)和睡眠质量(P<0.010)有关。分别有 41%、49.1% 和 9.9%的学生表现出低、中和高社交网络成瘾水平。57.5%的学生患有抑郁症,56.4%的学生焦虑,70.5%的学生压力大,77.3%的学生睡眠质量差。结论ARS 与心理健康之间存在密切联系。因此,建议大学生每季度到心理健康专科就诊,以正确识别、评估和处理 ARS 带来的问题。
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引用次数: 0
Time to treat the climate and nature crisis as one indivisible global health emergency 是时候将气候和自然危机视为一个不可分割的全球卫生紧急事件
Pub Date : 2023-10-30 DOI: 10.25176/rfmh.v23i3.6045
Kamran Abbasi, Kirsten Bibbins Domingo, Robert Mash, Chris Zielinski, Parveen Ali, Stephen Hancocks, Peush Sahni, Virginia Barbour, Richard Horton, Wadeia Mohammad Sharief, Thomas Benfield, Laurie Laybourn Langton, Paul Yonga
Over 200 health journals call on the United Nations, political leaders, and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency.
200多家卫生期刊呼吁联合国、政治领导人和卫生专业人员认识到,气候变化和生物多样性丧失是一个不可分割的危机,必须共同应对,以保护健康和避免灾难。这一全面的环境危机现在非常严重,已成为全球卫生紧急情况。
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引用次数: 0
Leadership styles and job performance in medical professionals at hospital Vitarte– Lima, 2018 Vitarte - Lima医院医疗专业人员的领导风格和工作绩效,2018
Pub Date : 2023-09-30 DOI: 10.25176/rfmh.v23i3.5631
José L. Bedriñana Sotomayor, Marcos J. Saavedra Muñoz
Objective: To determine the relationship between leadership styles and job performance of the medical staff of Hospital Vitarte Lima, 2018. Methods: Descriptive, correlational and cross-sectional study. A non-probabilistic purposive sampling was done by selecting 64 workers. Also, data collection was done through a previously validated questionnaire and internal consistency analysis by Cronbach's alpha. Results: The descriptive statistics determined a 50 % in the Democratic Leadership Style of the dimensions and a level higher than 60 % for Job Performance, the inferential statistics through the Hypothesis Test by Spearman's correlation coefficient (rho = 0.85) showed a high positive correlation in both variables. Conclusion: There is a positive correlation between the dimensions Democratic Leadership Style and job performance, so the creation of quality improvement projects and training for workers is recommended.
目的:了解利马维塔医院2018年医务人员领导风格与工作绩效的关系。方法:描述性、相关性、横断面研究。通过选择64名工人进行非概率有目的抽样。此外,数据收集是通过先前验证的问卷和内部一致性分析Cronbach's alpha完成的。结果:描述性统计表明,民主领导风格在各维度中占50%以上,工作绩效在各维度中占60%以上,通过Spearman相关系数(rho = 0.85)进行假设检验的推论统计表明,两个变量之间存在高度正相关。结论:民主领导风格维度与工作绩效之间存在正相关关系,建议开展质量改进项目和员工培训。
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引用次数: 0
ASSESSMENT OF MYCOBACTERIUM TUBERCULOSIS DRUG-RESISTANCE PATTERNS IN A PUBLIC HOSPITAL OF LIMA, PERU DURING 2022 2022年秘鲁利马一家公立医院结核分枝杆菌耐药模式评估
Pub Date : 2023-09-30 DOI: 10.25176/rfmh.v23i3.5815
Jorge R. Mosqueira Sánchez, María A. Paredes Moreno, Julio C. Layseca Ortiz, Nancy V. Mogrovejo Olivera, Alvaro Oyarce Calderón
Background. Tuberculosis is a public health problem considered to be the world's leading cause of death from an infectious disease among adults. Diagnosis is often challenging and is based on clinical, epidemiological, radiological, bacteriological, histological and biochemical findings. Timely diagnosis, identification of the susceptibility profile and follow-up compliance is important to enable more effective treatment and avoid severe forms of the disease. Aim. Describe the resistance patterns of Mycobacterium tuberculosis identified in the period of the year 2022 at Hospital María Auxiliadora. Material and Methods. This is an observational, cross-sectional study of patients diagnosed with tuberculosis throughout the year 2022 in the Tuberculosis Center of Excellence (TB COE), division of the respiratory medicine department at the Hospital Maria Auxiliadora, Lima, Peru. Data was collected from the medical records which was then included for the statistical analysis. The clinical and demographic characteristics were described by absolute frequencies and percentages. Chi-square test and Fisher's exact test were used to evaluate the association between the sensitivity profile of tuberculosis and the independent variables. A p-value < 0.05 was considered as statistically significant. Results. A total of 261 medical records were included in the present study. The most frequent age group was 17-59 years old, the majority were male (62.1%) and 15.7% were relapses, as established on national technical standard. Of the total, 89.7% were sensitive to first line drugs; 6.1% of the patients were multidrug-resistant (MDR), and 0.8% presented extensively drug-resistance (XDR); likewise, 0.8% and 2.7% presented resistance for rifampicin only and resistance for isoniazid only respectively. HIV infection was found at 14.2%. The most common form of tuberculosis was pulmonary (49%) followed by pleural tuberculosis (21.8%). Conclusion. Tuberculosis is a worldwide condition whose drug-resistance patterns continue evolving. However, in our hospital, a southern Peru reference Center, most TB patients are still sensitive to first line drugs. Only a small amount of MDR and XDR patients were found. Moreover, the most common clinical presentation was pulmonary followed by pleural tuberculosis.
背景。结核病是一个公共卫生问题,被认为是世界上成年人感染性疾病死亡的主要原因。诊断通常具有挑战性,并基于临床、流行病学、放射学、细菌学、组织学和生化检查结果。及时诊断、确定易感性概况和随访依从性对于实现更有效的治疗和避免疾病的严重形式非常重要。的目标。描述2022年期间在María Auxiliadora医院发现的结核分枝杆菌耐药模式。材料和方法。这是一项观察性横断面研究,研究对象是秘鲁利马Maria Auxiliadora医院呼吸内科结核病卓越中心(TB COE) 2022年全年诊断为结核病的患者。从医疗记录中收集数据,然后纳入统计分析。临床和人口学特征用绝对频率和百分比来描述。采用卡方检验和Fisher精确检验评价结核病的敏感性与自变量之间的关系。p值<0.05认为有统计学意义。结果。本研究共纳入261份医疗记录。以17-59岁年龄组最常见,男性居多(62.1%),复发率15.7%(国家技术标准)。其中对一线药物敏感的占89.7%;6.1%的患者为多药耐药(MDR), 0.8%的患者广泛耐药(XDR);对利福平和异烟肼的耐药率分别为0.8%和2.7%。艾滋病毒感染率为14.2%。最常见的结核形式是肺结核(49%),其次是胸膜结核(21.8%)。结论。结核病是一种世界性疾病,其耐药模式在不断演变。然而,在我们医院,秘鲁南部的参考中心,大多数结核病患者仍然对一线药物敏感。仅发现少量MDR和XDR患者。此外,最常见的临床表现是肺部,其次是胸膜结核。
{"title":"ASSESSMENT OF MYCOBACTERIUM TUBERCULOSIS DRUG-RESISTANCE PATTERNS IN A PUBLIC HOSPITAL OF LIMA, PERU DURING 2022","authors":"Jorge R. Mosqueira Sánchez, María A. Paredes Moreno, Julio C. Layseca Ortiz, Nancy V. Mogrovejo Olivera, Alvaro Oyarce Calderón","doi":"10.25176/rfmh.v23i3.5815","DOIUrl":"https://doi.org/10.25176/rfmh.v23i3.5815","url":null,"abstract":"Background. Tuberculosis is a public health problem considered to be the world's leading cause of death from an infectious disease among adults. Diagnosis is often challenging and is based on clinical, epidemiological, radiological, bacteriological, histological and biochemical findings. Timely diagnosis, identification of the susceptibility profile and follow-up compliance is important to enable more effective treatment and avoid severe forms of the disease. Aim. Describe the resistance patterns of Mycobacterium tuberculosis identified in the period of the year 2022 at Hospital María Auxiliadora. Material and Methods. This is an observational, cross-sectional study of patients diagnosed with tuberculosis throughout the year 2022 in the Tuberculosis Center of Excellence (TB COE), division of the respiratory medicine department at the Hospital Maria Auxiliadora, Lima, Peru. Data was collected from the medical records which was then included for the statistical analysis. The clinical and demographic characteristics were described by absolute frequencies and percentages. Chi-square test and Fisher's exact test were used to evaluate the association between the sensitivity profile of tuberculosis and the independent variables. A p-value < 0.05 was considered as statistically significant. Results. A total of 261 medical records were included in the present study. The most frequent age group was 17-59 years old, the majority were male (62.1%) and 15.7% were relapses, as established on national technical standard. Of the total, 89.7% were sensitive to first line drugs; 6.1% of the patients were multidrug-resistant (MDR), and 0.8% presented extensively drug-resistance (XDR); likewise, 0.8% and 2.7% presented resistance for rifampicin only and resistance for isoniazid only respectively. HIV infection was found at 14.2%. The most common form of tuberculosis was pulmonary (49%) followed by pleural tuberculosis (21.8%). Conclusion. Tuberculosis is a worldwide condition whose drug-resistance patterns continue evolving. However, in our hospital, a southern Peru reference Center, most TB patients are still sensitive to first line drugs. Only a small amount of MDR and XDR patients were found. Moreover, the most common clinical presentation was pulmonary followed by pleural tuberculosis.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Revista de la Facultad de Medicina Humana
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