E. Marian, C. Morgovan, L. Vicaș, T. Jurca, A. Pallag, M. Mureşan, O. Frent
Study objectives: were evaluation of the content in bioactive compounds with antioxidant properties of the species Viola x wittrockiana Gams flowers, cultivated in the Bihor region of Romania. Materials and Methods: Viola x wittrockiana Gams flowers were harvested, dried, then prepared for to evaluate the phenolic and flavonoid contents and for determined antioxidant capacity by the following methods: DPPH and FRAP. Results – after determined the total polyphenolic compounds content the concentration found was contained between 2.5-4.52 mg GAE/100 g dry flowers and flavonoids were contained between 46.75-54.49 mg QE/100 g dry flowers garden pansies. Conclusions: strong correlation between the polyphenols and flavonoids content and antioxidant properties which have been evaluated at the extracts obtained from the pansy flowers have shown that the plant has inhibition capacity on DPPH reagent contained between 62.644 – 92.241% and antioxidant capacity which varies between 494.588-889.882 made by FRAP method.
研究目的：评估罗马尼亚比霍尔地区种植的Viola x wittrockiana Gams花中具有抗氧化特性的生物活性化合物的含量。材料与方法：采用DPPH和FRAP两种方法，分别对紫百合花进行采收、干燥、制备，测定其酚类和类黄酮含量，并测定其抗氧化能力。结果-在测定总多酚化合物含量后，发现浓度在2.5-4.52 mg GAE/100 g干花之间，类黄酮含量在46.75-54.49 mg QE/100 g干花花园三色堇之间。结论：从三色堇花提取物中提取的多酚、黄酮类化合物含量与抗氧化性能之间具有很强的相关性，表明该植物对FRAP法生产的DPPH试剂的抑制能力在62.644～92.241%之间，抗氧化能力在494.588～889.882之间。
{"title":"Determination of the total content of polyphenols, flavonoids and the antioxidant capacity of extracts from viola x wittrockiana flowers","authors":"E. Marian, C. Morgovan, L. Vicaș, T. Jurca, A. Pallag, M. Mureşan, O. Frent","doi":"10.37897/rjphp.2022.1.3","DOIUrl":"https://doi.org/10.37897/rjphp.2022.1.3","url":null,"abstract":"Study objectives: were evaluation of the content in bioactive compounds with antioxidant properties of the species Viola x wittrockiana Gams flowers, cultivated in the Bihor region of Romania. Materials and Methods: Viola x wittrockiana Gams flowers were harvested, dried, then prepared for to evaluate the phenolic and flavonoid contents and for determined antioxidant capacity by the following methods: DPPH and FRAP. Results – after determined the total polyphenolic compounds content the concentration found was contained between 2.5-4.52 mg GAE/100 g dry flowers and flavonoids were contained between 46.75-54.49 mg QE/100 g dry flowers garden pansies. Conclusions: strong correlation between the polyphenols and flavonoids content and antioxidant properties which have been evaluated at the extracts obtained from the pansy flowers have shown that the plant has inhibition capacity on DPPH reagent contained between 62.644 – 92.241% and antioxidant capacity which varies between 494.588-889.882 made by FRAP method.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48325256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Ghiciuc, Ionela-Alina Grosu-Creangă, D. Petrescu, A. Vicovan, Ioana Maria Onofrei, I. Roșca
Antibiotic administration commonly induces allergic reactions, dysmicrobism and microbial resistance, but long-term effects due to changes in gut microbiota composition are difficult to assess. This paper aims to identify in the literature adverse effects induced by changes in gut microbiota composition after perinatal administration of antibiotics. Antibiotic administration during pregnancy is a predisposing factor for the development of bronchial asthma, eczema, or allergic rhinitis in children, but does not support the hypothesis as being a risk factor for childhood obesity/overweight. The effect on the newborn’s microbiota of prophylactic administration of antibiotics during caesarean section is controversial. Postnatal treatments with antibiotics frequently causes intestinal dysmicrobism, the most severe form being necrotizing enterocolitis, especially among premature infants, but effects on the changes in body weight are controversial. Early administration of broad-spectrum antibiotics, particularly macrolides and cephalosporins, is strongly associated with the development of bronchial asthma at age 5 years. Recently, altered auditory processing and changes in recognition memory were described in newborn exposed to antibiotics in the absence of infection. More studies are needed to clarify the association between the type of antibiotic, the frequency, respectively period (both prenatal and intrapartum) of administration and long-term effects.
{"title":"Adverse effects due to changes in the composition of the intestinal microbiota as result of the administration of antibiotics during the perinatal period","authors":"C. Ghiciuc, Ionela-Alina Grosu-Creangă, D. Petrescu, A. Vicovan, Ioana Maria Onofrei, I. Roșca","doi":"10.37897/rjphp.2022.1.1","DOIUrl":"https://doi.org/10.37897/rjphp.2022.1.1","url":null,"abstract":"Antibiotic administration commonly induces allergic reactions, dysmicrobism and microbial resistance, but long-term effects due to changes in gut microbiota composition are difficult to assess. This paper aims to identify in the literature adverse effects induced by changes in gut microbiota composition after perinatal administration of antibiotics. Antibiotic administration during pregnancy is a predisposing factor for the development of bronchial asthma, eczema, or allergic rhinitis in children, but does not support the hypothesis as being a risk factor for childhood obesity/overweight. The effect on the newborn’s microbiota of prophylactic administration of antibiotics during caesarean section is controversial. Postnatal treatments with antibiotics frequently causes intestinal dysmicrobism, the most severe form being necrotizing enterocolitis, especially among premature infants, but effects on the changes in body weight are controversial. Early administration of broad-spectrum antibiotics, particularly macrolides and cephalosporins, is strongly associated with the development of bronchial asthma at age 5 years. Recently, altered auditory processing and changes in recognition memory were described in newborn exposed to antibiotics in the absence of infection. More studies are needed to clarify the association between the type of antibiotic, the frequency, respectively period (both prenatal and intrapartum) of administration and long-term effects.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46707953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Ochiuz, E. G. Popa, C. Ghiciuc, Alexandra Bujor, S. Mousa, C. Gafitanu
Onychosis therapy is an ongoing challenge considering the diversity of nail pathology and the barrier function of the nail plate. Among the nail diseases, we identify the primary onychodystrophies, caused by tics or mental disorders, as well as severe onychoses, caused by bacterial and/or fungal infections, manifested by the degradation of the matrix and the nail bed. Onychosis treatment is complex, lasting 6-8 months, and is often frustrating for both patients and healthcare professionals. In this article we have described a series of common onychoses from the etiopathological point of view, briefly presenting the general therapeutic approach. We also highlighted the classic and modern pharmaceutical formulations used in local nail medication. From the perspective of recent approaches, there is the development of therapeutic systems for transungual administration that ensure the prolonged and controlled drug release to optimize the pharmacotechnical performance of medication used in local therapy of onychosis.
{"title":"Conventional and modern therapeutic approaches in topical medication of onicosis","authors":"L. Ochiuz, E. G. Popa, C. Ghiciuc, Alexandra Bujor, S. Mousa, C. Gafitanu","doi":"10.37897/rjphp.2021.4.2","DOIUrl":"https://doi.org/10.37897/rjphp.2021.4.2","url":null,"abstract":"Onychosis therapy is an ongoing challenge considering the diversity of nail pathology and the barrier function of the nail plate. Among the nail diseases, we identify the primary onychodystrophies, caused by tics or mental disorders, as well as severe onychoses, caused by bacterial and/or fungal infections, manifested by the degradation of the matrix and the nail bed. Onychosis treatment is complex, lasting 6-8 months, and is often frustrating for both patients and healthcare professionals. In this article we have described a series of common onychoses from the etiopathological point of view, briefly presenting the general therapeutic approach. We also highlighted the classic and modern pharmaceutical formulations used in local nail medication. From the perspective of recent approaches, there is the development of therapeutic systems for transungual administration that ensure the prolonged and controlled drug release to optimize the pharmacotechnical performance of medication used in local therapy of onychosis.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49405944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bianca Laura Sugac, T. Pop, Monica Boros, A. Huniadi, L. Vicaș, T. Jurca, E. Marian, A. Pallag, Florina Miere (Groza), Liana Ștefan, M. Mureşan
On 11 March 2020 World Health Organization declared the Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (SARS–CoV–2, 2019 – nCoV) a global pandemic. After a year, there are still many unknowns about peripartum women suffering from COVID – 19. In some pregnant women, respiratory failure can rapidly progress to acute respiratory distress syndrome (ARDS) which is requiring extracorporeal membrane oxygenation (ECMO) as a life – saving therapy. This motivated our team to report the case of a 22-year-old pregnant woman suffering from obesity, gestational hypertension with a severe COVID – 19 forms associated with ARDS. We want to highlight the potential benefits of therapeutic management, after an analysis of clinical and paraclinical parameters, especially because the patient was discharge after 40 days with no major complications. The urgent delivery, early initiation of ECMO and the complex pharmacological therapy (including Remdesivir) resulted in favorable maternal– fetal outcomes.
{"title":"Evaluation of the clinical efficiency of COVID drug treatment of clinical-paraclinical parameters in a critical case of COVID-19 with severe pulmonary dysfunction after cesarean section","authors":"Bianca Laura Sugac, T. Pop, Monica Boros, A. Huniadi, L. Vicaș, T. Jurca, E. Marian, A. Pallag, Florina Miere (Groza), Liana Ștefan, M. Mureşan","doi":"10.37897/rjphp.2021.4.1","DOIUrl":"https://doi.org/10.37897/rjphp.2021.4.1","url":null,"abstract":"On 11 March 2020 World Health Organization declared the Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (SARS–CoV–2, 2019 – nCoV) a global pandemic. After a year, there are still many unknowns about peripartum women suffering from COVID – 19. In some pregnant women, respiratory failure can rapidly progress to acute respiratory distress syndrome (ARDS) which is requiring extracorporeal membrane oxygenation (ECMO) as a life – saving therapy. This motivated our team to report the case of a 22-year-old pregnant woman suffering from obesity, gestational hypertension with a severe COVID – 19 forms associated with ARDS. We want to highlight the potential benefits of therapeutic management, after an analysis of clinical and paraclinical parameters, especially because the patient was discharge after 40 days with no major complications. The urgent delivery, early initiation of ECMO and the complex pharmacological therapy (including Remdesivir) resulted in favorable maternal– fetal outcomes.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47353468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Vari, B. Ösz, George Jîtcă, Alexandra Groșan, M. Stoica
Self-medication can be defined as the use of over-the-counter medications, released at the patient’s request. In order to be effective and to reduce the risk of side effects and iatrogenic accidents, their release should be accompanied by specialist advice, which is the prerogative of the pharmacist. Thus, self-medication requires a drug-patient-pharmacist relationship. This paper highlights some practical aspects of OTC medication. We also present some particular cases of medicines released under the OTC regime, but also of medicines that currently require a prescription, although they were initially released on request.
{"title":"The patient, the OTC drug, and the pharmacist – an (in)separable triad? A critical analysis of self-medication","authors":"C. Vari, B. Ösz, George Jîtcă, Alexandra Groșan, M. Stoica","doi":"10.37897/rjphp.2021.3.2","DOIUrl":"https://doi.org/10.37897/rjphp.2021.3.2","url":null,"abstract":"Self-medication can be defined as the use of over-the-counter medications, released at the patient’s request. In order to be effective and to reduce the risk of side effects and iatrogenic accidents, their release should be accompanied by specialist advice, which is the prerogative of the pharmacist. Thus, self-medication requires a drug-patient-pharmacist relationship. This paper highlights some practical aspects of OTC medication. We also present some particular cases of medicines released under the OTC regime, but also of medicines that currently require a prescription, although they were initially released on request.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48386785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives. To evaluate the in vitro virucidal effect of the combination of cetylpyridinium chloride (CPC) and benzydamine hydrochloride (BH) as a throat lozenge against the novel SARS-CoV-2. Material and methods. The study evaluated the viral presence and titre in cell cultures by using SARS-CoV-2 virus incubated for 1, 5, 15 minutes, with three different concentrations of three different active substances (CPC, free BH/ CPC, BH/CPC lozenge). The titre of the virus was expressed as TCID50/ml calculated with the Spearman-Kärber method. Outcomes. The faster virucidal effect in high concentration was seen in the combination BH/CPC as throat lozenge when compared to CPC as free active substance. A reduction of the virus concentration was seen, at 15 minutes contact, in all three concentrations. Conclusions. There is a strong virucidal effect a throat lozenge with fixed combination of cetylpyridinium chloride and benzydamine hydrochloride on the novel coronavirus.
{"title":"Direct virucidal effect of a throat lozenge with fixed combination of cetylpyridinium chloride and benzydamine hydrochloride on SARS-CoV-2 – in vitro study","authors":"C. Sarafoleanu, R. Enache","doi":"10.37897/rjphp.2021.3.3","DOIUrl":"https://doi.org/10.37897/rjphp.2021.3.3","url":null,"abstract":"Objectives. To evaluate the in vitro virucidal effect of the combination of cetylpyridinium chloride (CPC) and benzydamine hydrochloride (BH) as a throat lozenge against the novel SARS-CoV-2. Material and methods. The study evaluated the viral presence and titre in cell cultures by using SARS-CoV-2 virus incubated for 1, 5, 15 minutes, with three different concentrations of three different active substances (CPC, free BH/ CPC, BH/CPC lozenge). The titre of the virus was expressed as TCID50/ml calculated with the Spearman-Kärber method. Outcomes. The faster virucidal effect in high concentration was seen in the combination BH/CPC as throat lozenge when compared to CPC as free active substance. A reduction of the virus concentration was seen, at 15 minutes contact, in all three concentrations. Conclusions. There is a strong virucidal effect a throat lozenge with fixed combination of cetylpyridinium chloride and benzydamine hydrochloride on the novel coronavirus.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46806042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Benedec, Diana ROZSA (RUS), D. Hanganu, I. Oniga
Objectives. Ocimum basilicum is one of the widespread medicinal plants, widely used due to its multiple therapeutic properties (antimicrobial, antiviral, hypoglycemic, antispasmodic, anti-inflammatory, carminative, stomachic, antioxidant, analgesic, etc.), as well as its specific aromatic character. The aim of this study was to comparatively investigate the chemical composition (flavonoids, caffeic acid derivatives, tannins, essential oil) of the aerial parts of some Romanian medicinal teas of Ocimum basilicum. Materials and methods. The content of flavonoids, phenolic acids and tannins in three samples of O. basilicum tea were determined spectrophotometrically. Identification of important phenolic compounds (rutin, isoquercitrin chlorogenic acid and caffeic acid) was performed by thin layer chromatography (TLC). The essential oils were obtained by hydrodistillation method. Outcomes and conclusions. Following the quantitative determinations performed, it can be seen that the basil samples are rich in active principles, and their use for the treatment of some diseases can be justified.
{"title":"Chemical analysis of some Ocimum basilicum medicinal teas","authors":"D. Benedec, Diana ROZSA (RUS), D. Hanganu, I. Oniga","doi":"10.37897/rjphp.2021.3.6","DOIUrl":"https://doi.org/10.37897/rjphp.2021.3.6","url":null,"abstract":"Objectives. Ocimum basilicum is one of the widespread medicinal plants, widely used due to its multiple therapeutic properties (antimicrobial, antiviral, hypoglycemic, antispasmodic, anti-inflammatory, carminative, stomachic, antioxidant, analgesic, etc.), as well as its specific aromatic character. The aim of this study was to comparatively investigate the chemical composition (flavonoids, caffeic acid derivatives, tannins, essential oil) of the aerial parts of some Romanian medicinal teas of Ocimum basilicum. Materials and methods. The content of flavonoids, phenolic acids and tannins in three samples of O. basilicum tea were determined spectrophotometrically. Identification of important phenolic compounds (rutin, isoquercitrin chlorogenic acid and caffeic acid) was performed by thin layer chromatography (TLC). The essential oils were obtained by hydrodistillation method. Outcomes and conclusions. Following the quantitative determinations performed, it can be seen that the basil samples are rich in active principles, and their use for the treatment of some diseases can be justified.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44068365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandru Gâvan, Cătălina Bogdan, L. Rus, Paula Râșteiu, Ioana Toma, M. Achim, Sonia Iurian
Mannitol is used in freeze-dried products as a bulking agent, consistency enhancer, or stabilizer, having the lowest hygroscopicity among the excipients commonly used as consistency agents, therefore it can be used in the formulation of unstable preparations. Lyophilization is a complex method of drying a solution at low temperature and low-pressure that addresses especially thermolabile substances, such as proteins. The end-product is a lyophilized powder, which can be administered parenterally after reconstitution with suitable solvents. The objective of this study was to evaluate freeze-dried products obtained from mannitol solutions of different concentrations. Mannitol solutions of increasing concentrations of 2.5%, 5%, 7.5%, and 10% were prepared by dissolving mannitol in distilled water. The prepared solutions were freeze-dried after a preliminary DSC analysis, in which the thermal phenomena that occurred during lyophilization were identified. Freeze-dried preparations were analyzed by different methods: macroscopic analysis by visual assessment and comparison with data from the literature, texture analysis by which several properties of these preparations were studied (hardness, deformation, mechanical work, adhesive strength, fracture resistance, and the number of fractures), evaluation of reconstitution time and porosity. The mannitol used in the lyophilization process, being partially amorphous, required differential calorimetric analysis to establish its glass transition and to avoid the collapse of the preparations during lyophilization. Finally, NIR spectroscopy was used to predict the characteristics of the freeze-dried powders in a non-invasive manner, without prior sample preparation.
{"title":"NIR spectroscopy coupled with multivariate data analysis in the prediction of the characteristics of mannitol lyophilized cakes","authors":"Alexandru Gâvan, Cătălina Bogdan, L. Rus, Paula Râșteiu, Ioana Toma, M. Achim, Sonia Iurian","doi":"10.37897/rjphp.2021.3.4","DOIUrl":"https://doi.org/10.37897/rjphp.2021.3.4","url":null,"abstract":"Mannitol is used in freeze-dried products as a bulking agent, consistency enhancer, or stabilizer, having the lowest hygroscopicity among the excipients commonly used as consistency agents, therefore it can be used in the formulation of unstable preparations. Lyophilization is a complex method of drying a solution at low temperature and low-pressure that addresses especially thermolabile substances, such as proteins. The end-product is a lyophilized powder, which can be administered parenterally after reconstitution with suitable solvents. The objective of this study was to evaluate freeze-dried products obtained from mannitol solutions of different concentrations. Mannitol solutions of increasing concentrations of 2.5%, 5%, 7.5%, and 10% were prepared by dissolving mannitol in distilled water. The prepared solutions were freeze-dried after a preliminary DSC analysis, in which the thermal phenomena that occurred during lyophilization were identified. Freeze-dried preparations were analyzed by different methods: macroscopic analysis by visual assessment and comparison with data from the literature, texture analysis by which several properties of these preparations were studied (hardness, deformation, mechanical work, adhesive strength, fracture resistance, and the number of fractures), evaluation of reconstitution time and porosity. The mannitol used in the lyophilization process, being partially amorphous, required differential calorimetric analysis to establish its glass transition and to avoid the collapse of the preparations during lyophilization. Finally, NIR spectroscopy was used to predict the characteristics of the freeze-dried powders in a non-invasive manner, without prior sample preparation.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42834813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perception of beauty is tied to the idea of youth. This is why a large number of peptides proposed in the field of cosmetics are used as anti-aging/anti-wrinkle products. Some peptides have been proven in their efficacy through clinical skin trials. This paper describes some peptides that are most frequently used in cosmeceutical products and their potential benefits and practical use in dermatology.
{"title":"Antirid peptides in cosmeceutical formula","authors":"Gabriela Tătărîngă, A. Zbancioc","doi":"10.37897/rjphp.2021.3.1","DOIUrl":"https://doi.org/10.37897/rjphp.2021.3.1","url":null,"abstract":"Perception of beauty is tied to the idea of youth. This is why a large number of peptides proposed in the field of cosmetics are used as anti-aging/anti-wrinkle products. Some peptides have been proven in their efficacy through clinical skin trials. This paper describes some peptides that are most frequently used in cosmeceutical products and their potential benefits and practical use in dermatology.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44478215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives. The purpose of this paper was to evaluate the drug dispensing activity of analgesic opioids in pharmacies. Materials and methods. The study was conducted in an observational and retrospective manner, based on a questionnaire distributed in different pharmacies across Romania. Results. The dispensing activity of opioid analgesics is conducted in 71 out of the 100 pharmacies that have received the questionnaire. These pharmacies are located in 12 out of the 41 counties, mostly in the urban area and 96% of them are community pharmacies. The most prescribed and dispensed pharmaceutical forms are solid forms, the injectable products and transdermic systems being dispensed in a high percentage, up to 40% respectively, only in 25% of the questioned pharmacies. The average time spent by a pharmacist for the entire activity of dispensing an opioid analgesic prescribed by a doctor was estimated at 17.82± 0.58 minutes. Conclusions. The activity regarding opioid analgesics in the community pharmacy is limited by the low rentability, high costs and time consumption. The results of the study impose a further analysis on the impact that this service has upon public health, in order to this activity be sustained by the national health insurance system. Measures must be implemented to ensure that patients from rural or unprivileged areas are able to get their analgesics from the nearest community pharmacy constantly.
{"title":"Evaluating the activity of dispensing opioid analgesic medication","authors":"E. Dinte, Radu Borza, Oana MOCAN GURKA","doi":"10.37897/rjphp.2021.3.5","DOIUrl":"https://doi.org/10.37897/rjphp.2021.3.5","url":null,"abstract":"Objectives. The purpose of this paper was to evaluate the drug dispensing activity of analgesic opioids in pharmacies. Materials and methods. The study was conducted in an observational and retrospective manner, based on a questionnaire distributed in different pharmacies across Romania. Results. The dispensing activity of opioid analgesics is conducted in 71 out of the 100 pharmacies that have received the questionnaire. These pharmacies are located in 12 out of the 41 counties, mostly in the urban area and 96% of them are community pharmacies. The most prescribed and dispensed pharmaceutical forms are solid forms, the injectable products and transdermic systems being dispensed in a high percentage, up to 40% respectively, only in 25% of the questioned pharmacies. The average time spent by a pharmacist for the entire activity of dispensing an opioid analgesic prescribed by a doctor was estimated at 17.82± 0.58 minutes. Conclusions. The activity regarding opioid analgesics in the community pharmacy is limited by the low rentability, high costs and time consumption. The results of the study impose a further analysis on the impact that this service has upon public health, in order to this activity be sustained by the national health insurance system. Measures must be implemented to ensure that patients from rural or unprivileged areas are able to get their analgesics from the nearest community pharmacy constantly.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43726068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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