Abstract The most common childhood cancer is acute lymphoblastic leukemia, which, thanks to medical progress, achieves up to 95% of complete remission and 80% of cures with appropriate treatment among patients diagnosed with ALL. A less than three-year-old boy treated for an infectious disease and progressively worsening symptoms was transferred by the Emergency Department to the Department of Hematology and Oncology of Children after revealing leukocytosis and thrombocytopenia. In a short time, the child’s condition deteriorated, and it was decided to transfer the patient to the Children’s Intensive Care Unit. Due to respiratory failure, the boy was intubated, and mechanical ventilation was started. Catecholamines and sedatives were introduced. Due to increasing edema and anuria, diuretics were administered without diuresis. Hemodialysis was used. In spite of transfused group compatible blood products and exchange transfusion, coagulation disorders occurred. On the tenth day of hospitalization in the intensive care unit, the procedure of confirming brain death was performed. Both the prevention and treatment of hyperleukocytosis syndrome and the development of treatment methods do not reduce the risk of this syndrome among children diagnosed with acute lymphoblastic leukemia. The determination of permanent and irreversible cessation of brain function is possible only after the proper execution of the procedure for determining brain death.
{"title":"A Case Study of Child with Acute Lymphoblastic Leukemia Treated in Intensive Care","authors":"A. Król","doi":"10.2478/jhsm-2022-0003","DOIUrl":"https://doi.org/10.2478/jhsm-2022-0003","url":null,"abstract":"Abstract The most common childhood cancer is acute lymphoblastic leukemia, which, thanks to medical progress, achieves up to 95% of complete remission and 80% of cures with appropriate treatment among patients diagnosed with ALL. A less than three-year-old boy treated for an infectious disease and progressively worsening symptoms was transferred by the Emergency Department to the Department of Hematology and Oncology of Children after revealing leukocytosis and thrombocytopenia. In a short time, the child’s condition deteriorated, and it was decided to transfer the patient to the Children’s Intensive Care Unit. Due to respiratory failure, the boy was intubated, and mechanical ventilation was started. Catecholamines and sedatives were introduced. Due to increasing edema and anuria, diuretics were administered without diuresis. Hemodialysis was used. In spite of transfused group compatible blood products and exchange transfusion, coagulation disorders occurred. On the tenth day of hospitalization in the intensive care unit, the procedure of confirming brain death was performed. Both the prevention and treatment of hyperleukocytosis syndrome and the development of treatment methods do not reduce the risk of this syndrome among children diagnosed with acute lymphoblastic leukemia. The determination of permanent and irreversible cessation of brain function is possible only after the proper execution of the procedure for determining brain death.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124724814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnieszka Żegota, Urszula Papierz, A. Dudko, S. Kłosek
Abstract Background Depression is a common disorder among older adults, yet it is not a standard element of the aging process. Depression can affect oral health as a result of neglecting hygiene routines, poor nutrition, and avoiding necessary dental care, resulting in an increased risk of caries and periodontal disease. On the other hand, general health deteriorating with age and also poor oral health are not without their impact on mental state. Objectives The aim of this study was to assess the prevalence of depression and its association with oral problems in patients over 65 years of age using removable prosthetic restorations. Materials and methods Ninety-eight elderly patients (over 65 years of age) using removable prosthetic restorations were studied. The study variables included sociodemographic data (age, gender), and variables describing general health status included smoking and systemic diseases. The association of oral health parameters with depression was assessed using the following variables: missing teeth, duration of prosthetic restoration use, prosthetic inflammation, and dry mouth. Results Depression is significantly more frequently diagnosed among elderly patients (median age 72 years) with the evidence of a nervous system disease, denture wearers diagnosed with prosthetic ground inflammation, patients with dry mouth (according to the FOX test), and among patients using removable dentures for more than 10 years. Additionally, in the assessment of the risk of depression, age, cardiovascular disease, nervous system disease, duration of denture use of more than 10 years, prosthetic base inflammation and dry mouth according to the FOX test were found to statistically significantly increase the chance of developing depression. Conclusion The above data should be taken into account in the daily dental care of the elderly, and interdisciplinary care should be considered in elderly patients at risk of depression.
{"title":"Assessment of the Severity of Depressive Symptoms in Patients over 65 Years of Age Using Removable Dentures","authors":"Agnieszka Żegota, Urszula Papierz, A. Dudko, S. Kłosek","doi":"10.2478/jhsm-2022-0001","DOIUrl":"https://doi.org/10.2478/jhsm-2022-0001","url":null,"abstract":"Abstract Background Depression is a common disorder among older adults, yet it is not a standard element of the aging process. Depression can affect oral health as a result of neglecting hygiene routines, poor nutrition, and avoiding necessary dental care, resulting in an increased risk of caries and periodontal disease. On the other hand, general health deteriorating with age and also poor oral health are not without their impact on mental state. Objectives The aim of this study was to assess the prevalence of depression and its association with oral problems in patients over 65 years of age using removable prosthetic restorations. Materials and methods Ninety-eight elderly patients (over 65 years of age) using removable prosthetic restorations were studied. The study variables included sociodemographic data (age, gender), and variables describing general health status included smoking and systemic diseases. The association of oral health parameters with depression was assessed using the following variables: missing teeth, duration of prosthetic restoration use, prosthetic inflammation, and dry mouth. Results Depression is significantly more frequently diagnosed among elderly patients (median age 72 years) with the evidence of a nervous system disease, denture wearers diagnosed with prosthetic ground inflammation, patients with dry mouth (according to the FOX test), and among patients using removable dentures for more than 10 years. Additionally, in the assessment of the risk of depression, age, cardiovascular disease, nervous system disease, duration of denture use of more than 10 years, prosthetic base inflammation and dry mouth according to the FOX test were found to statistically significantly increase the chance of developing depression. Conclusion The above data should be taken into account in the daily dental care of the elderly, and interdisciplinary care should be considered in elderly patients at risk of depression.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132551970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agata Kunert, Dominika Cichońska-Rzeźnicka, Jan Krakowiak
Abstract Background The benefits of introducing specific procedures in a company have been proven. They systematize the work, increases the efficiency of the enterprise and employee productivity. They also allow the owners to reduce waste and maximize the company’s profits. The standard for improving quality in the enterprise presented by the International Organization for Standardization is the 9000: 2015 norm, it is the applicable standard. Possible barriers to the implementation of the procedures and quality improvement, such as ISO standards or accreditation for dental clinics, were assessed. The main barriers include the standards’ inadequacy to the size and structure of the facility, and thus the costs of its implementation are disproportionate to the benefits for dental clinics. Objective The aim of the study is to assess the demand for a holistic and cross-sectional quality management system in dental clinics in Poland and to create procedures adequate to the needs. Material and methods The research was carried out among the owners/managers of dental clinics in the Lodz Voivodeship and their employees: doctors, dental assistants/hygienists, medical recorders/patient caregivers. The tool applied was an anonymous questionnaire in an electronic form, intended for self-completion by respondents. The study began in June 2022 and continued until 215 questionnaires were collected from dental office employees and 39 questionnaires from owners and managers. The data was compiled using the Statistica software. Results The presented results clearly show the need for procedures and their standardization as well as quality improvements in dental offices. More than 66.5% of employees and 68.4% of dental offices’ owners point out a positive impact and the need to introduce procedures and improve quality. As many as 72% of employees believe that it would improve work efficiency. They also present the impact of procedures on safety at work, reduction of stress factors, as well as reduction of waste and maximization of profits. Conclusions The presented data clearly shows that there is a need for procedures and quality improvement, both among employees as well as owners and managers. Specific procedures allow to increase the level of employees’ security, ensure the quality of services provided and ameliorate the flow of information in the enterprise. All these benefits support the creation of a holistic and cross-sectional tool that would include all procedures and quality improvement that would systematize the work of dental offices.
{"title":"Quality Management in Dental Offices in the Lodz Voivodeship in the Opinion of the Facilities’ Employees and Owners","authors":"Agata Kunert, Dominika Cichońska-Rzeźnicka, Jan Krakowiak","doi":"10.36145/JHSM2022.08","DOIUrl":"https://doi.org/10.36145/JHSM2022.08","url":null,"abstract":"Abstract Background The benefits of introducing specific procedures in a company have been proven. They systematize the work, increases the efficiency of the enterprise and employee productivity. They also allow the owners to reduce waste and maximize the company’s profits. The standard for improving quality in the enterprise presented by the International Organization for Standardization is the 9000: 2015 norm, it is the applicable standard. Possible barriers to the implementation of the procedures and quality improvement, such as ISO standards or accreditation for dental clinics, were assessed. The main barriers include the standards’ inadequacy to the size and structure of the facility, and thus the costs of its implementation are disproportionate to the benefits for dental clinics. Objective The aim of the study is to assess the demand for a holistic and cross-sectional quality management system in dental clinics in Poland and to create procedures adequate to the needs. Material and methods The research was carried out among the owners/managers of dental clinics in the Lodz Voivodeship and their employees: doctors, dental assistants/hygienists, medical recorders/patient caregivers. The tool applied was an anonymous questionnaire in an electronic form, intended for self-completion by respondents. The study began in June 2022 and continued until 215 questionnaires were collected from dental office employees and 39 questionnaires from owners and managers. The data was compiled using the Statistica software. Results The presented results clearly show the need for procedures and their standardization as well as quality improvements in dental offices. More than 66.5% of employees and 68.4% of dental offices’ owners point out a positive impact and the need to introduce procedures and improve quality. As many as 72% of employees believe that it would improve work efficiency. They also present the impact of procedures on safety at work, reduction of stress factors, as well as reduction of waste and maximization of profits. Conclusions The presented data clearly shows that there is a need for procedures and quality improvement, both among employees as well as owners and managers. Specific procedures allow to increase the level of employees’ security, ensure the quality of services provided and ameliorate the flow of information in the enterprise. All these benefits support the creation of a holistic and cross-sectional tool that would include all procedures and quality improvement that would systematize the work of dental offices.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123471158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urszula Papierz, Agnieszka Żegota, A. Dudko, S. Kłosek
Abstract Background Elderly patients using removable dentures experience a number of oral problems associated with mucosal traumatisation and the consequences of poor oral hygiene, which affect the patients’ quality of life. Objectives The aim of this study was to assess the quality of life associated with the oral cavity in patients over 65 years of age who use removable dentures. Material and methods A group of 98 patients over 65 years of age who use removable dentures were examined with the GOHAI questionnaire. Demographic data, and information on smoking, the duration of denture use and the Fox test were also taken. The dental examination assessed the condition of the oral cavity, especially missing teeth, approximal plaque index API, gingival bleeding index SBI, and prosthetic base. Results Sperman correlation analysis showed statistically significant differences in several variables. A statistically significantly lower quality of life was found in patients who were edentulous, smoked cigarettes, had symptoms of dry mouth, prosthetic base inflammation and SBI above 50%. Conclusions Patients using removable dentures mostly lack good oral hygiene, which needs to be improved by increasing their awareness of the possible consequences of neglect. Dental care should take into account factors that affect patients’ quality of life.
{"title":"Quality of Life of Patients over 65 Years Old Who Use Removable Dentures","authors":"Urszula Papierz, Agnieszka Żegota, A. Dudko, S. Kłosek","doi":"10.36145/JHSM2022.09","DOIUrl":"https://doi.org/10.36145/JHSM2022.09","url":null,"abstract":"Abstract Background Elderly patients using removable dentures experience a number of oral problems associated with mucosal traumatisation and the consequences of poor oral hygiene, which affect the patients’ quality of life. Objectives The aim of this study was to assess the quality of life associated with the oral cavity in patients over 65 years of age who use removable dentures. Material and methods A group of 98 patients over 65 years of age who use removable dentures were examined with the GOHAI questionnaire. Demographic data, and information on smoking, the duration of denture use and the Fox test were also taken. The dental examination assessed the condition of the oral cavity, especially missing teeth, approximal plaque index API, gingival bleeding index SBI, and prosthetic base. Results Sperman correlation analysis showed statistically significant differences in several variables. A statistically significantly lower quality of life was found in patients who were edentulous, smoked cigarettes, had symptoms of dry mouth, prosthetic base inflammation and SBI above 50%. Conclusions Patients using removable dentures mostly lack good oral hygiene, which needs to be improved by increasing their awareness of the possible consequences of neglect. Dental care should take into account factors that affect patients’ quality of life.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114150535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karolina Mikut, A. Wijata, Joanna Osiak, K. Kędziora–Kornatowska
Abstract Introduction and objective The L-FODMAP diet limits products that contain hard-to-digest carbohydrates and other substances that may affect the symptoms of gastrointestinal diseases. The main objective is to eat foods with a low content of poorly absorbable carbohydrates that undergo fermentation and lead to an increase in osmotic pressure in the small and large intestine. This group includes lactose, fructose, polyhydroxy alcohols (mannitol, xylitol, sorbitol), galactooligosaccharides and fructans. The aim of this work is to review the available studies and to collect information on the use of the L-FODMAP diet in gastroenterological diseases. Abbreviated description of the state of knowledge Research results show that there are benefits of using the L-FODMAP diet in patients with irritable bowel syndrome – in the group of patients on a L-FODMAP diet there was a significant improvement in gastrointestinal symptoms as well as an improvement in quality of life. In the remission of inflammatory bowel diseases such as colitis ulcerosa and Crohn’s disease, a reduction of symptoms and an improvement in quality of life were also observed, a reduction of symptoms and an improvement in quality of life were also observed. There have been studies on the use of this diet in gastroesophageal reflux disease, but no hard evidence of its effectiveness has been found yet. Summary According to the results of recent studies, we can assume that the L-FODMAP diet can reduce troublesome ailments in some gastroenterological diseases. It is also important to remember that its use can lead to the elimination of many nutrients. There may also be a negative impact on motility and intestinal microbiota. More clinical trials are needed to provide more evidence for the use of the L-FODMAP diet in these disease entities.
{"title":"The Use and Efficacy of the Low FODMAP Diet in the Treatment of Gastrointestinal Diseases","authors":"Karolina Mikut, A. Wijata, Joanna Osiak, K. Kędziora–Kornatowska","doi":"10.36145/JHSM2022.11","DOIUrl":"https://doi.org/10.36145/JHSM2022.11","url":null,"abstract":"Abstract Introduction and objective The L-FODMAP diet limits products that contain hard-to-digest carbohydrates and other substances that may affect the symptoms of gastrointestinal diseases. The main objective is to eat foods with a low content of poorly absorbable carbohydrates that undergo fermentation and lead to an increase in osmotic pressure in the small and large intestine. This group includes lactose, fructose, polyhydroxy alcohols (mannitol, xylitol, sorbitol), galactooligosaccharides and fructans. The aim of this work is to review the available studies and to collect information on the use of the L-FODMAP diet in gastroenterological diseases. Abbreviated description of the state of knowledge Research results show that there are benefits of using the L-FODMAP diet in patients with irritable bowel syndrome – in the group of patients on a L-FODMAP diet there was a significant improvement in gastrointestinal symptoms as well as an improvement in quality of life. In the remission of inflammatory bowel diseases such as colitis ulcerosa and Crohn’s disease, a reduction of symptoms and an improvement in quality of life were also observed, a reduction of symptoms and an improvement in quality of life were also observed. There have been studies on the use of this diet in gastroesophageal reflux disease, but no hard evidence of its effectiveness has been found yet. Summary According to the results of recent studies, we can assume that the L-FODMAP diet can reduce troublesome ailments in some gastroenterological diseases. It is also important to remember that its use can lead to the elimination of many nutrients. There may also be a negative impact on motility and intestinal microbiota. More clinical trials are needed to provide more evidence for the use of the L-FODMAP diet in these disease entities.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133741795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrianna Nieciecka, A. Wójcik, Julia Tomys, K. Kędziora–Kornatowska, Magdalena Lamch, M. Janiszewska, M. Jabłońska, Natalia Błasik
Abstract Background Society in Poland and other developed countries is aging at an increasing rate, which is also reflected in the frequency of addiction among older people. This has social, health and economic implications, as older people are still active in the labor force today. Objectives The aim of this study is to review information on the problem of addiction to drugs, nicotine, alcohol and gambling in the elderly and to present the related difficulties in medical practice. Material and methods Review of publications on addiction among seniors included in the PubMed and Google Scholar database. The publications were collected between 2011–2021. Conclusions Addictions in older people are slightly different from addictions in younger age groups, so they should be considered separately. The elderly are particularly vulnerable to drug addiction. Seniors suffer from many chronic diseases; polypharmacy is often used to treat them. In addition, older people often struggle with insomnia and pain, which can lead to addiction to benzodiazepines and opioids. The physician plays a key role in the diagnosis and treatment of addiction in elderly patients, regardless of the type of addiction. In all cases of addiction, factors that predispose seniors to addiction should be taken into account. These are often modifiable factors, such as loneliness, a sense of rejection or inappropriate treatment of chronic diseases.
{"title":"Addictions in the Elderly – Review Article","authors":"Adrianna Nieciecka, A. Wójcik, Julia Tomys, K. Kędziora–Kornatowska, Magdalena Lamch, M. Janiszewska, M. Jabłońska, Natalia Błasik","doi":"10.36145/JHSM2022.10","DOIUrl":"https://doi.org/10.36145/JHSM2022.10","url":null,"abstract":"Abstract Background Society in Poland and other developed countries is aging at an increasing rate, which is also reflected in the frequency of addiction among older people. This has social, health and economic implications, as older people are still active in the labor force today. Objectives The aim of this study is to review information on the problem of addiction to drugs, nicotine, alcohol and gambling in the elderly and to present the related difficulties in medical practice. Material and methods Review of publications on addiction among seniors included in the PubMed and Google Scholar database. The publications were collected between 2011–2021. Conclusions Addictions in older people are slightly different from addictions in younger age groups, so they should be considered separately. The elderly are particularly vulnerable to drug addiction. Seniors suffer from many chronic diseases; polypharmacy is often used to treat them. In addition, older people often struggle with insomnia and pain, which can lead to addiction to benzodiazepines and opioids. The physician plays a key role in the diagnosis and treatment of addiction in elderly patients, regardless of the type of addiction. In all cases of addiction, factors that predispose seniors to addiction should be taken into account. These are often modifiable factors, such as loneliness, a sense of rejection or inappropriate treatment of chronic diseases.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131474453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Cichoń, Katarzyna Joanna Gąsior, Aleksandra Hincz, Katarzyna Anna Taran
Abstract Background Oxygen balance is critical for cell life and is regulated by an intricate oxygen-sensing process in the body. The same mechanism can also be used by cancer cells to survive, to grow and to disseminate what is key for cancer patients’ life. We took highly advanced interdisciplinary approach Isotope Ratio Mass Spectrometry to experimentally search for methodological issues fundamental for oxygen evaluation on an atomic level of cancer tissue biology – by stable isotope ratio assessment. Objectives The aim of presented studies was to assess the reference mass of the sample for oxygen estimation in future cancer tissue studies. Material and Methods Experimental O-isotope determination in animal tissues made by IRMS (Thermo Finnigan MAT 253) following pyrolysis at 1350°C and chromatographic separation (70°C) of H2 and CO in a He gas stream. Results Oxygen signals were identified in all the examined experimental animal tissue samples. The obtained oxygen isotope ratio values appeared 12,7 ± 0,5 ‰ and 11,8 ± 1,0/2 ‰ for vacuum line and the vacuum dryer experimental parts, appropriately. Conclusions Homogeneity of the tissue sample is critical for oxygen isotope ratio measurements in cancer. It must be taken in consideration when the level of homogenization of the sample allows to achieve the results versatile for cancer tissue studies with prospective clinical impact. Presented studies are the call for overcoming interdisciplinary barriers to intensify and develop isotope ratio cancer studies which give hope to understand more cancer disease and save cancer patients’ lives.
氧平衡对细胞生命至关重要，并受到体内复杂的氧感应过程的调节。同样的机制也可以被癌细胞用来生存、生长和传播对癌症患者生命至关重要的东西。我们采用高度先进的跨学科方法同位素比质谱法，通过稳定同位素比评估，在原子水平上对癌症组织生物学进行氧评估的基本方法问题进行实验研究。本研究的目的是评估样本的参考质量，以便在未来的癌症组织研究中进行氧估计。材料和方法用IRMS (Thermo Finnigan MAT 253)测定动物组织中o同位素的实验方法，该方法在1350°C下热解，在He气流中色谱分离H2和CO(70°C)。结果实验动物组织中均存在氧信号。真空管路和真空干燥机实验部件得到的氧同位素比值值分别为12.7±0.5‰和11.8±1.0 /2‰。结论:组织样品的均匀性对肿瘤氧同位素比值测量至关重要。当样品的均质化水平允许实现具有前瞻性临床影响的癌症组织研究的通用结果时，必须考虑到这一点。所提出的研究呼吁克服跨学科的障碍，加强和发展同位素癌症研究，为了解更多的癌症疾病和挽救癌症患者的生命带来希望。
{"title":"The First Pyrolysis Protocol Based on Experimental Measurements in the Atomic Level Structured Cancer Studies","authors":"M. Cichoń, Katarzyna Joanna Gąsior, Aleksandra Hincz, Katarzyna Anna Taran","doi":"10.36145/JHSM2022.01","DOIUrl":"https://doi.org/10.36145/JHSM2022.01","url":null,"abstract":"Abstract Background Oxygen balance is critical for cell life and is regulated by an intricate oxygen-sensing process in the body. The same mechanism can also be used by cancer cells to survive, to grow and to disseminate what is key for cancer patients’ life. We took highly advanced interdisciplinary approach Isotope Ratio Mass Spectrometry to experimentally search for methodological issues fundamental for oxygen evaluation on an atomic level of cancer tissue biology – by stable isotope ratio assessment. Objectives The aim of presented studies was to assess the reference mass of the sample for oxygen estimation in future cancer tissue studies. Material and Methods Experimental O-isotope determination in animal tissues made by IRMS (Thermo Finnigan MAT 253) following pyrolysis at 1350°C and chromatographic separation (70°C) of H2 and CO in a He gas stream. Results Oxygen signals were identified in all the examined experimental animal tissue samples. The obtained oxygen isotope ratio values appeared 12,7 ± 0,5 ‰ and 11,8 ± 1,0/2 ‰ for vacuum line and the vacuum dryer experimental parts, appropriately. Conclusions Homogeneity of the tissue sample is critical for oxygen isotope ratio measurements in cancer. It must be taken in consideration when the level of homogenization of the sample allows to achieve the results versatile for cancer tissue studies with prospective clinical impact. Presented studies are the call for overcoming interdisciplinary barriers to intensify and develop isotope ratio cancer studies which give hope to understand more cancer disease and save cancer patients’ lives.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114353646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction Smoking is defined as a chronic disease with periods of use and abstinence. Reducing tobacco consumption is of key importance to the overall health of the population. The combination of therapeutic education, behavioral support, and pharmacotherapy are key ingredients in smoking cessation. Clinical guidelines recommend cognitive-behavioral intervention together with the administration of first-line drugs (bupropion, varenicline, NRT). Interventions of as little as 3 minutes by primary care physicians can help patients to quit smoking successfully. Quitting smoking advice by GPs has been shown to increase rates of quitting smoking. Aim The aim of the study was to assess smoking cessation frequency and the frequency of smoking cessation counseling in primary care. Material and Methods A cross-sectional study was conducted in 2015 among 114 smokers from the Piotrków district who were referred to a primary care physician. The Bioethics Committee of the Medical University of Lodz issued a positive opinion on the study (RNN/243/15/KE). The research tool was a questionnaire. Results 57% of respondents had tried to quit smoking, the most common number of attempts being 1–2 (32.5% of respondents); 66.7% of respondents intended to quit smoking in the next month, and 22.8% were considering quitting smoking in the next 12 months; 45.6% of respondents had been advised to quit smoking in the last 12 months; and only 38.6% of respondents had ever been given advice on stopping smoking by their GP. In the previous 12 months: 14.9% of respondents had used nicotine replacement therapy, incl. slices or chewing gum; 3.5% of people had benefited from therapeutic help, including the anti-smoking clinic; 3.5% of respondents had used traditional drugs (e.g., champix); and 5.3% of respondents had used prescription drugs (e.g., bupropion). Conclusions The results suggest that the time spent advising patients on smoking should include helping them to quit smoking. GPs should discuss smoking cessation with more patients who smoke.
{"title":"Using Professional Support when Quitting Smoking Original Publication","authors":"M. Znyk, Ewa Siwińska-Beck","doi":"10.36145/JHSM2022.05","DOIUrl":"https://doi.org/10.36145/JHSM2022.05","url":null,"abstract":"Abstract Introduction Smoking is defined as a chronic disease with periods of use and abstinence. Reducing tobacco consumption is of key importance to the overall health of the population. The combination of therapeutic education, behavioral support, and pharmacotherapy are key ingredients in smoking cessation. Clinical guidelines recommend cognitive-behavioral intervention together with the administration of first-line drugs (bupropion, varenicline, NRT). Interventions of as little as 3 minutes by primary care physicians can help patients to quit smoking successfully. Quitting smoking advice by GPs has been shown to increase rates of quitting smoking. Aim The aim of the study was to assess smoking cessation frequency and the frequency of smoking cessation counseling in primary care. Material and Methods A cross-sectional study was conducted in 2015 among 114 smokers from the Piotrków district who were referred to a primary care physician. The Bioethics Committee of the Medical University of Lodz issued a positive opinion on the study (RNN/243/15/KE). The research tool was a questionnaire. Results 57% of respondents had tried to quit smoking, the most common number of attempts being 1–2 (32.5% of respondents); 66.7% of respondents intended to quit smoking in the next month, and 22.8% were considering quitting smoking in the next 12 months; 45.6% of respondents had been advised to quit smoking in the last 12 months; and only 38.6% of respondents had ever been given advice on stopping smoking by their GP. In the previous 12 months: 14.9% of respondents had used nicotine replacement therapy, incl. slices or chewing gum; 3.5% of people had benefited from therapeutic help, including the anti-smoking clinic; 3.5% of respondents had used traditional drugs (e.g., champix); and 5.3% of respondents had used prescription drugs (e.g., bupropion). Conclusions The results suggest that the time spent advising patients on smoking should include helping them to quit smoking. GPs should discuss smoking cessation with more patients who smoke.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127199370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paulina Trawka, Milena Kwietniewska, M. Falkowski, K. Kędziora–Kornatowska
Abstract Introduction Atrial fibrillation is a common arrhythmia in the elderly population, which may lead to thromboembolic events complicated by ischemic stroke. The frequency increases with age along with other chronic diseases such as diabetes or hypertension. Non-vitamin K antagonist oral anticoagulants (NOACs) are the main drugs used in the prevention of stroke, taking the place of vitamin K antagonists (VKAs). Materials and Methods The article reviews the literature using the Pubmed and Google Scholar databases. Articles were analyzed using keywords: atrial fibrillation, elderly, NOAC, VKA, ischemic stroke. Results Many studies have shown that NOACs are a groundbreaking achievement in treating thromboembolic events such as ischemic stroke, even in the elderly. Their efficiency and safety surpasses VKAs as they have better pharmacokinetics and pharmacodynamics along with a wider therapeutic index, no need for monitoring, less risk of interactions and fatal bleeding, but with higher risk of gastrointestinal bleeding. Conclusion NOACs are efficient and safe in the elderly with atrial fibrillation for ischemic stroke prevention. Caution should be kept in patients with renal failure or a prosthetic valve. Interactions are not serious but possible when taking NOACs with drugs such as carbamazepine. Investigation is still indicated for reviewing this issue further.
{"title":"Safety and Efficacy of Using NOAC as Prevention of Ischemic Stroke in the Geriatric Population with Atrial Fibrillation – Review Article","authors":"Paulina Trawka, Milena Kwietniewska, M. Falkowski, K. Kędziora–Kornatowska","doi":"10.36145/JHSM2022.04","DOIUrl":"https://doi.org/10.36145/JHSM2022.04","url":null,"abstract":"Abstract Introduction Atrial fibrillation is a common arrhythmia in the elderly population, which may lead to thromboembolic events complicated by ischemic stroke. The frequency increases with age along with other chronic diseases such as diabetes or hypertension. Non-vitamin K antagonist oral anticoagulants (NOACs) are the main drugs used in the prevention of stroke, taking the place of vitamin K antagonists (VKAs). Materials and Methods The article reviews the literature using the Pubmed and Google Scholar databases. Articles were analyzed using keywords: atrial fibrillation, elderly, NOAC, VKA, ischemic stroke. Results Many studies have shown that NOACs are a groundbreaking achievement in treating thromboembolic events such as ischemic stroke, even in the elderly. Their efficiency and safety surpasses VKAs as they have better pharmacokinetics and pharmacodynamics along with a wider therapeutic index, no need for monitoring, less risk of interactions and fatal bleeding, but with higher risk of gastrointestinal bleeding. Conclusion NOACs are efficient and safe in the elderly with atrial fibrillation for ischemic stroke prevention. Caution should be kept in patients with renal failure or a prosthetic valve. Interactions are not serious but possible when taking NOACs with drugs such as carbamazepine. Investigation is still indicated for reviewing this issue further.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116155339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalia Kasprzyk, P. Poniewierski, A. Kostiukow, W. Samborski
Abstract Rheumatoid arthritis (RA) is an autoimmune chronic systemic connective tissue disease characterized by symmetrical arthritis, abarticular changes and systemic symptoms. The most characteristic symptoms are pain, stiffness and symmetrical swelling in the joints. Including nutritional treatment in RA patients as a permanent component of therapy may have benefits in terms of weight regulation, reducing the risk of cardiovascular disease and osteoporosis, and an overall improvement in the patient’s quality of life. Chemical compounds that exhibit anti-inflammatory effects include polyunsaturated fatty acids, polyphenols, and antioxidants. The use of herbal raw materials with anti-inflammatory properties is also becoming popular, but there is a need for further analysis to create official recommendations. Studies analysing the effect of consumption of anti-inflammatory bioactive substances on the disease activity have contributed to the search for a specific nutritional model optimal for patients with RA. Due to the high supply of anti-inflammatory substances and protective nature against the development of cardiovascular diseases, a balanced diet based on the principles of the Mediterranean diet is recommended. The aim of this review was to present the current knowledge on the role of diet in rheumatoid arthritis including the effect of bioactive substances supplementation on disease activity.
{"title":"The Role of Diet in Rheumatoid Arthritis Therapy – A Review of the Literature","authors":"Natalia Kasprzyk, P. Poniewierski, A. Kostiukow, W. Samborski","doi":"10.36145/JHSM2022.02","DOIUrl":"https://doi.org/10.36145/JHSM2022.02","url":null,"abstract":"Abstract Rheumatoid arthritis (RA) is an autoimmune chronic systemic connective tissue disease characterized by symmetrical arthritis, abarticular changes and systemic symptoms. The most characteristic symptoms are pain, stiffness and symmetrical swelling in the joints. Including nutritional treatment in RA patients as a permanent component of therapy may have benefits in terms of weight regulation, reducing the risk of cardiovascular disease and osteoporosis, and an overall improvement in the patient’s quality of life. Chemical compounds that exhibit anti-inflammatory effects include polyunsaturated fatty acids, polyphenols, and antioxidants. The use of herbal raw materials with anti-inflammatory properties is also becoming popular, but there is a need for further analysis to create official recommendations. Studies analysing the effect of consumption of anti-inflammatory bioactive substances on the disease activity have contributed to the search for a specific nutritional model optimal for patients with RA. Due to the high supply of anti-inflammatory substances and protective nature against the development of cardiovascular diseases, a balanced diet based on the principles of the Mediterranean diet is recommended. The aim of this review was to present the current knowledge on the role of diet in rheumatoid arthritis including the effect of bioactive substances supplementation on disease activity.","PeriodicalId":335287,"journal":{"name":"Journal of Health Study and Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129890321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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