Pub Date : 2022-06-15DOI: 10.46347/jmsh.v8i1.21.61
P. Jha, Narendra Singh Ranawat, R. Ranjan, R. Ahmed, R. Avasthi, A. Ahirwar
Objective: The metabolic syndrome (MetS) may be responsible for occurrence of high frequency of cardiovascular disease in rheumatoid arthritis (RA) patients. An association between inflammatory activity of RA and MetS has also been speculated. This study was designed to see whether presence of MetS along with RA increases the severity of disease and to find the risk association of the disease severity markers of RA namely TNF-α, anti-CCP, RF, CRP and ESR with MetS. Methodology: 185 patients of RA (EULAR 2010) were recruited and assessed for MetS according to NCEP/ATP III criteria. Serum level of disease specific biomarkers of RA namely TNF-α, anti-CCP, RF, CRP and ESR were quantified in all patients and compared between RA with MetS and only RA patients. Cytokine TNF-α, anti-CCP, RF, and CRP were assayed through ELISA. Results: The prevalence of MetS among RA patients was 41.2%. The mean age of RA cases with MetS is significantly older (55.65yrs) with increased disease duration. The levels of TNF-α, anti-CCP, CRP and ESR along with EULAR & DAS score were significantly (p<0.05) high in RA with MetS. TNF-α showed maximum risk (OR=6.3; p=0.03) in development of MetS. Longer disease duration with high anti-CCP, CRP and DAS-28 were also contributing significantly in MetS development. Conclusion: A positive vicious cycle is working between the pathogenesis of RA and MetS through inflammatory cytokines and biomarkers. MetS in RA is associated with increased disease severity. Keywords: Rheumatoid arthritis, Metabolic syndrome, Biomarkers, Cytokine TNF-α, Disease severity
{"title":"Interrelationship of Metabolic Syndrome and Rheumatoid Arthritis in North Indian Population","authors":"P. Jha, Narendra Singh Ranawat, R. Ranjan, R. Ahmed, R. Avasthi, A. Ahirwar","doi":"10.46347/jmsh.v8i1.21.61","DOIUrl":"https://doi.org/10.46347/jmsh.v8i1.21.61","url":null,"abstract":"Objective: The metabolic syndrome (MetS) may be responsible for occurrence of high frequency of cardiovascular disease in rheumatoid arthritis (RA) patients. An association between inflammatory activity of RA and MetS has also been speculated. This study was designed to see whether presence of MetS along with RA increases the severity of disease and to find the risk association of the disease severity markers of RA namely TNF-α, anti-CCP, RF, CRP and ESR with MetS. Methodology: 185 patients of RA (EULAR 2010) were recruited and assessed for MetS according to NCEP/ATP III criteria. Serum level of disease specific biomarkers of RA namely TNF-α, anti-CCP, RF, CRP and ESR were quantified in all patients and compared between RA with MetS and only RA patients. Cytokine TNF-α, anti-CCP, RF, and CRP were assayed through ELISA. Results: The prevalence of MetS among RA patients was 41.2%. The mean age of RA cases with MetS is significantly older (55.65yrs) with increased disease duration. The levels of TNF-α, anti-CCP, CRP and ESR along with EULAR & DAS score were significantly (p<0.05) high in RA with MetS. TNF-α showed maximum risk (OR=6.3; p=0.03) in development of MetS. Longer disease duration with high anti-CCP, CRP and DAS-28 were also contributing significantly in MetS development. Conclusion: A positive vicious cycle is working between the pathogenesis of RA and MetS through inflammatory cytokines and biomarkers. MetS in RA is associated with increased disease severity. Keywords: Rheumatoid arthritis, Metabolic syndrome, Biomarkers, Cytokine TNF-α, Disease severity","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44231763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.46347/jmsh.2022.v8i1.20
Shulbha V. Sejekan, D. Biligi
Background: Skin is a complex organ composed of epidermis, dermis and skin adnexa producing multitude of tumors. The skin adnexal neoplasms are classified into sub-groups, depending on their differentiation towards hair follicles, sebaceous, apocrine and eccrine glands. Clinically adnexal neoplasm presents as asymptomatic papules or nodules, having non-specific morphological appearance and therefore histopathology is the gold standard for their confirmatory diagnosis. The aim is to assess clinico-histopathological characteristic features of the skin lesions, subtype and to pick up certain subtle features that clinch the diagnosis towards their line of differentiation. Methods: The study has been conducted in the Department of Pathology, for a period of one year. The total numbers of cases with histopathological diagnosis of skin adnexal lesions are 105. Ethical clearance for the same has been obtained by the Head of Institution. Skin biopsy specimen are received and processed in the histokinette; paraffin embedded blocks made and stained with Hematoxylin & Eosin stain. Special stains when required have been used. Descriptive statistics have been used in analysis of the results. Result: The total number of cases with histopathological diagnosis of skin adnexal lesions is 105. Among them 99/105 cases (94.3%) are benign and malignant counterparts comprised of 6/105 cases (5.7%).Overall lesions with hair follicle differentiation comprised of 73.3% (77/105), followed by sebaceous differentiation of 15.3% (16/105) and eccrine differentiation of 11.4 % (12/105). Conclusion: This study emphasized that histopathological examination, plays an essential role in studying the skin adnexal tumors, owing to its indistinctive clinical presentation. Keywords: Adnexal, Eccrine, Skin, Tumor, Sebaceous, Apocrine
{"title":"Clinicopathological Study of Skin Adnexal Tumors with Special Emphasis on the Line of Differentiation","authors":"Shulbha V. Sejekan, D. Biligi","doi":"10.46347/jmsh.2022.v8i1.20","DOIUrl":"https://doi.org/10.46347/jmsh.2022.v8i1.20","url":null,"abstract":"Background: Skin is a complex organ composed of epidermis, dermis and skin adnexa producing multitude of tumors. The skin adnexal neoplasms are classified into sub-groups, depending on their differentiation towards hair follicles, sebaceous, apocrine and eccrine glands. Clinically adnexal neoplasm presents as asymptomatic papules or nodules, having non-specific morphological appearance and therefore histopathology is the gold standard for their confirmatory diagnosis. The aim is to assess clinico-histopathological characteristic features of the skin lesions, subtype and to pick up certain subtle features that clinch the diagnosis towards their line of differentiation. Methods: The study has been conducted in the Department of Pathology, for a period of one year. The total numbers of cases with histopathological diagnosis of skin adnexal lesions are 105. Ethical clearance for the same has been obtained by the Head of Institution. Skin biopsy specimen are received and processed in the histokinette; paraffin embedded blocks made and stained with Hematoxylin & Eosin stain. Special stains when required have been used. Descriptive statistics have been used in analysis of the results. Result: The total number of cases with histopathological diagnosis of skin adnexal lesions is 105. Among them 99/105 cases (94.3%) are benign and malignant counterparts comprised of 6/105 cases (5.7%).Overall lesions with hair follicle differentiation comprised of 73.3% (77/105), followed by sebaceous differentiation of 15.3% (16/105) and eccrine differentiation of 11.4 % (12/105). Conclusion: This study emphasized that histopathological examination, plays an essential role in studying the skin adnexal tumors, owing to its indistinctive clinical presentation. Keywords: Adnexal, Eccrine, Skin, Tumor, Sebaceous, Apocrine","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44536069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.46347/jmsh.2022.v8i1.8
Kaushik Ishore, Ghosh Prabir, A. Mukherjee, Santanu Hazra
Background: Incidence of hospital-acquired infection by Methicillin-resistant Staphylococcus aureus (MRSA) and Coagulase-negative Staphylococci (MRCoNS) continues to increase worldwide. Nasal carriage of Staphylococci plays an important role in the epidemiology and pathogenesis of hospital-acquired infection. They are usually introduced into the health care set up by a colonized or infected patient or health care workers (HCWs). Patients admitted to a critical care unit or intensive care unit have an increased chance of infection by these pathogens. Health care providers colonizing MRSA and MRCoNS may help in the transmission and spread of infection. Objective: To determine the prevalence of staphylococcal nasal carriage among HCWs working in intensive and critical care units of a tertiary care hospital and the antimicrobial susceptibility profile of the isolates. Result: One hundred and fifty nasal swabs were collected, 58 were from the nursing staff, 41 from doctors, and 51 were from other supporting staff. Samples from both anterior nares were collected using sterile cotton swabs, and cultured on mannitol salt agar. S. aureus and CoNS were identified by standard methods. Methicillin resistance was detected by cefoxitin disc. Of the 150 healthcare providers screened 31 (20.67%) were nasal carriers of S. aureus, 17 (11.33%) for MRSA, 81 (54%) harbored CoNS and 12 (8%) were MRCoNS. Conclusion: HCWs are the potential colonizers of MRSA and MRCoNS. They may serve as reservoirs and disseminators of MRSA and MRCoNS and should be treated with appropriate drugs. Regular screening of carriers is also required for the prevention of hospital-acquired infection. Keywords: Nasal Carriers, Health care worker, Methicillinresistant Staphylococcus
{"title":"Prevalence of Staphylococcal Nasal Carriage Among Health Care Worker Working in Intensive and Critical Care Units of a Tertiary Care Hospital","authors":"Kaushik Ishore, Ghosh Prabir, A. Mukherjee, Santanu Hazra","doi":"10.46347/jmsh.2022.v8i1.8","DOIUrl":"https://doi.org/10.46347/jmsh.2022.v8i1.8","url":null,"abstract":"Background: Incidence of hospital-acquired infection by Methicillin-resistant Staphylococcus aureus (MRSA) and Coagulase-negative Staphylococci (MRCoNS) continues to increase worldwide. Nasal carriage of Staphylococci plays an important role in the epidemiology and pathogenesis of hospital-acquired infection. They are usually introduced into the health care set up by a colonized or infected patient or health care workers (HCWs). Patients admitted to a critical care unit or intensive care unit have an increased chance of infection by these pathogens. Health care providers colonizing MRSA and MRCoNS may help in the transmission and spread of infection. Objective: To determine the prevalence of staphylococcal nasal carriage among HCWs working in intensive and critical care units of a tertiary care hospital and the antimicrobial susceptibility profile of the isolates. Result: One hundred and fifty nasal swabs were collected, 58 were from the nursing staff, 41 from doctors, and 51 were from other supporting staff. Samples from both anterior nares were collected using sterile cotton swabs, and cultured on mannitol salt agar. S. aureus and CoNS were identified by standard methods. Methicillin resistance was detected by cefoxitin disc. Of the 150 healthcare providers screened 31 (20.67%) were nasal carriers of S. aureus, 17 (11.33%) for MRSA, 81 (54%) harbored CoNS and 12 (8%) were MRCoNS. Conclusion: HCWs are the potential colonizers of MRSA and MRCoNS. They may serve as reservoirs and disseminators of MRSA and MRCoNS and should be treated with appropriate drugs. Regular screening of carriers is also required for the prevention of hospital-acquired infection. Keywords: Nasal Carriers, Health care worker, Methicillinresistant Staphylococcus","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44618509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.46347/jmsh.v8i1.21.168
A. Singh, Aatish Saraswat
The ongoing COVID-19 pandemic plaguing countries worldwide has created an unprecedented change for the global economy, especially healthcare institutions at the forefront. Acceleration of the online-offline integration is the need of the hour. Massive expansion of home-based care likely will be supplemented with artificial intelligence (AI). One particular sector that has the greatest potential to benefit from tele-health services is the rural sector across all countries. Telemedicine has shown to improve access to healthcare in these populations through a reduction in travel burden and decreased cost of care. Innovative arrangements between the private and the public sectors and digitalization are more crucial now than ever before. The digital media will play a rather more important role in connecting with prospective patients. Thus, as we unravel the mysteries of the ongoing pandemic there are opportunities in the future offering unique learning opportunities for the health care sector. Rationalizing and optimizing available resources with resilience shown on the coronavirus frontline during the crisis are some of the most important lessons learnt during the crisis Keywords: COVID-19, Clinical Practice, Telemedicine.
{"title":"Long Term Impact of COVID-19 on Clinical Practice","authors":"A. Singh, Aatish Saraswat","doi":"10.46347/jmsh.v8i1.21.168","DOIUrl":"https://doi.org/10.46347/jmsh.v8i1.21.168","url":null,"abstract":"The ongoing COVID-19 pandemic plaguing countries worldwide has created an unprecedented change for the global economy, especially healthcare institutions at the forefront. Acceleration of the online-offline integration is the need of the hour. Massive expansion of home-based care likely will be supplemented with artificial intelligence (AI). One particular sector that has the greatest potential to benefit from tele-health services is the rural sector across all countries. Telemedicine has shown to improve access to healthcare in these populations through a reduction in travel burden and decreased cost of care. Innovative arrangements between the private and the public sectors and digitalization are more crucial now than ever before. The digital media will play a rather more important role in connecting with prospective patients. Thus, as we unravel the mysteries of the ongoing pandemic there are opportunities in the future offering unique learning opportunities for the health care sector. Rationalizing and optimizing available resources with resilience shown on the coronavirus frontline during the crisis are some of the most important lessons learnt during the crisis Keywords: COVID-19, Clinical Practice, Telemedicine.","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42935314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malnutrition in the elderly has been associated with deleterious effects on health care outcomes such as functional decline, cognitive impairment, depression, increased hospital stays, and increased morbidity and mortality. This cross-sectional study aims to determine the association of malnutrition with functional status and cognition and duration of hospitalization among 200 elderly patients admitted to medical wards of a tertiary care hospital in India. The nutritional screening was done using Mini Nutritional assessment- short form (MNA-SF). The functional activity was assessed using the Barthel’s Index. Cognitive assessment and screening for depression was done using the Mini-cog test and Geriatric Depression score – 4 respectively. Descriptive analyses were used to estimate the prevalence of malnutrition and associations were assessed using the Pearson chi square test. Among the total patients, 136 (68%) were malnourished. Of these, 45 (22.5%) were severely undernourished. The malnourished patients had poorer functional scores (p<0.001), were likely to be cognitively impaired (33%, 45 of 136) (p < 0.001) and stayed longer in the hospital (n= 9.13 days) compared to the normally nourished. The nutritional status of hospitalized elderly may therefore serve as a surrogate marker of disability and poor clinical outcome. Keywords: Malnutrition, Geriatric, Nutritional assessment, Undernourishment, Functional decline, Elderly
{"title":"Malnutrition in Elderly - A Predictor of Cognitive, Functional Decline, Depression and Prolonged Hospital Stay","authors":"Steve Manjaly, S. Sebastian, Arun Alex","doi":"10.46347/jmsh.v8i1.21.5","DOIUrl":"https://doi.org/10.46347/jmsh.v8i1.21.5","url":null,"abstract":"Malnutrition in the elderly has been associated with deleterious effects on health care outcomes such as functional decline, cognitive impairment, depression, increased hospital stays, and increased morbidity and mortality. This cross-sectional study aims to determine the association of malnutrition with functional status and cognition and duration of hospitalization among 200 elderly patients admitted to medical wards of a tertiary care hospital in India. The nutritional screening was done using Mini Nutritional assessment- short form (MNA-SF). The functional activity was assessed using the Barthel’s Index. Cognitive assessment and screening for depression was done using the Mini-cog test and Geriatric Depression score – 4 respectively. Descriptive analyses were used to estimate the prevalence of malnutrition and associations were assessed using the Pearson chi square test. Among the total patients, 136 (68%) were malnourished. Of these, 45 (22.5%) were severely undernourished. The malnourished patients had poorer functional scores (p<0.001), were likely to be cognitively impaired (33%, 45 of 136) (p < 0.001) and stayed longer in the hospital (n= 9.13 days) compared to the normally nourished. The nutritional status of hospitalized elderly may therefore serve as a surrogate marker of disability and poor clinical outcome. Keywords: Malnutrition, Geriatric, Nutritional assessment, Undernourishment, Functional decline, Elderly","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45070352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.46347/jmsh.v8i1.21.107
R. Jyothi, B. Manjula, K. Gurupadappa
Background: Several studies have suggested that hepatic and renal abnormalities are seen in COVID-19 patients. So in this study; we are evaluating the hepatic, renal and inflammatory bio-makers in mild and severe group of COVID-19 patients. Objective: To evaluate and compare the hepatic, renal and some inflammatory biomarkers in mild and severe group of COVID-19 patients. Methods: It was a single-centric retrospective study. This study included a total number of 199 RT-PCR confirmedCOVID-19 patients. These patients were divided into the mild group (n=96) and severe group (n=103) depending on the requirement of intensive care unit. We evaluated and compared the hepatic, renal and some inflammatory biomarkers between the mild and severe groups. Statistical analysis was done using a statistical package for the social sciences (SPSS). Results: Out of 199 cases, 68.3% were male and 31.7% were female. The mean age of the study population was found to be 52.4±14.6 years. Statistically, a significant difference at 5%(p=0.001) was observed for creatinine, urea, direct bilirubin, ferritin, aspartate amino-transferase, total protein, and albumin levels between the mild and severe group except for uric acid, total bilirubin, alanine-transaminase, alkaline phosphatase and lactate dehydrogenase. Conclusion: Our study shows hepatic and renal abnormalities are observed in COVID-19 infection. However, the percentage of hepatic and renal abnormalities was more in the severe group compared to the mild group. Further extensive studies should be carried out with a larger population with multi-centric studies in Karnataka. Keywords: COVID-19, Hepatic, Renal
{"title":"Comparison of Hepatic, Renal and Inflammatory Biochemical Parameters in Mild and Severe Covid-19 Patients","authors":"R. Jyothi, B. Manjula, K. Gurupadappa","doi":"10.46347/jmsh.v8i1.21.107","DOIUrl":"https://doi.org/10.46347/jmsh.v8i1.21.107","url":null,"abstract":"Background: Several studies have suggested that hepatic and renal abnormalities are seen in COVID-19 patients. So in this study; we are evaluating the hepatic, renal and inflammatory bio-makers in mild and severe group of COVID-19 patients. Objective: To evaluate and compare the hepatic, renal and some inflammatory biomarkers in mild and severe group of COVID-19 patients. Methods: It was a single-centric retrospective study. This study included a total number of 199 RT-PCR confirmedCOVID-19 patients. These patients were divided into the mild group (n=96) and severe group (n=103) depending on the requirement of intensive care unit. We evaluated and compared the hepatic, renal and some inflammatory biomarkers between the mild and severe groups. Statistical analysis was done using a statistical package for the social sciences (SPSS). Results: Out of 199 cases, 68.3% were male and 31.7% were female. The mean age of the study population was found to be 52.4±14.6 years. Statistically, a significant difference at 5%(p=0.001) was observed for creatinine, urea, direct bilirubin, ferritin, aspartate amino-transferase, total protein, and albumin levels between the mild and severe group except for uric acid, total bilirubin, alanine-transaminase, alkaline phosphatase and lactate dehydrogenase. Conclusion: Our study shows hepatic and renal abnormalities are observed in COVID-19 infection. However, the percentage of hepatic and renal abnormalities was more in the severe group compared to the mild group. Further extensive studies should be carried out with a larger population with multi-centric studies in Karnataka. Keywords: COVID-19, Hepatic, Renal","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45437032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.46347/jmsh.v8i1.21.48
Pallavi K Gedam, S. Chawhan, S. S. Chawhan, Manish L Pandhare
Context: The lesions of nasal cavity and paranasal sinuses provides problem in their diagnosis, prognosis and management because of limited anatomical space and certain unusual clinicopathological features. Aims: The present study was undertaken to study the incidence & frequency of various non-neoplastic and neoplastic lesions. It also aimed to describe the histomorphologic features of lesions of nasal cavity and paranasal sinuses. Settings and Design: This is a simple retrospective observational study. Methods and Materials: The material for present study was obtained as excisional biopsy of the lesions. The specimens were received in 10% formalin along with requisition form which also included the clinical data. The material was processed as routine histopathological examination. Special stains were done wherever required. Results: Total 62 cases were analyzed. The lesions were classified as non-neoplastic and neoplastic. The non-neoplastic lesions were classified according to classification given by Friedman and Osborn. Tumors of nasal cavity and paranasal sinus were classified according to WHO classification and observations compared with other studies. Conclusions: Non-neoplastic lesions were more common than neoplastic lesions. Sinonasal polyps were the most common lesions in the present study (50%). The age incidence ranges from 1st decade to 7th decade. There was slight female preponderance. The incidence of malignant tumours was slightly more than the benign tumours. Thus categorizing the sinonasal lesions according to histopathological features into various types helps clinicians to know the clinical presentation, the best management, clinical outcome and prognosis of the disease. Keywords: Histopathology, Nasal, paranasal, Sinonasal, Polyp, WHO
{"title":"Histopathological Study of Lesions of Nasal Cavity and Paranasal Sinuses","authors":"Pallavi K Gedam, S. Chawhan, S. S. Chawhan, Manish L Pandhare","doi":"10.46347/jmsh.v8i1.21.48","DOIUrl":"https://doi.org/10.46347/jmsh.v8i1.21.48","url":null,"abstract":"Context: The lesions of nasal cavity and paranasal sinuses provides problem in their diagnosis, prognosis and management because of limited anatomical space and certain unusual clinicopathological features. Aims: The present study was undertaken to study the incidence & frequency of various non-neoplastic and neoplastic lesions. It also aimed to describe the histomorphologic features of lesions of nasal cavity and paranasal sinuses. Settings and Design: This is a simple retrospective observational study. Methods and Materials: The material for present study was obtained as excisional biopsy of the lesions. The specimens were received in 10% formalin along with requisition form which also included the clinical data. The material was processed as routine histopathological examination. Special stains were done wherever required. Results: Total 62 cases were analyzed. The lesions were classified as non-neoplastic and neoplastic. The non-neoplastic lesions were classified according to classification given by Friedman and Osborn. Tumors of nasal cavity and paranasal sinus were classified according to WHO classification and observations compared with other studies. Conclusions: Non-neoplastic lesions were more common than neoplastic lesions. Sinonasal polyps were the most common lesions in the present study (50%). The age incidence ranges from 1st decade to 7th decade. There was slight female preponderance. The incidence of malignant tumours was slightly more than the benign tumours. Thus categorizing the sinonasal lesions according to histopathological features into various types helps clinicians to know the clinical presentation, the best management, clinical outcome and prognosis of the disease. Keywords: Histopathology, Nasal, paranasal, Sinonasal, Polyp, WHO","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42600615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Dehury, H. Das, Abhipsa Patra, Rashmita Pradhan
Irritable Bowel Syndrome (IBS) is a functional bowel disorder characterized by abdominal pain or discomfort and altered bowel habits in absence of detectable structural abnormalities with worldwide incidence of 10-20%. According to Rome IV criteria subtypes of IBS can be IBS-D, IBS-C and IBS-M. Both non pharmacological and pharmacological therapy are available for IBS. Earlier Peppermint Oil (PO) was used in different types of abdominal pain. An oral formulation of PO is used in patients of IBS to improve symptoms. Hence the study was conducted to assess the efficacy of Peppermint Oil in IBS patients.METHOD: A prospective randomized, placebo-controlled study of 6month was done in Dept. of Pharmacology and Gastroenterology, SCBMCH, Cuttack. A total of 60 IBS patients(18-60yr) were included in the study. They were divided randomly into two groups by lottery system. Gr-1 received PO 180mg TDS 60 min before breakfast, lunch, dinner and Gr-2 received placebo. The baseline and follow-up parameters of Total IBS symptom Score (TISS) were recorded at 0hr, 24hr and 4wks of treatment in both groups and Pain was assessed using Numeric Rating Scale. Statistical analysis were done using Mann-Whitney Test and Wilcoxon signed ranked Test. RESULTS: There was significant reduction in TISS and PAIN score at 24hr and 4weeks with Peppermint Oil from the baseline with Placebo.CONCLUSION : Peppermint oil was found to be effective in IBS patients. Keywords: Irritable Bowel Syndrome, Peppermint Oil, Total IBS symptom score, Numeric Pain rating scale
{"title":"Efficacy of Peppermint Oil in Irritable Bowel Syndrome","authors":"S. Dehury, H. Das, Abhipsa Patra, Rashmita Pradhan","doi":"10.46347/jmsh.v8i1.21.7","DOIUrl":"https://doi.org/10.46347/jmsh.v8i1.21.7","url":null,"abstract":"Irritable Bowel Syndrome (IBS) is a functional bowel disorder characterized by abdominal pain or discomfort and altered bowel habits in absence of detectable structural abnormalities with worldwide incidence of 10-20%. According to Rome IV criteria subtypes of IBS can be IBS-D, IBS-C and IBS-M. Both non pharmacological and pharmacological therapy are available for IBS. Earlier Peppermint Oil (PO) was used in different types of abdominal pain. An oral formulation of PO is used in patients of IBS to improve symptoms. Hence the study was conducted to assess the efficacy of Peppermint Oil in IBS patients.METHOD: A prospective randomized, placebo-controlled study of 6month was done in Dept. of Pharmacology and Gastroenterology, SCBMCH, Cuttack. A total of 60 IBS patients(18-60yr) were included in the study. They were divided randomly into two groups by lottery system. Gr-1 received PO 180mg TDS 60 min before breakfast, lunch, dinner and Gr-2 received placebo. The baseline and follow-up parameters of Total IBS symptom Score (TISS) were recorded at 0hr, 24hr and 4wks of treatment in both groups and Pain was assessed using Numeric Rating Scale. Statistical analysis were done using Mann-Whitney Test and Wilcoxon signed ranked Test. RESULTS: There was significant reduction in TISS and PAIN score at 24hr and 4weeks with Peppermint Oil from the baseline with Placebo.CONCLUSION : Peppermint oil was found to be effective in IBS patients. Keywords: Irritable Bowel Syndrome, Peppermint Oil, Total IBS symptom score, Numeric Pain rating scale","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48099332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.46347/jmsh.v8i1.21.125
P. Panicker, T. Iype
Background: Sonologic evaluation of the median nerve has been shown to be a useful tool in carpal tunnel syndrome diagnosis. Neurosonology supplants clinical and electrodiagnostic work up. Objectives: To determine the median nerve ultrasound parameters in carpal tunnel syndrome (CTS) patients and find their correlation with patient reported clinical data and electrophysiology findings,to assess diagnostic accuracy of nerve ultrasound in CTS in comparison to clinical evaluation combined with electrodiagnosis as reference standard. Methods: 23 consecutive patients with carpal tunnel syndrome symptoms (46 wrists-35 with nerve conduction study confirmed CTS, 11 without CTS) underwent neurosonologic evaluation with high resolution ultrasound including median nerve cross sectional area(CSA) at carpal tunnel inlet, flattening ratio, Wrist/forearm CSA ratio measurements. Patient reported measures were recorded using Boston carpal tunnel syndrome questionnaire (BCTQ). Results: Statistically significant correlation was found between median nerve CSA at carpal tunnel inlet and disease severity assessed by electrodiagnosis (r=0.545, p value-0.002), hand function status had significant correlation with electrodiagnostic severity class (r=0.422, p value 0.012). Flattening ratio, Wrist/forearm CSA ratio did not show significant correlation with clinical and electrophysiology measures. Sensitivity and specificity for a cross sectional area cut off of 9 cm2 for diagnosis of CTS was found to be 85.7 percent and 64 percent respectively. Conclusion: Median nerve cross sectional area CSA measurement is the most useful neurosonologic parameter and correlates with electrodiagnostic severity. Ultrasound is a useful complementary tool for CTS diagnosis, assessment alongside electrodiagnosis. Keywords: Carpal Tunnel Syndrome, Neurosonology, Compression neuropathy
{"title":"Nerve Ultrasound Findings in Carpal Tunnel Syndrome and its Correlation with Clinical and Electrophysiological Data","authors":"P. Panicker, T. Iype","doi":"10.46347/jmsh.v8i1.21.125","DOIUrl":"https://doi.org/10.46347/jmsh.v8i1.21.125","url":null,"abstract":"Background: Sonologic evaluation of the median nerve has been shown to be a useful tool in carpal tunnel syndrome diagnosis. Neurosonology supplants clinical and electrodiagnostic work up. Objectives: To determine the median nerve ultrasound parameters in carpal tunnel syndrome (CTS) patients and find their correlation with patient reported clinical data and electrophysiology findings,to assess diagnostic accuracy of nerve ultrasound in CTS in comparison to clinical evaluation combined with electrodiagnosis as reference standard. Methods: 23 consecutive patients with carpal tunnel syndrome symptoms (46 wrists-35 with nerve conduction study confirmed CTS, 11 without CTS) underwent neurosonologic evaluation with high resolution ultrasound including median nerve cross sectional area(CSA) at carpal tunnel inlet, flattening ratio, Wrist/forearm CSA ratio measurements. Patient reported measures were recorded using Boston carpal tunnel syndrome questionnaire (BCTQ). Results: Statistically significant correlation was found between median nerve CSA at carpal tunnel inlet and disease severity assessed by electrodiagnosis (r=0.545, p value-0.002), hand function status had significant correlation with electrodiagnostic severity class (r=0.422, p value 0.012). Flattening ratio, Wrist/forearm CSA ratio did not show significant correlation with clinical and electrophysiology measures. Sensitivity and specificity for a cross sectional area cut off of 9 cm2 for diagnosis of CTS was found to be 85.7 percent and 64 percent respectively. Conclusion: Median nerve cross sectional area CSA measurement is the most useful neurosonologic parameter and correlates with electrodiagnostic severity. Ultrasound is a useful complementary tool for CTS diagnosis, assessment alongside electrodiagnosis. Keywords: Carpal Tunnel Syndrome, Neurosonology, Compression neuropathy","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49643790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.46347/jmsh.v8i1.21.43
Siddharth Biswas, Dhruba Borpatragohain, C. Thoumoung
Background: Pulmonary tuberculosis is one of the most common infectious disease in developing country like India. Due to delay in diagnosis causes extensive lung damages leading to increased morbidity in patients. Objective: The aim of the study is to evaluate the various patterns of HRCT findings in cases of sputum positive pulmonary TB. In our study, findings of HRCT thorax of 50 patients of sputum positive pulmonary tuberculosis are studied retrospectively. Result & Conclusion: Consolidation was the most common HRCT finding in these patients. These patients also showed other patterns such as tree in bud opacities, ill-defined patchy opacities, cavities, bronchiectasis etc. Additional features like pleural effusion, pneumothorax, tubercular spondylitis are also seen in many patients. HRCT thorax is a useful investigation modality used to diagnose as well as for follow up of patients. Keywords: Consolidation, Cavity, Bronchiectasis
{"title":"Findings of HRCT Thorax in Patients of Sputum Positive Pulmonary Tuberculosis in a Tertiary Health Care Centre of North East India","authors":"Siddharth Biswas, Dhruba Borpatragohain, C. Thoumoung","doi":"10.46347/jmsh.v8i1.21.43","DOIUrl":"https://doi.org/10.46347/jmsh.v8i1.21.43","url":null,"abstract":"Background: Pulmonary tuberculosis is one of the most common infectious disease in developing country like India. Due to delay in diagnosis causes extensive lung damages leading to increased morbidity in patients. Objective: The aim of the study is to evaluate the various patterns of HRCT findings in cases of sputum positive pulmonary TB. In our study, findings of HRCT thorax of 50 patients of sputum positive pulmonary tuberculosis are studied retrospectively. Result & Conclusion: Consolidation was the most common HRCT finding in these patients. These patients also showed other patterns such as tree in bud opacities, ill-defined patchy opacities, cavities, bronchiectasis etc. Additional features like pleural effusion, pneumothorax, tubercular spondylitis are also seen in many patients. HRCT thorax is a useful investigation modality used to diagnose as well as for follow up of patients. Keywords: Consolidation, Cavity, Bronchiectasis","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48711942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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