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Mystical experience occasioned by non-medicinal embodied therapy And integration process for mental well-Being 由非药物具体化治疗引起的神秘体验和心理健康的整合过程
Pub Date : 2022-12-22 DOI: 10.15406/ipmrj.2022.07.00323
B. W. Meleski
Expansion of psychoactive hallucinogens in mental health continues to be a major trend. Several psychoactive molecules including psilocybin and MDMA continue to move through the FDA approval process with clinical trials.1 In the meantime, off-label ketamine medically supervised programs and indigenous plant ceremonies continue to expand.2,3 This study explores the potential benefits of High Intensity Embodied Stimulation (HIES) which is part of the Body Logic Program (10–12 sessions), and its ability to mimic psychoactive states of mind.4 The study employs a questionnaire of mystical experience, developed at Johns Hopkins, the Mystical Experience Questionnaire (MEQ), that assesses mystical experiences in seven domains. Fifty-six participants who finished the Body Logic Program, completed the questionnaire. Comparative data from Psilocybin participants, post psilocybin, as well as a placebo group (non-psilocybin) provide reference data.5,6 Results show that 51% of HIES participants report a strong or extreme mystical experience. Another 31% of HIES participants report a moderate strength of mystical experience. Results suggest that Body Logic Program can provide an efficacious system for mystical experience and body-mind integration.
精神活性致幻剂在精神卫生领域的扩大仍然是一个主要趋势。包括裸盖菇素和MDMA在内的几种精神活性分子继续通过FDA的临床试验批准程序与此同时,标签外氯胺酮医学监督项目和本土植物仪式继续扩大。2、3本研究探讨了高强度具身刺激(HIES)的潜在益处,它是身体逻辑计划(10-12次)的一部分,以及它模拟精神活动状态的能力这项研究采用了一份由约翰霍普金斯大学开发的神秘体验问卷,即神秘体验问卷(MEQ)来评估七个领域的神秘体验。56名完成身体逻辑程序的参与者完成了问卷调查。来自裸盖菇素参与者、裸盖菇素后以及安慰剂组(非裸盖菇素)的比较数据提供了参考数据。结果显示,51%的HIES参与者报告了强烈或极端的神秘体验。另有31%的HIES参与者报告了中等强度的神秘体验。结果表明,身体逻辑程序可以为神秘体验和身心整合提供一个有效的系统。
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引用次数: 0
Disfunctions in teaching the language and culture of anscents with the use of educational games 教育游戏在古人语言文化教学中的功能障碍
Pub Date : 2022-12-20 DOI: 10.15406/ipmrj.2022.07.00322
Monika Olędzka
Multimodality appearing in design: About ourselves and the peculiarities of Siedlce and Edmonton. What connects and what distinguishes our countries? shows the diverse paths which education follows. The multidimensionality invites students to be active, to develop their language skills, to use new technologies helpful in building dialogue between Poles and Polish Canadians. Through cooperation in the project people discovered their small homelands. By interacting in the project, they became ambassadors of Polishness. The article uses the method of document analysis, observation and case study.
在设计中出现的多模态:关于我们自己和Siedlce和Edmonton的特点。是什么将我们两国联系在一起?展示了教育遵循的不同路径。多维度邀请学生积极参与,发展他们的语言技能,使用有助于建立波兰人和波兰裔加拿大人之间对话的新技术。通过在项目中的合作,人们发现了他们的小家园。通过在项目中的互动,他们成为了波兰的大使。本文采用文献分析法、观察法和个案研究法。
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引用次数: 0
Stemness of breast cancer cells incubated on viscoelastic gel substrates 粘弹性凝胶基质培养乳腺癌细胞的干性
Pub Date : 2022-12-02 DOI: 10.15406/ipmrj.2022.07.00320
R. Sasaki, Ryohei Ohta, M. Okamoto
Acrylamide copolymer-based gel substrates with different viscoelasticity were employed to evaluate the viscoelasticity effect on the direct relation among cancer stemness and mesenchymal properties with induction of epithelial–mesenchymal transition (EMT) of human breast adenocarcinoma (MCF-7) cells in both normoxia and hypoxia. The softer gel substrate produced a large amount of surface molecule of cancer stem cells (CSC) marker CD44. In contrast, for the stem cell biomarker CD133 expression, their coefficient of damping (tan)-dependent manner was not contributed by EMT phenomenon and was an independent from acquisition of the EMT. The substrate damping as potential physical parameter emerged the important linkage to cancer stemness and EMT induction.
采用不同粘弹性的丙烯酰胺共聚物凝胶底物,研究黏弹性对人乳腺腺癌(MCF-7)细胞在常氧和低氧条件下上皮-间质转化(EMT)的诱导与癌干性和间质性质的直接关系。较软的凝胶底物产生了大量的肿瘤干细胞(CSC)标志物CD44的表面分子。相比之下,对于干细胞生物标志物CD133的表达,其阻尼系数(tan -)依赖方式不受EMT现象的影响,并且独立于EMT的获取。基底阻尼作为一种潜在的物理参数,成为影响肿瘤发生和EMT诱导的重要因素。
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引用次数: 0
Homozygosis variant p.asn115* in the ANO10 gene: a new discovered cause of spinocerebellar Ataxia ANO10基因的纯合变异p.asn115*:脊髓小脑性共济失调的新发现病因
Pub Date : 2022-11-28 DOI: 10.15406/ipmrj.2022.07.00319
Iria Beltrán Rodríguez, A. Arés Luque, Laura García-Talavera Casado
The spinocerebellar ataxia recessive type 10 is a genetic form associated with ANO10 gene mutations. Affected individuals present with ataxia, hyperreflexia, ocular movement disorders and cerebellar atrophy. The homozygous variant in the ANO10 gene NP_060545.3:p.Asn114* is a 2-nucleotide deletion that would cause the introduction of a premature stop codon at the same position, that has not been previously described in the scientific literature related to disease and it perfectly explains our patient’s condition.
脊髓小脑性共济失调隐性10型是一种与ANO10基因突变相关的遗传形式。患者表现为共济失调、反射亢进、眼运动障碍和小脑萎缩。ANO10基因的纯合变异体NP_060545.3:p。Asn114*是一个2个核苷酸的缺失,会导致在相同位置引入一个过早的终止密码子,这在之前与疾病相关的科学文献中没有描述过,它完美地解释了我们患者的病情。
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引用次数: 0
Buried bumper syndrome, a rare and severe complication of percutaneous endoscopic gastrostomy: importance of early diagnosis in poststroke patients 埋藏缓冲器综合征是经皮内镜胃造口术中一种罕见而严重的并发症:卒中后患者早期诊断的重要性
Pub Date : 2022-11-14 DOI: 10.15406/ipmrj.2022.07.00317
A. Ribeiro, Daniela Alves, Filipe Ermida, S. Moreira, Sandra Assunçãoira, João Constantino, J. Laíns
Introduction: Percutaneous Endoscopic Gastrostomy (PEG) is considered a low-risk procedure; however, side effects may happen, the majority being of mild severity. Among the severe complications, few cases entitled “Buried bumper syndrome” (BBS) have been described. BBS corresponds to the migration of the internal fixation along the stoma tract, becoming lodged between the external wall of the stomach and the skin, which can be associated with local infection, peritonitis, and/or necrotizing fasciitis. Case description: On 06/03/2021 at 29 years old male patient, with no relevant medical history is admitted to the São João Hospital with an extensive midbrain and brainstem hemorrhagic lesion, shown on CT scan. The patient lost his oral route and ability to communicate. Due to severe dysphagia, a PEG was placed without immediate complications. 3 days later, the nursing team reported peri-stomal food losses and local inflammation, with the patient unable to verbalize any complaint. Although there was an adjustment of the PEG by the gastroenterologist, these reports recur for the next week, being detected by the medical team after a routine full body evaluation of the patient. After a new evaluation, a CT was performed, reporting “PEG, whose balloon is located between the median abdominal wall and the anterior surface of the left hepatic lobe”, compatible with the complication described as “buried bumper syndrome”. Discussion: The present case emphasizes the importance of correctly identifying the complications after undergoing PEG, as well as the risk factors and consequences associated with this syndrome, namely in patients with post-stroke status, whose communication is often compromised, and special attention must be given
经皮内镜胃造口术(PEG)被认为是一种低风险的手术;然而,副作用可能会发生,大多数是轻微的严重程度。在严重的并发症中,被称为“埋藏保险杠综合征”(BBS)的病例很少被报道。BBS对应于内固定沿造口道移动,卡在胃外壁和皮肤之间,可伴有局部感染、腹膜炎和/或坏死性筋膜炎。病例描述:2021年3月6日,29岁男性患者,无相关病史,因CT扫描显示广泛的中脑和脑干出血性病变入住 o jo医院。病人失去了说话的途径和交流的能力。由于严重的吞咽困难,在没有立即并发症的情况下放置了PEG。3天后,护理小组报告患者口周食物丢失和局部炎症,患者无法用语言表达任何抱怨。虽然胃肠病学家对PEG进行了调整,但这些报告在接下来的一周内再次出现,由医疗小组在对患者进行常规全身评估后发现。重新评估后,行CT检查,报告“PEG,其球囊位于腹壁正中和左肝叶前表面之间”,符合“埋藏保险杠综合征”的并发症。讨论:本病例强调了正确识别PEG术后并发症的重要性,以及与该综合征相关的危险因素和后果,即卒中后状态的患者,其沟通往往受到损害,必须给予特别关注
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引用次数: 0
Study on the efficacy of harmonic frequencies applied through music therapy intervention techniques in cochlear implant patients 音乐治疗干预技术应用于人工耳蜗患者谐波频率的疗效研究
Pub Date : 2022-11-02 DOI: 10.15406/ipmrj.2022.07.00316
A. Hernández Fuentes, José Fernando Fernández Company
This article deals with research conducted through therapeutic intervention to three people with cochlear implants from 2016 to 2021, in which the effectiveness of music therapy as a tool in the auditory rehabilitation of cochlear implant patients was studied, not only for the improvement in the perception of music and its elements but also because it contributes to the development of oral language comprehension post-implant and improves the quality of life indices of these patients. For this purpose, the auditory rehabilitation techniques carried out in speech therapy were adapted to sound-musical activities in a structured and progressive manner. The results obtained indicate that the three patients achieved a good development in the activities and that they improved their levels of frequency and phonological discrimination as well as their language comprehension and perception in their quality of life.
本文通过2016年至2021年对3名人工耳蜗患者进行治疗性干预的研究,研究了音乐治疗作为一种工具在人工耳蜗患者听觉康复中的有效性,不仅是为了改善对音乐及其要素的感知,还因为它有助于人工耳蜗患者植入后口语理解的发展,提高患者的生活质量指标。为此,在语言治疗中进行的听觉康复技术以结构化和渐进的方式适应声音音乐活动。结果表明,3例患者在活动方面均有较好的发展,在频率和语音辨别水平、语言理解和感知能力等方面均有提高,生活质量得到改善。
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引用次数: 0
Post COVID community based self-care management of disabling osteoarthritis: importance and possible targeted needs 基于社区的失能性骨关节炎自我护理管理:重要性和可能的针对性需求
Pub Date : 2022-10-28 DOI: 10.15406/ipmrj.2022.07.00314
R. Marks
Background: Osteoarthritis, a highly common, disabling joint disease affecting a large number of older adults is presently incurable, and not always amenable to surgery or pharmacologic interventions. Purpose: Further complicated by multiple past and ongoing COVID-19 pandemic issues and disease consequences, the purpose was to examine what current data reveal as to the prevailing epidemiological features of osteoarthritis and its pathology. Another was to review the utility of some non-pharmacological and non-operative treatment strategies that have been advocated for alleviating the pain and disability of this disease in later life. Methods: Building on a 35 year prior review conducted in 2015, this current review was conducted to identify relevant literature published on this topic over the last 5 years, particularly since COVID-19 onset in 2019. Key words included osteoarthritis, COVID-19, prevention, and intervention. Results: As in prior years, osteoarthritis continues to induce considerable physical disability and consistently impedes the attainment of a high life quality for many older adults. Although not studied to any degree, COVID-19 factors may be expected to render further challenges that compound the disease presentation and its mitigation over time, especially among the long COVID affected older adult. In the face of closures, limited resources, and complex disease presentations, it does appear a variety of non-operative and non-pharmacologic approaches may yet influence the disease process and functional outcomes more positively than not with low safety risks. They may help the older adult more effectively even if surgery is indicated and multiple medications are yet required. Conclusion: The application of one or more carefully designed conservative interventions is likely to reduce the functional disability and pain experienced by older people with any form of osteoarthritis, regardless of whether surgical and or pharmacologic strategies are indicated.
背景:骨关节炎是一种非常常见的致残性关节疾病,影响大量老年人,目前无法治愈,并不总是适合手术或药物干预。目的:由于过去和现在的多个COVID-19大流行问题和疾病后果进一步复杂化,目的是检查当前数据揭示的骨关节炎及其病理的流行病学特征。另一个是回顾一些非药物和非手术治疗策略的效用,这些策略被提倡在以后的生活中减轻这种疾病的疼痛和残疾。方法:本综述以2015年进行的35年既往综述为基础,确定了过去5年,特别是2019年COVID-19发病以来发表的相关文献。关键词:骨关节炎,COVID-19,预防和干预。结果:与前几年一样,骨关节炎继续引起相当大的身体残疾,并持续阻碍许多老年人实现高生活质量。尽管尚未进行任何程度的研究,但预计COVID-19因素可能会带来进一步的挑战,使疾病的表现和缓解随着时间的推移变得更加复杂,特别是在长期受COVID影响的老年人中。面对封闭、有限的资源和复杂的疾病表现,各种非手术和非药物方法可能对疾病过程和功能结果产生积极的影响,而安全性风险较低。它们可以更有效地帮助老年人,即使需要手术和多种药物治疗。结论:一种或多种精心设计的保守干预措施的应用可能会减少任何形式骨关节炎老年人的功能障碍和疼痛,无论是否需要手术或药物治疗。
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引用次数: 0
The effects of extracorporeal shock wave therapy on hemineglect following a stroke. A case report study 体外冲击波治疗对脑卒中后半忽视的影响。个案报告研究
Pub Date : 2022-10-26 DOI: 10.15406/ipmrj.2022.07.00315
Irem Onin, H. Kumru, Monserrat Bernabeu, G. Lucente
Extracorporeal shock wave therapy (ESWT) is a non-invasive repetitive peripheral mechanical stimulation and might promote neuroplasticity in hemineglect syndrome. Two out of 15 patients with hemi spatial neglect following chronic stroke were completed the inclusion criterions and underwent one session of sham (placebo) and then one session of real ESWT. Both of the cases responded successfully to the ESWT by diminishing the neglect symptoms in comparison to their baseline evaluation, which maintained during one week of follow up evaluation session, but we did not observe changes in hemineglect syndrome in sham group. Our data showed that ESWT could be considered a promising tool in the treatment of neglect syndrome, however further studies are needed to confirm the effectiveness of ESWT.
体外冲击波治疗(ESWT)是一种非侵入性的重复性外周机械刺激,可能促进半忽视综合征的神经可塑性。15例慢性脑卒中后半空间忽视患者中有2例完成了纳入标准,并进行了一次假(安慰剂)和一次真实ESWT。与基线评估相比,这两个病例都成功地通过减少忽视症状对ESWT做出了反应,这在一周的随访评估期间保持不变,但我们没有观察到假手术组半忽视综合征的变化。我们的数据显示,ESWT可以被认为是治疗忽视综合征的一个很有前途的工具,但需要进一步的研究来证实ESWT的有效性。
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引用次数: 0
Nanoeduparemiological perspectives on HIV-AIDS HIV-AIDS的纳米教育病理学观点
Pub Date : 2022-10-06 DOI: 10.15406/ipmrj.2022.07.00313
Dito Anurogo
{"title":"Nanoeduparemiological perspectives on HIV-AIDS","authors":"Dito Anurogo","doi":"10.15406/ipmrj.2022.07.00313","DOIUrl":"https://doi.org/10.15406/ipmrj.2022.07.00313","url":null,"abstract":"","PeriodicalId":336722,"journal":{"name":"International Physical Medicine & Rehabilitation Journal","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114925121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of balance exercises and some physiotherapy methods to rehabilitate an ankle sprain for football players in Libya (Almarg) 使用平衡练习和一些物理治疗方法来恢复利比亚足球运动员的脚踝扭伤(Almarg)
Pub Date : 2022-10-03 DOI: 10.15406/ipmrj.2022.07.00312
Ay Omar, Fawzi Khattab
{"title":"The use of balance exercises and some physiotherapy methods to rehabilitate an ankle sprain for football players in Libya (Almarg)","authors":"Ay Omar, Fawzi Khattab","doi":"10.15406/ipmrj.2022.07.00312","DOIUrl":"https://doi.org/10.15406/ipmrj.2022.07.00312","url":null,"abstract":"","PeriodicalId":336722,"journal":{"name":"International Physical Medicine & Rehabilitation Journal","volume":"3 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117341510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Physical Medicine & Rehabilitation Journal
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