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Relative Efficacy of Virtual and In-Office Conservative Care for Musculoskeletal Conditions: A Propensity Score Matching Comparison Study (Preprint) 虚拟和办公室保守护理对肌肉骨骼疾病的相对疗效:倾向评分匹配比较研究(预印本)
Pub Date : 2022-01-17 DOI: 10.2196/preprints.36139
H. Elliott, E. S. Moll, E. Olmsted
BACKGROUND Propensity Score Matching is a statistical technique which allows an observational study to control for differences in the study and comparison group, without the difficulty of establishing a long-term randomized trial. This method is very appropriate to the evolving field of telemedicine, due to the fast pace at which it is proceeding and the limitations on data imposed by its relatively recent popularization. These limitations prevent a randomized controlled trial from being applied to most questions, creating a strong case for the use of Propensity Score Matching. OBJECTIVE To evaluate the relative efficacy of digital and in-person physical therapy in a single clinic while controlling for the different patient circumstances that may affect the choice of treatment option. METHODS We used propensity score matching to construct a cohort of 890 patients split evenly between digital and onsite patients. We matched patients on injury location, instance of injury (first, second, third, etc.), reported pain level on presentation, age, presence or absence of prior treatment attempts, gender, and BMI (for weight-bearing injury locations only). We evaluated the matched cohorts in upper and lower body groups for differences in patient reported pain improvement, visit completion, avoidance of surgeries, and patient reported injury resolution. RESULTS We analyzed that data using a two-one-sided T-test. We found that upper body digital patients perform equivalent to within 0.5 standard deviations or superior to in-person patients on all metrics (p < 0.05 for all metrics). Lower body digital and in-person patients performed within 0.5 standard deviations on visit completion, avoidance of surgeries, and reported injury resolution. (p <0.05.) Results for pain improvement were inconclusive, with the 95% confidence range indicating a possibility of either equivalent performance (p = 0.48) or inferior performance for digital patients (p = 0.52). CONCLUSIONS The date indicates an equivalent or superior performance for remote treatment of upper body injuries, with data suggesting improved visit completion improves other metrics more than any disadvantages of digital treatment can reduce them. Data regarding lower body injuries is inconclusive, due to high varied level of pain reduction experienced by patients. In light of other data on lower body patients, this suggests that further research may be able to assess which lower body injuries can and cannot be successfully treated via remote physical therapy.
倾向评分匹配是一种统计技术,它允许观察性研究控制研究组和对照组的差异,而没有建立长期随机试验的困难。这种方法非常适合不断发展的远程医疗领域,因为它的发展速度很快,而且它的普及相对较晚,对数据有限制。这些限制阻碍了随机对照试验应用于大多数问题,为使用倾向得分匹配创造了强有力的案例。目的在控制可能影响治疗方案选择的不同患者情况的情况下,评价单个诊所数字和面对面物理治疗的相对疗效。方法采用倾向评分匹配的方法,构建了890例患者的队列,平均分为数字患者和现场患者。我们根据损伤部位、损伤情况(第一次、第二次、第三次等)、报告的疼痛程度、年龄、是否有治疗尝试、性别和BMI(仅针对负重损伤部位)对患者进行匹配。我们评估了上半身组和下半身组的匹配队列在患者报告的疼痛改善、就诊完成、避免手术和患者报告的损伤解决方面的差异。结果我们采用双单侧t检验对数据进行分析。我们发现上半身数码患者在所有指标上的表现相当于0.5个标准差以内或优于面对面患者(所有指标p < 0.05)。下半身数字和面对面患者在访问完成、避免手术和报告损伤解决方面的表现在0.5个标准差内。(p < 0.05)。疼痛改善的结果尚无定论,95%的置信范围表明,数字患者可能表现相同(p = 0.48)或表现较差(p = 0.52)。结论:该数据表明远程治疗上肢损伤具有同等或更好的性能,数据表明,提高就诊完成率可以改善其他指标,而数字治疗的任何缺点都不能减少这些指标。由于患者经历的疼痛减轻程度各不相同,关于下体损伤的数据尚无定论。根据下半身患者的其他数据,这表明进一步的研究可能能够评估哪些下半身损伤可以通过远程物理治疗成功治疗,哪些不能。
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引用次数: 0
Level of uncertainty in people living with HIV 艾滋病毒感染者的不确定程度
Pub Date : 2019-02-12 DOI: 10.15406/ipmrj.2019.04.00170
Gerardo Saucedo Pahua, Mayra Itzel Huerta Baltazar, Ma. Lilia Alcántar Zavala, Ma de Jesús Ruiz Recéndiz, Vanesa Jiménez Arroyo, Rafaela Andrade Herrera
Introduction: Worldwide, human immunodeficiency virus (HIV) infection continues to be an emerging public health problem. With the positive screening of this chronic degenerative disease, the virus generates physical, psychological, social and spiritual changes in people, that lead to uncertainty in the face of an uncertain future. Identifying the uncertainty in the patients, allows the care professional to plan integral interventions to favour the reduction of this process and can integrate well-being in the experience with their chronic condition and thus, have quality of life. Objective: To determine the level of uncertainty in a group of people living with HIV. Method: Quantitative, descriptive and transversal study. Non-probabilistic sampling of 30 people living with HIV, from the CONVIHVE Civil Association of Morelia, Michoacán. An identification card and the scale “Uncertainty in front of the disease” (MUIS) of Merle Mishel were applied, with a reliability of (.904). The statistical package SPSS V was used to analyze the data. 22. Results: 83.3% of the total population are men and 16.7% are women, 32-39 years of age (36.6%) of whom 70% are men. Being single, 53.3% have a bachelor’s degree. 60% report being employed. 30% of the population refers to having more than 10 years of diagnosis and less than 5 years in treatment 53.3%. 76.7% are Catholic. From the total of participants, 23.3% showed a low level of uncertainty, followed by a level of regular uncertainty with 26.7%, and 50% showed a high level of uncertainty. Conclusion: The level of uncertainty in people living with HIV is high. It is necessary to carry out comprehensive interventions that favour the reduction of the level of uncertainty and thus improve the well-being and quality of life of people living with HIV.
导言:在世界范围内,人类免疫缺陷病毒(HIV)感染仍然是一个新出现的公共卫生问题。如果对这种慢性退行性疾病进行阳性筛查,病毒就会在人的身体、心理、社会和精神上产生变化,从而在面对不确定的未来时产生不确定性。识别患者的不确定性,使护理专业人员能够计划整体干预措施,以减少这一过程,并将健康与他们的慢性疾病经验结合起来,从而提高生活质量。目的:确定一组HIV感染者的不确定性水平。方法:定量、描述性、横向研究。对30名艾滋病毒感染者的非概率抽样,来自CONVIHVE莫雷利亚公民协会,Michoacán。采用Merle Mishel的“疾病前不确定性”(MUIS)量表和识别卡,信度为(.904)。采用SPSS V统计软件对数据进行分析。22. 结果:男性占总人口的83.3%,女性占16.7%,32-39岁占36.6%,其中男性占70%。单身人群中,53.3%的人拥有学士学位。60%的人有工作。30%的人是指确诊10年以上,治疗时间少于5年的53.3%。76.7%是天主教徒。在所有参与者中,23.3%的人表现出低水平的不确定性,其次是26.7%的人表现出常规水平的不确定性,50%的人表现出高水平的不确定性。结论:HIV感染者的不确定性水平较高。有必要开展有利于减少不确定程度的综合干预措施,从而改善艾滋病毒感染者的福祉和生活质量。
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引用次数: 0
Kinetics of morphofunctional changes in the center of inflammation of pulmonary tissue caused by staphylococcus aureus 金黄色葡萄球菌引起的肺组织炎症中心形态功能改变动力学
Pub Date : 2018-05-18 DOI: 10.15406/IPMRJ.2018.03.00103
S. Ga, Rakhmatullaev Hu, Zalyalova Zs
In three experimental series of experimental animals caused by inflammation model with a standard strain of Staphylococcus aureus. (Strain WOOD -46). Held control of the morphological and functional changes in the lung tissue at different times from the beginning of the introduction of Staphylococcus aureus. The histological method was used. The observations indicate a dose-dependent morphological changes in the lung tissue with inflammation caused by various doses of the standard Staphylococcus aureus.
在三个实验系列中,实验动物用标准菌株金黄色葡萄球菌引起的炎症模型。(Strain WOOD -46)。从引入金黄色葡萄球菌开始,控制不同时间肺组织的形态和功能变化。采用组织学方法。观察结果表明,不同剂量的标准金黄色葡萄球菌引起的肺组织炎症的剂量依赖性形态学变化。
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引用次数: 0
Public health equity in information asymmetry – phenomenological studies upon SARS-CoV-2 supervirus mutation 信息不对称中的公共卫生公平——SARS-CoV-2超病毒变异的现象学研究
Pub Date : 1900-01-01 DOI: 10.15406/ipmrj.2023.08.00326
Yang I. Pachankis
In the context of SARS-CoV-2 crises, the phenomenological studies analyze the market phenomenon of People’s Republic of China (PRC) in public health. With PRC’s diplomatic behaviors around the national, international, and global public health crises, the phenomenological occurrence was further questioned into on accounts of genetic engineering, PRC’s top-down behaviors, and financial and non-financial incentives in public health inequality with its declared universal healthcare coverage. The phenomenological studies further the evidence chains on the PRC governmental bodies’ purposeful and intentional crimes against humanity, with the public health system they designed to hide criminal evidences in the clinical evidence chains. Albeit it is paramount for the medical professionals to prepare for a certain but unforeseeable surge of biomedical intrusion, the phenomenological studies call for military interventions on the humanitarian catastrophe that have twice in three years caused unnecessary sufferings regionally and globally. Without it, the world can only wait to detect Chinese passengers’ carriers instead of obtaining firsthand data, potentially leading to more deaths and mutation risks. Only peace-building and government reformation on democratic basis in the region can solve the humanitarian crisis once and for all. No scientific evidence establish the virological homogeneity between SARS-CoV and MERS-CoV, and the politicization of the HIV-1 homogeneous virus underlies the 2002 - 2003 outbreak that caught international attention. The long-term PRC derogation on the global institutional determinants of health has led to the global mandates of poisoning by “vaccination”. The viral RNA origin is inferred to mutational result of PRC’s nuclear weapon tests.
在SARS-CoV-2危机背景下,现象学研究分析了中华人民共和国公共卫生市场现象。随着中华人民共和国围绕国家、国际和全球公共卫生危机的外交行为,这种现象的发生被进一步质疑为基因工程、中华人民共和国自上而下的行为以及其宣布的全民医疗覆盖下公共卫生不平等的财政和非财政激励。现象学进一步研究了中国政府机关故意和故意危害人类罪的证据链,他们设计的公共卫生系统将犯罪证据隐藏在临床证据链中。尽管医务专业人员为某种不可预见的生物医学入侵的激增做好准备是至关重要的,但现象学研究呼吁对人道主义灾难进行军事干预,这种灾难在三年内两次在区域和全球造成不必要的痛苦。如果没有它,世界只能等待发现中国乘客的携带者,而不是获得第一手数据,这可能导致更多的死亡和突变风险。只有在该地区建立和平和民主基础上进行政府改革,才能一劳永逸地解决人道主义危机。没有科学证据证明SARS-CoV和MERS-CoV之间的病毒学同质性,而HIV-1同质病毒的政治化是2002 - 2003年引起国际关注的疫情的基础。长期以来,中国对全球健康制度决定因素的减损导致了“疫苗接种”中毒的全球授权。病毒RNA的起源被推断为中国核武器试验的突变结果。
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引用次数: 0
Biocomposites composed of cartilage and natural rubber latex 由软骨和天然胶乳组成的生物复合材料
Pub Date : 1900-01-01 DOI: 10.15406/ipmrj.2023.08.00331
Y. Okamoto, M. Okamoto
We have successfully fabricated the cartilage/natural rubber latex (NRL) biocomposites via human mesenchymal stem cells (hMSCs) spheroid under hypoxic condition. It was revealed that NRL nanoparticles acted as the main component, providing surface heterogeneity for the spheroids and resulting in a mechanically stable structure with a modulus two times higher compared to controls. The formation of the cartilage/NRL nanoparticles biocomposite results in having a stiff property was demonstrated. The gene expression levels of SRY-box 9 (SOX9), aggrecan and type II collagen (Col-II), and formation of glycosaminoglycan’s were higher in spheroids under hypoxic conditions, and administration of NRL nanoparticles enhanced chondrogenic differentiation is successfully induced. The promise of NRL nanoparticles for well-controlled chondrogenic differentiation and mechanically stable cartilage tissue was demonstrated.
在缺氧条件下,利用人间充质干细胞(hMSCs)制备软骨/天然胶乳(NRL)生物复合材料。结果表明,NRL纳米颗粒作为主要成分,为球体提供了表面非均匀性,并产生了机械稳定的结构,其模量比对照组高两倍。软骨/NRL纳米颗粒生物复合材料的形成导致具有刚性特性。在低氧条件下,球状体中SRY-box 9 (SOX9)、聚集蛋白和II型胶原蛋白(Col-II)的基因表达水平和糖胺聚糖的形成水平较高,并且NRL纳米颗粒增强了软骨分化。NRL纳米颗粒有望用于控制良好的软骨分化和机械稳定的软骨组织。
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引用次数: 1
Sarcopenia and hip osteoarthritis: possible role for targeted electrical and biophysical muscle stimulation applications 肌肉减少症和髋关节骨关节炎:有针对性的电和生物物理肌肉刺激应用的可能作用
Pub Date : 1900-01-01 DOI: 10.15406/ipmrj.2023.08.00338
R. Marks
Background: Hip osteoarthritis- a painful oftentimes longstanding progressively disabling condition that occurs predominantly among sizeable numbers of older adults may be detrimentally impacted by an atrophic muscle condition known as sarcopenia. Aim: This mini review examines the possible utility of electrical or magnetic muscle stimulation for mitigating sarcopenic muscle mass declines that may be age or disease associated or both among older adults diagnosed as having early or late stage hip osteoarthritis. Methods: Peer reviewed literature on hip osteoarthritis discussing sarcopenia, as well as any evidence that electrical or magnetic muscle stimulation as applied to foster muscle mass increments are relevant to ameliorating this condition were sought and examined. Results: Many reports show hip osteoarthritis remains a highly debilitating disease to counteract and is a condition where the surrounding muscles may be atrophic. While most point to exercise and nutrition as suitable muscle interventions for countering sarcopenia, a favorable role for electrical stimulation cannot be ruled out. Conclusions: There is a possible missed opportunity that implies muscle preservation at the hip through electrical stimulation will be beneficial for fostering function at all stages of hip joint osteoarthritis progression, even if surgery is forthcoming, and should be studied further.
背景:髋关节骨性关节炎是一种痛苦的长期进行性致残疾病,主要发生在相当数量的老年人中,可能会受到肌肉萎缩的不利影响,称为肌肉减少症。目的:这篇小型综述探讨了电或磁肌肉刺激对减轻老年诊断为早期或晚期髋关节骨关节炎的老年人中可能与年龄或疾病相关或两者兼而有之的肌肉减少性肌肉质量下降的可能效用。方法:同行评议的髋关节骨性关节炎文献讨论肌肉减少症,以及任何证据表明,电或磁肌肉刺激,用于促进肌肉质量的增加,是有关改善这种情况的寻求和检查。结果:许多报告显示,髋骨关节炎仍然是一种高度衰弱的疾病,需要对抗,是一种周围肌肉可能萎缩的情况。虽然大多数人指出运动和营养是对抗肌肉减少症的合适肌肉干预措施,但不能排除电刺激的有利作用。结论:这可能是一个错失的机会,意味着通过电刺激在髋关节骨关节炎进展的各个阶段保留肌肉对促进功能是有益的,即使即将进行手术,也应该进一步研究。
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引用次数: 0
Thalidomide-induced sensory axonal polyneuropathy: A case report 沙利度胺致感觉轴索多神经病变1例
Pub Date : 1900-01-01 DOI: 10.15406/ipmrj.2023.08.00341
David Eliécer Rodríguez, Fernando Ortiz, Jefferson Alexander Caleño, Mauro Andres Herrera
Introduction: Several chemotherapeutic agents are currently available for the management of various malignancies; however, many are associated with adverse effects. A case of thalidomide- induced polyneuropathy is described below. Case Description: A 65year old man, with a history of secondary myelofibrosis in management with thalidomide, consulted for 5months of neuropathic pain and paresthesia in both hands. On physical examination, he presented hypoesthesia and hyperalgesia in both hands. In the electrodiagnostic studies (EDX) a sensory polyneuropathy of axonal type was concluded. Discussion: Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect that occurs in up to 70% of patients. Symptomatology includes motor and sensitive deficit. EDX studies confirm diagnoses and characteristics. For the particular case of thalidomide involvement is mainly axonal. There is no standard treatment for CIPN, but several drugs can improve symptoms. Conclusions: CIPN is a frequent complication in patients managed with chemotherapy. The physiatrist is the ideal professional to provide a comprehensive approach to this entity, in order to improve the patient’s functionality.
介绍:目前有几种化疗药物可用于各种恶性肿瘤的治疗;然而,许多药物都有副作用。下面描述一例沙利度胺引起的多发性神经病变。病例描述:65岁男性,有继发性骨髓纤维化史,使用沙利度胺治疗,因神经性疼痛和双手感觉异常就诊5个月。体格检查时,他表现为双手感觉减退和痛觉过敏。电诊断结果显示为轴突型感觉多发性神经病。讨论:化疗引起的周围神经病变(CIPN)是发生在高达70%的患者中的副作用。症状包括运动和敏感缺陷。EDX研究证实了诊断和特征。在特殊情况下,沙利度胺主要累及轴突。CIPN没有标准的治疗方法,但有几种药物可以改善症状。结论:CIPN是化疗患者的常见并发症。为了改善病人的功能,理疗师是理想的专业人士,为这个实体提供全面的方法。
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引用次数: 0
Dysthanasia and palliative care: nursing in palliative care 失调与姑息治疗:姑息治疗中的护理
Pub Date : 1900-01-01 DOI: 10.15406/ipmrj.2023.08.00339
Juliana Felipelli Bernardes
According to the World Federation of Right to Die Societies the term Comfort Care is often used as a synonym for Palliative Care. Palliative Care encompasses in its concept the management of pain and symptoms, support for the patient and family, and the opportunity to achieve a meaningful closure to life. Thus, the article delves into various texts to understand the role of the nursing professional in the maintenance and promotion of health in view of palliative care. Thus, the guiding question of this article is: in the national scientific scenario, how is palliative care presented in the nursing field? The bibliographic review, as a data collection technique, was selected, aligning itself with the expectations of this work, which is to present a broad discussion on the theme in question. This work was carried out from a search on the Google Academic platform, which presented the bases PubMed, Virtual Health Library (VHL) and Portal Capes. The descriptors used were “Palliative care”, “dysthanasia” and “nursing care”, applying a time cut from 2015 to 2023, being selected 30 articles with titles associated with the terms “nursing and complications associated with palliative care”. From the analysis of the articles, it was noted that the professional nurse, in palliative care, must be qualified to make accurate assessments, lead, plan, and have the human eye when practicing care. These assessments result in the nurse’s ability to develop plans for dealing with symptoms and side effects: constipation from narcotic analgesics, nausea and vomiting, lethargy, insomnia, anxiety, and dyspnea. The nurse and the multidisciplinary team responsible for implementing techniques to minimize these problems that are painful for patients and family members who are present in the face of their loved one’s suffering.
根据世界死亡权利协会联合会的说法,“舒适护理”一词经常被用作姑息治疗的同义词。姑息治疗的概念包括对疼痛和症状的管理,对病人和家属的支持,以及实现有意义的生命结束的机会。因此,本文深入研究了各种文本,以了解护理专业人员在姑息治疗中维护和促进健康的作用。因此,本文的指导问题是:在国家科学情景下,姑息治疗在护理领域是如何呈现的?选择书目审查作为一种数据收集技术,使其与这项工作的期望保持一致,这是为了就有关主题进行广泛的讨论。这项工作是在谷歌学术平台上进行的搜索,该平台提供了PubMed、虚拟健康图书馆(VHL)和Portal Capes等基地。使用的描述词是“姑息治疗”、“精神失调”和“护理”,时间从2015年缩短到2023年,选择了30篇标题与“姑息治疗相关的护理和并发症”相关的文章。通过对相关文章的分析,指出姑息治疗专业护士在实施护理时必须具备准确评估、领导、计划和人眼的能力。这些评估使护士能够制定计划来处理症状和副作用:麻醉镇痛药引起的便秘、恶心和呕吐、嗜睡、失眠、焦虑和呼吸困难。护士和多学科团队负责实施技术,以尽量减少这些问题,使患者和家属在面对他们所爱的人的痛苦时感到痛苦。
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引用次数: 0
Rehabilitation of a rare presentation of tuberculous meningoencephalitis: a case report 一例罕见结核性脑膜脑炎的康复治疗报告
Pub Date : 1900-01-01 DOI: 10.15406/ipmrj.2023.08.00334
Xénia Verraest, Filipe Ermida, A. Paiva, Raquel Nunesv, Francisco Repas, Sandra Oliveira, F. Carvalho
Tuberculous Meningoencephalitis (TBM) is an infectious disease of the central nervous system caused by Mycobacterium tuberculosis. It mainly involves the meninges and brain parenchyma, as well as the spinal cord and meninges. The spectrum of complications of TBM includes hydrocephalus, tuberculoma formation and stroke. Stroke secondary to TBM can cause irreversible brain damage and lead to poor clinical outcomes. TBM diagnosis is challenging due to atypical early symptoms and delayed laboratory examination. Therefore, early identification, diagnosis and treatment are often difficult. Rehabilitation is one of the key components in managing TBM and is expected to enhance recovery and prevent disabilities.
结核性脑膜脑炎(TBM)是一种由结核分枝杆菌引起的中枢神经系统传染病。它主要累及脑膜和脑实质,以及脊髓和脑膜。TBM的并发症包括脑积水、结核瘤形成和中风。TBM继发脑卒中可造成不可逆的脑损伤,并导致不良的临床结果。由于不典型的早期症状和延迟的实验室检查,TBM诊断具有挑战性。因此,早期识别、诊断和治疗往往很困难。康复是管理TBM的关键组成部分之一,有望加强康复和预防残疾。
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引用次数: 0
Abdominal pain in an elderly with a twist: a case of colonic volvulus 老年扭转腹痛1例:结肠扭转1例
Pub Date : 1900-01-01 DOI: 10.15406/ipmrj.2022.07.00309
Sofia Moura de Azevedo, F. Gonçalves
Abdominal pain in the elderly patient is a common symptom and reason to resort to the emergency service. Geriatric ill patients present unique challenges in the anamnesis, physical examination and to determine expectations for rehabilitation and meaningful recovery. We present the case of an 80-year-old man, dependent on activities of daily living due to dementia. He was admitted to the emergency department with a clinic of abdominal pain and constipation. Abdominal radiography revealed dilatation of the sigmoid colon (coffee bean sign), as did abdominal CT, suggesting the diagnosis of intestinal volvulus. He underwent decompression colonoscopy with resolution. There was no evidence of neoplasia on abdominal CT or endoscopic study, or of another obstructive cause. Sigmoid volvulus is common in men over 70 years, with neuropsychiatric pathology and as a risk factor the patient had immobility and a long and redundant colon described in the endoscopic examination. This is a pathology with high mortality and risk of recurrence to be recognised in institutionalized elderly people.
腹部疼痛在老年患者是一个常见的症状和原因诉诸于急诊服务。老年病患者在记忆、体格检查和确定康复期望和有意义的恢复方面面临着独特的挑战。我们提出的情况下,80岁的男子,依赖于日常生活活动,由于痴呆。他因腹痛和便秘被送进急诊科。腹部x线摄影显示乙状结肠扩张(咖啡豆征),腹部CT显示,提示肠扭转诊断。他接受减压结肠镜检查。腹部CT或内窥镜检查均未发现瘤变或其他梗阻性病因。乙状结肠扭转常见于70岁以上的男性,伴有神经精神病理,作为一个危险因素,患者在内窥镜检查中表现为行动不动和长而多余的结肠。这是一种高死亡率和复发风险的病理,需要在机构老年人中认识到。
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引用次数: 0
期刊
International Physical Medicine &amp; Rehabilitation Journal
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