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Experience of Surgical Treatment of Complex Forms of Ebstein’s Anomaly through the Method of Hemodynamic Correction 血液动力学矫正法治疗复杂型Ebstein畸形的经验
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/dt031-2533
I. Dziuryi, I. Truba, Oleksandr S. Golovenko, I. Perepeka, V. Lazoryshynets
Ebstein’s anomaly (EA) is a rare and complex congenital heart disease, with a prevalence of 4 to 7 cases per 100,000 live births. At this stage of the development of EA surgery, significant progress has been made in our understanding and treatment of EA, but the question of the tactics of treating complex forms, especially in the period of infancy and early childhood, remains open. Due to significant phenotypic heterogeneity, the treatment of EA varies greatly from patient to patient and depends on many factors that require a comprehensive approach. The choice of the method of surgical correction directly depends on the anatomical features: the degree of dysplasia, rotation and displacement of the tricuspid valve, the degree of atrialization of the right ventricle, the combination with other congenital heart diseases, and the severity of hemodynamic disorders. The aim. To evaluate perioperative characteristics in patients with complex forms of EA, immediate and long-term results after hemodynamic correction. Materials and methods. In the period from 1996 to 2022, at the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine, one and a half ventricle repair was performed in 18 patients with complex forms of EA. There were 12 (67%) male patients, 6 (33%) female patients. The median age of the patients at the time of surgery was 30 months [3.5; 312]. The main diagnostic method in determining the defect and assessing the immediate and remote results was echocardiography and probing of the heart cavities. In order to qualitatively evaluate the perioperative, immediate and long-term results to determine the optimal tactics and terms of surgical intervention, prevention of possible complications, all the patients were divided into two age groups: I group up to 2.5 years including 9 patients (50%), II group older than 2.5 years including 9 patients (50%). Results. In the postoperative period, 2 (11%) deaths were noted in both groups. In all the deceased patients, the cause of death was acute heart failure and acute respiratory failure. The analysis of the postoperative period showed normal results in such a cohort of highly complex patients of both groups, but a more stable course was noted among patients of the I group, as indicated by statistically significant values for the duration of mechanical ventilation, stay in the intensive care unit, stay in the hospital, the average dose of sympathomimetic support and its duration, the total duration of exudation in the comparison groups. An uncomplicated course of the early postoperative period was observed in 8 (44%) patients. The remaining 10 (56%) patients of both groups had: I group, 3 (33%) patients: 7 complications; II group, 5 (55%) patients: 13 complications. In 5 patients (2 patients in I group and 3 patients in II group), attention-grabbing acute heart failure was observed, which required high doses and long-term sympathomimetic support, and i
埃布斯坦异常(EA)是一种罕见而复杂的先天性心脏病,每100000名活产婴儿中有4至7例患病。在EA手术发展的这个阶段,我们对EA的理解和治疗已经取得了重大进展,但治疗复杂形式的策略问题,特别是在婴儿期和儿童早期,仍然悬而未决。由于显著的表型异质性,EA的治疗因患者而异,取决于许多需要综合治疗的因素。手术矫正方法的选择直接取决于解剖特征:发育不良程度、三尖瓣旋转移位程度、右心室心房化程度、与其他先天性心脏病的合并程度以及血液动力学障碍的严重程度。目标。评估复杂形式EA患者的围手术期特征,血液动力学校正后的即时和长期结果。材料和方法。1996年至2022年期间,在乌克兰国家医学科学院国家阿莫索夫心血管外科研究所,对18名患有复杂形式EA的患者进行了一个半心室修复。其中男性患者12例(67%),女性患者6例(33%)。手术时患者的中位年龄为30个月[3.5;312]。确定缺陷和评估即时和远程结果的主要诊断方法是超声心动图和心腔探查。为了定性评估围手术期、近期和长期结果,以确定手术干预的最佳策略和条件,预防可能的并发症,所有患者被分为两个年龄组:2.5岁以下的I组,包括9名患者(50%),2.5岁以上的II组,包括九名患者(50%)。后果术后两组均有2例(11%)死亡。在所有死亡患者中,死亡原因为急性心力衰竭和急性呼吸衰竭。对术后时期的分析显示,在这两组高度复杂的患者队列中,结果正常,但I组患者的病程更稳定,如机械通气持续时间、重症监护室住院时间、拟交感神经支持的平均剂量及其持续时间的统计学显著值所示,比较组渗出的总持续时间。在8例(44%)患者中观察到术后早期的无并发症过程。两组其余10例(56%)患者均有:Ⅰ组3例(33%),并发症7例;Ⅱ组5例(55%),并发症13例。在5名患者中(I组2名,II组3名),观察到引人注目的急性心力衰竭,需要高剂量和长期拟交感神经支持,2名患者导致死亡。平均观察期为45个月[6;190]。在观察期内,两组的13名(72%)患者均未观察到死亡,3名(17%)患者失去了联系。右心室功能没有受损,但只有8名(44%)患者左心室收缩功能恢复。5例(28%)患者的三尖瓣功能不全为轻度,6例(33%)为中度,2例(11%)为重度。结论。对于不同年龄的患者,尤其是新生儿和婴儿,由于左心室的明显扩张和收缩功能障碍,以及由于左心室几何形状的变化导致的系统输出量的急剧下降,确定复杂形式的EA的治疗策略是一个严重的问题。半心室矫正技术显示出非常有希望的结果,可能成为严重EA和明显右心室功能不全患者的首选技术。
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引用次数: 0
Surgical Emphysema without Pneumothorax: A Diagnostic Dilemma 非胸腔积液的外科治疗:诊断难题
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/kss012-8588
Dinesh Kumar Sathanantham, Spurthi Sanganbhonia, C. Shashirekha, P. Sreeramulu
Surgical emphysema, also widely known as subcutaneous emphysema, is defined as a clinical state in which air gets trapped subcutaneously. The etiology may be traumatic or atraumatic, and multiple causes in each are present. Case report. A 63-year-old female patient presented to the emergency room with a facial soft tissue injury following road traffic accident and developed surgical emphysema later on with no evidence of rib fractures or pneumothorax. Infectious etiology was ruled out. Due to the respiratory embarrassment, the patient was electively intubated. Conservative management was provided. Emphysema resolved within 24 hours after the accident. Discussion. Various theories have been outlined in literature, like Mackler effect, Crampton theory and ballvalve mechanism. In our case, it was difficult to apply any of these theories to confirm the diagnosis. Conservative management is still used in the treatment of surgical emphysema. Conclusion. Surgical emphysema is a common encounter in trauma practice, and its identification is essential to rule out any emergency causes which may lead to respiratory distress.
外科肺气肿,也被广泛称为皮下肺气肿,被定义为一种临床状态,其中空气被困在皮下。病因可能是创伤性或非创伤性的,每种病因都有多种原因。病例报告。一名63岁女性患者在道路交通事故后出现面部软组织损伤,随后出现手术肺气肿,没有肋骨骨折或气胸的证据。排除了感染性病因。由于呼吸窘迫,病人被选择性插管。提供保守管理。事故发生后24小时内肺气肿就消失了。讨论。文献中概述了各种理论,如麦克勒效应、克兰普顿理论和球阀机理。在我们的病例中,很难应用这些理论来确认诊断。手术肺气肿仍采用保守治疗。结论。外科肺气肿是创伤实践中常见的,其识别对于排除任何可能导致呼吸窘迫的紧急原因至关重要。
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引用次数: 0
Extended Reality Applications in Cardiac Surgery and Interventional Cardiology 扩展现实在心脏外科和介入心脏病学中的应用
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/pp018-5057
V. F. Petrov, M. Pankiv
Extended reality combines the real and digital worlds. This technology has found applications in all fields of medicine, including cardiac surgery and interventional cardiology. The paper describes the application of three types of extended reality, namely virtual, augmented and mixed realities. The aim. To explain the principles of operation of various types of extended reality using non-medical and medical applications as examples; to analyze the data from specialized publications in the field of cardiac interventions. Materials. Articles from the Pubmed database. Results. The article highlights important details of the heart and blood vessels image creation technique with which users operate. Primary data is obtained from imaging modalities like tomography or ultrasound, then it is segmented and processed for the virtual viewing. In virtual reality, three-dimensional (3D) images of the heart defects are analyzed in depth, and virtual manipulations can be performed that simulate the course of the operation. Virtual reality includes printing the heart on a 3D printer with subsequent executions on physical models, both diagnostic dissections and therapeutic surgical or endovascular simulations. In augmented reality, the created image of the internal anatomy of the defect is present near the surgeon, without interfering medical manipulations. In mixed reality, a virtual image is superimposed on the patient’s body, creating a detailed navigation map. Conclusions. Extended reality application deepens the understanding of anatomy due to stereoscopic visualization of the structure of the heart and blood vessels. Creating a model of a patient’s heart defect and simulating an operation on it shortens the “learning curve”, improves the professional skills of surgeons and cardiologists, and also allows for surgical and endovascular interventions individualization. Planning interventions in cardiac surgery and interventional cardiology with extended reality technologies influences decision-making and reduces the duration of operations.
扩展现实结合了现实世界和数字世界。这项技术已被应用于所有医学领域,包括心脏外科和介入心脏病学。本文介绍了虚拟现实、增强现实和混合现实这三种扩展现实的应用。的目标。以非医疗和医疗应用为例,解释各类扩展现实的运作原理;目的:分析来自心脏介入领域的专业出版物的数据。材料。Pubmed数据库中的文章。结果。本文重点介绍了用户操作的心脏和血管图像创建技术的重要细节。原始数据从成像方式如断层扫描或超声波中获得,然后对其进行分割和处理,用于虚拟观看。在虚拟现实中,对心脏缺陷的三维图像进行深入分析,并可以进行虚拟操作来模拟手术过程。虚拟现实包括在3D打印机上打印心脏,随后在物理模型上执行,包括诊断性解剖和治疗性手术或血管内模拟。在增强现实技术中,所创建的缺损内部解剖图像出现在外科医生附近,而不干扰医疗操作。在混合现实中,一个虚拟图像被叠加在病人的身体上,创建一个详细的导航地图。结论。由于心脏和血管结构的立体可视化,扩展现实应用加深了对解剖学的理解。创建一个病人心脏缺陷的模型,并在其上模拟手术,缩短了“学习曲线”,提高了外科医生和心脏病专家的专业技能,也允许手术和血管内干预的个体化。心脏外科和介入心脏病学的计划干预与扩展现实技术影响决策并缩短手术持续时间。
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引用次数: 0
Laparoscopic Treatment of Morgagni-Larrey Diaphragmatic Hernia with Reposition of the Transverse Colon in Patients with Cardiac Comorbidity. Clinical Observation 腹腔镜治疗心脏合并症患者的Morgagni-Larrey膈疝并横结肠复位。临床观察
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/ut015-6872
O. Usenko, O. S. Tyvonchuk, R. Vynogradov, D. Zhytnik
Morgagni-Larrey hernia is a rare form of diaphragmatic hernia (2-5% of cases) usually diagnosed in children; in adults, it is often detected in emergency cases or accidentally, during examinations or during surgery. The symptoms of the disease are non-specific, so the diagnosis is made using imaging methods (computed tomography is the gold standard). Currently, there is no single method of treating Morgagni-Larrey hernias. Closure of the defect is performed with or without the use of various mesh prostheses through the abdominal or thoracic route; open or minimally invasive access. The aim. To conduct a retrospective analysis of the treatment of adult patients with a Morgagni-Larrey diaphragmatic hernia, including those with cardiovascular comorbidity, with a comparison of symptoms, contents of the hernial sac, with the use of laparoscopic techniques and composite mesh prostheses. Materials and methods. The results of the treatment of three patients with a Morgagni-Larrey hernia in the period from 2020 to 2022 at the Shalimov National Institute of Surgery and Transplantation are shown. In two patients, the content of the hernial sac was a loop of the transverse colon, in one, the content of the hernial sac was a greater omentum. Taking into account the accompanying cardiovascular pathology, an interdisciplinary council consisting of a surgeon, anesthesiologist, and cardiologist recommended laparoscopic surgical intervention. Laparoscopic allogeneoplasty with composite prosthesis implantation was performed in three patients. Conclusions. The laparoscopic method of treating diaphragmatic hernias is safe and effective. The use of composite prostheses in combination with tension closure of the defect allows to reduce the risk of recurrence of the disease in the distant postoperative period.
Morgagni-Larrey疝是一种罕见的膈疝(2-5%的病例),通常在儿童中诊断;在成人中,通常在紧急情况下或在检查或手术期间意外发现。这种疾病的症状是非特异性的,因此诊断是使用成像方法(计算机断层扫描是金标准)。目前,治疗Morgagni-Larrey疝没有单一的方法。通过腹路或胸路使用或不使用各种网状假体来闭合缺损;开放或微创手术。的目标。回顾性分析成年Morgagni-Larrey膈疝(包括心血管合并症)患者的治疗,并比较症状、疝囊内容物、腹腔镜技术和复合网状假体的使用。材料和方法。图为2020年至2022年期间在沙利莫夫国家外科和移植研究所治疗的三名Morgagni-Larrey疝患者的结果。2例疝囊内容物为横结肠环,1例疝囊内容物为大网膜。考虑到伴随的心血管病理,一个由外科医生、麻醉师和心脏病专家组成的跨学科委员会建议进行腹腔镜手术干预。腹腔镜同种异体成形术联合复合假体植入术治疗3例。结论。腹腔镜下治疗膈疝安全有效。复合假体结合张力闭合缺损可降低术后后期疾病复发的风险。
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引用次数: 0
A Clinical Case of Surgical Treatment of a Patient with Two Postinfarction Left Ventricular Aneurysms 一例梗死后两例左室动脉瘤的外科治疗
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/gr026-7884
O. Gogayeva, S. A. Rudenko, O. Nudchenko, S. V. Fedkiv
Postinfarction left ventricular (LV) aneurysm develops as a result of untimely restoration of blood flow in the infarct-dependent artery and is associated with an increase in cardiac mortality. The presence of several postinfarction LV aneurysms of different localizations in one patient is a rare and casuistic case. Case description. Patient B., 53 years old, was urgently hospitalized in the National Amosov Institute with complaints of shortness of breath, pain behind the sternum with radiation to the left arm, occurring with minimal physical exertion. Electrocardiography showed scar changes in the anterior-apical-lateral area of the LV with a thrombosed aneurysm of the LV lateral wall. Echocardiography revealed a severe decrease in the global contractility of the LV with ejection fraction of 24% and aneurysms of the septal-apical and posterior-lateral segments of LV. Pericarditis was found, with a layer of fluid of 1.7 cm on the LV posterior wall and 2.0 cm on the LV apex. Emergency coronary angiography revealed an occlusion of the middle third of the left anterior descending artery and the middle third of the left circumflex coronary artery, 50-70% stenosis of the right coronary artery and confirmed widespread LV aneurysm. Cardiac magnetic resonance imaging with intravenous contrast confirmed the change in configuration and significant dilatation of the LV due to the formation of two LV aneurysms with mural thrombus in the cavity of the posterior-lateral LV aneurysm. After discussing the patient’s data, the cardiac team performed emergency on-pump coronary bypass surgery, resection of the LV aneurysm with thrombectomy. The operation took 5 hours, aorta cross-clamp time was 75 min, perfusion time was 117 min, intraoperative blood loss was 300 ml. The patient was extubated in 2 hours after the end of the operation, the length of intensive care unit stay was 2 days. On the 9th day after the operation, the patient was discharged from the Institute with positive clinical, electrocardiographic and echocardiographic (LV ejection fraction 38%) dynamics. Conclusions. This clinical case demonstrates successful surgical treatment of two LV aneurysms, a rare complication of acute myocardial infarction. Preoperative detailed diagnosis and discussion of the patient’s data by the heart team, selection of the optimal term and volume of the operation allowed to quickly stabilize the patient’s condition and achieve a positive immediate result.
梗死后左心室(LV)动脉瘤是梗死依赖性动脉血流恢复不及时的结果,与心脏死亡率的增加有关。一名患者出现多个不同位置的梗死后左心室动脉瘤是一种罕见且偶然的病例。案例描述。患者B,53岁,在国家阿莫索夫研究所紧急住院,主诉呼吸急促,胸骨后疼痛,左臂受到辐射,体力消耗很小。心电图显示左心室前心尖外侧区有瘢痕改变,左心室侧壁有血栓性动脉瘤。超声心动图显示左心室整体收缩力严重下降,射血分数为24%,左心室间隔顶端和后外侧段有动脉瘤。发现心包炎,左心室后壁有1.7厘米的液体层,左心室顶端有2.0厘米的液体。急诊冠状动脉造影显示左前降支中三分之一和左旋冠状动脉中三分之二闭塞,右冠状动脉狭窄50-70%,证实广泛存在左心室动脉瘤。静脉造影的心脏磁共振成像证实,由于左心室后外侧动脉瘤腔内形成两个附壁血栓的左心室动脉瘤,左心室结构发生变化,并出现显著扩张。在讨论了患者的数据后,心脏团队进行了紧急泵送冠状动脉搭桥手术,切除左心室动脉瘤并切除血栓。手术耗时5小时,主动脉阻断时间75分钟,灌注时间117分钟,术中失血300毫升。患者在手术结束后2小时内拔管,重症监护室住院时间为2天。术后第9天,患者出院,临床、心电图和超声心动图(左心室射血分数38%)动力学呈阳性。结论。这一临床病例证明了两个左心室动脉瘤的手术治疗是成功的,这是急性心肌梗死的一种罕见并发症。术前心脏团队对患者的数据进行详细诊断和讨论,选择最佳的手术期限和手术量,可以快速稳定患者的病情,并立即取得积极的效果。
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引用次数: 0
A Case of an Unusual Clinical Course of Mitral Stenosis 二尖瓣狭窄异常临床病程1例
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/vi017-7377
R. M. Vitovskyi, V. Isaienko, A. R. Vitovskyi, O. V. Satmari, Inna G. Yakovenko, N. Volkova
Background. The stage 4 mitral stenosis is accompanied by atrial fibrillation which significantly worsens the prognosis due to the possibility of thromboembolic complications. However, sinus rhythm does not exclude the possibility of thrombosis which sometimes requires differential diagnosis with heart tumors. The aim. To present a case of unusual thrombus formation in a patient with significant mitral stenosis on the background of sinus rhythm and describe the specifics of determining indications for surgical intervention. Case report. Female patient K., 42 years old, who was admitted on January 12, 2023 to the National Amosov Institute of Cardiovascular Surgery, had been suffering from rheumatism for the past 20 years. In this case, the clinical course of mitral stenosis could be classified as stage 4, since there were signs of severe heart failure (shortness of breath on light exertion, peripheral edema, right-sided pleuritis, pulmonary thrombosis). However, the patient had sinus rhythm, which is more characteristic of the stage 3 mitral stenosis. The patient underwent mitral valve prosthetic surgery and removal of an unusual thrombus from the pulmonary valve cavity on January 23, 2023. Conclusions. The course of mitral stenosis, despite its thorough study, may have unusual clinical and instrumental manifestations, which requires differential diagnosis with heart tumors and other diseases. In some cases, the mechanism of thrombus formation can be extremely unusual, which can be a subject for discussion by cardiologists.
背景。第4期二尖瓣狭窄伴有心房颤动,由于血栓栓塞并发症的可能性,预后明显恶化。然而,窦性心律不排除血栓形成的可能性,有时需要与心脏肿瘤鉴别诊断。的目标。提出一例在窦性心律背景下二尖瓣明显狭窄患者的不寻常血栓形成,并描述确定手术干预指征的具体情况。病例报告。患者K某,女,42岁,于2023年1月12日入住国立阿莫索夫心血管外科研究所,患风湿病已有20年。本例二尖瓣狭窄的临床过程可归类为4期,因为有严重心力衰竭的迹象(轻度运动时呼吸短促、周围水肿、右侧胸膜炎、肺血栓形成)。然而,患者有窦性心律,这更具有3期二尖瓣狭窄的特征。患者于2023年1月23日接受了二尖瓣修复手术,并从肺瓣腔中取出了一个不寻常的血栓。结论。二尖瓣狭窄的病程,尽管研究得很透彻,但可能有不寻常的临床和仪器表现,需要与心脏肿瘤和其他疾病鉴别诊断。在某些情况下,血栓形成的机制可能非常不寻常,这可能是心脏病专家讨论的主题。
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引用次数: 0
Prediction of the Development of Acute Heart Failure of High Grades in Patients with Myocardial Infarction and Percutaneous Coronary Intervention 经皮冠状动脉介入治疗并发高级别急性心力衰竭的预测
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/sr020-0915
A. Solomonchuk, L. Rasputina, D. Didenko
The aim of the study was to determine the risk factors for the occurrence of acute heart failure (AHF) of high degrees (Killip classes III and IV) among patients with myocardial infarction (MI). Materials and methods. We examined 308 MI patients who were treated at the specialized cardiology department. The mean age of the subjects was 62.9±0.6 years. There were 161 (52.3%) patients with MI without signs of heart failure (HF) (Killip class I), 44 (14.3%) with MI combined with class II AHF, 55 (17.8%) with MI and class III AHF, and 48 (15.6%) with MI and Killip class IV AHF. In addition to the general clinical examination, all the patients underwent additional laboratory examination (quantitative determination of troponin I, D-dimer, creatine kinase-MB, C-reactive protein, N-terminal prohormone of brain natriuretic peptide [NT-proBNP]), echocardiography and lung ultrasound during hospitalization, as well as coronary angiography. Results. A correlation between the occurrence of class III AHF (pulmonary edema) and class IV AHF (cardiogenic shock) and a number of anamnestic, clinical, functional and laboratory indicators was established. The following predictors of the development of class III AHF among patients with MI were calculated through regression analysis: a decrease in the level of O2 saturation during hospitalization, an increase in blood pressure during hospitalization, localization of the main heart attack-related lesion of the distal part of the right coronary artery, a decrease in the left ventricular ejection fraction. With less significance, predictors of the development of class III AHF were also defined as a decrease in the level of hemoglobin, the duration of hypertension in the history, the degree of hypertension, the history of any form of atrial fibrillation. Conclusions. A decrease in diastolic blood pressure irrespective of medical support and an increase in the level of NT-proBNP were established as predictors of the development of Killip class IV AHF. Further studies to predict the occurrence of HF and long-term consequences after MI with high-grade HF are promising and can provide an opportunity to optimize the treatment of patients by preventing severe complications.
该研究的目的是确定心肌梗死(MI)患者发生高度急性心力衰竭(AHF) (Killip III级和IV级)的危险因素。材料和方法。我们研究了308例在专业心内科治疗的心肌梗死患者。受试者平均年龄62.9±0.6岁。161例(52.3%)心肌梗死患者无心衰(HF) (Killip I级),44例(14.3%)心肌梗死合并II级AHF, 55例(17.8%)心肌梗死合并III级AHF, 48例(15.6%)心肌梗死合并Killip IV级AHF。除常规临床检查外,所有患者在住院期间均进行了额外的实验室检查(肌钙蛋白I、d -二聚体、肌酸激酶mb、c反应蛋白、脑利钠肽n端激素原[NT-proBNP]的定量测定)、超声心动图、肺超声以及冠状动脉造影。结果。建立了III级AHF(肺水肿)和IV级AHF(心源性休克)的发生与多项记忆、临床、功能和实验室指标之间的相关性。通过回归分析计算心肌梗死患者发生III级AHF的预测因素:住院期间血氧饱和度降低、住院期间血压升高、右冠状动脉远端主要心脏病相关病变定位、左心室射血分数降低。III类AHF发展的预测因子也被定义为血红蛋白水平的降低、史上高血压的持续时间、高血压程度、任何形式的心房颤动史。结论。不考虑医疗支持的舒张压降低和NT-proBNP水平升高被确定为Killip IV级AHF发展的预测因子。进一步研究预测心梗合并高级别心衰后HF的发生和长期后果是有希望的,并且可以通过预防严重并发症来优化患者的治疗。
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引用次数: 0
Surgical Reconstruction of Mitral-Tricuspid Insufficiency Combined with Biatriomegaly in Marfan Syndrome 马凡氏综合征二尖瓣-三尖瓣功能不全合并双心房肿大的手术重建
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/pb028-1624
V. Popov, O. Bolshak, V. Boukarim, Olena V. Khoroshkovata, O. M. Gurtovenko, Evgen V. Novikov
The aim. To analyze the results of introduction of complex reconstruction of the left and right parts of the heart in Marfan syndrome combined with mitral-tricuspid insufficiency, biatriomegaly and left ventriculomegaly. Materials and methods. As an example of this pathology, we present our observation. Female patient T., 24 years old, was examined and treated from 7/27/2022 to 8/17/2022 at the Department of Surgical Treatment of Acquired Heart Diseases of the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine with a diagnosis: Marfan syndrome. Stage IV mitral-tricuspid insufficiency. Biatriomegaly. High pulmonary hypertension. Permanent form of atrial fibrillation (for 10 years, since 2011). IIB heart failure with left ventriculomegaly with reduced left ventricular ejection fraction. NYHA functional class IV+. The patient underwent surgery in the following volume: mitral valve replacement with full preservation of the valve apparatus + tricuspid valve plasty with the imposition of a support ring + triangular plasty of the left atrium with its partial resection + resection of the right atrium. Results. Within 4 months after surgery, echocardiographic parameters showed significant decrease in the volume of the left ventricle, the diameters of both atria. In addition, there was a significant decrease in the level of N-terminal pro-brain natriuretic peptide and manifestations of heart failure. Conclusion. Taking into account the initial serious condition of the patient with Marfan syndrome and advanced mitral-tricuspid heart disease, left ventriculomegaly with a reduced left ventricular ejection fraction, biatriomegaly (left atrium 7.2 cm, right atrium 6.5 cm), permanent form of atrial fibrillation, complex reconstruction of the left and right parts of the heart leads to an improvement in the functional state of the myocardium.
的目标。目的分析马凡氏综合征合并二尖瓣-三尖瓣功能不全、双心房和左心室肿大的左、右心脏复杂重建的效果。材料和方法。作为这种病理的一个例子,我们提出我们的观察。女患者T., 24岁,于2022年7月27日至2022年8月17日在乌克兰国家医学科学院国家阿莫索夫心血管外科研究所获得性心脏病外科治疗科接受检查和治疗,诊断为马凡氏综合征。IV期二尖瓣-三尖瓣功能不全。Biatriomegaly。高肺动脉高压。永久性房颤(自2011年起持续10年)。IIB型心力衰竭伴左心室增大伴左心室射血分数降低。NYHA功能等级IV+。患者接受了以下手术:保留瓣器的二尖瓣置换术+施加支撑环的三尖瓣成形术+左心房三角形成形术并部分切除+右心房切除术。结果。术后4个月内超声心动图参数显示左心室容积、双心房直径明显减小。此外,n端前脑利钠肽水平显著降低,心衰表现明显。结论。考虑到马凡氏综合征和晚期二尖瓣-三尖瓣心脏病患者的初始严重病情,左心室增大,左心室射血分数降低,双心房增大(左心房7.2 cm,右心房6.5 cm),永久性房颤,心脏左右部分复杂的重建导致心肌功能状态的改善。
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引用次数: 0
Predictors of Pacing-Induced Cardiomyopathy in Patients with Permanent Right Ventricular Pacing and Preserved Left Ventricular Systolic Function 永久性右心室起搏和保留左心室收缩功能患者起搏诱发心肌病的预测因素
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/pt024-3444
E. O. Perepeka, O. Trembovetska, B. Kravchuk, I. Nastenko, M. Sychyk
Right ventricular pacing may impair left ventricular systolic function in patients with reduced left ventricular ejection fraction (LVEF). The aim. To determine the frequency of pacing-induced cardiomyopathy (PICM) in patients with permanent right ventricular pacing (at least 90%) and preserved LVEF (≥50%). To determine the risk factors for the occurrence of PICM. Materials and methods. The study included 34 patients with indications for permanent ventricular pacing in whom pacemaker was implanted from 2012 to 2022 (mean follow-up period 44.97 ± 28.45 months). PICM was defined as a decrease in LVEF <45% during follow-up regardless of clinical manifestations. Risk factors for PICM were determined through univariate and multivariate regression analysis. Results. The incidence of PICM in this study was 26% during the mean observation period of 44.9 ± 28.4 months. The mean time to the onset of PICM was 29 months in 5 out of 9 patients (55%), the time from implantation to diagnosis of PICM was less than a year. The mean LVEF and end-diastolic volume index at the time of follow-up differed significantly in the groups with and without PICM: 38.6 ± 5.9% vs. 53.5 ± 5.7% (p<0.001) and 97.9 ± 20.75 ml/m2 vs. 60.9 ± 19.32 ml/m2 (p<0.001), respectively. In the PICM group intraventricular asynchrony was 261.1 ± 61 ms vs. 146.1 ± 62.8 ms (p<0.001), interventricular asynchrony 91 ± 36.4 ms vs. 54.2 ± 22.2 ms (p = 0.014), the number of segments with reduced deformation 8.1 ± 2.6 vs. 3.91 ± 2.3 (p<0.001), global longitudinal strain –9.7 ± 2.6 % vs. –14.9 ± 3.4 % (p<0.001). At the time of the follow-up examination, the signal of sensitivity on ventricular lead in the PICM group was significantly reduced compared to patients without PICM (6.26 ± 4.02 mV vs. 11.56 ± 3.86 mV, p = 0.045). Paced QRS width in the PICM group was significantly larger (163 ± 22.7 ms vs. 150.8 ± 14.5 ms) and there were more patients with rate-adapted cardiac pacing in the PICM group: 4 (40%) vs. 2 (8%) (p = 0.0428). In multivariate regression analysis, a wider paced QRS (hazard ratio 1.09 for every 1 ms increment in QRS width, 95% confidence interval 1.01-1.17, p = 0.025) was an independent predictor of PICM. In two patients from PICM group, upgrade of pacemaker system to biventricular pacing was performed with an improvement in the left ventricular contractility: in one patient from 37% to 44%, in another from 34% to 51% in one and two month, respectively. Conclusions. Cardiomyopathy due to right ventricular pacing tends to occur instantaneously in the first years after pacemaker implantation, rather than slowly progressing over time. A wider paced QRS complex is an independent predictor of PICM. Biventricular pacing effectively eliminates the consequences of non-physiological right ventricular pacing, improves left ventricular systolic function.
左心室射血分数(LVEF)降低的患者右心室起搏可能损害左心室收缩功能。的目标。确定永久性右心室起搏(至少90%)和LVEF保存(≥50%)患者起搏性心肌病(PICM)的发生频率。确定PICM发生的危险因素。材料和方法。本研究纳入2012年至2022年34例植入起搏器的有适应证的永久性心室起搏患者(平均随访时间44.97±28.45个月)。无论临床表现如何,PICM定义为随访期间LVEF下降<45%。通过单因素和多因素回归分析确定PICM的危险因素。结果。PICM的发生率为26%,平均观察时间为44.9±28.4个月。9例患者中有5例(55%)发生PICM的平均时间为29个月,从植入到诊断PICM的时间少于1年。随访时,有PICM组和无PICM组的平均LVEF和舒张末期容积指数分别为38.6±5.9% vs. 53.5±5.7% (p<0.001)和97.9±20.75 ml/m2 vs. 60.9±19.32 ml/m2 (p<0.001)。PICM组脑室内不同步时间为261.1±61 ms vs. 146.1±62.8 ms (p<0.001),室间不同步时间为91±36.4 ms vs. 54.2±22.2 ms (p = 0.014),变形减少节段数为8.1±2.6 vs. 3.91±2.3 (p<0.001),整体纵向应变为-9.7±2.6% vs. -14.9±3.4% (p<0.001)。随访检查时,PICM组心室导联敏感信号较未PICM组明显降低(6.26±4.02 mV vs. 11.56±3.86 mV, p = 0.045)。PICM组节律性QRS宽度(163±22.7 ms vs 150.8±14.5 ms)明显大于PICM组,PICM组心率适应心脏起搏患者较多:4例(40%)vs 2例(8%)(p = 0.0428)。在多变量回归分析中,更宽的QRS (QRS宽度每增加1 ms,风险比为1.09,95%置信区间为1.01-1.17,p = 0.025)是PICM的独立预测因子。PICM组的2例患者将起搏器系统升级为双心室起搏后,左心室收缩力分别在1个月和2个月内从37%提高到44%,另一例从34%提高到51%。结论。由于右心室起搏引起的心肌病往往在起搏器植入后的头几年立即发生,而不是随着时间的推移缓慢发展。较宽的QRS复合体是PICM的独立预测因子。双室起搏有效消除非生理性右室起搏的后果,改善左室收缩功能。
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引用次数: 0
The First Local Experience of Use of Extracorporeal Circulatory Support with PROTEKDuo Dual-Lumen Cannula in a Patient with Acute Right Ventricular Failure PROTEKDuo双腔插管应用体外循环支持治疗急性右心室衰竭的首次局部经验
Q4 Medicine Pub Date : 2023-06-26 DOI: 10.30702/ujcvs/23.31(02)/dp027-4549
Oleksandr M. Dovgan, Maksim E. Paulouski, Alona I. Honcharenko, Anton V. Makedon, Y. V. Prystaia
Acute right ventricular failure is a life-threatening condition that can occur as a result of a sudden increase in total pulmonary vascular resistance, in particular, as a result of pulmonary embolism. Most patients with thromboembolism are treated with thrombolytic therapy, but in some cases open thrombextraction is preferred. Removal of blood clots from the pulmonary vascular bed and cardiopulmonary bypass can lead to spasm of the pulmonary artery and to the elevation of total pulmonary resistance, which, in turn, increases the afterload on the right ventricle and can lead to a dramatic decrease in its mechanical function. The aim. The aim of this report is to present the first experience of using the right ventricular bypass with the PROTEKDuo cannula for the purpose of temporary mechanical support of the right ventricle. Case presentation. We studied a 63-year-old patient who underwent Studer technique for bladder adenocarcinoma. On the 14th day an acute massive pulmonary embolism occurred with a drop in hemodynamics and the presence of a floating clot on the right atrium. Thrombolysis carried significant risks due to possible bleeding and clot fragmentation in the right atrium with subsequent embolization of the pulmonary arteries. In these circumstances, open thrombectomy under hypothermic arrest was performed. Intraoperatively, the patient developed acute right ventricular failure resistant to all conservative therapy, therefore, right ventricular bypass was connected using PROTEKDuo, which made it possible to overcome the phenomena of acute right ventricular failure in the postoperative period. Conclusions. Our experience with right ventricular bypass using the PROTEKDuo dual-lumen cannula demonstrates another useful option for saving patients with isolated right ventricular failure.
急性右心室衰竭是一种危及生命的疾病,可由于肺血管总阻力的突然增加而发生,特别是由于肺栓塞。大多数血栓栓塞患者采用溶栓治疗,但在某些情况下,开放血栓提取是首选。从肺血管床清除血块和体外循环可导致肺动脉痉挛和肺总阻力升高,这反过来又增加了右心室的后负荷,并可导致其机械功能急剧下降。的目标。本报告的目的是介绍首次使用PROTEKDuo套管进行右心室旁路的经验,目的是为右心室提供临时机械支持。案例演示。我们研究了一位63岁的患者,他接受了膀胱腺癌的Studer技术。第14天发生急性大面积肺栓塞,血流动力学下降,右心房出现浮动凝块。由于右心房可能出现出血和血栓碎裂,随后肺动脉栓塞,溶栓具有显著的风险。在这种情况下,在低温停搏下进行切开取栓。术中患者出现急性右心室衰竭,对所有保守治疗均无效,因此采用PROTEKDuo连接右心室旁路,克服了术后急性右心室衰竭的现象。结论。我们使用PROTEKDuo双腔插管进行右心室旁路的经验表明,这是拯救孤立性右心室衰竭患者的另一种有效选择。
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Ukrayins''kii zhurnal sertsevosudinnoyi khirurgiyi
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