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Recent Improvements in the Treatment of High-Risk Thyroid Cancer 高危甲状腺癌治疗的最新进展
Pub Date : 2022-05-30 DOI: 10.21593/kjhno/2022.38.1.1
E. Lee
Thyroid cancer is one of the slow-growing tumors with excellent oncological outcomes. However, a small set of patients with unexpectedly severe outcomes are usually ignored. Anaplastic thyroid cancer (ATC) remains one of the most aggressive and lethal solid tumors. Recently, dabrafenib and trametinib combination therapy or neoadjuvant BRAF induction therapy has shown promising results. In addition, a combination of targeted drugs, immunotherapy, surgery, and radiation therapy can improve overall survival in ATC patients. Another disease for which there is no breakthrough treatment is radioactive iodine-refractory differentiated thyroid cancer (DTC). To date, multikinase inhibitors (sorafenib, lenvatinib) targeting the growth factor signaling pathway have been developed and approved as anticancer agents for patients with advanced DTC. This review includes results from multikinase inhibitors to the emergence of new target molecules, including rearrangements during transformation (RET) and tropomyosin receptor kinase (TRK).
甲状腺癌是一种生长缓慢但预后良好的肿瘤。然而,有一小部分出人意料的严重后果的患者通常被忽视。间变性甲状腺癌(ATC)是最具侵袭性和致死性的实体肿瘤之一。最近,达非尼与曲美替尼联合治疗或新辅助BRAF诱导治疗显示出良好的效果。此外,结合靶向药物、免疫治疗、手术和放射治疗可以提高ATC患者的总生存率。另一种没有突破性治疗方法的疾病是放射性碘难治性分化甲状腺癌(DTC)。迄今为止,靶向生长因子信号通路的多激酶抑制剂(sorafenib, lenvatinib)已被开发并批准作为晚期DTC患者的抗癌药物。本文综述了从多激酶抑制剂到新靶标分子的出现,包括转化过程中的重排(RET)和原肌球蛋白受体激酶(TRK)。
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引用次数: 0
Intrathyroid Thyroglossal Duct Cyst Extending into the Mediastinum: A Case Report and Review of Literature 甲状腺内甲状舌管囊肿延伸至纵隔1例报告及文献复习
Pub Date : 2022-05-30 DOI: 10.21593/kjhno/2022.38.1.65
C. Lee, Y. Hong
Thyroglossal duct cyst (TGDC) is the most common congenital cyst in the neck and usually presents in children. It is most commonly located at the infrahyoid level. However, intrathyroid TGDC in the adult is extremely rare and its pathogenesis remains unclear. Curiously, an intrathyroid TGDC was found on the lateral aspect of the inferior pole of the thyroid gland. Given the unique position of this lesion, and its capacity to stimulate other nodules in the thyroid, it should be differentiated from other lateral neck masses, such as: thymic cysts, branchial cleft cysts, cystic hygroma, lipomas, lymphadenopathies, cervical teratomas, and lymphomas. In this case, a separate cystic mass was found in the right inferior pole of the thyroid gland and extended to the mediastinum. We confirmed it as TGDC by pathology and histological examination.
甲状舌管囊肿(TGDC)是最常见的先天性颈部囊肿,多见于儿童。它最常位于舌骨下水平。然而,成人甲状腺内TGDC极为罕见,其发病机制尚不清楚。奇怪的是,在甲状腺下极的外侧发现了甲状腺内TGDC。鉴于该病变的独特位置及其刺激甲状腺其他结节的能力,应将其与其他侧颈部肿块区分开来,如:胸腺囊肿、鳃裂囊肿、囊性水瘤、脂肪瘤、淋巴结病、宫颈畸胎瘤和淋巴瘤。在本例中,在甲状腺右下极发现一个单独的囊性肿块,并延伸到纵隔。经病理及组织学检查证实为TGDC。
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引用次数: 0
Clinico-pathologic Factors and Machine Learning Algorithm for Survival Prediction in Parotid Gland Cancer 临床病理因素与机器学习算法在腮腺癌存活预测中的应用
Pub Date : 2022-05-30 DOI: 10.21593/kjhno/2022.38.1.17
Seung Min Park, Se-Heon Kim, E. Choi, J. Lim, Y. Koh, Y. M. Park
Background/Objectives: This study analyzed the prognostic significance of clinico-pathologic factors including comprehensive nodal factors in parotid gland cancers (PGCs) patients and constructed a survival prediction model for PGCs patients using machine learning techniques.Materials & Methods: A total of 131 PGCs patients were enrolled in the study.Results: There were 19 cases (14.5%) of lymph nodes (LNs) at the lower neck level and 43 cases (32.8%) involved multiple level LNs metastases. There were 2 cases (1.5%) of metastases to the contralateral LNs. Intraparotid LNs metastasis was observed in 6 cases (4.6%) and extranodal extension (ENE) findings were observed in 35 cases (26.7%). Lymphovascular invasion (LVI) and perineural invasion findings were observed in 42 cases (32.1%) and 49 cases (37.4%), respectively. Machine learning prediction models were constructed using clinico-pathologic factors including comprehensive nodal factors and Decision Tree and Stacking model showed the highest accuracy at 74% and 70% for predicting patient’s survival.Conclusion: Lower level LNs metastasis and LNR have important prognostic significance for predicting disease recurrence and survival in PGCs patients. These two factors were used as important features for constructing machine learning prediction model. Our machine learning model could predict PGCs patient’s survival with a considerable level of accuracy.
背景/目的:本研究分析腮腺癌(pgc)患者综合淋巴结因素等临床病理因素对预后的影响,并利用机器学习技术构建pgc患者生存预测模型。材料与方法:共有131例PGCs患者入组研究。结果:下颈部淋巴结19例(14.5%),多发性淋巴结转移43例(32.8%)。2例(1.5%)转移至对侧LNs。6例(4.6%)出现腮腺内LNs转移,35例(26.7%)出现结外延伸(ENE)。淋巴血管侵犯(LVI) 42例(32.1%),神经周围侵犯49例(37.4%)。采用综合节点因素和决策树等临床病理因素构建机器学习预测模型,堆叠模型预测患者生存的准确率最高,分别为74%和70%。结论:低水平的LNs转移和LNR对预测PGCs患者的疾病复发和生存具有重要的预后意义。将这两个因素作为构建机器学习预测模型的重要特征。我们的机器学习模型可以相当准确地预测PGCs患者的生存。
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引用次数: 1
A Case of Parathyroid Carcinoma with Spontaneous Infarction 甲状旁腺癌合并自发性梗死1例
Pub Date : 2022-05-30 DOI: 10.21593/kjhno/2022.38.1.25
Sang-Yen Geum, H. Park, J. Yoo, Jeong Kyu Kim, Dong Won Lee
Parathyroid carcinoma is very rare malignant neoplasm, accounting for less than 0.005% of all cancers. Most parathyroid carcinoma is a functioning tumor that causes hyperparathyroidism, leading to hypercalcemia. We report a parathyroid carcinoma case that was suspicious for spontaneous infarction of cancer, leading to resolution of hypercalcemia. A 29-year-old male visited our hospital presenting with right neck swelling and pain. He has been experiencing frequent urolithiasis for four years but laboratory tests showed normal serum calcium level. Right vocal cord paresis was identified with laryngoscopy. Ultrasonography revealed a 3.7 × 3.5 cm mass in the right thyroid containing a focal cystic portion. Computed tomography confirmed the presence of a low-density right thyroid mass. Right thyroid lobectomy was performed and pathological evaluation revealed parathyroid carcinoma with central necrosis. We report this very rare case with a literature review.
甲状旁腺癌是一种非常罕见的恶性肿瘤,占所有癌症的不到0.005%。大多数甲状旁腺癌是一种功能性肿瘤,可引起甲状旁腺功能亢进,导致高钙血症。我们报告一个甲状旁腺癌的病例,怀疑自发性梗死的癌症,导致高钙血症的解决。一名29岁男性以右颈部肿胀疼痛就诊。四年来,他经常出现尿石症,但实验室检查显示血钙水平正常。右声带轻瘫经喉镜检查确诊。超声检查显示右侧甲状腺有一个3.7 × 3.5 cm的肿块,包含局灶性囊性部分。计算机断层扫描证实右侧甲状腺低密度肿块。行右侧甲状腺叶切除术,病理检查显示甲状旁腺癌伴中央坏死。我们报告这个非常罕见的病例,并进行文献回顾。
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引用次数: 0
A Case of Postoperative Silicone Magnet Compression Treatment of Pseudocyst in the Ear 硅胶磁体压迫治疗耳内假性囊肿1例
Pub Date : 2022-05-30 DOI: 10.21593/kjhno/2022.38.1.69
Seong Hoon Seol, C. Chung, M. Park
Endochondral pseudocyst of the ear is a rare, benign, non-inflammatory cystic disease. It is known that there are a variety of treatment methods for pseudocyst, which is mainly common in the scaphoid or triangular fossa of the ear. Pseudocyst formation is prevalent in the residual cavity of the ear. So, to prevent a recurrence, a surgical approach is also required, but management through compression is necessary after surgery. Applying a cube magnet to the lesion to press provides patient convenience and facilitates continuous management.
耳软骨内假性囊肿是一种罕见的良性、非炎症性囊性疾病。据了解,假性囊肿的治疗方法多种多样,主要见于舟状骨或耳三角窝。假性囊肿常见于耳腔。因此,为了防止复发,手术方法也是必要的,但术后通过压迫治疗是必要的。在病灶处应用立方体磁铁进行按压,为患者提供了方便,便于持续治疗。
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引用次数: 0
Clinical Benefit of Vaccinating Male Against HPV-related Disease 男性接种hpv相关疾病疫苗的临床效益
Pub Date : 2022-05-30 DOI: 10.21593/kjhno/2022.38.1.11
Sei-Young Lee
HHPV (Human Papillomavirus) is a DNA virus that can cause benign lesions, genitourinary cancer, and oropharyngeal cancer by penetrating the mucous membrane and skin. It is widely known to be transmitted mainly through sexual contact. As with many viral infections, vaccines have been developed to prevent infection with HPV. Currently, in many countries, HPV vaccines are mainly used for national immunization for women to prevent diseases that traditionally occur frequently in women, especially cervical cancer. However, since the vaccination rate is relatively low, many countries are struggling with ways to increase the vaccination rate. Meanwhile, the incidence of oropharyngeal cancer caused by HPV in men has been increasing recently. In the United States, the annual number of oropharyngeal cancers in men already exceeds the number of cervical cancers in women, so HPV infection in men has emerged as a major problem. Accordingly, interest in HPV vaccination in men has also increased, and studies on the effectiveness and necessity of vaccination of both women and men compared to women alone are being actively conducted. In this paper, the evidence of HPV vaccination for men will be reviewed through previous studies, and its validity and cost-effectiveness will be analyzed to bolster the clinical usefulness of HPV vaccination for men.
HHPV(人乳头瘤病毒)是一种DNA病毒,可通过穿透粘膜和皮肤引起良性病变、泌尿生殖系统癌和口咽癌。众所周知,它主要通过性接触传播。与许多病毒感染一样,已经开发出预防HPV感染的疫苗。目前,在许多国家,人乳头瘤病毒疫苗主要用于妇女的全国免疫,以预防传统上在妇女中经常发生的疾病,特别是宫颈癌。然而,由于疫苗接种率相对较低,许多国家正在努力寻找提高疫苗接种率的方法。同时,HPV引起的男性口咽癌的发病率近年来呈上升趋势。在美国,每年男性口咽癌的数量已经超过了女性宫颈癌的数量,因此男性HPV感染已经成为一个主要问题。因此,对男性接种人乳头瘤病毒疫苗的兴趣也有所增加,目前正在积极开展关于女性和男性接种疫苗的有效性和必要性的研究,而不是单独接种女性疫苗。本文将通过以往的研究回顾男性HPV疫苗接种的证据,并分析其有效性和成本效益,以加强男性HPV疫苗接种的临床应用。
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引用次数: 0
A Case of Carcinoma with Sebaceous Differentiation arising in the Patient who was Treated with Parotid Gland Adenocarcinoma 腮腺腺癌治疗后出现皮脂腺分化癌1例
Pub Date : 2022-05-30 DOI: 10.21593/kjhno/2022.38.1.37
Sohl Park, J. Yun, Yu-Jin Go, Soo-Yeon Jung
Sebaceous carcinoma is extremely rare in the parotid gland. Recently, we experienced a case of carcinoma with sebaceous differentiation arising from the parotid gland in patient who was diagnosed as parotid adenoma carcinoma and underwent total parotidectomy.A 73-year-old male visited our department for the evaluation of 3-month history of infra-auricular mass combined with pain. Radiologic finding showed lobulated enhancing and solid mass with calcification in the right parotid gland. Initially, total parotidectomy with supraomohyoid neck dissection was performed. Pathological findings showed capsulated whitish mass with hemorrhage and cystic degeneration. Immunohistochemically, CK7, CK5/6, p63 were positive and CEA was negative. The intra-operative frozen section diagnosis was mucoepidermoid carcinoma. The permanent diagnosis was changed to adenocarcinoma, NOS(not otherwise specified). Fourteen months later, the newly developed mass was noticed on the operation bed. The mass was clinically diagnosed as recurred adenocarcinoma. Revision parotidectomy was performed and pathological findings revealed that the tumor was newly developed sebaceous carcinoma. We report a case of carcinoma with sebaceous differentiation in parotid gland with a review of literature.
皮脂腺癌在腮腺中极为罕见。最近,我们报告了一例由腮腺引起的皮脂腺分化癌,患者被诊断为腮腺腺瘤癌并行腮腺全切除术。一名73岁男性来我科评估其3个月耳下肿块合并疼痛病史。放射学表现为右侧腮腺分叶状强化及实性肿块伴钙化。最初,我们进行了腮腺全切除术和肩胛舌骨上颈清扫术。病理表现为包膜状白色肿块,伴有出血和囊性变性。免疫组化结果显示,CK7、CK5/6、p63阳性,CEA阴性。术中冰冻切片诊断为粘液表皮样癌。永久诊断改为腺癌,NOS(未另行说明)。14个月后,在手术床上发现了新形成的肿块。临床诊断为复发性腺癌。病理结果显示肿瘤为新发皮脂腺癌。我们报告一例腮腺皮脂腺分化癌,并复习文献。
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引用次数: 0
A Case of Solitary Metastatic Deposit in the Orbital Rim from Follicular Thyroid Cancer 滤泡性甲状腺癌眼眶缘单发转移沉积1例
Pub Date : 2021-11-30 DOI: 10.21593/kjhno/2021.37.2.105
Gyeong Hwa Jeon, Hyeon Seok Oh, I. Choi, H. Byeon
Follicular thyroid carcinoma (FTC) is the second most common thyroid cancer, following papillary carcinoma. Metastasis to the orbital rim from FTC is very rare. We recently experienced a case of FTC with metastasis to the orbital rim in a 74-year-old woman, who initially presented with a huge thyroid mass and an asymptomatic solitary orbital rim lesion. The solitary orbital rim lesion was suspected to be a separate disease entity such as lymphoma from the preoperative imaging, but bone metastasis from FTC was finally confirmed after orbital rim resection and total thyroidectomy. During follow-up, the patient presented multiple bone metastasis, so the solitary orbital rim lesion was considered a clinical sign of systemic metastasis from FTC. Therefore, we present this unique case with a review of the literature.
滤泡性甲状腺癌(FTC)是继乳头状癌之后第二常见的甲状腺癌。从FTC转移到眶缘是非常罕见的。我们最近收治了一例74岁女性FTC伴眶缘转移的病例,她最初表现为巨大的甲状腺肿块和无症状的孤立性眶缘病变。术前影像学怀疑孤立性眶缘病变为淋巴瘤等单独的疾病实体,但在眶缘切除术和甲状腺全切除术后,最终证实FTC骨转移。在随访期间,患者出现多发骨转移,因此孤立的眶缘病变被认为是FTC全身转移的临床征象。因此,我们提出这个独特的情况下,回顾文献。
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引用次数: 0
A Case of Lymphoepithelial Carcinoma Originating in the Submandibular Gland 起源于颌下腺的淋巴上皮癌1例
Pub Date : 2021-11-30 DOI: 10.21593/kjhno/2021.37.2.81
S. Kim, G. Kim, H. Shin, Dong-Il Sun
Lymphoepithelial carcinoma is an extremely rare malignant tumor, especially those localized at the head and neck region. The histological prototype of lymphoepithelial carcinoma is undifferentiated nasopharyngeal carcinoma. Herein, we report a case of a tumor localized in the left submandibular gland in a 20-year-old male. The tumor mass was surgically excised with the submandibular gland, and the specimen was pathologically confirmed to be lymphoepithelial carcinoma.
淋巴上皮癌是一种极为罕见的恶性肿瘤,尤其是局限于头颈部的肿瘤。淋巴上皮癌的组织学原型为未分化鼻咽癌。在此,我们报告一例肿瘤定位于左侧下颌腺在一个20岁的男性。肿瘤肿块与下颌骨腺一起手术切除,标本病理证实为淋巴上皮癌。
{"title":"A Case of Lymphoepithelial Carcinoma Originating in the Submandibular Gland","authors":"S. Kim, G. Kim, H. Shin, Dong-Il Sun","doi":"10.21593/kjhno/2021.37.2.81","DOIUrl":"https://doi.org/10.21593/kjhno/2021.37.2.81","url":null,"abstract":"Lymphoepithelial carcinoma is an extremely rare malignant tumor, especially those localized at the head and neck region. The histological prototype of lymphoepithelial carcinoma is undifferentiated nasopharyngeal carcinoma. Herein, we report a case of a tumor localized in the left submandibular gland in a 20-year-old male. The tumor mass was surgically excised with the submandibular gland, and the specimen was pathologically confirmed to be lymphoepithelial carcinoma.","PeriodicalId":336823,"journal":{"name":"Korean Society for Head and Neck Oncology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125237899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Outcome of Extracapsular Dissection of Benign Parotid Gland Tumor: A Comparative Study to Superficial Parotidectomy 良性腮腺肿瘤囊外夹层与腮腺浅表切除术的疗效比较
Pub Date : 2021-11-30 DOI: 10.21593/kjhno/2021.37.2.51
Y. Kim, Chang Hoi Kim, H. Lee, K. Lee, Sungwon Kim
Background/Objectives: Extracapsular dissection has the advantage of reducing complications by minimizing tissue loss of the parotid without intentionally exposing the facial nerve in patients with benign parotid tumor. However, there has been controversy over the surgical results. Thus, the surgical outcomes of extracapsular dissection for benign parotid tumor was compared to those of superficial parotidectomy.Materials & Methods: A retrospective chart review was conducted with 132 patients who received surgery for benign parotid tumor in our center from January 2014 to December 2018 retrospectively.Results: A total of 132 people were enrolled, with 62 people receiving extracapsular dissection, 38 people receiving partial superficial parotidectomy and 32 people receiving superficial parotidectomy. No significant difference was found between the three groups regarding complications such as facial nerve palsy, Frey's syndrome, or first bite syndrome. Operation time and hospital stay was significantly short in extracapsular dissection group.Conclusion: For well-selected cases, extracapsular dissection can be considered as an option for surgery of benign parotid tumor.
背景/目的:在腮腺良性肿瘤患者中,囊外剥离术可以减少腮腺组织损失,减少并发症,而无需故意暴露面神经。然而,对手术结果一直存在争议。因此,我们比较了腮腺良性肿瘤的囊外剥离术与腮腺浅表切除术的手术效果。材料与方法:回顾性分析我院2014年1月至2018年12月行腮腺良性肿瘤手术治疗的132例患者的资料。结果:共纳入132例患者,其中62例接受囊外剥离,38例接受部分腮腺浅表切除术,32例接受腮腺浅表切除术。在面神经麻痹、弗雷氏综合征或首次咬伤综合征等并发症方面,三组间无显著差异。囊外剥离组手术时间和住院时间均明显缩短。结论:对于选择性好的腮腺良性肿瘤,可考虑采用囊外剥离术。
{"title":"Surgical Outcome of Extracapsular Dissection of Benign Parotid Gland Tumor: A Comparative Study to Superficial Parotidectomy","authors":"Y. Kim, Chang Hoi Kim, H. Lee, K. Lee, Sungwon Kim","doi":"10.21593/kjhno/2021.37.2.51","DOIUrl":"https://doi.org/10.21593/kjhno/2021.37.2.51","url":null,"abstract":"Background/Objectives: Extracapsular dissection has the advantage of reducing complications by minimizing tissue loss of the parotid without intentionally exposing the facial nerve in patients with benign parotid tumor. However, there has been controversy over the surgical results. Thus, the surgical outcomes of extracapsular dissection for benign parotid tumor was compared to those of superficial parotidectomy.Materials & Methods: A retrospective chart review was conducted with 132 patients who received surgery for benign parotid tumor in our center from January 2014 to December 2018 retrospectively.Results: A total of 132 people were enrolled, with 62 people receiving extracapsular dissection, 38 people receiving partial superficial parotidectomy and 32 people receiving superficial parotidectomy. No significant difference was found between the three groups regarding complications such as facial nerve palsy, Frey's syndrome, or first bite syndrome. Operation time and hospital stay was significantly short in extracapsular dissection group.Conclusion: For well-selected cases, extracapsular dissection can be considered as an option for surgery of benign parotid tumor.","PeriodicalId":336823,"journal":{"name":"Korean Society for Head and Neck Oncology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130031647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Korean Society for Head and Neck Oncology
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