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Nevoid Basal Cell Carcinoma Syndrome on Scalp: A Rare Case Report 头皮上的痣样基底细胞癌综合征:罕见病例报告
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.19
C. Chung, Yu Chan Lee, Jae Hyun Kim, Myong Chul Park
Nevoid basal cell carcinoma syndrome is a rare disease that can be accompanied by various clinical symptoms in addition to basal cell carcinoma. Cancers usually occur at an earlier age or later in multiple areas. According to a recent study, genetic mutations are highly suspected as the cause of the syndrome. Since this gene mutation is inherited as an autosomal dominant, it must be accompanied by a screening test for the patient's family along with the patient's treatment. In this study, we was experienced a patient diagnosed with nevoid basal cell carcinoma syndrome after genetic mutation was confirmed, so it is reported along with a review of the literature.
痣样基底细胞癌综合征是一种罕见疾病,除基底细胞癌外,还可伴有各种临床症状。癌症通常发生在较早的年龄或较晚的多个部位。根据最近的一项研究,基因突变被高度怀疑是该综合征的病因。由于这种基因突变是常染色体显性遗传,因此在对患者进行治疗的同时,还必须对患者家属进行筛查。在本研究中,我们遇到了一名经基因突变确诊为痣样基底细胞癌综合征的患者,因此在报告该患者情况的同时,也对文献进行了回顾。
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引用次数: 0
A Case of Diffuse Large B-cell Lymphoma Transformed from Primary Thyroid MALT Lymphoma 由原发性甲状腺 MALT 淋巴瘤转化而来的弥漫大 B 细胞淋巴瘤病例
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.13
Youngrok Jo, Youn Jin Cho, Ju Yeon Pyo, Hye Ran Lee
Diffuse large B cell lymphoma (DLBCL) is main subtype of primary thyroid lymphoma and can be histologically transformed from a low-grade B-cell lymphoma. The characteristics and treatment guidelines of these particular DLBCL have not been fully established. The mainstay of treatment of primary thyroid DLBCL is multimodality treatment with chemotherapy and radiotherapy. Meanwhile, surgery can be considered only for diagnosis or alleviation of airway compressive symptoms.A 57-year-old female visited our outpatient clinic for recently enlarged long-held anterior neck mass. A thyroid mass compressing the airway and esophagus was identified on imaging, which was diagnosed as MALT lymphoma by excisional biopsy. After staging, the patient underwent total thyroidectomy with regional lymph node dissection for treatment of stage IIE MALT lymphoma and relieving airway compromise symptoms. The final diagnosis was DLBCL transformed from MALT Lymphoma, and chemotherapy was additionally performed. We report this rare experience with a review of literature.
弥漫大B细胞淋巴瘤(DLBCL)是原发性甲状腺淋巴瘤的主要亚型,在组织学上可由低级别B细胞淋巴瘤转变而来。这些特殊DLBCL的特征和治疗指南尚未完全确定。原发性甲状腺DLBCL的主要治疗方法是化疗和放疗等多模式治疗。一位57岁的女性患者因颈部前部肿块长期增大而到我院门诊就诊。影像学检查发现甲状腺肿块压迫气道和食道,经切除活检确诊为MALT淋巴瘤。分期后,患者接受了甲状腺全切除术和区域淋巴结清扫术,以治疗 IIE 期 MALT 淋巴瘤并缓解气道受损症状。最终诊断为由 MALT 淋巴瘤转化而来的 DLBCL,并进行了化疗。我们报告了这一罕见病例,并回顾了相关文献。
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引用次数: 0
Minimally Invasive Parathyroidectomy using Intraoperative Ultrasonography in Parathyroid Adenoma Patients with a History of Total Thyroidectomy 在有甲状腺全切除术史的甲状旁腺腺瘤患者中使用术中超声微创甲状旁腺切除术
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.27
Yunbin Nam, Hyun Taek Jung, Sang Mok Lee, Ji-Hoon Kim
A 65-year-old patient who underwent total thyroidectomy 10 years ago was suspected of having a parathyroid adenoma, and minimally invasive parathyroidectomy was planned. Preoperative ultrasonography(USG) and 99mTc MIBI scan indicated a left lower parathyroid lesion. In the first operation, intraoperative parathyroid hormone monitoring (IOPTH) was not possible due to hospital circumstances. Although no adenomatous lesion was found in the expected surgical field, surgery was completed after removing lesions around the left lower parathyroid gland. However, post-surgery, parathyroid hormone did not decrease at all, so a second operation was performed with IOPTH preparation. In the second operation, intraoperative ultrasonography was performed, and a suspected adenoma lesion was removed from the left upper lesion. He has been under follow-up for 3 years without complications. Surgeon-peformed intraoperative USG and preoperative scintigraphy had advantages in determining the localization of parathyroid lesion even withiout IOPTH.
一位65岁的患者曾在10年前接受过甲状腺全切除术,现被怀疑患有甲状旁腺腺瘤,因此计划进行微创甲状旁腺切除术。术前超声波(USG)和 99mTc MIBI 扫描显示左下甲状旁腺病变。在第一次手术中,由于医院条件限制,无法进行术中甲状旁腺激素监测(IOPTH)。虽然在预期的手术区域内没有发现腺瘤病变,但在切除左下甲状旁腺周围的病变后,手术还是完成了。然而,手术后甲状旁腺激素却丝毫没有下降,因此在准备 IOPTH 的情况下进行了第二次手术。在第二次手术中,进行了术中超声检查,并从左上方病灶中切除了一个疑似腺瘤的病灶。他已接受随访 3 年,未出现并发症。由外科医生实施的术中超声检查和术前闪烁照相术在确定甲状旁腺病变的定位方面具有优势,即使没有IOPTH也是如此。
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引用次数: 0
A Case of Early Malignant Change from Neurofibroma to Malignant Peripheral Nerve Sheath Tumor 一例从神经纤维瘤到恶性周围神经鞘瘤的早期恶变病例
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.45
Poo Reum Kang, Y. Kim, Sun Ju Oh, H. Lee
Malignant peripheral nerve sheath tumor (MPNST) is one of the soft tissue sarcoma believed to originate from neural crest cells. The patients with neurofibromatosis type I (NF1) have about 8-13% of the lifetime risk of the malignant transformation. Neurofibroma on patients with NF1 can be surgically resected and has good prognosis if approach to the tumor is possible. We experienced a case of a 50-year-old woman with NF who had incompletely resected neurofibroma, which presented a rapid malignant transformation to MPNST, 3 months after the first surgery. We reported this case with a brief review of literature.
恶性周围神经鞘瘤(MPNST)是软组织肉瘤的一种,被认为起源于神经嵴细胞。I 型神经纤维瘤病(NF1)患者一生中发生恶性转化的风险约为 8-13%。NF1患者的神经纤维瘤可以通过手术切除,如果能够接近肿瘤,预后良好。我们曾接诊过一例 50 岁的 NF 女性患者,她的神经纤维瘤未完全切除,在首次手术后 3 个月迅速恶变为 MPNST。我们报告了这一病例,并简要回顾了相关文献。
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引用次数: 0
Mucosal Roofing Flap Reconstruction to Minimize Horizontal Lip Length Loss and Preserve Mouth Opening in Lower Lip Squamous Cell Carcinoma 下唇鳞状细胞癌患者的粘膜屋顶瓣重建术,最大程度减少唇水平长度损失并保留张口功能
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.23
J. H. Kim, In Chang Koh, Soo Yeon Lim, Hoon Kim
Lower lip reconstruction in cases with a full-thickness defect over one-third of the vermilion is challenging. Numerous conventional techniques have been applied with unsatisfactory surgical outcomes because of microstomia and oral commissure blunting due to shortened horizontal lip length. Herein, we present a case in which a full-thickness lower lip defect of more than one-third of the horizontal lip length was covered with a novel mucosal roofing flap reconstruction to minimize the loss of horizontal lip length and to preserve mouth opening. No recurrences or metastases were observed during 3 years and 6 months of follow-up, with horizontal lower lip length maintained and mouth opening of 2.5 finger breadths.
对于朱唇三分之一以上全厚缺损的病例,下唇重建具有挑战性。由于水平唇长度缩短,导致小口和口腔交界处变钝,因此许多传统技术的手术效果并不理想。在本报告中,我们介绍了一个病例,该病例的下唇全厚缺损超过水平唇长的三分之一,采用新型粘膜屋顶瓣重建,最大程度地减少了水平唇长的损失,并保留了张口功能。在 3 年零 6 个月的随访中未发现复发或转移,下唇水平长度保持不变,口腔张开 2.5 指宽。
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引用次数: 0
A Case of Ewing’s Sarcoma Arising from Larynx 一例喉部尤文氏肉瘤病例
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.71
Dongkook Kim, Jun-Yong Lee, Young Kang, Seung Heon Kang
Ewing sarcoma is a rare tumor in head and neck area. We demonstrate a rare case of sinonasal Ewing sarcoma initially suspected as olfactory neuroblastoma. After the surgery and immunohistochemical studies, it was accurately diagnosed as Ewing sarcoma. We would like to emphasize the possibility that Ewing sarcoma may originate from the head and neck area, and hence, it is important to use appropriate techniques for accurate diagnosis and treatment.
尤文肉瘤是头颈部的一种罕见肿瘤。我们展示了一例罕见的鼻窦尤文肉瘤病例,起初怀疑是嗅神经母细胞瘤。经过手术和免疫组化检查后,被准确诊断为尤文肉瘤。我们要强调的是,尤文肉瘤可能起源于头颈部,因此,使用适当的技术进行准确诊断和治疗非常重要。
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引用次数: 0
Frailty in Geriatric Patients with Head and Neck Cancer and its Implication in Survivorship 老年头颈癌患者的虚弱状况及其对生存的影响
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.1
Minsu Kwon
The aging population, particularly those aged 65 and above, is on the rise, with projections indicating a substantial increase in the elderly demographic. This demographic shift brings challenges in managing age-related diseases, including head and neck cancers (HNCs). Frailty, often characterized by physiological decline and vulnerability to stressors, is a crucial factor affecting treatment outcomes of elderly cancer patients. Accordingly, the significance of assessing frailty in elderly HNC patients before their treatment should be emphasized, but current frailty assessment tools may not fully capture the unique challenges faced by HNC patients. Specific indicators, including respiratory and swallowing functions, are proposed for a more tailored assessment. This comprehensive review explores the impact of frailty on various treatment modalities, including surgery, radiation, and chemotherapy, highlighting the need for personalized interventions. Furthermore, it suggests avenues for future research to enhance frailty assessment tools and investigate interventions aimed at improving treatment outcomes in elderly HNC patients.
老龄化人口,尤其是 65 岁及以上的老年人口正在不断增加,预计老年人口将大幅增长。这种人口结构的变化给老年相关疾病(包括头颈部癌症)的治疗带来了挑战。虚弱通常以生理衰退和易受压力影响为特征,是影响老年癌症患者治疗效果的关键因素。因此,应强调在治疗前对老年 HNC 患者进行虚弱评估的重要性,但目前的虚弱评估工具可能无法完全反映 HNC 患者所面临的独特挑战。我们提出了包括呼吸和吞咽功能在内的特定指标,以便进行更有针对性的评估。本综述探讨了虚弱对手术、放疗和化疗等各种治疗方式的影响,强调了个性化干预的必要性。此外,它还提出了未来研究的方向,以加强虚弱评估工具,并研究旨在改善老年 HNC 患者治疗效果的干预措施。
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引用次数: 0
Case Report: Reconstruction of the Lower Lip using the Karapandzic Flap 病例报告:使用卡拉潘奇皮瓣重建下唇
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.75
Jun Sik Kim, Jae Bong Shin, N. Kim, Gi Cheol Do, M. Kim, Tae Ho Kim, Kyung Suk Lee
Squamous cell carcinoma of the lip is a common malignant tumor originating from oral cancer. However, unlike other areas, the lips hold significant functional and aesthetic importance as a part of the face. As a result, a tailored approach based on the tumor's size, type, and location is essential. The Karapandzic flap is especially suitable for reconstructing lesions located on the lip, particularly when the size of the cancer is large and other surgical treatments like free flaps are not feasible. It allows for extensive resection beyond the size of the lower lip. In this case, considering the patient's overall condition, successful reconstruction of the lower lip was achieved using the Karapandzic flap.
嘴唇鳞状细胞癌是一种常见的恶性肿瘤,源于口腔癌。然而,与其他部位不同的是,嘴唇作为面部的一部分,在功能和美观上都具有重要意义。因此,根据肿瘤的大小、类型和位置采取有针对性的方法至关重要。Karapandzic 皮瓣尤其适用于唇部病变的重建,特别是当癌症体积较大,而游离皮瓣等其他手术治疗方法又不可行时。它可以进行超过下唇大小的广泛切除。在这个病例中,考虑到患者的整体情况,使用卡拉潘季奇皮瓣成功地重建了下唇。
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引用次数: 0
Flap Reconstruction and Histological Review after Extensive Resection of Adult Type Fibrosarcoma 成人型纤维肉瘤广泛切除术后的皮瓣重建和组织学审查
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.7
Young Soo Yoon, Hojung Lee, Hye Kyung Lee
Adult fibrosarcoma is a malignant tumor comprising of spindle-shaped fibroblasts with variable collagen production. Due to their aggressive nature and high probability of local tumor recurrence, these tumors require accurate diagnosis and resection according to guidelines. A 57-year-old male presented to the clinic with a complaint of a palpable growing mass in the left scapular area. Examination of the back revealed a 6 cm protruding tumor with a nodular surface. We performed a wide excision, including the infraspinatus fascia layer and subsequent reconstruction using a parascapular island flap. Histopathological analysis demonstrated the typical microscopic features of adult fibrosarcoma. At the 3-year follow-up, there was no evidence of local recurrence and the resection margin was completely clear of tumor.
成人纤维肉瘤是一种恶性肿瘤,由纺锤形成纤维细胞组成,可产生不同的胶原蛋白。由于其侵袭性和局部复发的高概率,这类肿瘤需要根据指南进行准确诊断和切除。一名 57 岁的男性前来就诊,主诉左侧肩胛区可触及生长肿块。背部检查发现一个 6 厘米突出的肿瘤,表面呈结节状。我们对肿瘤进行了大范围切除,包括冈下筋膜层,随后使用肩胛旁岛状皮瓣进行了重建。组织病理学分析显示,该肿瘤具有成人纤维肉瘤的典型显微特征。三年随访时,没有发现局部复发的迹象,切除边缘也完全没有肿瘤。
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引用次数: 0
A Case of Hemangioma of Nasal Cavity in Von Hippel-Lindau Syndrome 冯-希佩尔-林道综合征鼻腔血管瘤病例
Pub Date : 2023-11-30 DOI: 10.21593/kjhno/2023.39.2.65
Hyun Seok Kang, Soo Jin Jung, S. Chae, Seok Jin Hong
We report a unique case of hemangioma of the nasal cavity in von Hippel-Lindau (VHL) syndrome. A 26-year-old female with VHL syndrome who had previously undergone surgery for pancreatic and adrenal mass presented with a 4-month history of left-sided nasal obstruction. The patient had an expansile mass lesion in the left nasal cavity and an imaging test demonstrated the mass in the left maxillary sinus extending to the nasal cavity. The tumor was removed with an endoscopic prelacrimal recess approach considering the possibility of not only a benign tumor such as hemangioma but also a malignant tumor of the maxillary sinus and histopathologic examination confirmed cavernous hemangioma. This case is the rarely reported manifestation of the paranasal sinus in VHL disease.
我们报告了一例独特的冯-希佩尔-林道(VHL)综合征鼻腔血管瘤病例。一名患有 VHL 综合征的 26 岁女性患者曾因胰腺和肾上腺肿块接受过手术,4 个月前出现左侧鼻腔阻塞。患者左侧鼻腔有一膨胀性肿块病变,影像学检查显示肿块位于左侧上颌窦,并延伸至鼻腔。考虑到不仅有可能是血管瘤等良性肿瘤,也有可能是上颌窦恶性肿瘤,因此采用内镜下泪囊前凹入路切除了肿瘤,组织病理学检查证实为海绵状血管瘤。本病例是 VHL 病中极少见的副鼻窦表现。
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引用次数: 0
期刊
Korean Society for Head and Neck Oncology
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