Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1553
T. Marushko, O.Ye. Onufreiv, Y. Marushko, O. German
Background. Juvenile idiopathic arthritis (JIA) is one of the most common rheumatological diseases of childhood. The central place in the problem of JIA belongs to the question of treatment the timeliness and adequacy of which determine the disease prognosis and, in fact, the entire future of the child. Immunobiological therapy can cause stable clinical and laboratory remission, as well as stop the further progression of structural changes, affecting the pathogenetic link of idiopathic arthritis. But the lack of response to therapy or a decrease in its effectiveness remains a fairly common problem and, in many cases, can be caused by the immunogenicity of immunobiological drugs, especially in case of treatment with tumor necrosis factor inhibitors. Aim of the work: to study the level of antibodies to adalimumab in children with juvenile idiopathic arthritis at different stages of treatment for analysis of immunogenicity. Materials and methods. The concentration of antibodies to adalimumab in 80 serum samples from patients with JIA was studied and evaluated, treatment effectiveness and adverse events were analyzed in 56 patients with JIA at different stages of therapy. Two groups were identified. The first one included 24 patients who had at least a 6-month break in adalimumab administration for non-medical reasons during which treatment was continued with methotrexate with periodic intra-articular injection of glucocorticoids. The level of antibodies to adalimumab was evaluated before the break and 1 month after the reinitiation of adalimumab administration. The second group consisted of 32 children who continued adalimumab without a break during treatment. Disease activity was measured using JADAS-27. Antibodies to adalimumab were detected by enzyme-linked immunosorbent assay. Results. During the examination, an elevated level of antibodies to adalimumab was detected in 10 of 24 serum samples (42 %) before non-medical withdrawal in group I. Among the results of group II, elevated levels of antibodies to adalimumab were found in 12 samples, which was 38 %. The correlation analysis revealed direct statistically significant relationships of moderate strength between the level of antibodies to adalimumab and the indicator of inflammatory activity on JADAS-27 (Spearman’s r = 0.39, p < 0.05), as well as between the level of antibodies and disease duration (Spearman’s r = 0.32, p < 0.05). Conclusions. Monitoring serum antibodies to adalimumab is informative for the correct interpretation of treatment effectiveness and the course of the disease with immunobiological treatment, as it may improve understanding of the clinical consequences of continued therapy, help prevent adalimumab immunogenicity, develop follow-up strategies and, as a result, can affect a long-term outcome of treatment for JIA.
背景。幼年特发性关节炎(JIA)是儿童最常见的风湿病之一。JIA问题的核心是治疗问题，治疗的及时性和充分性决定了疾病的预后，事实上，也决定了孩子的整个未来。免疫生物学治疗可以引起稳定的临床和实验室缓解，并阻止结构变化的进一步进展，影响特发性关节炎的发病环节。但是对治疗缺乏反应或其有效性下降仍然是一个相当普遍的问题，在许多情况下，可能是由免疫生物学药物的免疫原性引起的，特别是在使用肿瘤坏死因子抑制剂治疗的情况下。研究阿达木单抗在幼年特发性关节炎不同治疗阶段的抗体水平，分析其免疫原性。材料和方法。研究评价80例JIA患者血清样品中阿达木单抗抗体浓度，分析56例不同治疗阶段JIA患者的治疗效果及不良事件。确定了两组。第一个包括24名患者，他们因非医学原因至少中断阿达木单抗治疗6个月，在此期间继续使用甲氨蝶呤并定期关节内注射糖皮质激素。阿达木单抗抗体水平在停药前和重新开始阿达木单抗治疗后1个月进行评估。第二组由32名儿童组成，他们在治疗期间不间断地继续使用阿达木单抗。使用JADAS-27测量疾病活动性。采用酶联免疫吸附法检测阿达木单抗抗体。结果。在检查期间，在非药物停药前的24份血清样本中，有10份(42%)检测到阿达木单抗抗体水平升高。在II组的结果中，有12份样本检测到阿达木单抗抗体水平升高，占38%。相关分析显示，阿达木单抗抗体水平与JADAS-27炎症活性指标之间存在中等强度的直接统计学关系(Spearman’s r = 0.39, p < 0.05)，抗体水平与病程之间存在中等强度的直接统计学关系(Spearman’s r = 0.32, p < 0.05)。结论。监测阿达木单抗的血清抗体对于正确解释免疫生物学治疗的治疗效果和病程提供了信息，因为它可以提高对继续治疗的临床后果的理解，有助于预防阿达木单抗的免疫原性，制定随访策略，因此可以影响JIA治疗的长期结果。
{"title":"Levels of antibodies to adalimumab in children with juvenile idiopathic arthritis at different stages of treatment","authors":"T. Marushko, O.Ye. Onufreiv, Y. Marushko, O. German","doi":"10.22141/2224-0551.18.1.2023.1553","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1553","url":null,"abstract":"Background. Juvenile idiopathic arthritis (JIA) is one of the most common rheumatological diseases of childhood. The central place in the problem of JIA belongs to the question of treatment the timeliness and adequacy of which determine the disease prognosis and, in fact, the entire future of the child. Immunobiological therapy can cause stable clinical and laboratory remission, as well as stop the further progression of structural changes, affecting the pathogenetic link of idiopathic arthritis. But the lack of response to therapy or a decrease in its effectiveness remains a fairly common problem and, in many cases, can be caused by the immunogenicity of immunobiological drugs, especially in case of treatment with tumor necrosis factor inhibitors. Aim of the work: to study the level of antibodies to adalimumab in children with juvenile idiopathic arthritis at different stages of treatment for analysis of immunogenicity. Materials and methods. The concentration of antibodies to adalimumab in 80 serum samples from patients with JIA was studied and evaluated, treatment effectiveness and adverse events were analyzed in 56 patients with JIA at different stages of therapy. Two groups were identified. The first one included 24 patients who had at least a 6-month break in adalimumab administration for non-medical reasons during which treatment was continued with methotrexate with periodic intra-articular injection of glucocorticoids. The level of antibodies to adalimumab was evaluated before the break and 1 month after the reinitiation of adalimumab administration. The second group consisted of 32 children who continued adalimumab without a break during treatment. Disease activity was measured using JADAS-27. Antibodies to adalimumab were detected by enzyme-linked immunosorbent assay. Results. During the examination, an elevated level of antibodies to adalimumab was detected in 10 of 24 serum samples (42 %) before non-medical withdrawal in group I. Among the results of group II, elevated levels of antibodies to adalimumab were found in 12 samples, which was 38 %. The correlation analysis revealed direct statistically significant relationships of moderate strength between the level of antibodies to adalimumab and the indicator of inflammatory activity on JADAS-27 (Spearman’s r = 0.39, p < 0.05), as well as between the level of antibodies and disease duration (Spearman’s r = 0.32, p < 0.05). Conclusions. Monitoring serum antibodies to adalimumab is informative for the correct interpretation of treatment effectiveness and the course of the disease with immunobiological treatment, as it may improve understanding of the clinical consequences of continued therapy, help prevent adalimumab immunogenicity, develop follow-up strategies and, as a result, can affect a long-term outcome of treatment for JIA.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116875476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1556
O. Abaturov, A. Tovarnytska
Background. Breast milk (BM) is an optimal nutritional product for newborns and a source of exogenous microRNAs (miR). MiR-148a is one of the most highly expressed miR of BM. Currently, there is a lack of data on the miR-148a effect on the development of necrotizing enterocolitis (NEC) in premature newborns. The purpose of the study was to determine the influence of miR-148a of the mother’s BM on the risk of NEC development in preterm newborns. Materials and methods. We examined 74 newborns, who were treated in neonatal departments. We determined the level of miR-148a in the BM of 44 mothers of exclusively breastfed children. In parallel, we evaluated gene expression of the transcription factor T-bet in scrapings of the buccal mucosa of all the newborns. Three groups for comparison were selected: group 1 consisted of 32 newborns up to 37 weeks of gestation on breastfeeding (BF); group 2 — of 30 preterm newborns on artificial feeding; the control group — 12 full-term newborns on BF. Results. The gestational age median of group 1 children was 33 (31; 34) weeks; group 2 — 32.5 (32; 35) weeks; and it was comparatively higher in the control group (p < 0.001) — 40 (39; 41) weeks. Neonatal encephalopathy as the main diagnosis occurred more often among full-term newborns (p < 0.001). Children of groups 1 and 2 did not differ significantly in the frequency of cases of respiratory distress syndrome and neonatal encephalopathy (p > 0.05). In group 2 compared to the first one, manifestations of NEC occurred significantly more often (p < 0.05): 9/30.0 ± 8.4 % vs 3/9.4 ± 5.2 %. We determined that the level of miR-148a expression in the BM of the mothers of premature children on BF was significantly lower (p < 0.001) than in the group of full-term children: 0.089 (0.048; 0.142) c.u. vs 1.0 (1.0; 1.0) c.u. Furthermore, the level of the transcription factor T-bet expression in the cells of the buccal mucosa scrapings was higher in premature children with clinical NEC (p = 0.022): 2.36 (1.94; 3.17) c.u. vs 1.49 (1.0; 3.27) c.u. in children without signs of NEC. We proved the presence of direct positive correlation between the T-bet level and NEC manifestations (r = 0.271; p = 0.021) and determined the inverse correlation between the level of miR-148a expression in the mother’s BM and the level of T-bet expression (r = –0.371; p = 0.043). Conclusions. The miR-148a expression level is relatively lower in the BM of the mothers whose children were born prematurely and have problems with adaptation than in the mothers who gave birth at term. However, in case of NEC development, there is an increase of miR-148a level in the mother’s BM, which contributes to a decrease in the T-bet expression in the mucous membranes of the child and has a protective impact on intestinal walls.
{"title":"Anti-inflammatory effect of breast milk miR-148a on the state of mucous membranes in premature newborns","authors":"O. Abaturov, A. Tovarnytska","doi":"10.22141/2224-0551.18.1.2023.1556","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1556","url":null,"abstract":"Background. Breast milk (BM) is an optimal nutritional product for newborns and a source of exogenous microRNAs (miR). MiR-148a is one of the most highly expressed miR of BM. Currently, there is a lack of data on the miR-148a effect on the development of necrotizing enterocolitis (NEC) in premature newborns. The purpose of the study was to determine the influence of miR-148a of the mother’s BM on the risk of NEC development in preterm newborns. Materials and methods. We examined 74 newborns, who were treated in neonatal departments. We determined the level of miR-148a in the BM of 44 mothers of exclusively breastfed children. In parallel, we evaluated gene expression of the transcription factor T-bet in scrapings of the buccal mucosa of all the newborns. Three groups for comparison were selected: group 1 consisted of 32 newborns up to 37 weeks of gestation on breastfeeding (BF); group 2 — of 30 preterm newborns on artificial feeding; the control group — 12 full-term newborns on BF. Results. The gestational age median of group 1 children was 33 (31; 34) weeks; group 2 — 32.5 (32; 35) weeks; and it was comparatively higher in the control group (p < 0.001) — 40 (39; 41) weeks. Neonatal encephalopathy as the main diagnosis occurred more often among full-term newborns (p < 0.001). Children of groups 1 and 2 did not differ significantly in the frequency of cases of respiratory distress syndrome and neonatal encephalopathy (p > 0.05). In group 2 compared to the first one, manifestations of NEC occurred significantly more often (p < 0.05): 9/30.0 ± 8.4 % vs 3/9.4 ± 5.2 %. We determined that the level of miR-148a expression in the BM of the mothers of premature children on BF was significantly lower (p < 0.001) than in the group of full-term children: 0.089 (0.048; 0.142) c.u. vs 1.0 (1.0; 1.0) c.u. Furthermore, the level of the transcription factor T-bet expression in the cells of the buccal mucosa scrapings was higher in premature children with clinical NEC (p = 0.022): 2.36 (1.94; 3.17) c.u. vs 1.49 (1.0; 3.27) c.u. in children without signs of NEC. We proved the presence of direct positive correlation between the T-bet level and NEC manifestations (r = 0.271; p = 0.021) and determined the inverse correlation between the level of miR-148a expression in the mother’s BM and the level of T-bet expression (r = –0.371; p = 0.043). Conclusions. The miR-148a expression level is relatively lower in the BM of the mothers whose children were born prematurely and have problems with adaptation than in the mothers who gave birth at term. However, in case of NEC development, there is an increase of miR-148a level in the mother’s BM, which contributes to a decrease in the T-bet expression in the mucous membranes of the child and has a protective impact on intestinal walls.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130128455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1551
Y. Antypkin, V. Lapshyn, T. Umanets, T. Kaminska, N. Banadyha, О. Koloskova, O. Lychkovska, T. Harashchenko, V. Podolskiy, V. Podolskiy
Background. Studying COVID-19 prevalence among children is important for constant monitoring of the epidemiological situation, determination of the most vulnerable categories of children, and planning preventive measures. The aim of our research was a retrospective study of COVID-19 prevalence among children of Ukraine in 2020. Materials and methods. A retrospective study of COVID-19 prevalence among children from different regions of Ukraine was conducted, based on official statistical reports of the Ministry of Health of Ukraine. The prevalence of COVID-19 was measured as the number of cases per 100,000 children. Results. Among the population of Ukraine, children with confirmed SARS-CoV-2 infection amounted to 0.12 %, and among the children’s population of Ukraine — 0.7 %, while the prevalence rate reached 688.64. The incidence of COVID-19 among children in 2020 was highest in Kyiv, Chernivtsi, and Zaporizhzhia regions, and the lowest one was recorded in Kirovohrad, Luhansk, and Donetsk regions. In the age structure of Ukrainian children with SARS-CoV-2 infection, adolescents (63.8 %) prevailed. Conclusions. Adolescents were the age group of children most vulnerable to SARS-CoV-2 in Ukraine. The relatively low COVID-19 prevalence among children in Ukraine may be evidence of underdiagnosis due to insufficient coverage of laboratory testing for SARS-CoV-2 infection in the first year of the pandemic.
{"title":"Analysis of the COVID-19 prevalence among children in Ukraine during the first year of the pandemic","authors":"Y. Antypkin, V. Lapshyn, T. Umanets, T. Kaminska, N. Banadyha, О. Koloskova, O. Lychkovska, T. Harashchenko, V. Podolskiy, V. Podolskiy","doi":"10.22141/2224-0551.18.1.2023.1551","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1551","url":null,"abstract":"Background. Studying COVID-19 prevalence among children is important for constant monitoring of the epidemiological situation, determination of the most vulnerable categories of children, and planning preventive measures. The aim of our research was a retrospective study of COVID-19 prevalence among children of Ukraine in 2020. Materials and methods. A retrospective study of COVID-19 prevalence among children from different regions of Ukraine was conducted, based on official statistical reports of the Ministry of Health of Ukraine. The prevalence of COVID-19 was measured as the number of cases per 100,000 children. Results. Among the population of Ukraine, children with confirmed SARS-CoV-2 infection amounted to 0.12 %, and among the children’s population of Ukraine — 0.7 %, while the prevalence rate reached 688.64. The incidence of COVID-19 among children in 2020 was highest in Kyiv, Chernivtsi, and Zaporizhzhia regions, and the lowest one was recorded in Kirovohrad, Luhansk, and Donetsk regions. In the age structure of Ukrainian children with SARS-CoV-2 infection, adolescents (63.8 %) prevailed. Conclusions. Adolescents were the age group of children most vulnerable to SARS-CoV-2 in Ukraine. The relatively low COVID-19 prevalence among children in Ukraine may be evidence of underdiagnosis due to insufficient coverage of laboratory testing for SARS-CoV-2 infection in the first year of the pandemic.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129300762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1558
O.V. Tymoshyna, L. Ovcharenko, A.O. Vertehel, I.V. Samokhin, O.V. Kryazhev
Актуальність. Після зараження респіраторними вірусами спостерігається підвищена продукція прозапальних цитокінів, включно з фактором некрозу пухлини α (ФНП-α), інтерлейкіном (IL) 6, IL-1β, які призводять до перехресної активації нейроендокринної імунної системи, що здатно погіршувати фагоцитоз з підвищенням захворюваності на гострі респіраторні захворювання (ГРЗ), формуючи порочне коло. Мета дослідження: підвищення ефективності діагностики імунних порушень при частих ГРЗ у дітей віком 2–5 років шляхом порівняльного аналізу даних, отриманих на підставі дослідження деяких параметрів фагоцитозу, сироваткових рівнів прозапальних цитокінів та продуктів перекисного окиснення ліпідів (ПОЛ). Матеріали та методи. Під спостереженням перебували 60 дітей віком від 2 до 5 років, з яких було сформовано 2 групи: 1) діти, які часто хворіють на гострі інфекційні захворювання респіраторного тракту (n = 30); 2) діти, які хворіють на гострі інфекційні захворювання респіраторного тракту менше ніж 6 разів на рік (n = 30). Результати. Серед дітей 1-ї групи була збільшена частота реєстрації низьких показників фагоцитарного числа (на 60,0 %, р < 0,05), фагоцитарного індексу (на 56,0 %, р < 0,05), індексу завершеності фагоцитозу (на 70,0 %, р < 0,05), стимульованого стафілококом НСТ-тесту (на 50,0 %, р < 0,05) та високих показників спонтанного НСТ-тесту (на 43,3 %, р < 0,05), вмісту у сироватці крові інтерлейкіну-1β (на 46,7 %, р < 0,05), інтерлейкіну-6 (на 43,3 %, р < 0,05), інтерлейкіну-10 (на 30,0 %, р < 0,05), ФНП-α (на 46,7 %, р < 0,05); відзначалося збільшення співвідношення інтерлейкіну-6/-10 в 2 та більше рази, високих показників гідроперекисів ліпідів (на 80,0 %, р < 0,05), дієнових кон’югат (на 80,0 %, р < 0,05), малонового діальдегіду (на 76,7 %, р < 0,05), дієнових кетонів (на 76,7 %, р < 0,05), шифових основ (на 76,7 %, р < 0,05). Висновки. Діти віком 2–5 років, які часто хворіють на ГРЗ, мають особливості поглинальної, цитокініндукуючої й метаболічної функцій фагоцитозу, що проявилося у збільшенні сироваткової концентрації прозапальних цитокінів та продуктів усіх стадій перекисного окиснення ліпідів клітинних мембран.
{"title":"Комплексна оцінка деяких параметрів фагоцитозу у дітей віком 2–5 років залежно від частоти захворюваності на гострі респіраторні інфекції","authors":"O.V. Tymoshyna, L. Ovcharenko, A.O. Vertehel, I.V. Samokhin, O.V. Kryazhev","doi":"10.22141/2224-0551.18.1.2023.1558","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1558","url":null,"abstract":"Актуальність. Після зараження респіраторними вірусами спостерігається підвищена продукція прозапальних цитокінів, включно з фактором некрозу пухлини α (ФНП-α), інтерлейкіном (IL) 6, IL-1β, які призводять до перехресної активації нейроендокринної імунної системи, що здатно погіршувати фагоцитоз з підвищенням захворюваності на гострі респіраторні захворювання (ГРЗ), формуючи порочне коло. Мета дослідження: підвищення ефективності діагностики імунних порушень при частих ГРЗ у дітей віком 2–5 років шляхом порівняльного аналізу даних, отриманих на підставі дослідження деяких параметрів фагоцитозу, сироваткових рівнів прозапальних цитокінів та продуктів перекисного окиснення ліпідів (ПОЛ). Матеріали та методи. Під спостереженням перебували 60 дітей віком від 2 до 5 років, з яких було сформовано 2 групи: 1) діти, які часто хворіють на гострі інфекційні захворювання респіраторного тракту (n = 30); 2) діти, які хворіють на гострі інфекційні захворювання респіраторного тракту менше ніж 6 разів на рік (n = 30). Результати. Серед дітей 1-ї групи була збільшена частота реєстрації низьких показників фагоцитарного числа (на 60,0 %, р < 0,05), фагоцитарного індексу (на 56,0 %, р < 0,05), індексу завершеності фагоцитозу (на 70,0 %, р < 0,05), стимульованого стафілококом НСТ-тесту (на 50,0 %, р < 0,05) та високих показників спонтанного НСТ-тесту (на 43,3 %, р < 0,05), вмісту у сироватці крові інтерлейкіну-1β (на 46,7 %, р < 0,05), інтерлейкіну-6 (на 43,3 %, р < 0,05), інтерлейкіну-10 (на 30,0 %, р < 0,05), ФНП-α (на 46,7 %, р < 0,05); відзначалося збільшення співвідношення інтерлейкіну-6/-10 в 2 та більше рази, високих показників гідроперекисів ліпідів (на 80,0 %, р < 0,05), дієнових кон’югат (на 80,0 %, р < 0,05), малонового діальдегіду (на 76,7 %, р < 0,05), дієнових кетонів (на 76,7 %, р < 0,05), шифових основ (на 76,7 %, р < 0,05). Висновки. Діти віком 2–5 років, які часто хворіють на ГРЗ, мають особливості поглинальної, цитокініндукуючої й метаболічної функцій фагоцитозу, що проявилося у збільшенні сироваткової концентрації прозапальних цитокінів та продуктів усіх стадій перекисного окиснення ліпідів клітинних мембран.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123413474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1559
M. Semen, O. Lychkovska
Background. According to the biopsychosocial model of medicine, irritable bowel syndrome (IBS) is a heterogeneous disorder that occurs as a result of the complex interaction of biological, psychoemotional and psychosocial factors. Their combination is individual for each patient. The study aims to evaluate the psychoemotional features (anxiety and somatization) in children with IBS depending on the predominant bowel habit and the trigger factor in the development of the disorder. Materials and methods. We enrolled 55 children aged 6–12 years with a verified diagnosis of IBS, following Rome IV Criteria. The control group included 45 children of the same age and gender. The levels of anxiety and somatization were assessed by the Children’s Manifest Anxiety Scale and the Somatoform Symptom Screening, respectively. Results. Children with IBS had significantly higher level of anxiety (р < 0.0001) and somatization (р < 0.0001) in comparison to the control group. We have not found any significant differences in these parameters according to the predominant bowel habit. However, the analysis based on the nature of the trigger factor in the onset of the disorder revealed remarkably higher levels of anxiety (р = 0.0006) and somatization (р = 0.05) in children with stress-associated IBS. Moreover, a direct correlation between the studied parameters (r = 0.69, p < 0.0001) proves their close connection and a tendency to augment each other. Conclusions. Our study confirms a heterogeneity of IBS in children. As psychoemotional factors play a crucial role in the occurrence of IBS, it is necessary to consider them in the development of personalized care planning.
{"title":"Trait anxiety and somatization levels in children with irritable bowel syndrome","authors":"M. Semen, O. Lychkovska","doi":"10.22141/2224-0551.18.1.2023.1559","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1559","url":null,"abstract":"Background. According to the biopsychosocial model of medicine, irritable bowel syndrome (IBS) is a heterogeneous disorder that occurs as a result of the complex interaction of biological, psychoemotional and psychosocial factors. Their combination is individual for each patient. The study aims to evaluate the psychoemotional features (anxiety and somatization) in children with IBS depending on the predominant bowel habit and the trigger factor in the development of the disorder. Materials and methods. We enrolled 55 children aged 6–12 years with a verified diagnosis of IBS, following Rome IV Criteria. The control group included 45 children of the same age and gender. The levels of anxiety and somatization were assessed by the Children’s Manifest Anxiety Scale and the Somatoform Symptom Screening, respectively. Results. Children with IBS had significantly higher level of anxiety (р < 0.0001) and somatization (р < 0.0001) in comparison to the control group. We have not found any significant differences in these parameters according to the predominant bowel habit. However, the analysis based on the nature of the trigger factor in the onset of the disorder revealed remarkably higher levels of anxiety (р = 0.0006) and somatization (р = 0.05) in children with stress-associated IBS. Moreover, a direct correlation between the studied parameters (r = 0.69, p < 0.0001) proves their close connection and a tendency to augment each other. Conclusions. Our study confirms a heterogeneity of IBS in children. As psychoemotional factors play a crucial role in the occurrence of IBS, it is necessary to consider them in the development of personalized care planning.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129167056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1560
V. Velychko, D.O. Lahoda, G. V. Kornovan, Y. Bazhora
According to recent studies, obesity is associated with genetic variations, iatrogenic conditions, viruses, environmental and behavioral factors. Currently, the treatment of childhood obesity is mainly aimed at limiting energy consumption by changing the child’s lifestyle. Families bear the main social responsibility for raising and educating children. Family sports are an addition to school and play an indispensable role. The object of family sports intervention is not only children, but also parents. In addition, parents’ behavior has a lot of influence on the formation of the views of teenagers. Eating habits and attitudes towards one’s own nutrition are also formed thanks to parental example. This article highlights a clinical example of managing a family with a teenage boy diagnosed with obesity. Diet and physical activity recommendations were given to the patient and his parents. Given that there is already a history of interventions to reduce body mass and the patient did not get the desired result, we suggested to focus on modifying the life of not only the patient, but also the family. Due to a comprehensive approach to lifestyle modification of the whole family, we obtained a positive result, namely: the patient reduced his body weight by 20.5 kg during the year of observation. In addition, a decrease in glycated hemoglobin from 6.0 to 5.48 % was observed, which is a good prognostic criterion for the further possible development of diabetes. The patient himself noted that he had improved relationships in the family and with peers.
{"title":"The role of the family in the treatment of obesity in children. Clinical case","authors":"V. Velychko, D.O. Lahoda, G. V. Kornovan, Y. Bazhora","doi":"10.22141/2224-0551.18.1.2023.1560","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1560","url":null,"abstract":"According to recent studies, obesity is associated with genetic variations, iatrogenic conditions, viruses, environmental and behavioral factors. Currently, the treatment of childhood obesity is mainly aimed at limiting energy consumption by changing the child’s lifestyle. Families bear the main social responsibility for raising and educating children. Family sports are an addition to school and play an indispensable role. The object of family sports intervention is not only children, but also parents. In addition, parents’ behavior has a lot of influence on the formation of the views of teenagers. Eating habits and attitudes towards one’s own nutrition are also formed thanks to parental example. This article highlights a clinical example of managing a family with a teenage boy diagnosed with obesity. Diet and physical activity recommendations were given to the patient and his parents. Given that there is already a history of interventions to reduce body mass and the patient did not get the desired result, we suggested to focus on modifying the life of not only the patient, but also the family. Due to a comprehensive approach to lifestyle modification of the whole family, we obtained a positive result, namely: the patient reduced his body weight by 20.5 kg during the year of observation. In addition, a decrease in glycated hemoglobin from 6.0 to 5.48 % was observed, which is a good prognostic criterion for the further possible development of diabetes. The patient himself noted that he had improved relationships in the family and with peers.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125262069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1555
A. Pushnyk, S.L. Nуankovskyy
Background. Children with psychomotor disorders are vulnerable to nutrient deficiencies, which significantly complicate their rehabilitation. The purpose of our study was to identify the nutrient deficiencies in preschool children with psychomotor disorders by analyzing their diet, revealing the relationship between the detected nutrient deficiencies, the gender of the children and their psychomotor disorders in order to improve the effectiveness of rehabilitation. Materials and methods. The diet of 53 preschool children with psychomotor disorders was analyzed using the Child’s Eating Behavior questionnaire, followed by analysis with the licensed computer program Dietplan7. Statistical processing was conducted using parametric and correlational analysis. Results. Different violations of eating behavior in children with psychomotor disorders were determined. They included, in particular, the refusal to consume a number of healthy foods, while preferring mainly semi-finished products, fast food, smoked products, rich in salt and sugar, spices. The diet of most examined children was unbalanced in terms of the content of basic nutrients, vitamins and minerals: an excess of proteins, fats and calories, numerous combined vitamin and mineral deficiencies were detected. A reliable correlation was found between the daily consumption of nutrients and neurological pathology that was most significant in subgroups of children with mental retardation. Conclusions. In the food diet of many children with psychomotor disorders, there were unhealthy eating patterns typical of the Western diet. Numerous deficiencies in the daily consumption of basic nutrients, including vitamins and minerals, were found in them, which had a probable correlation with neurological disorders. To improve the effectiveness of the rehabilitation of children with psychomotor disorders, a multidisciplinary approach is advisable with the involvement of a nutritionist for personalized correction of the child’s diet.
{"title":"Nutrient support for preschool children with psychomotor disorders","authors":"A. Pushnyk, S.L. Nуankovskyy","doi":"10.22141/2224-0551.18.1.2023.1555","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1555","url":null,"abstract":"Background. Children with psychomotor disorders are vulnerable to nutrient deficiencies, which significantly complicate their rehabilitation. The purpose of our study was to identify the nutrient deficiencies in preschool children with psychomotor disorders by analyzing their diet, revealing the relationship between the detected nutrient deficiencies, the gender of the children and their psychomotor disorders in order to improve the effectiveness of rehabilitation. Materials and methods. The diet of 53 preschool children with psychomotor disorders was analyzed using the Child’s Eating Behavior questionnaire, followed by analysis with the licensed computer program Dietplan7. Statistical processing was conducted using parametric and correlational analysis. Results. Different violations of eating behavior in children with psychomotor disorders were determined. They included, in particular, the refusal to consume a number of healthy foods, while preferring mainly semi-finished products, fast food, smoked products, rich in salt and sugar, spices. The diet of most examined children was unbalanced in terms of the content of basic nutrients, vitamins and minerals: an excess of proteins, fats and calories, numerous combined vitamin and mineral deficiencies were detected. A reliable correlation was found between the daily consumption of nutrients and neurological pathology that was most significant in subgroups of children with mental retardation. Conclusions. In the food diet of many children with psychomotor disorders, there were unhealthy eating patterns typical of the Western diet. Numerous deficiencies in the daily consumption of basic nutrients, including vitamins and minerals, were found in them, which had a probable correlation with neurological disorders. To improve the effectiveness of the rehabilitation of children with psychomotor disorders, a multidisciplinary approach is advisable with the involvement of a nutritionist for personalized correction of the child’s diet.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130529086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1554
O. Mozyrska
Background. Atopic dermatitis is a chronic, relapsing eczema. Although atopic dermatitis occurs mainly in children, it greatly affects the life of the whole family. The purpose was to assess the quality of life of the families of children with atopic dermatitis and to study the correlation between the severity of atopic dermatitis and the quality of life of family members according to the Family Dermatology Life Quality Index (FDLQI) questionnaire. Materials and methods. The study included 104 patients with atopic dermatitis aged 6 months to 17 years (median of 6 [3; 9] years) who were treated at the Allergy Department of the Kyiv City Children’s Clinical Hospital 2. Clinical parameters included age, sex of the patients, disease duration and severity of atopic dermatitis. The latter was assessed by the SCORing for Atopic Dermatitis (SCORAD) tool. Spearman’s rank correlation index was used for analysis of correlation between FDLQI and SCORAD indicators. Р < 0.05 was considered statistically significant. Results. The quality of life of the family of 104 children with atopic dermatitis was assessed using the FDLQI questionnaire. Four parents (3.8 %) reported no impact of the disease on the family’s quality of life, 65 (62.5 %) — a mild effect, 34 (32.7 %) — a moderate impact, parents of 1 patient (1.0 %) noted a very large effect. The average FDLQI was 6.4 ± 2.8. There was a correlation between the FDLQI and the SCORAD severity index (Ro = 0.714, p < 0.01). In the subgroup of children under 4 years of age, a strong correlation between the FDLQI and the SCORAD was found (Ro = 0.789, p < 0.01). Child’s age and disease duration were not associated with the quality of life score (Ro = –0.011, p > 0.05 and Ro = 0.076, p > 0.05, respectively). In the subgroup of children aged 4–17 years, a strong positive correlation of FDLQI and the SCORAD was also determined (Ro = 0.714, p < 0.01). The age of the children and the duration of the disease were not related to the quality of life score (Ro = –0.011, p > 0.05 and Ro = –0.027, p > 0.05, respectively), although in the subgroup of younger children (4–7 years) we noted a tendency towards a greater influence of the disease on the family’s quality of life. Conclusion. In this study, most parents of children with atopic dermatitis reported a mild to moderate impact of the disease on their quality of life. The FDLQI of family members correlated with the severity of atopic dermatitis.
背景。特应性皮炎是一种慢性、反复发作的湿疹。特应性皮炎虽然主要发生在儿童身上，但它极大地影响了整个家庭的生活。目的通过家庭皮肤病生活质量指数(FDLQI)问卷，评估特应性皮炎患儿家庭的生活质量，研究特应性皮炎严重程度与家庭成员生活质量的相关性。材料和方法。该研究纳入104例特应性皮炎患者，年龄6个月至17岁(中位数为6;他们在基辅市儿童临床医院过敏科接受治疗。临床参数包括患者的年龄、性别、病程和特应性皮炎的严重程度。后者通过特应性皮炎评分(SCORAD)工具进行评估。采用Spearman等级相关指数分析FDLQI与SCORAD指标的相关性。Р < 0.05认为有统计学意义。结果。采用FDLQI问卷对104例特应性皮炎患儿家庭生活质量进行评估。4名家长(3.8%)报告疾病对家庭生活质量没有影响，65名家长(62.5%)报告影响轻微，34名家长(32.7%)报告影响中度，1名家长(1.0%)报告影响非常大。FDLQI平均值为6.4±2.8。FDLQI与SCORAD严重程度指数存在相关性(Ro = 0.714, p < 0.01)。在4岁以下儿童亚组中，FDLQI与SCORAD有较强的相关性(Ro = 0.789, p < 0.01)。患儿年龄、病程与生活质量评分无相关性(Ro = -0.011, p > 0.05; Ro = 0.076, p > 0.05)。在4 ~ 17岁儿童亚组中，FDLQI与SCORAD也存在较强的正相关(Ro = 0.714, p < 0.01)。儿童的年龄和疾病持续时间与生活质量评分无关(分别为Ro = -0.011, p > 0.05和Ro = -0.027, p > 0.05)，尽管在年龄较小的儿童(4-7岁)亚组中，我们注意到疾病对家庭生活质量的影响有更大的趋势。结论。在这项研究中，大多数患有特应性皮炎儿童的父母报告说，这种疾病对他们的生活质量有轻微到中度的影响。家庭成员FDLQI与特应性皮炎的严重程度相关。
{"title":"Study of the impact of atopic dermatitis in children on the quality of life of families","authors":"O. Mozyrska","doi":"10.22141/2224-0551.18.1.2023.1554","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1554","url":null,"abstract":"Background. Atopic dermatitis is a chronic, relapsing eczema. Although atopic dermatitis occurs mainly in children, it greatly affects the life of the whole family. The purpose was to assess the quality of life of the families of children with atopic dermatitis and to study the correlation between the severity of atopic dermatitis and the quality of life of family members according to the Family Dermatology Life Quality Index (FDLQI) questionnaire. Materials and methods. The study included 104 patients with atopic dermatitis aged 6 months to 17 years (median of 6 [3; 9] years) who were treated at the Allergy Department of the Kyiv City Children’s Clinical Hospital 2. Clinical parameters included age, sex of the patients, disease duration and severity of atopic dermatitis. The latter was assessed by the SCORing for Atopic Dermatitis (SCORAD) tool. Spearman’s rank correlation index was used for analysis of correlation between FDLQI and SCORAD indicators. Р < 0.05 was considered statistically significant. Results. The quality of life of the family of 104 children with atopic dermatitis was assessed using the FDLQI questionnaire. Four parents (3.8 %) reported no impact of the disease on the family’s quality of life, 65 (62.5 %) — a mild effect, 34 (32.7 %) — a moderate impact, parents of 1 patient (1.0 %) noted a very large effect. The average FDLQI was 6.4 ± 2.8. There was a correlation between the FDLQI and the SCORAD severity index (Ro = 0.714, p < 0.01). In the subgroup of children under 4 years of age, a strong correlation between the FDLQI and the SCORAD was found (Ro = 0.789, p < 0.01). Child’s age and disease duration were not associated with the quality of life score (Ro = –0.011, p > 0.05 and Ro = 0.076, p > 0.05, respectively). In the subgroup of children aged 4–17 years, a strong positive correlation of FDLQI and the SCORAD was also determined (Ro = 0.714, p < 0.01). The age of the children and the duration of the disease were not related to the quality of life score (Ro = –0.011, p > 0.05 and Ro = –0.027, p > 0.05, respectively), although in the subgroup of younger children (4–7 years) we noted a tendency towards a greater influence of the disease on the family’s quality of life. Conclusion. In this study, most parents of children with atopic dermatitis reported a mild to moderate impact of the disease on their quality of life. The FDLQI of family members correlated with the severity of atopic dermatitis.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132314755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.22141/2224-0551.18.1.2023.1557
T. Kovalchuk, O. Boyarchuk
Background. There are extremely limited research on the quality of life in children with non-traumatic and non-syncopal transient loss of consciousness (TLOC), which does not sufficiently reflect the impact of epilepsy, first unprovoked epileptic seizure or psychogenic TLOC on the parental quality of life and family functioning. The purpose was to provide a comparative analysis of quality of life in children with non-traumatic and non-syncopal TLOC, as well as to study the impact of these diseases on the family quality of life. Materials and methods. Twenty-two patients with epilepsy, 18 with first unprovoked epileptic seizure, and 18 with psychogenic TLOC aged 8–17 years were examined. The control group consisted of 40 apparently healthy children. Quality of life in children and their parents was assessed using the PedsQL™ 4.0 Generic Core Scales (child report, adolescent report, parent report), and the PedsQL™ 2.0 Family Impact Module (parent report). Results. Epilepsy and psychogenic TLOC have a negative impact on the quality of life of children. Epilepsy was accompanied by deterioration of physical (57.1 ± 5.2; 77.3 ± 4.8 points) and psychosocial health (60.7 ± 5.7; 76.3 ± 2.7 points), while psychogenic TLOC were characterized by only low physical health (55.0 ± 5.5; 77.3 ± 4.8 points) according to patient self-reports (p < 0.01). The quality of life of children with epilepsy was influenced by age (r = –0.55; r = 0.007) and features of clinical manifestation of the epileptic seizure (r = –0.56; r = 0.007). The number of previous non-epileptic seizures had an impact on quality of life among patients with psychogenic TLOC (r = –0.60; r = 0.0008). The first unprovoked epileptic seizure was not accompanied by quality of life deterioration among children and parents. Only epilepsy was associated with a decrease in the quality of life of parents and family as a whole, mainly due to an increased anxiety (38.8 ± 4.5; 63.2 ± 4.0 points), a decrease in emotional functioning (47.5 ± 3.9; 66.9 ± 3.3 points), a lack of effective communication between family members (50.0 ± 4.8; 79.4 ± 2.9 points); p < 0.01. Conclusions. The combined evaluation of quality of life in children and their parents helps better understand the impact of disease course peculiarities and treatment on the child’s and his family’s quality of life in order to provide timely medical and psychological assistance.
{"title":"Quality of life indicators in children with non-traumatic and non-syncopal transient loss of consciousness and their families","authors":"T. Kovalchuk, O. Boyarchuk","doi":"10.22141/2224-0551.18.1.2023.1557","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1557","url":null,"abstract":"Background. There are extremely limited research on the quality of life in children with non-traumatic and non-syncopal transient loss of consciousness (TLOC), which does not sufficiently reflect the impact of epilepsy, first unprovoked epileptic seizure or psychogenic TLOC on the parental quality of life and family functioning. The purpose was to provide a comparative analysis of quality of life in children with non-traumatic and non-syncopal TLOC, as well as to study the impact of these diseases on the family quality of life. Materials and methods. Twenty-two patients with epilepsy, 18 with first unprovoked epileptic seizure, and 18 with psychogenic TLOC aged 8–17 years were examined. The control group consisted of 40 apparently healthy children. Quality of life in children and their parents was assessed using the PedsQL™ 4.0 Generic Core Scales (child report, adolescent report, parent report), and the PedsQL™ 2.0 Family Impact Module (parent report). Results. Epilepsy and psychogenic TLOC have a negative impact on the quality of life of children. Epilepsy was accompanied by deterioration of physical (57.1 ± 5.2; 77.3 ± 4.8 points) and psychosocial health (60.7 ± 5.7; 76.3 ± 2.7 points), while psychogenic TLOC were characterized by only low physical health (55.0 ± 5.5; 77.3 ± 4.8 points) according to patient self-reports (p < 0.01). The quality of life of children with epilepsy was influenced by age (r = –0.55; r = 0.007) and features of clinical manifestation of the epileptic seizure (r = –0.56; r = 0.007). The number of previous non-epileptic seizures had an impact on quality of life among patients with psychogenic TLOC (r = –0.60; r = 0.0008). The first unprovoked epileptic seizure was not accompanied by quality of life deterioration among children and parents. Only epilepsy was associated with a decrease in the quality of life of parents and family as a whole, mainly due to an increased anxiety (38.8 ± 4.5; 63.2 ± 4.0 points), a decrease in emotional functioning (47.5 ± 3.9; 66.9 ± 3.3 points), a lack of effective communication between family members (50.0 ± 4.8; 79.4 ± 2.9 points); p < 0.01. Conclusions. The combined evaluation of quality of life in children and their parents helps better understand the impact of disease course peculiarities and treatment on the child’s and his family’s quality of life in order to provide timely medical and psychological assistance.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115679399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-10DOI: 10.22141/2224-0551.17.8.2022.1544
H. O. Lezhenko, O. Abaturov, N. A. Zakharchenko
Background. The aim of the research was to study the content of 1,25(OH)2D3 and vitamin D-binding protein (DBP) in the blood serum of children with urinary tract infections, taking into account the clinical form of the disease, and to determine their pathogenetic role in the development of urinary tract infections. Materials and methods. The study groups consisted of 84 children (mean age — 10.0 ± 1.3 years). The main group was divided into subgroups: the first one — 17 children with acute pyelonephritis, the second one — 21 patients with chronic pyelonephritis, the third one — 16 children with acute cystitis, the fourth one — 10 patients with unspecified urinary tract infections. The control group consisted of 20 relatively healthy children. The content of 1,25(OH)2D3 and DBP was investigated by immunoenzymatic analysis. Results. It was found that the development of the inflammatory process in the urinary tract was accompanied by a statistically significant (p < 0.01) decrease in the level of 1,25(OH)2D3 in the blood serum of the children of the main group compared to the controls. The level of 1,25(OH)2D3 in patients of all subgroups was significantly lower than that of the control group (p < 0.01), but there was no statistical difference between them. Serum level of DBP in the main group was statistically significantly (p < 0.05) increased compared to the controls, but we did not find a statistically significant difference between the subgroups studied. Conclusions. The development of an acute inflammatory process in the urinary tract in children occurs against the background of a statistically significant decrease in the blood level of 1,25(OH)2D3 combined with high levels of vitamin D-binding protein. This serves as a pathogenetic basis for the need to develop therapeutic and prophylactic schemes for prescribing vitamin D to children with urinary tract infections.
{"title":"The pathogenetic role of vitamin D and vitamin D-binding protein in the development of urinary tract infection in children","authors":"H. O. Lezhenko, O. Abaturov, N. A. Zakharchenko","doi":"10.22141/2224-0551.17.8.2022.1544","DOIUrl":"https://doi.org/10.22141/2224-0551.17.8.2022.1544","url":null,"abstract":"Background. The aim of the research was to study the content of 1,25(OH)2D3 and vitamin D-binding protein (DBP) in the blood serum of children with urinary tract infections, taking into account the clinical form of the disease, and to determine their pathogenetic role in the development of urinary tract infections. Materials and methods. The study groups consisted of 84 children (mean age — 10.0 ± 1.3 years). The main group was divided into subgroups: the first one — 17 children with acute pyelonephritis, the second one — 21 patients with chronic pyelonephritis, the third one — 16 children with acute cystitis, the fourth one — 10 patients with unspecified urinary tract infections. The control group consisted of 20 relatively healthy children. The content of 1,25(OH)2D3 and DBP was investigated by immunoenzymatic analysis. Results. It was found that the development of the inflammatory process in the urinary tract was accompanied by a statistically significant (p < 0.01) decrease in the level of 1,25(OH)2D3 in the blood serum of the children of the main group compared to the controls. The level of 1,25(OH)2D3 in patients of all subgroups was significantly lower than that of the control group (p < 0.01), but there was no statistical difference between them. Serum level of DBP in the main group was statistically significantly (p < 0.05) increased compared to the controls, but we did not find a statistically significant difference between the subgroups studied. Conclusions. The development of an acute inflammatory process in the urinary tract in children occurs against the background of a statistically significant decrease in the blood level of 1,25(OH)2D3 combined with high levels of vitamin D-binding protein. This serves as a pathogenetic basis for the need to develop therapeutic and prophylactic schemes for prescribing vitamin D to children with urinary tract infections.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133442396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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