Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1702
Y. Antypkin, A. Abaturov, N. Medvedovska, L. Denysiuk, O. Miroshnikov, N. Bondarenko
Background. The relevance of the study is due to the importance of maintaining full vision functions from childhood, which allows for having healthy visual perception for a quality life, learning and work capacity in adolescence and adulthood. The problem is gaining global importance, because according to the forecasts of international experts, the spread of ophthalmic pathology in 2050 will reach such a scale that almost a third of the planet’s population will have impaired vision, with most of cases diagnosed already in childhood. Scientific studies reveal an increase in the frequency of visual impairment among school-aged children. Thus, 8–10 % of the first-graders are diagnosed with ophthalmic pathology, and upon completion of schooling, this indicator can increase to 30–50 %. The purpose was to study the awareness of teachers and lecturers of secondary educational institutions (schools, lyceums) regarding the problems of visual impairment among schoolchildren, their attitude to the problem and willingness to participate in preventive measures. Materials and methods. The materials for the research were the results of a sociological survey of educators of secondary educational institutions from all regions of Ukraine (lecturers, teachers at schools and lyceums), a total of 6,215 questionnaires were subject to analysis. The tool for conducting sociological research was the developed Questionnaire of secondary school educators regarding their awareness and willingness to participate in preventive programs to preserve eyesight from childhood. The procedure for filling out the questionnaire included an interview with an interviewer, who verbally informed about the purpose, tasks of sociological research, and its anonymity. Only after obtaining preliminary voluntary verbal consent to participate in the study, respondents were offered to proceed to filling out the questionnaire, which took an average of 15–20 minutes. The research methods were sociological survey, analytical-synthetic, medical-statistical methods, in particular the latter was used to calculate the representativeness and reliability of the survey results. Results. The results of the study prove the importance of the participation of secondary school educators in measures to prevent impairment of visual functions in school-aged children. Despite the high readiness of lecturers and secondary school teachers to engage in preventive activities, their awareness of preventing visual impairment among schoolchildren was found to be insufficient, as was the level of preventive work of medical personnel in schools. It was found that most educators are convinced that a school education worker should be aware of the signs of visual impairment in children (90.46 ± 0.37 %), participate in preventive measures and be familiar with the hygienic norms of visual stress in children (86.39 ± 0.43 %). Most respondents expressed the feasibility of introducing regular systematic supervision of vision func
{"title":"Prevention of vision disorders at school age: view of secondary school teachers on the problem","authors":"Y. Antypkin, A. Abaturov, N. Medvedovska, L. Denysiuk, O. Miroshnikov, N. Bondarenko","doi":"10.22141/2224-0551.19.4.2024.1702","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1702","url":null,"abstract":"Background. The relevance of the study is due to the importance of maintaining full vision functions from childhood, which allows for having healthy visual perception for a quality life, learning and work capacity in adolescence and adulthood. The problem is gaining global importance, because according to the forecasts of international experts, the spread of ophthalmic pathology in 2050 will reach such a scale that almost a third of the planet’s population will have impaired vision, with most of cases diagnosed already in childhood. Scientific studies reveal an increase in the frequency of visual impairment among school-aged children. Thus, 8–10 % of the first-graders are diagnosed with ophthalmic pathology, and upon completion of schooling, this indicator can increase to 30–50 %. The purpose was to study the awareness of teachers and lecturers of secondary educational institutions (schools, lyceums) regarding the problems of visual impairment among schoolchildren, their attitude to the problem and willingness to participate in preventive measures. Materials and methods. The materials for the research were the results of a sociological survey of educators of secondary educational institutions from all regions of Ukraine (lecturers, teachers at schools and lyceums), a total of 6,215 questionnaires were subject to analysis. The tool for conducting sociological research was the developed Questionnaire of secondary school educators regarding their awareness and willingness to participate in preventive programs to preserve eyesight from childhood. The procedure for filling out the questionnaire included an interview with an interviewer, who verbally informed about the purpose, tasks of sociological research, and its anonymity. Only after obtaining preliminary voluntary verbal consent to participate in the study, respondents were offered to proceed to filling out the questionnaire, which took an average of 15–20 minutes. The research methods were sociological survey, analytical-synthetic, medical-statistical methods, in particular the latter was used to calculate the representativeness and reliability of the survey results. Results. The results of the study prove the importance of the participation of secondary school educators in measures to prevent impairment of visual functions in school-aged children. Despite the high readiness of lecturers and secondary school teachers to engage in preventive activities, their awareness of preventing visual impairment among schoolchildren was found to be insufficient, as was the level of preventive work of medical personnel in schools. It was found that most educators are convinced that a school education worker should be aware of the signs of visual impairment in children (90.46 ± 0.37 %), participate in preventive measures and be familiar with the hygienic norms of visual stress in children (86.39 ± 0.43 %). Most respondents expressed the feasibility of introducing regular systematic supervision of vision func","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"21 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1703
H.V. Beketova, Y. Klymova
Background. Bone tissue is actively exposed to environmental factors and lifestyle. Since the bone mass accumulated in childhood will determine the state of the skeleton during a person’s subsequent life, it is necessary to promote its maximum increase. Sufficient nutrition is one of the main factors in maintaining bone health. The purpose of our study was to determine the level of daily basic nutrient intake among schoolchildren and to reveal its relationship with clinical disorders of the musculoskeletal system. Materials and methods. Using a computer program, we assessed the actual diet of 65 schoolchildren aged from 8 to 17 years. Results. It was found that 90 % of children were deficient in iodine and calcium, and more than 70 % were deficient in zinc and selenium. The deficiency of potassium, magnesium, iron, copper, fluorine, manganese, and phosphorus was less pronounced. A significant deficiency of vitamin D, β-carotene, vitamin A, biotin, and vitamin E was noted. In almost half of the examined children, the share of saturated fatty acids in the diet exceeds the recommended norm, while the level of polyunsaturated fatty acids is significantly reduced. In 93.8 % of schoolchildren, the nutritional ratio between calcium and phosphorus is disturbed. Conclusions. The obtained results testify to the unbalanced diet of schoolchildren and inconsistency with physiological needs. Deficiency of a number of nutrients can contribute to musculoskeletal pain, convulsive syndrome, fractures, caries and recurrent respiratory disease.
{"title":"Nutrition to support a healthy skeleton","authors":"H.V. Beketova, Y. Klymova","doi":"10.22141/2224-0551.19.4.2024.1703","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1703","url":null,"abstract":"Background. Bone tissue is actively exposed to environmental factors and lifestyle. Since the bone mass accumulated in childhood will determine the state of the skeleton during a person’s subsequent life, it is necessary to promote its maximum increase. Sufficient nutrition is one of the main factors in maintaining bone health. The purpose of our study was to determine the level of daily basic nutrient intake among schoolchildren and to reveal its relationship with clinical disorders of the musculoskeletal system. Materials and methods. Using a computer program, we assessed the actual diet of 65 schoolchildren aged from 8 to 17 years. Results. It was found that 90 % of children were deficient in iodine and calcium, and more than 70 % were deficient in zinc and selenium. The deficiency of potassium, magnesium, iron, copper, fluorine, manganese, and phosphorus was less pronounced. A significant deficiency of vitamin D, β-carotene, vitamin A, biotin, and vitamin E was noted. In almost half of the examined children, the share of saturated fatty acids in the diet exceeds the recommended norm, while the level of polyunsaturated fatty acids is significantly reduced. In 93.8 % of schoolchildren, the nutritional ratio between calcium and phosphorus is disturbed. Conclusions. The obtained results testify to the unbalanced diet of schoolchildren and inconsistency with physiological needs. Deficiency of a number of nutrients can contribute to musculoskeletal pain, convulsive syndrome, fractures, caries and recurrent respiratory disease.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1707
N.V. Gryshchenko, O. Kovalchuk
Background. Monitoring the level of satisfaction of undergraduates on the specialty 222 “Medicine” concerning their training in pediatrics and the level of mastering the necessary competencies is an important marker that allows timely assessment of the quality of the educational services provision, as well as the improvement and expansion of their range in relation to the students’ needs. Objective: to analyze the satisfaction level of the students’ training in pediatrics and to determine ways of improving the teaching of pediatric disciplines to the 6th year foreign students on the specialty 222 “Medicine” at the Department of Pediatrics 2 of the Bogomolets National Medical University based on the anonymous survey results. Materials and methods. The survey was conducted using 4–5-point Likert scale questionnaire in Google Form. Results. Practically all students were basically satisfied with the knowledge obtained in pediatric disciplines they studied at the Department of Pediatrics 2 from the 2nd to the 6th years, with a special emphasis on preparation during the graduation year. Only one third (34.7 %) of respondents in general noted that the organization and delivery of an online training did not deteriorate the quality of knowledge and practical skills in pediatrics. The respondents were particularly interested in sections of pediatrics such as cardiology, rheumatology, pulmonology and neonatology. The insufficient satisfaction of higher education seekers with level of their knowledge in propaedeutics of pediatrics, pathology of young children and pediatric cardiology requires a corresponding correction of the curriculum — an increase in the number of academic hours in these sections of pediatrics and more effective use of the self-directed independent learning. Conclusions. Monitoring the satisfaction level is an effective method of communication with medical undergraduates aimed at identifying problems and improving the effectiveness of training and educational process for foreign students, who in general positively evaluated the results of their five-year study of pediatric disciplines at the Department of Pediatrics 2 of the Bogomolets National Medical University.
{"title":"Monitoring the level of satisfaction with the quality of training in pediatrics of undergraduates on the specialty 222 “Medicine” of the Faculty for Training of Foreign Citizens of the Bogomolets National Medical University","authors":"N.V. Gryshchenko, O. Kovalchuk","doi":"10.22141/2224-0551.19.4.2024.1707","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1707","url":null,"abstract":"Background. Monitoring the level of satisfaction of undergraduates on the specialty 222 “Medicine” concerning their training in pediatrics and the level of mastering the necessary competencies is an important marker that allows timely assessment of the quality of the educational services provision, as well as the improvement and expansion of their range in relation to the students’ needs. Objective: to analyze the satisfaction level of the students’ training in pediatrics and to determine ways of improving the teaching of pediatric disciplines to the 6th year foreign students on the specialty 222 “Medicine” at the Department of Pediatrics 2 of the Bogomolets National Medical University based on the anonymous survey results. Materials and methods. The survey was conducted using 4–5-point Likert scale questionnaire in Google Form. Results. Practically all students were basically satisfied with the knowledge obtained in pediatric disciplines they studied at the Department of Pediatrics 2 from the 2nd to the 6th years, with a special emphasis on preparation during the graduation year. Only one third (34.7 %) of respondents in general noted that the organization and delivery of an online training did not deteriorate the quality of knowledge and practical skills in pediatrics. The respondents were particularly interested in sections of pediatrics such as cardiology, rheumatology, pulmonology and neonatology. The insufficient satisfaction of higher education seekers with level of their knowledge in propaedeutics of pediatrics, pathology of young children and pediatric cardiology requires a corresponding correction of the curriculum — an increase in the number of academic hours in these sections of pediatrics and more effective use of the self-directed independent learning. Conclusions. Monitoring the satisfaction level is an effective method of communication with medical undergraduates aimed at identifying problems and improving the effectiveness of training and educational process for foreign students, who in general positively evaluated the results of their five-year study of pediatric disciplines at the Department of Pediatrics 2 of the Bogomolets National Medical University.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1704
M.L. Aryayev, L. Senkivska, Y.D. Senkivska
Background. The significance of this study lies in the fact that short stature is highly prevalent among children, affecting 1–5 % of the population and having diverse causes. The child’s growth potential in the long term is largely depends on the effectiveness of the diagnostic system and the level of adherence to the prescribed therapy. The purpose was to improve the diagnosis of growth hormone deficiency (GHD) in children and adherence to recombinant human growth hormone (rhGH) therapy based on information about the regional prevalence of the disease and barriers to adherence. Materials and methods. A follow-up study was conducted from 2012 to 2020 at the Odesa Regional Children’s Hospital. The cohort included 94 children with GHD. The prevalence was determined by calculating the ratio of the number of all detected GHD cases to the children population per 100,000. Adherence was measured using the Morisky Medication Adherence Scale. The statistical processing of the results was done using t-test and chi-square methods, and p-values less than 0.05 were considered statistically significant. Results. An assessment of GHD prevalence, the level of adherence and the frequency of continuity of rhGH therapy in children in the Odesa region at the end of 2014 revealed the incompleteness of regional diagnosis of the disease (in Odesa, 1 : 11,200; in the Odesa region, 1 : 10,800), as well as a low level of acceptable adherence (in 57.4 %) and insufficient frequency of continuity of therapy (in 76.9 %). These data formed the basis of the regional program for optimizing the identification and management of GHD in children, which included organizational, medical and social measures. By the end of 2020, the prevalence of GHD in Odesa was 1 : 4,300, and in the Odesa region, 1 : 5,100. The rate of acceptable adherence to rhGH therapy increased to 80.0 %, and frequency of continuity of therapy to 91.1 %. Conclusions. The regional program designed to improve the detection and management of GHD in children has been found to improve the diagnosis of the disease, increase adherence to rhGH therapy, and the frequency of continuity of treatment. High adherence to treatment is a bioethical issue because it signifies a good partnership between physicians, children, and parents and indicates respect for patient autonomy.
{"title":"Program to optimise detecting growth hormone deficiency in children and increase adherence to replacement therapy","authors":"M.L. Aryayev, L. Senkivska, Y.D. Senkivska","doi":"10.22141/2224-0551.19.4.2024.1704","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1704","url":null,"abstract":"Background. The significance of this study lies in the fact that short stature is highly prevalent among children, affecting 1–5 % of the population and having diverse causes. The child’s growth potential in the long term is largely depends on the effectiveness of the diagnostic system and the level of adherence to the prescribed therapy. The purpose was to improve the diagnosis of growth hormone deficiency (GHD) in children and adherence to recombinant human growth hormone (rhGH) therapy based on information about the regional prevalence of the disease and barriers to adherence. Materials and methods. A follow-up study was conducted from 2012 to 2020 at the Odesa Regional Children’s Hospital. The cohort included 94 children with GHD. The prevalence was determined by calculating the ratio of the number of all detected GHD cases to the children population per 100,000. Adherence was measured using the Morisky Medication Adherence Scale. The statistical processing of the results was done using t-test and chi-square methods, and p-values less than 0.05 were considered statistically significant. Results. An assessment of GHD prevalence, the level of adherence and the frequency of continuity of rhGH therapy in children in the Odesa region at the end of 2014 revealed the incompleteness of regional diagnosis of the disease (in Odesa, 1 : 11,200; in the Odesa region, 1 : 10,800), as well as a low level of acceptable adherence (in 57.4 %) and insufficient frequency of continuity of therapy (in 76.9 %). These data formed the basis of the regional program for optimizing the identification and management of GHD in children, which included organizational, medical and social measures. By the end of 2020, the prevalence of GHD in Odesa was 1 : 4,300, and in the Odesa region, 1 : 5,100. The rate of acceptable adherence to rhGH therapy increased to 80.0 %, and frequency of continuity of therapy to 91.1 %. Conclusions. The regional program designed to improve the detection and management of GHD in children has been found to improve the diagnosis of the disease, increase adherence to rhGH therapy, and the frequency of continuity of treatment. High adherence to treatment is a bioethical issue because it signifies a good partnership between physicians, children, and parents and indicates respect for patient autonomy.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"9 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1709
N.A. Sliusar, O. Volosovets, S. Kryvopustov, S. Saltanova
Background. The medico-social significance of functional gastrointestinal disorders (FGID) in children is due to their prevalence and impact on the quality of life of patients. According to the biopsychosocial model, FGID are heterogeneous diseases that arise as a result of a complex interaction of biological, psychoemotional, and psychosocial factors. Objective: based on the generalization of available literature data, to highlight the influence of serotonin and melatonin neurotransmitters on the course of FGIR associated with emotional volitional disturbances caused by stress in children. Materials and methods. Modern domestic and international scientific literature on the influence of serotonin and melatonin on the course of FGIR associated with emotional volitional disturbances caused by stress in children was reviewed and analyzed. To search for literary sources, the Scopus, PubMed, ResearchGate, Wiley Online Library, and Google Scholar databases were studied for 2016–2024, a total of 98 sources. Results. Modern etiopathogenetic factors for the occurrence of FGIR in children are described, with the key components of their biopsychosocial model highlighted. The influence of stressors on the development of mental disorders in children with FGIR, in particular emotional and volitional changes, is considered. We have demonstrated the role of serotonin and melatonin in the regulation of mood, emotions, sleep, behavior, anxiety, depression, etc. The importance of these neurotransmitters in the occurrence of gastrointestinal symptoms in FGIR is highlighted with modern approaches to the management of children with FGIR associated with emotional volitional disturbances caused by stress being considered. A promising therapeutic direction is identified — the use of supplements of certain neurotransmitters (in particular, serotonin and melatonin) in children with this pathology. Conclusions. The analyzed literature data demonstrate the heterogeneity of FGIR in children and the importance of stressors in their development. Neurotransmitters play a significant role in the formation of the response to stress and the course of FGIR associated with emotional volitional disturbances caused by stress in children. Data on the effectiveness of serotonin and melatonin supplementation in children with FGIR are few, so there is a need for further research on this issue in order to improve the effectiveness of treatment and the quality of life of these patients.
{"title":"The effect of neurotransmitters on the course of functional gastrointestinal disorders associated with emotional volitional disturbances caused by stress in children","authors":"N.A. Sliusar, O. Volosovets, S. Kryvopustov, S. Saltanova","doi":"10.22141/2224-0551.19.4.2024.1709","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1709","url":null,"abstract":"Background. The medico-social significance of functional gastrointestinal disorders (FGID) in children is due to their prevalence and impact on the quality of life of patients. According to the biopsychosocial model, FGID are heterogeneous diseases that arise as a result of a complex interaction of biological, psychoemotional, and psychosocial factors. Objective: based on the generalization of available literature data, to highlight the influence of serotonin and melatonin neurotransmitters on the course of FGIR associated with emotional volitional disturbances caused by stress in children. Materials and methods. Modern domestic and international scientific literature on the influence of serotonin and melatonin on the course of FGIR associated with emotional volitional disturbances caused by stress in children was reviewed and analyzed. To search for literary sources, the Scopus, PubMed, ResearchGate, Wiley Online Library, and Google Scholar databases were studied for 2016–2024, a total of 98 sources. Results. Modern etiopathogenetic factors for the occurrence of FGIR in children are described, with the key components of their biopsychosocial model highlighted. The influence of stressors on the development of mental disorders in children with FGIR, in particular emotional and volitional changes, is considered. We have demonstrated the role of serotonin and melatonin in the regulation of mood, emotions, sleep, behavior, anxiety, depression, etc. The importance of these neurotransmitters in the occurrence of gastrointestinal symptoms in FGIR is highlighted with modern approaches to the management of children with FGIR associated with emotional volitional disturbances caused by stress being considered. A promising therapeutic direction is identified — the use of supplements of certain neurotransmitters (in particular, serotonin and melatonin) in children with this pathology. Conclusions. The analyzed literature data demonstrate the heterogeneity of FGIR in children and the importance of stressors in their development. Neurotransmitters play a significant role in the formation of the response to stress and the course of FGIR associated with emotional volitional disturbances caused by stress in children. Data on the effectiveness of serotonin and melatonin supplementation in children with FGIR are few, so there is a need for further research on this issue in order to improve the effectiveness of treatment and the quality of life of these patients.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"6 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1711
S.O. Mokia-Serbina, V.I. Fesenko
Scientific research in recent years has increased the interest of clinicians in the role of microorganisms in maintaining health and the occurrence of diseases. In most cases, fungal lesions of the oral mucosa are a manifestation of numerous somatic diseases and the results of their treatment and contribute to complications. To write this article, the information was searched using the databases Scopus, Web of Science, Med Zine, Pub Med, Google Scholar, the new version of the International Classification of Diseases (ICD-11) and the Standards of Care “Rational use of antibacterial and antifungal drugs for therapeutic and prophylactic purposes” (2023) were taken into account. The review presents data from the world literature on the role of fungal infection in the development of oropharyngeal candidiasis in children, current perspectives on the mechanism of its formation, clinical manifestations and diagnosis. A comparative characterization of the recommendations of national and foreign guidelines and a generalization of retrospective analyzes on the feasibility of prescribing systemic antifungal drugs for candidal lesions of the oral mucosa and possible methods of correction for mycoecological disorders in children are given. In the context of the presented problem, an integrated approach of a primary care physician, dentist and pediatrician to the diagnosis and treatment of oropharyngeal candidiasis in children is recommended. Timely diagnosis of oropharyngeal candidiasis in children, individual selection of antifungal drugs, synbiotics and multicomponent agents based on probiotics should be a priority area of joint work of general practitioners — family physicians, pediatricians and dentists.
近年来的科学研究提高了临床医生对微生物在维持健康和疾病发生中的作用的兴趣。在大多数情况下，口腔黏膜真菌病变是多种躯体疾病的一种表现形式，也是其治疗的结果和并发症的诱因。为撰写本文，我们使用 Scopus、Web of Science、Med Zine、Pub Med、Google Scholar 等数据库进行了信息检索，并参考了新版《国际疾病分类》（ICD-11）和《合理使用抗菌和抗真菌药物进行治疗和预防》（2023 年）护理标准。综述介绍了世界文献中关于真菌感染在儿童口咽念珠菌病发病中的作用、其形成机制、临床表现和诊断的最新观点。此外，还对国内外指南的建议进行了比较分析，并对口腔黏膜念珠菌病变处方全身抗真菌药物的可行性进行了回顾性分析，以及对儿童霉菌性生态失调的可能矫正方法进行了归纳总结。针对所提出的问题，建议采用由初级保健医生、牙医和儿科医生共同参与的综合方法来诊断和治疗儿童口咽念珠菌病。及时诊断儿童口咽念珠菌病，单独选择抗真菌药物、合生素和基于益生菌的多成分制剂，应成为全科医生--家庭医生、儿科医生和牙科医生联合工作的优先领域。
{"title":"Oropharyngeal candidiasis — interdisciplinary aspects of childhood medicine","authors":"S.O. Mokia-Serbina, V.I. Fesenko","doi":"10.22141/2224-0551.19.4.2024.1711","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1711","url":null,"abstract":"Scientific research in recent years has increased the interest of clinicians in the role of microorganisms in maintaining health and the occurrence of diseases. In most cases, fungal lesions of the oral mucosa are a manifestation of numerous somatic diseases and the results of their treatment and contribute to complications. To write this article, the information was searched using the databases Scopus, Web of Science, Med Zine, Pub Med, Google Scholar, the new version of the International Classification of Diseases (ICD-11) and the Standards of Care “Rational use of antibacterial and antifungal drugs for therapeutic and prophylactic purposes” (2023) were taken into account. The review presents data from the world literature on the role of fungal infection in the development of oropharyngeal candidiasis in children, current perspectives on the mechanism of its formation, clinical manifestations and diagnosis. A comparative characterization of the recommendations of national and foreign guidelines and a generalization of retrospective analyzes on the feasibility of prescribing systemic antifungal drugs for candidal lesions of the oral mucosa and possible methods of correction for mycoecological disorders in children are given. In the context of the presented problem, an integrated approach of a primary care physician, dentist and pediatrician to the diagnosis and treatment of oropharyngeal candidiasis in children is recommended. Timely diagnosis of oropharyngeal candidiasis in children, individual selection of antifungal drugs, synbiotics and multicomponent agents based on probiotics should be a priority area of joint work of general practitioners — family physicians, pediatricians and dentists.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1706
O.Yu. Belousova, N. Pavlenko, K. Voloshyn, I. G. Solodovnichenko, O. M. Вabadzhanian, O. V. Shutova, L. G. Voloshyna, O. B. Hanzii
Background. The relevance is associated with a significant spread of dyspeptic symptoms in children. On average, every third-fourth child with such symptoms complains of heartburn, which is a frequent reason for consulting a doctor. For the pediatric category of patients, not only the timely diagnosis and effective treatment of pathological conditions associated with heartburn are important, but also the awareness of the parents of our patients and the children themselves about the possibilities of providing adequate first aid, safe and effective use of effective non-medicinal means. The purpose: to study the clinical effectiveness of using the special drink ISOTA for the first aid and preliminary treatment of children with heartburn in non-erosive reflux disease, functional dyspepsia and a combination of these conditions (overlap of non-erosive gastroesophageal reflux disease and functional dyspepsia). Materials and methods. Design: a single-center, open-label, pilot clinical trial. Fifty-four children aged 7–18 years with heartburn and other dyspeptic complaints were under observation. The study included 2 stages. The diagnosis was verified by means of surveys (GERDQ and QOLRAD questionnaires) and the use of fibrogastroscopy, endoscopic pH-metry. The results were recorded in the developed individual patient card and statistically processed. Results. Results of the study presented in the corresponding section testify to the high effectiveness of using ISOTA to eliminate heartburn and reduce other dyspeptic symptoms, as well as to a reliable improvement in the psychoemotional state, general well-being and quality of life of patients. Conclusions. The obtained results make it possible to recommend a slightly carbonated hydrocarbonate-containing special drink developed in Ukraine for a long-term use in a treatment course or as needed, and prophylactically to prevent heartburn and other dyspeptic symptoms in children, taking into account the high profile of effectiveness, safety and good tolerability.
{"title":"A child is worried about heartburn: modern views on the problem and possibilities of non-pharmacological support","authors":"O.Yu. Belousova, N. Pavlenko, K. Voloshyn, I. G. Solodovnichenko, O. M. Вabadzhanian, O. V. Shutova, L. G. Voloshyna, O. B. Hanzii","doi":"10.22141/2224-0551.19.4.2024.1706","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1706","url":null,"abstract":"Background. The relevance is associated with a significant spread of dyspeptic symptoms in children. On average, every third-fourth child with such symptoms complains of heartburn, which is a frequent reason for consulting a doctor. For the pediatric category of patients, not only the timely diagnosis and effective treatment of pathological conditions associated with heartburn are important, but also the awareness of the parents of our patients and the children themselves about the possibilities of providing adequate first aid, safe and effective use of effective non-medicinal means. The purpose: to study the clinical effectiveness of using the special drink ISOTA for the first aid and preliminary treatment of children with heartburn in non-erosive reflux disease, functional dyspepsia and a combination of these conditions (overlap of non-erosive gastroesophageal reflux disease and functional dyspepsia). Materials and methods. Design: a single-center, open-label, pilot clinical trial. Fifty-four children aged 7–18 years with heartburn and other dyspeptic complaints were under observation. The study included 2 stages. The diagnosis was verified by means of surveys (GERDQ and QOLRAD questionnaires) and the use of fibrogastroscopy, endoscopic pH-metry. The results were recorded in the developed individual patient card and statistically processed. Results. Results of the study presented in the corresponding section testify to the high effectiveness of using ISOTA to eliminate heartburn and reduce other dyspeptic symptoms, as well as to a reliable improvement in the psychoemotional state, general well-being and quality of life of patients. Conclusions. The obtained results make it possible to recommend a slightly carbonated hydrocarbonate-containing special drink developed in Ukraine for a long-term use in a treatment course or as needed, and prophylactically to prevent heartburn and other dyspeptic symptoms in children, taking into account the high profile of effectiveness, safety and good tolerability.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1708
L.M. Bulat, O. Lysunets, N. Didyk
Background. General physicians often encounter preterm infants and adverse sequelae of prematurity-related morbidities. Interruption of intrauterine development leads to considerable deficits in the internal organs structure and function. It can lead to endothelial dysfunction, hypertension, proteinuria and metabolic abnormalities that persist throughout life. Children born early or low birth weight (LBW) infants also have relatively increased risk for the development of kidney injury later in life. Often these infants have history of treatment at the intensive care unit due to hypoxic damage or inflammatory response that also affects kidneys necessitating the use of nephrotoxic medications. The treatment and diagnosis outcomes were applied to make a conclusion about clinical features of the preterm 7-month-old girl. The data were analyzed using PubMed/MEDLINE and Google Scholar databases. The aim is to summarize particulars of breastfeeding period in a LBW baby, providing a physician with practical information regarding organization of a follow-up. Material and methods. The baby was moderately preterm (32–33 weeks of gestation) with LBW (2100 g). Her mother was consulted regarding hypertension and threat of miscarriage during pregnancy. The child had renal borderline states in the newborn period. Apgar score was low, neonatal resuscitation and respiratory support by the continuous positive airway pressure were used. The newborn had poor regulation of body temperature, depended on environmental factors and prone to rapid heat loss, so she was nursed in incubator. A feeding tube was used despite poor sucking at the first days after delivery and breastfeeding was continued as soon as possible. Eventually, formula feeding was started. Results. Fever, vomiting, dehydration, loss of body weight and oliguria appeared in the 7-month-old baby after the upper respiratory tract infection. Examination showed the stigmas, neurodevelopmental delay, physical growth gap. Blood tests revealed anemia of the first stage and a rapid increase in the level of white blood cells with a left shift and electrolyte imbalance. The laboratory tests of primary and secondary hemostasis were normal. Physical, chemical and microscopic urine properties were changed according to results of urine test. The sonography revealed changes in renal tissue and thymic hyperplasia. The child was diagnosed with acute pyelonephritis and treated. Conclusions. Physicians should focus attention on the stigmas, neurodevelopmental delay, physical growth gap, life history, clinical signs and results of examination to make timely conclusion about child’s general state. Kidney injury could be diagnosed in preterm LBW infants.
{"title":"Particulars of breastfeeding age in preterm child (case report)","authors":"L.M. Bulat, O. Lysunets, N. Didyk","doi":"10.22141/2224-0551.19.4.2024.1708","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1708","url":null,"abstract":"Background. General physicians often encounter preterm infants and adverse sequelae of prematurity-related morbidities. Interruption of intrauterine development leads to considerable deficits in the internal organs structure and function. It can lead to endothelial dysfunction, hypertension, proteinuria and metabolic abnormalities that persist throughout life. Children born early or low birth weight (LBW) infants also have relatively increased risk for the development of kidney injury later in life. Often these infants have history of treatment at the intensive care unit due to hypoxic damage or inflammatory response that also affects kidneys necessitating the use of nephrotoxic medications. The treatment and diagnosis outcomes were applied to make a conclusion about clinical features of the preterm 7-month-old girl. The data were analyzed using PubMed/MEDLINE and Google Scholar databases. The aim is to summarize particulars of breastfeeding period in a LBW baby, providing a physician with practical information regarding organization of a follow-up. Material and methods. The baby was moderately preterm (32–33 weeks of gestation) with LBW (2100 g). Her mother was consulted regarding hypertension and threat of miscarriage during pregnancy. The child had renal borderline states in the newborn period. Apgar score was low, neonatal resuscitation and respiratory support by the continuous positive airway pressure were used. The newborn had poor regulation of body temperature, depended on environmental factors and prone to rapid heat loss, so she was nursed in incubator. A feeding tube was used despite poor sucking at the first days after delivery and breastfeeding was continued as soon as possible. Eventually, formula feeding was started. Results. Fever, vomiting, dehydration, loss of body weight and oliguria appeared in the 7-month-old baby after the upper respiratory tract infection. Examination showed the stigmas, neurodevelopmental delay, physical growth gap. Blood tests revealed anemia of the first stage and a rapid increase in the level of white blood cells with a left shift and electrolyte imbalance. The laboratory tests of primary and secondary hemostasis were normal. Physical, chemical and microscopic urine properties were changed according to results of urine test. The sonography revealed changes in renal tissue and thymic hyperplasia. The child was diagnosed with acute pyelonephritis and treated. Conclusions. Physicians should focus attention on the stigmas, neurodevelopmental delay, physical growth gap, life history, clinical signs and results of examination to make timely conclusion about child’s general state. Kidney injury could be diagnosed in preterm LBW infants.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1710
O. Abaturov, A. Nikulina, O. Rusakova
The literature review deals with DNA methylation, a key epigenetic mechanism that controls the activity of gene transcription, plays a decisive role in the formation of genomic imprinting, gene silencing, X-chromosome inactivation, RNA splicing, DNA repair, cell differentiation and cell reprogramming, and also determines the occurrence and development of liver steatotic lesions and metabolic disorders. Methylation of DNA cytosine dinucleotide (CpG) can be represented in two types: de novo CpG methylation, which is carried out by 5mC DNA writers — DNA-(cytosine-5)-methyltransferase (DNMT) 3a and 3b, and supporting DNA methylation, which is performed by DNMT1 during DNA replication. It has been found that the maintenance DNA methylation allows the preservation of the methylation pattern characteristic of progenitor cells in the cells of the new generation, and the DNA methylation of the gene body is associated with its increased expression. Active demethylation of 5mC is carried out by TET dioxygenases, including three enzymatic representatives: TET1, TET2 and TET3. It has been demonstrated that aberrant methylation of DNA nucleotides is directly related to the activity of lipid synthesis, the degree of oxidative stress, the development of liver steatosis, low-grade inflammation, insulin resistance, and the progression of liver fibrosis. The authors presented in detail the functions and features of DNA methyltransferases, erasers, and readers of 5mC sites; possible violations of the balance of activity of writers and erasers of 5mC DNA; DNA methylation landscape and patterns; clinical significance of DNA methylation signatures in metabolic dysfunction-associated fatty liver disease. Global hypomethylation of genome, at least 55 genes, is observed in patients with metabolic dysfunction-associated fatty liver disease. The authors emphasize that the use of DNA methylation signatures is a promising direction for early diagnosis and prognosis of the course of metabolic dysfunction-associated fatty liver disease, while the study of molecular components of DNA methylation mechanisms involved in the regulation of gene expression, the dependence of their activity on exposure to the exposome will allow to personalize and improve recommendations for lifestyle and diet modification in patients with metabolic dysfunction-associated fatty liver disease.
DNA 甲基化是一种关键的表观遗传机制，它控制着基因转录的活性，在基因组印记的形成、基因沉默、X 染色体失活、RNA 剪接、DNA 修复、细胞分化和细胞重编程等方面起着决定性作用，还决定着肝脏脂肪变性病变和代谢紊乱的发生和发展。DNA 胞嘧啶二核苷酸（CpG）的甲基化可分为两种类型：一种是由 5mC DNA 写手--DNA-（胞嘧啶-5）甲基转移酶（DNMT）3a 和 3b 进行的新生 CpG 甲基化；另一种是由 DNMT1 在 DNA 复制过程中进行的支持性 DNA 甲基化。研究发现，维持 DNA 甲基化可在新一代细胞中保留祖细胞特有的甲基化模式，而基因体的 DNA 甲基化与其表达的增加有关。5mC 的主动去甲基化是由 TET 二氧化酶进行的，其中包括三种酶代表：TET1、TET2 和 TET3。研究表明，DNA 核苷酸的异常甲基化与脂质合成的活性、氧化应激的程度、肝脏脂肪变性的发展、低度炎症、胰岛素抵抗和肝纤维化的进展直接相关。作者详细介绍了 5mC 位点的 DNA 甲基转移酶、擦除器和阅读器的功能和特点；可能违反 5mC DNA 写入器和擦除器活性平衡的情况；DNA 甲基化景观和模式；DNA 甲基化特征在代谢功能障碍相关性脂肪肝中的临床意义。代谢功能障碍相关性脂肪肝患者的基因组（至少 55 个基因）出现全球性低甲基化。作者强调，DNA 甲基化特征的使用是代谢功能障碍相关性脂肪肝病程早期诊断和预后的一个很有前景的方向，而对参与基因表达调控的 DNA 甲基化机制的分子成分及其活性对暴露于暴露组的依赖性的研究，将有助于对代谢功能障碍相关性脂肪肝患者的生活方式和饮食调整提出个性化建议并加以改进。
{"title":"Aberrant DNA methylation associated with the development of metabolic dysfunction-associated fatty liver disease","authors":"O. Abaturov, A. Nikulina, O. Rusakova","doi":"10.22141/2224-0551.19.4.2024.1710","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1710","url":null,"abstract":"The literature review deals with DNA methylation, a key epigenetic mechanism that controls the activity of gene transcription, plays a decisive role in the formation of genomic imprinting, gene silencing, X-chromosome inactivation, RNA splicing, DNA repair, cell differentiation and cell reprogramming, and also determines the occurrence and development of liver steatotic lesions and metabolic disorders. Methylation of DNA cytosine dinucleotide (CpG) can be represented in two types: de novo CpG methylation, which is carried out by 5mC DNA writers — DNA-(cytosine-5)-methyltransferase (DNMT) 3a and 3b, and supporting DNA methylation, which is performed by DNMT1 during DNA replication. It has been found that the maintenance DNA methylation allows the preservation of the methylation pattern characteristic of progenitor cells in the cells of the new generation, and the DNA methylation of the gene body is associated with its increased expression. Active demethylation of 5mC is carried out by TET dioxygenases, including three enzymatic representatives: TET1, TET2 and TET3. It has been demonstrated that aberrant methylation of DNA nucleotides is directly related to the activity of lipid synthesis, the degree of oxidative stress, the development of liver steatosis, low-grade inflammation, insulin resistance, and the progression of liver fibrosis. The authors presented in detail the functions and features of DNA methyltransferases, erasers, and readers of 5mC sites; possible violations of the balance of activity of writers and erasers of 5mC DNA; DNA methylation landscape and patterns; clinical significance of DNA methylation signatures in metabolic dysfunction-associated fatty liver disease. Global hypomethylation of genome, at least 55 genes, is observed in patients with metabolic dysfunction-associated fatty liver disease. The authors emphasize that the use of DNA methylation signatures is a promising direction for early diagnosis and prognosis of the course of metabolic dysfunction-associated fatty liver disease, while the study of molecular components of DNA methylation mechanisms involved in the regulation of gene expression, the dependence of their activity on exposure to the exposome will allow to personalize and improve recommendations for lifestyle and diet modification in patients with metabolic dysfunction-associated fatty liver disease.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"21 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-28DOI: 10.22141/2224-0551.19.4.2024.1705
K. Bodnia, A.M. Zosimov, І.M. Asoyan, V.V. Kondratyuk, T.І. Navet, E. Khodosh, V.D. Makarenko
Background. A child’s body as a functional system is formed starting from the fetal period. Therefore, analysis of even distant in time situations allows to identify factors that affect the functioning of the child’s body in the present time and, possibly, the effectiveness of chemoprophylaxis in children. Materials and methods. To study the presence of a correlation between factors of postembryonic ontogeny and the effectiveness of chemoprophylaxis of tuberculosis in children, an analysis was carried out of 300 patients aged 0 to 17 years in the early period of primary tuberculosis infection, who underwent a 3-month course of chemoprophylaxis with isoniazid. The dynamics of shin sensitivity according to the Mantoux test with 2 tuberculin units was used as a criterion for the effectiveness of chemoprophylaxis. Depending on the latter, the examinees were divided into two groups: a group with effective chemoprophylaxis (n = 200), in which the size of a wheal after the end of the course decreased by 4 mm or more, and a group with ineffective chemoprophylaxis, in which skin sensitivity to tuberculin increased or remained at the previous level or decreased in the size of a wheal by 3 mm or less. Results. The analysis showed that in the group with ineffective chemoprophylaxis compared to the alternative group, the following occurred significantly more often: short-term (up to 4 months) breast feeding, a history of acute bronchitis (p < 0.001) in a child, acute obstructive bronchitis. In addition, the following were characteristic of this group: the presence of tuberculosis contact (p < 0.001), tuberculosis contact with a patient with confirmed bacterial excretion (p < 0.001), age of child under 6 years (p < 0.001), the number (two and more) of concomitant pathologies (p < 0.001), a single BCG vaccination (p < 0.001), as well as the winter seasonality of chemoprophylaxis (p < 0.05). Conclusions. Significant correlations have been found between many factors of postembryonic ontogeny and the effectiveness of tuberculosis chemoprophylaxis in children, which allows them to be used for prognostic purposes. The closest connections with the effectiveness of chemoprophylaxis of tuberculosis in children was revealed for the presence of tuberculosis contact (ϕ = 1.08; p < 0.001), especially with a patient with confirmed bacterial excretion (ϕ = 1.72; p < 0.001), as well as the number of concomitant pathologies in a child (ϕ = 0.70; p < 0.001) and manifestations of allergy (ϕ = 0.67; p < 0.001).
{"title":"Factors of postembryonic ontogeny: relationship with the effectiveness of tuberculosis chemoprophylaxis in children","authors":"K. Bodnia, A.M. Zosimov, І.M. Asoyan, V.V. Kondratyuk, T.І. Navet, E. Khodosh, V.D. Makarenko","doi":"10.22141/2224-0551.19.4.2024.1705","DOIUrl":"https://doi.org/10.22141/2224-0551.19.4.2024.1705","url":null,"abstract":"Background. A child’s body as a functional system is formed starting from the fetal period. Therefore, analysis of even distant in time situations allows to identify factors that affect the functioning of the child’s body in the present time and, possibly, the effectiveness of chemoprophylaxis in children. Materials and methods. To study the presence of a correlation between factors of postembryonic ontogeny and the effectiveness of chemoprophylaxis of tuberculosis in children, an analysis was carried out of 300 patients aged 0 to 17 years in the early period of primary tuberculosis infection, who underwent a 3-month course of chemoprophylaxis with isoniazid. The dynamics of shin sensitivity according to the Mantoux test with 2 tuberculin units was used as a criterion for the effectiveness of chemoprophylaxis. Depending on the latter, the examinees were divided into two groups: a group with effective chemoprophylaxis (n = 200), in which the size of a wheal after the end of the course decreased by 4 mm or more, and a group with ineffective chemoprophylaxis, in which skin sensitivity to tuberculin increased or remained at the previous level or decreased in the size of a wheal by 3 mm or less. Results. The analysis showed that in the group with ineffective chemoprophylaxis compared to the alternative group, the following occurred significantly more often: short-term (up to 4 months) breast feeding, a history of acute bronchitis (p < 0.001) in a child, acute obstructive bronchitis. In addition, the following were characteristic of this group: the presence of tuberculosis contact (p < 0.001), tuberculosis contact with a patient with confirmed bacterial excretion (p < 0.001), age of child under 6 years (p < 0.001), the number (two and more) of concomitant pathologies (p < 0.001), a single BCG vaccination (p < 0.001), as well as the winter seasonality of chemoprophylaxis (p < 0.05). Conclusions. Significant correlations have been found between many factors of postembryonic ontogeny and the effectiveness of tuberculosis chemoprophylaxis in children, which allows them to be used for prognostic purposes. The closest connections with the effectiveness of chemoprophylaxis of tuberculosis in children was revealed for the presence of tuberculosis contact (ϕ = 1.08; p < 0.001), especially with a patient with confirmed bacterial excretion (ϕ = 1.72; p < 0.001), as well as the number of concomitant pathologies in a child (ϕ = 0.70; p < 0.001) and manifestations of allergy (ϕ = 0.67; p < 0.001).","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"13 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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