The rapid increase in the world population causes different problems such as nutrition and shelter. In this case, people brutally destroy arable land to shelter, and concretization is rapidly spreading. In addition, it is necessary to increase the amount of products to be taken from the limited agricultural areas for the food needs of the increasing population. The decrease in agricultural areas appears as a factor that reduces the amount of product taken from the unit area. In addition, weeds and especially insects reduce the yield, storage, and marketing quality of products obtained from restricted areas. This type of plant products can also be considered a disease carrier vector in the food chain. To increase the yield, various insecticides have been developed against target organisms such as insects and one of these insecticides is α-endosulfan. However, non-target organisms living in the same ecosystem can also be affected by all these insecticides. In the present study, it was researched whether the chronic α-endosulfan application has an effect on longevity in non-target organisms. According to the data obtained, α-endosulfan shortened the maximum and mean lifespan in both male and female populations of the Oregon-R wild strain of Drosophila melanogaster based on dose-time interaction. The shortening observed in life span for both populations was statistically significant (p
{"title":"Longevity toxicity after chronic α -endosulfan exposure in wild population of Drosophila melanogaster Oregon-R (Diptera: Drosophilidae)","authors":"H. Uysal","doi":"10.46239/ejbcs.1271311","DOIUrl":"https://doi.org/10.46239/ejbcs.1271311","url":null,"abstract":"The rapid increase in the world population causes different problems such as nutrition and shelter. In this case, people brutally destroy arable land to shelter, and concretization is rapidly spreading. In addition, it is necessary to increase the amount of products to be taken from the limited agricultural areas for the food needs of the increasing population. The decrease in agricultural areas appears as a factor that reduces the amount of product taken from the unit area. In addition, weeds and especially insects reduce the yield, storage, and marketing quality of products obtained from restricted areas. This type of plant products can also be considered a disease carrier vector in the food chain. To increase the yield, various insecticides have been developed against target organisms such as insects and one of these insecticides is α-endosulfan. However, non-target organisms living in the same ecosystem can also be affected by all these insecticides. \u0000In the present study, it was researched whether the chronic α-endosulfan application has an effect on longevity in non-target organisms. According to the data obtained, α-endosulfan shortened the maximum and mean lifespan in both male and female populations of the Oregon-R wild strain of Drosophila melanogaster based on dose-time interaction. The shortening observed in life span for both populations was statistically significant (p","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123525293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ionizing alpha radiation (He2+) is known to adversely affect human DNA, but the biochemical reasoning is not clear yet. Relatedly, the present computational study was conducted investigating the effects of ionizing alpha radiation onto the Watson-Crick type DNA base pairs (nucleotides) Adenine-Thymine (AT’) and Guanine-Cytosine (GC’). The long-range cation (He2+)−π interactions were modeled for this purpose. A hybrid DFT functional of M06-2X was used with 6-31G(d,p) and 6-311G(d) basis sets at unrestricted level. The results showed that alpha radiation severely changed the considered base pairs’ hydrogen bond lengths and their interaction enthalpies and Gibbs free energies, however, the more drastic changes were observed in GC’ rather than AT’. This observation was also supported by frontier molecular orbital analyses performed. GC’ was more favored to form He2+ complexes (oxidize) than AT’ and consequently these complexes had more exothermic interaction energies (formed more spontaneously) than that of AT’. It could be highlighted that the molecular modeling proposed in this study would contribute to the elucidation of the uncertainty in this field.
{"title":"Molecular modeling and thermodynamics of the interaction between DNA base pairs and radon originated ionizing alpha radiation","authors":"Ç. Bayar","doi":"10.46239/ejbcs.1225044","DOIUrl":"https://doi.org/10.46239/ejbcs.1225044","url":null,"abstract":"Ionizing alpha radiation (He2+) is known to adversely affect human DNA, but the biochemical reasoning is not clear yet. Relatedly, the present computational study was conducted investigating the effects of ionizing alpha radiation onto the Watson-Crick type DNA base pairs (nucleotides) Adenine-Thymine (AT’) and Guanine-Cytosine (GC’). The long-range cation (He2+)−π interactions were modeled for this purpose. A hybrid DFT functional of M06-2X was used with 6-31G(d,p) and 6-311G(d) basis sets at unrestricted level. The results showed that alpha radiation severely changed the considered base pairs’ hydrogen bond lengths and their interaction enthalpies and Gibbs free energies, however, the more drastic changes were observed in GC’ rather than AT’. This observation was also supported by frontier molecular orbital analyses performed. GC’ was more favored to form He2+ complexes (oxidize) than AT’ and consequently these complexes had more exothermic interaction energies (formed more spontaneously) than that of AT’. It could be highlighted that the molecular modeling proposed in this study would contribute to the elucidation of the uncertainty in this field.","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"277 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134316562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bu çalışmada, 2019-2020 yılları arasında Malatya ilinden toplanan sucul kolopter türleri değerlendirilmiştir. Araştırma bölgesinde, yedi familyaya (Dryopidae, Dytiscidae, Helophoridae, Hydrophilidae, Hydrochidae, Haliplidae ve Noteridae) ait 21 tür tespit edilmiştir. Tespit edilen türlerin 14 tanesi Malatya ili için yeni kayıttır.
{"title":"Contributions to the Knowledge of Aquatic Insect (Coleoptera) Fauna in Malatya Province","authors":"G. Tasar","doi":"10.46239/ejbcs.1215756","DOIUrl":"https://doi.org/10.46239/ejbcs.1215756","url":null,"abstract":"Bu çalışmada, 2019-2020 yılları arasında Malatya ilinden toplanan sucul kolopter türleri değerlendirilmiştir. Araştırma bölgesinde, yedi familyaya (Dryopidae, Dytiscidae, Helophoridae, Hydrophilidae, Hydrochidae, Haliplidae ve Noteridae) ait 21 tür tespit edilmiştir. Tespit edilen türlerin 14 tanesi Malatya ili için yeni kayıttır.","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121150853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bu çalışmada, metilal/metanol karışımlarının ayrılması için pervaporasyon işlemi kullanılmıştır. Metanole afinitesinden dolayı membran hazırlamak için polieterimid (PEI) polimeri seçilmiştir. ZIF-8, membran için katkı maddesi olarak kullanılmıştır. ZIF-8 katkılı PEI membranı sentezlenmiş ve karakterize edilmiştir. Membranların kimyasal bağ yapısı, termal dayanımı ve morfolojisi sıraısyla Fourier dönüşümü kızılötesi spektroskopisi (FTIR), Termogravimetrik Analiz (TGA) ve Taramalı elektron mikroskobu (SEM) ile analiz edilmiştir. Membranların ayırma performansı farklı çalışma sıcaklıklarında, farklı besleme metanol konsantrasyonlarında ve farklı ZIF-8 yükleme oranlarında incelenmiştir. Optimum proses koşulları, 20°C operasyon sıcaklığı, ağırlıkça %6 besleme metanol konsantrasyonu ve ağırlıkça %0.5 ZIF-8 yükleme oranı olarak belirlenmiştir. Akı ve metanol seçicilik değerleri bu koşullar altında sırasıyla 0.57 kg/m2h akı ve 8169 metanol seçiciliği olarak belirlenmiştir.
{"title":"Purification of methylal/methanol mixtures by pervaporation process using ZIF-8 doped PEI membrane","authors":"D. Ünlü","doi":"10.46239/ejbcs.1226164","DOIUrl":"https://doi.org/10.46239/ejbcs.1226164","url":null,"abstract":"Bu çalışmada, metilal/metanol karışımlarının ayrılması için pervaporasyon işlemi kullanılmıştır. Metanole afinitesinden dolayı membran hazırlamak için polieterimid (PEI) polimeri seçilmiştir. ZIF-8, membran için katkı maddesi olarak kullanılmıştır. ZIF-8 katkılı PEI membranı sentezlenmiş ve karakterize edilmiştir. Membranların kimyasal bağ yapısı, termal dayanımı ve morfolojisi sıraısyla Fourier dönüşümü kızılötesi spektroskopisi (FTIR), Termogravimetrik Analiz (TGA) ve Taramalı elektron mikroskobu (SEM) ile analiz edilmiştir. Membranların ayırma performansı farklı çalışma sıcaklıklarında, farklı besleme metanol konsantrasyonlarında ve farklı ZIF-8 yükleme oranlarında incelenmiştir. Optimum proses koşulları, 20°C operasyon sıcaklığı, ağırlıkça %6 besleme metanol konsantrasyonu ve ağırlıkça %0.5 ZIF-8 yükleme oranı olarak belirlenmiştir. Akı ve metanol seçicilik değerleri bu koşullar altında sırasıyla 0.57 kg/m2h akı ve 8169 metanol seçiciliği olarak belirlenmiştir.","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126409596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Dalga, G. Kirbaş Doğan, Y. Akbulut, T. Çeti̇n, V. Kızılgöz
The aim of this study is to reveal the macroscopic features of the brown bear (Ursus arctos) os penis (baculum), as well as its morphometric measurements with the help of computerized tomography and digital electronic caliper. The study material was obtained from an adult male brown bear weighing approximately 400 kg, which was brought to the Wildlife Protection and Rehabilitation Unit of Kafkas University and died as a result of a traffic accident in the Sarıkamış district of Kars. After the skin and soft tissues around the baculum were removed, they were kept in hydrogen peroxide for 2-3 hours. In the macroscopic examination, it was determined that the baculum was straight, close to the pen, except for a slight curve in the distal part, and ended with a small tubercle at the distal end. A small notch was found in the proximal part. In addition to the prominent sulcus urethralis in the ventral of the baculum, a short groove was also detected in its lateral. In addition to the prominent sulcus urethralis in the ventral of the baculum, a short groove was also detected in its lateral. A cartilage tissue of 11.08 mm in length and 4.67 mm in thickness was determined in the distal of the bone. In the morphometric measurements made with a digital electronic caliper, the length of the baculum was 148.95 mm, while the diameters were measured as 4.58 mm in the distal and 13.72 mm in the proximal, respectively. In computed tomography, baculum length was 148.84 mm, distal diameter length was 5.63 mm, and proximal diameter length was 13.12 mm. In addition, computed tomography measured the length of the cortex as 0.76 mm, the length of the medulla as 5.74 mm in the distal, and the cortex length of 0.77 mm and the medulla length of 5.32 mm in the proximal region. As a result, in this study, the macroanatomical and morphometric features of the brown bear baculum, which live in high altitude and cold climate conditions, were revealed.
{"title":"CT Imaging, Macroanatomical and Morphometric Analysis of Os penis in Brown Bear (Ursus arctos)","authors":"S. Dalga, G. Kirbaş Doğan, Y. Akbulut, T. Çeti̇n, V. Kızılgöz","doi":"10.46239/ejbcs.1082216","DOIUrl":"https://doi.org/10.46239/ejbcs.1082216","url":null,"abstract":"The aim of this study is to reveal the macroscopic features of the brown bear (Ursus arctos) os penis (baculum), as well as its morphometric measurements with the help of computerized tomography and digital electronic caliper. The study material was obtained from an adult male brown bear weighing approximately 400 kg, which was brought to the Wildlife Protection and Rehabilitation Unit of Kafkas University and died as a result of a traffic accident in the Sarıkamış district of Kars. After the skin and soft tissues around the baculum were removed, they were kept in hydrogen peroxide for 2-3 hours. In the macroscopic examination, it was determined that the baculum was straight, close to the pen, except for a slight curve in the distal part, and ended with a small tubercle at the distal end. A small notch was found in the proximal part. In addition to the prominent sulcus urethralis in the ventral of the baculum, a short groove was also detected in its lateral. In addition to the prominent sulcus urethralis in the ventral of the baculum, a short groove was also detected in its lateral. A cartilage tissue of 11.08 mm in length and 4.67 mm in thickness was determined in the distal of the bone. In the morphometric measurements made with a digital electronic caliper, the length of the baculum was 148.95 mm, while the diameters were measured as 4.58 mm in the distal and 13.72 mm in the proximal, respectively. In computed tomography, baculum length was 148.84 mm, distal diameter length was 5.63 mm, and proximal diameter length was 13.12 mm. In addition, computed tomography measured the length of the cortex as 0.76 mm, the length of the medulla as 5.74 mm in the distal, and the cortex length of 0.77 mm and the medulla length of 5.32 mm in the proximal region. As a result, in this study, the macroanatomical and morphometric features of the brown bear baculum, which live in high altitude and cold climate conditions, were revealed.","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122252638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yavuz Mahmut, Abdul-hameed M. HAMOODY, R. Abdulqader
The aim of this study is isolate and identify fungi from different habitat in Kirkuk City - Iraq. The fungal species were isolated from soil and water in four season 2021-2022, collected the samples from various geographical habitat in Kirkuk City. The fungi isolation from soil and water done by inoculating (1ml) from serial dilutions on Potato Dextrose Agar (PDA) plates. The molecular identification of the isolated fungi at the species level, by PCR using specific internal transcribed spacer primer (ITS1/ITS4). The PCR products were sequenced and compared with the other related sequences in GenBank (NCBI). Seven fungal species were identified. The results showed that the (Aspergillus flavus 20.83%) was the most abundant fungus, while the (Penicillium citrinum 8.30%) was the less prevalent one in all resources and locations. The seven local fungal isolates were registered within NCBI, and this is the first record of these isolates in Iraq
{"title":"Morphological and molecular identification of fungi isolated from various habitat in Kirkuk city – Iraq","authors":"Yavuz Mahmut, Abdul-hameed M. HAMOODY, R. Abdulqader","doi":"10.46239/ejbcs.1276554","DOIUrl":"https://doi.org/10.46239/ejbcs.1276554","url":null,"abstract":"The aim of this study is isolate and identify fungi from different habitat in Kirkuk City - Iraq. The fungal species were isolated from soil and water in four season 2021-2022, collected the samples from various geographical habitat in Kirkuk City. The fungi isolation from soil and water done by inoculating (1ml) from serial dilutions on Potato Dextrose Agar (PDA) plates. The molecular identification of the isolated fungi at the species level, by PCR using specific internal transcribed spacer primer (ITS1/ITS4). The PCR products were sequenced and compared with the other related sequences in GenBank (NCBI). Seven fungal species were identified. The results showed that the (Aspergillus flavus 20.83%) was the most abundant fungus, while the (Penicillium citrinum 8.30%) was the less prevalent one in all resources and locations. The seven local fungal isolates were registered within NCBI, and this is the first record of these isolates in Iraq","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121125273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Murad Guli̇yev, E. Şen, Borane Çalışkan, G. Tetik, E. Tarhan, Ö. Tarhan
Electrohydrodynamic atomization that is also defined as electrospraying is a method of producing mats that are composed of nano- or micro-scaled droplets. Unlike nanofibers that are obtained by electrospinning, the droplets are in spherical forms, and this is the result of the struggle between the applied electrostatic forces and the surface tension of the liquid (meaning polymer solution). This study aims to prepare and characterize electrosprayed biopolymer mats. The 1:2 blend of HWPC (hydrolyzed whey protein concentrate): PEO (poly (ethylene oxide)) is the polymer solution prepared in 2.5% aqueous acetic acid solvent. Physicochemical, morphological and structural analysis are applied to both solution and the electrosprayed mat. Increased viscosity in the protein solution by the addition of PEO enhanced the formation of regular beads observed through SEM images. Image J Visualization and Measurement Software was occupied to determine the diameter distributions of the droplets forming the mat. The mean diameter was found as 1.02±0.55 µm. ATR-FTIR spectroscopy analyses revealed remarkable structural changes in protein and interaction between protein and PEO in the electrosprayed mats. The HWPC/ PEO electrosprayed mat coating revealed one log decrease in the microbial load of fresh figs at the end of fourteen-day storage (4ºC). The findings of the presented research are promising for the application of this electrosprayed biopolymer mat for food coating purposes.
{"title":"Electrosprayed WPC/PEO Mats Coated to Fresh Figs","authors":"Murad Guli̇yev, E. Şen, Borane Çalışkan, G. Tetik, E. Tarhan, Ö. Tarhan","doi":"10.46239/ejbcs.1214572","DOIUrl":"https://doi.org/10.46239/ejbcs.1214572","url":null,"abstract":"Electrohydrodynamic atomization that is also defined as electrospraying is a method of producing mats that are composed of nano- or micro-scaled droplets. Unlike nanofibers that are obtained by electrospinning, the droplets are in spherical forms, and this is the result of the struggle between the applied electrostatic forces and the surface tension of the liquid (meaning polymer solution). This study aims to prepare and characterize electrosprayed biopolymer mats. The 1:2 blend of HWPC (hydrolyzed whey protein concentrate): PEO (poly (ethylene oxide)) is the polymer solution prepared in 2.5% aqueous acetic acid solvent. Physicochemical, morphological and structural analysis are applied to both solution and the electrosprayed mat. Increased viscosity in the protein solution by the addition of PEO enhanced the formation of regular beads observed through SEM images. Image J Visualization and Measurement Software was occupied to determine the diameter distributions of the droplets forming the mat. The mean diameter was found as 1.02±0.55 µm. ATR-FTIR spectroscopy analyses revealed remarkable structural changes in protein and interaction between protein and PEO in the electrosprayed mats. The HWPC/ PEO electrosprayed mat coating revealed one log decrease in the microbial load of fresh figs at the end of fourteen-day storage (4ºC). The findings of the presented research are promising for the application of this electrosprayed biopolymer mat for food coating purposes.","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"880 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122876576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clandestinely, consumers may be exposed to antibiotic (ATB) residues in honey, which could pose a health concern. For the first time, the simultaneous determination of Florfenicol (FF), Penicillin G (PG), and Tetracycline is described in this paper. The multiresidual method was developed and optimized using high-performance liquid chromatography (HPLC) coupled to a diode array detector (DAD). These ATBs were separated on a C18 analytical column after a cleanup process followed by solid-phase extraction (SPE). For the first time, the chromatographic conditions were perfected. After the method validation process, the method was used to assess ATB residues in four Lebanese honey samples. ATBs were separated in less than 15 min with an isocratic elution using a mixture of 80 % potassium dihydrogen phosphate aqueous solution, and 20 % acetonitrile. The UV detection was performed at 350 nm for TC, 224 nm for FF, and 230 nm for PG. The proposed method was linear (R2 ≥ 0.996) within the concentration ranges of 0.7-17.5 mg.Kg 1 for the three compounds. Both intra- and inter-day precision, expressed as RSD, were ≤15 %. The method was subsequently successfully applied to analyze examined ATB residues in honey samples collected from Lebanese beekeeping. The method described could be a valuable tool to conduct a comprehensive survey of honey samples produced in Lebanon, especially in the lack of serious national oversight.
{"title":"Multiresidue chromatographic method for the determination of antibiotic residues in honey by high-performance liquid chromatography with DAD detection","authors":"Bouchra Rachi̇d, A. Jaber, Edmond Cheble","doi":"10.46239/ejbcs.1104606","DOIUrl":"https://doi.org/10.46239/ejbcs.1104606","url":null,"abstract":"Clandestinely, consumers may be exposed to antibiotic (ATB) residues in honey, which could pose a health concern. For the first time, the simultaneous determination of Florfenicol (FF), Penicillin G (PG), and Tetracycline is described in this paper. The multiresidual method was developed and optimized using high-performance liquid chromatography (HPLC) coupled to a diode array detector (DAD). These ATBs were separated on a C18 analytical column after a cleanup process followed by solid-phase extraction (SPE). For the first time, the chromatographic conditions were perfected. After the method validation process, the method was used to assess ATB residues in four Lebanese honey samples. ATBs were separated in less than 15 min with an isocratic elution using a mixture of 80 % potassium dihydrogen phosphate aqueous solution, and 20 % acetonitrile. The UV detection was performed at 350 nm for TC, 224 nm for FF, and 230 nm for PG. The proposed method was linear (R2 ≥ 0.996) within the concentration ranges of 0.7-17.5 mg.Kg 1 for the three compounds. Both intra- and inter-day precision, expressed as RSD, were ≤15 %. The method was subsequently successfully applied to analyze examined ATB residues in honey samples collected from Lebanese beekeeping. The method described could be a valuable tool to conduct a comprehensive survey of honey samples produced in Lebanon, especially in the lack of serious national oversight.","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122827242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bu çalışmada çok gözenekli (MSN) ve tek gözenekli (HSS) silika nanopartiküllerin yüzeyinde, viniltriazol (VTri) monomerinin polimerizasyon reaksiyonu ile amin grupları oluşturulmuştur. Hazırlanan nanokompozit yapıların karakterizasyonu ve antifungal özelliği incelenmiştir. Nanokompozitlerin karakterizasyonunda MSN ve HSS' nın viniltriazol ile etkileşimini, yüzeydeki azol gruplarının varlığını belirlemek için FTIR ve XRD analizi, termal özelliklerini incelemek için TGA analizi yapılmıştır. Nanokompozitlerin morfolojisini belirlemek için SEM analizi yapılmıştır. Nanokompozit yapıların antifungal özellikleri MİK yöntemi ile kanıtlanmıştır.
在这项研究中，通过乙烯基三唑（VTri）单体的聚合反应，在多孔（MSN）和单孔（HSS）二氧化硅纳米粒子表面形成了胺基团。研究了所制备纳米复合材料的特性和抗真菌性能。在纳米复合材料的表征过程中，进行了傅立叶变换红外光谱和 XRD 分析，以确定 MSN 和 HSS 与乙烯基三唑的相互作用以及表面是否存在唑基。为了确定纳米复合材料的形态，还进行了 SEM 分析。通过 MIC 方法证明了纳米复合材料结构的抗真菌性能。
{"title":"Azol fonksiyonel gözenekli ve içi boş silika nanokompozitlerin karakterizasyonu ve antifungal uygulamaları","authors":"Sedef KAPTAN USUL, Ayşe Aslan, Didem Özçimen","doi":"10.46239/ejbcs.1033670","DOIUrl":"https://doi.org/10.46239/ejbcs.1033670","url":null,"abstract":"Bu çalışmada çok gözenekli (MSN) ve tek gözenekli (HSS) silika nanopartiküllerin yüzeyinde, viniltriazol (VTri) monomerinin polimerizasyon reaksiyonu ile amin grupları oluşturulmuştur. Hazırlanan nanokompozit yapıların karakterizasyonu ve antifungal özelliği incelenmiştir. Nanokompozitlerin karakterizasyonunda MSN ve HSS' nın viniltriazol ile etkileşimini, yüzeydeki azol gruplarının varlığını belirlemek için FTIR ve XRD analizi, termal özelliklerini incelemek için TGA analizi yapılmıştır. Nanokompozitlerin morfolojisini belirlemek için SEM analizi yapılmıştır. Nanokompozit yapıların antifungal özellikleri MİK yöntemi ile kanıtlanmıştır.","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126050550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the most important challenges in the fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by the ABCB1 gene in many organs, is one of the important factors involved in the development of drug resistance. P-gp is mainly involved in efflux of toxic substances such as xenobiotics from the cell. In addition to these, it also plays a role the efflux of drugs used in the treatment of cancer, the rate of success in cancer treatment reduces. Phenolic compounds are chemicals that are naturally synthesized in plants and have many biological activities, especially antioxidant and anticancer. In previous studies, it was determined that in addition to their anticancer activities, phenolics modulate the acquired drug resistance by inhibiting the expression and function of P-gp. In this review, phenolic compounds that play a role in breaking multi-drug resistance by inhibiting the activation and expression of P-gp are discussed.
{"title":"Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1","authors":"Önder Yumrutaş, Pınar Yumrutaş","doi":"10.46239/ejbcs.1130645","DOIUrl":"https://doi.org/10.46239/ejbcs.1130645","url":null,"abstract":"One of the most important challenges in the fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by the ABCB1 gene in many organs, is one of the important factors involved in the development of drug resistance. P-gp is mainly involved in efflux of toxic substances such as xenobiotics from the cell. In addition to these, it also plays a role the efflux of drugs used in the treatment of cancer, the rate of success in cancer treatment reduces. Phenolic compounds are chemicals that are naturally synthesized in plants and have many biological activities, especially antioxidant and anticancer. In previous studies, it was determined that in addition to their anticancer activities, phenolics modulate the acquired drug resistance by inhibiting the expression and function of P-gp. In this review, phenolic compounds that play a role in breaking multi-drug resistance by inhibiting the activation and expression of P-gp are discussed.","PeriodicalId":338101,"journal":{"name":"Eurasian Journal of Biological and Chemical Sciences","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131401330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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