Pub Date : 2018-11-01DOI: 10.1109/ICBME.2018.8703560
Sobhan Haghparast, E. Fatemizadeh
In this paper a novel method is proposed which uses the concept of image registration to predict frames as a new frame up conversion method. This frame rate up conversion method is specially designed for Ultrasound and other medical videos because of the medical Properties of the non-rigid image registration since medical mediums are usually none rigid used as a new concept to predict new frames which causes better results for these kinds of videos. In this method we interpolate new frames in the field of non-rigid transformation mesh grids in order to improve video parameters such as blocking by factor of 3, blurriness, and etc. which can help experts to detect abnormalities in such videos specially ultrasound videos much preciously.
{"title":"A novel frame rate up-conversion method to decrease blocking and blurring factors using none rigid image registration on medical videos","authors":"Sobhan Haghparast, E. Fatemizadeh","doi":"10.1109/ICBME.2018.8703560","DOIUrl":"https://doi.org/10.1109/ICBME.2018.8703560","url":null,"abstract":"In this paper a novel method is proposed which uses the concept of image registration to predict frames as a new frame up conversion method. This frame rate up conversion method is specially designed for Ultrasound and other medical videos because of the medical Properties of the non-rigid image registration since medical mediums are usually none rigid used as a new concept to predict new frames which causes better results for these kinds of videos. In this method we interpolate new frames in the field of non-rigid transformation mesh grids in order to improve video parameters such as blocking by factor of 3, blurriness, and etc. which can help experts to detect abnormalities in such videos specially ultrasound videos much preciously.","PeriodicalId":338286,"journal":{"name":"2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121457382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/ICBME.2018.8703564
Parsa Moradi, Naghme Nazer, A. K. Ahmadi, H. Mohammadzade, Hasan Khojasteh Jafari
Alternative medicine can be used to achieve the healing effects of the experimental medicine, it also can predict diseases and prevent them, but validity of them is unproven. Iridology is an alternative medicine that claims to predict tissue weaknesses in the body by looking at the iris. The main object of this paper is to validate the using of iridology to predict diabetes, to do so iris images of 106 diabetic patients and 124 healthy controls were obtained and evaluated. The designed method is completely automatic and independent of iridologists. Also a novel algorithm is developed to improve the efficiency by finding the best region of iris automatically. The results showed the accuracy of 91.8% in the best setting, which shows the effectiveness of the proposed method.
{"title":"Discovering Informative Regions in Iris Images to Predict Diabetes","authors":"Parsa Moradi, Naghme Nazer, A. K. Ahmadi, H. Mohammadzade, Hasan Khojasteh Jafari","doi":"10.1109/ICBME.2018.8703564","DOIUrl":"https://doi.org/10.1109/ICBME.2018.8703564","url":null,"abstract":"Alternative medicine can be used to achieve the healing effects of the experimental medicine, it also can predict diseases and prevent them, but validity of them is unproven. Iridology is an alternative medicine that claims to predict tissue weaknesses in the body by looking at the iris. The main object of this paper is to validate the using of iridology to predict diabetes, to do so iris images of 106 diabetic patients and 124 healthy controls were obtained and evaluated. The designed method is completely automatic and independent of iridologists. Also a novel algorithm is developed to improve the efficiency by finding the best region of iris automatically. The results showed the accuracy of 91.8% in the best setting, which shows the effectiveness of the proposed method.","PeriodicalId":338286,"journal":{"name":"2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123950236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/ICBME.2018.8703586
Z. Arjmandi, Dr. Firooz Bakhtiari Nejad, Dr. Mohammad Ali Ahmadi Pajouh
This paper presents the design and fabrication of a polymer-based tendon-driven wearable continuous passive machine for the hand. Passive means the machine is moving the hand and the patients do not actively move his hand. Providing relaxing feeling and easy wearing comfort for people, flexion and extension motions and other biomechanical consideration are the key points to this design in considering the cases of practical use. Thus by using silicone hospital environmental hygiene provided and design features permit adjustment for different hand sizes and protect users from injury. It uses one motor for the index finger and an under-actuation mechanism to grasp various objects. Finally, performance and simultaneous movement of human and robot were verified by comparing the trajectory of mechanism, desired trajectory obtained from healthy hand and simulation. Variance and error came to an acceptable range according to the Ashworth scale.
{"title":"Design, Fabrication and Verification of Continuous Passive Motion Equipment for the Index Finger","authors":"Z. Arjmandi, Dr. Firooz Bakhtiari Nejad, Dr. Mohammad Ali Ahmadi Pajouh","doi":"10.1109/ICBME.2018.8703586","DOIUrl":"https://doi.org/10.1109/ICBME.2018.8703586","url":null,"abstract":"This paper presents the design and fabrication of a polymer-based tendon-driven wearable continuous passive machine for the hand. Passive means the machine is moving the hand and the patients do not actively move his hand. Providing relaxing feeling and easy wearing comfort for people, flexion and extension motions and other biomechanical consideration are the key points to this design in considering the cases of practical use. Thus by using silicone hospital environmental hygiene provided and design features permit adjustment for different hand sizes and protect users from injury. It uses one motor for the index finger and an under-actuation mechanism to grasp various objects. Finally, performance and simultaneous movement of human and robot were verified by comparing the trajectory of mechanism, desired trajectory obtained from healthy hand and simulation. Variance and error came to an acceptable range according to the Ashworth scale.","PeriodicalId":338286,"journal":{"name":"2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125643354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/ICBME.2018.8703533
Arash Khorrami Jahromi, M. Saadatmand, Hamed Shieh, M. Eghbal, L. P. Yeganeh
Applications of microfluidic technologies in medical diagnostics continue to increase, particularly in the field of nucleic acid diagnostics. Although much attention has been focused on the development of nucleic acid amplification and detection platforms, cell lysis procedure, as one of the most fundamental steps of sample preparation have not been taken into consideration sufficiently. In this paper, the design and characterization of a novel centrifugal microfluidic platform for chemical cell lysis is presented. The developed configuration employs passive pneumatic reciprocating mixer and siphon valve for rigorous mixing of lysis buffer and cell samples alongside precise control over fluid flow. Experiments were conducted with white blood cells, separated from human whole blood, to demonstrate the performance. Compared to commercial manual protocol for cell lysing, the experimental results indicated that the proposed method is greatly effective in realizing a chemical cell lysis system on lab-on-a-disc (LoaD) with high throughput in terms of purity and yield of DNA. The developed system provides efficient, simple, and fully automated chemical cell lysis which can be easily integrated into sample-to-answer systems with applications in point-of-care settings
{"title":"Development of an Efficient Centrifugal Microfluidic Platform for Automated Chemical Cell Lysis","authors":"Arash Khorrami Jahromi, M. Saadatmand, Hamed Shieh, M. Eghbal, L. P. Yeganeh","doi":"10.1109/ICBME.2018.8703533","DOIUrl":"https://doi.org/10.1109/ICBME.2018.8703533","url":null,"abstract":"Applications of microfluidic technologies in medical diagnostics continue to increase, particularly in the field of nucleic acid diagnostics. Although much attention has been focused on the development of nucleic acid amplification and detection platforms, cell lysis procedure, as one of the most fundamental steps of sample preparation have not been taken into consideration sufficiently. In this paper, the design and characterization of a novel centrifugal microfluidic platform for chemical cell lysis is presented. The developed configuration employs passive pneumatic reciprocating mixer and siphon valve for rigorous mixing of lysis buffer and cell samples alongside precise control over fluid flow. Experiments were conducted with white blood cells, separated from human whole blood, to demonstrate the performance. Compared to commercial manual protocol for cell lysing, the experimental results indicated that the proposed method is greatly effective in realizing a chemical cell lysis system on lab-on-a-disc (LoaD) with high throughput in terms of purity and yield of DNA. The developed system provides efficient, simple, and fully automated chemical cell lysis which can be easily integrated into sample-to-answer systems with applications in point-of-care settings","PeriodicalId":338286,"journal":{"name":"2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126376808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.1109/ICBME.2018.8703535
Seyyedeh Ensiyeh Hashemi, Mohammad Ali Ahmadi-Pajouh, Elham Shamsi
Electromyography (EMG) is a signal representing the activity of skeletal muscles. Besides, H-reflex and M-wave are two responses to the electrical stimulation of the nerve, and they appear in EMG. In this paper, the purpose was to model the recorded EMG from the FCR muscle in response to both the electrical stimulation and the brain commands during motor imagery. This model could capture the qualitative behavior of the H-reflex and how physiological variables change its waveform. Two mathematical models of the EMG signal (i.e., baseline EMG and H-reflex) were developed. These models were designed to simulate the EMG signal with respect to the intensity of contraction and electrical stimulation. Also, the effect of the brain descending pathways was considered with a parameter. We used the Hodgkin-Huxley (HH) and Morris-Lecar (ML) equations for the action potentials (APs) of motor neurons and muscle fibers, respectively. After processing the sensory signals in the spinal cord, the response pulses are transmitted from the spinal cord to the muscle. When the AP is generated, the spike train passes to the muscle fiber. Each muscle contains several motor units (MUs), each of which consists of a motor neuron and its innervated muscle fibers. Moreover, summation of the total activity of the muscle fibers within each MU forms its activity. Likewise, total muscle activity (i.e., EMG) is the summation of the activity of all MUs. The H-reflex and M-wave models were developed by applying electrical stimulation in the EMG model. Moreover, mean square error (MSE) for the model was 0.00027%, and Spearman`s correlation coefficient was 0.722 (p-value < 0.05).
{"title":"Modeling and Simulation of EMG Signal and H-Reflex in Healthy Human Subject","authors":"Seyyedeh Ensiyeh Hashemi, Mohammad Ali Ahmadi-Pajouh, Elham Shamsi","doi":"10.1109/ICBME.2018.8703535","DOIUrl":"https://doi.org/10.1109/ICBME.2018.8703535","url":null,"abstract":"Electromyography (EMG) is a signal representing the activity of skeletal muscles. Besides, H-reflex and M-wave are two responses to the electrical stimulation of the nerve, and they appear in EMG. In this paper, the purpose was to model the recorded EMG from the FCR muscle in response to both the electrical stimulation and the brain commands during motor imagery. This model could capture the qualitative behavior of the H-reflex and how physiological variables change its waveform. Two mathematical models of the EMG signal (i.e., baseline EMG and H-reflex) were developed. These models were designed to simulate the EMG signal with respect to the intensity of contraction and electrical stimulation. Also, the effect of the brain descending pathways was considered with a parameter. We used the Hodgkin-Huxley (HH) and Morris-Lecar (ML) equations for the action potentials (APs) of motor neurons and muscle fibers, respectively. After processing the sensory signals in the spinal cord, the response pulses are transmitted from the spinal cord to the muscle. When the AP is generated, the spike train passes to the muscle fiber. Each muscle contains several motor units (MUs), each of which consists of a motor neuron and its innervated muscle fibers. Moreover, summation of the total activity of the muscle fibers within each MU forms its activity. Likewise, total muscle activity (i.e., EMG) is the summation of the activity of all MUs. The H-reflex and M-wave models were developed by applying electrical stimulation in the EMG model. Moreover, mean square error (MSE) for the model was 0.00027%, and Spearman`s correlation coefficient was 0.722 (p-value < 0.05).","PeriodicalId":338286,"journal":{"name":"2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125003694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-02DOI: 10.1109/ICBME.2018.8703588
Elaheh Jooybar, M. Abdekhodaie, P. Dijkstra
Microgels are hydrophilic polymer matrix with high water content suitable for encapsulation and delivery of biomolecules. In this study, hyaluronic acid (HA) microgels were synthesized using a water in oil emulsion method. First, hyaluronic acid was modified with tyramine, and then the microemulsion was produced by homogenizing the polymer solution in isooctane as an oil phase. HA microdroplets were crosslinked via enzymatic method by addition of horseradish peroxidase (enzyme) and hydrogen peroxide, and stable microgels were produced in a mild crosslinking reaction. According to the results, larger microgels were achieved by increasing the initial polymer concentration. Two sample proteins, Bovine serum albumin (BSA) and lysozyme, were incorporated in the polymer network to investigate the encapsulation efficiency of the microgels. The results demonstrated that the proposed method has a high efficiency for protein encapsulation (> 70%). The release profiles showed that lysozyme, as a cationic protein, was released in a sustained manner over a period of two weeks. However, BSA, as a negatively charged protein, showed a faster release rate. The simple method of microgel fabrication, besides the sustained release of the encapsulated proteins, makes the HA microgels a promising vehicle for delivery of cationic proteins.
{"title":"Synthesis of Hyaluronic acid-Tyramine Microgels for Sustained Protein Release","authors":"Elaheh Jooybar, M. Abdekhodaie, P. Dijkstra","doi":"10.1109/ICBME.2018.8703588","DOIUrl":"https://doi.org/10.1109/ICBME.2018.8703588","url":null,"abstract":"Microgels are hydrophilic polymer matrix with high water content suitable for encapsulation and delivery of biomolecules. In this study, hyaluronic acid (HA) microgels were synthesized using a water in oil emulsion method. First, hyaluronic acid was modified with tyramine, and then the microemulsion was produced by homogenizing the polymer solution in isooctane as an oil phase. HA microdroplets were crosslinked via enzymatic method by addition of horseradish peroxidase (enzyme) and hydrogen peroxide, and stable microgels were produced in a mild crosslinking reaction. According to the results, larger microgels were achieved by increasing the initial polymer concentration. Two sample proteins, Bovine serum albumin (BSA) and lysozyme, were incorporated in the polymer network to investigate the encapsulation efficiency of the microgels. The results demonstrated that the proposed method has a high efficiency for protein encapsulation (> 70%). The release profiles showed that lysozyme, as a cationic protein, was released in a sustained manner over a period of two weeks. However, BSA, as a negatively charged protein, showed a faster release rate. The simple method of microgel fabrication, besides the sustained release of the encapsulated proteins, makes the HA microgels a promising vehicle for delivery of cationic proteins.","PeriodicalId":338286,"journal":{"name":"2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130825555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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