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2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)最新文献

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An Unsupervised and Supervised Combined Approach for White Blood Cells Segmentation 一种无监督与监督相结合的白细胞分割方法
Elnaz Mohammadi, M. Orooji
The white blood cell (WBC) segmentation and classification is a challenging task, due to the different shapes of the nucleus, cytoplasm and the number of lobes. The purpose of this paper is to provide a method for fast and accurate segmentation of leukocyte in smear images by a convolutional neural network (CNN) model and Gaussian Mixture Model (GMM) approach. The first step is the usage of white balance and selfdual multiscale morphological toggle (SMMT) to increase the contrast between the nucleus and cytoplasm. To segment, each WBC and corresponded nucleus and cytoplasm regions, a CNN model with 10 layers and GMM are used, respectively. In the postprocessing step, removing undesired objects by size, closing, and filling morphological operations are applied to each segment. The proposed method is validated on peripheral smear blood images in Cellavision dataset. This dataset contains 27 images which include different types of normal leukocytes. In order to evaluate the proposed method, the Dice coefficient, Jaccard and F1-score are used. The experimental results demonstrate the high accuracy for segmentation results of different types of WBC.
由于白细胞的核、细胞质和叶的形状不同,因此白细胞的分割和分类是一项具有挑战性的任务。本文的目的是通过卷积神经网络(CNN)模型和高斯混合模型(GMM)方法提供一种快速准确分割涂片图像中白细胞的方法。第一步是利用白平衡和自双尺度形态学切换(SMMT)来增强细胞核和细胞质之间的对比度。为了分割每个WBC和相应的细胞核和细胞质区域,分别使用10层的CNN模型和GMM。在后处理步骤中,对每个片段应用大小、闭合和填充形态学操作来去除不需要的对象。在Cellavision数据集的外周血涂片图像上验证了该方法的有效性。该数据集包含27张图像,其中包括不同类型的正常白细胞。为了评价所提出的方法,使用了骰子系数、Jaccard和f1分数。实验结果表明,该方法对不同类型WBC的分割结果具有较高的准确率。
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引用次数: 0
A Novel Auditory BCI for Spelling Persian Words 一种用于拼写波斯语单词的新型听觉脑机接口
Shayan Jalilpour, S. H. Sardouie
In this paper a novel auditory BCI paradigm based on P300 responses which are generated by auditory stimuli is proposed. In the proposed protocol, stimuli are different from each other and there is no need to repeat each single stimulus. Instead of that, a 30-word list containing different words as stimuli is played for the subject. Each letter is repeated in four different words of the list. Ensemble support vector machine and regularized linear discriminant analysis classifiers are used to evaluate the proposed protocol. The result of the offline classification of the P300 responses of one subject shows we can achieve accuracy and ITR of 88% and 3.51 bit/min for three iterations of the list (twelve repetitions of a letter).
本文提出了一种基于听觉刺激产生的P300反应的听觉脑机接口范式。在提出的方案中,刺激是不同的,不需要重复每个单一的刺激。取而代之的是,一个包含不同单词的30个单词列表作为刺激播放给受试者。每个字母在列表的四个不同单词中重复出现。使用集成支持向量机和正则化线性判别分析分类器对所提出的协议进行评估。对一个被试的P300反应进行离线分类的结果表明,我们对列表进行3次迭代(一个字母重复12次),准确率达到88%,ITR为3.51 bit/min。
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引用次数: 2
Enhanced Brain Inspired Model for Face Categorization Using Mutual Information Maximization 基于互信息最大化的增强脑启发人脸分类模型
Mohammad Jazlaeiyan, Sanaz Seyedin, S. A. Motamedi
Human visual system can robustly and simply recognize complex objects in cluttered natural scenes. So far, numerous computational models have been developed to mimic the computational process of this considerable system for machine vision systems. HMAX is known as one of the best computational models which have been inspired by hierarchical structure of the human visual cortex. During learning stage of the HMAX, a large number of small part of training images, called patches, are extracted at random positions. These patches are in various sizes and orientations. The random selection of patches, not only degrades the performance but also increases the computational complexity of HMAX-based object recognition systems. In this paper, we focus on this drawback and propose a new method based on information theory to select more relevant patches and remove redundant ones. The proposed method is developed for a face categorization task in which the purpose is to detect the presence or absence of faces in real world images. The performance of the proposed method has been evaluated on face image database CalTech101 and its recognition rate is superior to the original HMAX by more than 5%.
人类视觉系统可以在杂乱的自然场景中对复杂的物体进行简单、鲁棒的识别。到目前为止,已经开发了许多计算模型来模拟这个相当大的机器视觉系统的计算过程。HMAX是受人类视觉皮层层次结构启发而建立的最好的计算模型之一。在HMAX的学习阶段,在随机位置提取大量的训练图像的小部分,称为patch。这些补丁有不同的大小和方向。在基于hmax的目标识别系统中,补丁的随机选择不仅降低了性能,而且增加了计算复杂度。本文针对这一缺陷,提出了一种基于信息论的新方法来选择更相关的补丁并去除冗余的补丁。提出的方法是为人脸分类任务开发的,其目的是检测真实世界图像中人脸的存在或不存在。在人脸图像数据库CalTech101上对该方法的性能进行了评价,其识别率比原始HMAX提高了5%以上。
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引用次数: 2
A Low-Power Current-Mode Analog QRS-Detection Circuit for Wearable ECG Sensors 一种用于可穿戴式心电传感器的低功耗电流模式模拟qrs检测电路
Farnaz Morshedlou, N. Ravanshad, H. Rezaee-Dehsorkh
In this paper an ultra-low power current-mode analog circuit is proposed for detecting QRS complexes from the ECG signal. An accurate low-power operation is obtained by using a non-linear energy operator and designing all the transistors in subthreshold region. For improving the performance of the circuit, three filters with very-low cutoff frequencies are utilized which do not require large capacitors and so do not occupy large area. Two of the three filters are used for realizing onset detection method and the other is used for estimating a threshold which is required for QRS detection. Simulating over the entire MIT/BIH arrhythmia database shows the acceptable values of 98.69% for the average accuracy, 99.24% for the sensitivity and 99.38% for the positive prediction. The proposed circuit is implemented in 0.18 µm CMOS technology with a 1.8 V supply voltage. Using the proposed circuit, no analog-to-digital converter is required to be used which save a considerable portion of the power and the area. Consuming a 71 nW power, the proposed circuit is suitable for wearable and implantable ECG monitoring applications.
本文提出了一种超低功耗电流模模拟电路,用于从心电信号中检测QRS复合物。采用非线性能量算子,并将晶体管全部设计在亚阈值区域,实现了精确的低功耗运算。为了提高电路的性能,采用了三个截止频率极低的滤波器,不需要大的电容器,因此不占用大的面积。三个滤波器中的两个用于实现起始检测方法,另一个用于估计QRS检测所需的阈值。对整个MIT/BIH心律失常数据库的模拟显示,平均准确率为98.69%,灵敏度为99.24%,阳性预测为99.38%。该电路采用0.18µm CMOS技术,电源电压为1.8 V。使用该电路,无需使用模数转换器,从而节省了相当一部分功率和面积。该电路功耗为71 nW,适用于可穿戴式和植入式心电监测应用。
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引用次数: 6
ICBME 2018 Program
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引用次数: 0
Fuzzy Stochastic Petri Net with Uncertain Kinetic Parameters for Modeling Tumor-Immune System 动态参数不确定的模糊随机Petri网肿瘤免疫系统建模
Sajad Shafiekhani, S. Rahbar, Fahimeh Akbarian, A. Jafari
Uncertainty as inherent feature of Tumor-Immune system causes unpredictable behaviors of this complex network. Uncertainty of tumor-immune system is due to randomness in cell-cell interactions, vague, incomplete data, dynamic properties of tumor (including, e.g., extracellular ligands, mutation types, vascular status, phenotypic distribution) which are varying during time and patient-dependent properties. Fuzzy Stochastic Petri Net (FSPN) can capture this uncertainty that combine Stochastic Petri Net (SPN) with fuzzy sets. SPN model the dynamics of this complex network with regarding randomness in cell interactions and fuzzy sets consider fuzziness. FSPN of this study associate a fuzzy number instead of crisp number to kinetic parameter of SPN. Tumor-immune system of this study consider interactions of Tumor cells, Cytotoxic T lymphocytes (CTL) and Myeloid-derived suppressor cell as major component of system. CTLs are produced by immune activation of cytotoxic T cells and MDSCs augment in pathological situations such as cancer that acquire strong immunosuppressive activities. The dynamical behavior of tumor-immune system with regarding uncertain kinetic parameters is achieved by FSPN and the steady state behavior of the system with regarding fuzzy uncertain kinetic parameters is computed. The model simulates the dynamics of the cells in tumor escape and tumor elimination phases. FSPN proves that with increasing uncertainty of model parameters, the uncertainty of cell dynamics also increases. We showed that if the model kinetic parameters be a fuzzy number with a triangular membership function, the uncertainty interval of the cells is triangular in relation to the alpha-cuts.This method can be used for modeling and simulation of any biological network with uncertain information.
不确定性作为肿瘤免疫系统的固有特征,导致这个复杂网络的行为不可预测。肿瘤免疫系统的不确定性是由于细胞-细胞相互作用的随机性,模糊,不完整的数据,肿瘤的动态特性(包括,例如,细胞外配体,突变类型,血管状态,表型分布)随时间和患者依赖特性而变化。模糊随机Petri网(FSPN)将随机Petri网与模糊集相结合,可以捕捉到这种不确定性。SPN模型考虑了细胞间相互作用的随机性,模糊集考虑了模糊性。本研究的FSPN用模糊数代替清晰数来表示SPN的动力学参数。本研究的肿瘤免疫系统考虑肿瘤细胞、细胞毒性T淋巴细胞(CTL)和髓源性抑制细胞的相互作用作为系统的主要组成部分。ctl是由细胞毒性T细胞的免疫激活产生的,MDSCs在癌症等病理情况下增加,获得强大的免疫抑制活性。利用FSPN方法获得了动力学参数不确定时肿瘤免疫系统的动力学行为,并计算了动力学参数不确定时肿瘤免疫系统的稳态行为。该模型模拟了细胞在肿瘤逃逸和肿瘤消除阶段的动力学过程。FSPN证明,随着模型参数不确定性的增加,单元动力学的不确定性也随之增加。结果表明,如果模型动力学参数是一个具有三角形隶属函数的模糊数,则单元的不确定性区间相对于α -切割是三角形的。该方法可用于任何具有不确定信息的生物网络的建模和仿真。
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引用次数: 6
Mechanical Properties of Functionally Graded Biomaterials in Bone Replacement; Analytical and Numerical Solution 功能梯度生物材料在骨置换中的力学性能研究解析与数值解
M. Mahbod, M. Asgari
Porous biomaterials are known as one of the new materials which are widely used and especially appropriate for bone interfacing components. Besides providing a proper area for bone ingrowth, their mechanical properties mimic properties of bone. It has been entrenched that porous biomaterials can be produced considering defined representative volume elements (RVE) by recent developments in additive manufacturing. In this paper a novel functionally graded porous material is introduced based on a new RVE. In order to calculate the mechanical properties (elastic modulus, yield stress and Poisson's ratio), theoretical solutions are developed. Furthermore, a numerical investigation via ANSYS Workbench has been performed to validate the analytical solution. As the results show the obtained properties of the proposed structures are suitable for application of bone implant. Furthermore, the mechanical properties of each layer of structure have been calculated.
多孔生物材料是一种应用广泛的新型材料,尤其适用于骨界面材料。除了为骨骼生长提供合适的区域外,它们的机械性能也模仿了骨骼的性能。考虑到增材制造的最新发展,多孔生物材料可以通过定义的代表性体积元素(RVE)来生产。本文介绍了一种基于新型RVE的功能梯度多孔材料。为了计算其力学性能(弹性模量、屈服应力和泊松比),提出了理论解。在ANSYS Workbench上进行了数值研究,验证了解析解的正确性。结果表明,所获得的结构性能适合于骨种植体的应用。并对各层结构的力学性能进行了计算。
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引用次数: 2
Performance Evaluation of Deep Convolutional Maxout Neural Network in Speech Recognition 深度卷积Maxout神经网络在语音识别中的性能评价
Arash Dehghani, S. Seyyedsalehi
In this paper, various structures and methods of Deep Artificial Neural Networks (DNN) will be evaluated and compared for the purpose of continuous Persian speech recognition. One of the first models of neural networks used in speech recognition applications were fully connected Neural Networks (FCNNs) and, consequently, Deep Neural Networks (DNNs). Although these models have better performance compared to GMM / HMM models, they do not have the proper structure to model local speech information. Convolutional Neural Network (CNN) is a good option for modeling the local structure of biological signals, including speech signals. Another issue that Deep Artificial Neural Networks face, is the convergence of networks on training data. The main inhibitor of convergence is the presence of local minima in the process of training. Deep Neural Network Pre-training methods, despite a large amount of computing, are powerful tools for crossing the local minima. But the use of appropriate neuronal models in the network structure seems to be a better solution to this problem. The Rectified Linear Unit neuronal model and the Maxout model are the most suitable neuronal models presented to this date. Several experiments were carried out to evaluate the performance of the methods and structures mentioned. After verifying the proper functioning of these methods, a combination of all models was implemented on FARSDAT speech database for continuous speech recognition. The results obtained from the experiments show that the combined model (CMDNN) improves the performance of ANNs in speech recognition versus the pre-trained fully connected NNs with sigmoid neurons by about 3%.
本文将对深度人工神经网络(DNN)的各种结构和方法进行评估和比较,以实现连续波斯语语音识别。语音识别应用中最早使用的神经网络模型之一是全连接神经网络(fcnn),随后是深度神经网络(dnn)。尽管这些模型与GMM / HMM模型相比具有更好的性能,但它们没有适当的结构来建模局部语音信息。卷积神经网络(CNN)是对生物信号(包括语音信号)的局部结构进行建模的一个很好的选择。深度人工神经网络面临的另一个问题是网络在训练数据上的收敛。收敛的主要障碍是训练过程中存在的局部极小值。深度神经网络的预训练方法虽然计算量很大,但却是克服局部极小值的有力工具。但在网络结构中使用适当的神经元模型似乎是解决这个问题的更好方法。校正线性单元神经元模型和Maxout模型是目前提出的最合适的神经元模型。进行了几项实验来评估所述方法和结构的性能。在验证了这些方法的功能后,在FARSDAT语音数据库上实现了所有模型的组合,用于连续语音识别。实验结果表明,与带s型神经元的预训练全连接神经网络相比,CMDNN在语音识别方面的性能提高了约3%。
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引用次数: 2
Anisotropic material properties of human left common carotid artery using inverse finite element and analytical methods 人左颈总动脉各向异性材料特性的反演有限元及分析方法
Mohammad Behzady, H. Mohammadi, M. Farid
The focus of this study is to obtain the material properties of human common carotid artery (CCA). A hyper-elastic strain energy model is used to predict mechanical behavior of arterial wall from an inflation/deflation test on the human CCA intact wall. For this purpose, two methods are used in order to identify arterial material parameters: analytical and inverse finite element method. An optimization algorithm, based on aforementioned methods, is employed to find optimal parameters that have the best fitness with experimental data. The final outcome of the present study is to compare the reliability of aforementioned methods to identify material properties of modeling human CCA in FE problems.
本研究的重点是获得人颈总动脉(CCA)的材料特性。采用超弹性应变能模型对人动脉动脉壁进行胀/缩试验,预测了动脉壁的力学行为。为此,采用两种方法来确定动脉材料参数:解析法和逆有限元法。在上述方法的基础上,提出了一种优化算法,寻找与实验数据最适合的最优参数。本研究的最终结果是比较上述方法在确定有限元问题中模拟人类CCA的材料特性方面的可靠性。
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引用次数: 0
Numerical Simulation and Designing Artificial Neural Network for Water-Diamond Nanofluid Flow for Micro-Scale Cooling of Medical Equipment 医疗设备微尺度冷却用水-金刚石纳米流体流动的数值模拟及人工神经网络设计
M. Sepehrnia, Golnoush Abaei, Zahra Khosromirza, Faezeh RooghaniYazdi
Simultaneous using of MEMS (Micro Electro Mechanical Systems) and nanotechnology systems in the cooling of micro-scale electrical equipment has attracted researchers in recent years. In the present study, cooling of medical equipment with electronic board is discussed. For this purpose, water and water-diamond nanofluid with a volume fraction of 1%, 2%, 3% and 4% are used as a coolant of micro-scale cooling system. Coolants are pumped into heat sink at pressures of 5, 15, 25 and 35 kPa. The electronic chip on the board is embedded in the base plate of heat sink and generates uniform heat flux of 85kW/m2. The governing equations have been solved using finite volume method based on finite element. The results show that utilizing water-diamond nanofluid compared to water improves the cooling process so that utilizing water-diamond nanofluid with volume fraction of 4% improves the cooling process between 4.46% and 7.22%. Moreover, increasing pressure drop from 5 kPa to 35 kPa improves cooling indexes between 17.86% and 25.52%. Moreover, designing radial basis function artificial neural network shows good agreement between numerical simulation and predicted results.
近年来,微机电系统(MEMS)和纳米技术系统在微型电气设备冷却中的同步应用引起了研究人员的广泛关注。本文主要讨论了电子电路板医疗设备的冷却问题。为此,采用体积分数分别为1%、2%、3%和4%的水和水-金刚石纳米流体作为微尺度冷却系统的冷却剂。冷却剂以5,15,25和35kpa的压力泵入散热器。板上的电子芯片嵌入散热器底板内,产生均匀的热流密度85kW/m2。采用基于有限元的有限体积法求解了控制方程。结果表明:水-金刚石纳米流体与纯水相比,对冷却效果有明显改善,体积分数为4%的水-金刚石纳米流体对冷却效果的改善幅度在4.46% ~ 7.22%之间;当压降从5 kPa增加到35 kPa时,冷却指标的改善幅度在17.86% ~ 25.52%之间。设计径向基函数人工神经网络,数值模拟结果与预测结果吻合较好。
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引用次数: 4
期刊
2018 25th National and 3rd International Iranian Conference on Biomedical Engineering (ICBME)
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