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The Effect of Folate Status on Methotrexate Serum Level and Response in Children with Acute Lymphoblastic Leukemia 叶酸状态对急性淋巴细胞白血病患儿甲氨蝶呤血清水平及反应的影响
Pub Date : 2020-06-01 DOI: 10.33762/mjbu.2020.126734.1006
Dhuha Emad Omran, Nabeel Salih Ali, Jenan Ghalib
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引用次数: 0
Tachycardia-induced cardiomyopathy, a diagnosis forgotten in the real world: Review of case series. 心动过速引起的心肌病,一个在现实世界中被遗忘的诊断:病例系列回顾。
Pub Date : 2020-06-01 DOI: 10.33762/mjbu.2020.165391
Amar Alhamdi
Background: Left ventricular dysfunction induced by long-standing recurrent tachyarrhythmias, known as tachycardia-induced cardiomyopathy, is a reversible type of dilated cardiomyopathy and heart failure characterized by left ventricular failure that is usually recoverable once the tachyarrhythmia is well controlled by stabilizing the sinus rhythm or by heart rate control. Patients and methods: Twenty four patients with heart failure due to dilated cardiomyopathy and tachyarrhythmia were included. The arrhythmia and heart failure were both treated accordingly. The New York Heart Association’sfunctional class, left ventricular ejection fraction assessment and chest X-ray were done periodically to assess improvement. Results: Stabilization of the sinus rhythm was achieved in all patients. The NYHA class improved remarkably, from class III-IV to class I in all patients. The left ventricular ejection fraction rose remarkably from 20-30% to 4557%. The cardiac size remarkably improved radiologically. The symptoms of recurrent long-standing palpitation preceding the symptoms of dyspnea in heart failure are the first implication that arrhythmia is inducing the heart failure this was noticed in 20 patients. Conclusion: Tachycardia-induced cardiomyopathy is a reversible cause of heart failure. Controlling the arrhythmia recovers normal LV function.
背景:长期复发性心动过速引起的左心室功能障碍,又称心动过速性心肌病,是一种可逆性扩张型心肌病和心衰,以左心室衰竭为特征,一旦通过稳定窦性心律或心率控制好了心动过速,通常是可以恢复的。患者与方法:24例扩张型心肌病合并心动过速心力衰竭患者。心律失常和心力衰竭均予以相应治疗。定期进行纽约心脏协会功能分级、左心室射血分数评估和胸部x线检查以评估改善情况。结果:所有患者窦性心律均稳定。所有患者的NYHA分级均从III-IV级显著提高到I级。左室射血分数由20-30%显著升高至4557%。心脏大小在放射学上明显改善。在心力衰竭患者出现呼吸困难症状之前反复出现长期心悸的症状是心律失常诱发心力衰竭的第一个暗示,这在20例患者中被注意到。结论:心动过速引起的心肌病是心力衰竭的可逆原因。控制心律失常恢复正常左室功能。
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引用次数: 0
Epidemiological Features of COVID-19 Epidemic in Basrah-Southern Iraq-First Report 伊拉克巴士拉-南部地区新冠肺炎流行病学特征-首次报告
Pub Date : 2020-06-01 DOI: 10.33762/MJBU.2020.126943.1008
O. Habib, Abbas K AlKanan, A. Abed, Nihad K Mohammed
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引用次数: 14
Cisplatin & IV Etoposide combination in the treatment of advanced breast cancer pretreated with anthracyclines 顺铂与IV依托泊苷联合治疗蒽环类药物预处理的晚期乳腺癌
Pub Date : 2019-06-30 DOI: 10.33762/mjbu.2019.163352
A. Allami
Background: Aims of this study was to determine the benefit of cisplatin and i.v etoposide combination in treatment of advanced breast cancer (ABC) patients who were pretreated with anthracyclines, as an alternative to the newer, more expensive, and unavailable anticancer drugs like Taxanes, carboplatin, and gemcitabine. Patients and methods: The study was performed in the period from March 2010 to June 2016, 235 patients were given cisplatin 50mg/m and etoposide 100mg /m for 6 cycles. The patients were divided into 4 groups according to the site of metastasis (vertebral metastases, liver metastases, loco-regional metastases, and pleuro-pulmonary metastases). Results: Evaluation of treatment was considered on two levels: Whole 235 patient level, and patient-group level. On whole patient level: Response to Treatment was 65.1%, which is higher than similar responses in many other studies. While on patient-group level: response to treatment was highest in patients with vertebral secondaries 75.3%. There was drug toxicity in all groups of patients. Some patients did not continue the treatment protocol because of bad performance status, toxicity and death. Conclusion: In comparison with other regimes of chemotherapy cisplatin and i.v etoposide are still useful anticancer drugs in the management of advanced breast cancer.
背景:本研究的目的是确定顺铂和静脉依托泊苷联合治疗蒽环类药物预处理的晚期乳腺癌(ABC)患者的益处,作为更新、更昂贵、不可用的抗癌药物如紫杉烷、卡铂和吉西他滨的替代方案。患者和方法:研究于2010年3月至2016年6月进行,235例患者给予顺铂50mg/m,依托泊苷100mg /m, 6个周期。根据转移部位分为4组(椎体转移、肝转移、局部-区域转移、胸膜-肺转移)。结果:对治疗的评价分为两个层面:235例患者整体水平和患者组水平。在整个患者水平上:对治疗的反应为65.1%,高于许多其他研究的类似反应。而在患者组水平上:椎体继发性患者对治疗的反应最高,为75.3%。各组患者均有药物毒性。部分患者因治疗状态不佳、毒性和死亡而未能继续治疗。结论:与其他化疗方案相比,顺铂和依托泊苷仍是治疗晚期乳腺癌的有效药物。
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引用次数: 0
The effect of laparoscopic ovarian drilling on the serum levels of AMH, FSH, LH and Testosterone hormones, in patients with PCOS 腹腔镜卵巢钻孔对多囊卵巢综合征患者血清AMH、FSH、LH和睾酮水平的影响
Pub Date : 2019-06-30 DOI: 10.33762/MJBU.2019.163350
Ali F. Al-Assadi, D. Haroon, A. H. Al-Rubaye, Reem G Doshan
Objective: This study was performed to evaluate the effect of laparoscopic ovarian drilling on the serum levels of anti-Müllerian hormone(AMH), Follicle Stimulating hormone(FSH), Lutenizing hormone(LH) and testosterone hormones, in patients with PCOS. Methods: A prospective observational study carried out on 50 patients with PCOS who underwent LOD, as a treatment for anovulatory infertility between June 2015 and June 2016. This study was conducted in AL Basrah Hospital for maternity and children. We assessed the serum levels of anti-Müllerian hormone(AMH), Follicle Stimulating hormone(FSH), Lutenizing hormone(LH) and testosterone hormone (test.) one month before laparoscopic surgery, one day after and 3 months after the surgery. Results: Among 50 patients (2 patients were lost from follow up and they were excluded from the study), 31(64.6%) started to menstruate regularly and 26 (54.2%) ovulated spontaneously and 9(18.8%) of them conceive spontaneously after LOD within 3 months of doing the operation. The serum levels of hormons, before, one day after and 3 months after surgery, for AMH were 8.9 ± 3.5 ng/ml, 7.3 ± 2.9 ng/ml and 7.4 ± 2.1 ng/ml, (P value =0,000), respectively. For the FSH were 5.2 ± 1.8 IU/L, 6.5 ± 2.0 IU/L and 7.1 ± 1.9 IU/L, (p value = 0.000), respectively. For the LH were 10.2 ± 21 IU/L, 10.7 ± 4.5 IU/L and 7.2 ± 2.2 IU/L, (p value=0.000), respectively. For the testosterone levels were 1.16 ± 0.7 ng/ml, 0.44 ± 0.2 ng/ml and 0.34 ± 0.1ng/ml, (P value= 0.000), respectively. Conclusion: LOD operation is an effective treatment for infertile PCOS patient who are not responding to medical treatment (clomiphene citrate and gonadotrophine resistant cases or cases who can't offer the gonadotrophines). If it is done properly it will not affect the ovarian reserve. The resultant hormonal changes after the operation (decrease LH and testosterone) infavoure the continuation of pregnancy and lower the miscarriage rate. In our locality it represents a cost-effective and offered able alternative to medical treatment of PCOS.
目的:探讨腹腔镜卵巢钻孔术对PCOS患者血清抗勒氏激素(AMH)、促卵泡激素(FSH)、促黄体生成素(LH)和睾酮激素水平的影响。方法:对2015年6月至2016年6月期间接受LOD治疗无排卵性不孕的50例PCOS患者进行前瞻性观察研究。这项研究是在巴士拉妇幼医院进行的。术前1个月、术后1天、术后3个月分别测定患者血清抗勒氏激素(AMH)、促卵泡激素(FSH)、促黄体生成素(LH)、睾酮激素(test.)水平。结果:50例患者(随访丢失2例,未纳入本研究)中,31例(64.6%)月经开始规律,26例(54.2%)自行排卵,其中9例(18.8%)术后3个月内自行受孕。AMH组术前、术后1天、术后3个月血清激素水平分别为8.9±3.5 ng/ml、7.3±2.9 ng/ml、7.4±2.1 ng/ml, P值分别为0000。FSH分别为5.2±1.8 IU/L、6.5±2.0 IU/L和7.1±1.9 IU/L (p值= 0.000)。LH分别为10.2±21 IU/L、10.7±4.5 IU/L和7.2±2.2 IU/L (p值=0.000)。睾酮水平分别为(1.16±0.7)ng/ml、(0.44±0.2)ng/ml和(0.34±0.1)ng/ml (P值= 0.000)。结论:LOD手术是治疗药物治疗无效(克罗米芬和促性腺激素耐药或不能提供促性腺激素)的不孕性PCOS患者的有效方法。如果操作得当,它不会影响卵巢储备。术后产生的激素变化(LH和睾酮降低)有利于妊娠的延续,降低流产率。在我们当地,它代表了一种具有成本效益和可提供的多囊卵巢综合征药物治疗的替代方案。
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引用次数: 2
Surgical experience in treatment of achalasia cardia with minimal invasive surgery 微创手术治疗贲门失弛缓症的外科经验
Pub Date : 2019-06-30 DOI: 10.33762/mjbu.2019.163354
A. Yassin, F. Al-Gazgooz, Mazin H Al-Hawaz
Background: achalasia cardia is a motor disorder that result from absence of esophageal peristalsis combined with loss of relaxation of lower esophageal sphincter. Aims: To analyze the safety of laparoscopic Heller's myotomy with particular regard to the technical difficulties encountered, complications, the learning curve and outcome. Patients and methods: This study was done at Al Sader Teaching Hospital, Basrah Iraq in the period from February 2013 to June 2016. Thirty-two patients were included in the study of both gender and of different ages who were subjected to laparoscopic Heller's myotomy for achlasia cardia. They were observed regarding the development of operative and early post-operative complications, improvement of their symptoms, development of late post-operative complications and recurrence rate. Results: All patients underwent laparoscopic Heller's myotomy with Dor fundoplication except one patient had Toupet fundoplication. The mean operative time was 87 minutes and the median hospital stay was four days. Intraoperative complications include mucosal perforation in 3 patients, vagus nerve injury in 3 patients, and pleural perforation in 2 patients. Post-operative complications include atelectasis in 3 patients, pneumonia in 1 patient, GERD in 1 patient, post-operative leak in one patient and mortality in one patient. All patients improved regarding dysphagia (100%) and weight gain achieved in (91.3%), chest pain improved in (59%) and regurgitation improved in (84.6%) of the patients. Conclusion: Laparoscopic Heller's myotomy is safe and effective method for treatment of achalasia cardia.
背景:贲门失弛缓症是一种由食管蠕动缺失合并食管下括约肌松弛丧失引起的运动障碍。目的:分析腹腔镜下Heller肌切开术的安全性,特别是遇到的技术难点、并发症、学习曲线和结果。患者和方法:本研究于2013年2月至2016年6月在伊拉克巴士拉Al Sader教学医院完成。本研究包括32例不同性别和年龄的患者,他们接受了腹腔镜下的Heller肌切开术治疗贲门不全。观察两组患者手术及术后早期并发症的发生情况、症状的改善情况、术后晚期并发症的发生情况及复发率。结果:所有患者均行腹腔镜Heller肌切开术,除1例有Toupet底重复外。平均手术时间为87分钟,平均住院时间为4天。术中并发症包括粘膜穿孔3例,迷走神经损伤3例,胸膜穿孔2例。术后并发症包括肺不张3例,肺炎1例,胃反流1例,术后漏1例,死亡1例。所有患者的吞咽困难改善(100%),体重增加(91.3%),胸痛改善(59%),反流改善(84.6%)。结论:腹腔镜Heller肌切开术是治疗贲门失弛缓症安全有效的方法。
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引用次数: 0
Hand hygiene practice of health care workers in prevention of nosocomial infection in one hospital in Basrah 在巴士拉的一家医院,卫生保健工作者在预防医院感染方面的手卫生做法
Pub Date : 2019-06-30 DOI: 10.33762/mjbu.2019.163351
Alaa Mousa
Background: The hand hygiene plays an essential role in prevention as well as curing the nosocomial infectious disease. Physicians, nurses and laboratory persons are the major health care workers communicating with patients, could become the transporter in the cycle of infectious diseases. Objective: To evaluate the knowledge and practice of health care workers for hand hygiene in hospital wards and study the predisposing factors effecting the hand hygiene. Methods: A cross-sectional study carried out on doctors, nurses and laboratory men who worked in AlMawane Teaching Hospital in Basrah (Iraq). Questionnaire of hand hygiene for data collection was applied. Results: 401 health care workers were studied, The results showed moderate level of hand hygiene for doctors, nurses and laboratory persons (average score 3.97 + 0.6). Nurses had the highest level of hand hygiene. Perfect hand washing was found in 62%, compared with 56% for laboratory staff and 29% for physicians. Gender was insignificant in the practice of hand hygiene, while age, level of education, duration of service, training courses and vaccination against type B hepatitis had statistically significant impact on hand hygiene. Conclusion: The control of infection in hospitals goes through the care of hand hygiene in health workers, which need more attention. The current study revealed somewhat unacceptable level of knowledge and care of the cleanliness of the hands of doctors, nurses and laboratory persons. The need to develop the level of knowledge and practice by training programs and continuing medical education
背景:手卫生在预防和治疗院内感染性疾病中起着至关重要的作用。医生、护士和实验室人员是与患者交流的主要卫生保健工作者,可能成为传染病循环中的转运者。目的:了解医院病房医护人员手卫生知识和实践情况,探讨影响手卫生的因素。方法:对伊拉克巴士拉市AlMawane教学医院的医生、护士和实验室人员进行横断面研究。采用手卫生问卷进行数据收集。结果:对401名医护人员进行调查,结果显示医生、护士和实验室人员的手卫生水平一般(平均得分3.97 + 0.6)。护士的手卫生水平最高。62%的人完全洗手,相比之下,实验室工作人员洗手率为56%,医生洗手率为29%。性别对手卫生的影响不显著,而年龄、教育水平、服务年限、培训课程和乙型肝炎疫苗接种对手卫生的影响有统计学意义。结论:医院感染的控制主要通过医护人员的手卫生护理来实现,应引起重视。目前的研究显示,医生、护士和实验室人员对手部清洁的了解和护理程度有些不可接受。需要通过培训计划和继续医学教育来提高知识和实践水平
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引用次数: 1
A study on job satisfaction of family physicians in Basrah 巴士拉市家庭医生工作满意度调查
Pub Date : 2019-06-30 DOI: 10.33762/mjbu.2019.163348
R. K. Ali, O. Habib
Background: Job satisfaction is a reflection of interaction of the physicians and all the components of the surrounding environments. A high level of satisfaction is desirable and may contribute to better workers performance. Objectives: To explore the degree of satisfaction of family physicians in Basrah with their jobs. Methods: A cross-sectional study targeting all family physicians who were working in Basrah at the time of the study (2018) was carried out. A total of 67 out of 74 physicians were successfully interviewed according to a special questionnaire form that was prepared in the light of selected readings and guided by the researchers view on areas of interest. The data collection phase lasted for four months (AprilAugust 2018). Results: A good proportion (43.3%) of family physicians in Basrah were posted in places other than family medicine practice. The majority were young, females, and reasonably lived close to their work sites. Family physicians were very satisfied with the supervisors (95.5%), colleagues (97.0%) and clients (86.6%). They were also satisfied with their competence in handling their daily tasks and fairly satisfied with their postgraduate training and in-services training. They were very unsatisfied with their income, their work conditions in terms of amenities and staffing, with respect to specialty under two thirds (61.2%) expressed their satisfaction with their status as family physicians but 38.8% were not satisfied and this was reflected on their desire to quit to other specialty (55.2%). A big problem is the perception that the specialty is not respected by the public (85.1%), not respected by other clinical specialties (95.5%), not supported by mass media (95.5%), and the specialty is not optimally utilized (79.1%). However, 67.2% reported that the specialty improved care delivery at primary health care centres. Conclusions: Mostly family physicians were happy with competence required to handle tasks. Except for the overall work environment, participants denied to have adequate amenities. Most positive points were related to humanities. Most of negative points were related to income, recognition and amenities. They expressed negative views on all aspects of salary valuation and most of them wanted to change specialty.
背景:工作满意度是医生与周围环境各组成部分相互作用的反映。高水平的满意度是可取的,可能有助于更好的员工表现。目的:了解巴士拉市家庭医生对工作的满意度。方法:对研究(2018年)时在巴士拉工作的所有家庭医生进行横断面研究。根据一份特殊的问卷表格,74名医生中有67名成功接受了采访。这份表格是根据选定的阅读材料准备的,并以研究人员对感兴趣领域的看法为指导。数据收集阶段持续4个月(2018年4月至8月)。结果:巴士拉市有43.3%的家庭医生在家庭医学执业以外的地方工作。大多数是年轻的女性,住得离工作地点很近。家庭医生对督导(95.5%)、同事(97.0%)和客户(86.6%)的满意度较高。他们对自己处理日常工作的能力感到满意,对研究生培训和在职培训也相当满意。他们非常不满意他们的收入,他们的工作条件在设施和人员配备方面,就专业而言,不到三分之二(61.2%)表示满意他们作为家庭医生的身份,但38.8%表示不满意,这反映在他们希望辞职到其他专业(55.2%)。最大的问题是认为该专业不受公众尊重(85.1%),不受其他临床专业尊重(95.5%),不受大众媒体支持(95.5%),以及没有充分利用该专业(79.1%)。然而,67.2%的人报告说,该专业改善了初级卫生保健中心的保健服务。结论:大多数家庭医生对处理任务所需的能力感到满意。除了整体的工作环境,参与者否认有足够的设施。大多数积极的观点都与人文学科有关。大多数负面分数与收入、认可和舒适有关。他们对薪酬评估的各个方面都持否定态度,大多数人都想换专业。
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引用次数: 2
Socio-demographic characteristics of maternal deaths in Basrah or the period (2013-2017)
Pub Date : 2019-06-30 DOI: 10.33762/MJBU.2019.163349
R. Hilfi, Rajaa Ahmed Mahmoud, Nihad Q. Al Hamadi
Introduction and Background: In Iraq, and due to the decades of wars and sunctions that affected people’s accessibility to the health care services, maternal death was among the main health problems over the years. Thus, studying the factors influencing this important problem is a mandatory step for a better evidence based intervention in controlling the problem. Objective: To analyze the socio-demographic factors that influence maternal deaths in Basrah during the period 2013-2017. Methodology design: The study is an observational retrospective one included information collected from the medical records, death certificate and forensic medicine reports in addition to interviewing the family as needed. A total of 201 deaths were included in the study. Results: The study shows that maternal death rate in Basrah increased sharply during 2016 compared to that of 2013 with a highest rate in Shat Al-Arab and Al-Mudiana districts. Then, a sharp decrease was noticed in 2017 compared to 2016. Maternal mortality rates were found to be increasing with increasing women’s age with the highest rate among women above 40 years old. But no big difference between maternal death rates in urban and rural areas. (88.1%) of the study women died in hospital while 11.9% of them died outside the hospital Conclusions and recommendations: Maternal death is still a problem in Basrah in spite of the decline that occurred between (2016-2017) compared to the rates in 2013. Strengthening of maternal mortality monitoring system across all districts of Basrah governorate in addition to improving the quality of registering all pregnancy related information are the main recommendations of the study.
简介和背景:在伊拉克,由于几十年的战争和制裁影响了人们获得保健服务的机会,产妇死亡是多年来的主要健康问题之一。因此,研究影响这一重要问题的因素是更好地以证据为基础干预控制这一问题的必要步骤。目的:分析2013-2017年影响巴士拉孕产妇死亡的社会人口因素。方法设计:本研究为观察性回顾性研究,除必要时对家属进行访谈外,还包括从医疗记录、死亡证明和法医报告中收集的信息。该研究共包括201例死亡病例。结果:研究表明,2016年巴士拉的孕产妇死亡率与2013年相比急剧上升,其中沙阿拉区和穆戴纳区最高。然后,与2016年相比,2017年出现了急剧下降。产妇死亡率随着妇女年龄的增长而增加,其中40岁以上妇女的死亡率最高。但是城市和农村地区的产妇死亡率没有太大差别。结论和建议:与2013年相比,(2016-2017年)巴士拉的孕产妇死亡率有所下降,但孕产妇死亡仍然是一个问题。除了提高所有妊娠相关信息的登记质量外,研究报告的主要建议是加强巴士拉省所有地区的孕产妇死亡率监测系统。
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引用次数: 2
Assessment of dipping status of systemic blood pressure by 24 hour Ambulatory Blood Pressure Monitoring (ABPM) in patients with features of optic nerve head (disc) changes of Optic Neuropathy 视神经病变视神经头(盘)改变患者24小时动态血压监测(ABPM)评估全身血压下降状态
Pub Date : 2018-12-01 DOI: 10.33762/mjbu.2018.159466
K. A, A. A, Hani M. Aloubaidy A
Background: Optic neuropathy is a spectrum of disease of different etiology, and especially when associated with systemic disease like hypertension, where there is effect on auto regulation mechanism of the ocular perfusion. Aim: To see the blood pressure behavior and dipping status by 24 hour Ambulatory Blood Pressure Monitoring among patients who were diagnosed to have features of secondary optic neuropathy whether they were hypertensive or not. Methods: Ninety-four patients were included in a cross sectional study, and using specific exclusion criteria, 38 patients were having changes of optic neuropathy as diagnosed by optical coherence tomography, with 56 other patients as a control group. All were examined and investigated, and subjected to 24 hour Ambulatory Blood Pressure Monitoring test using specific device (CONTEC TM AUTOMATIC BP MONITER MODEL: ABPM50) and the data from the device were displayed to the computer for measurement and analysis. The dipping status was calculated manually using a specific formula. The data, then fed to SPSS software version 20 for statistical analysis. Results: There was no statistical significance for age, sex, BMI and other risk factors like hypertension, diabetes mellitus and dyslipidemia. Reverse or blunted response was common among hypertensive patients in both studied groups, but the P-value not significant. Conclusion: This study showed that there was no specific BP dipping pattern by ABPM in the studied patients with optic neuropathy in our locality.
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引用次数: 0
期刊
The Medical Journal of Basrah University
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