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1999 IEEE Ultrasonics Symposium. Proceedings. International Symposium (Cat. No.99CH37027)最新文献

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Selective destruction of contrast agent microspheres [drug delivery application] 造影剂微球的选择性破坏[给药应用]
A. Bouakaz, K. Shung
Recent studies have shown that ultrasound contrast agent may be used to deliver drugs. These drugs are directly released to the target tissue when the microspheres are exposed to high amplitude acoustic waves. The goal of this study was to investigate the destruction of microspheres by ultrasound waves to better understand the rates of transport and release that could provide the optimal spatial and temporal pattern for a drug delivery system. Experimental investigations have demonstrated that depending on the transmitted frequency, certain microsphere sizes within the same distribution are easier to rupture than others, and therefore can be selectively destroyed. These results were confirmed by measurements performed on filtered distributions. The study illustrates the potentials of ultrasound contrast agent for pharmacological applications. Different therapeutic compounds can be loaded within microspheres of different sizes and the release can be selectively activated from different regions in the size distribution.
最近的研究表明,超声造影剂可用于给药。当微球暴露在高振幅声波中时,这些药物直接释放到目标组织中。本研究的目的是研究超声波对微球的破坏,以更好地了解微球的运输和释放速度,从而为药物输送系统提供最佳的时空模式。实验研究表明,随着发射频率的不同,在同一分布范围内的某些微球尺寸比其他微球尺寸更容易破裂,因此可以选择性地破坏。这些结果通过对过滤分布的测量得到了证实。本研究说明了超声造影剂在药理学上的应用潜力。不同的治疗性化合物可以装载在不同大小的微球内,并且可以从大小分布的不同区域选择性地激活释放。
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引用次数: 5
Air-coupled nondestructive evaluation using micromachined ultrasonic transducers 利用微机械超声换能器进行空气耦合无损评价
S. Hansen, B. Mossawir, A. Sanli Ergun, F. Levent Degertekin, B. Khuri-Yakub
Nondestructive evaluation techniques which use conventional piezoelectric transducers typically require liquid coupling fluids to improve the impedance mismatch between piezoelectric materials and air. Air-coupled ultrasonic systems can eliminate this requirement if the dynamic range of the system is large enough such that the losses at the air-solid interfaces are tolerable. Capacitive micromachined ultrasonic transducers (cMUTs) have been shown to have more than 100 dB dynamic range when used in bistatic transmission mode. This dynamic range, along with the ability to transmit ultrasound efficiently into air, makes cMUTs ideally suited for air-coupled nondestructive evaluation applications. These transducers can be used either in through transmission experiments at normal incidence to the sample or to excite and detect guided waves in aluminum and composite plates. In this paper, we present results of a pitch-catch transmission system using cMUTs that achieves a dynamic range in excess of 100 dB. The pair of transducers is modeled with an equivalent electrical circuit which predicts the transmission system's insertion loss and dynamic range. We also demonstrate the feasibility of Lamb wave defect detection for one-sided nondestructive evaluation applications. A pair of cMUTs excites and detects the so mode in a 1.2 mm-thick aluminum plate with a received signal-to-noise ratio of 28 dB without signal averaging.
使用传统压电换能器的无损评估技术通常需要液体耦合流体来改善压电材料与空气之间的阻抗失配。空气耦合超声系统可以消除这一要求,如果系统的动态范围足够大,在气固界面的损失是可以容忍的。电容式微机械超声换能器(cMUTs)在双基地传输模式下具有超过100 dB的动态范围。这种动态范围,以及将超声波有效地传输到空气中的能力,使cMUTs非常适合空气耦合无损评估应用。这些换能器既可以用于正入射到样品的透透射实验,也可以用于激发和检测铝和复合材料板中的导波。在本文中,我们介绍了一个使用cmut实现超过100 dB动态范围的pitch-catch传输系统的结果。用等效电路对传感器进行了建模,预测了传输系统的插入损耗和动态范围。我们还证明了兰姆波缺陷检测在单面无损评价中的可行性。一对cMUTs在1.2 mm厚的铝板上激发和检测so模式,接收信噪比为28 dB,不进行信号平均。
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引用次数: 41
The evaluation of the /spl kappa/ factor for lossy and composite (Langevin-type) piezoelectric elements 有损和复合压电元件/spl kappa/系数的评估
N. Lamberti, A. Iula, R. Carotenuto, P. Di Rosa, M. Pappalardo
The most important property of a piezoelectric material for practical applications is its ability to convert electrical energy into mechanical energy and vice versa. As it is well known, the electromechanical coupling factor /spl kappa/ fully characterize this energy conversion. In a previous work we demonstrated that, like in static conditions, it is possible to define the /spl kappa/ factor also in dynamic situations as a ratio of energies. We also showed that the value of the /spl kappa/ factor computed in this way (/spl kappa//sub /spl omega//) coincides with the one obtained by using the empirical relation of the effective coupling factor /spl kappa//sub eff/. In this work we show that the proposed definition of the /spl kappa/ factor as ratio of energies can be extended to lossy elements, but, in this case, the k/sub eff/ does not give accurate estimation of the coupling factor. For composite Langevin-type structures, both /spl kappa/, and /spl kappa//sub eff/-fails.
压电材料在实际应用中最重要的特性是它能将电能转化为机械能,反之亦然。众所周知,机电耦合因子/spl / kappa/充分表征了这种能量转换。在之前的工作中,我们证明了,像在静态条件下一样,在动态情况下也可以将/spl kappa/因子定义为能量的比率。我们还发现,用这种方法计算的/spl kappa/因子(/spl kappa//sub /spl omega//)的值与利用有效耦合因子/spl kappa//sub //的经验关系得到的值是一致的。在这项工作中,我们证明了/spl kappa/因子作为能量比率的建议定义可以扩展到有耗元素,但是,在这种情况下,k/下标eff/不能给出耦合因子的准确估计。对于复合朗格万型结构,/spl kappa/和/spl kappa//sub / eff/-均失效。
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引用次数: 1
Techniques to determine the complex material constants of spherical and cylindrical ring resonators 确定球面和圆柱环形谐振器复杂材料常数的技术
R. Tasker, M. Lukacs, M. Sayer, S. Sherrit
Techniques to determine the dielectric, mechanical and piezoelectric losses for radial poled spherical, hemispherical, and thickness poled ring resonators were presented. The impedance equations of these resonators were derived from the theory of thin shells as discussed by Berlincourt, Curran and Jaffe. These have been generalized to include loss by making the material constants complex. Equations relating the complex frequency constants and complex material constants were also presented. The effect of measurement noise on results was examined by adding white noise on generated spectra. Analyzed material constants were found to be within 1 percent of the material constants used to generate the spectra. Applying a nonlinear regression technique was found to further reduce error in the determined constants. The radial poled cylinder was also discussed and methods to determine the complex material constants of this resonator were presented. The use of complex material constants with samples of these geometries was further demonstrated in the analysis of several ceramic PZT resonators.
介绍了径向极化球形、半球形和厚度极化环形谐振器的介电、机械和压电损耗测定方法。这些谐振器的阻抗方程是由Berlincourt, Curran和Jaffe讨论的薄壳理论推导出来的。这些已被推广到包括通过使材料常数复数的损失。给出了复频率常数和复材料常数的关系式。通过在生成的光谱中加入白噪声来检验测量噪声对结果的影响。被分析的材料常数被发现在1%以内的材料常数用于产生光谱。采用非线性回归技术可以进一步减小所确定常数的误差。讨论了径向极化圆柱谐振腔,并给出了确定该谐振腔复合材料常数的方法。在几个陶瓷PZT谐振器的分析中,进一步证明了复合材料常数与这些几何形状样品的使用。
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引用次数: 7
Acoustic diffusion wave in turbid media 混浊介质中的声扩散波
K. Sakai, O. Kanda, K. Yamamoto, K. Takagi
The acoustic diffusion wave in a turbid medium including randomly dispersed wave scatterers was observed. Ultrasonic wave at 15 MHz was modulated in amplitude and emitted into water suspension of polystyrene beads with 0.2 mm in diameter. Ray trace of the wave takes a random walk in the multiple scattering, and the acoustic energy flows in a diffusional manner. The spatial distribution of the oscillating acoustic energy was observed with an optical probe based on the Raman-Nath diffraction. The wavenumber and the spatial damping of the diffusion waves were determined at the modulation frequency of 4-20 kHz range. The results were well described by a modified diffusion theory including the effect of ultrasonic absorption. The diffusion constant and the lifetime of the acoustic energy were determined, which led to the transport mean free path and the ultrasonic absorption. The experiment was made at different volume fractions of the suspension, and l* and the lifetime were found to decrease with the number density of the scatterer.
观察了含随机分散散射体的浑浊介质中的声扩散波。将振幅为15 MHz的超声波调制后发射到直径为0.2 mm的聚苯乙烯微珠的水悬浮液中。声波的射线轨迹在多次散射中随机游走,声能以扩散方式流动。利用基于拉曼-纳特衍射的光学探针观察了振荡声波能量的空间分布。在4 ~ 20khz调制频率范围内测定了扩散波的波数和空间阻尼。用改进的扩散理论,包括超声吸收的影响,很好地描述了这一结果。测定了声能的扩散常数和寿命,得到了传递平均自由程和超声吸收。在不同体积分数的悬浮液中进行实验,发现l*和寿命随散射体数量密度的增加而减小。
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引用次数: 0
Nonlinear pulse calculations and data in water and a tissue mimic 非线性脉冲计算和数据在水和组织模拟
G. Wojcik, T. Szabo, J. Mould, L. Carcione, F. Clougherty
Nonlinear propagation is recognized as an important aspect of ultrasonic medical imaging. In particular, rigorous estimates of tissue bioeffects must include it. Regulatory standards rely on measurements in water to estimate effects in lossy tissue, but nonlinearity confuses the relationship. To help clarify the connection the authors complement laboratory hydrophone data with computer simulations of acoustic pulses in water and a tofu tissue mimic. A 2.25 MHz focused disk transducer is used instead of a rectangular medical array to facilitate modeling with a 2D pseudospectral solver that includes causal attenuation, inhomogeneity, multiple reflections, nonlinearity, and shock smoothing. Pressure scans near the transducer characterize the source and drive the wave solver. Measured and calculated nonlinear acoustic fields are compared over a 6 cm range in water and behind tofu cylinders. In the absence of high drive data the authors rely on nonlinear simulations to contrast water and tofu results, in anticipation of derating studies.
非线性传播是超声医学成像的一个重要方面。特别是,严格的组织生物效应估计必须包括它。监管标准依赖于水中的测量来估计对有损组织的影响,但非线性混淆了这种关系。为了帮助澄清两者之间的联系,作者用计算机模拟水中的声脉冲和豆腐组织模拟来补充实验室水听器数据。使用2.25 MHz聚焦磁盘换能器代替矩形医疗阵列,以方便使用包含因果衰减、非均匀性、多次反射、非线性和冲击平滑的二维伪光谱求解器进行建模。换能器附近的压力扫描表征源并驱动波解算器。测量和计算的非线性声场在6厘米范围内的水和豆腐圆柱后面进行了比较。在缺乏高驱动数据的情况下,作者依靠非线性模拟来对比水和豆腐的结果,以期望降额研究。
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引用次数: 20
Identification of ion species in electrolytic solutions using surface acoustic wave liquid flow sensing system based on new pattern recognition method 基于新模式识别方法的表面声波液流传感系统对电解溶液中离子种类的识别
J. Kondoh, Toshihisa Yamazaki, Y. Matsui, S. Shiokawa
The surface acoustic wave (SAW) on 36YX LiTaO3, the shear-horizontal mode (SH-SAW), can detect liquid properties. This paper describes the new method to identify and estimate components and concentration of ions in aqueous solutions by using a liquid-flow sensing system with the SH-SAW sensor without any selective organic films. The principle of the identification is based on the difference in transient responses. The proposed method includes a new technique for constituting the database of mixing ion solution from that of the single ion solutions.
36YX LiTaO3上的表面声波(SAW),剪切-水平模式(SH-SAW),可以检测液体性质。本文介绍了一种利用SH-SAW传感器的液流传感系统来识别和估计水溶液中离子成分和浓度的新方法,该系统不需要任何选择性有机膜。识别的原理是基于瞬态响应的差异。该方法包括一种由单离子溶液数据库组成混合离子溶液数据库的新技术。
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引用次数: 1
A novel, rapid method to measure the effective aperture of array elements 一种快速测量阵列元件有效孔径的新方法
E. Ledet, C. Zanelli
Effective aperture is a commonly used measure of the amount of acoustic or electrical crosstalk between elements in ultrasonic arrays. It is also important to assess element-to-element uniformity and quality of the separation between the elements. This parameter is obtained from the beam profile obtained by pulsing each individual element with a known excitation function. The traditional method, using hydrophones, presents many challenges that are overcome by the proposed method. Using a quantitative schlieren system, we imaged the acoustic burst from an array element. Automated processing allows determination of the average intensity over the burst at all angles (angular beam profile) and its width is used to determine the effective aperture for that element. Examples are presented for floating and purposefully coupled neighboring elements, and the results are in good agreement with those obtained with a hydrophone. The algorithm used for image analysis is also described.
有效孔径通常用于测量超声波阵列中元件之间的声学或电串扰量。评估元素之间的均匀性和元素之间分离的质量也很重要。这个参数是通过用已知的激励函数对每个单独的元件进行脉冲处理而得到的光束轮廓得到的。使用水听器的传统方法存在许多挑战,该方法克服了这些挑战。使用定量纹影系统,我们对来自阵列元件的声爆发进行了成像。自动化处理允许在所有角度(角光束剖面)上确定爆发的平均强度,其宽度用于确定该元件的有效孔径。文中给出了浮动和有目的耦合相邻单元的算例,结果与水听器的计算结果吻合较好。本文还介绍了用于图像分析的算法。
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引用次数: 8
The limitations of Snell's law in the design of ultrasound transducers 斯涅尔定律在超声换能器设计中的局限性
E. Kuhnicke
Because the refracted sound field of a finite beam extremely depends on the size and on the frequency of the generating element, Snell's law is not applicable to calculate the refraction angle of a finite beam. Approaches using plane reflection and transmission coefficient in connection with a discretization of the source into elementary point sources are more exact. This paper demonstrates that the application of plane reflection and transmission coefficients requires a point to point distance smaller than a half wavelength, in order to obtain an accurate sound field of the refracted beam.
由于有限波束的折射声场很大程度上取决于产生元件的大小和频率,所以斯涅尔定律不适用于计算有限波束的折射角。利用平面反射和透射系数将源离散化为基本点源的方法更为精确。本文论证了应用平面反射系数和透射系数时,为了获得精确的折射波束声场,需要点对点的距离小于半个波长。
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引用次数: 4
In vitro measurements of the lateral wave in human cortical bone 人皮质骨侧波的体外测量
E. Camus, M. Talmant, G. Berger, P. Laugier
Ultrasonic wave propagation in human cortical bone has been investigated in vitro using an axial transmission technique. Two quasi-point source elements, one transmitter and one receiver, were used to generate a wide ultrasonic beam including the longitudinal critical angle and to receive the signals radiated from the sample surface. Validation of the measuring technique was performed on test materials, followed by experiments on human cortical bones. Velocity measurements of the first arriving signal based on time-of-flight determinations were in agreement with reported values of longitudinal velocities for both test materials and bone specimens, and so did the experimental arrival times of the first arriving signal and ray arrival times of the lateral wave. The velocity in cortical bone ranged from 3600 to 4050 m.s/sup -1/. Our results strongly suggest that the first arriving signal corresponds to the lateral wave predicted by theory.
利用轴向传输技术研究了体外超声在人皮质骨中的传播。采用两个准点源单元,一个发射端和一个接收端,产生包含纵向临界角的宽超声波束,接收样品表面辐射的信号。在测试材料上验证了测量技术,然后在人类皮质骨上进行了实验。基于飞行时间测定的第一次到达信号的速度测量值与报道的测试材料和骨标本的纵速值一致,第一次到达信号的实验到达时间和横波的射线到达时间也是如此。骨皮质内的速度范围为3600 ~ 4050 m.s/sup -1/。我们的结果强烈表明,第一个到达的信号与理论预测的侧波相对应。
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引用次数: 0
期刊
1999 IEEE Ultrasonics Symposium. Proceedings. International Symposium (Cat. No.99CH37027)
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