Ruchi J. Shah, Y. Marfatia, Keshav Jayeshbhai Shah, R. Shah
Long-term diabetes can lead to complications including diabetic macro- and microangiopathy. Capillaroscopy is a non-invasive method to evaluate capillary microvasculature which can be used to demonstrate changes in capillary microarchitecture noted in diabetic microangiopathy. The objective of this study was to study cutaneous manifestations of diabetes mellitus (DM), nailfold capillaroscopic changes due to diabetic microangiopathy, as well as to determine association between nailfold capillaroscopy (NFC) and cutaneous manifestations due to DM. Two hundred cases suffering from type 2 DM having cutaneous manifestations were enrolled in the study. Patients with autoimmune diseases, smokers and on long-term corticosteroids were excluded from the study. Detailed history was taken and the cutaneous manifestations related to type 2 DM were noted. NFC was done for all ten fingers of all patients. Additional investigations including HbA1c, urine microalbumin and fasting lipid profile were performed. Out of 200 cases, 88 showed positive findings on NFC with the most common finding being altered tortuosity (seen in 85.2% cases). Chi-square test was done to demonstrate association between duration of DM and NFC which showed P-value of 0.027, which is statistically significant. Of the cases having nailfold capillaroscopic findings, 69/88 (78.4%) were found to have elevated HbA1C levels, 57/88 (57.9%) were found to have changes of diabetic retinopathy and 56/88 (63.6%) were found to have changes of diabetic nephropathy. NFC can provide key data for determination of vascular damage in diabetic patients and, thus, allows evaluation of progression of the disease making this technique a potential future utility in microvascular disease evaluation.
{"title":"Study of Cutaneous Manifestations and Nail fold Capillaroscopic findings in Diabetes Mellitus and their correlation with Diabetic Retinopathy and Nephropathy- A Cross Sectional Observational Study","authors":"Ruchi J. Shah, Y. Marfatia, Keshav Jayeshbhai Shah, R. Shah","doi":"10.25259/ijpgd_37_2022","DOIUrl":"https://doi.org/10.25259/ijpgd_37_2022","url":null,"abstract":"\u0000\u0000Long-term diabetes can lead to complications including diabetic macro- and microangiopathy. Capillaroscopy is a non-invasive method to evaluate capillary microvasculature which can be used to demonstrate changes in capillary microarchitecture noted in diabetic microangiopathy. The objective of this study was to study cutaneous manifestations of diabetes mellitus (DM), nailfold capillaroscopic changes due to diabetic microangiopathy, as well as to determine association between nailfold capillaroscopy (NFC) and cutaneous manifestations due to DM.\u0000\u0000\u0000\u0000Two hundred cases suffering from type 2 DM having cutaneous manifestations were enrolled in the study. Patients with autoimmune diseases, smokers and on long-term corticosteroids were excluded from the study. Detailed history was taken and the cutaneous manifestations related to type 2 DM were noted. NFC was done for all ten fingers of all patients. Additional investigations including HbA1c, urine microalbumin and fasting lipid profile were performed.\u0000\u0000\u0000\u0000Out of 200 cases, 88 showed positive findings on NFC with the most common finding being altered tortuosity (seen in 85.2% cases). Chi-square test was done to demonstrate association between duration of DM and NFC which showed P-value of 0.027, which is statistically significant. Of the cases having nailfold capillaroscopic findings, 69/88 (78.4%) were found to have elevated HbA1C levels, 57/88 (57.9%) were found to have changes of diabetic retinopathy and 56/88 (63.6%) were found to have changes of diabetic nephropathy.\u0000\u0000\u0000\u0000NFC can provide key data for determination of vascular damage in diabetic patients and, thus, allows evaluation of progression of the disease making this technique a potential future utility in microvascular disease evaluation.\u0000","PeriodicalId":339918,"journal":{"name":"Indian Journal of Postgraduate Dermatology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132981512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nevoid acanthosis nigricans is a rare variant of acanthosis nigricans that may develop at birth or before puberty. An 18-year-old boy with a lean built presented with asymptomatic hyperpigmented lesion on the left lateral aspect of the trunk since 15 years of age. There was no systemic involvement. The diagnosis of unilateral nevoid acanthosis nigricans variant was made which was confirmed by dermoscopy and histopathology.
{"title":"Nevoid Acanthosis Nigricans - A rare case and successful treatment using fractional CO2 laser","authors":"M. Gautam, Sejal Kumar, Vedant Ghuse","doi":"10.25259/ijpgd_42_2022","DOIUrl":"https://doi.org/10.25259/ijpgd_42_2022","url":null,"abstract":"Nevoid acanthosis nigricans is a rare variant of acanthosis nigricans that may develop at birth or before puberty. An 18-year-old boy with a lean built presented with asymptomatic hyperpigmented lesion on the left lateral aspect of the trunk since 15 years of age. There was no systemic involvement. The diagnosis of unilateral nevoid acanthosis nigricans variant was made which was confirmed by dermoscopy and histopathology.","PeriodicalId":339918,"journal":{"name":"Indian Journal of Postgraduate Dermatology","volume":"181 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115561186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. T. P. B. Singh, Nibedita Dixit, Liza Mohapatra, M. Nayak
{"title":"Dermoscopic Manoeuvre to Diagnose Spider Angiomas","authors":"S. T. P. B. Singh, Nibedita Dixit, Liza Mohapatra, M. Nayak","doi":"10.25259/ijpgd_26_2022","DOIUrl":"https://doi.org/10.25259/ijpgd_26_2022","url":null,"abstract":"","PeriodicalId":339918,"journal":{"name":"Indian Journal of Postgraduate Dermatology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116790688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IJPGD: The journey so far and the path ahead","authors":"Y. Marfatia, R. Sarkar, A. Khurana","doi":"10.25259/ijpgd_9_2023","DOIUrl":"https://doi.org/10.25259/ijpgd_9_2023","url":null,"abstract":"","PeriodicalId":339918,"journal":{"name":"Indian Journal of Postgraduate Dermatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132699923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leprosy is a chronic infectious granulomatous disorder caused by Mycobacterium leprae, chiefly affecting skin and peripheral nerves. It is the only known bacteria to infect nerves. Clinical diagnosis of leprosy is made when any of the three cardinal signs defined by the World Health Organisation is present. However, leprosy has varied presentations necessitating laboratory diagnostic methods for diagnosis as well as treatment initiation and monitoring. Slit-skin smears and histopathology form the basic diagnostics of maximum utility, while neurological studies, cytology and imaging have significant specific roles. Novel molecular and serological tests are of value in the diagnosis of early, indeterminate, and paucibacillary leprosy, and for screening of asymptomatic contacts. Molecular methods have in addition found an important place in diagnosis of drug resistance in leprosy.
{"title":"Diagnosis of Leprosy: Current Updates and Future Directions","authors":"Savitha Bathula, A. Khurana, I. Singh","doi":"10.25259/ijpgd_36_2022","DOIUrl":"https://doi.org/10.25259/ijpgd_36_2022","url":null,"abstract":"Leprosy is a chronic infectious granulomatous disorder caused by Mycobacterium leprae, chiefly affecting skin and peripheral nerves. It is the only known bacteria to infect nerves. Clinical diagnosis of leprosy is made when any of the three cardinal signs defined by the World Health Organisation is present. However, leprosy has varied presentations necessitating laboratory diagnostic methods for diagnosis as well as treatment initiation and monitoring. Slit-skin smears and histopathology form the basic diagnostics of maximum utility, while neurological studies, cytology and imaging have significant specific roles. Novel molecular and serological tests are of value in the diagnosis of early, indeterminate, and paucibacillary leprosy, and for screening of asymptomatic contacts. Molecular methods have in addition found an important place in diagnosis of drug resistance in leprosy.","PeriodicalId":339918,"journal":{"name":"Indian Journal of Postgraduate Dermatology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116827529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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