Objectives: Because developing a new drug is a lengthy process, the drugs used safely were tried to be repur-posed for COVID-19 treatment. In this retrospective study, it was aimed to investigate the effects of famotidine on the mortality, need for invasive mechanical ventilation, and the severity of the disease in patients diagnosed with COVID-19 in the intensive care unit (ICU) by regarding laboratory results. Methods: Data of patients treated in the ICU due to COVID-19 were retrospectively analyzed. The patients us-ing famotidine were named Group F (n=30), and the patients not using it were named Group C (n=29). Invasive mechanical ventilation needs, 30-day mortality, intubation time, lymphocyte, ferritin, C-reactive protein (CRP), D-dimer, fibrinogen, and procalcitonin values were compared between groups. Mann–Whitney U-test and repeated measures ANOVA tests were used as statistical methods. Results: There was no statistical difference between the groups in terms of the need for invasive mechanical ventilation, 30-day mortality, length of stay in the ICU, and intubation time. In the laboratory, lymphocyte count, ferritin and D-dimer values were similar between the groups, while CRP was higher in Group F until the 14 th day. Fibrinogen and procalcitonin values were lower in Group F. Conclusion: Famotidine treatment did not have a positive effect on the need for invasive mechanical ventilation and 30-day mortality in COVID-19 patients followed in the ICU. However, we think that it may have positive effects on coagulation, against the inflammation process and secondary infections.
{"title":"Effects of Famotidine on COVID-19 Patients in Intensive Care Unit: A Retrospective Clinical Trial","authors":"Senem Koruk","doi":"10.14744/bmj.2023.77044","DOIUrl":"https://doi.org/10.14744/bmj.2023.77044","url":null,"abstract":"Objectives: Because developing a new drug is a lengthy process, the drugs used safely were tried to be repur-posed for COVID-19 treatment. In this retrospective study, it was aimed to investigate the effects of famotidine on the mortality, need for invasive mechanical ventilation, and the severity of the disease in patients diagnosed with COVID-19 in the intensive care unit (ICU) by regarding laboratory results. Methods: Data of patients treated in the ICU due to COVID-19 were retrospectively analyzed. The patients us-ing famotidine were named Group F (n=30), and the patients not using it were named Group C (n=29). Invasive mechanical ventilation needs, 30-day mortality, intubation time, lymphocyte, ferritin, C-reactive protein (CRP), D-dimer, fibrinogen, and procalcitonin values were compared between groups. Mann–Whitney U-test and repeated measures ANOVA tests were used as statistical methods. Results: There was no statistical difference between the groups in terms of the need for invasive mechanical ventilation, 30-day mortality, length of stay in the ICU, and intubation time. In the laboratory, lymphocyte count, ferritin and D-dimer values were similar between the groups, while CRP was higher in Group F until the 14 th day. Fibrinogen and procalcitonin values were lower in Group F. Conclusion: Famotidine treatment did not have a positive effect on the need for invasive mechanical ventilation and 30-day mortality in COVID-19 patients followed in the ICU. However, we think that it may have positive effects on coagulation, against the inflammation process and secondary infections.","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of clinical observation scales in determining mortality for cerebrovascular diseases","authors":"Isil Kalyoncu Aslan","doi":"10.14744/bmj.2022.24855","DOIUrl":"https://doi.org/10.14744/bmj.2022.24855","url":null,"abstract":"","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67320957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is Long Proximal Femoral Nail Antirotation Superior To Proximal Femoral Locking Compression Plate In Reverse Oblique Intertrochanteric Fractures?","authors":"A. O. Akpolat","doi":"10.14744/bmj.2022.38358","DOIUrl":"https://doi.org/10.14744/bmj.2022.38358","url":null,"abstract":"","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67321862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The aim of this study is to reveal the diagnostic value of abdominal computed tomography (CT) in patients with suspected acute appendicitis according to their histopathological diagnosis and who were operated on after double contrast abdominal CT. Methods: The data of patients who were admitted to Bakirkoy Dr. Sadi Konuk Research and Training Hospital Emergency Medicine Clinic between March 01, 2009, and March 01, 2011, due to abdominal pain and were operated on with a clinical diagnosis of the acute appendicitis have been reviewed. The case group consisted of 111 patients who underwent preoperative double-contrast abdominal CT scans; the control group consisted of 50 randomly selected patients who were operated on without abdominal CT scans. Results: In this study, 57.1% of patients were male, 42.9% of patients were female, and the mean age of patients was 38.90±16.38 years. There was no significant difference between the groups in terms of gender, age, symptoms, body temperature, abdominal physical examination, white blood cells, complete urinalysis results, or Alvarado score (p>0.05). The diagnostic difference between ultrasonography (USG) and CT was found to be statistically significant in patients who were histopathologically diagnosed with appendicitis compared to those who did not. While the sensitivity of USG was 35.71%, specificity 85.71%, positive predictive value (PPV) 90%, and negative predictive value (NPV) 27.02%, the sensitivity of CT was 60.46%, specificity 92%, PPV 92.85%, and NPV 40.35% was found in the diagnosis of acute appendicitis. Conclusion: CT is one of the essential methods that can be used in the diagnosis of acute appendicitis in the emergency department and it can reduce unnecessary laparotomies. Acute appendicitis can be diagnosed by clinical examination and USG in the emergency department, but the value of CT was higher in patients who could not be diagnosed with acute appendicitis by USG.
{"title":"Prediagnostic Clinical Evaluations and Double Contrast Computed Tomography in Suspected Acute Appendicitis","authors":"Yılmaz Aydın","doi":"10.14744/bmj.2023.72621","DOIUrl":"https://doi.org/10.14744/bmj.2023.72621","url":null,"abstract":"Objectives: The aim of this study is to reveal the diagnostic value of abdominal computed tomography (CT) in patients with suspected acute appendicitis according to their histopathological diagnosis and who were operated on after double contrast abdominal CT. Methods: The data of patients who were admitted to Bakirkoy Dr. Sadi Konuk Research and Training Hospital Emergency Medicine Clinic between March 01, 2009, and March 01, 2011, due to abdominal pain and were operated on with a clinical diagnosis of the acute appendicitis have been reviewed. The case group consisted of 111 patients who underwent preoperative double-contrast abdominal CT scans; the control group consisted of 50 randomly selected patients who were operated on without abdominal CT scans. Results: In this study, 57.1% of patients were male, 42.9% of patients were female, and the mean age of patients was 38.90±16.38 years. There was no significant difference between the groups in terms of gender, age, symptoms, body temperature, abdominal physical examination, white blood cells, complete urinalysis results, or Alvarado score (p>0.05). The diagnostic difference between ultrasonography (USG) and CT was found to be statistically significant in patients who were histopathologically diagnosed with appendicitis compared to those who did not. While the sensitivity of USG was 35.71%, specificity 85.71%, positive predictive value (PPV) 90%, and negative predictive value (NPV) 27.02%, the sensitivity of CT was 60.46%, specificity 92%, PPV 92.85%, and NPV 40.35% was found in the diagnosis of acute appendicitis. Conclusion: CT is one of the essential methods that can be used in the diagnosis of acute appendicitis in the emergency department and it can reduce unnecessary laparotomies. Acute appendicitis can be diagnosed by clinical examination and USG in the emergency department, but the value of CT was higher in patients who could not be diagnosed with acute appendicitis by USG.","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135316872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spuriously high levels in a patient after total parathyroidectomy with forearm auto-transplantation","authors":"Özge KAMA BAŞCI","doi":"10.14744/bmj.2022.72602","DOIUrl":"https://doi.org/10.14744/bmj.2022.72602","url":null,"abstract":"","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67322421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Coronavirus Disease 2019 on Retinal Thickness: A Prospective Study COVID-19 and Retina","authors":"Okşan Alpoğan","doi":"10.14744/bmj.2023.49344","DOIUrl":"https://doi.org/10.14744/bmj.2023.49344","url":null,"abstract":"","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135260826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety Surgery Control List in International Patient Safety Targets","authors":"Zeliha Berke Aktar","doi":"10.14744/bmj.2023.38257","DOIUrl":"https://doi.org/10.14744/bmj.2023.38257","url":null,"abstract":"","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135261039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Since lung cancer is the most deadly cancer in the world, developments regarding immune control points and molecules affecting these points have increased. The positive effects of immunotherapy treatments affecting the PD-1/programmed death receptor ligand-1(PD-L1) immune checkpoint on prognosis have drawn attention to these immunocheckpoints. While immunotherapy studies developed for the PD-1 pathway continue rapidly, the aim of this study is to investigate whether PD-L1 level can be used as a prognostic marker in non-small-cell lung cancer independent of immunotherapy. Methods: 115 patients admitted to our center between January 01, 2016, and January 01, 2018 and diagnosed with non-small-cell lung cancer were retrospectively analyzed. The files of all patients were scanned in detail and their pathological data were confirmed. Demographic data of the patients included in the study, pathological diagnosis methods, treatment information about the disease, and past medical histories of the patients were recorded with reference to the hospital database. Results: The patients with PD-L1 <50% were considered the negative group (NG), and the group with a PD-L1 value of 50% or more was considered the positive group (PG). There were 27 patients in the NG and 11 patients in the PG. It was determined that 21 (67.8%) of 27 NG patients and 3 (21.3%) of 11 PG patients died. In total, 24 (73.2%) of 38 patients were found to have died. While the mean survival in the NG was 10.81 months, the mean survival in the PG was 28.54 months. Mean survival in the PG was statistically significant (p=0.046). Conclusion: PD-L1 expression was found to be a positive predictive value in Stage 4 non-small-cell lung cancer. Our study differs from other studies in that it excluded epidermal growth factor receptor, anaplastic lymphoma kinase, and ROS mutations. To determine the relationship of PD-L1 with prognosis more clearly, there is a need for randomized, prospective studies with larger patient groups that exclude target mutations and are independent of immunotherapy and targeted therapies.
{"title":"Prognostic Significance of PD-L1 Expression in Stage 4 Non-Small-Cell Lung Cancer","authors":"Şeyma Özden","doi":"10.14744/bmj.2023.24572","DOIUrl":"https://doi.org/10.14744/bmj.2023.24572","url":null,"abstract":"Objectives: Since lung cancer is the most deadly cancer in the world, developments regarding immune control points and molecules affecting these points have increased. The positive effects of immunotherapy treatments affecting the PD-1/programmed death receptor ligand-1(PD-L1) immune checkpoint on prognosis have drawn attention to these immunocheckpoints. While immunotherapy studies developed for the PD-1 pathway continue rapidly, the aim of this study is to investigate whether PD-L1 level can be used as a prognostic marker in non-small-cell lung cancer independent of immunotherapy. Methods: 115 patients admitted to our center between January 01, 2016, and January 01, 2018 and diagnosed with non-small-cell lung cancer were retrospectively analyzed. The files of all patients were scanned in detail and their pathological data were confirmed. Demographic data of the patients included in the study, pathological diagnosis methods, treatment information about the disease, and past medical histories of the patients were recorded with reference to the hospital database. Results: The patients with PD-L1 <50% were considered the negative group (NG), and the group with a PD-L1 value of 50% or more was considered the positive group (PG). There were 27 patients in the NG and 11 patients in the PG. It was determined that 21 (67.8%) of 27 NG patients and 3 (21.3%) of 11 PG patients died. In total, 24 (73.2%) of 38 patients were found to have died. While the mean survival in the NG was 10.81 months, the mean survival in the PG was 28.54 months. Mean survival in the PG was statistically significant (p=0.046). Conclusion: PD-L1 expression was found to be a positive predictive value in Stage 4 non-small-cell lung cancer. Our study differs from other studies in that it excluded epidermal growth factor receptor, anaplastic lymphoma kinase, and ROS mutations. To determine the relationship of PD-L1 with prognosis more clearly, there is a need for randomized, prospective studies with larger patient groups that exclude target mutations and are independent of immunotherapy and targeted therapies.","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135312101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: It has been reported that restless legs syndrome (RLS) is seen at a higher rate in obese and diabetic patients than in the normal population. In this study, we aimed to investigate obesity, insulin resistance (IR), and visceral adiposity index (VAI) rates and the relationship of these values with the severity of RLS in individuals without a diagnosis other than RLS. Methods: This prospective study was conducted with 149 patients diagnosed with RLS and 105 healthy volunteers. Patients were evaluated with the RLS Severity Rating Scale and classified according to symptom severity. Demographic characteristics of the patients, iron, inflammation, and blood cholesterol levels were measured, and body mass indexes (BMI), VAI, and IR values were calculated. Results: A majority (64.8%) of the patients were female and the symptoms were severe in 35.6%. C-reactive protein, BMI, and VAI levels were found to be significantly higher in patients with RLS than in the control group (p<0.001). The number of IR and obese patients in the RLS group was significantly higher than the control group. In patients with severe RLS symptoms, the VAI levels and the ratio of those with IR were significantly higher than in those with mild symptoms (p=0.006, p=0.001). Conclusion: It was shown that patients with RLS had a higher rate of IR, VAI, and obesity compared to the control group. Although VAI and IR were significantly higher in patients with severe RLS symptoms, we did not find a relationship between obesity and disease severity. VAI and IR parameters could be useful markers for assessing the risk of developing RLS and disease prognosis.
{"title":"Visceral Adiposity Index and Insulin Resistance in Restless Legs Syndrome","authors":"Gülhan Sarıçam","doi":"10.14744/bmj.2023.94834","DOIUrl":"https://doi.org/10.14744/bmj.2023.94834","url":null,"abstract":"Objectives: It has been reported that restless legs syndrome (RLS) is seen at a higher rate in obese and diabetic patients than in the normal population. In this study, we aimed to investigate obesity, insulin resistance (IR), and visceral adiposity index (VAI) rates and the relationship of these values with the severity of RLS in individuals without a diagnosis other than RLS. Methods: This prospective study was conducted with 149 patients diagnosed with RLS and 105 healthy volunteers. Patients were evaluated with the RLS Severity Rating Scale and classified according to symptom severity. Demographic characteristics of the patients, iron, inflammation, and blood cholesterol levels were measured, and body mass indexes (BMI), VAI, and IR values were calculated. Results: A majority (64.8%) of the patients were female and the symptoms were severe in 35.6%. C-reactive protein, BMI, and VAI levels were found to be significantly higher in patients with RLS than in the control group (p<0.001). The number of IR and obese patients in the RLS group was significantly higher than the control group. In patients with severe RLS symptoms, the VAI levels and the ratio of those with IR were significantly higher than in those with mild symptoms (p=0.006, p=0.001). Conclusion: It was shown that patients with RLS had a higher rate of IR, VAI, and obesity compared to the control group. Although VAI and IR were significantly higher in patients with severe RLS symptoms, we did not find a relationship between obesity and disease severity. VAI and IR parameters could be useful markers for assessing the risk of developing RLS and disease prognosis.","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Posterior circulation ischemia syndrome is a common feature of the poor blood flow to the posterior cerebral regions which is generally caused by atherosclerotic involvement of vertebral arteries (VA). However, the risk factors for VA atherosclerosis remain largely unknown. Lipoprotein (a) (Lp(a)), a modified low-density lipoprotein, has been implicated as a risk factor for coronary and peripheral artery disease. Our aim was to investigate the possible association of Lp(a) with low vertebral artery flow, a marker representing VA atherosclerosis. Methods: An institutional registry database was used for the present study. A complete dataset, including Doppler ultrasound imaging of the carotid and VA was available in 135 of 718 cases, and these cases were included in the analysis. Results: 29 (21.1%) patients had Lp(a)>30 mg/dL, and total VA flow in these patients was significantly less than in patients with Lp(a)<30 mg/dL (243.0 mL/min [212.0–276.0] vs. 256.0 mL/min [230.0–307.0], p=0.03). Lp(a) had a significant correlation with VA flow (r=−0.24, p=0.004), and this association remained significant after adjustment for other lipid parameters (β=−0.244, p=0.004) and demographic variables (β=−0.225, p=0.007). Furthermore, the correlation between Lp(a) and VA flow was stronger in 11 patients with evidence of carotid atherosclerosis on DUS (r=−0.74, p<0.001). Conclusion:
{"title":"Lipoprotein (a) Concentration is Inversely Related with Vertebral Arterial Flow","authors":"Abdulrahman Naser","doi":"10.14744/bmj.2023.36744","DOIUrl":"https://doi.org/10.14744/bmj.2023.36744","url":null,"abstract":"Objectives: Posterior circulation ischemia syndrome is a common feature of the poor blood flow to the posterior cerebral regions which is generally caused by atherosclerotic involvement of vertebral arteries (VA). However, the risk factors for VA atherosclerosis remain largely unknown. Lipoprotein (a) (Lp(a)), a modified low-density lipoprotein, has been implicated as a risk factor for coronary and peripheral artery disease. Our aim was to investigate the possible association of Lp(a) with low vertebral artery flow, a marker representing VA atherosclerosis. Methods: An institutional registry database was used for the present study. A complete dataset, including Doppler ultrasound imaging of the carotid and VA was available in 135 of 718 cases, and these cases were included in the analysis. Results: 29 (21.1%) patients had Lp(a)>30 mg/dL, and total VA flow in these patients was significantly less than in patients with Lp(a)<30 mg/dL (243.0 mL/min [212.0–276.0] vs. 256.0 mL/min [230.0–307.0], p=0.03). Lp(a) had a significant correlation with VA flow (r=−0.24, p=0.004), and this association remained significant after adjustment for other lipid parameters (β=−0.244, p=0.004) and demographic variables (β=−0.225, p=0.007). Furthermore, the correlation between Lp(a) and VA flow was stronger in 11 patients with evidence of carotid atherosclerosis on DUS (r=−0.74, p<0.001). Conclusion:","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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