Objective: To compare the efficacy and local adverse effects of Isoconazole Nitrate versus Nystatin for the treatment of patients having Otomycosis Sudy Design: Group experimental study. Study Setting & Duration: Department of Otolaryngology, Head & Neck Surgery at Rawalpindi Teaching Hospital, Rawalpindi. Duration of study was 6 months after approval by Ethical Committee from Feb 2023 to july 2023 Materials and Methods: Total of 64 patients were selected. The study participants were individuals who, according to operational definitions had Otomycosis and who had presented for evaluation at the Department of Otolaryngology Rawalpindi teaching Hospital, Rawalpindi. They also met all inclusion and exclusion criteria requirements and these requirements were strictly adhered to in order to control confounders and bias. Isoconazole nitrate ointment was used to treat patients in Group A and Nystatin ointment was used to treat instances in Group B. Patients were chosen by randomization using lottery method. SPSS 28 was used to determine the frequencies in the data. Results: 64 individuals (32 cases in each group) were chosen for the study by the ENT outpatient clinic. Out of which 33 (51.6%) being female and 31 (48.1) being male. The age ranged from 12 to 80 years, with a mean age of 44.29 ±19.13. After two weeks, there was a substantial improvement in 25 (39.06%) of the group A patients (p=0.08), a moderate improvement in 7 (10.9%), and a minor improvement in 5 (7.81%) patients (p=0.37) while in group B exhibited a substantial improvement in just 19 (10.9%) (p=0.08), a moderate improvement in 9 (39.0%) (p=0.38), and a small improvement in 7 (42.19%) (p=0.37). After four weeks 21 (32.81%) in Group B showed insignificant improvement, while 26 (40.63%) in Group A exhibited better improvement than Group B. The treatment for group A, which included isoconazole nitrate, was substantially more successful than the Nystatin treatment for group B. Isoconazole was found insignificantly more effective than (p=0.08). The majority of patients in both groups didn't notice any adverse . Conclusion: Nystatin was shown to be significantly less efficacious than isoconazole nitrate ointment in treating otomycosis.
{"title":"Comparison Of Isoconazole Nitrate Versus Nystatin For The Treatment Of Otomycosis","authors":"Amna Kausar, Sadia Chaudhry, Nighat Qammar, A. Akram, Ashar Alamgir, Wajid Hussain","doi":"10.37939/jrmc.v27i3.2372","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2372","url":null,"abstract":"Objective: To compare the efficacy and local adverse effects of Isoconazole Nitrate versus Nystatin for the treatment of patients having Otomycosis Sudy Design: Group experimental study. Study Setting & Duration: Department of Otolaryngology, Head & Neck Surgery at Rawalpindi Teaching Hospital, Rawalpindi. Duration of study was 6 months after approval by Ethical Committee from Feb 2023 to july 2023 Materials and Methods: Total of 64 patients were selected. The study participants were individuals who, according to operational definitions had Otomycosis and who had presented for evaluation at the Department of Otolaryngology Rawalpindi teaching Hospital, Rawalpindi. They also met all inclusion and exclusion criteria requirements and these requirements were strictly adhered to in order to control confounders and bias. Isoconazole nitrate ointment was used to treat patients in Group A and Nystatin ointment was used to treat instances in Group B. Patients were chosen by randomization using lottery method. SPSS 28 was used to determine the frequencies in the data. Results: 64 individuals (32 cases in each group) were chosen for the study by the ENT outpatient clinic. Out of which 33 (51.6%) being female and 31 (48.1) being male. The age ranged from 12 to 80 years, with a mean age of 44.29 ±19.13. After two weeks, there was a substantial improvement in 25 (39.06%) of the group A patients (p=0.08), a moderate improvement in 7 (10.9%), and a minor improvement in 5 (7.81%) patients (p=0.37) while in group B exhibited a substantial improvement in just 19 (10.9%) (p=0.08), a moderate improvement in 9 (39.0%) (p=0.38), and a small improvement in 7 (42.19%) (p=0.37). After four weeks 21 (32.81%) in Group B showed insignificant improvement, while 26 (40.63%) in Group A exhibited better improvement than Group B. The treatment for group A, which included isoconazole nitrate, was substantially more successful than the Nystatin treatment for group B. Isoconazole was found insignificantly more effective than (p=0.08). The majority of patients in both groups didn't notice any adverse . Conclusion: Nystatin was shown to be significantly less efficacious than isoconazole nitrate ointment in treating otomycosis.","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.37939/jrmc.v27i3.2245
Saeed Baseer, Atiq Ur Rehman, Aftab Kalwar, Hina Jamal, Sajid Razzaq, Nasir Zareen
Objective: To determine the diagnostic accuracy of serum Bilirubin in cases of acute appendicitis keeping the histopathological findings as Gold standard. Study Design: Cross sectional validation study. Place and Duration of the Study: Surgical Unit, Sheikh Khalifa Bin Zayed Al-Nayhan Hospital (Combined Military Hospital), Rawalakot, Azad Kashmir, from Jan 2022 to June 2022. Methodology: A total of 380 patients aged between 18 to 65 years, who matched the inclusion and exclusion criteria suspected of acute appendicitis were included. Serum Bilirubin level was noted. Appendectomy was done. Specimen of appendix was sent for histopathology for confirmation of the diagnosis. Results: In our study, mean age of the patients was 34.015 with a standard deviation of 13.32. 65% (n=247) of the patients were males and 35% (n=133) were females. Frequency of acute appendicitis on histopathology was 82.89% (n=315) while 17.1% (n=65) had no findings of the disease. Validity of serum Bilirubin in diagnosing appendicitis using histopathology showed 57.36% (n=218) were true positive, 2.1% (n=8) were false positive, 15% (n=57) were true negative and 25.52 %( n=97) were false negative. Specificity, sensitivity, negative predictive value, positive predictive value, accuracy rate, positive likelihood ratio and negative likelihood ratio were 87.69%, 69.20%, 37.01%, 96.46%, 72.36%, 5.62 and 0.35 respectively. Conclusion: Serum Bilirubin is a useful marker for diagnosing the acute appendicitis and can be used as a good alternative diagnostic modality in suspected cases of acute appendicitis.
{"title":"Diagnostic Accuracy Of Hyperbilirubinemia In Acute Appendicitis","authors":"Saeed Baseer, Atiq Ur Rehman, Aftab Kalwar, Hina Jamal, Sajid Razzaq, Nasir Zareen","doi":"10.37939/jrmc.v27i3.2245","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2245","url":null,"abstract":"Objective: To determine the diagnostic accuracy of serum Bilirubin in cases of acute appendicitis keeping the histopathological findings as Gold standard. Study Design: Cross sectional validation study. Place and Duration of the Study: Surgical Unit, Sheikh Khalifa Bin Zayed Al-Nayhan Hospital (Combined Military Hospital), Rawalakot, Azad Kashmir, from Jan 2022 to June 2022. Methodology: A total of 380 patients aged between 18 to 65 years, who matched the inclusion and exclusion criteria suspected of acute appendicitis were included. Serum Bilirubin level was noted. Appendectomy was done. Specimen of appendix was sent for histopathology for confirmation of the diagnosis. Results: In our study, mean age of the patients was 34.015 with a standard deviation of 13.32. 65% (n=247) of the patients were males and 35% (n=133) were females. Frequency of acute appendicitis on histopathology was 82.89% (n=315) while 17.1% (n=65) had no findings of the disease. Validity of serum Bilirubin in diagnosing appendicitis using histopathology showed 57.36% (n=218) were true positive, 2.1% (n=8) were false positive, 15% (n=57) were true negative and 25.52 %( n=97) were false negative. Specificity, sensitivity, negative predictive value, positive predictive value, accuracy rate, positive likelihood ratio and negative likelihood ratio were 87.69%, 69.20%, 37.01%, 96.46%, 72.36%, 5.62 and 0.35 respectively. Conclusion: Serum Bilirubin is a useful marker for diagnosing the acute appendicitis and can be used as a good alternative diagnostic modality in suspected cases of acute appendicitis.","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.37939/jrmc.v27i3.2282
Erum Afaq, Muhammad Kashif Nisar, Asif Iqbal Khan, Mamoona Shafiq, Muhammad Irfan ul Akbar Yousufzai, Saeed Khan
Objective: This study aimed to investigate the impact of the Apo E polymorphisms on plasma lipid profile and to identify the polymorphism of the apo-E gene as genetic predictor of calcific AS in Pakistani population. Methodology: This was a case control study conducted in Dow University of Health Sciences and National Institute of Cardiovascular Disease, Karachi. It included total of 100 individuals, 50 echocardiographically identified calcific AS cases and 50 age and gender matched controls. Apo E allele frequencies were computed, lipid profiles were estimated and Apo E gene polymorphism was identified by the techniques of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Result: Apo E 2, 3, and 4 allele frequencies were 16%, 52%, and 32% in calcific AS cases, and 10%, 52%, 28% in controls respectively (p=0.622). Out of 50 cases, 18% presented with mild AS, 22% moderate AS and 60% lied in severe calcific AS. It was observed that levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) were higher in Apo E4 allele as compared to other genes in both cases and control. Conclusion: The findings of this study suggested that Apo E4 allele of Apo E gene is an impotent risk factors for dyslipidemia while Apo E4 allele is not associated with calcific AS contemplates distinctive genetic backgrounds of CAD and AS.
研究目的本研究旨在调查载脂蛋白 E 多态性对血浆脂质谱的影响，并确定载脂蛋白 E 基因多态性是巴基斯坦人群钙化性 AS 的遗传预测因子。 研究方法：这是一项在卡拉奇陶尔健康科学大学和国家心血管疾病研究所进行的病例对照研究。研究共包括 100 人，其中 50 人为超声心动图确定的钙化性 AS 病例，50 人为年龄和性别匹配的对照组。通过聚合酶链式反应（PCR）和限制性片段长度多态性（RFLP）技术，计算了载脂蛋白 E 等位基因频率，估计了血脂概况，并确定了载脂蛋白 E 基因多态性。 研究结果钙化性强直性脊柱炎病例中载脂蛋白E 2、3和4等位基因频率分别为16%、52%和32%，对照组分别为10%、52%和28%（P=0.622）。在50个病例中，18%为轻度强直性脊柱炎，22%为中度强直性脊柱炎，60%为重度钙化性强直性脊柱炎。据观察，在病例和对照组中，载脂蛋白 E4 等位基因的总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白（LDL）水平均高于其他基因。 结论本研究结果表明，载脂蛋白 E 基因的载脂蛋白 E4 等位基因是血脂异常的一个不确定的危险因素，而载脂蛋白 E4 等位基因与钙化性强直性脊柱炎无关，这说明 CAD 和强直性脊柱炎的遗传背景各不相同。
{"title":"Apolipoprotein E Polymorphism And Dyslipidemia In Elderly Patients Of Calcific Aortic Stenosis","authors":"Erum Afaq, Muhammad Kashif Nisar, Asif Iqbal Khan, Mamoona Shafiq, Muhammad Irfan ul Akbar Yousufzai, Saeed Khan","doi":"10.37939/jrmc.v27i3.2282","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2282","url":null,"abstract":"Objective: This study aimed to investigate the impact of the Apo E polymorphisms on plasma lipid profile and to identify the polymorphism of the apo-E gene as genetic predictor of calcific AS in Pakistani population. Methodology: This was a case control study conducted in Dow University of Health Sciences and National Institute of Cardiovascular Disease, Karachi. It included total of 100 individuals, 50 echocardiographically identified calcific AS cases and 50 age and gender matched controls. Apo E allele frequencies were computed, lipid profiles were estimated and Apo E gene polymorphism was identified by the techniques of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Result: Apo E 2, 3, and 4 allele frequencies were 16%, 52%, and 32% in calcific AS cases, and 10%, 52%, 28% in controls respectively (p=0.622). Out of 50 cases, 18% presented with mild AS, 22% moderate AS and 60% lied in severe calcific AS. It was observed that levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) were higher in Apo E4 allele as compared to other genes in both cases and control. Conclusion: The findings of this study suggested that Apo E4 allele of Apo E gene is an impotent risk factors for dyslipidemia while Apo E4 allele is not associated with calcific AS contemplates distinctive genetic backgrounds of CAD and AS.","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.37939/jrmc.v27i3.2302
R. Akhtar, Umer Zia Warraich, Riaz Ahmed, Muhammad Haider, Muhammad Umair Qammar, Armaghana Qamar Khan
INTRODUCTION: Distal radius fractures are one of the commonest fractures experienced by the Orthopaedic surgeons. Pain on the ulnar aspect of the wrist is the most usual complication of such fractures. Corticosteroid injection is a simple and effective method for elevating pain of such nature. OBJECTIVE: To compare the mean pain score with prophylactic corticosteroid injection versus placebo in management of wrist pain on ulnar aspect in patients presenting with fracture of distal radius. MATERIAL AND METHODS: Study Design: Randomized controlled trial Setting: Orthopedic Surgery Department, Benazir Bhutto Hospital, Rawalpindi Duration: Six months (March 5, 2018 to Sept 5, 2018) Data Collection Procedure: 80 patients were included by using non-probability consecutive sampling after fulfilling the selection criteria. Demographic profile (patient name, age, gender, anatomical side and contact details) was obtained. Patients were splitted in two random groups by simple lottery method. Patients of group A were given one shot of 80mg corticosteroid in the area of ulnar styloid process near TFCC and group B patients were given a shot of distilled water (2 cc). Both group of patients were followed in OPD for 3 months in their postoperative visits. Visual analogue scale (VAS) score was recorded. Data was analyzed using SPSS version 21. Results: The mean age of the patients was 41.05 ± 11.05 years and age range of 40 years. The mean age in the corticosteroid and placebo groups was 39.68±10.67 years and 42.42 ± 11.39 years respectively. There were 42 (52.50%) male and 38 (47.50%) female patients with a higher male ratio i.e., 1.10:1. In corticosteroid and placebo groups there were 21 (52.50%) male and 19 (47.50%) female cases. The mean pain at baseline was 7.72 ± 1.66 while in the corticosteroid and placebo group, the mean pain was 7.60 ± 1.67 and 7.85 ± 1.65 respectively with statistically equal mean pain p-value = 0.504. After 3 months of treatment, mean pain in the corticosteroid group was 1.30 ± 0.66 and was 2.60 ± 1.58 in the placebo group, p-value < 0.001. Conclusion: Our findings suggested that prophylactic corticosteroid injection is more effective in reducing pain in patients with distal radial fracture than placebo. By using prophylactic corticosteroid injections in the future, we can reduce pain to achieve more satisfaction of patients.
{"title":"Comparison Of Prophylactic Injection Of Corticosteroid With Placebo, In Management Of Wrist Pain On Ulnar Aspect In Patients Of Fractures Of Distal Radius","authors":"R. Akhtar, Umer Zia Warraich, Riaz Ahmed, Muhammad Haider, Muhammad Umair Qammar, Armaghana Qamar Khan","doi":"10.37939/jrmc.v27i3.2302","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2302","url":null,"abstract":"INTRODUCTION: Distal radius fractures are one of the commonest fractures experienced by the Orthopaedic surgeons. Pain on the ulnar aspect of the wrist is the most usual complication of such fractures. Corticosteroid injection is a simple and effective method for elevating pain of such nature. OBJECTIVE: To compare the mean pain score with prophylactic corticosteroid injection versus placebo in management of wrist pain on ulnar aspect in patients presenting with fracture of distal radius. MATERIAL AND METHODS: Study Design: Randomized controlled trial Setting: Orthopedic Surgery Department, Benazir Bhutto Hospital, Rawalpindi Duration: Six months (March 5, 2018 to Sept 5, 2018) Data Collection Procedure: 80 patients were included by using non-probability consecutive sampling after fulfilling the selection criteria. Demographic profile (patient name, age, gender, anatomical side and contact details) was obtained. Patients were splitted in two random groups by simple lottery method. Patients of group A were given one shot of 80mg corticosteroid in the area of ulnar styloid process near TFCC and group B patients were given a shot of distilled water (2 cc). Both group of patients were followed in OPD for 3 months in their postoperative visits. Visual analogue scale (VAS) score was recorded. Data was analyzed using SPSS version 21. Results: The mean age of the patients was 41.05 ± 11.05 years and age range of 40 years. The mean age in the corticosteroid and placebo groups was 39.68±10.67 years and 42.42 ± 11.39 years respectively. There were 42 (52.50%) male and 38 (47.50%) female patients with a higher male ratio i.e., 1.10:1. In corticosteroid and placebo groups there were 21 (52.50%) male and 19 (47.50%) female cases. The mean pain at baseline was 7.72 ± 1.66 while in the corticosteroid and placebo group, the mean pain was 7.60 ± 1.67 and 7.85 ± 1.65 respectively with statistically equal mean pain p-value = 0.504. After 3 months of treatment, mean pain in the corticosteroid group was 1.30 ± 0.66 and was 2.60 ± 1.58 in the placebo group, p-value < 0.001. Conclusion: Our findings suggested that prophylactic corticosteroid injection is more effective in reducing pain in patients with distal radial fracture than placebo. By using prophylactic corticosteroid injections in the future, we can reduce pain to achieve more satisfaction of patients.","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Objective: The aim of this study was to investigate the awareness regarding COVID-19 vaccines and identify the factors underlying refusal. Methodology: A cross-sectional study was carried out amongst the general population from different walk of life regarding awareness and myths about COVID-19 vaccine selected by convenient sampling method. To collect data, we developed an online survey using questionnaires regarding beliefs and myths about vaccination. The study was started in March 2021 after approval from the ethical committee. Survey consisting of several questions was created using google form. The link was shared on different social media applications and participants were requested to fill the questionnaires. Some patients and their attendants who were visiting HIT hospital Taxila for any reason were also included in the study and they were requested to fill the form at the spot. Participants were given a brief summary of the survey and its purpose, as well as the study protocol and a declaration of confidentiality and privacy, before beginning the questionnaire. Data was collected on online server form. Demographic information was noted. They were asked about their registration, vaccination status and their fear regarding vaccine and its complications. They were questioned about myths and misbeliefs about covid 19 vaccine. Post vaccination symptoms, their preference for different types of available vaccine, and need of booster dose were also inquired. Their beliefs regarding effectiveness of vaccine in prevention of covid-19 symptoms and severity and following the SOPs released by health authorities were noted. Results: Total 287 individuals were included in this study. 62% were females and 31% were males. 50% were doctors and 30% were not registered for vaccination. 70% of individuals were vaccinated and 83% were not afraid to get vaccination while 50% of people thought that they will get COVID-19 after vaccination. 35% participants were afraid that they will get allergic reaction post vaccination and 9% thought that COVID-19 is fake i.e., there is no such disease as COVID-19. 82% were aware that they will need vaccine even if they had COVID-19. Only 7% of population thought that COVID-19 will change their DNA. Chi square test was applied to find out statistically significant difference in opinion between three groups i.e., age, gender and academic qualification. Majority of the statistical correlation was found in these questions on the basis of qualification. There was statistically significant difference in opinion depending on academic qualification, health care and non-health care workers shown by p value less than 0.05. Health care professionals think there is need for new vaccinations for every new variant, there were mild covid symptoms post vaccination and there was need of booster dose every year while others have contrary opinion. Medical students didn’t believe in DNA alteration. Their was also statis
{"title":"Perception And Attitude Towards COVID-19 Vaccine: A Cross-Sectional Study From Pakistan","authors":"Kausar Malik, Faiza Batool, Saba Bari, Fatima Malik, Savida Ilyas Dar, Lubna Meraj","doi":"10.37939/jrmc.v27i3.2205","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2205","url":null,"abstract":"ABSTRACT Objective: The aim of this study was to investigate the awareness regarding COVID-19 vaccines and identify the factors underlying refusal. Methodology: A cross-sectional study was carried out amongst the general population from different walk of life regarding awareness and myths about COVID-19 vaccine selected by convenient sampling method. To collect data, we developed an online survey using questionnaires regarding beliefs and myths about vaccination. The study was started in March 2021 after approval from the ethical committee. Survey consisting of several questions was created using google form. The link was shared on different social media applications and participants were requested to fill the questionnaires. Some patients and their attendants who were visiting HIT hospital Taxila for any reason were also included in the study and they were requested to fill the form at the spot. Participants were given a brief summary of the survey and its purpose, as well as the study protocol and a declaration of confidentiality and privacy, before beginning the questionnaire. Data was collected on online server form. Demographic information was noted. They were asked about their registration, vaccination status and their fear regarding vaccine and its complications. They were questioned about myths and misbeliefs about covid 19 vaccine. Post vaccination symptoms, their preference for different types of available vaccine, and need of booster dose were also inquired. Their beliefs regarding effectiveness of vaccine in prevention of covid-19 symptoms and severity and following the SOPs released by health authorities were noted. Results: Total 287 individuals were included in this study. 62% were females and 31% were males. 50% were doctors and 30% were not registered for vaccination. 70% of individuals were vaccinated and 83% were not afraid to get vaccination while 50% of people thought that they will get COVID-19 after vaccination. 35% participants were afraid that they will get allergic reaction post vaccination and 9% thought that COVID-19 is fake i.e., there is no such disease as COVID-19. 82% were aware that they will need vaccine even if they had COVID-19. Only 7% of population thought that COVID-19 will change their DNA. Chi square test was applied to find out statistically significant difference in opinion between three groups i.e., age, gender and academic qualification. Majority of the statistical correlation was found in these questions on the basis of qualification. There was statistically significant difference in opinion depending on academic qualification, health care and non-health care workers shown by p value less than 0.05. Health care professionals think there is need for new vaccinations for every new variant, there were mild covid symptoms post vaccination and there was need of booster dose every year while others have contrary opinion. Medical students didn’t believe in DNA alteration. Their was also statis","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.37939/jrmc.v27i3.2059
M. Shaheer, Asima Rafique
Background: The purpose of this study was to get an idea of the impact of COVID-19 on Ophthalmology post-graduate training. Materials & methods: This cross-sectional questionnaire-based study was conducted at the College of Ophthalmology and Allied Vision Sciences/Eye Unit III (King Edward Medical University), Lahore from 01-03-2021 to 31-08-2021. A web-based close-ended questionnaire (Google form) was developed consisting of questions related to residency training in the wake of the COVID-19 pandemic. Eighty-one Ophthalmology residents from across the country participated in this survey. Based on the responses to 21 questions, percentages of various variables in questions were calculated. Data analysis was done on SPSS version 22. Responses to questions are mainly presented as percentages. A chi-square test was applied to see the significant difference in survey questions. For categorical variables, Fisher’s Exact test was applied. P-value ≤0.05 is considered significant. Results: Twenty-seven ophthalmology residents were 1st year residents 23 were 2nd year residents while 3rd and 4th year residents were 14 and 17 respectively. 33% of residents thought their surgical training was affected badly due to covid-19 pandemic while 55% of them were concerned about their basic cataract surgery skills. 67% of residents were in favour of their training extension for 6-12 months. The majority of residents stated that COVID-19 affected their training adversely (p=0.000) and cataract surgery training was the most affected one (p=0.000) Conclusion: The COVID-19 pandemic has severely affected the clinical and surgical training of post-graduate ophthalmology residents. Formulation of institution-based & nationwide short and long-term strategies regarding web-based teaching, surgical simulation courses and necessary adjustments in curriculum are the need of the hour.
{"title":"Impact Of COVID-19 Pandemic On Ophthalmology Residency Training- A Cross-Sectional Survey Among Pakistani Residents","authors":"M. Shaheer, Asima Rafique","doi":"10.37939/jrmc.v27i3.2059","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2059","url":null,"abstract":"Background: The purpose of this study was to get an idea of the impact of COVID-19 on Ophthalmology post-graduate training. Materials & methods: This cross-sectional questionnaire-based study was conducted at the College of Ophthalmology and Allied Vision Sciences/Eye Unit III (King Edward Medical University), Lahore from 01-03-2021 to 31-08-2021. A web-based close-ended questionnaire (Google form) was developed consisting of questions related to residency training in the wake of the COVID-19 pandemic. Eighty-one Ophthalmology residents from across the country participated in this survey. Based on the responses to 21 questions, percentages of various variables in questions were calculated. Data analysis was done on SPSS version 22. Responses to questions are mainly presented as percentages. A chi-square test was applied to see the significant difference in survey questions. For categorical variables, Fisher’s Exact test was applied. P-value ≤0.05 is considered significant. Results: Twenty-seven ophthalmology residents were 1st year residents 23 were 2nd year residents while 3rd and 4th year residents were 14 and 17 respectively. 33% of residents thought their surgical training was affected badly due to covid-19 pandemic while 55% of them were concerned about their basic cataract surgery skills. 67% of residents were in favour of their training extension for 6-12 months. The majority of residents stated that COVID-19 affected their training adversely (p=0.000) and cataract surgery training was the most affected one (p=0.000) Conclusion: The COVID-19 pandemic has severely affected the clinical and surgical training of post-graduate ophthalmology residents. Formulation of institution-based & nationwide short and long-term strategies regarding web-based teaching, surgical simulation courses and necessary adjustments in curriculum are the need of the hour.","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.37939/jrmc.v27i3.2262
Sadaf Asma, S. Muntaha, Amerzish Liaqat, Farhan Hassan, Sara Hayat, Rafiq Ahmed
OBJECTIVE: To assess the diagnostic accuracy of raised serum uric acid level in females with pre-eclampsia, in predicting low birth weight. SUBJESTS & METHODS: Cross sectional study carried out at Gynecology Department, FGSH Poly Clinic, Islamabad & duration of study was 6 months from July 21, 2021 to Jan 20, 2022. A total of 225 Preeclampsia pregnant female were clinically examined and included in the study. Blood sample were collected for serum uric acid and followed till the birth of the baby. RESULTS: The study included age ranged from 18 up to 40 years. Average age was 28.69years +5.01SD. Sensitivity & specificity of uric acid level in Serum in diagnosis of low birth weight are 85.71% and 81.42% respectively while it has positive predictive & negative predictive value of 51.43% & 96.13% respectively. Diagnostic accuracy of uric acid level in serum was 82.22%. CONCLUSION: Uric acid level in serum is of great diagnostic and prognostic importance in women with pre-eclampsia & helps in predicting low birth weight.
{"title":"Assessment Of Predictive Value Of Serum Uric Acid Levels For Low Birth Weight In Pre-Eclampsia","authors":"Sadaf Asma, S. Muntaha, Amerzish Liaqat, Farhan Hassan, Sara Hayat, Rafiq Ahmed","doi":"10.37939/jrmc.v27i3.2262","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2262","url":null,"abstract":"OBJECTIVE: To assess the diagnostic accuracy of raised serum uric acid level in females with pre-eclampsia, in predicting low birth weight. SUBJESTS & METHODS: Cross sectional study carried out at Gynecology Department, FGSH Poly Clinic, Islamabad & duration of study was 6 months from July 21, 2021 to Jan 20, 2022. A total of 225 Preeclampsia pregnant female were clinically examined and included in the study. Blood sample were collected for serum uric acid and followed till the birth of the baby. RESULTS: The study included age ranged from 18 up to 40 years. Average age was 28.69years +5.01SD. Sensitivity & specificity of uric acid level in Serum in diagnosis of low birth weight are 85.71% and 81.42% respectively while it has positive predictive & negative predictive value of 51.43% & 96.13% respectively. Diagnostic accuracy of uric acid level in serum was 82.22%. CONCLUSION: Uric acid level in serum is of great diagnostic and prognostic importance in women with pre-eclampsia & helps in predicting low birth weight.","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.37939/jrmc.v27i3.2322
Tafiya Erum Kamran, Hadia Wali, Samana Batool, Zainab Rasheed, S. Ansari
Abstract This case report aims to present an unusual case of a plunging ranula that extended to the superior vertebral body of the T4 vertebrae, we will be elaborating on the patient presentation, investigations, diagnosis, and treatment of the lesion, while also talking about the adversities faced while diagnosing and treating the patient. The rarity of this condition and an atypical presentation makes this a difficult case to diagnose and vigilant treatment is needed to prevent any complications associated with the condition and ensure a successful treatment and recovery.
{"title":"Case Report Of A Giant Plunging Ranula In A 25-Year-Old Patient","authors":"Tafiya Erum Kamran, Hadia Wali, Samana Batool, Zainab Rasheed, S. Ansari","doi":"10.37939/jrmc.v27i3.2322","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2322","url":null,"abstract":"Abstract This case report aims to present an unusual case of a plunging ranula that extended to the superior vertebral body of the T4 vertebrae, we will be elaborating on the patient presentation, investigations, diagnosis, and treatment of the lesion, while also talking about the adversities faced while diagnosing and treating the patient. The rarity of this condition and an atypical presentation makes this a difficult case to diagnose and vigilant treatment is needed to prevent any complications associated with the condition and ensure a successful treatment and recovery.","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"2014 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Preterm birth (PTB) occurs between 24-37 weeks of gestation. The important risk factor for PTB is a previous PTB and currently progesterone is used for the management of recurrent spontaneous PTB. Some studies have shown good outcomes but recent studies revealed that the use of vaginal progesterone was not related to a decreased likelihood of PTB or neonatal adverse effects. Thus, the controversy in the literature suggests multiple underlying pathological mechanisms involved in the progression of PTB. This study aims to determine the role of low-dose aspirin in the prevention of preterm birth in patients with a previous history of preterm delivery. Methodology: In this randomized controlled trial, a total of 172 patients fulfilling the inclusion criteria were selected from the inpatient and outpatient departments. Patients were divided randomly into two groups (group A and group B), using random number tables. In Group A, low-dose aspirin (75mg) was given while group B was taken as a control group. Patients were called every 8 weeks in the outpatient department for the assessment of compliance and side effects of the drug. The data were entered and analyzed by using SPSS v25.0. Chi-square was used to compare the two groups for incidence of preterm birth. Relative risk (along with a 95% confidence interval) for the decrease in the incidence of preterm birth with the use of aspirin was calculated. Results: The age of participants included in the study was 18 to 40 years. The mean age of patients in group A was 33.85±5.210 years and in group B was 32.86±4.139 years. The mean fetal birth weight in group A was 2281.1962±363.125 grams and in group B was 2271.4344±374.797 grams. In the low-dose aspirin group, 10(11.6%) had preterm birth and 31(36.0%) in the control group with a p-value of 0.001, which is statistically significant. The risk of having preterm birth with low-dose aspirin was 1.801 times less than controls. Conclusion: aspirin in low dose given before 14 weeks of gestation decrease spontaneous preterm birth as compared to the control group in a woman with a history of previous preterm birth which was spontaneous
{"title":"Role Of Low Dose Aspirin In Preventing Preterm Birth In Patients With Previous History Of Preterm Delivery","authors":"Maliha Sadaf, Aasia Saleem, Tallat Farkhanda, Khansa Iqbal, Sabeen Ashraf, Amna Iftikhar","doi":"10.37939/jrmc.v27i3.2363","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2363","url":null,"abstract":"Objective: Preterm birth (PTB) occurs between 24-37 weeks of gestation. The important risk factor for PTB is a previous PTB and currently progesterone is used for the management of recurrent spontaneous PTB. Some studies have shown good outcomes but recent studies revealed that the use of vaginal progesterone was not related to a decreased likelihood of PTB or neonatal adverse effects. Thus, the controversy in the literature suggests multiple underlying pathological mechanisms involved in the progression of PTB. This study aims to determine the role of low-dose aspirin in the prevention of preterm birth in patients with a previous history of preterm delivery. Methodology: In this randomized controlled trial, a total of 172 patients fulfilling the inclusion criteria were selected from the inpatient and outpatient departments. Patients were divided randomly into two groups (group A and group B), using random number tables. In Group A, low-dose aspirin (75mg) was given while group B was taken as a control group. Patients were called every 8 weeks in the outpatient department for the assessment of compliance and side effects of the drug. The data were entered and analyzed by using SPSS v25.0. Chi-square was used to compare the two groups for incidence of preterm birth. Relative risk (along with a 95% confidence interval) for the decrease in the incidence of preterm birth with the use of aspirin was calculated. Results: The age of participants included in the study was 18 to 40 years. The mean age of patients in group A was 33.85±5.210 years and in group B was 32.86±4.139 years. The mean fetal birth weight in group A was 2281.1962±363.125 grams and in group B was 2271.4344±374.797 grams. In the low-dose aspirin group, 10(11.6%) had preterm birth and 31(36.0%) in the control group with a p-value of 0.001, which is statistically significant. The risk of having preterm birth with low-dose aspirin was 1.801 times less than controls. Conclusion: aspirin in low dose given before 14 weeks of gestation decrease spontaneous preterm birth as compared to the control group in a woman with a history of previous preterm birth which was spontaneous","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"160 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To determine the diagnostic accuracy of Barium Swallow in detection of patients presenting with dysphagia. Study Design: Cross-sectional validation study. Study Setting & Duration: Department of Otorhinolaryngology, Head & Neck Surgery, District Headquarter Hospital Rawalpindi from 01-09- 2022 to 01-03-2023. Materials and Methods: Approval of the study was obtained from the Hospital Ethical Committee. A total of 111 patients both male and female patients were selected. The patients suffering from dysphagia as per operational definitions and who have reported for work-up to the Department of ENT, District Headquarters Hospital, Rawalpindi, and fulfill the complete inclusion and exclusion criteria, were selected. Informed consent was obtained from all the patients. Patients were selected by consecutive non-probability sampling technique. The data was analyzed using SPSS 24. Results: A total of 111 patients were included in this study. The mean age of these patients was 50.79 ± 13.01 years, ranging from 28 to 70 years. The frequency distribution of females 70.27 % was found to be more than that of males 29.73 %. Majority of patients' barium swallow (74.77%) revealed pathologies, while only a small percentage of patients (25.23%) had normal barium swallow. Most of patients (87.39%) had pathologies found during rigid esophagoscopy, while just a small number (12.61%) had normal rigid esophagoscopy. Comparing both investigating tools, esophagoscopy discovered 87.39% of pathologies while Barium swallow detected 74.77%, indicating that esophagoscopy was a more accurate procedure. Patients had esophageal web 55 (25.2%) on barium swallow and 69 (62.2%) on the Rigid esophagoscopy. Barium Swallow had esophageal stricture 28 (52.2) and no Pathology was detected in 28 (25.2 %) patients. As well as Rigid esophagoscopy had esophageal growth13 (11.7), esophageal stricture 15 (13.5), and no Pathology was detected in 14 (12.6 %). Rigid esophagoscopy is more efficient in detecting esophageal pathology than Barium Swallow. In Barium swallows most patients had esophageal web 55 (25.2%) than the esophageal stricture 28 (52.2) and no pathology was detected 28 (25.2). In rigid esophagoscopy most patients had esophageal web 69 (62.2%) than the esophageal growth13 (11.7), esophageal stricture 15 (13.5) and no pathology detected 14 (12.6). Conclusion: A range of diseases are associated with dysphagia can be found in patients. Two often used diagnostic methods are barium swallow and rigid esophagoscopy. Both Barium swallow and Rigid esophagoscopy are successful in the diagnosis of esophageal cancer. The use of a Rigid esophagoscopy is still a gold standard diagnostic and therapeutic tool for upper aerodigestive tract pathologies.
{"title":"Diagnostic Accuracy Of Barium Swallow For Dysphagia, Keeping Rigid Esophagoscopy As The Gold Standard","authors":"A. Akram, Sadia Chaudhry, Sundas Masood, Amna Kausar, Seema Naveed, Areesha Manzoor","doi":"10.37939/jrmc.v27i3.2371","DOIUrl":"https://doi.org/10.37939/jrmc.v27i3.2371","url":null,"abstract":"Objective: To determine the diagnostic accuracy of Barium Swallow in detection of patients presenting with dysphagia. Study Design: Cross-sectional validation study. Study Setting & Duration: Department of Otorhinolaryngology, Head & Neck Surgery, District Headquarter Hospital Rawalpindi from 01-09- 2022 to 01-03-2023. Materials and Methods: Approval of the study was obtained from the Hospital Ethical Committee. A total of 111 patients both male and female patients were selected. The patients suffering from dysphagia as per operational definitions and who have reported for work-up to the Department of ENT, District Headquarters Hospital, Rawalpindi, and fulfill the complete inclusion and exclusion criteria, were selected. Informed consent was obtained from all the patients. Patients were selected by consecutive non-probability sampling technique. The data was analyzed using SPSS 24. Results: A total of 111 patients were included in this study. The mean age of these patients was 50.79 ± 13.01 years, ranging from 28 to 70 years. The frequency distribution of females 70.27 % was found to be more than that of males 29.73 %. Majority of patients' barium swallow (74.77%) revealed pathologies, while only a small percentage of patients (25.23%) had normal barium swallow. Most of patients (87.39%) had pathologies found during rigid esophagoscopy, while just a small number (12.61%) had normal rigid esophagoscopy. Comparing both investigating tools, esophagoscopy discovered 87.39% of pathologies while Barium swallow detected 74.77%, indicating that esophagoscopy was a more accurate procedure. Patients had esophageal web 55 (25.2%) on barium swallow and 69 (62.2%) on the Rigid esophagoscopy. Barium Swallow had esophageal stricture 28 (52.2) and no Pathology was detected in 28 (25.2 %) patients. As well as Rigid esophagoscopy had esophageal growth13 (11.7), esophageal stricture 15 (13.5), and no Pathology was detected in 14 (12.6 %). Rigid esophagoscopy is more efficient in detecting esophageal pathology than Barium Swallow. In Barium swallows most patients had esophageal web 55 (25.2%) than the esophageal stricture 28 (52.2) and no pathology was detected 28 (25.2). In rigid esophagoscopy most patients had esophageal web 69 (62.2%) than the esophageal growth13 (11.7), esophageal stricture 15 (13.5) and no pathology detected 14 (12.6). Conclusion: A range of diseases are associated with dysphagia can be found in patients. Two often used diagnostic methods are barium swallow and rigid esophagoscopy. Both Barium swallow and Rigid esophagoscopy are successful in the diagnosis of esophageal cancer. The use of a Rigid esophagoscopy is still a gold standard diagnostic and therapeutic tool for upper aerodigestive tract pathologies.","PeriodicalId":34174,"journal":{"name":"Journal of Rawalpindi Medical College","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139336004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：