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Barriers and drivers of voluntary blood donation in northern and Western Tanzania 坦桑尼亚北部和西部自愿献血的障碍和驱动因素
Q2 Multidisciplinary Pub Date : 2022-02-09 DOI: 10.12688/aasopenres.13313.1
Florian Finda, Marceline F. Finda, A. Olotu
Introduction: Every second, someone in the world needs blood due to surgery, trauma, severe anemia or pregnancy complications. There is a shortage of blood for transfusion worldwide, with the heaviest burden faced by sub–Saharan Africa. In countries like Tanzania, the major source of blood is voluntary blood donation, making its supply one of the most challenging in the health care system. This study assessed the magnitude of the deficit of blood in blood banks, and explored views of key stakeholders on the need, availability and opportunities for improving blood donations in northern and Western Tanzania. Methods: This was an explanatory sequential mixed method study done in the Mpanda and Moshi districts in the Katavi and Kilimanjaro regions. A quantitative component involved a questionnaire survey with 253 community members from the two districts and 24 months blood bank records. The survey explored awareness and perceptions of voluntary blood donation. A qualitative component involved four focus group discussions with registered voluntary blood donors and health care providers from the National Blood Transfusion Service in the two districts. Results: Blood bank records indicated that more blood was collected in Katavi compared to the Kilimanjaro region. Only 26% of the survey respondents had ever donated blood in their lifetime, three quarters of these were from Mpanda district. There was no significant association between socio-demographic factors and likelihood of blood donation. However, being male, older (51 years and above), having higher household income and secondary school education were significantly associated with higher awareness of voluntary blood donation. Community sensitization, education, incentives and availability of blood donation centers near communities were among the most important factors listed to improve blood donation. Conclusions: Significant efforts need to be placed on sensitization and improving knowledge and awareness of voluntary blood donations in order to improve its uptake.
简介:世界上每一秒都有人因手术、创伤、严重贫血或妊娠并发症而需要血液。世界范围内的输血短缺,撒哈拉以南非洲面临着最沉重的负担。在坦桑尼亚等国,血液的主要来源是自愿献血,这使其供应成为医疗系统中最具挑战性的血液之一。这项研究评估了血库血液短缺的程度,并探讨了主要利益相关者对坦桑尼亚北部和西部改善献血的必要性、可用性和机会的看法。方法:这是一项在卡塔维和乞力马扎罗地区的姆潘达和莫西地区进行的解释性顺序混合方法研究。定量部分包括对来自两个地区的253名社区成员进行的问卷调查和24个月的血库记录。这项调查探讨了人们对自愿献血的认识和看法。质量部分包括与两个地区的注册自愿献血者和国家输血服务局的医疗保健提供者进行的四个重点小组讨论。结果:血库记录显示,与乞力马扎罗山地区相比,卡塔维采集的血液更多。只有26%的受访者一生中曾献血,其中四分之三来自姆潘达区。社会人口因素与献血的可能性之间没有显著的相关性。然而,男性、年龄较大(51岁及以上)、家庭收入较高、受过中学教育与自愿献血意识较高显著相关。社区宣传、教育、激励措施以及社区附近献血中心的可用性是改善献血的最重要因素。结论:需要大力提高对自愿献血的认识和认识,以提高其接受率。
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引用次数: 1
A survey on knowledge, attitude, and practice about antibiotic prescribing and resistance among medical practitioners in Kenya 肯尼亚医务人员关于抗生素处方和耐药性的知识、态度和实践调查
Q2 Multidisciplinary Pub Date : 2022-02-04 DOI: 10.12688/aasopenres.13328.1
M. Kamita, J. Mutungi, S. Mungai, D. Mureithi, C. Kijogi, R. Kimani, D. Ndegwa, J. Maina, J. Gitaka
Background Antibiotic resistance is a growing global health threat worldwide and especially in developing countries. Irrational antibiotic prescription as well as lack of the requisite knowledge and awareness of proper antibiotic use are major drivers of antibiotic resistance. In Kenya, although the Ministry of Health has developed antibiotic use guidelines, these guidelines are not widely followed. Antibiotic prescription is, therefore, hugely at the discretion of the clinician. It is thus necessary to understand the knowledge, attitude, and practices (KAP) of antibiotic prescription among medical practitioners in the country. This study aimed to evaluate the knowledge, attitude, and practices (KAP) among antibiotic prescribers in three counties (Kiambu, Nakuru, and Bungoma) in Kenya. Methods This was a cross-sectional study using a self-administered questionnaire. Simple descriptive statistics were used to generate frequencies, percentages, and proportions. Where necessary, univariate analyses such as Pearson’s chi-square were performed to compare proportions for statistical significance. Results From the three counties, 240 respondents recorded their responses: 30% from Kiambu, 34.6% from Nakuru, and 35.4% from Bungoma. The respondents included 19 (7.9%) consultants, 66 (27.4%) medical officers, 135 (56.3%) clinical officers and 20 (8.3%) pharmacists. Of all respondents, more than 90% agreed or strongly agreed that antibiotic resistance (ABR) is a catastrophe worldwide and in Kenya. However, the proportion of the respondents who either agreed or strongly agreed (71.6%) that antibiotic resistance is a problem in their respective health facilities was significantly lower (ρ=0.013). Conclusion This study revealed that most medical practitioners were aware and knowledgeable about antibiotic resistance. However, there was a disconnect with mitigation measures such as active antibiotic stewardship and laboratory analyses to support judicious prescription. There is, therefore, a need for continuous education and stewardship interventions.
背景抗生素耐药性是全球范围内日益严重的健康威胁,尤其是在发展中国家。不合理的抗生素处方以及缺乏正确使用抗生素的必要知识和意识是抗生素耐药性的主要驱动因素。在肯尼亚,尽管卫生部制定了抗生素使用指南,但这些指南并没有得到广泛遵守。因此,抗生素处方在很大程度上由临床医生自行决定。因此,有必要了解该国医生对抗生素处方的知识、态度和实践(KAP)。本研究旨在评估肯尼亚三个县(Kiambu、Nakuru和Bungoma)抗生素处方医生的知识、态度和实践(KAP)。方法采用自填问卷进行横断面调查。使用简单的描述性统计数据来生成频率、百分比和比例。必要时,进行单变量分析,如皮尔逊卡方,以比较统计显著性的比例。结果来自三个县的240名受访者记录了他们的回答:30%来自Kiambu,34.6%来自Nakuru,35.4%来自Bungoma。受访者包括19名(7.9%)顾问、66名(27.4%)医务人员、135名(56.3%)临床人员和20名(8.3%)药剂师。在所有受访者中,超过90%的人同意或强烈同意抗生素耐药性(ABR)在全球和肯尼亚都是一场灾难。然而,同意或强烈同意抗生素耐药性是各自卫生机构中的一个问题的受访者比例(71.6%)明显较低(ρ=0.013)。结论本研究表明,大多数医生都知道并了解抗生素耐药性。然而,与积极的抗生素管理和实验室分析等缓解措施存在脱节,以支持明智的处方。因此,需要继续进行教育和管理干预。
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引用次数: 1
Synthesis of bismuth oxyhalide (BiOBr zI (1- z)) solid solutions for photodegradation of methylene blue dye. 合成氧化卤化铋(BiOBr zI (1- z))光降解亚甲基蓝染料固溶体。
Q2 Multidisciplinary Pub Date : 2022-02-04 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13249.2
Robert O Gembo, Ochieng Aoyi, Stephen Majoni, Anita Etale, Sebusi Odisitse, Cecil K King'ondu

Background: The removal of textile wastes is a priority due to their mutagenic and carcinogenic properties.  In this study, bismuth oxyhalide was used in the removal of methylene blue (MB) which is a textile waste. The main objective of this study was to develop and investigate the applicability of a bismuth oxyhalide (BiOBr zI (1-z)) solid solutions in the photodegradation of MB under solar and ultraviolet (UV) light irradiation. Methods: Bismuth oxyhalide (BiOBr zI (1-z)) (0 ≤ z ≤ 1) materials were successfully prepared through the hydrothermal method. Brunauer-Emmett-Teller (BET), transmission electron microscope (TEM), X-ray diffractometer (XRD), and scanning electron microscope (SEM) were used to determine the surface area, microstructure, crystal structure, and morphology of the resultant products. The photocatalytic performance of BiOBr zI (1-z) materials was examined through methylene blue (MB) degradation under UV light and solar irradiation. Results: The XRD showed that BiOBr zI (1-z) materials crystallized into a tetragonal crystal structure with (102) peak slightly shifting to lower diffraction angle with an increase in the amount of iodide (I -). BiOBr 0.6I 0.4 materials showed a point of zero charge of 5.29 and presented the highest photocatalytic activity in the removal of MB with 99% and 88% efficiency under solar and UV irradiation, respectively. The kinetics studies of MB removal by BiOBr zI (1-z) materials showed that the degradation process followed nonlinear pseudo-first-order model indicating that the removal of MB depends on the population of the adsorption sites. Trapping experiments confirmed that photogenerated holes (h +) and superoxide radicals ( O 2 -) are the key species responsible for the degradation of MB. Conclusions : This study shows that bismuth oxyhalide materials are very active in the degradation of methylene blue dye using sunlight and thus they have great potential in safeguarding public health and the environment from the dye's degradation standpoint. Moreover, the experimental results agree with nonlinear fitting.

背景:由于纺织废料具有致突变和致癌性,因此对其进行处理是当务之急。研究了氧化卤化铋对纺织废渣亚甲基蓝(MB)的脱除作用。本研究的主要目的是开发和研究氧化卤化铋(BiOBr zI (1-z))固溶体在太阳和紫外线(UV)光照射下光降解MB的适用性。方法:采用水热法制备氧化卤化铋(BiOBr zI (1-z))(0≤z≤1)材料。采用布鲁诺尔-埃米特-泰勒(BET)、透射电子显微镜(TEM)、x射线衍射仪(XRD)和扫描电子显微镜(SEM)对所得产物的表面积、微观结构、晶体结构和形貌进行了测定。在紫外光和太阳照射下,通过亚甲基蓝(MB)降解研究了BiOBr zI (1-z)材料的光催化性能。结果:XRD结果表明,BiOBr zI (1-z)材料随着碘化物(I -)用量的增加而结晶成四方晶结构,(102)峰向低衍射角微移。BiOBr 0.6I 0.4材料在太阳和紫外线照射下的零电荷点为5.29,光催化去除MB的效率最高,分别为99%和88%。BiOBr zI (1-z)材料去除MB的动力学研究表明,降解过程遵循非线性伪一阶模型,表明MB的去除取决于吸附位点的居群。捕集实验证实,光生空穴(h +)和超氧自由基(•o2 -)是降解MB的关键物质。结论:本研究表明,氧化卤化铋材料在利用阳光降解亚甲基蓝染料中具有很强的活性,从染料降解的角度来看,氧化卤化铋材料在保护公众健康和环境方面具有很大的潜力。实验结果与非线性拟合吻合。
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引用次数: 0
Factors associated with research productivity in higher education institutions in Africa: a systematic review. 与非洲高等教育机构研究生产力相关的因素:一项系统综述。
Q2 Multidisciplinary Pub Date : 2022-01-28 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13211.2
Dieudonne Uwizeye, Florah Karimi, Caroline Thiong'o, Jackline Syonguvi, Vollan Ochieng, Francis Kiroro, Alex Gateri, Anne M Khisa, Hesborn Wao

Background: There are low levels of research productivity among Higher Education Institutions (HEIs) in Africa, a situation that is likely to compromise the development agenda of the continent if not addressed. We conducted a systematic literature review to synthesize evidence of the factors associated with research productivity in HEIs in Africa and the researchers' motives for research. Methods: We identified 838 publications related to research productivity in HEIs in Africa from various databases, from which we included 28 papers for review. The inclusion criteria were that (i) the paper's primary focus was on factors associated with research productivity, and motivations of doing research among faculty members in Africa; (ii) the setting was the HEIs in Africa; (iii) the type of publication was peer-reviewed papers and book chapters based on primary or secondary data analysis; and (iv) the language was English or French. Essays, opinions, blogs, editorials, reviews, and commentaries were excluded. Results: Most of the studies operationalized research productivity as either journal publications or conference proceedings. Both institutional and individual factors are associated with the level of research productivity in HEIs in Africa. Institutional factors include the availability of research funding, level of institutional networking, and the degree of research collaborations, while individual factors include personal motivation, academic qualifications, and research self-efficacy. Conclusions: Deliberate efforts in HEIs in Africa that addressed both individual and institutional barriers to research productivity are promising. This study recommends that the leadership of HEIs in Africa prioritizes the funding of research to enable researchers to contribute to the development agenda of the continent. Moreover, HEIs should build institutional support to research through the provision of research enabling environment, policies and incentives; strengthening of researchers' capabilities through relevant training courses, mentorship and coaching; and embracing networking and collaboration opportunities.

背景:非洲高等教育机构的研究生产力水平较低,如果不加以解决,这种情况可能会损害非洲大陆的发展议程。我们进行了一项系统的文献综述,以综合与非洲高等教育研究生产力相关的因素以及研究人员的研究动机的证据。方法:我们从各种数据库中确定了838篇与非洲高等教育机构研究生产力相关的出版物,其中包括28篇论文供审查。纳入标准是:(i)论文的主要关注点是与研究生产力相关的因素,以及非洲教员进行研究的动机;(ii)背景是非洲的高等教育机构;(iii)出版物的类型是基于初级或次级数据分析的同行评审论文和书籍章节;以及(iv)语言为英语或法语。论文、观点、博客、社论、评论和评论被排除在外。结果:大多数研究将研究生产力作为期刊出版物或会议记录。机构和个人因素都与非洲高等教育机构的研究生产力水平有关。制度因素包括研究资金的可用性、机构网络的水平和研究合作的程度,而个人因素包括个人动机、学历和研究自我效能。结论:非洲高等教育机构为解决研究生产力的个人和机构障碍所做的深思熟虑的努力是有希望的。这项研究建议,非洲高等教育机构的领导层优先考虑研究资金,使研究人员能够为非洲大陆的发展议程做出贡献。此外,高等教育机构应通过提供有利于研究的环境、政策和激励措施,建立对研究的机构支持;通过相关培训课程、指导和辅导加强研究人员的能力;拥抱网络和合作机会。
{"title":"Factors associated with research productivity in higher education institutions in Africa: a systematic review.","authors":"Dieudonne Uwizeye,&nbsp;Florah Karimi,&nbsp;Caroline Thiong'o,&nbsp;Jackline Syonguvi,&nbsp;Vollan Ochieng,&nbsp;Francis Kiroro,&nbsp;Alex Gateri,&nbsp;Anne M Khisa,&nbsp;Hesborn Wao","doi":"10.12688/aasopenres.13211.2","DOIUrl":"10.12688/aasopenres.13211.2","url":null,"abstract":"<p><p><b>Background</b>: There are low levels of research productivity among Higher Education Institutions (HEIs) in Africa, a situation that is likely to compromise the development agenda of the continent if not addressed. We conducted a systematic literature review to synthesize evidence of the factors associated with research productivity in HEIs in Africa and the researchers' motives for research. <b>Methods</b>: We identified 838 publications related to research productivity in HEIs in Africa from various databases, from which we included 28 papers for review. The inclusion criteria were that (i) the paper's primary focus was on factors associated with research productivity, and motivations of doing research among faculty members in Africa; (ii) the setting was the HEIs in Africa; (iii) the type of publication was peer-reviewed papers and book chapters based on primary or secondary data analysis; and (iv) the language was English or French. Essays, opinions, blogs, editorials, reviews, and commentaries were excluded. <b>Results</b>: Most of the studies operationalized research productivity as either journal publications or conference proceedings. Both institutional and individual factors are associated with the level of research productivity in HEIs in Africa. Institutional factors include the availability of research funding, level of institutional networking, and the degree of research collaborations, while individual factors include personal motivation, academic qualifications, and research self-efficacy. <b>Conclusions:</b> Deliberate efforts in HEIs in Africa that addressed both individual and institutional barriers to research productivity are promising. This study recommends that the leadership of HEIs in Africa prioritizes the funding of research to enable researchers to contribute to the development agenda of the continent. Moreover, HEIs should build institutional support to research through the provision of research enabling environment, policies and incentives; strengthening of researchers' capabilities through relevant training courses, mentorship and coaching; and embracing networking and collaboration opportunities.</p>","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311799.2/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39760582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Competency-based Training Needs Assessment for Research Managers and Administrators in Africa and the United Kingdom to Strengthen Equitable Partnerships. 非洲和联合王国研究经理和行政人员以能力为基础的培训需求评估,以加强公平的伙伴关系。
Q2 Multidisciplinary Pub Date : 2022-01-01 DOI: 10.12688/aasopenres.13272.1
Victoria Nembaware, Simon Glasser, Anne Priest, Ailsa Davies, Michelle Skelton, Paidamoyo Bodzo, Olivia Lelong, Alecia Naidu, Colleen Masimirembwa, Alice Mutambiranwa, Annette Hay, Ambroise Wonkam, Collet Dandara

Background: The need for competent research managers and administrators (RMAs) has increased due to the complexity in managing research projects between disparate and international partners. To facilitate the creation of robust training and professional development programmes it is essential to first understand the status quo. A collaborative project, Sustainable Management and Administration for Research: Training across the project Lifecycle (SMARTLife), made up of RMAs from South Africa, Zimbabwe and the United Kingdom (UK) developed a set of competencies to conduct an RMA competency-based training needs assessment scoping tool. Method: Nine areas were identified: Equitable partnership; Finance Management; Project Management; Monitoring and Evaluation; Reporting and Communications; Equity, Diversity & Inclusion; Training and Capacity Development; Impact a& Sustainability; and Ethical, Social, Legal a& Social Implications.  Tasks for each competency area were identified to develop an scoping tool that had 168 data collection points. The tool was advertised through press releases, mailing lists and social media. Results:  108 responses were obtained:  with 49% from 15 Africa countries/the remainder from the UK. The UK (71%) had more permanent RMA staff members compared to Africa (39%). There were more respondents in Africa with the title of Research Manager/Coordinator(p=0.0132) compared to the UK where most of the RMAs were employed as Finance/Contract officers. 60% of respondents from the UK had more than three years experience while only 35% from Africa had experience. While most RMAs had formal higher education qualifications, their training was not in research management and administration, which requires a diverse range of skills. Confidence in specific tasks varied between the UK and Africa whereas collaborative partnerships challenges and enablers were similar. Conclusion This work highlights differences in RMA training and experience RMA  between Africa and UK, this work could inform much needed competency-based training for RMAs and partnership strategies that aid mutual-learning.

背景:由于管理不同和国际合作伙伴之间的研究项目的复杂性,对有能力的研究经理和管理员(rma)的需求增加了。为了促进建立强有力的培训和专业发展方案,首先必须了解现状。由来自南非、津巴布韦和英国的军事军事管理局组成的合作项目“研究的可持续管理和管理:跨项目生命周期的培训”(SMARTLife)开发了一套能力,用于开展基于军事军事管理局能力的培训需求评估范围界定工具。方法:确定了九个领域:公平伙伴关系;财务管理;项目管理;监测和评价;报告和通讯;公平、多元化和包容性;培训和能力发展;影响与可持续性;以及伦理、社会、法律和社会影响。确定了每个能力领域的任务,以开发具有168个数据收集点的范围界定工具。该工具通过新闻稿、邮件列表和社交媒体进行宣传。结果:获得108份回复:其中49%来自15个非洲国家/其余来自英国。与非洲(39%)相比,英国(71%)拥有更多的永久军事革命工作人员。与英国相比,非洲拥有研究经理/协调员头衔的受访者更多(p=0.0132),而英国的大多数rma被聘为财务/合同官员。60%的英国受访者有三年以上的工作经验,而只有35%的非洲受访者有工作经验。虽然大多数军事专家都有正规的高等教育资格,但他们的培训并不是在研究管理和行政方面,这需要各种各样的技能。英国和非洲对具体任务的信心有所不同,而合作伙伴关系的挑战和推动因素是相似的。这项工作突出了非洲和英国在军事革命培训和经验方面的差异,这项工作可以为军事革命提供急需的基于能力的培训和有助于相互学习的伙伴关系战略。
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引用次数: 0
Self-management and its associated factors among people living with diabetes in Blantyre, Malawi: a cross-sectional study.
Q2 Multidisciplinary Pub Date : 2021-12-23 eCollection Date: 2019-01-01 DOI: 10.12688/aasopenres.12992.2
Chimwemwe Kwanjo Banda, Belinda T Gombachika, Moffat J Nyirenda, Adamson Sinjani Muula

Background: Self-management is key to the control of glycaemia and prevention of complications in people with diabetes. Many people with diabetes in Malawi have poorly controlled glucose and they experience diabetes-related complications. This study aimed to assess diabetes self-management behaviours and to identify factors associated with it among people with diabetes at Queen Elizabeth Central Hospital, Blantyre, Malawi. Methods: This cross-sectional study recruited 510 adults attending a diabetes clinic at a teaching referral hospital in southern Malawi. The social cognitive theory was applied to identify factors associated with following all recommended self-management behaviours. Data on participants' demographics, clinical history, diabetes knowledge, self-efficacy, outcome expectations, social support, environmental barriers and diabetes self-management were collected. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with following all self-management behaviours. Results: The mean age of participants was 53.6 (SD 13.3) years. The majority (82%) were females. Self-reported medication adherence within the last seven days was 88.6%; 77% reported being physically active for at least 30 minutes on more than three days in the previous seven days; 69% reported checking their feet every day and inspecting inside their shoes; 58% reported following a healthy diet regularly. Only 33% reported following all the self-management behaviours regularly. Multiple logistic regression analysis showed that self-efficacy was the only social cognitive factor associated with following all the self-management practices (p < 0.001). Conclusions: Participants in our study were not consistently achieving all self-management practices with dietary practices being the least adhered to behaviour by many. To improve self-management practices of people with diabetes, current health education programs should not only aim at improving diabetes related knowledge but also self-efficacy. Adopting interventions that promote self-efficacy in diabetes patients such as exposure to role models, peer education, providing positive feedback, and counselling is recommended.

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引用次数: 0
A mapping of health education institutions and programs in the WHO African Region. 世卫组织非洲区域卫生教育机构和规划地图
Q2 Multidisciplinary Pub Date : 2021-12-14 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13320.1
Aaron N Yarmoshuk, Pierre Abomo, Niamh Fitzgerald, Donald C Cole, Arnaud Fontanet, Henry A Adeola, Christina Zarowsky, Justin Pulford

Background: Information on health education institutions is required for planning, implementing and monitoring human resources for health strategies. Details on the number, type and distribution of medical and health science programs offered by African higher education institutions remains scattered. Methods: We merged and updated datasets of health professional and post-graduate programs to develop a mapping of health education institutions covering the World Health Organization African Region as of 2021. Results: Nine hundred and nine (909) institutions were identified in the 47 countries. Together they offered 1,157 health professional programs (235 medicine, 718 nursing, 77 public health and 146 pharmacy) and 1,674 post-graduate programs (42 certificates, 1,152 Master's and 480 PhDs). Regionally, East Africa had the most countries with multiple academic health science centres - institutions offering medical degrees and at least one other health professional program. Among countries, South Africa had the most institutions and post-graduate programs with 182 and 596, respectfully. A further five countries had between 53-105 institutions, 12 countries had between 10 and 37 institutions, and 28 countries had between one and eight institutions. One country had no institution. Countries with the largest populations and gross domestic products had significantly more health education institutions and produced more scientific research (ANOVA testing). Discussion: We envision an online database being made available in a visually attractive, user-friendly, open access format that nationally, registered institutions can add to and update. This would serve the needs of trainees, administrators, planners and researchers alike and support the World Health Organization's Global strategy on human resources for health: workforce 2030.

背景:规划、实施和监测卫生战略人力资源需要有关卫生教育机构的信息。关于非洲高等教育机构提供的医学和健康科学项目的数量、类型和分布的详细信息仍然零散。方法:我们合并并更新了卫生专业人员和研究生项目的数据集,以绘制截至2021年世界卫生组织非洲地区卫生教育机构的地图。结果:在47个国家中确定了909个机构。他们总共提供了1157个健康专业项目(235个医学、718个护理、77个公共卫生和146个药学)和1674个研究生项目(42个证书、1152个硕士和480个博士)。从地区来看,东非拥有多个学术健康科学中心的国家最多,这些中心提供医学学位和至少一个其他健康专业项目。在国家中,南非拥有最多的机构和研究生项目,分别为182个和596个。另有5个国家拥有53-105个机构,12个国家拥有10至37个机构,28个国家拥有1至8个机构。一个国家没有机构。人口和国内生产总值最多的国家拥有更多的健康教育机构,开展了更多的科学研究(方差分析测试)。讨论:我们设想以一种视觉吸引力、用户友好、开放访问的形式提供一个在线数据库,全国注册机构可以添加和更新该数据库。这将满足受训人员、管理人员、规划者和研究人员的需求,并支持世界卫生组织关于卫生人力资源的全球战略:2030年劳动力。
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引用次数: 0
Gene expression changes in mammalian hosts during schistosomiasis: a review 血吸虫病期间哺乳动物宿主基因表达的变化
Q2 Multidisciplinary Pub Date : 2021-11-23 DOI: 10.12688/aasopenres.13312.1
J. Namulondo, J. Mulindwa, O. Nyangiri, Moses Egesa, H. Noyes, E. Matovu
Schistosomiasis affects over 250 million people worldwide with an estimated mortality of more than 200,000 deaths per year in sub-Saharan Africa. Efforts to control schistosomiasis in the affected areas have mainly relied on mass administration of praziquantel, which kills adult but not immature worms of all Schistosoma species. Mammalian hosts respond differently to Schistosoma infection with some being more susceptible than others, which is associated with risk factors such as sociodemographic, epidemiological, immunological and/or genetic. Host genetic factors play a major role in influencing molecular processes in response to schistosomiasis as shown in gene expression studies. These studies highlight gene profiles expressed at different time points of infection using model animals. Immune function related genes; cytokines (Th1 and Th17) are upregulated earlier in infection and Th2 upregulated later indicating a mixed Th1/Th2 response. However, Th1 response has been shown to be sustained in S. japonicum infection. Immune mediators such as matrix metalloproteinases (Mmps) and tissue inhibitors of matrix metalloproteinases (Timps) are expressed later in the infection and these are linked to wound healing and fibrosis. Downregulation of metabolic associated genes is recorded in later stages of infection. Most mammalian host gene expression studies have been done using rodent models, with fewer in larger hosts such as bovines and humans. The majority of these studies have focused on S. japonicum infections and less on S. haematobium and S. mansoni infections (the two species that cause most global infections). The few human schistosomiasis gene expression studies so far have focused on S. japonicum and S. haematobium infections and none on S. mansoni, as far as we are aware. This highlights a paucity of gene expression data in humans, specifically with S. mansoni infection. This data is important to understand the disease pathology, identify biomarkers, diagnostics and possible drug targets.
血吸虫病影响着全世界超过2.5亿人,撒哈拉以南非洲每年的死亡率估计超过20万。在受影响地区控制血吸虫病的努力主要依靠大规模施用吡喹酮,吡喹酮可以杀死所有血吸虫物种的成年但非未成熟蠕虫。哺乳动物宿主对血吸虫感染的反应不同,其中一些宿主比其他宿主更容易感染,这与社会人口学、流行病学、免疫学和/或遗传等风险因素有关。基因表达研究表明,宿主遗传因素在影响血吸虫病反应的分子过程中发挥着重要作用。这些研究强调了使用模型动物在感染的不同时间点表达的基因图谱。免疫功能相关基因;细胞因子(Th1和Th17)在感染早期上调,而Th2在感染后期上调。然而,Th1反应已被证明在日本血吸虫感染中是持续的。免疫介质如基质金属蛋白酶(Mmps)和基质金属蛋白酶组织抑制剂(Timps)在感染后期表达,这些与伤口愈合和纤维化有关。代谢相关基因的下调记录在感染的后期阶段。大多数哺乳动物宿主基因表达研究都是使用啮齿动物模型进行的,在牛和人类等较大宿主中的研究较少。这些研究大多集中在日本血吸虫感染上,较少关注埃及血吸虫和曼氏血吸虫感染(这两个物种导致全球感染最多)。到目前为止,为数不多的人类血吸虫病基因表达研究集中在日本血吸虫和埃及血吸虫感染上,而据我们所知,没有一项研究集中在曼氏血吸虫上。这突出了人类基因表达数据的匮乏,特别是曼氏梭形杆菌感染。这些数据对于了解疾病病理、识别生物标志物、诊断和可能的药物靶点非常重要。
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引用次数: 1
Associations between sexual orientation, financial security and relationships with family and peers during the COVID-19 pandemic in Nigeria 尼日利亚新冠肺炎大流行期间性取向、经济保障以及与家人和同龄人的关系之间的关联
Q2 Multidisciplinary Pub Date : 2021-11-09 DOI: 10.12688/aasopenres.13296.1
M. Foláyan, O. Ibigbami, Nourhan M. Aly, R. A. A. Zuñiga, G. Abeldaño, Eshrat Ara, Passent Ellakany, I. Idigbe, A. Ishabiyi, M. Jafer, Abeedah Tu-Allah Khan, Zumama Khalid, F. Lawal, J. Lusher, N. Nzimande, B. Popoola, Mir Furruq Ali Quadri, Mark Y. Roque, J. Okeibunor, B. Brown, A. Nguyen
Background: This study aimed to determine whether factors associated with financial insecurity during the COVID-19 pandemic were associated with worsening relationships with family, peers and friends of sexual minorities living in Nigeria. Methods: Data were collected using an online survey conducted from 29th June to 31st December 2020. The outcome variable was the quality of relationship with family, friends and peers during the COVID-19 pandemic. The explanatory variables were the sexual orientation (lesbian, gay, bisexual, heterosexual), COVID-19 status, and financial security (job loss or reduced/lost wages because of the COVID-19 pandemic). Multilevel logistic regression analysis models with robust estimation were built and used to assess the association between the outcome and explanatory variables. The models were adjusted for sociodemographic profile (age, sex at birth, education status). Results: Being a sexual minority was associated with higher odds of worsened relationship with family (AOR: 1.49) and friends and peers (AOR: 2.38) during the pandemic. Having COVID-19 symptoms but not getting tested was significantly associated with higher odds of reporting worsening of the relationship with family (AOR: 1.69) and history of job loss (AOR: 1.68), while having formal education (p<0.05) was significantly associated with lower odds of reporting worsening of the relationship with family. The factors significantly associated with higher odds of reporting worsened relationship with friends and peers were testing positive for COVID-19 (AOR: 1.60), reduced wages (AOR: 1.24), and being older (AOR: 1.01). Attaining a college/university education was significantly associated with lower odds of worsened relationship with friends and peers (AOR: 0.31). Conclusions: The COVID-19 pandemic may increase the risk of negative disruptions in the relationships with family, friends and peers, especially for sexual minorities. National COVID-19 response programs should include plans to support those who face social disruption in managing the crisis.
背景:本研究旨在确定新冠肺炎大流行期间与财务不安全相关的因素是否与居住在尼日利亚的性少数群体的家人、同龄人和朋友关系恶化有关。方法:使用2020年6月29日至12月31日进行的在线调查收集数据。结果变量是新冠肺炎大流行期间与家人、朋友和同龄人的关系质量。解释变量是性取向(女同性恋、男同性恋、双性恋、异性恋)、新冠肺炎状况和经济保障(新冠肺炎大流行导致的失业或工资减少/损失)。建立了具有稳健估计的多级逻辑回归分析模型,并用于评估结果与解释变量之间的相关性。模型根据社会人口特征(年龄、出生性别、教育状况)进行了调整。结果:在疫情期间,性少数群体与家人(AOR:1.49)、朋友和同龄人(AOR:2.38)关系恶化的几率更高。有新冠肺炎症状但未接受检测与报告与家庭关系恶化的几率较高(AOR:1.69)和有失业史(AOR+1.68)显著相关,而接受正规教育(p<0.05)与报告与家人关系恶化的可能性较低显著相关。与报告与朋友和同龄人关系恶化的可能性较高显著相关的因素是新冠肺炎检测呈阳性(AOR:1.60)、工资降低(AOR:12.4)、,以及年龄较大(AOR:1.01)。接受大学/学院教育与与朋友和同龄人关系恶化的几率较低显著相关(AOR:0.31)。结论:新冠肺炎大流行可能会增加与家人、朋友和同龄人的关系受到负面干扰的风险,尤其是对性少数群体而言。国家新冠肺炎应对计划应包括支持那些面临社会混乱的人管理危机的计划。
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引用次数: 0
Community-level influences on women's experience of intimate partner violence and modern contraceptive use in Nigeria: a multilevel analysis of nationally representative survey. 尼日利亚社区层面对妇女遭受亲密伴侣暴力和使用现代避孕药具的影响:对全国代表性调查的多层次分析。
Q2 Multidisciplinary Pub Date : 2021-11-08 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13247.2
Sunday A Adedini, Ololade Grace Adewole, Funmilola F Oyinlola, Olufunke Fayehun

Background : Modern contraceptives (MC) are important strategies for reducing unwanted pregnancies, unsafe abortion and maternal mortality, but MC remains low at 18% in Nigeria. Similarly, while there is increasing prevalence of intimate partner violence (IPV) in Nigeria, its effects on contraceptive use remain unclear. This study examined the influence of IPV on MC use, while adjusting for individual- and community-level confounders. Methods : The study utilized 2018 Nigeria Demographic and Health Survey data. We performed multilevel binary logistic regression analysis on 24,973 married women aged 15-49 49 (nested within 1,400 communities), who were sexually active and were not pregnant at the time of the survey. Results : Findings show that use of MC was higher among married women who reported experience of IPV than those without IPV exposure. After adjusting for individual-level and contextual factors, the odds of using MC was significantly higher among women who experienced any form of IPV (OR: 1.61, 95% CI: 1.17-2.21, p<0.005) compared to those who reported no IPV experience. Around one-quarter of the total variance in contraceptive use with respect to the different types of IPV could be explained at the community level. Conclusion : The study provides empirical evidence that there is significant community effect on IPV exposure and women's contraceptive uptake. Attention must therefore be given to the context-specific social and gender norms that affect women's sexual and reproductive health in Nigeria.

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引用次数: 0
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