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2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)最新文献

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Gastric Location Classification During Esophagogastroduodenoscopy Using Deep Neural Networks 基于深度神经网络的食管胃十二指肠镜胃定位分类
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635273
A. Ding, Ying Li, Qilei Chen, Yu Cao, Benyuan Liu, Shu Han Chen, Xiaowei Liu
Esophagogastroduodenoscopy (EGD) is a common procedure that visualizes the esophagus, stomach, and the duodenum by inserting a camera, attached to a long flexible tube, into the patient's mouth and down the stomach. A comprehensive EGD needs to examine all gastric locations, but since the camera is controlled manually, it is easy to miss some surface area and create diagnostic blind spots, which often result in life-costing oversights of early gastric cancer and other serious illnesses. In order to address this problem, we train a convolutional neural network to classify gastric locations based on the camera feed during an EGD, and based on the classifier and a triggering algorithm we propose, we build a video processing system that checks off each location as visited, allowing human operators to keep track of which locations they have visited and which they have not. Based on collected clinical patient reports, we consider six gastric locations, and we add a background class to our classifier to accomodate for the frames in EGD videos that do not resemble the six defined classes (including when the camera is outside of the patient body). Our best classifier achieves 98 % accuracy within the six gastric locations and 88 % accuracy including the background class, and our video processing system clearly checks off gastric locations in an expected order when being tested on recorded EGD videos. Lastly, we use class activation mapping to provide human-readable insight into how our trained classifier works.
食管胃十二指肠镜检查(EGD)是一种常见的检查方法,通过将连接在一根长柔性管上的照相机插入患者的口腔并沿着胃向下,观察食管、胃和十二指肠。全面的EGD需要检查胃的所有部位,但由于相机是手动控制的,很容易错过一些表面区域并产生诊断盲点,这往往导致对早期胃癌和其他严重疾病的疏忽,导致生命损失。为了解决这个问题,我们训练了一个卷积神经网络,根据EGD期间的摄像机馈送对胃的位置进行分类,并基于我们提出的分类器和触发算法,我们建立了一个视频处理系统,检查每个访问过的位置,允许人类操作员跟踪他们访问过的位置和没有访问过的位置。根据收集到的临床患者报告,我们考虑了六个胃位置,并在分类器中添加了一个背景类,以适应EGD视频中与六个定义类不相似的帧(包括当摄像机在患者身体外时)。我们最好的分类器在六个胃位置内达到98%的准确率,包括背景类在内达到88%的准确率,我们的视频处理系统在录制的EGD视频上进行测试时,可以按照预期的顺序清楚地检查胃位置。最后,我们使用类激活映射来提供对训练过的分类器如何工作的人类可读的洞察。
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引用次数: 4
Sparse Graph-based Representations of SSVEP Responses Under the Variational Bayesian Framework 变分贝叶斯框架下基于稀疏图的SSVEP响应表示
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635427
V. Oikonomou, S. Nikolopoulos, Y. Kompatsiaris
The recognition of Steady State Visual Evoked Potentials (SSVEP) constitutes a challenging problem in Brain Computer Interfaces (BCI), especially when the number of EEG sensors is limited. In this work, we propose a new sparse representation classification scheme that extends current schemes by exploiting the graph properties of relevant features. Based on this scheme each test signal is represented as a linear combination of train signals. Our expectation is that this constrained linear combination, exploiting the graph's structure of the training data, will lead to representations that are more robust. Moreover, in order to avoid overfitting and provide a model with good generalization abilities we adopt the bayesian framework and, in particular, the Variational Bayesian Framework since we use a specific prior distribution to exploit the graph structure of the data. The proposed algorithm has been evaluated on two SSVEP datasets achieving state-of- the-art performance against well known classification methods in SSVEP literature.
稳态视觉诱发电位(SSVEP)的识别是脑机接口(BCI)中一个具有挑战性的问题,特别是在脑电信号传感器数量有限的情况下。在这项工作中,我们提出了一种新的稀疏表示分类方案,该方案通过利用相关特征的图属性来扩展现有方案。基于该方案,每个测试信号被表示为列车信号的线性组合。我们的期望是,这种约束的线性组合,利用训练数据的图结构,将导致更鲁棒的表示。此外,为了避免过拟合并提供具有良好泛化能力的模型,我们采用贝叶斯框架,特别是变分贝叶斯框架,因为我们使用特定的先验分布来利用数据的图结构。所提出的算法已经在两个SSVEP数据集上进行了评估,在SSVEP文献中,与已知的分类方法相比,该算法达到了最先进的性能。
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引用次数: 2
Heart Rate Classification Using ECG Signal Processing and Machine Learning Methods 基于心电信号处理和机器学习方法的心率分类
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635462
M. Papadogiorgaki, M. Venianaki, Paulos Charonyktakis, M. Antonakakis, I. Tsamardinos, M. Zervakis, V. Sakkalis
Electrocardiogram (ECG) signal constitutes a valuable technique that provides considerable information towards the early diagnosis of several cardiovascular diseases, especially regarding the detection of abnormal heart rate, namely arrhythmias. In this paper, innovative methodologies that allow for the efficient classification of cardiac rhythm are presented. The proposed methods are based on ECG signal analysis, extraction of significant features, as well as classification algorithms. Several clinical, time- and frequency-domain features are either calculated, or automatically extracted by means of a Convolutional Neural Network, while traditional machine learning algorithms, such as k-Nearest Neighbors and Random Forests are employed in order to classify the ECG signals among 7 different cases of abnormal and normal heart rate. The learning methods are carried out within the JADBio software tool, that also performs feature selection prior to classification. The experimental results demonstrate high performance of the deployed methods in terms of relevant statistical metrics, while they yielded an average validation Area Under the Curve (AUC) of 99.9%.
心电图(ECG)信号是一种有价值的技术,它为几种心血管疾病的早期诊断提供了大量信息,特别是在检测异常心率(即心律失常)方面。在本文中,创新的方法,允许心律的有效分类提出。所提出的方法是基于心电信号分析、显著特征提取和分类算法。通过卷积神经网络计算或自动提取多个临床、时间和频域特征,同时使用传统的机器学习算法,如k近邻和随机森林,对7种不同的心率异常和正常病例的心电信号进行分类。学习方法是在JADBio软件工具中进行的,该工具也在分类之前执行特征选择。实验结果表明,所部署的方法在相关统计指标方面具有很高的性能,而它们的平均验证曲线下面积(AUC)为99.9%。
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引用次数: 5
Analyzing the Impact of Resampling Approaches on Chest X-Ray Images for COVID-19 Identification in a Local Hierarchical Classification Scenario 局部分层分类场景下重采样方法对胸部x线图像COVID-19识别的影响分析
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635433
F. K. H. D. Barros, André L. Jeller Selleti, Vinicius Queiroz, R. M. Pereira, C. Silla
Researchers dealing with real-world data - such as in the healthcare domain - tend to face class imbalance issues. More specifically, publicly available datasets containing Chest X-Ray (CXR) of Pneumonia diseases (including COVID-19) usually have an imbalanced class distribution. This dataset imbalance causes automatic diagnosis systems to classify majority classes with much more accuracy than the minority ones. Several resampling algorithms were proposed in the past to deal with the class imbalance issue. Hierarchical classifiers have also been proposed to increase the predictive performance of classifiers, but there is little research in the literature verifying if using existing resampling algorithms with hierarchical classifiers are a good alternative to improve classification performance. This work proposes an experimental classification schema to investigate the effectiveness of using resampling algorithms in the identification of COVID-19 and other types of Pneumonia through CXR images. The proposed schema uses resampling algorithms to rebalance the class distribution, in a Local Hierarchical Classification scenario. The experimental evaluation, which is supported by inferential statistical analysis, showed that using specific resampling algorithms with Local Hierarchical Classifiers brings a statistically significant increase to the macro-averaged Fl-Score, and improves the predictive performance for the minority classes.
处理现实世界数据的研究人员——比如在医疗保健领域——往往面临着阶级不平衡的问题。更具体地说,包含肺炎疾病(包括COVID-19)的胸部x射线(CXR)的公开可用数据集通常具有不平衡的类别分布。这种数据不平衡导致自动诊断系统对多数类的分类比少数类的分类准确率高得多。过去提出了几种重采样算法来处理类不平衡问题。层次分类器也被提出用于提高分类器的预测性能,但文献中很少有研究验证使用现有的重采样算法与层次分类器是否是提高分类性能的一个很好的选择。本文提出了一种实验分类模式,以研究利用重采样算法通过CXR图像识别COVID-19和其他类型肺炎的有效性。在局部分层分类场景中,提出的模式使用重采样算法来重新平衡类分布。实验评估结果表明,采用局部分层分类器的特定重采样算法可以显著提高宏观平均Fl-Score,并提高对少数类别的预测性能。
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引用次数: 0
Theory and Parameterization of Infections and Waves by Covid-19: A 6-Countries Data Analysis Covid-19感染和波的理论和参数化:一项6国数据分析
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635536
H. Nieto-Chaupis
From data of USA, Japan, Germany, UK, Italy and Russian, it is claimed that the Global pandemic dictated by the dynamics of Corona virus exhibits distributions that would correspond to a morphology of Bessel-like type. Under the assumption that the pandemic contains phases of infection denoted by the velocity and acceleration of propagation of virus, then a model of polynomials given by the integer-order Bessel functions is proposed. These polynomials enter in a statistical approach to define the law of infections as function of time for the ongoing global pandemic. From this, the data evolution and their different behaviors are interpreted in terms of the different phases including the Delta variant for the recent months until August 2021.
从美国、日本、德国、英国、意大利和俄罗斯的数据来看,由冠状病毒动态决定的全球大流行表现出与贝塞尔样形态相对应的分布。在假定大流行包含以病毒传播速度和加速度表示的感染阶段的前提下,提出了由整阶贝塞尔函数给出的多项式模型。这些多项式进入统计方法,以确定感染规律作为持续全球大流行的时间函数。据此,根据近几个月至2021年8月的不同阶段(包括Delta变量)来解释数据演变及其不同行为。
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引用次数: 2
CareKeeper: A Platform for Intelligent Care Coordination CareKeeper:智能护理协调平台
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635445
H. Kondylakis, Dimitrios G. Katehakis, A. Kouroubali, K. Marias, G. Flouris, Theodoros Patkos, I. Fundulaki, D. Plexousakis
Informal care is fundamental in the wellbeing and resilience of elderly and people with chronic conditions. However, solutions for the effective collaboration of healthcare professionals, patients and informal carers are not yet widely available. CareKeeper builds on a state-of-the-art personal health system, augmenting it with Artificial Intelligence and Big Data technologies, to boost informal care coordination. In this paper we report on the design of the platform with the aim of providing a light-weighted communication solution to support practical challenges about sharing the responsibility of caring, such as the frequency of visits, support to routinely activities and timely intervention in case of emergency and need.
非正式护理对老年人和慢性病患者的福祉和复原力至关重要。然而,医疗保健专业人员、患者和非正式护理人员之间有效合作的解决方案尚未广泛使用。CareKeeper以最先进的个人卫生系统为基础,利用人工智能和大数据技术对其进行增强,以促进非正式护理协调。在本文中,我们报告了该平台的设计,旨在提供一个轻量级的通信解决方案,以支持分享关怀责任的实际挑战,例如访问频率,对日常活动的支持以及在紧急情况和需要时的及时干预。
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引用次数: 2
Epidemiological forecasting of COVID-19 infection using deep learning approach 基于深度学习方法的COVID-19感染流行病学预测
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635289
A. Blagojević, T. Šušteršič, Nenad Filipović
Since the novel SARS-CoV-2 virus appeared, interest in developing epidemiological mechanisms that would help in prevention of its spread has increased. Epidemiological models are the most important mechanisms for examining the spread of the virus. For that purpose, we propose deep learning approach, LSTM neural network model. LSTM is a special kind of neural network structure capable of learning long-term dependencies in sequence prediction problems. The model was fed with official statistical data available online for Belgium in the period of March 15th, 2020 to March 15th, 2021. Results show that LSTM is capable of predicting in long-term manner with the low values of RMSE and MAE. Higher values of RMSE and MAE are observed in the infected cases (RMSE was 397.23 and MAE was 315.35) which is expected due to thousands of infected people per day in Belgium. In future studies, we will include more phenomena, especially medical intervention and asymptomatic infection, in order to better describe the COVID-19 spread and development.
自新型SARS-CoV-2病毒出现以来,人们对开发有助于预防其传播的流行病学机制的兴趣有所增加。流行病学模型是检验病毒传播的最重要机制。为此,我们提出了深度学习方法,LSTM神经网络模型。LSTM是一种特殊的神经网络结构,能够学习序列预测问题中的长期依赖关系。该模型使用了比利时2020年3月15日至2021年3月15日期间的在线官方统计数据。结果表明,LSTM具有较低的RMSE和MAE值,具有较好的长期预测能力。在感染病例中观察到较高的RMSE和MAE值(RMSE为397.23,MAE为315.35),由于比利时每天有数千人感染,预计这一数值会更高。在未来的研究中,我们将纳入更多的现象,特别是医疗干预和无症状感染,以便更好地描述COVID-19的传播和发展。
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引用次数: 0
Autoencoder-based bone removal algorithm from x-ray images of the lung 基于自编码器的肺x线图像去骨算法
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635451
Seweryn Kalisz, M. Marczyk
The application of machine learning methods in biomedical image analysis has recently become of particular interest to researchers. One of the most common diagnostic methods with low cost and high availability is X-ray imaging. It allows the acquisition of frontal images of the chest, which can be used in the medical diagnosis of various diseases and prognosis. Due to the presence of ribs on the image, some pathologic changes may go unnoticed. The goal of this work is to develop a method, using deep learning techniques, to remove ribs from chest X-ray images. The Bone Suppression dataset, consisting of 35 pairs of standard X-ray and soft-tissue only images, was used to develop the model. COVIDx was used as an external test set. Due to the small number of images in the training cohort, a data augmentation technique was used to generate new, noisy image pairs. A deep learning model using convolutional denoising autoencoder architecture was developed to remove the ribs from the X-ray image. The effects of two image down-sampling methods and learning rate changes were evaluated. The resulting images are characterized by partial or complete suppression of the ribs. It should be noted that the problem was not posed by images of patients suffering from COVID-19, which are characterized by much more complex structures.
机器学习方法在生物医学图像分析中的应用最近成为研究人员特别感兴趣的问题。最常见的诊断方法之一是x射线成像,成本低,可用性高。它可以获取胸部的正面图像,可用于各种疾病的医学诊断和预后。由于图像上有肋骨的存在,一些病理变化可能会被忽视。这项工作的目标是开发一种方法,使用深度学习技术,从胸部x光图像中去除肋骨。骨抑制数据集由35对标准x射线和软组织图像组成,用于开发模型。冠状病毒作为外部测试集。由于训练队列中的图像数量较少,因此使用数据增强技术来生成新的噪声图像对。开发了一种基于卷积去噪自编码器架构的深度学习模型,用于去除x射线图像中的肋骨。评估了两种图像降采样方法的效果和学习率的变化。结果图像的特点是部分或完全抑制肋骨。应该指出的是,这个问题不是由COVID-19患者的图像引起的,这些图像的特征是结构复杂得多。
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引用次数: 0
Calculation of blood flow in carotid artery bifurcation by turbulent finite element method 用湍流有限元法计算颈动脉分叉处的血流
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635360
A. Nikolic, M. Topalovic, V. Simić, N. Filipovic
Calculation of turbulent fluid flow in this paper is performed using two-equation turbulent finite element model that can calculate values in the viscous sublayer. Implicit integration of the equations is used for determining the fluid velocity, pressure, turbulence, kinetic energy, and dissipation of turbulent kinetic energy. These values are calculated in the finite element nodes for each step of incremental-iterative procedure. Developed turbulent finite element model with the customized generation of finite element meshes is used for solving complex blood flow problems. FEM Analysis results for the artery geometry of the selected anonymous patient provides us with data about important hemodynamics parameters such are blood velocity field and wall shear stress. Cardiologists could use proposed tools and methods to supplement clinical investigation of the hemodynamic conditions inside bifurcation of arteries.
本文的紊流流动计算采用双方程紊流有限元模型,该模型可以计算粘性亚层内的数值。方程的隐式积分用于确定流体的速度、压力、湍流、动能和湍流动能的耗散。这些值是在增量迭代法每一步的有限元节点中计算出来的。建立了湍流有限元模型,并定制生成有限元网格,用于求解复杂的血流问题。所选匿名患者的动脉几何形状有限元分析结果为我们提供了重要的血流动力学参数,如血流速度场和壁剪切应力的数据。心脏病专家可以使用建议的工具和方法来补充动脉分叉内血流动力学状况的临床研究。
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引用次数: 0
Free radical scavenger capacity of 1,2,5-trihydroxyanthraquinone and 1,2,5-trihydroxythioxanthone: a theoretical comparative study 1,2,5-三羟基蒽醌与1,2,5-三羟基硫氧蒽酮自由基清除能力的理论比较研究
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635259
S. Jeremic, M. S. Pirkovic, Jelena Đorović Jovanović, Z. Marković
In this contribution are estimated and compared free radical scavenger capacity of 1,2,5- trihydroxyanthraquinone (AN) and 1,2,5-trihydroxythioxanthone (TX). For this purpose, $mathbf{M06}-mathbf{2X/6}-311++mathbf{G}(mathbf{d, p})$ method is used. Scavenger capacities of both molecules are determined in benzene and water. It is found that both antioxidants generate stable radicals in water following SPLET mechanism. On the other hand, the most plausible mechanism for that purpose in benzene is HAT. In the presence of three selected free radicals $(mathbf{HO}^{bullet},mathbf{HOO}^{bullet}mathbf{and} mathbf{CH_{3}OO}^{bullet})$ these molecules manifest their scavenger capacity following HAT and SPLET competitively in both estimated environment conditions. The reactivity of observed molecules toward free radicals decreases following the order: $mathbf{HO}^{bullet}ggmathbf{HOO}^{bullet}>mathbf{CH_{3}OO}^{bullet}$. Comparing thermodynamic parameters that describe homolytic O-H cleavage for estimated antioxidants, it is concluded that TX shows somewhat higher scavenger capacity.
在此贡献估计和比较了1,2,5-三羟基蒽醌(AN)和1,2,5-三羟基硫氧蒽酮(TX)的自由基清除能力。为此,使用$mathbf{M06}-mathbf{2X/6}-311++mathbf{G}(mathbf{d, p})$方法。这两种分子在苯和水中的清除能力是确定的。研究发现,这两种抗氧化剂均通过SPLET机制在水中产生稳定的自由基。另一方面,在苯中达到这个目的的最合理的机制是HAT。在三个选定的自由基$(mathbf{HO}^{bullet},mathbf{HOO}^{bullet}mathbf{和} mathbf{CH_{3}OO}^{bullet})$的存在下,这些分子在HAT和SPLET两种估计的环境条件下竞争性地表现出它们的清除能力。观察到的分子对自由基的反应活性依次递减:$mathbf{HO}^{bullet}ggmathbf{HOO}^{bullet}>mathbf{CH_{3}OO}^{bullet}$。比较了描述氧化氢均裂的热力学参数,得出了TX具有较高的清除能力的结论。
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引用次数: 0
期刊
2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)
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