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2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)最新文献

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Cognitive workload level estimation based on eye tracking: A machine learning approach 基于眼动追踪的认知工作量水平估计:一种机器学习方法
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635166
Vasileios Skaramagkas, Emmanouil Ktistakis, D. Manousos, N. Tachos, E. Kazantzaki, E. Tripoliti, D. Fotiadis, M. Tsiknakis
Cognitive workload is a critical feature in related psychology, ergonomics, and human factors for understanding performance. However, it still is difficult to describe and thus, to measure it. Since there is no single sensor that can give a full understanding of workload, extended research has been conducted in order to present robust biomarkers. During the last years, machine learning techniques have been used to predict cognitive workload based on various features. Gaze extracted features, such as pupil size, blink activity and saccadic measures, have been used as predictors. The aim of this study is to use gaze extracted features as the only predictors of cognitive workload. Two factors were investigated: time pressure and multi tasking. The findings of this study showed that eye and gaze features are useful indicators of cognitive workload levels, reaching up to 88% accuracy.
认知负荷是相关心理学、工效学和理解工作表现的人为因素的一个重要特征。然而,它仍然很难描述,因此,测量它。由于没有单一的传感器可以充分了解工作量,因此已经进行了广泛的研究,以提供强大的生物标志物。在过去的几年里,机器学习技术已经被用来预测基于各种特征的认知工作量。凝视提取的特征,如瞳孔大小、眨眼活动和跳眼测量,已被用作预测指标。本研究的目的是使用凝视提取的特征作为认知工作量的唯一预测因子。研究了两个因素:时间压力和多任务处理。本研究结果表明,眼睛和凝视特征是认知工作量水平的有用指标,准确率高达88%。
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引用次数: 3
Exploring Artificial Intelligence methods for recognizing human activities in real time by exploiting inertial sensors 探索利用惯性传感器实时识别人类活动的人工智能方法
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635486
Dimitrios Boucharas, Christos Androutsos, N. Tachos, E. Tripoliti, Dimitrios Manousos, Vasileios Skaramagkas, Emmanouil Ktistakis, M. Tsiknakis, D. Fotiadis
The aim of this work is to present two different algorithmic pipelines for human activity recognition (HAR) in real time, exploiting inertial measurement unit (IMU) sensors. Various learning classifiers have been developed and tested across different datasets. The experimental results provide a comparative performance analysis based on accuracy and latency during fine-tuning, training and prediction. The overall accuracy of the proposed pipeline reaches 66 % in the publicly available dataset and 90% in the in-house one.
这项工作的目的是利用惯性测量单元(IMU)传感器,为实时人类活动识别(HAR)提供两种不同的算法管道。已经开发了各种学习分类器,并在不同的数据集上进行了测试。实验结果提供了在微调、训练和预测过程中基于准确性和延迟的性能对比分析。在公开可用的数据集中,拟议管道的总体精度达到66%,在内部数据集中达到90%。
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引用次数: 1
Effect of Continuous and Discrete Feedback on Agency and Frustration in a Brain-Computer Interface Virtual Reality Interaction 连续和离散反馈对脑机接口虚拟现实交互中的代理和挫折的影响
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635586
Thomas K. K. Kjeldsen, Thomas B. Nielsen, Hamzah Ziadeh, Steffen Lehmann, Louise D. Nielsen, Dávid Gulyás, B. I. Hougaard, H. Knoche, M. Jochumsen
Brain-computer interfaces (BCIs) provide users with a means to control external devices or applications using only voluntarily produced brain activity. Controlling a BCI through motor imagery is a skill that must be acquired, however, little evidence is available on how the user's agency and frustration are affected by different types of feedback during an interaction with a BCI. This was investigated during a virtual reality interaction where 14 naive participants controlled an avatar with a BCI while receiving either continuous or discrete feedback on their performance. The agency, frustration, ownership and BCI performance were assessed after each of the two conditions (continuous and discrete feedback). There was no statistical difference between the conditions although the participants generally rated agency higher for the continuous feedback which was also uncorrelated to the BCI performance. This suggests that continuous feedback can be useful for increasing agency for users with poor BCI performance by providing them with some knowledge of performance.
脑机接口(bci)为用户提供了一种仅使用自愿产生的大脑活动来控制外部设备或应用程序的方法。通过运动意象控制脑机接口是一项必须习得的技能,然而,很少有证据表明,在与脑机接口交互过程中,不同类型的反馈如何影响用户的能动性和挫折感。这是在虚拟现实互动中进行的调查,14名天真的参与者用脑机接口控制一个化身,同时接收关于他们表现的连续或离散反馈。在两种情况(连续反馈和离散反馈)后分别评估代理、挫败感、所有权和BCI绩效。两种情况之间没有统计学差异,尽管参与者通常对连续反馈的代理评级更高,这也与BCI表现无关。这表明,通过向BCI性能较差的用户提供一些性能知识,持续反馈可以帮助他们增加代理。
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引用次数: 2
Parallelization of lattice Boltzmann software for execution on multi-GPU clusters with application to the simulation of blood flow through human arteries 网格玻尔兹曼软件在多gpu集群上执行的并行化及其在人体动脉血流模拟中的应用
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635318
T. Djukić, N. Filipovic
It is important to consider the blood flow pattern when planning vascular interventions of atherosclerotic plaques. Large scale computer modeling can be very helpful in this case. The software presented in this paper numerically models blood flow through patient-specific blood vessels. Lattice Boltzmann method was used to simulate blood flow. The principles of GPU (Graphics Processing Unit) programming are applied during implementation and the developed software was parallelized using the CUDA (Compute Unified Device Architecture) and optimized to run on a multi-GPU cluster using the MPI approach. Using the multi-GPU infrastructure, numerical simulations can utilize larger amount of memory resources for the computation, making the level of reality of the models an order of magnitude higher. Execution of the presented software enables fast and reliable case-studies and parametric analyses useful for medical decision-making. The presented software can give medical professionals fast quantitative information about fluid flow in diseased arteries and assist them in selecting the most appropriate treatment.
在规划动脉粥样硬化斑块的血管干预时,考虑血流模式是很重要的。在这种情况下,大规模的计算机建模非常有帮助。该软件在本文中提出的数值模拟血液流动通过患者特定的血管。采用点阵玻尔兹曼方法模拟血流。在实现过程中应用了GPU(图形处理单元)编程原理,开发的软件使用CUDA(计算统一设备架构)并行化,并使用MPI方法优化以在多GPU集群上运行。利用多gpu架构,数值模拟可以利用更大的内存资源进行计算,使模型的真实程度提高了一个数量级。所提出的软件的执行使快速可靠的案例研究和参数分析对医疗决策有用。所介绍的软件可以为医疗专业人员提供有关病变动脉中流体流动的快速定量信息,并帮助他们选择最合适的治疗方法。
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引用次数: 0
Comparative Assessment of Computational vs. In Vitro Methods for the Estimation of Dry Powders for Inhalation Emitted Fraction 计算方法与体外方法对干粉吸入释放分数估算的比较评价
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635217
Jelisaveta Ignjatović, T. Šušteršič, S. Cvijić, Aleksandar Bodić, Jelena Duris, S. Ibrić, N. Filipovic
Emitted fraction (EF) is one of the critical quality attributes of dry powders for inhalation (DPIs). Traditionally, different in vitro methods have been used for the assessment of DPIs EF. However, the evolution in computer-based (in silico) methods led to the development of special fields, such as Computational Fluid Dynamics (CFD) coupled with fluid-particle dynamics models e.g., Discrete Phase Model (DPM) as a useful alternative for the assessment of DPIs aerodynamic performance. The aim of this study was to design a CFD-DPM model for the prediction of model DPIs EF, and assess the prediction power of this method by comparing the in silico prediction results with in vitro determined EF values, obtained by three different methods. The EFs of the solid lipid microparticles (SLM) DPIs were determined in vitro by Twin stage impinger, Next generation impactor and Fast Screening Impactor. CFD-DPM model was successfully designed, and then the simulation results indicated the percentage of particles that remained in the inhaler. Based on those data, DPI EFs were calculated to be in the range of 83 % and 92%, indicating that CFD-DPM simulations were able to catch the differences between five SLM DPI formulations. In addition, CFD-DPM predicted the regional particle deposition in the inhaler, which cannot be precisely determined based on in vitro experiments. CFD-DPM predicted EF values were generally comparable to the EF values obtained by three in vitro methods, although some differences were observed between in vitro and in silico values. Therefore, it can be concluded that although additional improvements of CFD-DPM designed model are still necessary in order to be able to precisely describe aerodynamic performance of SLM DPIs, CFD-DPM modeling can be considered as a very useful tool in DPIs development.
发射分数(EF)是吸入性干粉的关键质量属性之一。传统上,不同的体外方法已用于评估dpi EF。然而,基于计算机(计算机)方法的发展导致了特殊领域的发展,例如计算流体动力学(CFD)与流体-颗粒动力学模型(例如离散相模型(DPM))相结合,作为评估dpi气动性能的有用替代方法。本研究的目的是设计一种CFD-DPM模型来预测模型dpi的EF,并通过比较三种不同方法获得的计算机预测结果与体外测定的EF值来评估该方法的预测能力。采用双阶段冲击仪、下一代冲击仪和快速筛选冲击仪对固体脂质微颗粒(SLM) dpi进行体外EFs检测。成功地设计了CFD-DPM模型,仿真结果显示了吸入器中残留颗粒的百分比。基于这些数据,计算出的DPI EFs在83%和92%之间,这表明CFD-DPM模拟能够捕捉到5种SLM DPI配方之间的差异。此外,CFD-DPM预测吸入器内的区域颗粒沉积,这是体外实验无法精确确定的。CFD-DPM预测的EF值通常与三种体外方法获得的EF值相当,尽管在体外和计算机中观察到一些差异。因此,可以得出结论,虽然为了能够准确地描述SLM dpi的气动性能,还需要对CFD-DPM设计的模型进行额外的改进,但CFD-DPM建模可以被认为是dpi开发中非常有用的工具。
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引用次数: 0
In-silico Research Platform in the Cloud - Performance and Scalability Analysis 云中的芯片研究平台——性能和可扩展性分析
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635574
M. Ivanovic, A. Živić, N. Tachos, George Gois, N. Filipovic, D. Fotiadis
The paper describes experiences from building and cloudification of the in-silico research platform SilicoFCM, an innovative in-silico clinical trials' solution for the design and functional optimization of whole heart performance and monitoring effectiveness of pharmacological treatment, with the aim to reduce the animal studies and the human clinical trials. The primary aim of cloudification was to prove portability, improve scalability and reduce long-term infrastructure costs. The most computationally expensive part of the platform, the scientific workflow manager, was successfully ported to Amazon Web Services. We benchmarked the performance on three distinct research workflows, each of them having different resource requirements and execution time. The first benchmark was pure performance of running workflow sequentially. The aim of the second test was to stress-test the underlying infrastructure by submitting multiple workflows simultaneously. The benchmark results are promising, painting the infrastructure launching overhead almost negligible in this kind of heavy computational use-case.
本文介绍了硅芯片研究平台硅ofcm的构建和云化经验,硅ofcm是一种创新的硅芯片临床试验解决方案,用于全心脏性能的设计和功能优化以及药物治疗效果的监测,旨在减少动物研究和人体临床试验。云化的主要目标是证明可移植性、提高可伸缩性和降低长期基础设施成本。该平台中计算成本最高的部分,即科学工作流管理器,已成功移植到Amazon Web Services。我们在三个不同的研究工作流上对性能进行基准测试,每个工作流都有不同的资源需求和执行时间。第一个基准测试是连续运行工作流的纯粹性能。第二个测试的目的是通过同时提交多个工作流来对底层基础结构进行压力测试。基准测试结果很有希望,在这种计算量很大的用例中,基础设施的启动开销几乎可以忽略不计。
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引用次数: 1
A Natural Language Understanding Model COVID-19 based for chatbots 基于聊天机器人的自然语言理解模型COVID-19
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635248
Valmir Ferreira dos Santos Junior, João Araújo Castelo Branco, Marcos Antonio de Oliveira, T. C. D. Silva, L. A. Cruz, R. P. Magalhães
It is increasingly common to use chatbots as an interface to use services. Making this experience more humanized requires the chatbot to understand natural language and express itself using natural language. One crucial step to achieve this is to label the data with intentions and entities. After labeling, one can use the labeled data to train a Natural Language Understanding (NLU) component. The NLU component interprets the text extracting the intentions and entities present in that text. Manually label the data is an onerous and impracticable process due to the high volume of data. Thus, an unsupervised machine learning technique, such as data clustering, is usually used to find patterns in the data and thereby label them. For this task, it is essential to have an effective vector embedding representation of texts that depicts the semantic information and helps the machine understand the context, intent, and other nuances of the entire text. In this paper, we perform an extensive evaluation of different text embedding models for clustering, labeling, and training an NLU model using the text of attendances from the Coronavirus Platform Service of Ceará, Brazil. We also show how different text embeddings result in different clustering, thus capturing different intentions of patients.
使用聊天机器人作为使用服务的接口越来越普遍。让这种体验更加人性化,需要聊天机器人能够理解自然语言,并使用自然语言表达自己。实现这一目标的一个关键步骤是用意图和实体标记数据。标记后,可以使用标记的数据来训练自然语言理解(NLU)组件。NLU组件解释文本,提取文本中存在的意图和实体。由于数据量大,手动标记数据是一项繁重且不切实际的过程。因此,一种无监督的机器学习技术,如数据聚类,通常用于发现数据中的模式,从而标记它们。对于这项任务,必须有一个有效的文本向量嵌入表示来描述语义信息,并帮助机器理解整个文本的上下文、意图和其他细微差别。在本文中,我们对不同的文本嵌入模型进行了广泛的评估,用于聚类、标记和训练NLU模型,使用来自巴西塞雷冠状病毒平台服务的出席文本。我们还展示了不同的文本嵌入如何导致不同的聚类,从而捕获不同的患者意图。
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引用次数: 3
Numerical simulation of fractional flow reserve in atherosclerotic coronary arteries 冠状动脉粥样硬化部分血流储备的数值模拟
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635457
I. Šaveljić, T. Djukić, D. Nikolić, S. Djorovic, N. Filipovic
Cardiovascular diseases are the leading cause of death in the world with an incidence of about 30% of total mortality. It is a disease of the blood vessels of the heart that most often occurs due to the process of atherosclerosis. The process of atherosclerosis leads to narrowing of the coronary arteries, and thus to a reduced supply of blood or oxygen to the heart muscle. A fractional flow reserve (FFR) indicates the severity of blood flow blockages in the coronary arteries and allows physicians to identify which specific lesion or lesions are responsible for patient ischemia. In this paper, we studied the values of the FFR, using numerical simulations, on the geometries obtained by reconstructing the angiogram images.
心血管疾病是世界上死亡的主要原因,发病率约占总死亡率的30%。它是一种心脏血管疾病,最常因动脉粥样硬化过程而发生。动脉粥样硬化的过程导致冠状动脉狭窄,从而减少心肌的血液或氧气供应。分数血流储备(FFR)表明冠状动脉血流阻塞的严重程度,使医生能够确定哪些特定病变或病变导致患者缺血。在本文中,我们通过数值模拟研究了重建血管造影图像得到的几何图形的FFR值。
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引用次数: 0
Adaptive Semi-automatic Robot Control by Tongue in a Remote Setting for Individuals with Tetraplegia 四肢瘫痪患者远程自适应半自动机器人舌头控制
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635539
Anton Bjømdahl Mortensen, Emil Tribler Pedersen, J. Knudsen, J. Mortensen, Marie Hiorth Bogestrand, L. Struijk, Ásgerdur Arna Pálsdóttir
Individuals with tetraplegia are severely limited in terms of independence, which can lead to depression and premature death. The field of robotics has sought to create solutions for increased independence by enabling individuals with tetraplegia to perform physical activities. This includes semiautomatic solutions. The use case of an assistive robotic manipulator (ARM) and thus increased independence could be expanded by allowing remote control, e.g. when the user is lying in bed. This study presents and evaluates semi-autonomous intraoral tongue-based control of a seven degree of freedom ARM/gripper in a near and remote setting. The system consists of a tongue control interface (iTongue), a semi-automatic framework based on YOLOv5 and adaptive levels of automation, an Intel Realsense D435i camera and a JACO robotic manipulator. Two study participants completed ten rounds of controlling the JACO ARM to reach and pick up a soda bottle and pour from it in a cup. The semi-automation improved the grasping performance for both of the study participants, particularly when controlling in a remote setting, decreasing the cognitive load and the overall task completion time. The presented system has the potential to increase the independence and quality of life for individuals with tetraplegia, by enabling the user to perform physical activities even when lying in bed. Future work should include expanding the semi-automation to other activities of daily living and evaluating the system in a greater population and by individuals with tetraplegia.
四肢瘫痪患者在独立性方面受到严重限制,这可能导致抑郁和过早死亡。机器人领域一直在寻求创造解决方案,使四肢瘫痪的人能够进行身体活动,从而提高独立性。这包括半自动解决方案。辅助机器人操纵器(ARM)的使用案例可以通过允许远程控制来扩展,从而增加独立性,例如当用户躺在床上时。本研究提出并评估了在近距离和远程设置中基于舌内半自主控制的七自由度ARM/夹具。该系统由舌控接口(ittongue)、基于YOLOv5和自适应自动化水平的半自动框架、英特尔Realsense D435i摄像头和JACO机器人机械手组成。两名研究参与者完成了十轮控制JACO ARM来拿起一个苏打水瓶,然后把它倒进杯子里。半自动化提高了两名研究参与者的抓取表现,特别是在远程控制时,减少了认知负荷和整体任务完成时间。该系统有可能提高四肢瘫痪患者的独立性和生活质量,使用户即使躺在床上也能进行身体活动。未来的工作应该包括将半自动化扩展到日常生活的其他活动中,并在更大的人群和四肢瘫痪患者中评估该系统。
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引用次数: 0
Bioelectrical Circuit from Charged Proteins as Biomarker of Renal Damage 来自带电蛋白的生物电回路作为肾脏损伤的生物标志物
Pub Date : 2021-10-25 DOI: 10.1109/BIBE52308.2021.9635407
H. Nieto-Chaupis
At first phases of renal damage, kidney would allow to pass giant proteins such as albumin whose size is of order of nm., surpassing the glomerular zone and therefore going to the Bowman's space. In this manner at the glomerular area proteins can form charge density that would give origin to spontaneous currents. In this paper equations corresponding to the Kirchhoff equation are derived. The usage of classical electrodynamics and the diffusion equation allows to derive the voltage as function of permittivity. This can be seen as an efficient biomarker. Therefore advanced technologies with capabilities for measuring micro and nano voltages in prospective implanted devices might to play a crucial role to anticipate the renal damage.
在肾脏损害的初期,肾脏允许通过巨大的蛋白质,如白蛋白,其大小约为nm。,超过肾小球区,因此进入鲍曼空间。通过这种方式,肾小球区域的蛋白质可以形成电荷密度,从而产生自发电流。本文导出了与基尔霍夫方程相对应的方程。利用经典电动力学和扩散方程可以推导出电压作为介电常数的函数。这可以看作是一种有效的生物标志物。因此,具有测量微纳电压能力的先进技术可能在预测肾损害方面发挥关键作用。
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引用次数: 0
期刊
2021 IEEE 21st International Conference on Bioinformatics and Bioengineering (BIBE)
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